62 results about "Precocious puberty" patented technology

The present compounds are intermediates for the preparation of quinoline derivatives and compositions having gonadotropin-releasing hormone antagonistic activity useful as propylactics or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, uterine or cervical cancer, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; are effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a male or female contraceptive, as an ovulation-inducing agent; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; and are useful for modulating estrous cycles in animals in the field of animal husbandry, as agents for improving the quality of edible meat or promoting the growth of animals, and as agents for promoting spawning in fish.

The present invention relates to an excellent-quality chicken maternal strain, in particular to a method for the strain breeding of the dark-shank spotty plumage chicken with dwarf gene, which belongs to the technical field of the dark-shank spotty plumage chicken with dwarf gene. The breeding procedures of the present invention are (1) selecting a cock of Chongren chicken and a hen having the dark-shank partridge in the grandparent hen group of the dwarf yellow-feather chicken as the breeding materials and selecting a normal-shaped cock having the dark-shank partridge character in the F1 generation after the hybridization of the cock and the hen; (2) Selecting the dark-shank partridge normal-shaped cock to be mated with the hen of the dark-shank partridge dwarf yellow-feather chicken and selecting the dark-shank partridge dwarf cock and the dark-shank partridge dwarf hen in the F2 generation; (3) cross-breeding and locking the selected dark-shank partridge dwarf cock and the dark-shank partridge dwarf hen so as to get the present invention after the breeding from generation to generation. Since the body of the maternal-strain chicken is short cultivated through the present invention, the chicken has the outstanding advantages of precocious puberty, high-yield of eggs and less feed consumption and cultivated space saving, which greatly reduces the production cost of the commodity generation chicken and improves the comprehensive benefit of the cultivation.

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The present invention relates to a novel class of AKR1C3 inhibitors, to compositions containing them, to methods for their preparation, and to methods of use thereof. The AKR1C3 inhibitors may be useful in the treatment of, for example, prostate cancer, benign prostate hyperplasia (BPH), lung cancer, acne, seborrhea, hirsuitism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, uterine cancer, uterine fibroids, endometriosis, myeloma and leiomyoma.

The invention discloses a method for cultivating large 3-age river crabs, which comprises the steps of selecting cultivation water areas, selecting and transporting pea crabs, primarily cultivating crab species, cultivating large crabs, cultivating the 3-age river crabs and the like. The method for cultivating the large 3-age river crabs relies on a matured juvenile-crab cultivating and adult-crab breeding technology at present, and the pea crabs are moved to high altitude areas to be cultured. By utilizing special natural conditions suitable for the river crab to grow in the high altitude areas, the pea crabs are cultivated into large crab species which are intensively cultivated in southern ponds, and the purpose of cultivating the large adult crabs is achieved accordingly. The problem that the size of the cultivated adult crabs is not ideal due to the germplasm problem is effectively solved, the problem that the adult crabs and the crab species have precocious puberty in the cultivating and breeding process is solved, the large-scale production of the cultivated large adult crabs can be achieved, and the economic benefit of river crab cultivation is further improved. In addition, the method for cultivating the large 3-age river crabs is simple in implementation, and the adult crabs cultivated by means of the method is larger than adult crabs cultivated by means of a common cultivating method.

To provide a novel and excellent method for treating and / or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17βHSD type 5.It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17βHSD type 5 and may become a therapeutic agent and / or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and / or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and / or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

The invention provides an additive for suppressing juvenile crab early maturity, including: VC phosphate, taurine, humic acid sodium, cholesterol, premix for crab, wheat-middlings, the components are as follows: 2-3 parts by weight of VC phosphate; 2-3 parts by weight of taurine; 3-4 parts by weight of humic acid sodium; 2-3 parts by weight of cholesterol; 18-22 parts by weight of premix for crab; 5-15 parts by weight of wheat-middlings. The invention optimizes feeding of suppressing juvenile crab from the point of improving the juvenile crab physiology, and is a feed additive containing juvenile crab early maturity suppressing factor, and has the functions of improving growth and suppressing juvenile crab early maturity, the good effects are as follows: 1) juvenile crab early maturity rate is reduced significantly, from the 18-25% before treatment to 5-8% after treatment; 2) the survival rate of the juvenile crab is improved from 12% to 15-20%; 3) the feed usage amount is reduced, the feed coefficient is reduced from 3.2 before adding to 2.4-2.6 after adding, the cultivation cost is reduced; 4) because the juvenile crab early maturity rate is reduced, the elimination rate is reduced, the average output of juvenile crab per mu is increased from 90-100kg to 125-140kg.

