175 results about "Hemoglobin hb" patented technology

The invention discloses an endoscope image processing method based on oxyhemoglobin saturation and multiple central wavelengths, and relates to the field of medical image processing.The method comprises the steps that a first initial image signal, a second initial image signal, a third initial image signal and a fourth initial image signal are obtained; calculating oxyhemoglobin concentration information of the target part according to the second initial image signal and the third initial image signal; calculating deoxidized hemoglobin concentration information of the target part according to the second initial image signal and the fourth initial image signal; calculating the oxyhemoglobin saturation of the target part according to the oxyhemoglobin concentration information and the deoxidized hemoglobin concentration information; performing brightness enhancement on the second initial image signal based on the oxyhemoglobin saturation to obtain a second enhanced image signal; and generating a target image according to the second enhanced image signal, the first initial image signal and the third initial image signal, wherein the target image is used for identifying the bleeding position of the target part.

The invention belongs to the technical field of biology, and particularly discloses a high-density fermentation method and application of recombinant spider silk protein, and the high-density fermentation method comprises the following steps: firstly, transforming an expression vector carrying spider silk protein genes into modified pichia pastoris cells to obtain a strain; the activated strain is subjected to expanding culture, high-density fermentation culture and purification, and recombinant spider silk protein is obtained; wherein the transformation means of the pichia pastoris cell is to integrate Vitreoscilla hemoglobin Vhb gene into the pichia pastoris cell by utilizing a gene recombination technology, and the expression of the Vitreoscilla hemoglobin Vhb gene is improved by carrying out metabolic engineering transformation on the pichia pastoris cell for expression and optimizing the regulation and control of staged fermentation parameters, so that the expression efficiency of the Vitreoscilla hemoglobin Vhb gene is improved. The problems that in existing recombinant protein fermentation, oxygen dependence is high, product degradation is serious, purity is low, and large-scale stability is poor are solved, the yield and purity of recombinant spider silk protein are guaranteed, and large-scale production of the recombinant spider silk protein is facilitated.

The invention discloses a Yarrowia lipolytica engineering bacterium for producing astaxanthin in a peroxisome compartment and application of the Yarrowia lipolytica engineering bacterium. A complete astaxanthin synthesis path is expressed in host bacteria by recombinant Yarrowia lipolytica; comprising geranyl geranyl diphosphate synthase CrtE, phytoene synthetase / lycopene cyclase CrtYB, phytoene desaturase CrtI, 3-hydroxy-3-methylglutaryl CoA reductase tHMGR, beta-carotene ketolase CrtW and beta-carotene hydroxylase CrtZ, and the enzymes are relocated into peroxisome, so that the enzyme activity of the peroxisome is improved, and the enzyme activity of the peroxisome is improved. The number of expression hemoglobin genes VHb and peroxisome is increased, the surface area of the hemoglobin genes VHb is enlarged, and one or more of enzymes PEX11, PEX19, DNM1 or PHO85 for prolonging the service life of the hemoglobin genes VHb and peroxisome is / are obtained; the astaxanthin production performance of the recombinant strain is verified based on cytoplasm engineering and subcellular organelle compartment engineering, and the astaxanthin production capacity of the yarrowia lipolytica is further improved.

The invention provides multifunctional bionic hydrogel as well as preparation and application thereof in traumatic brain injury treatment, and belongs to the field of biomedical materials. The preparation method comprises the following steps: combining polydopamine modified hemoglobin nanoparticles with curcumin-based carbon quantum dots with anti-inflammatory activity, and embedding into bionic hyaluronic acid-collagen double-network hydrogel, so as to prepare the multifunctional bionic hydrogel. The hydrogel can effectively relieve neuron hypoxia, reduce apoptosis, promote the polarity of microglial cells to be converted into anti-inflammatory phenotype, and significantly down-regulate the expression of S100A8, thereby inhibiting pathological neural immune crosstalk. In a traumatic brain injury model, hydrogel implantation improves the pathological microenvironment, enhances endogenous nerve regeneration, and ultimately results in significant neurological function and cognitive recovery. The multifunctional bionic hydrogel prepared by the invention has a good application prospect in preparation of materials for preventing and / or treating traumatic brain injury.

