84 results about "Vascular function" patented technology

The invention discloses a non-invasive wearable vascular arteriosclerosis assessment system and method based on multi-mode pulse wave signal fusion, and belongs to the field of vascular function assessment. The system comprises a distributed acquisition front end, a butterfly-shaped flexible substrate, an integrated double-accelerometer, a four-wavelength LED (530nm / 660nm superficial blood vessel measurement), a 810nm / 940nm deep artery measurement device, a double-photodiode, a double-impedance electrode and a pressure sensor. The central integrated control end processes a multi-mode signal and realizes pressure-LED current closed-loop control; the upper computer terminal extracts the multi-modal pulse wave time difference of the limbs and the neck, the local and regional pulse wave conduction velocity and the blood oxygen hemoglobin change parameters induced by the standardized posture, the dimension is reduced to 30 through principal component analysis, then the parameters are input into the random forest regression model, and the vascular elasticity index is output. Signal stability is improved through flexible fitting, single-source limitation is solved through multi-modal fusion, signal quality is guaranteed through closed-loop control, sensitivity is enhanced through dynamic physiological excitation, and accuracy and universality of arteriosclerosis assessment are improved.

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The invention relates to the technical field of intelligent medical treatment, and provides a blood vessel function detection method based on multi-physiological signal fusion and a related product. The method comprises the following steps: respectively acquiring arterial pulse wave signals of a first measurement part and a second measurement part of a user through a first sensor and a second sensor configured on the wearable equipment; collecting motion state data of a user in the process of collecting the arterial pulse wave signal through an inertial measurement unit configured on the wearable device, and dynamically compensating the arterial pulse wave signal based on the motion state data; extracting a characteristic waveform through a signal processing model based on the dynamically compensated arterial pulse wave signal; according to the first characteristic waveform and the second characteristic waveform after dynamic compensation, calculating the characteristic time difference of the pulse wave conducted from the first measurement part to the second measurement part; and inputting the characteristic time difference, the static physiological parameter of the user and / or at least one waveform morphological parameter into a blood vessel hardness evaluation model to obtain a blood vessel hardness evaluation value.

Methods and systems for assessing cardiovascular functions of a patient are described. The method comprises acquiring ECG data and BIA data concomitantly through a plurality of electrodes positioned in an ECG configuration, predicting parameters of cardiovascular function from the ECG data and the BIA data using deep learning algorithms, and outputting surrogates of parameters of cardiovascular functions in a clinical format.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The invention discloses an intracranial posterior circulation vascular stenosis functional evaluation method and system, electronic equipment and a computer readable storage medium, and provides a vascular stenosis functional evaluation method based on bilateral blood flow conditions by fully considering the combined action of intracranial bilateral vertebral arteries on blood flow supply. The problem that in the prior art, only one side vertebral artery is considered to conduct vascular stenosis function evaluation, and the accuracy is low is solved, if only one side of the vertebral artery on the two sides of a patient has lesion, the compensation function of the opposite side healthy vertebral artery is neglected in the prior art, the influence of lesion on vascular function can be overestimated, and the vascular stenosis function evaluation accuracy is improved. According to the method, the bilateral vertebral arteries are coupled through the pressure drop constraint condition, and the intracranial posterior circulation vascular stenosis functional evaluation is comprehensively performed in combination with the condition of the basilar artery, so that the method is more accurate, and the output evaluation dimension is wider.

The invention discloses a 3D bio-printing bone marrow mesenchymal stem cell extravascular stent as well as a preparation method and application of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent. The 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on bio-ink of bone marrow mesenchymal stem cells (BMSCs) containing SIRT3 overexpression, and the bio-ink contains methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA). The invention further discloses a preparation method of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent, and the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent has the advantages that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on the bio-ink; the effect of improving the long-term patency rate of the vein bridge is evaluated by establishing a rat artery-vein transplantation model. Experimental results show that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent not only has good structural stability and biocompatibility, but also can significantly improve the long-term patency rate of a venous bridge, promote repair of damaged tissues and enhance the vascular function recovery capability, and has potential application prospects in improving the treatment effect of cardiovascular diseases.

This invention discloses the application of MYDGF in pharmaceuticals and medical devices for treating vascular intimal hyperplasia, belonging to the field of pharmaceutical technology. This invention utilizes MYDGF as a target in the preparation of products for protecting vascular function, and applies MYDGF in the preparation of drugs for treating vascular intimal hyperplasia, drugs for metabolic disorders related to vascular intimal hyperplasia, and medical devices for treating vascular intimal hyperplasia. This invention provides new candidate drugs and protein therapies for the clinical treatment of intimal hyperplasia.

