38 results about "Tangeretin" patented technology

The invention relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising an extract from the Ortanique peel. The invention also relates to compositions and methods for treating hypercholesterolemia, including methods for increasing HDL cholesterol levels, using a composition comprising substantially similar amounts of tetramethylscutellarein and nobiletin by weight and/or a composition comprising substantially similar amounts of tetramethylscutellarein, nobiletin, and tangeretin by weight.

The polymethoxyl flavone injection includes polymethoxyl flavone, alcohol and surfactant, and the polymethoxyl flavone is mixture of two or more of nobiletin, tangeretin, sinensetin, heptamethoxyl flavone and isotangeretin. The present invention solves the solubility and stability problem of polymethoxyl flavone injection, and the polymethoxyl flavone injection has high safety, coincides with medicine standard and suitable for intramuscular injection and intravenous injection. The present invention also discloses the preparation process of the polymethoxyl flavone injection.

The present invention provides a composition containing tangeretin as an active ingredient for external application to the skin. The present invention also provides a composition containing tangeretin and EGCG for external application to the skin. The present invention also provides a composition for external application to the skin, comprising, as an active ingredient, mandarin peel extracts containing tangeretin. The present invention also provides a composition for external application to the skin comprising mandarin peel extracts containing tangeretin and further comprising green tea extracts containing Epigallocatechin gallate (EGCG). The composition has excellent antioxidative effects, and therefore can be applied as a cosmetic composition, a pharmaceutical composition or a health food composition. Furthermore, the composition may have superior effects of preventing skin erythema, improving skin tone and preventing skin aging.

The invention relates to a Rutaceae citrus reel extractive, which uses the reel of Rutaceae citrus plant as material, wherein the contents of nobiletin and tangeretin are 30-80%. The invention also provides a method for using said extractive to prepare cosmetics, which has constant sun-screening effect in UVA and UVB areas, to avoid ultraviolet light to hurt skin.

The invention discloses a method for extracting and purifying tangerine polymethoxyflavone, which belongs to the technical field of extracting and purifying the effective components of farm and sideline products. The method comprises the following processing steps: (1) extracting the tangerine polymethoxyflavone, (2) carrying out column chromatography purification on the crude extract of the tangerine polymethoxyflavone and the like. Nobiletin and tangeretin in the crude extract of the tangerine polymethoxyflavone can respectively reach 30.8 percent and 22.7 percent in content; the purification effect of selected macroporous resin on the crude extract is higher; the total content of the macroporous resin can reach 74.1-82.1 percent; and the total recovery rate can reach 45.9-68.6 percent. Moreover, the method for extracting and purifying the tangerine polymethoxyflavone has the characteristics that equipment is simple, the process is reasonable and is easy to implement, the cost is low, and a product can meet the requirements of food, health care products and the like. The method can be popularized and applied to tangerine producing areas and biochemical enterprises.

The invention discloses a natural compound feed additive for removing veterinary drug residues. The natural compound feed additive is prepared from the following components in parts by weight: 1 part of procyanidine, 1 part of astaxanthin, 1 part of resveratrol, 1 part of curcumin, 1 part of allicin, 1 part of porphyra polysaccharide, 1 part of porphyra polyphenol, 1 part of phycobiliprotein, 1 part of tea polyphenol, 1 part of quercetin, 1 part of chitosan and 1 part of tangeretin; and the ratio of the feed additive to the feed is (1:100) to (1:500) in use. According to the method, the residues of tilmicosin, florfenicol, ceftiofur sodium, thiabendazole, enrofloxacin, gentamicin sulfate, oxytetracycline, sulfadimethoxine and halofuginone hydrobromide in livestock or poultry bodies can be effectively reduced; the natural compound feed additive has the characteristics of being free of pollution and free of public hazard, and can be applied to removal of veterinary drug residues from food animals of which the veterinary drug residues exceed the standard due the factors such as veterinary drug application and environmental pollution, so as to ensure the hygiene and safety of animal food.