The invention discloses a hand motion FNIRS signal classification method based on t distribution optimization feature extraction, and the method specifically comprises the steps: employing a portable functional near-infrared collection device to collect an optical density signal of a forehead cortex brain region during the motion execution period during the operation of the device; after pretreatment, the concentration of oxyhemoglobin HBO and the concentration of deoxidized hemoglobin HBR are calculated according to the corrected Beer-Lambert law; according to motion execution and resting state segmentation data, time domain features and time-frequency domain features of oxyhemoglobin concentration data signals of each channel of each experiment test are extracted, and a first feature matrix is formed; performing kernel density estimation and kurtosis and skewness test on the first feature matrix to obtain a second feature matrix, performing t distribution on each corresponding feature satisfying normal distribution in the second feature matrix of the motion execution and resting states, and optimizing feature selection on the basis to obtain an optimized third feature matrix; the optimized third feature matrix is used as classifier input, a brain-computer interface system model training result is obtained, and effective feature selection and extraction are achieved; according to the method, the brain-computer interface system feature extraction of the hand motion FNIRS signals can be optimized, so that the classification performance is improved.

The invention relates to the field of molecular biology, and discloses a nucleic acid releasing agent for isothermal amplification and a use method of the nucleic acid releasing agent. Comprising the following steps: step 1, preparing a polyoxypropylene polyoxyethylene copolymer diluent, a defoaming agent SE-15 diluent, an ethyl phenyl polyethylene glycol NP-40 diluent, a sodium polyethylene sulfonate diluent and a Proclin300 diluent in sequence through RNA enzyme-free water; and 2, sequentially preparing an ethylenediamine tetraacetic acid disodium salt mother solution, a sodium dodecyl sulfate mother solution and a glycine mother solution through RNA enzyme-free water. Sodium polyethylene sulfonate can be specifically combined with protein amplification inhibitors in a sample to remove mucoprotein, hemoglobin, polysaccharide and other inhibitors in the swab sample, and disodium ethylene diamine tetraacetate can chelate metal ions to reduce the influence of nuclease on target nucleic acid.

The invention provides a mobile terminal skin parameter inversion method based on spectral information, and the method comprises the following steps: constructing an optical model according to the characteristics of a skin layered structure and a spectral response mechanism of three skin parameters: melanin content, hemoglobin concentration and dermis thickness, and building a skin parameter and reflection spectrum database based on the model; based on the database, establishing a skin multi-parameter inversion MLP neural network structure adaptive to the collection characteristics of a mobile phone end sensor, and screening an optimal four-waveband channel through multi-waveband combination traversal; the mobile phone spectrum sensor is subjected to wave band optimization, data acquisition and skin parameter inversion. According to the method, through efficient decoupling of a nonlinear coupling relation among multiple skin parameters by waveband optimization and an MLP model, and targeted design of four optimal visible light narrow-band channels, synchronous quantitative detection of melanin, hemoglobin and dermis thickness is realized, core physiological parameters from epidermis to dermis superficial layer are covered, information coverage is comprehensive, and specificity is high.

The utility model relates to the technical field of livestock and poultry blood utilization, in particular to a hemoglobin low-temperature extraction device which adopts two-stage separation and integrated design, is high in integration level, suitable for small-scale hemoglobin extraction work and good in practicability. Comprising a tank; the storage crushing tank is installed on the upper portion of the tank body, the liquid inlet pipe is installed on the top of the storage crushing tank, the first centrifugal separation tank is installed in the middle of the tank body, the storage crushing tank is communicated with the first centrifugal separation tank through a pipeline, and the second centrifugal separation tank is installed in the middle of the storage crushing tank through a pipeline. A residue discharging pipe is installed on the side wall of the first centrifugal separation tank, the upper end of the conveying pipe is communicated with the first centrifugal separation tank, the second centrifugal separation tank is installed on the lower portion of the tank body, a first liquid discharging pipe is installed on the side wall of the second centrifugal separation tank, and the upper end of the second liquid discharging pipe is communicated with the bottom of a second separation cavity of the second centrifugal separation tank. The upper end of the second liquid discharging pipe is located on the inner side of the inner end of the first liquid discharging pipe.

