139 results about "Vascular function" patented technology

The present invention is related to mammalian nutrition and effects thereof in individuals with age associated cognitive decline such as Age Associated Memory Inpairment (AAMI) or a dementing illness such as Alzheimer's disease or related dementia, or Mild Cognitive Impairment, such as improving performance in, or reversal, prevention, reducing and delaying decline in, one or more of cognitive function, memory, behavior, cerebrovascular function, motor function, and / or brain physiology are seen. In particular, the present invention utilizes medium chain triglycerides, in one embodiment, administered as part of a long-term treatment regimen, to preserve or improve learning, attention, motor performance, cerebrovascular function, social behavior, and to increase activity levels, particularly in aging mammals.

The present invention relates to assessing and measuring vascular and endothelial function. A vasostimulant is provided to a patient to stimulate hemodynamic activity in a selected extremity and vascular function is assessed by monitoring a change in a blood flow, skin temperature and / or blood oxygen content at the selected extremity and assessing the patient's vascular function based upon the monitoring.

Methods and apparatus are provided for assessing the risk of an acute cardiovascular event that includes providing an endothelial or vascular function test to identify higher risk from lower risk individuals in a population of symptomatic individuals presenting with chest pain that have inconclusive results in ECG and cardiovascular marker tests, such as a tropinin test, and are administered for triage in hospital and additional tests such as ECG exercise and nuclear stress tests. The invention further provides methods and apparatus for assessing the vascular status and response of patients in clinical trials for cardiovascular therapies.

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

Embodiments of the present invention include a monitoring device and method for measuring, recording and transmitting a pre-determined set of electrocardiogram measurements. The device provides for an unassisted six or twelve channel measurements of heart and vascular functions using a visual graphical output. Results of the measurements are charted and can be reviewed and analyzed by an authorized health care provider.

The present invention relates to compositions for supplementing the diet of subjects suffering from cardiovascular or peripheral vascular disease or those at risk for such conditions. Ribose is given alone or in combination with one or a combination of vasodilators, nutrients and vitamins. Preferred vitamins include Vitamins C, B6, B12 and folic acid. Preferred nutrients include glutamine and glucose.

Dysregulation of vascular function is observed in brain endothelium derived from patients affected by Alzheimer's disease. This may be manifested at the cell or organ level: e.g., abnormal capillary morphogenesis, defective angiogenesis, inappropriate cellular senescence, mitotic catastrophe, or combinations thereof. This observation can be used for diagnosis or treatment of neurodegenerative disorders and other cognitive impairments.

The invention relates to diagnostic and therapeutic tools and applications, particularly useful in diseases that affect vascular health and in inflammatory diseases. In particular, said diagnostic and therapeutic tools employ suitable detection or modulation of endothelial glycocalyx.

The invention relates to a functional peptide-reinforced healthcare food which comprises, by weight, 2 to 5 parts of glutathione preparation material, 2 to 5 parts of sea cucumber or marine fish protein peptide preparation material, 0.04 to 0.1 part of R-lipoic acid, (1 to 3)X10-5 parts of folic acid, 0.2 to 0.5 part of procyanidins, 2 to 5 parts of food grade L-citrulline and 4 to 8 parts of excipient or filler. The invention provides a glutathione high-yield bacterial strain saccharomyces cerevisiae which can reduce production cost of glutathione and enables glutathione to be more widely applied nutriment. Glutathione serves as an important raw material, and a small molecular weight peptide with an important physiological function, citrulline and other physiological active materials with synergistic effect are matched with glutathione so as to provide the healthcare food which has the functions of enhanced antioxidation, aging resistance and cardiovascular protection.

The invention discloses a portable multifunctional monitoring and analyzing instrument for cerebral circulation dynamics. The portable multifunctional monitoring and analyzing instrument for the cerebral circulation dynamics comprises a detection unit, a data conversion unit and an analysis unit in sequence, wherein the detection unit comprises a blood flow velocity detection module, a blood pulsating pressure detection module and an electrocardiograph detection module which are arranged in parallel, signals of the three modules are output to the data conversion module and are converted into data through the data conversion unit, and the analysis unit is used for calculating cerebral circulation dynamic indexes and a total score of cerebral vascular functions according to the data output by the data conversion unit. According to the scheme, the portable multifunctional monitoring and analyzing instrument for the cerebral circulation dynamics can rapidly and comprehensively evaluate cerebral vascular function state and damage degree, has great significance in pre-warning of stroke, objective evaluation of therapeutic measures, screening of prevention and cure drugs and the like, solves the key technical problem of a data acquisition system and an analysis system, breaks monopoly of overseas technologies and clears away obstacles in large-scale application of a novel cerebrovascular disease detecting instrument.