The invention relates to a skin external composition containing tangeretin and EGCG. Moreover, the invention provides a skin external composition using orange peel extract containing tangeretin and green tee extract containing EGCG, which does not stimulate skin and has skin whitenning effect with saftey.

The invention provides a method for separating and purifying seven flavonoid compounds from a tangerine oil vacuole layer. According to the method provided by the invention, three steps, which are solvent extraction, Sephadex gel filtration and high-speed countercurrent chromatography (HSCCC) purification are adopted, a tangerine fruit oil vacuole layer is used as a raw material, seven flavonoid compounds can be obtained finally by virtue of purification, and the purities of the seven flavonoid compounds are over 97 percent. The method is simple in operation, short in production cycle, small in sample dosage and little in equipment investment, the condition is stable and easily controlled, and the seven flavonoid compounds comprise naringin, hesperidin, neohesperidin, sinensetin, nobiletin, tangeretin and 5-demethylnobiletin. The method is applicable to industrial production and scientific study.

The invention discloses application of tangeretin serving as sensitizer used for preparing chemotherapeutics used for curing a solid tumor. An in vitro cell experiment shows that when concentration of 5-fluorouracil is 25ug\ml and 50ug\ml, tangeretin drug combination can strengthen antineoplastic activity of the 5-fluorouracil, and synergistic effects are shown to restrain growth of a human colon cancer cell HCT-116. When the concentration of the 5-fluorouracil is 25ug\ml, effects of 5-fluorouracil drug combination are the best. An animal experiment shows that drug combination of the tangeretin and the 5-fluorouracil has obvious inbibitional effects on growth of a mice transplant tumor S180 sarcoma, and a mice death rate caused by larger toxicity of chemotherapeutics 5-fluorouracil is reduced largely. The drug combination of the tangeretin and the 5-fluorouracil reduces a dosage of the 5-fluorouracil, so a side effect of mice reduced weight caused by the chemotherapeutics 5-fluorouracil can be relieved, and toxicity of the 5-fluorouracil to a mice is reduced.

The invention belongs to the field of food/health product preparation, and particularly relates to citrus flavonoid protein powder abd a preparation method and application thereof. The citrus flavonoid active protein powder is characterized in that the preparation method of the citrus flavonoid active protein powder comprises the following steps of: (1) adding hesperetin into citrus seed oil according to a concentration ratio of 10 to 30mg/g to obtain an oil phase; dissolving concentrated whey protein and a composite wall material into water to obtain a water phase; (2) mixing the oil phase and the water phase to obtain an emulsion; and (3) drying the emulsion to obtain the citrus flavonoid active protein powder, wherein the composite wall material comprises maltodextrin and sodium caseinate, and the weight ratio of the maltodextrin to the sodium caseinate is (1 to 2): 5. The citrus flavonoid active protein powder solves the problem of low bioavailability caused by poor solubility of citrus flavonoid, and the concentrated whey protein is added into the product, so that the citrus flavonoid active protein powder is a good nutritional health product, and the application field of the hesperetin in an aqueous solution is expanded.

The invention discloses an application of hesperetin, tangeretin and glycyrrhetinic acid in inhibiting chloride ion channels, wherein the chloride ion channels can be inhibited; the invention discloses the application in development of drugs for treatment of diarrhea, heart disease, lung disease, stomach disease, brain disease, mental disease, rhinitis, otology diseases and ocular diseases. The detection verification method has raw materials easy to obtain, and the detection method is simple.

The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is tangeretin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

The invention provides an application of tangeretin in preparing an oxidative stress protection product. The ability of tangeretin to withstand hydrogen peroxide oxidative stress damage in human liverL02 cells, human gastric GES cells, human umbilical vein endothelial cells (HUVEC), and human fibroblast WI-38 cells is significantly increased, and the cells maintain the ability to withstand the oxidative stress damage after the tangeretin is removed; and the tangeretin can be used as a functional food, a health care product or a preventive drug for the prevention and treatment of diseases related to oxidative stress damage.