Disclosed are a gonadotropin releasing hormone receptor antagonist and a pharmaceutical composition including the same, which can be useful in preventing or treating a sex hormone-related disease such as endometriosis, amenorrhea, irregular menstruation, uterine myoma, uterine fibroids, polycystic ovarian disease, lupus erythematous, hypertrichosis, precocious puberty, short stature, acne, alopecia, gonadal steroid-dependent neoplasms, gonadotropin-producing pituitary adenoma, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hyperplasia, contraception, and infertility, as well as Alzheimer disease.

The invention discloses an SNP locus significantly relevant to the precocious puberty trait of eriocheir sinensis and the application. The SNP locus is positioned in a Vg gene 5'-flanking region-437bpposition of the eriocheir sinensis, and nucleotide variation information is SNP g.-437T) G. PCR primer used for detecting the SNP locus is SEQ ID NO.1 and SEQ ID NO.2, and restriction enzyme is MboI.The SNP locus has significant correlation with precocious puberty of the eriocheir sinensis, and the risk of precocious puberty trait of GG gene eriocheir sinensis individual is obviously smaller than that of precocious puberty trait of TT gene individual. The SNP locus and the PCR primer used for genetic typing are applied to the predication of the risk of precocious puberty of the eriocheir sinensis and / or the variety breeding of the eriocheir sinensis.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e,g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea sydrome, multilocular ovary sydrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention relates to the field of medicinal chemistry and in particular relates to 4-imidazolyl quinoline and quinazoline ketone aromatizing enzyme inhibitors. The invention further discloses a preparation method and pharmacological activity of the inhibitors, a medicinal composition containing the compounds as well as the medical application of the inhibitors, in particular the medical application of the inhibitors in preventing or treating estrogen maintaining diseases such as breast cancers, endometrial cancers, female sexual precocity, gynecomastia and the like.

The present invention discloses a eukaryotic expression method of molt-inhibiting hormone-1 gene of mitten crab, including the steps of constructing a eukaryotic expression vector of the molt-inhibiting hormone-1 gene of the mitten crab and eukaryotic expressing molt-inhibiting hormone-1 gene of the mitten crab. The eukaryotic expression method successfully expresses an MIH protein; provides a theoretical basis for further understanding the internal mechanism of the precocious crab gonad early development, understanding the function mechanism of the crab molt gland, and further establishing technical measures to control crab precocious puberty; and obtains artificial regulation basis of achieving growing development and reproduction.

The invention discloses a living molecular detection method for precocious puberty individual of Eriocheir sinensis. Full-length cDNA sequence of EsEcR gene is cloned from Eriocheir sinensis tissue by the use of primer groups provided by the invention. Based on the gene sequence, the invention provides a living molecular detection method for precocious puberty individual of Eriocheir sinensis. The invention not only provides a living molecular detection method for precocious puberty individual of Eriocheir sinensis, but also provides an important testing method for early detection of Eriocheir sinensis precocious puberty individual.

The compounds of the present invention possess excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc, or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The dandelion plant milk is compounded with plant material as main component and is a kind of children's food developed based on children's nutritional status and need for health. It is produced with lactic acid bacteria, fresh milk, dandelion, malt, radish seed and other green food material. It has balanced nutrients, and can promote children's digestion and absorption, raise children's immunity and prevent children's obesity and sexual precocity.

The compound of the present invention possesses excellent gonadotropin-releasing hormone antagonizing activity, and is useful for preventing or treating sex hormone-dependent diseases, e.g., sex hormone-dependent cancers (e.g., prostatic cancer, uterine cancer, breast cancer, pituitary tumor), prostatic hypertrophy, hysteromyoma, endometriosis, precocious puberty, amenorrhea syndrome, multilocular ovary syndrome, pimples etc. or as a pregnancy regulator (e.g., contraceptive), infertility remedy or menstruation regulator.

The invention discloses a microsatellite-labeled primer linked with precocious puberty or no precocious puberty of eriocheir sinensis and application thereof. The microsatellite-labeled primer is characterized in that 5 pairs of microsatellite primers are provided, wherein 2 microsatellite sites are linked with the precocious puberty character of the eriocheir sinensis; 3 microsatellite sites are linked with the normal character of the eriocheir sinensis; the primer can be used for identifying whether the eriocheir sinensis has the precocious puberty. The specific identification method comprises the following steps of: taking DNA of a gene group of the eriocheir sinensis to be identified, then carrying out PCR (Polymerase Chain Reaction) augmentation by 5 pairs of microsatellite primers, respectively carrying out polyacrylamide gel electrophoresis on augmentation products, then carrying out silver dyeing staining, and judging the condition of the precocious puberty of the eriocheir sinensis to be identified by the size of strips at different positions. The microsatellite-labeled primer and the application disclosed by the invention have the advantages that normal individuals without precocious puberty can be selected for culture in a targeted manner, so that the normal individuals can be prevented from mixing the young eriocheir sinensis of precocious puberty in the process of early culture, and the development of the eriocheir sinensis in China can be effectively improved.

