155 results about "Vascular function" patented technology

A system and method for predicting cardiovascular function is presented. The method includes accessing physiological measurement data and patient data from a patient. The method also includes accessing a neural network trained to predict cardiovascular function data using the physiological measurement data and patient data.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

Systems and methods for enhanced user interface and crosstalk analysis for cardiac index determination. An example method includes accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels; obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and causing presentation of a user interface, wherein the user interface: presents a graph mapping the length to the index indicative of vascular function, presents individual toggles enabling nulling of individual lesions, and updates the graph in response to received user input to one or more of the toggles, wherein the user input nulls effects of one or more lesions.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

The invention discloses a non-invasive wearable vascular arteriosclerosis assessment system and method based on multi-mode pulse wave signal fusion, and belongs to the field of vascular function assessment. The system comprises a distributed acquisition front end, a butterfly-shaped flexible substrate, an integrated double-accelerometer, a four-wavelength LED (530nm / 660nm superficial blood vessel measurement), a 810nm / 940nm deep artery measurement device, a double-photodiode, a double-impedance electrode and a pressure sensor. The central integrated control end processes a multi-mode signal and realizes pressure-LED current closed-loop control; the upper computer terminal extracts the multi-modal pulse wave time difference of the limbs and the neck, the local and regional pulse wave conduction velocity and the blood oxygen hemoglobin change parameters induced by the standardized posture, the dimension is reduced to 30 through principal component analysis, then the parameters are input into the random forest regression model, and the vascular elasticity index is output. Signal stability is improved through flexible fitting, single-source limitation is solved through multi-modal fusion, signal quality is guaranteed through closed-loop control, sensitivity is enhanced through dynamic physiological excitation, and accuracy and universality of arteriosclerosis assessment are improved.

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

The invention belongs to the technical field of medicines, and mainly relates to application of 3 ', 4'-dihydroxy flavonol in treatment of hypertension. The invention firstly provides application of 3 ', 4'-dihydroxy flavonol or pharmaceutically acceptable salt thereof in preparation of products for preventing and / or treating hypertension. The invention also provides an application of the 3 ', 4'-dihydroxy flavonol or the pharmaceutically acceptable salt thereof in preparation of a product, and the product is used for reducing blood pressure; the blood vessel function reduction is improved; the blood vessel wall thickening is improved; the heart function reduction is improved; the 3 ', 4'-dihydroxy flavonol can improve any one or more of myocardial cell hypertrophy, and the invention further provides a product which comprises an effective dose of 3 ', 4'-dihydroxy flavonol or pharmaceutically acceptable salt thereof. The application finds that the 3 ', 4'-dihydroxy flavonol and the pharmaceutically acceptable salt thereof can be effectively used for preventing or treating hypertension, and a new way is opened up for the treatment of hypertension or hypertension-related diseases.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

The invention relates to the technical field of health care products, and provides a glycopeptide composition and related products and application thereof, and the glycopeptide composition comprises the following raw materials: wheat germs, herba epimedii, fermented bean products, flaxseeds and radix bupleuri. The glycoside peptide composition formed by combining the raw materials has a synergistic effect in the aspect of cardiovascular system protection. All the components interact with one another to jointly achieve the effects of reducing serum total cholesterol and triglyceride, improving high-density lipoprotein cholesterol, resisting oxidation, improving vascular functions and the like, and the composition has a remarkable protection effect on a cardiovascular system. Besides, the activity is enriched into the five raw materials to the maximum extent, so that the method has remarkable advantages in the aspects of production process and raw material cost reduction, and is beneficial to improving the production efficiency, ensuring the product quality and reducing the operation cost.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

Exemplary embodiments provide an optical penile blood flow measuring technology for the monitoring of neurological and vascular function of structures at surgical risk. The measuring principle is to rely on optical absorption properties of blood components for penile blood flow monitoring. Certain embodiments use different wavelengths to measure changes in hemoglobin concentrations and are particularly advantageous in continuous, autonomous monitoring with real-time feedback to surgeons for potential intervention and decision-making in a timely manner. The measurements results can be used to provide real-time feedback to surgeons operating on the patient, or for off-line analysis and evaluation. Certain embodiments can operate autonomously in the continuous measurement mode, a synchronized mode, or a triggered mode, reducing the need of highly-skilled apparatus operators, allowing automatic and real-time warning to surgeons when operating in areas while preserving the functions of critical nerves, resulting in improved clinical outcomes and reducing operation costs.