The application discloses a use of Ejiao Qianggu oral liquid in regulating immunity, and particularly relates to an improving effect of the Ejiao Qianggu oral liquid on an immune system, which is realized by the following aspects. On one hand, the Ejiao Qianggu oral liquid promotes proliferation and transformation (mainly early T lymphocytes and part of B lymphocytes) and active functions of spleen lymphocytes; on the other hand, the Ejiao Qianggu oral liquid improves phagocytosis of macrophages. The Ejiao Qianggu oral liquid has the following characteristics: firstly, the Ejiao Qianggu oral liquid acts on early lymphocyte maturation, and has no significant effect on proliferation of peripheral blood lymphocytes; secondly, the Ejiao Qianggu oral liquid can significantly act on immune target organs, thymus and spleen tissues, and does not excessively stimulate the spleen, unlike positive drugs such as colony stimulating factor which can cause significant edema of the spleen; and thirdly, the Ejiao Qianggu oral liquid has a significant recovery effect on body weight, white blood cells, lymphocytes, red blood cells and hemoglobin in blood of patients with low immunity.

The invention provides a sugar fat disease death risk prediction method and system based on NHANES data, and the method comprises the steps: obtaining the fasting blood glucose FPG and glycosylated hemoglobin HbA1c clinical detection data of a sugar fat disease patient, and calculating an SHR value through a formula; based on the data of the NHANES database, SHR total cause bilateral critical values of total cause death rate and cardiovascular death rate, SHR cardiovascular bilateral critical values and SHR cancer unilateral critical values of cancer death rate are obtained; and comparing the SHR value with an SHR total cause double-side critical value, an SHR cardiovascular double-side critical value and an SHR cancer single-side critical value of the cancer death rate, and carrying out risk layering and evaluation. The biochemical aging acceleration index has a prediction effect on the diabetes death risk, and KDMAgeAccel significantly intermediates the death risk caused by SHR.

This invention discloses a method for preparing a core-shell microneedle patch loaded with dual nanoparticles, comprising: preparing silica nanoparticles loaded with oxyhemoglobin and dihydroporphyrin e6; preparing calcium carbonate nanoparticles loaded with aPD-1 antibody; dispersing the silica nanoparticles loaded with oxyhemoglobin and dihydroporphyrin e6 in a polyvinyl alcohol solution to prepare the shell structure of the microneedles; preparing a polymer hydrogel; dispersing the calcium carbonate nanoparticles loaded with aPD-1 antibody in the polymer hydrogel to prepare the core structure of the microneedles; and casting the polyvinyl alcohol solution onto the backing of the microneedles to finally obtain the core-shell microneedle patch loaded with dual nanoparticles. The core-shell microneedle patch loaded with dual nanoparticles prepared by this invention can deliver nanoparticles to the tumor site, where the nanoparticles respond to the tumor microenvironment and activate the body's own immune system, thereby achieving a therapeutic effect on tumors.

The application belongs to the technical field of biological medicine, and particularly relates to a preparation method and application of a styrene microsphere for glycosylated hemoglobin detection. The styrene microsphere is prepared through a dispersion polymerization method, a seed polymerization method and a preparation step of organic high molecular particles. The microsphere prepared in the application has moderate particle size and concentrated distribution, good uniformity of the microsphere particle size, a hydroxyl covering on the surface of the microsphere to form a hydrophilic layer, and can effectively reduce the matrix effect, so as to achieve accurate analysis of glycosylated hemoglobin HbA1c. The result is accurate, stable and small in error in the detection, and the application can be applied to quantitative detection of diabetes.