The invention provides a liver cancer capillary density evaluation system based on a CD34 and GPC-3 combined marker. The liver cancer microvessel density evaluation system based on the CD34 and GPC-3 combined marker comprises a digital pathology scanning module, a tumor area recognition module, a microvessel feature extraction module, a spatial correlation analysis module, a molecular subtype integration module, a microvessel invasion evaluation module, a prognosis prediction module, a dynamic layering module, a report generation module and a treatment recommendation module. The liver cancer microvessel density evaluation system based on the CD34 and GPC-3 combined marker has the advantages that the limitation of single quantification of microvessels is broken through, multi-dimensional accurate analysis of the liver cancer microenvironment is achieved through blood vessel function typing and spatial topology modeling, and conversion from pathological diagnosis to individualized treatment is promoted.

A method of monitoring a blood vessel, the method comprising using a system for monitoring blood vessel function, imaging a patient's body to obtain a geometry of a blood vessel; imaging a patient's body to obtain a shape of a location of the patient's body using image analysis; and analyzing vibrations of the patient's body at a location of the patient's body including the blood vessel to observe, listen to, and feel blood vessel function. A method for monitoring blood vessel function, the method comprising illuminating one or more blood vessels passing through a patient's skin; taking at least one image of the blood vessels; analyzing the at least one image; and calculating a parameter related to blood vessel function based on image analysis. Related devices and methods are also described.

The invention discloses a blood vessel parameter processing method and medical equipment, and the method comprises the steps: displaying a blood vessel function switching control which displays a plurality of blood vessel function options and statistical options; first user input or second user input is received, the first user input is used for selecting at least one of the multiple blood vessel function options, and the second user input is used for selecting the statistical option; in response to the first user input, displaying a measurement result of a blood vessel parameter corresponding to the selected blood vessel function option; and in response to the second user input, displaying a measurement result of at least one blood vessel parameter corresponding to at least two blood vessel function options in the plurality of blood vessel function options, and a statistical analysis result of at least one blood vessel parameter corresponding to the at least two blood vessel function options. According to the method and the medical equipment, great convenience is provided for multi-parameter and multi-dimensional evaluation of the vascular function of the user.

The invention provides a training method, a recognition method, a system and equipment for a fistula anomaly recognition model. The training method comprises the steps that a training data set is acquired, the training data set comprises a plurality of pieces of sample data, and each piece of sample data comprises fistula anomaly recognition influence parameters and corresponding sample anomaly recognition results; wherein the fistula abnormity identification influence parameters comprise fistula tremor signals and blood flow and / or blood vessel diameter; and training a preset model based on the plurality of sample data to obtain a fistula anomaly recognition model. According to the method, the fistula tremor signal, the blood flow and / or the blood vessel diameter and the corresponding sample anomaly recognition result are jointly used as the sample data to train the model, the accuracy of the fistula anomaly recognition model is improved, anomaly recognition can be performed on the fistula in real time, accurate evaluation about the internal arteriovenous fistula blood vessel function is provided for doctors, and the accuracy of the fistula anomaly recognition model is improved. Therefore, various complications of internal arteriovenous fistula can be timely and accurately treated, and the safety of a patient is guaranteed.

The present application relates to mosquito-like blood sampling unmanned plane technical field, especially mosquito-like blood sampling unmanned plane with infrared induction blood vessel function, including unmanned plane main part, the bottom edge of unmanned plane main part is fixedly connected with a plurality of supporting claws, the lower surface of supporting claw is fixedly provided with a hair sticking device, the bottom of unmanned plane main part is fixedly connected and is provided with a mounting bracket, the mounting bracket is rotatably connected and is provided with an adjusting bracket, the adjusting bracket below is provided with a fixing cover, the fixing cover is rotatably connected and is provided with a blood sampling seat, through setting hair combing mechanism on unmanned plane main part, the hair of blood sampling site can be combed to both sides when blood sampling is carried out, the hair of blood sampling site can be effectively removed, so that the infrared sensor simulation mosquito can more accurately perceive the temperature difference of blood vessel, help positioning blood vessel, reduce the difficulty of blood vessel positioning due to hair shielding, avoid the deviation of needle or puncture failure caused by the resistance of hair.

A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound / vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function. The analysis system can calculate additional CV function measurements from the EKG signals to augment the CV function measurements calculated from the CV signals, and predict BP measurements using the full complement of CV function measurements.

