83 results about "Im injections" patented technology

The invention relates to a method for stimulating an immune response by intramuscular injection of an artificial nucleic acid molecule comprising an open reading frame encoding an antigen and a 3′-UTR comprising at least two poly(A) sequences. The method may yield an increased immune response to the antigen or an increased neutralizing antibody response to the antigen.

The invention discloses mannheimia haemolytica outer membrane vesicles as well as a preparation method and application thereof, and belongs to the technical field of bioengineering. The OMV is separated from Mh-5 strain culture supernatant through tangential flow ultrafiltration combined with an ultracentrifugation technology, and animal experiments prove that a high-level IgG / IgM antibody can be induced by intramuscular injection of 50 micrograms per mouse, expression of inflammatory factors such as IL-6 and TNF-alpha of the spleen is remarkably improved, the protection rate after challenge reaches 85.7%, and pathological damage is remarkably lighter than that of an inactivated vaccine group. According to the scheme provided by the invention, the problems of insufficient serotype coverage and antibiotic resistance in the prior art are solved, and a new strategy is provided for prevention and control of mannheimia haemolytica.

The invention relates to a method of treating or preventing a disease or condition comprising administering a therapeutically effective amount of a psychedelic compound to a patient by intramuscular injection. Uses, formulations and kits are also described.

The invention relates to the technical field of animal husbandry, in particular to a synchronous oestrus-timing insemination method suitable for cattle, which comprises the following steps: firstly, performing intramuscular injection of PG (cloprostenol sodium) at different time points after calving to promote uterine recovery and luteolysis and lay a synchronous oestrus foundation; the method comprises the key steps that GnRH (gonadotropin release hormone) is given through intramuscular injection on the 43rd day, the 53rd day, the 60th day and the 69th day, pituitary is promoted to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), collection and screening of follicles are guided, follicle maturation is promoted, the oestrus uncovering rate and the oestrus conception rate are increased, a melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day, and the melatonin implant is implanted in a subcutaneous implantation mode on the 63rd day. The synthesis of ovarian hormones is promoted by regulating the hypothalamus-pituitary-gonad axis, the secretion of follicle cell factors and maturation promoting factors is promoted, the development of granular cells is promoted, and the maturation of oocytes is promoted. According to the method, the pregnancy rate of a double-synchronization-timing insemination scheme which is most widely used in a large-scale dairy cow breeding pasture at present can be remarkably increased, and feasible technical support is provided for success of increasing the breeding efficiency of cows.

Compounds and pharmaceutical formulations including a compound and an oil, which may be formulated for intermediate- or long-acting intramuscular injection. Methods for treating respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), coronavirus, SARS CoV-2, and other RNA virus infections in mammals.

This invention provides a modified BoNT / A for treating facial wrinkles, wherein the modified BoNT / A is administered via intramuscular injection at multiple sites on an individual's face, wherein the modified BoNT / A is administered at a unit dose of greater than 1754 pg or greater than 8000 pg per site, wherein the multiple sites are selected from: up to two sites on the corrugator supercilii muscle and one site on the depressor supercilii muscle for treating glabellar lines; up to five sites on the frontalis muscle for treating forehead wrinkles; and up to three sites on the orbicularis oculi muscle for treating lateral canthal wrinkles, wherein the total dose of modified BoNT / A administered during treatment is up to 264,000 pg (and optionally greater than 88,000 pg), and wherein the modified BoNT / A comprises a BoNT / A light chain and a translocation domain (H N The structure domain), and the BoNT / B receptor binding domain (H C (structural domain).

The present invention relates to aqueous saline solutions comprising dantrolene and optionally at least one additional active ingredient, such as botulinum neurotoxin, and their use for various therapeutic and / or aesthetic purposes. The solutions can be administered in any suitable manner, but have the advantage of being particularly well-suited for intramuscular injection.

Compounds comprising antiviral prodrugs, and pharmaceutical formulations comprising the compounds, which can be orally bioavailable or formulated for intramuscular injection. Methods for making compounds such as antiviral prodrugs. Methods for treating coronavirus and other RNA viral infections in mammals. Methods for producing pharmaceutical triphosphates.