The invention relates to a purely natural Chinese medicinal plant preparation, in particular to herbal tea for clearing liver and improving eyesight. The herbal tea improves and cures a series of physiological problems caused by fast pace of life, increment of work pressure, smoking, drinking, imbalanced diet, excessive eating and physiological function decline of organs. The herbal tea consists of the following raw materials in part by weight: 2 to 40 parts of black bean, 2 to 40 parts of Chinese magnoliavine fruit, 0.5 to 10 parts of cinnamomvine, 1 to 20 parts of chrysanthemum, 1 to 20 parts of mulberry, 1.5 to 30 parts of balsam pear, 1 to 15 parts of cassia seed, 1 to 30 parts of mulberry leaf and 1 to 20 parts of seabuckthorn leaf. The herbal tea has the effects of clearing liver, improving eyesight, promoting restoration of optic nerve function and blood vessel function, improving local blood circulation and eliminating local free radical. The herbal tea plays a role in adjusting eyesight function and hepatic and renal function, promoting health of eyesight, liver and kidney, enhancing immunologic function, improving quality of life and strengthening survival ability.

The invention relates to Tenascin-C and peptides that bind thereto. According to the invention, Tenascin-C or peptides and antibodies that bind thereto can be used to treat or prevent vascular diseases, either alone or in combination with therapeutic agents or cells that have cardioplastic potential.

The invention relates to a compound rehabilitation system. The rehabilitation system comprises a rehabilitation training bed, a lower-limb pulling muscle joint training module in the accommodating cavity and a control system, wherein the rear half part of the rehabilitation training bed is provided with an accommodating cavity; a lower limb blood circulation rehabilitation module is fixed on the lower-limb pulling muscle joint training module; and the control system comprises a microprocessor, a memory, an input module, an output module, a rotary coder, a pulling motor speed-regulation controller, an overload torque sensor, an air pressure sensor, a temperature sensor and a communication module. The compound rehabilitation system integrates joint motion, muscle extension, blood vessel function and blood circulation into a whole, is used for controlling motion of the rehabilitation system by means of the control system, and is intelligent since spontaneous determination can be carried out according to the rehabilitation training condition of a patient; and rehabilitation training condition of a patient can be carries safety and efficiency.

A method for evaluation of renal perfusion with power Doppler ultrasonography is disclosed in the present invention. Serial renal vascular images at different vascular areas including the whole vascular tree, interlobar, arcuate, and interlobular vessels were captured. Imaging processing software was designed to analyze the changes of power Doppler intensity of colored pixels within regions of interest (ROI). Power Doppler Vascularity index (PDVI) has been defined as the percentage of vascular perfusion within a region of interest (ROI). The renal vascular perfusion index (RVPI) is defined as the maximal power Doppler vascular index divided by minimal power Doppler vascular index (PDVImax / PDVImin) among the serial images. The mean of weighted power Doppler vascular index (WPDVImean) is defined as the average of the intensity of color pixels among the ROI within the serial images. By using the RVPI and WPDVImean, a more dynamic sense of vascular perfusion and a novel approach for the evaluation of renal vascular function in clinical practice can be provided.

Biomedical images of both anatomical structure and real-time changes in neuronal, metabolic, positional, and vascular function in humans and animals is described. Ultra-wideband (UWB) pulse or square wave generators and electrical samplers, implemented using integrated circuits are used to make arrays of miniaturized microwave modules that are placed around the portion of interest in the body or head, allowing images to be made through either time-domain transmission of these pulsed waves through the body, or time domain reflectivity of the waves from internal structures, or their combination. Signal processing separate and extract the time-varying functional information from the static structural image data. The time-varying functional information from certain brain regions can be interpreted in order to control prosthetics, Brain-Machine-Interfaces and the like.

A device and system for simulating normal and disease state cardiovascular functioning, including an anatomically accurate cardiac simulator for training and medical device testing. The system and device uses pneumatically pressurized chambers to generate ventricle and atrium contractions. In conjunction with the interaction of synthetic valves, which simulate mitral and aortic valves, the system is designed to generate pumping action that produces accurate volume fractions and pressure gradients of pulsatile flow, duplicating that of a human heart. Through the use of a control unit and sensors, one or more parameters, such as flow rates, fluidic pressure, and heart rate, may be automatically controlled, using feedback loop mechanisms to adjust parameters of the hydraulic system to simulate a wide variety of cardiovascular conditions including normal heart function, severely diseased or injured heart conditions, and compressed vasculature, such as hardening of the arteries.