The invention relates to a traditional Chinese medicine composition for treating sexual precosity including breast development of children. The traditional Chinese medicine composition is characterized in that effective components of the composition include radix bupleuri, poria cocos, stir-fried bighead atractylodes rhizomes, stir-fried white peony roots, radix glycyrrhizae preparata, mint, thunberg fritillary bulbs, stir-fried cowherb seeds, tangerine seeds, tribulus terrestris, malt and sinapis alba. The composition disclosed by the invention has the function of treating the sexual precosity including breast development of the children. The liver meridian and the stomach meridian pass through breasts, and the radix bupleuri, the mint, the tribulus terrestris, the stir-fried white peonyroots and the malt can soothe the liver and regulate qi; the thunberg fritillary bulbs, the stir-fried cowherb seeds, the tangerine seeds and the sinapis alba can eliminate stagnation and eliminate mass; and infantile spleen and stomach are delicate, the stir-fried bighead atractylodes rhizomes and the licorice roots are administrated to invigorate the spleen and harmonize the stomach, and the effects of soothing the liver, regulating qi, strengthening the spleen, regulating the function of the stomach, eliminating mass and eliminating stagnation can be comprehensively achieved. The effects and beneficial effects on human bodies of the composition prepared from single agents in a certain proportion are much better than those of single agents. The composition is simple in production technology, easy to take and notable in treatment effects, and is an ideal traditional Chinese medicine composition for treating the sexual precosity including breast development of the children.

Spiroindoline derivatives, processes for their preparation and pharmaceutical compositions thereof, their use for the treatment of diseases, and their use for the manufacture of medicaments for the treatment of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine leiomyoma (fibroids), polycystic ovarian disease, menorrhagia, dysmenorrhea, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception, infertility and assisted reproductive therapy such as in vitro fertilization. The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

A gonadotropin-releasing hormone antagonistic composition, which comprises an optionally substituted condensed-bicyclic compound consisting of a homo or hetero 5 to 7 membered ring and a homo or hetero 5 to 7 membered ring is effective as a propylactic or therapeutic agent for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, pplycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); can be used as a contraceptive of male or female, as an ovulation-inducing agent of female; can be used as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent fro improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.

The invention provides a production method of Oncorhynchus Mykiss triploid fry. The production method including fertilizing fertilized eggs of Oncorhynchus Mykiss for 12-14 min at the temperature of 7 DEG C to transfer to 240mg / L 6-DMAP (6-Dimethylaminopurine) solution at temperature at 12-14 DEG C for soaking for 14-16 min, and then transferring the fertilized eggs to hatching water to hatch normally. After around 50 days, the Oncorhynchus Mykiss triploid fry are hatched from the fertilized eggs. Eyeing rate of the fertilized eggs during hatching is more than 68%, hatching rate of the fry reaches 90%, the fry are detected by a flow cytometry, rate of triploid reaches 81%. By the aid of the production method of the Oncorhynchus Mykiss triploid fry, the problems of precocious puberty, individual miniaturization, disease breeding and the like on cultivation individuals due to long-term inbreeding and lack of systematic select breeding during cultivation of the Oncorhynchus Mykiss, and the production method has good market value.

The invention provides a traditional Chinese medicine composition for inhibiting early development and sexual precocity of children and a preparation method and application of the traditional Chinesemedicine composition. The traditional Chinese medicine composition is prepared from 5-20 parts of rhizoma polygonati, 5-20 parts of poria cocos, 5-20 parts of rhizoma dioscoreae, 3-12 parts of fructusgardeniae, and 22-88 parts of malt. The preparation method comprises the following steps: extracting the traditional Chinese medicine composition with water or ethanol, conducting concentrating, filtering with a ceramic membrane, sequentially adsorbing with a medium-polarity macroporous adsorption resin column and a polyamide column, eluting with water, and eluting with 40%-70% ethanol, collecting the eluent, concentrating the eluent under reduced pressure, and then spray-drying the concentrate to obtain a fine powder. The above traditional Chinese medicine composition is applied to medicineand food for inhibiting early development and sexual precocity of children, can inhibit early development and sexual precocity of children, and is low in price and free of side effects.

