8 results about "Total hemoglobin" patented technology

The invention relates to the technical field of glycosylated hemoglobin detection, in particular to a glycosylated hemoglobin detection method based on magnetic bead affinity adsorption, which comprises the following steps: A, sample pretreatment; b, total hemoglobin detection: detecting the absorbance H1 of the sample after hemolysis; c, carrying out affinity reaction; d, magnetic separation: starting an electromagnet tightly attached to the wall of the cuvette, and adsorbing the functionalized magnetic beads to the wall of the cuvette by adopting the electromagnet; e, non-glycosylated hemoglobin detection: detecting the absorbance H2 of the supernatant under the same optical path; and F, result calculation: calculating according to a formula HbA1c% = (H1-H2) / H1 * 100% to obtain a detection value of glycosylated hemoglobin. The glycosylated hemoglobin detection method disclosed by the invention is simple and convenient to operate, low in cost and very easy to realize automation. Compared with other high performance liquid chromatography methods for detecting glycosylated hemoglobin, the cost of a detection instrument is reduced by 70%, and the cost of a single test reagent is reduced by 30%.

The invention relates to a photoelectric detection system and method for hemoglobin detection, and relates to the technical field of spectral analysis and biomedical engineering. The method mainly comprises the following steps: controlling a light source module in the buckle type shell structure to emit light with different wavelengths, and enabling the light to penetrate through a blood transfusion tube and blood placed in the buckle type shell structure; a photoelectric detector module in the buckle type shell structure is controlled to obtain the blood transmission light intensity of the multi-wavelength light to the blood transfusion tube; calculating basic absorbance corresponding to the first wavelength and the second wavelength by using a hemoglobin absorption model, and correcting the basic absorbance by using a correction model to obtain final absorbance; according to the final absorbance corresponding to the first wavelength and the final absorbance corresponding to the second wavelength and the effective optical path length, predicting the concentration of deoxyhemoglobin and the concentration of oxyhemoglobin; and adding the deoxyhemoglobin concentration and the oxyhemoglobin concentration to obtain the total hemoglobin concentration.

According to the real-time bleeding monitoring method and device based on the spectrometry, the equipment and the storage medium, the drainage container is clamped through the intelligent detection clamp, the instantaneous flow and the corresponding actual absorbance data of the drainage container under the reference wavelength and the multiple different specified wavelengths are collected in real time, and collection is convenient and fast; according to all actual absorbance data and the hemoglobin concentration quantitative analysis model, the current hemoglobin concentration is determined objectively, accurately and efficiently; according to the current hemoglobin concentration and the instantaneous flow, the hemoglobin loss rate and the total hemoglobin loss amount are determined in real time, according to the hemoglobin loss rate and the total hemoglobin loss amount, first grading early warning is carried out, and systolic pressure and heart rate are collected in real time; according to the hemoglobin loss total amount, the systolic pressure and the heart rate, the second grading early warning is carried out, and real-time precise double grading early warning is convenient for related personnel to timely and accurately evaluate the bleeding condition and take corresponding measures.

The present invention relates to a non-invasive method for determining and / or predicting total Hb (g) and / or total iron (mg) in a unit of packed red blood cells (pRBC). The method preferably further includes assigning the unit of pRBC to a group of pRBCs suitable for transfusion. The method can furthermore be automated. Additional aspects relate to a data processing apparatus comprising means for carrying out the method, a computer program and a computer-readable medium.