This invention discloses a nano-bandage for preserving cut flowers, belonging to the field of horticultural technology. The nano-bandage consists of a polymer carrier and a bactericide encapsulated therein. The polymer is a mixture of PEG and PDMAEMA. By adjusting the mass fraction and total concentration of PDMAEMA, the particle size of the nanoparticles can be controlled, and their surface can be positively charged. It is prepared using microfluidic co-assembly technology, where the drug-containing organic phase and aqueous phase are instantaneously mixed and purified by dialysis. This nano-bandage actively targets and persistently accumulates on the negatively charged cut surface of fresh cut flowers using electrostatic interactions, forming a physical barrier. It also synergistically inhibits microbial infection through slow-release bactericide and charge adsorption, while its nano-size does not affect vascular function. This invention achieves precise and long-lasting protection for cut flower wounds, significantly extending vase life with extremely low dosage, and has the advantages of high efficiency, safety, and intelligent adjustability.

The invention relates to the technical field of mosquito-like blood sampling unmanned aerial vehicles, in particular to a mosquito-like blood sampling unmanned aerial vehicle with a blood vessel infrared induction function, which comprises an unmanned aerial vehicle main body, a plurality of supporting claws are fixedly connected to the bottom edge of the unmanned aerial vehicle main body, and hair sticking devices are fixedly arranged on the lower surfaces of the supporting claws. A mounting frame is fixedly connected to the bottom of the unmanned aerial vehicle body, an adjusting frame is rotatably connected to the mounting frame, a fixing cover is arranged below the adjusting frame, and a blood sampling seat is rotatably connected into the fixing cover. According to the device, hair at a blood sampling part can be effectively removed, so that the infrared sensor simulates mosquitoes to more accurately sense the temperature difference of blood vessels, blood vessel positioning is facilitated, blood vessel positioning difficulty caused by hair shielding is reduced, and needle head deviation or puncture failure caused by hair resistance is avoided.

The invention provides a preparation method of a compound SS-23 and application of the compound SS-23 in preparation of drugs for preventing and / or treating atherosclerosis, and belongs to the technical field of chemical drugs. The compound SS-23 is a compound as shown in a formula I or a pharmaceutically acceptable salt thereof. The phenolic acid glyceride compound SS-23 is separated and purified from rhizoma sparganii, and the compound can play a role in preventing and / or treating atherosclerosis by adjusting the blood fat level, reducing the plaque area and improving the vascular function. The compound SS-23 has remarkable potential in the aspect of preventing and / or treating atherosclerosis, provides a new treatment strategy for clinic, and has a good application prospect. Formula I.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

The present invention relates to the technical field of pulmonary vascular function analysis methods, and specifically to a pulmonary ICG fluorescence dynamic diffusion quantitative analysis method, comprising the following steps: acquiring a patient's lung slice image; receiving fluorescent tracer injection information; constructing a three-dimensional lung model based on the lung slice image; establishing a blood vessel model and a blood flow model based on the three-dimensional lung model; simulating the fluorescent tracer diffusion process in the three-dimensional lung model and the blood vessel model according to the fluorescent tracer injection information; calculating the flow rate of all pipelines using an optical flow method; determining key time points according to preset conditions; calculating the flow value of each pipeline at the key time point of the tracing process based on the key time points; calculating the maximum flow change rate and the maximum flow difference according to the flow values; acquiring physiological parameter information corresponding to the three-dimensional lung model, and generating a vascular function evaluation model, thereby improving the accuracy of blood vessel recognition, especially significantly improving the recognition ability of tiny blood vessels.

A method for displaying data on a patient's arm, comprising the steps of taking an image of the patient's arm, analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and displaying the information by projecting a light pattern onto the patient's arm. A system for displaying data on a patient's arm, comprising a light source for illuminating the patient's arm, a sensor for taking an image of the patient's arm, a computer for analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and a projector for displaying the information by projecting a light pattern onto the patient's arm. Related apparatus and methods are also described.

Techniques are provided for analyzing data received from at least one portable physiological measuring device that is configured for temporary attachment to a human body. The techniques involve receiving, from sensors temporarily attached to peripheral artery locations of the body, vascular performance data. A portable signal measuring device determines elasticity of one or more blood vessels based on the vascular performance data. This information is input into at least one algorithm that performs an analysis that includes determining one or more changes in the one or more physiological metrics. Based on the analysis, the algorithm determines whether the one or more changes indicate an immediate physiological response or a delayed physiological response, and a severity of the one or more changes.

