58 results about "Vascular function" patented technology

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

A method for increasing or improving nitric oxide signals or levels, the method comprising: administering a composition to a subject, the composition comprising: arginine or a pharmaceutically acceptable salt, ester, or derivative thereof; and tetrahydrocurcumin and / or β-aminoisobutyric acid or a pharmaceutically acceptable salt or ester thereof. The method and the composition can be used to increase, improve, or enhance nitric oxide signals or levels, inhibit nitric oxide decomposition, and increase or enhance nitrous acid and / or cyclic guanosine monophosphate levels, and can improve fatigue resistance or enhance muscle strength, maintain or improve cardiovascular health, maintain or improve vascular function and structure, inhibit or mitigate endothelial cell damage, or mitigate insufficient blood flow.

The invention relates to the technical field of intelligent medical treatment, and provides a blood vessel function detection method based on multi-physiological signal fusion and a related product. The method comprises the following steps: respectively acquiring arterial pulse wave signals of a first measurement part and a second measurement part of a user through a first sensor and a second sensor configured on the wearable equipment; collecting motion state data of a user in the process of collecting the arterial pulse wave signal through an inertial measurement unit configured on the wearable device, and dynamically compensating the arterial pulse wave signal based on the motion state data; extracting a characteristic waveform through a signal processing model based on the dynamically compensated arterial pulse wave signal; according to the first characteristic waveform and the second characteristic waveform after dynamic compensation, calculating the characteristic time difference of the pulse wave conducted from the first measurement part to the second measurement part; and inputting the characteristic time difference, the static physiological parameter of the user and / or at least one waveform morphological parameter into a blood vessel hardness evaluation model to obtain a blood vessel hardness evaluation value.

Methods and systems for assessing cardiovascular functions of a patient are described. The method comprises acquiring ECG data and BIA data concomitantly through a plurality of electrodes positioned in an ECG configuration, predicting parameters of cardiovascular function from the ECG data and the BIA data using deep learning algorithms, and outputting surrogates of parameters of cardiovascular functions in a clinical format.

The application discloses a multifunctional antibacterial coating bone implant device based on a selective vacuum perfusion process and a preparation method thereof. The method comprises the following steps: 1) pretreating a titanium alloy base; 2) performing anodic oxidation treatment on the pretreated titanium alloy base to construct a nanotube structure on the surface of the titanium alloy base; 3) selectively coating the treated titanium alloy base with a hydrogel adhesive, then immersing the titanium alloy base in a povidone iodine mixed solution to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a bone growth promoting factor to perform vacuum perfusion, and performing post-treatment, then again performing selective coating, immersing the titanium alloy base in a solution containing a blood vessel growth promoting factor to perform vacuum perfusion, and performing post-treatment; and 4) encapsulating the obtained sample surface with an in-situ self-polymerized polydopamine layer, washing and freeze-drying. The bone implant device has antibacterial, bone growth promoting and blood vessel growth promoting functions, and can greatly improve the curative effect on bone fracture symptoms accompanied by infection.

The invention discloses an intracranial posterior circulation vascular stenosis functional evaluation method and system, electronic equipment and a computer readable storage medium, and provides a vascular stenosis functional evaluation method based on bilateral blood flow conditions by fully considering the combined action of intracranial bilateral vertebral arteries on blood flow supply. The problem that in the prior art, only one side vertebral artery is considered to conduct vascular stenosis function evaluation, and the accuracy is low is solved, if only one side of the vertebral artery on the two sides of a patient has lesion, the compensation function of the opposite side healthy vertebral artery is neglected in the prior art, the influence of lesion on vascular function can be overestimated, and the vascular stenosis function evaluation accuracy is improved. According to the method, the bilateral vertebral arteries are coupled through the pressure drop constraint condition, and the intracranial posterior circulation vascular stenosis functional evaluation is comprehensively performed in combination with the condition of the basilar artery, so that the method is more accurate, and the output evaluation dimension is wider.