The invention discloses a medicine composition for treating infantile precocious puberty and a preparation method thereof. The medicine composition is prepared from the following medicinal raw materials: radix rehmanniae recen, rhizoma alismatis, cortex lycii radicis, moutan bark, felwort, selfheal, malt, turtle shell, chrysanthemum, kelp, radix scrophulariae, endothelium corneum gigeriae galli and oyster. The preparation method comprises the following steps: S1, decocting malt for 2-5 times, mixing the decoctions, filtering; adding alcohol which has equal amount as the filtrate into the filtrate, stirring the mixed solution, and standing overnight; reclaiming alcohol from the supernate until no alcohol smell exists; S2, grinding turtle shell and oyster into powder, filling cloth bags with the powder, and decocting together with other medicinal materials with water for 2-5 times, mixing the decoctions, filtering, and standing the filtrate overnight; and S3, taking the supernate of the filtrate in the S2, adding the supernate into the S1, filtering, and performing post processing to obtain the medicinal composition. The medicine composition has the effects of clearing liver, eliminating stagnation, nourishing yin and purging internal fire, can be used for treating infantile breast distending pain and vaginal bleeding, and has the effect of treating infantile precocious puberty.

The invention discloses bone collagen and poria cocos paste for treating child sexual precocity and adolescent development retardation, and the bone collagen and poria cocos paste is prepared from the following raw materials in parts by mass: 450-550 g of bone collagen peptide, 450-550 g of walnut peptide, 950-1,100 g of poria cocos, 450-550 g of hawthorn, 950-1,100 g of malt, 950-1,100 g of lotus seed, 450-550 g of endothelium corneum gigeriae galli and 950-1,100 g of honey. The paste is reasonable in formula and scientific in compatibility, the bone collagen peptide promotes bone development and enhances bone growth, the walnut peptide improves memory, develops intelligence and improves human immunity, the poria cocos promotes diuresis and excretes dampness, strengthens spleen and calms heart, the hawthorn promotes digestion and strengthens stomach, promotes qi circulation and dissipates blood stasis, dissolves turbidity and reduces lipid, the malt promotes qi circulation and digestion, strengthens spleen and stimulates appetite, delactates and eliminates distension, and the lotus seeds tonify spleen, stop diarrhea, stop leucorrhea, tonify kidney and arrest seminal emission. The endothelium corneum gigeriae galli has the effects of invigorating stomach, promoting digestion, arresting seminal emission, treating stranguria and dissolving stones. The medicinal materials are combined to promote the absorption of nutritional ingredients, promote the growth and intelligence development of teenagers and children, and have a treatment effect on sexual precocity of children and development retardation of teenagers.

The invention relates to a seaweed DHA brain invigorating health care product. The composition formula of the seaweed DHA brain invigorating health care product comprises hickory nuts, yams, tremella, vines of multiflower knotweed and seaweed DHA microcapsule powder. The seaweed DHA brain invigorating health care product is a product which is suitable for most people and various ages, has basically no toxic and side effect, does not cause child precocious puberty harm, can meet the requirement that people rapidly recover the physical power through a simple and convenient method, is capable of invigorating brain and benefiting intelligence and convenient to eat and has the effects that getting angry is not prone to happening, and long-term taking can be achieved, and the seaweed DHA brain invigorating health care product is especially an excellent brain invigorating food-medicine health care product for the old and children who are weak in spleen and stomach function and for patients who are low in spleen and stomach function.

The invention discloses a formula of gardenia jasminoides granules. The formula comprises the following raw medicinal materials: 3 to 9 grams of radix bupleuri, 7 to 13 grams of fructus gardeniae, 7 to 13 grams of radix scutellariae, 3 to 9 grams of cortex moutan, 7 to 13 grams of radix curcumae, 7 to 13 grams of rhizoma cyperi, 7 to 13 grams of fructus trichosanthis, 7 to 13 grams of spica prunellae, 7 to 13 grams of bulbus fritillariae thunbergii, 7 to 13 grams of semen litchi, 7 to 13 grams of rhizoma atractylodis macrocephalae, 3 to 9 grams of pericarpium citri reticulatae, 3 to 9 grams of rhizoma pinelliae preparata and 7 to 13 grams of radix paeoniae alba. The formula of the gardenia jasminoides granules can be used for treating idiopathic central precocious puberty, delaying premature development of a second sexual character and avoiding early maturity of bones and sexual organs, so that the treatment purposes of delaying the closing time of epiphysis and ovulation time of ovaries and improving the expected height and fertility function of sick children are achieved.