The invention belongs to the technical field of protein polypeptides, and particularly discloses a CD93 affinity peptide and application thereof in preparation of antitumor drugs or detection reagents. The polypeptide with a CD93 protein affinity effect is obtained through repeated screening and optimization, and an affinity blocking activity experiment proves that the CD93 affinity peptide can affine an extracellular IgV-like structural domain of the CD93 protein and block the interaction of CD93 / IGFBP7 protein. An HUVECs cell in-vitro migration experiment and a tube formation experiment verify that the CD93 affinity peptide can inhibit migration of HUVECs cells and tube formation, promote normalization of tumor vascular functions and further inhibit growth of tumors, and has no obvious toxic or side effect. The CD93 affinity peptide provided by the invention can be used for preparing anti-tumor drugs (including anti-tumor immunotherapy drugs) or detection reagents taking CD93 as a target spot, has a better medical application prospect, and provides a new choice for tumor immunotherapy.

According to the traditional Chinese medicine health-care preparation with the blood vessel dredging and multi-effect conditioning functions, 50% of traditional Chinese medicines with homology of medicine and food are combined with other traditional Chinese medicines, so that multi-effect conditioning is achieved, toxic and side effects are small, and the traditional Chinese medicine health-care preparation can be taken for a long time. According to the composition of the preparation, the traditional Chinese medicines for promoting blood circulation to remove meridian obstruction and the traditional Chinese medicines for soothing the nerves and tonifying the brain are scientifically combined together to achieve the effect of mutual enhancement. The preparation is a medicinal liquor, and is convenient to use and scientific in preparation process. The preparation has a powerful blood vessel dredging function; the traditional Chinese medicine composition also has the functions of regulating the antioxidant capacity of cells, removing excessive free radicals, prolonging the apoptosis time, recovering neuronal functions, inhibiting the growth of tumor cells, regulating immunity, supplementing activating factors and the like. The traditional Chinese medicine can be used for preventing and treating hypertension, coronary heart disease, arrhythmia (atrial and ventricular premature beat), rheumatic arthritis, bronchial asthma, malignant tumor, depression, insomnia, senile amnesia, white hair and alopecia; the goals of beautifying, health care and life prolonging are achieved.

The invention discloses an IVUS system with an FFR evaluation function and application of the IVUS system, and relates to the technical field of medical imaging. An ultrasonic transducer is arranged at the far end of the catheter and used for acquiring a blood vessel cross section image; at least two independent air pressure channels are embedded in the catheter, are respectively exposed at the near end and the far end of a blood vessel cavity and are used for sensing local blood pressure; the handle is connected with the catheter and used for driving the ultrasonic transducer to rotate and axially move; the air pressure sensor module is arranged at the connector interface of the catheter and the handle, is hermetically connected with the air pressure channel and is used for measuring the pressure in the blood vessel in real time; and the main control module is used for receiving the blood vessel cross section image and the pressure data of the air pressure sensor module, calculating an FFR value according to the pressure data of the air pressure sensor module, and performing fusion display on the FFR value and the corresponding intravascular ultrasonic image. According to the application, not only can intravascular ultrasonic structure imaging be realized, but also blood vessel function evaluation can be provided.

Systems and methods for enhanced user interface and crosstalk analysis for cardiac index determination. An example method includes accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels; obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and causing presentation of a user interface, wherein the user interface: presents a graph mapping the length to the index indicative of vascular function, presents individual toggles enabling nulling of individual lesions, and updates the graph in response to received user input to one or more of the toggles, wherein the user input nulls effects of one or more lesions.

A computer-implemented method for determining a vascular function of a perfusion imaging sequence, includes the steps of: (i) receiving a perfusion imaging sequence including a voxel time series for a plurality of voxels; (ii) applying a trained classifier on the perfusion imaging sequence for receiving voxel-wise weights; (iii) receiving voxel-wise weights from the classifier; and (iv) determining the vascular function as the weighted sum of the voxel time series; wherein the classifier is trained by optimizing over the similarity between a predicted vascular function and a ground truth vascular function using a set of examples.

A method for monitoring blood vessels, the method including using a system for monitoring blood vessel functionality to look, listen and feel blood vessel functionality by imaging a patient's body to obtain blood vessel geometry, imaging a patient body to obtain a shape of a location of the patient's body using image analysis, and analyzing vibrations of the patient's body at a location of the patient's body which includes the blood vessels. A method for monitoring blood vessel functionality, the method including illuminating one or more blood vessels through a patient's skin, capturing at least one image of the blood vessels, analyzing the at least one image, and calculating a parameter associated with blood vessel functionality based upon the image analysis. Related apparatus and methods are also described.