A method of monitoring a blood vessel, the method comprising using a system for monitoring blood vessel function, imaging a patient's body to obtain a geometry of a blood vessel; imaging a patient's body to obtain a shape of a location of the patient's body using image analysis; and analyzing vibrations of the patient's body at a location of the patient's body including the blood vessel to observe, listen to, and feel blood vessel function. A method for monitoring blood vessel function, the method comprising illuminating one or more blood vessels passing through a patient's skin; taking at least one image of the blood vessels; analyzing the at least one image; and calculating a parameter related to blood vessel function based on image analysis. Related devices and methods are also described.

The invention discloses a blood vessel parameter processing method and medical equipment, and the method comprises the steps: displaying a blood vessel function switching control which displays a plurality of blood vessel function options and statistical options; first user input or second user input is received, the first user input is used for selecting at least one of the multiple blood vessel function options, and the second user input is used for selecting the statistical option; in response to the first user input, displaying a measurement result of a blood vessel parameter corresponding to the selected blood vessel function option; and in response to the second user input, displaying a measurement result of at least one blood vessel parameter corresponding to at least two blood vessel function options in the plurality of blood vessel function options, and a statistical analysis result of at least one blood vessel parameter corresponding to the at least two blood vessel function options. According to the method and the medical equipment, great convenience is provided for multi-parameter and multi-dimensional evaluation of the vascular function of the user.

The invention provides a training method, a recognition method, a system and equipment for a fistula anomaly recognition model. The training method comprises the steps that a training data set is acquired, the training data set comprises a plurality of pieces of sample data, and each piece of sample data comprises fistula anomaly recognition influence parameters and corresponding sample anomaly recognition results; wherein the fistula abnormity identification influence parameters comprise fistula tremor signals and blood flow and / or blood vessel diameter; and training a preset model based on the plurality of sample data to obtain a fistula anomaly recognition model. According to the method, the fistula tremor signal, the blood flow and / or the blood vessel diameter and the corresponding sample anomaly recognition result are jointly used as the sample data to train the model, the accuracy of the fistula anomaly recognition model is improved, anomaly recognition can be performed on the fistula in real time, accurate evaluation about the internal arteriovenous fistula blood vessel function is provided for doctors, and the accuracy of the fistula anomaly recognition model is improved. Therefore, various complications of internal arteriovenous fistula can be timely and accurately treated, and the safety of a patient is guaranteed.

The present application relates to mosquito-like blood sampling unmanned plane technical field, especially mosquito-like blood sampling unmanned plane with infrared induction blood vessel function, including unmanned plane main part, the bottom edge of unmanned plane main part is fixedly connected with a plurality of supporting claws, the lower surface of supporting claw is fixedly provided with a hair sticking device, the bottom of unmanned plane main part is fixedly connected and is provided with a mounting bracket, the mounting bracket is rotatably connected and is provided with an adjusting bracket, the adjusting bracket below is provided with a fixing cover, the fixing cover is rotatably connected and is provided with a blood sampling seat, through setting hair combing mechanism on unmanned plane main part, the hair of blood sampling site can be combed to both sides when blood sampling is carried out, the hair of blood sampling site can be effectively removed, so that the infrared sensor simulation mosquito can more accurately perceive the temperature difference of blood vessel, help positioning blood vessel, reduce the difficulty of blood vessel positioning due to hair shielding, avoid the deviation of needle or puncture failure caused by the resistance of hair.

A system and method for cardiovascular monitoring and reporting are disclosed. The system (CV monitoring system) includes a data analysis system and an in-ear biosensor system that preferably includes left and right earbuds. The earbuds include infrasound / vibration sensors that detect biosignals from the individual including signals associated with cardiovascular activity (CV signals). The analysis system calculates cardiovascular function measurements (CV function measurements) based upon the CV signals. The CV monitoring system uses machine learning to predict blood pressure (BP) measurements of the individual based upon the CV signals and the calculated CV function measurements. In an embodiment, the CV monitoring system includes an EKG detection system that detects EKG signals associated with heart function. The analysis system can calculate additional CV function measurements from the EKG signals to augment the CV function measurements calculated from the CV signals, and predict BP measurements using the full complement of CV function measurements.