The invention relates to the technical field of intelligent medical treatment, and provides a blood vessel function detection method based on multi-physiological signal fusion and a related product. The method comprises the following steps: respectively acquiring arterial pulse wave signals of a first measurement part and a second measurement part of a user through a first sensor and a second sensor configured on the wearable equipment; collecting motion state data of a user in the process of collecting the arterial pulse wave signal through an inertial measurement unit configured on the wearable device, and dynamically compensating the arterial pulse wave signal based on the motion state data; extracting a characteristic waveform through a signal processing model based on the dynamically compensated arterial pulse wave signal; according to the first characteristic waveform and the second characteristic waveform after dynamic compensation, calculating the characteristic time difference of the pulse wave conducted from the first measurement part to the second measurement part; and inputting the characteristic time difference, the static physiological parameter of the user and / or at least one waveform morphological parameter into a blood vessel hardness evaluation model to obtain a blood vessel hardness evaluation value.

The invention relates to the technical field of medical image processing, in particular to a multilevel vascular network reconstruction and segmentation method based on drainage basin analysis, which comprises the following steps: acquiring a 3D CT (three-dimensional computed tomography angiography) scanning result; based on the 3DCTA scanning result, reconstructing a 3D blood vessel network; performing image segmentation and enhancement processing on the 3DCTA scanning result to obtain an original blood vessel center line; constructing a pressure field based on the original blood vessel center line; determining a watershed position in the blood vessel network based on the pressure field; segmenting the blood vessel network according to the watershed position; and outputting a reconstructed 3D blood vessel network and a blood vessel segmentation result, and by ingeniously combining a drainage basin analysis theory and a traditional image processing technology, considering the geometric morphology and hemodynamic characteristics of the blood vessel in the blood vessel reconstruction and segmentation process. The accuracy of reconstruction and segmentation is improved, and a new view angle is provided for vascular function evaluation.

Methods and systems for assessing cardiovascular functions of a patient are described. The method comprises acquiring ECG data and BIA data concomitantly through a plurality of electrodes positioned in an ECG configuration, predicting parameters of cardiovascular function from the ECG data and the BIA data using deep learning algorithms, and outputting surrogates of parameters of cardiovascular functions in a clinical format.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The invention discloses an intracranial posterior circulation vascular stenosis functional evaluation method and system, electronic equipment and a computer readable storage medium, and provides a vascular stenosis functional evaluation method based on bilateral blood flow conditions by fully considering the combined action of intracranial bilateral vertebral arteries on blood flow supply. The problem that in the prior art, only one side vertebral artery is considered to conduct vascular stenosis function evaluation, and the accuracy is low is solved, if only one side of the vertebral artery on the two sides of a patient has lesion, the compensation function of the opposite side healthy vertebral artery is neglected in the prior art, the influence of lesion on vascular function can be overestimated, and the vascular stenosis function evaluation accuracy is improved. According to the method, the bilateral vertebral arteries are coupled through the pressure drop constraint condition, and the intracranial posterior circulation vascular stenosis functional evaluation is comprehensively performed in combination with the condition of the basilar artery, so that the method is more accurate, and the output evaluation dimension is wider.

The invention discloses a 3D bio-printing bone marrow mesenchymal stem cell extravascular stent as well as a preparation method and application of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent. The 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on bio-ink of bone marrow mesenchymal stem cells (BMSCs) containing SIRT3 overexpression, and the bio-ink contains methacrylated hyaluronic acid (HAMA) and methacrylated gelatin (GelMA). The invention further discloses a preparation method of the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent, and the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent has the advantages that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent is obtained by performing 3D bio-printing on the bio-ink; the effect of improving the long-term patency rate of the vein bridge is evaluated by establishing a rat artery-vein transplantation model. Experimental results show that the 3D bio-printing bone marrow mesenchymal stem cell extravascular stent not only has good structural stability and biocompatibility, but also can significantly improve the long-term patency rate of a venous bridge, promote repair of damaged tissues and enhance the vascular function recovery capability, and has potential application prospects in improving the treatment effect of cardiovascular diseases.

This invention discloses the application of MYDGF in pharmaceuticals and medical devices for treating vascular intimal hyperplasia, belonging to the field of pharmaceutical technology. This invention utilizes MYDGF as a target in the preparation of products for protecting vascular function, and applies MYDGF in the preparation of drugs for treating vascular intimal hyperplasia, drugs for metabolic disorders related to vascular intimal hyperplasia, and medical devices for treating vascular intimal hyperplasia. This invention provides new candidate drugs and protein therapies for the clinical treatment of intimal hyperplasia.