Methods and apparatus for multi-wavelength (MW) photoplethysmography (PPG)-based trend monitoring are used to monitor changes in total hemoglobin, fluid accumulation in circulation (plasma volume) and tissues (interstitial fluid volume), total blood volume, and tissue perfusion (microcirculation). The methods and systems provide integration of automated decision support in both medical-grade and non-medical grade wearables for continuous body fluid management guided by MW PPG measurements. Recommendations for optimizing physiological function, including management of fluid intake, restriction or removal, co-administration of cardiovascular medication, and red blood cell transfusion may be provided. Blood loss detection and transfusion-related recommendations may be made based in assessing whole-body hemoglobin mass changes by differentiating dilution-related variations in hemoglobin concentration from net changes in hemoglobin mass due to red blood cell loss or transfusion. Plasma dilution-related fluctuations in plasma volume and corresponding blood volume changes may also be monitored alongside fluctuations in tissue fluid volume and transcapillary fluid shifts. The system may provide clinically relevant trend data for clinician interpretation and real-time alerts for assessing fluid status, including intravascular and extravascular fluid accumulation, total blood volume changes, plasma volume, and net hemoglobin mass variations. Clinical guidance on fluid management, real-time alerts for imminent edema or dehydration risks, and notifications regarding potential blood loss or transfusion effects on hemoglobin levels may be provided. In a non-clinical setting, the system advises on fluid intake or restriction based on fluid accumulation trends in circulation and tissues which are an indication of plasma and tissue hydration status, and prompts users to seek medical attention when a significant reduction in hemoglobin is detected.

Methods and apparatus for multi -wavelength (MW) photoplethysmography (PPG)-based trend monitoring are used to monitor changes in total hemoglobin, fluid accumulation in circulation (plasma volume) and tissues (interstitial fluid volume), total blood volume, and tissue perfusion (microcirculation). The methods and systems provide integration of automated decision support in both medical-grade and non-medical grade wearables for continuous body fluid management guided by MW PPG measurements. Recommendations for optimizing physiological function, including management of fluid intake, restriction or removal, co-administration of cardiovascular medication, and red blood cell transfusion may be provided. Blood loss detection and transfusion- related recommendations may be made based in assessing whole-body hemoglobin mass changes by differentiating dilution-related variations in hemoglobin concentration from net changes in hemoglobin mass due to red blood cell loss or transfusion. Plasma dilution-related fluctuations in plasma volume and corresponding blood volume changes may also be monitored alongside fluctuations in tissue fluid volume and transcapillary fluid shifts. The system may provide clinically relevant trend data for clinician interpretation and real-time alerts for assessing fluid status, including intravascular and extravascular fluid accumulation, total blood volume changes, plasma volume, and net hemoglobin mass variations. Clinical guidance on fluid management, real-time alerts for imminent edema or dehydration risks, and notifications regarding potential blood loss or transfusion effects on hemoglobin levels may be provided. In a non-clinical setting, the system advises on fluid intake or restriction based on fluid accumulation trends in circulation and tissues which are an indication of plasma and tissue hydration status, and prompts users to seek medical attention when a significant reduction in hemoglobin is detected.

The application discloses a preparation method of a ratio type electrochemical sensor for synchronous detection of total hemoglobin (tHb) and glycosylated hemoglobin (HbA 1c ) "double signal opening". The application also discloses a method for synchronous quantitative detection of tHb and HbA 1c by using the ratio type sensor, and application of the method to accurate quantitative determination of blood sugar in a whole blood sample. Experimental results show that the ratio type "double signal opening" electrochemical sensor constructed by the application has high accuracy, high selectivity, high sensitivity and good anti-interference performance, and is suitable for accurate evaluation of tHb and HbA 1c in a clinical blood sample.

This application discloses a dual-wavelength time-domain blood oxygen detection system, method, device, and medium, belonging to the fields of optics and biomedical engineering. The system includes a signal generator, a timing controller, two pulsed lasers, an optical fiber coupler, a silicon photomultiplier tube, a signal frequency multiplier, and a time-correlated single-photon counter. The timing controller achieves interleaved excitation of dual-wavelength pulses, and the coupler separates 1% reference light and 99% probe light. At the detection end, the single-photon counter labels photons according to the excitation sequence, filters out shallow noise, and accumulates to construct a dual-wavelength photon histogram. Combined with finite element forward modeling based on the diffusion equation and Robin boundary conditions, the tissue absorption and scattering coefficients are simultaneously inverted, and the total hemoglobin concentration and blood oxygen saturation are calculated by modifying the Lambert-Beer law. This application achieves high-speed acquisition and high-precision reconstruction under the same physiological conditions with dual wavelengths, overcoming the problems of large dynamic errors and strong shallow interference in traditional systems.