This invention discloses a nano-bandage for preserving cut flowers, belonging to the field of horticultural technology. The nano-bandage consists of a polymer carrier and a bactericide encapsulated therein. The polymer is a mixture of PEG and PDMAEMA. By adjusting the mass fraction and total concentration of PDMAEMA, the particle size of the nanoparticles can be controlled, and their surface can be positively charged. It is prepared using microfluidic co-assembly technology, where the drug-containing organic phase and aqueous phase are instantaneously mixed and purified by dialysis. This nano-bandage actively targets and persistently accumulates on the negatively charged cut surface of fresh cut flowers using electrostatic interactions, forming a physical barrier. It also synergistically inhibits microbial infection through slow-release bactericide and charge adsorption, while its nano-size does not affect vascular function. This invention achieves precise and long-lasting protection for cut flower wounds, significantly extending vase life with extremely low dosage, and has the advantages of high efficiency, safety, and intelligent adjustability.

The invention provides a preparation method of a compound SS-23 and application of the compound SS-23 in preparation of drugs for preventing and / or treating atherosclerosis, and belongs to the technical field of chemical drugs. The compound SS-23 is a compound as shown in a formula I or a pharmaceutically acceptable salt thereof. The phenolic acid glyceride compound SS-23 is separated and purified from rhizoma sparganii, and the compound can play a role in preventing and / or treating atherosclerosis by adjusting the blood fat level, reducing the plaque area and improving the vascular function. The compound SS-23 has remarkable potential in the aspect of preventing and / or treating atherosclerosis, provides a new treatment strategy for clinic, and has a good application prospect. Formula I.

This invention relates to the field of biomedicine, specifically to the application of banana fruit extract in the preparation of anticoagulant or antithrombotic drugs. The banana fruit extract provided by this invention contains flavonoids, polyphenols, polysaccharides, hydroxyanthraquinones, triterpenoids, and other components. Flavonoids and polyphenols have been widely proven to have anti-inflammatory and antioxidant effects, which can synergistically enhance the anticoagulant effect. The high potassium content of banana fruit can indirectly improve vascular function by regulating sodium-potassium balance. The banana fruit extract provided by this invention can inhibit platelet production or promote platelet metabolism, prolong clotting time, and inhibit platelet aggregation. Its natural plant components interfere with platelet aggregation by inhibiting the production of thromboxane A2, achieving anticoagulant and antithrombotic effects. The mechanism of action of banana fruit extract differs from traditional anticoagulants such as heparin, reducing the risk of bleeding. Its natural component characteristics provide a direction for the development of novel plant-derived anticoagulant drugs.

Systems and methods for post-PCI coronary analysis. An example method includes accessing a plurality of angiographic images depicting at least one vessel of a patient's heart, the angiographic images including two or more post-percutaneous coronary intervention (post-PCI) images and one or more diagnostic images, wherein the post-PCI images depict a PCI location in which a PCI is included to revascularize a lesion, and wherein the diagnostic images depict the lesion; receiving, via a user interface presenting the post-PCI images, user input specifying positions of the PCI location in the post-PCI images; determining an index indicative of vascular function based on the angiographic images, wherein the index is derived based on a three-dimensional model of the portion of the patient's heart, and wherein individual portions of the diagnostic images depicting the lesion are masked during generation of three-dimensional model; and presenting, via the user interface, summary information associated with PCI, the summary information including at least the determined index.

A method for displaying data on a patient's arm, comprising the steps of taking an image of the patient's arm, analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and displaying the information by projecting a light pattern onto the patient's arm. A system for displaying data on a patient's arm, comprising a light source for illuminating the patient's arm, a sensor for taking an image of the patient's arm, a computer for analyzing the image to thereby obtain information about the blood vessels in the patient's arm, and a projector for displaying the information by projecting a light pattern onto the patient's arm. Related apparatus and methods are also described.

Techniques are provided for analyzing data received from at least one portable physiological measuring device that is configured for temporary attachment to a human body. The techniques involve receiving, from sensors temporarily attached to peripheral artery locations of the body, vascular performance data. A portable signal measuring device determines elasticity of one or more blood vessels based on the vascular performance data. This information is input into at least one algorithm that performs an analysis that includes determining one or more changes in the one or more physiological metrics. Based on the analysis, the algorithm determines whether the one or more changes indicate an immediate physiological response or a delayed physiological response, and a severity of the one or more changes.