The utility model belongs to the field of medical instruments, and particularly relates to a fulvestrant intramuscular injection positioning ruler which comprises a long fixed ruler, two short shifting rulers and two arc-shaped pieces, and the two short shifting rulers are located on the two sides of the long fixed ruler respectively and rotationally connected with the long fixed ruler; the two arc-shaped pieces are symmetrically distributed on the two sides of the long fixed ruler, one side of each arc-shaped piece is fixedly connected with the long fixed ruler, the other side of each arc-shaped piece is fixedly connected with the short shifting ruler, an arc-shaped notch is formed in the inner side of each arc-shaped piece, and a plurality of positioning holes are formed in each arc-shaped piece. The fulvestrant injection device is directly aligned with the highest point of iliac spine and the peak of hip fissure of a human body through the positioning rule in one step, compared with operation modes such as a cross method and a line connection method, the time for manual searching and positioning is saved, meanwhile, injection of fulvestrant is completed in the positioning hole, and the injection efficiency is improved. And injection errors and complications caused by non-professional operation methods, inaccurate manual positioning, repeated part injection and the like are solved, so that the injection pain of a patient is reduced, and the treatment compliance and the life quality are improved.

An embodiment of the present invention provides a biocompatible, thermosensitive hydrogel composition for subcutaneous or intramuscular injection, the hydrogel comprising a poloxamer, such as poloxamer 338, poloxamer 188, or poloxamer 407, or a mixture thereof, and the composition includes a therapeutic protein or antigen embedded in the composition for sustained release.

The present invention relates to aqueous compositions comprising dantrolene and optionally also at least one additional active principle, such as botulinum neurotoxin, and their use for various therapeutic and / or aesthetic / cosmetic purposes. The compositions can be administered in any suitable way but are advantageous in that they are particularly well adapted to intramuscular injection, subcutaneous injection and / or intradermal injection.

The invention discloses a dexketoprofen trometamol nasal spray and a preparation method thereof, a buffering agent is used as a stabilizer, and the dexketoprofen trometamol nasal spray which is good in stability, small in irritation, convenient, rapid in effect taking and extremely small in side effect is provided, so that the medication compliance of patients and the convenience of clinical medication are improved; after being administrated, the nasal spray can be quickly absorbed through nasal mucosa, the absorption speed is equivalent to that of intramuscular injection, the nasal spray can quickly reach the peak concentration as intramuscular injection, and the curative effect can be quickly exerted; the preparation has the advantages of no first-pass effect during nasal mucosa administration, high bioavailability and rapid absorption, is suitable for self-rapid analgesia, and is stable in process and suitable for large-scale production.

The present application relates to a kind of cat rhinotracheitis, feline calicivirus disease, cat pancytopenia triple subunit vaccine, preparation method and its application.The present application is expressed antigen protein using CHO cell strain, and synergistic effect is combined molecular adjuvant (IL-2, GM-CSF, CpG) with MF59 nanoemulsion, molecular adjuvant composition is adsorbed on the surface of MF59 nanoemulsion, then embedded in polylactic acid-glycolic acid copolymer microsphere, mixed with triple subunit protein to form vaccine preparation.The vaccine prepared in the present application can stimulate humoral immunity and cellular immunity simultaneously by subcutaneous or intramuscular injection, significantly improve antibody titer and attack protection rate, prolong immune protection period, and reduce injection site adverse reactions.The synergistic effect of protein and molecular adjuvant and MF59 makes the vaccine superior to traditional subunit vaccine in safety, stability and immunological efficacy, and is suitable for high-efficiency prevention of three viral infectious diseases in feline.

The invention relates to the technical field of mRNA vaccine research and development, and discloses a Tp0136T cell epitope mRNA vaccine based on lipid nanoparticle delivery and application of the Tp0136T cell epitope mRNA vaccine in syphilis prevention, the vaccine contains an mRNA sequence and an LNP delivery system, the mRNA sequence contains a Tp0136T1T cell epitope coding region (amino acid L477-S486, optimized by codon), a Cap 1 structure, optimized UTR and poly (A) tails of 65-76 adenosine, and psi or m5C is used for replacing trona; the LNP is prepared from SM-102, DSPC (Distearoyl Pyrrolidone), cholesterol and DMG-PEG (Dimethyl Glycol-Polyethylene Glycol) according to a molar ratio of 50 The particle size of the vaccine is less than or equal to 150nm, PDIlt; 0.2, the Zeta potential is-5 to-15 mV, and the encapsulation efficiency is greater than or equal to 93.47%. The preparation method comprises the steps of mRNA design synthesis, mRNA-LNP preparation characterization and in-vitro expression verification, through intramuscular injection inoculation, strong Th1 type and CD8 + CTL immune response can be induced, treponema pallidum load and skin ulcer rate can be reduced, and the method can be used for syphilis prevention.