The invention relates to a pharmaceutical composition for hair growth and a preparation method thereof. Its active ingredients are composed of the following raw materials: safflower, rehmannia glutinosa, rehmannia glutinosa, Sophora flavescens, Radix Paeoniae Alba, Sperancifolia, Polygonatum, Cortex Phellodendri, Codonopsis pilosula, Minoxidil, Tangeretin, Epidermal Growth Factor. The present invention uses safflower, rehmannia glutinosa, rehmannia glutinosa, flavescens flavescens, Radix Paeoniae Alba, Tugucao, Polygonatum, Cortex Phellodendri and Codonopsis pilosula as components of traditional Chinese medicines, and takes minoxidil, orange peel and epidermal growth factor as components of western medicines. Used in combination, it can penetrate the cortex and be directly absorbed by cortical cells, improve the nutritional status of the hair, regulate the balance of endocrine and sex hormones, stimulate the production of melanin in the human body, prevent and treat both physiological and pathological hair loss, and have good clinical effects.

The invention belongs to the field of medicines, medical foods, health-care foods, functional foods or foods, discloses new application of tangeretin, and particularly relates to application of the tangeretin in preparation of medicines, health-care products, functional foods, medical foods or foods for regulating cortisol levels of a human body, especially, the situations of regulating cortisol increase in a motion state and regulating and controlling excessive secretion of the cortisol in the human body. Researches show that the tangeretin has an obvious effect of regulating the cortisol level in the motion state, inhibits excessive secretion of the cortisol, reduces oxidative stress reaction of an organism caused by high-intensity motion, increases the concentration ratio of testosterone to cortisol in serum of the organism, promotes muscle synthesis and improves the fatigue state after motion.

An extract of Citrus depressa, preferably a water and/or organic solvent extract of a fruit of leaf of Citrus depressa, a supercritical extract of a fruit of leaf of Citrus depressa, or a subcritical extract of a fruit of leaf of Citrus depressa, which comprise 0.3 mass % or more of a polymethoxyflavonoid more than in terms of solid matter, for example, an extract of Citrus depressa comprising 0.2 mass % or more of nobiletin and/or 0.1 mass % or more of tangeretin in terms of solid matter, or a polymethoxyflavonoid such as nobiletin or tangeretin is used as an active ingredient of an IGF-1 production-promoting agent.

The invention discloses cold-proof and cold-resistant feed for newborn calves in a wintering period and a preparation method thereof. The cold-proof and cold-resistant feed is prepared from, by weight, 500-600 parts of double-low rapeseed meal, 10-18 parts of sodium carbonate, 70-80 parts of bean dregs, 40-50 parts of corn chop, 1-2 parts of pepper seed powder, 2-3 parts of star aniseed powder, 2-3 parts of salt, 50-60 parts of potato powder, 3-4 parts of giant knotweed powder, 0.4-0.5 part of corydalis tuber extract, 0.4-0.5 part of cassia twig extract, 0.3-0.4 part of tangeretin, 14-16 parts of pumpkin starch, 3-4 part of licorice powder, 2-3 parts of Chinese thorowax root powder, 32-35 parts of black bean flour, 0.2-0.3 part of EM bacteria, 8-10 parts of dried animal blood and 3-4 parts of ginger juice. The feed can promote nutrient digestion and utilization of the newborn calves, promote metabolism, accelerate blood circulation and improve the cold-proof and cold-resistant ability.

The invention belongs to the field of medicines, and particularly relates to a composition with anti-aging activity, a preparation of the composition and application of the composition in resisting aging and aging-related symptoms. Specifically, the composition disclosed by the invention is mainly composed of a GPX4 agonist and a 15-LOX inhibitor, and vitamin E is supplemented to achieve a synergistic effect. Wherein the GPX4 agonist is prepared from one or more of 6-gingerol, 8-gingerol and 10-gingerol; the 15-LOX inhibitor is prepared from one or more of quercetin, baicalein, eugenol, nobiletin, sweet orange flavone and tangeretin. The composition and the preparation thereof can relieve age-related natural skin aging and accelerated skin aging caused by external adverse factors; meanwhile, the traditional Chinese medicine composition has a certain curative effect on body aging-related symptoms such as cognitive memory decline and immune function decline, and has no obvious side effect.