2 results about "Total hemoglobin" patented technology

The application discloses a preparation method of a ratio type electrochemical sensor for synchronous detection of total hemoglobin (tHb) and glycosylated hemoglobin (HbA 1c ) "double signal opening". The application also discloses a method for synchronous quantitative detection of tHb and HbA 1c by using the ratio type sensor, and application of the method to accurate quantitative determination of blood sugar in a whole blood sample. Experimental results show that the ratio type "double signal opening" electrochemical sensor constructed by the application has high accuracy, high selectivity, high sensitivity and good anti-interference performance, and is suitable for accurate evaluation of tHb and HbA 1c in a clinical blood sample.

This application discloses a dual-wavelength time-domain blood oxygen detection system, method, device, and medium, belonging to the fields of optics and biomedical engineering. The system includes a signal generator, a timing controller, two pulsed lasers, an optical fiber coupler, a silicon photomultiplier tube, a signal frequency multiplier, and a time-correlated single-photon counter. The timing controller achieves interleaved excitation of dual-wavelength pulses, and the coupler separates 1% reference light and 99% probe light. At the detection end, the single-photon counter labels photons according to the excitation sequence, filters out shallow noise, and accumulates to construct a dual-wavelength photon histogram. Combined with finite element forward modeling based on the diffusion equation and Robin boundary conditions, the tissue absorption and scattering coefficients are simultaneously inverted, and the total hemoglobin concentration and blood oxygen saturation are calculated by modifying the Lambert-Beer law. This application achieves high-speed acquisition and high-precision reconstruction under the same physiological conditions with dual wavelengths, overcoming the problems of large dynamic errors and strong shallow interference in traditional systems.