The application provides a kind of medicine composition for treating muscle and bone disease and its application, belong to medical technology field.The medicine composition includes the following weight parts components: compound angelica injection 5-10 parts, kadsura injection 5-10 parts, wild medlar injection 5-10 parts, methylcobalamin injection 5-10 parts;It can also be selectively added vitamin B1 injection, vitamin B12 injection, yellow Chinese wax injection or bone peptide injection.The composition of the application is administered by acupoint injection or intramuscular injection, utilizes the synergistic effect of multiple traditional Chinese medicine injection and western medicine injection, reaches the comprehensive treatment effect of promoting blood circulation to remove blood stasis, dispelling wind to stop pain, nerve nutrition.Clinical experiments show that the application has significant effect on lumbar disc herniation, cervical spondylosis, shoulder periarthritis, knee osteoarthritis, femoral head necrosis, osteoporosis and the like, and the total effective rate is more than 95%, with fast effect, low recurrence rate, and no hormone-related side effects, suitable for patients of all ages.

The invention discloses nucleotide of fusion protein for coding neutrophil elastase and application of the nucleotide. A nucleotide sequence for coding the fusion protein is as shown in SEQ ID NO. 8; the nucleotide sequence of mRNA (messenger ribonucleic acid) for coding the fusion protein is as shown in SEQ ID NO. 12; the fusion protein comprises an optimized human neutrophil elastase (ELANE) fragment and an optimized human alpha2-macroglobulin (A2M) fragment. The mRNA preparation which is encapsulated by the nano-lipid particles and is used for coding the wild type ELANE can achieve a tumor elimination effect only by complex intratumor injection. According to the mRNA preparation which is encapsulated by the nano-lipid particles and is used for coding the ELANE fusion protein, tumor elimination in a mouse body can be realized only through intramuscular injection administration, the operation is simpler and more convenient, and the mRNA preparation is beneficial to treatment of scattered and tiny tumor focuses in the body.

Briefly, an injection delivery system is described for subcutaneous or intramuscular injection of a drug, in particular a large volume of a biologic drug, high and low viscosity biologies, or a large volume of a high viscosity and low viscosity chemical drug. The injections may be self-administered or performed by a caregiver. The system uses a pump to move a drug from a vial, thorough an infusion set, and into the patient. A vial of a biological or chemical drug is set into a vial adapter that is associated with the pump, which can be manual or powered. A fluidics subassembly connects the vial adapter, pump, and the infusion set so that a drug pathway is enabled from the vial to the patient. The fluidics subassembly has one or more check valves to assure that the drug pathway is only enabled for a one-way drug flow out of the vial and to the patient. The infusion set has flexible tubing that connects the fluidics subassembly to cannula assembly inside an infuser housing. The cannula assembly has an air evacuation assembly near the tip of the needle. This air evacuation assembly is constructed to safely exhaust air from the cannula assembly at three times: (1) at initial setup to exhaust air while the drug is filling the cannula assembly, which enables the self-priming; (2) during injection to exhaust drug-entrapped air, which increases injection safety; and (3) at the end of drug delivery to exhaust air after the full dose of drug has been delivered to the cannula assembly, including drug that was in the tubing, which reduces wasted drug and minimizes the amount of drug overfill required in the vial.

The utility model relates to the technical field of injectors, in particular to a clinical intramuscular injection universal injector which comprises an injection sleeve, a needle head arranged at one end of the injection sleeve, a piston connected to the injection sleeve in a sliding mode, a push rod with one end extending into the injection sleeve to be connected with the piston and a push head arranged at the end of the push rod. The fixed sleeve is fixed to the injection sleeve, the movable sleeve is detachably connected to the fixed sleeve, one end of each support is connected with the movable sleeve, the three supports are arranged in a triangular shape, and when two thirds of the needle head is inserted into the human body, the bottom ends of the three supports abut against the skin of the human body; according to the intramuscular injection needle, the insertion depth of the needle head can be guaranteed, the needle head can be effectively prevented from being continuously immersed into the skin in the propelling injection process, the situation that the injection position is inclined is avoided, the difficulty of clinical intramuscular injection is reduced, and the intramuscular injection effect is guaranteed.

The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

The invention relates to a long-acting sustained-release pharmaceutical preparation and a preparation method thereof, the long-acting sustained-release pharmaceutical preparation is a microsphere preparation, the microsphere comprises brexpiprazole and PLGA, the content of the brexpiprazole is 45%-75% of the total weight of the microsphere, and the content of the PLGA is 55%-25% of the total weight of the microsphere; the viscosity of the PLGA is 0.15 to 0.25 dl / g, and the molecular weight of the PLGA is 8000 to 32000. The microsphere is high in drug loading capacity, the administration dosage can be effectively reduced, subcutaneous or muscle administration pain of a patient is reduced, the prepared sustained-release microsphere has no burst release phenomenon, and the change of the blood concentration in an effective release period in a rat is stable.