Compositions and methods for preventing, reducing, or delaying decline in one or more of cognitive function, motor function, cerebrovascular function, or behavior in animals, particularly geriatric animals, are disclosed. The compositions and methods utilize medium chain triglycerides.

The present invention describes a device and system for simulating normal and disease state cardiovascular functioning, including an anatomically accurate left cardiac simulator for training and medical device testing. The system and device uses pneumatically pressurized chambers to generate ventricle and atrium contractions. In conjunction with the interaction of synthetic valves, which simulate mitral and aortic valves, the system is designed to generate pumping action that produces accurate volume fractions and pressure gradients of pulsatile flow, duplicating that of a human heart. Through the use of a control unit and sensors, one or more parameters, such as flow rates, fluidic pressure, and heart rate, may be automatically controlled, using feedback loop mechanisms to adjust parameters of the hydraulic system to simulate a wide variety of cardiovascular conditions including normal heart function, severely diseased or injured heart conditions, and compressed vasculature, such as hardening of the arteries.

The invention discloses pilatory and a preparation method thereof. A natural Chinese herbal recipe taking orchid and dendrobe as main components without a side effect is adopted; an ultrasonic technology is utilized for extraction; a cavitation effect, a heat effect and a mechanical effect generated by ultrasound are main basis in an extraction process; and the advantages that the extraction rate is improved, the extraction time is shortened, the low-temperature extraction is realized, the pharmaceutical ingredients are not changed, and the like are achieved. The pilatory has stronger permeability and can be infiltrated into hair roots; the special medicinal property of the pilatory is used for stimulating cell tissues on the hair roots; the functions of blood capillary of a scalp can be improved, the blood circulation of the scalp is promoted, the supply of nourishments required for the growth of hair is increased, and the growth of the hair is accelerated. The pilatory is clinically applied to almost 800 (Shanghai, Zhejiang, Jiangsu, Japan, Malaysia and Taiwan), and the effective rate is greater than or equal to 97 percent.

A method for evaluation of renal perfusion with power Doppler ultrasonography is disclosed in the present invention. Serial renal vascular images at different vascular areas including the whole vascular tree, interlobar, arcuate, and interlobular vessels were captured. Imaging processing software was designed to analyze the changes of power Doppler intensity of colored pixels within regions of interest (ROI). Power Doppler Vascularity index (PDVI) has been defined as the percentage of vascular perfusion within a region of interest (ROI). The renal vascular perfusion index (RVPI) is defined as the maximal power Doppler vascular index divided by minimal power Doppler vascular index (PDVImax / PDVImin) among the serial images. The mean of weighted power Doppler vascular index (WPDVImean) is defined as the average of the intensity of color pixels among the ROI within the serial images. By using the RVPI and WPDVImean, a more dynamic sense of vascular perfusion and a novel approach for the evaluation of renal vascular function in clinical practice can be provided.

A method and system for use in measuring the endothelial dysfunction utilizing flow mediated dilation and determining arterial health of a patient. The system includes a non-invasive blood pressure monitor, an ultrasound system and a pulse oximeter monitor that all communicate with each other to perform the flow mediated dilation. Initially, the ultrasound transducer, blood pressure cuff and pulse oximeter sensor are positioned on an arm of the patient. The blood pressure cuff is inflated to occlude an artery for an occlusion period. Following the occlusion period, the ultrasound system is automatically signaled to begin determining a parameter of the artery, such as diameter, and the flow rate of blood through the artery without any operator intervention. At the same time, the pulse wave velocity PWV is calculated between the ultrasound transducer and the finger probe of the pulse oximeter following the occlusion period. Based upon the detected characteristics of the artery before and after occlusion, as well as the PWV, the system can determine the endothelial dysfunction and arterial health of the patient.

The invention provides a parslane herb nutritive food, which belongs to the filed of foods. The parslane herb nutritive food is mainly characterized in that: parslane herb, dried crataegus pinnatifida, black fungus, orange skin, lappa, black rice, soy and other raw materials are prepared in a certain proportion; and a scientific formula is adopted; edible wild herb, mushrooms and grains are combined. After the combination of pharmaceutical and edible raw materials and the grains are combined as food, the parslane herb nutritive food has diversified nutrients that have a synergetic and complementary effect and can strengthen the stomach, disperse food, improve vascular function and immunity and improve the positive qi of human body.