The invention relates to the technical field of pharmaceutical preparations, in particular to composite condensing gel based on photodynamic therapy and a preparation method of the composite condensing gel. The preparation method of the composite condensate gel based on photodynamic therapy comprises the following steps: preparing a BSA (Bovine Serum Albumin) solution, uniformly mixing an inulin mother solution with the BSA solution, adjusting the pH value, heating in a water bath, cooling to room temperature, adding 5-aminolevulinic acid methyl ester hydrochloride into the condensate gel, adding an acid coagulant, diluting, and filling CO2 gas. According to the invention, CO2 is added into the composite condensation gel, so that the binding force of hemoglobin and O2 in tissues absorbing the composite condensation gel is reduced, and the concentration of free oxygen is improved, so that the composite condensation gel can transfer energy to surrounding oxygen and generate singlet oxygen with strong activity, thereby killing cancer cells and achieving the effect of improving the curative effect of photodynamic therapy.

The invention relates to the technical field of pickling of meat products, and discloses an internal and external coloring pickling process of meat products, which comprises the following steps: firstly collecting blood of a meat product to be pickled, separating blood cells from plasma by adopting a centrifugal separation method, and then carrying out hemolysis treatment on the blood cells by utilizing an acidic buffer solution. According to the internal and external coloring and pickling process of the meat product, processing equipment, a natural coloring agent, a natural preservative and a natural pickling agent are adopted, and when hemoglobin pigment is extracted, centrifugal separation and ion exchange chromatography technologies are applied, so that high purity of the pigment is ensured, and a basis is provided for stable internal coloring. In the rolling and pickling link, composite natural microorganism fermentation pickling liquid is used, components of the composite natural microorganism fermentation pickling liquid are carefully screened and cultured, microorganisms such as lactic acid bacteria and the like and metabolite antibacterial polypeptides thereof not only can inhibit growth and reproduction of harmful microorganisms, but also can enable meat products to uniformly absorb components such as salt and spices in the pickling process, so that the meat products are not prone to damage. And the quality difference caused by non-uniform pickling is effectively avoided.

The invention relates to a glycosylated hemoglobin HbA1c freeze-drying detection reagent and a preparation method and application thereof.The preparation method comprises the steps that surface aminated polystyrene microspheres are prepared through an emulsion polymerization method, then double bonds are introduced through Schiff base reaction and methylacrolein reaction, and the glycosylated hemoglobin HbA1c freeze-drying detection reagent is obtained. Then preparing anionic polystyrene microspheres with hydrophilic chains through free radical polymerization, and preparing freeze-dried powder of the HbA1c detection reagent R1 by adopting the anionic polystyrene microspheres; the preparation method comprises the following steps: preparing a hydrophilic cross-linking agent 2, 5-bis (2, 4-dihydroxy-6-formylphenoxy) terephthalaldehyde, then carrying out a Schiff base reaction on the hydrophilic cross-linking agent 2, 5-bis (2, 4-dihydroxy-6-formylphenoxy) terephthalaldehyde and HbA1c mAb to prepare an HbA1c oligomer, and preparing the HbA1c detection reagent R2 freeze-dried powder by using the HbA1c oligomer. The glycosylated hemoglobin HbA1c freeze-drying detection reagent prepared by the invention has the advantages of high antigen binding efficiency, excellent detection sensitivity, sufficient retention of antibody activity and strong detection specificity.

The invention discloses a functional feed additive for relieving hypoxia stress of dairy cows in a perinatal period, and belongs to the technical field of functional feed additives. The functional feed additive is composed of amino acid chelated iron, a nutrition carrier and water, the iron content is larger than or equal to 9%, and the arginine content is larger than or equal to 10%. The recommended daily supplement dosage is 6.6 g / head, the feed is fed in three times after being mixed with basic ration, and the service cycle is from 21 days before delivery to 21 days after delivery. The additive can significantly improve the hemoglobin concentration and blood oxygen transport capacity of the perinatal dairy cow, relieve hypoxia stress, improve the lactation performance, optimize the metabolic state and enhance the anti-oxidation and anti-inflammatory capacity, is clear in action mechanism, safe and efficient, and is suitable for healthy breeding and production performance improvement of the perinatal dairy cow.