The invention relates to an automatic subcutaneous insulin injection device for the endocrinology department. The automatic subcutaneous insulin injection device comprises a rack, an arm fixing module, an automatic injection module, a driving module and a main control module. The arm fixing module is provided with an adjustable supporting seat and a fixing belt and is used for being matched with arms of different patients. The automatic injection module adopts a pneumatic design, and a negative pressure hole in a needle can adsorb skin to form wrinkles, so that intramuscular injection is avoided; the first pneumatic telescopic piece drives the needle cylinder to pierce subcutaneously, and the second pneumatic telescopic piece pushes the piston to complete injection. The driving module controls overall lifting, and the main control module coordinates all actions. The device realizes automation and standardization of arm insulin injection, is safe and efficient to operate, and is suitable for a clinical environment.

The utility model relates to an efficient poultry vaccine intramuscular injection device which comprises an obliquely-arranged stepping support and a PLC, an injection device and a propelling device are arranged on the front end face of the stepping support, one end of the injection device is connected with the propelling device, a neck fixing device is arranged at one end of the stepping support, and the other end of the stepping support is connected with the PLC. The neck fixing device comprises a first connecting piece, a second connecting piece and a neck fixing frame arranged on the first connecting piece, the second connecting piece is connected with the stepping support, the bottom end of the second connecting piece is hinged to the first connecting piece, a proximity switch is arranged on the second connecting piece, and the neck fixing frame is connected with the neck fixing frame in a non-external force state. One side of the top end face of the hinged first connecting piece is attached to the inner wall of the second connecting piece, the proximity switch is far away from the side edge of the first connecting piece, the side edge of the first connecting piece abuts against the proximity switch in the state that the first connecting piece is lifted upwards under external force, and through the arrangement of the proximity switch, the advantages of being high in injection efficiency and low in cost are achieved.

The injection filtering device comprises an ampoule bottle medicine mixing cup, the open end of the ampoule bottle medicine mixing cup is an ampoule bottle inserting end, and the other end of the ampoule bottle medicine mixing cup is an empty needle nipple connecting end connected with an empty needle nipple of an injector in a matched mode. A filter membrane is arranged on the cross section of the inner wall of the ampoule bottle medicine mixing cup and located between the ampoule bottle inserting end and the empty needle nipple connecting end. The filter membrane is arranged on the cross section of the inner wall of the medicine mixing cup of the ampoule bottle, the empty needle nipple connecting end of the medicine mixing cup of the ampoule bottle is connected with the empty needle nipple on the injector, the broken ampoule bottle is inserted into the inserting end of the medicine mixing cup of the ampoule bottle, and when the injector extracts medicine liquid in the ampoule bottle through the medicine mixing cup of the ampoule bottle, the medicine liquid in the ampoule bottle can be extracted through the medicine mixing cup of the ampoule bottle. According to the ampoule bottle medicine mixing cup, the filtering film can completely intercept glass chips generated when the bottle neck of the ampoule bottle is broken off in the ampoule bottle medicine mixing cup, the glass chips are prevented from entering a syringe, and after intramuscular injection is conducted, the glass chips generated when the bottle neck of the ampoule bottle is broken off are effectively prevented from entering subcutaneous tissue.

The invention provides a nano vaccine vector based on cholesteroid-free capsule protein and application of the nano vaccine vector, and belongs to the technical field of nano particle vaccines. The nano vaccine carrier is formed by sequentially connecting cholesteroid-free capsule protein, extension peptide, linker and molecular glue from an N end to a C end. The invention also provides a nano vaccine based on the cholesteric plasma-free capsule protein. The antigen is obtained by reacting the carrier with an antigen connected with SpyTag, SpyTag002 or SpyTag003. The invention also provides a mycoplasma hyopneumoniae nano vaccine and a new crown nano vaccine. The antigen is obtained by reacting the carrier with an antigen connected with SpyTag003. The nano vaccine vector disclosed by the invention can be used for intramuscular injection vaccines and mucosal vaccines for human and livestock, can remarkably improve the immune effect and enhance the immune response while displaying antigens, has a remarkable self-adjuvant effect, and provides a safe and efficient potential choice for the development of subunit vaccines.

Self-administered pharmaceutical compositions of epinephrine and its prodrugs are described as having pharmacokinetic parameters that are comparable to those compositions administered by a health care professional and by intramuscular injection.