The invention provides a liver cancer capillary density evaluation system based on a CD34 and GPC-3 combined marker. The liver cancer microvessel density evaluation system based on the CD34 and GPC-3 combined marker comprises a digital pathology scanning module, a tumor area recognition module, a microvessel feature extraction module, a spatial correlation analysis module, a molecular subtype integration module, a microvessel invasion evaluation module, a prognosis prediction module, a dynamic layering module, a report generation module and a treatment recommendation module. The liver cancer microvessel density evaluation system based on the CD34 and GPC-3 combined marker has the advantages that the limitation of single quantification of microvessels is broken through, multi-dimensional accurate analysis of the liver cancer microenvironment is achieved through blood vessel function typing and spatial topology modeling, and conversion from pathological diagnosis to individualized treatment is promoted.

A method of monitoring a blood vessel, the method comprising using a system for monitoring blood vessel function, imaging a patient's body to obtain a geometry of a blood vessel; imaging a patient's body to obtain a shape of a location of the patient's body using image analysis; and analyzing vibrations of the patient's body at a location of the patient's body including the blood vessel to observe, listen to, and feel blood vessel function. A method for monitoring blood vessel function, the method comprising illuminating one or more blood vessels passing through a patient's skin; taking at least one image of the blood vessels; analyzing the at least one image; and calculating a parameter related to blood vessel function based on image analysis. Related devices and methods are also described.

The systems, devices, and methods presented herein use a heart pump to obtain measurements of cardiovascular function. The heart pumps described herein can operate in parallel with and unload the heart. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as pressure or motor current, then calculate and display one or more metrics of cardiovascular function. These metrics, such as left ventricular end diastolic pressure (LVEDP), left ventricular pressure, and contractility, provide valuable information to a user regarding a patient's state of heart function and recovery.

The invention discloses a blood vessel parameter processing method and medical equipment, and the method comprises the steps: displaying a blood vessel function switching control which displays a plurality of blood vessel function options and statistical options; first user input or second user input is received, the first user input is used for selecting at least one of the multiple blood vessel function options, and the second user input is used for selecting the statistical option; in response to the first user input, displaying a measurement result of a blood vessel parameter corresponding to the selected blood vessel function option; and in response to the second user input, displaying a measurement result of at least one blood vessel parameter corresponding to at least two blood vessel function options in the plurality of blood vessel function options, and a statistical analysis result of at least one blood vessel parameter corresponding to the at least two blood vessel function options. According to the method and the medical equipment, great convenience is provided for multi-parameter and multi-dimensional evaluation of the vascular function of the user.

The invention discloses application of taurine and derivatives thereof in preparation of drugs for improving vascular functions of solid tumors. According to the invention, based on the first discovery, taurine is used for enhancing ZO-1 mediated vascular endothelium tight connection and promoting solid tumor blood vessel normalization, so that the function of transplanted tumor blood vessels of mice with hepatocellular carcinoma is improved. The taurine and the derivatives thereof can be used for preparing medicines for improving vascular functions of solid tumors such as liver cancer and melanoma or researching the vascular functions of the solid tumors such as liver cancer and melanoma.

The invention provides a training method, a recognition method, a system and equipment for a fistula anomaly recognition model. The training method comprises the steps that a training data set is acquired, the training data set comprises a plurality of pieces of sample data, and each piece of sample data comprises fistula anomaly recognition influence parameters and corresponding sample anomaly recognition results; wherein the fistula abnormity identification influence parameters comprise fistula tremor signals and blood flow and / or blood vessel diameter; and training a preset model based on the plurality of sample data to obtain a fistula anomaly recognition model. According to the method, the fistula tremor signal, the blood flow and / or the blood vessel diameter and the corresponding sample anomaly recognition result are jointly used as the sample data to train the model, the accuracy of the fistula anomaly recognition model is improved, anomaly recognition can be performed on the fistula in real time, accurate evaluation about the internal arteriovenous fistula blood vessel function is provided for doctors, and the accuracy of the fistula anomaly recognition model is improved. Therefore, various complications of internal arteriovenous fistula can be timely and accurately treated, and the safety of a patient is guaranteed.