1. Name of the product in this design: Graphical User Interface for Blood Sample Analysis of Electronic Device. 2. Purpose of this design: An electronic device. 3. The key design feature of this product is its graphical user interface. 4. The image or photograph that best illustrates the design's key features: the front view. 5. The product carrier uses a conventional design, omitting the rear view, left view, right view, top view, and bottom view. 6. Uses of the graphical user interface: for data analysis functions such as blood cell counting, white blood cell differential, and hemoglobin concentration measurement. 7. Human-computer interaction method of graphical user interface: The main view is the blood sample information and parameter results interface. Clicking "Start Test" on this interface will enter the change state diagram 1 to display patient information. Clicking "Next" on this interface will enter the change state diagram 2 to display test items. Clicking "Next" on this interface will enter the change state diagram 3 to display test status. 8. Other situations requiring explanation: In the change state diagram 1, the light yellow covered area represents the content screen, and the design for which protection is sought does not include color.

The application provides a double-layer structure colorimetric test paper for medical equipment occult blood detection and a preparation method and application thereof, and belongs to the technical field of hospital infection control and cleaning quality monitoring. The colorimetric test paper adopts a double-layer structure design: the bottom layer is obtained by immersing qualitative filter paper in immersion liquid A and drying, and is used for storing oxidant stably; and the upper layer is formed by uniformly coating coating liquid B on the surface of the bottom layer, and is used as a chromogenic substrate layer. When in use, hemoglobin remaining on the surface of the medical equipment can catalyze H2O2 in the bottom layer to oxidize TMB in the upper layer, a blue color reaction is generated, and naked-eye visual judgment is realized. The test paper physically separates the oxidant and the substrate, significantly improves the storage stability and detection sensitivity, and has the advantages of simple preparation process, low cost, convenient operation, and the like. The test paper is suitable for on-site rapid evaluation of cleaning effects of surgical instruments, endoscopes and the like, and has good clinical application prospect and popularization value.

The blood glucose, uric acid and hemoglobin analyzer comprises an upper shell, a lower shell and a placement cavity formed by the upper shell and the lower shell, a test paper insertion opening is formed in one side of the upper shell, a display window and a button through hole are formed in the top end of the upper shell, and a display screen, a control mainboard, a first button, a second button and a card withdrawing key are arranged in the placement cavity. The bottom surface of the display screen is electrically connected with the control mainboard through a conductive adhesive tape, the first button and the second button are both electrically connected with the control mainboard, a test paper clamping groove is formed in the upper surface of one side of the control mainboard, the control mainboard is connected with the upper shell through screws, a kidney-shaped hole is formed in the lower shell, and the card withdrawing key is in sliding connection with the kidney-shaped hole. The blood glucose, uric acid and hemoglobin detector has the advantages that the blood glucose, uric acid and hemoglobin detection functions are integrated, the blood glucose, uric acid and hemoglobin detector is small and exquisite in overall size design and convenient to carry by a user, the production cost is reduced on the premise that the detection precision is guaranteed, and large-scale popularization is facilitated.

The present invention relates to a measurement device for analyzing cells, the measurement device comprising: an electric measurement unit that electrically measures cells; a first optical measurement unit that optically measures cells; a second optical measurement unit that optically measures hemoglobin; a sample preparation unit that mixes a first fluorescent dye and a second fluorescent dye with a specimen to prepare a measurement sample; and an analysis unit that provides a measurement result of the measurement sample. The first optical measurement unit measures an optical signal including at least one of a first fluorescent signal generated from the first fluorescent dye and a second fluorescent signal generated from the second fluorescent dye. The analysis unit refers to the optical signal and classifies cells by executing an analysis based on differences in staining characteristics and fluorescence characteristics of the fluorescent dyes.