Embodiments relate to an autoinjector for automatic subcutaneous or intramuscular injection of a drug, and provide an ergonomic structure for grip stability, rolling prevention, visibility, and pain relief when a user presses the autoinjector against the skin to operate same. The autoinjector according to embodiments comprises a housing which forms the exterior, wherein the housing includes a support part and a grip part that have different maximum outer widths in a cross section perpendicular to a central axis thereof, the grip part extends in the axial direction on a distal side of the support part, and the maximum outer width of the grip part is smaller than the maximum outer width of the support part, thus preventing slipping. In addition, the cross section of the grip part has a non-circular quadrilateral contour, thereby preventing rolling, the housing includes a proximal part and a distal part that have different transparencies, thereby providing visibility and psychological stability, and an activation member that comes into contact with the skin includes, in a proximal end surface thereof, a protruding shape for increasing local pressure, thereby relieving injection pain.

The present invention relates to an apparatus for administering fluids intramuscularly containing a syringe with an injectable fluid and comprising a casing (1), protection means for protecting the needle (2) of the syringe, a spring (6) and displacement means for displacing the skin in a direction substantially perpendicular to the path of penetration of the needle (2). The apparatus improves procedural efficiency regardless of the user's dexterity, prevents the inoculated fluid from leaking from the injection site, and reduces or eliminates pain and the risk caused by accidental pricks with a needle. The apparatus is suitable for use in sectors involving the design, manufacture, production or use of health-related devices. Specifically, the apparatus is particularly suited for use in hospitals, clinics, prisons, elderly nursing homes, vaccination campaigns, emergency situations, etc., and, in general, where it is necessary to apply therapies with intramuscular injections.

The invention belongs to the technical field of veterinary drug preparations, and discloses a veterinary avilamycin double-sustained-release microcapsule copolymer preparation, and every 100g of the copolymer preparation is prepared from the following components by weight: 8.0 to 16.0 g of avilamycin, 5.0 to 10.0 g of guinea pig fat, 2.0 to 8.0 g of peanut oil, 1.0 to 4.0 g of hydrogenated rosin ester, 15.0 to 35.0 g of benzylazine 35, 0.1 to 0.5 g of glutathione, 0.1 to 3.0 g of eisonian blue, 0.1 to 2.0 g of magnesium chloride and the balance of fructose. The main ingredient avilamycin of the preparation medicine exists in a micro-capsule co-polymer form, after intramuscular injection, the double-slow-release effect is presented on the local tissue, the medicine effect maintaining time is longer, the medicine bioavailability is higher, the administration frequency can be reduced, and the labor cost and the animal stress response are reduced. The invention further discloses a preparation method, the process operability is high, and the market prospect is wide.

The present invention relates to the use of botulinum toxin for the preventive treatment of migraine by intramuscular injection following specific dosing and injection schemes involving injection of botulinum toxin into the frontal, temporal, occipital and cervical areas of the head and, optionally, the shoulder area. The schemes are easy to inject and provide a new treatment approach in the preventive treatment of both episodic migraine (EM) and chronic migraine (CM).

The invention relates to an effective medicine for treating external impaired eyes of equus animals. The effective medicine is characterized by being prepared from 90 g of white chrysanthemum; , 30 g of rhizoma atractylodis, 30 g of flos eriocauli and 30 g of caulis akebiae; the traditional Chinese medicine is prepared from 25g of radix bupleuri, 25g of cicada slough, 25g of herba equiseti hiemalis, 25g of radix scutellariae, 25g of radix gentianae, 25g of semen cassiae torae, 25g of radix rehmanniae, 25g of liquorice root, 25g of cortex moutan and 25g of radix et rhizoma rhei powder. The use method comprises the following steps: grinding the raw materials into fine powder and adding 5-7 pieces of chicken egg white. And one pig bile is mixed and then drenched. The following therapy can be combined simultaneously, and the effect is optimal. The method comprises the following steps: carrying out subcutaneous injection on 5 pieces of vitamin B2 with the volume of 2ml once a day, and continuously using for three days. According to a blood therapy, 50 ml of blood is collected each time for intramuscular injection once every other day, and three times of intramuscular injection are continuously used. 2 ml of vitamin B2 is used for sealing three upper and lower eyelids twice in total. And washing with boric acid for 1-3 times every day. Through the treatment by the method, rehabilitation can be generally realized in half a month. The traditional Chinese medicine is used for clinically treating 31 pieces of horses, donkeys and snails, 28 pieces of horses, donkeys and snails are cured, the cure rate is 90.2%, and a relatively satisfactory effect is achieved.