The present application relates to mosquito-like blood sampling unmanned plane technical field, especially mosquito-like blood sampling unmanned plane with infrared induction blood vessel function, including unmanned plane main part, the bottom edge of unmanned plane main part is fixedly connected with a plurality of supporting claws, the lower surface of supporting claw is fixedly provided with a hair sticking device, the bottom of unmanned plane main part is fixedly connected and is provided with a mounting bracket, the mounting bracket is rotatably connected and is provided with an adjusting bracket, the adjusting bracket below is provided with a fixing cover, the fixing cover is rotatably connected and is provided with a blood sampling seat, through setting hair combing mechanism on unmanned plane main part, the hair of blood sampling site can be combed to both sides when blood sampling is carried out, the hair of blood sampling site can be effectively removed, so that the infrared sensor simulation mosquito can more accurately perceive the temperature difference of blood vessel, help positioning blood vessel, reduce the difficulty of blood vessel positioning due to hair shielding, avoid the deviation of needle or puncture failure caused by the resistance of hair.

A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound / vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function. The analysis system can calculate additional CV function measurements from the EKG signals to augment the CV function measurements calculated from the CV signals, and predict BP measurements using the full complement of CV function measurements.

This invention discloses a nano-bandage for preserving cut flowers, belonging to the field of horticultural technology. The nano-bandage consists of a polymer carrier and a bactericide encapsulated therein. The polymer is a mixture of PEG and PDMAEMA. By adjusting the mass fraction and total concentration of PDMAEMA, the particle size of the nanoparticles can be controlled, and their surface can be positively charged. It is prepared using microfluidic co-assembly technology, where the drug-containing organic phase and aqueous phase are instantaneously mixed and purified by dialysis. This nano-bandage actively targets and persistently accumulates on the negatively charged cut surface of fresh cut flowers using electrostatic interactions, forming a physical barrier. It also synergistically inhibits microbial infection through slow-release bactericide and charge adsorption, while its nano-size does not affect vascular function. This invention achieves precise and long-lasting protection for cut flower wounds, significantly extending vase life with extremely low dosage, and has the advantages of high efficiency, safety, and intelligent adjustability.

The invention relates to the technical field of mosquito-like blood sampling unmanned aerial vehicles, in particular to a mosquito-like blood sampling unmanned aerial vehicle with a blood vessel infrared induction function, which comprises an unmanned aerial vehicle main body, a plurality of supporting claws are fixedly connected to the bottom edge of the unmanned aerial vehicle main body, and hair sticking devices are fixedly arranged on the lower surfaces of the supporting claws. A mounting frame is fixedly connected to the bottom of the unmanned aerial vehicle body, an adjusting frame is rotatably connected to the mounting frame, a fixing cover is arranged below the adjusting frame, and a blood sampling seat is rotatably connected into the fixing cover. According to the device, hair at a blood sampling part can be effectively removed, so that the infrared sensor simulates mosquitoes to more accurately sense the temperature difference of blood vessels, blood vessel positioning is facilitated, blood vessel positioning difficulty caused by hair shielding is reduced, and needle head deviation or puncture failure caused by hair resistance is avoided.

The embodiment of the invention provides a peripheral blood vessel function index obtaining device. The peripheral blood vessel function index obtaining device is used for executing the following method: receiving blood pressure parameters of a resting state and a congestive state of a target peripheral artery blood vessel; receiving blood flow parameters of a resting state and a congestive state of the target peripheral artery blood vessel, wherein the blood flow parameters comprise blood flow or blood flow velocity; according to the blood pressure parameter of the resting state and the blood flow parameter of the resting state, a blood flow resistance reference value of the resting state is obtained; acquiring a blood flow resistance reference value of the congestive state according to the blood pressure parameter of the congestive state and the blood flow parameter of the congestive state; and obtaining the ratio of the blood flow resistance reference value in the resting state to the blood flow resistance reference value in the congestive state. By acquiring the ratio of the blood flow resistance reference value in the resting state to the blood flow resistance reference value in the congestive state, the blood supply reserve released by the blood supply network when the organ corresponding to the target peripheral artery blood vessel is converted from the resting state to the congestive state can be reflected, so that the retained blood vessel dilatation and the overall blood supply condition of the organ are evaluated.

The invention provides a preparation method of a compound SS-23 and application of the compound SS-23 in preparation of drugs for preventing and / or treating atherosclerosis, and belongs to the technical field of chemical drugs. The compound SS-23 is a compound as shown in a formula I or a pharmaceutically acceptable salt thereof. The phenolic acid glyceride compound SS-23 is separated and purified from rhizoma sparganii, and the compound can play a role in preventing and / or treating atherosclerosis by adjusting the blood fat level, reducing the plaque area and improving the vascular function. The compound SS-23 has remarkable potential in the aspect of preventing and / or treating atherosclerosis, provides a new treatment strategy for clinic, and has a good application prospect. Formula I.