The invention discloses a cardiac function assessment method for accurate selection of athletes. The method includes the following steps: 1) testing a per stroke volume SV1 and a heart rate HR1 of a tested athlete at rest, and calculating cardiac output per minute CO1 at rest according to CO being SV*HR; 2) performing a quantitative load cardiovascular exercise test on the athlete, and measuring an average anaerobic power PP; 3) immediately testing the athlete after completing the exercise in step 2), measuring a per stroke volume SV2 and a heart rate HR2 immediately after exercise, and calculating the calculating cardiac output per minute CO2 immediately after exercise; 4) calculating a cardiac index CI1 at rest and a post-exercise immediate cardiac index CI2 according to the cardiac index CI being cardiac output per minute CO / body surface area BSA; and 5) calculating a cardiac reserve index CRI: CRI being K*PP / (CI2-CI1), wherein the CRI value is positively correlated with the cardiacreserve capacity, and accordingly, making a more accurate quantitative assessment of the cardiac function level of the tested athletes.

The present invention discloses neuro-stimulation systems and methods for affecting cardiovascular function, particularly for improving heart rate variability and treating arrhythmia.

The present invention discloses stomach invigorating and blood nourishing noodles, which are prepared from the following raw materials by weight: 70-80 parts of wheat powder, 30-40 parts of coix seed, 35-45 parts of panicum miliaceum, 20-30 parts of donkey meat, 20-25 parts of kumquat, 30-40 parts of watermelon, 20-30 parts of sweet potato, 15-20 parts of hotbed leek, 8-10 parts of tender pumpkin stem, 1-2 parts of corydalis bungeana, 1-3 parts of dracocephalum moldavica l, 1-3 parts of juncus effusus, 1-2 parts of saussurea costus, 1-2 parts of a noodle additive, and a proper amount of water. According to the stomach invigorating and blood nourishing noodles, wheat powder, coix seed and panicum miliaceum are adopted as the main raw materials, wherein the coix seed has effects of spleen strengthening, dampness eliminating, heat removing, pura eliminating, rheumatism removing, intestine and stomach benefiting, dieresis and edema eliminating, and the panicum miliaceum has effects of middle warmer regulating, kidney tonifying, heat removing, detoxication, kidney qi nourishing, dantian benefiting, weakness tonifying and appetite promoting; the added ass meat has effects of qi and blood nourishing, viscera benefiting and the like; the kumquat has effects of cardiovascular function maintaining, vascular sclerosis prevention, high blood pressure prevention, and prevention of other diseases; and the tender pumpkin stem has effects of lung heat clearing, stomach regulating and collateral dredging.

The invention belongs to the field of screening Chinese medicament components, and specifically relates to a method for screening 'qi and blood circulation promotion' Chinese medicament components. The method screens out the Chinese components capable of improving the micro-vascular vasomotion amplitude in a Chinese medicament through acupuncture points by using a laser Doppler micro-vascular function tester combined with an iontophoresis apparatus, and comprises the following steps in turn: determining the acupuncture points; introducing the medicament; measuring data; and collating analysisdata. The method screens out various Chinese medicament components which have the function of improving the intracutaneous micro-vascular vasomotion amplitude of correlative channels and points, and have extensive pharmacological actions. The method is originated from the breakthrough of a channel and point essence and an acupuncture mechanism, and the technical scheme of the method is significantly different from the existing researches and techniques; the method can also be directly used for finding out whether water extracts of a Chinese medicament and a Chinese medicament formula have thefunction of promoting the qi and blood circulation in addition to screening the qi and blood circulation promotion Chinese medicament components; and the processes of screening the medicament are quick and have no wounds, and the result judgment is intuitional.

The invention relates to durian biscuits which are prepared from the following raw materials in parts by weight: 90-100 parts of wheat flour, 5-10 parts of olive oil, 15-20 parts of egg white, 0-5 parts of baking soda, 5-10 parts of honey, 26-32 parts of durians and 1-6 parts of sesame. According to the biscuits, the honey promotes cardiac and cerebral and vascular functions, has a protective effect on liver and has a certain inhibiting effect on formation of fatty liver. The durian biscuits provided by the invention can be used for enhancing the resistance, eliminating fatigue and enhancing the resistance to diseases and further has a sterilizing effect to play a role of sterilizing and disinfecting the oral cavity.

Provided are novel binding molecules of human origin, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize antigens such as native endogenous proteins associated with, e.g., immune response, autoimmune disorders, inflammatory diseases, metabolic disorders, vascular function, neurodegenerative diseases or tumors. More particularly, a human Auto-Immunosome and corresponding monoclonal antibody reservoir are provided. In addition, pharmaceutical compositions, kits and methods for use in diagnosis and therapy of are described.