The invention relates to the technical field of non-invasive glycosylated hemoglobin detection, and discloses non-invasive glycosylated hemoglobin detection test paper and method.The non-invasive glycosylated hemoglobin detection test paper comprises a sampling layer, a combination cushion layer is bonded to the lower surface of the sampling layer, and a nitrocellulose membrane layer is bonded to the side face, away from the sampling layer, of the combination cushion layer; a water absorption layer is adhered to one side surface, far away from the combined cushion layer, of the nitrocellulose membrane layer; a PVC bottom plate is adhered to one side surface, far away from the nitrocellulose membrane layer, of the water absorption layer; through cooperation of the structures, the pain feeling during sampling can be reduced, and the tissue fluid collecting efficiency is improved.

The present invention provides a pharmaceutical composition for use in a method of treating pulmonary arterial hypertension (PAH). [Solution] A pharmaceutical composition for use in a method for treating pulmonary arterial hypertension (PAH) in a patient in need, comprising an ActRIIA fusion protein, wherein the ActRIIA fusion protein is (i) ActRIIA polypeptide containing a specific amino acid sequence, (ii) Fc domains containing an amino acid sequence that is at least 95% identical to a specific amino acid sequence, (iii) comprising a linker domain located between the ActRIIA polypeptide and the Fc domain, Herein, the ActRIIA fusion protein is administered in a first dose of 0.3 mg / kg and a second dose of 0.7 mg / kg, wherein the second dose is administered after confirming that the patient has an acceptable hemoglobin level and / or platelet count, in a pharmaceutical composition.

This application provides a method, system, electronic device, and storage medium for predicting wound healing progress based on 3D point cloud reconstruction, relating to the field of 3D point cloud reconstruction technology. This application generates spectral feature vectors containing biological indicators such as hemoglobin concentration and tissue oxygenation status by acquiring the reflectance spectral data and initial three-dimensional point cloud data of the wound. The initial point cloud is processed to obtain target data that retains its spatial morphology. The spectral feature values ​​are then fused point-by-point with the spatial coordinates of the target point cloud to generate a three-dimensional point cloud data cube. A 3D convolutional neural network is used to extract the spatial structural features within the cube, and the changes in spectral features at adjacent time points are tracked using optical flow, coupling the two. Based on the coupling results, a cell migration map is constructed, and the changing trend of node connection strength in the map is analyzed to obtain the predicted wound healing progress, which can improve the accuracy and comprehensiveness of wound healing progress prediction.

A method of providing personalized treatment for a diabetes patient including a remote device which is configured to receive a first data indicative of an analyte level of a subject during a first time period, retrieve a first glycated hemoglobin level for the subject associated with the first time period, calculate a first personal apparent glycation ratio for the first time period using the received first data and the retrieved first glycated hemoglobin level, compare the calculated first personal apparent glycation ratio to a representative apparent glycation ratio, generate a recommendation based on the comparison, and display a graphical interface comprising the calculated first personal apparent glycation ratio, the representative apparent glycation ratio, and the comparison.

The invention discloses a low-oxygen affinity deoxidized hemoglobin spray and application thereof. The invention creatively discovers that the oxygen concentration on the surface of a wound is obviously higher than that of pure deoxidized hemoglobin and high-oxygen-affinity deoxidized hemoglobin with higher oxygen carrying capacity after the low-oxygen-affinity deoxidized hemoglobin with higher oxygen release capacity is used; it is proved that the low-oxygen affinity deoxidized hemoglobin is more beneficial to improvement of the oxygen concentration of the wound surface. According to the specific embodiment of the invention, the RSR-13 is combined with the deoxidized hemoglobin, the conformation of the deoxidized hemoglobin is changed, the oxygen affinity of the deoxidized hemoglobin is reduced, the oxygen release of the deoxidized hemoglobin in the hypoxia tissue is effectively enhanced, the drug has no obvious toxicity to skin cells, the effectiveness and safety of the drug in skin wound treatment are improved, and the application prospect is wide. The method is suitable for treating multiple types of wound surfaces, and has wide application value and market prospect.

To provide nucleic acid molecules targeting a BCL11A enhancer functional region, compositions comprising the nucleic acid molecules, and methods for increasing a fetal hemoglobin level in cells by disrupting BCL11A expression at the genomic level.SOLUTION: Disclosed is a nucleic acid molecule comprising a nucleic acid sequence being: a. complementary to the plus or minus strand of the human chromosome 2 at location 60725424 to 60725688 (+55 functional region); b. complementary to the plus or minus strand of the human second chromosome at location 60722238 to 60722466 (+58 functional region); or c. complementary to the plus or minus strand of the human chromosome 2 at location 60718042 to 60718186 (+62 functional region), where the human chromosome 2 is that according to UCSC Genome Browser hg 19 human genome assembly.SELECTED DRAWING: Figure 3G

The invention belongs to the technical field of protein beverages, and particularly relates to a composite peptide beverage and a preparation process thereof. The active ingredients of the drink comprise calf thymosin, cattle spleen protein peptide, hemoglobin peptide, bone collagen peptide and collagen peptide in a weight ratio of (2-3): 1: 1: 1: 1. The pH value of the system is adjusted to 3.5-4.5, so that each peptide molecule is positively charged under the acidic condition, the electrostatic repulsion and hydration among molecules are enhanced, and bitter groups are effectively masked. The flavoring agent is compounded by DL-malic acid, crystalline fructose, xylitol and sucralose according to the weight ratio of (0.6-1): 1: 0.4: (0.03-0.04), and the sour and sweet taste and flavor coordination are synergistically improved. The preparation method comprises the following steps: dissolving the DL-malic acid in purified water, dissolving the uniformly mixed active components in purified water at 40-60 DEG C, respectively adding other flavoring agents, stabilizing agents and essence, and finally filtering to obtain the product. The problem of bad flavor of the peptide is solved, so that the beverage is appropriate in taste, harmonious in flavor and easy to accept.

A wearable, skin adhesive blood gas monitoring device detects both oxygen and carbon dioxide for accommodating a potential inaccuracy in an oxygen level resulting from excessive carbon dioxide. Photoluminescent films in conjunction with a compact form-factor circuit provide a wearable and unobtrusive device that adheres directly to the epidermal surface for computation of blood gas levels based on transcutaneous and reflective properties of the blood gases. A wireless medium such as Bluetooth® enables communication to a standalone or portable device such as a smartphone or similar personal device having an application (app) for receiving the computed signals. Conditions such as hypercarbia, which tend to result in higher levels of carbaminohemoglobin, or hemoglobin bound to CO2 instead of oxygen, tend to compromise computed oxygen levels by interpreting the CO2-bound hemoglobin as oxygenated blood.

To provide a blood sugar level measuring device and a blood sugar level measuring method capable of accurately calculating a blood sugar level.SOLUTION: The blood glucose level measurement device 1 includes a light output unit 3 that outputs measurement light L to a living body 6, a light detection unit 4 that detects the measurement light L transmitted through the living body 6, a time phase difference calculation unit 51 that calculates a time phase difference between an oxygenated hemoglobin waveform and a deoxygenated hemoglobin waveform based on a detection result of the light detection unit 4, a blood glucose level calculation unit 52 that calculates a blood glucose level of the living body 6 based on the calculated time phase difference, and a blood glucose level calibration unit 54 that calibrates the blood glucose level calculated by the blood glucose level calculation unit 52. The blood-sugar-level calibrating unit 54 performs calibration such that the blood sugar level calculated by the blood-sugar-level calculating unit 52 during sleep of the living body 6 or in a predetermined period after the living body 6 wakes up from sleep corresponds to a reference blood sugar level set in advance.SELECTED DRAWING: Figure 3

Light reflected from a pregnant woman's abdomen and fetus contained therein that has been received by a detector and converted into a reflected electronic signal may be received by a processor. A portion of the reflected electronic signal that is reflected from the fetus may be isolated and the isolated portion of the reflected electronic signal may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. The isolation may be achieved by synchronizing the reflected electronic signal with a fetal heartbeat signal and multiplying the synchronized reflected electronic signal by the synchronized fetal heartbeat signal.