The invention discloses an IVUS system with an FFR evaluation function and application of the IVUS system, and relates to the technical field of medical imaging. An ultrasonic transducer is arranged at the far end of the catheter and used for acquiring a blood vessel cross section image; at least two independent air pressure channels are embedded in the catheter, are respectively exposed at the near end and the far end of a blood vessel cavity and are used for sensing local blood pressure; the handle is connected with the catheter and used for driving the ultrasonic transducer to rotate and axially move; the air pressure sensor module is arranged at the connector interface of the catheter and the handle, is hermetically connected with the air pressure channel and is used for measuring the pressure in the blood vessel in real time; and the main control module is used for receiving the blood vessel cross section image and the pressure data of the air pressure sensor module, calculating an FFR value according to the pressure data of the air pressure sensor module, and performing fusion display on the FFR value and the corresponding intravascular ultrasonic image. According to the application, not only can intravascular ultrasonic structure imaging be realized, but also blood vessel function evaluation can be provided.

Systems and methods for enhanced user interface and crosstalk analysis for cardiac index determination. An example method includes accessing a cardiac model of a portion of a patient's heart, the portion including one or more vessels of the patient's heart, and the cardiac model indicating a plurality of lesions along a length of at least one of the vessels; obtaining, based on the cardiac model for the lesions, respective positions along the length for which the lesions are associated with index drops, wherein the index drops are with respect to an index indicative of vascular function; and causing presentation of a user interface, wherein the user interface: presents a graph mapping the length to the index indicative of vascular function, presents individual toggles enabling nulling of individual lesions, and updates the graph in response to received user input to one or more of the toggles, wherein the user input nulls effects of one or more lesions.

A method for monitoring blood vessels, the method including using a system for monitoring blood vessel functionality to look, listen and feel blood vessel functionality by imaging a patient's body to obtain blood vessel geometry, imaging a patient body to obtain a shape of a location of the patient's body using image analysis, and analyzing vibrations of the patient's body at a location of the patient's body which includes the blood vessels. A method for monitoring blood vessel functionality, the method including illuminating one or more blood vessels through a patient's skin, capturing at least one image of the blood vessels, analyzing the at least one image, and calculating a parameter associated with blood vessel functionality based upon the image analysis. Related apparatus and methods are also described.

Systems and methods for simultaneous acquisition of pulsed-wave Doppler and color Doppler for retrospective analysis of cardiovascular function are disclosed. In aspects, imaging techniques are used for acquisition of raw partly processed ultrasound data. The ultrasound data is stored in its raw form, synchronized with a simultaneously acquired physiological signal. The stored ultrasound data can then be accessed and processed according to pulsed-wave Doppler and color Doppler imaging techniques to provide both a full frame, or sequence of frames of color Doppler images and a post-acquisition pulsed-wave Doppler signal of a sample volume at one or more locations within the acquisition area using the color Doppler image. Such locations can be selected automatically or by a user, and a pulsed-wave spectrum for the selected location is displayed. As the user moves the sample volume around, the pulsed-wave spectral data is recomputed and redisplayed.

1. The name of the design product: non-invasive cardiac function detection trolley. 2. The use of the design product: medical devices for non-invasive detection of cardiac and vascular function indicators. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.

Systems and methods for PCI post-operative coronary artery analysis. One example method includes acquiring a plurality of angiographic images depicting at least one blood vessel of a patient's heart, the angiographic images including two or more percutaneous coronary intervention (PCI post-operation) images depicting a PCI site where a PCI is included to perform a blood supply reconstruction of a lesion, and one or more diagnostic images depicting at least one blood vessel of the patient's heart, the PCI post-operation images depicting the PCI site where the PCI is included to perform a blood supply reconstruction of the lesion. And wherein the diagnostic image depicts a lesion; receiving a user input specifying a PCI site in the PCI post-operation image via a user interface presenting the PCI post-operation image; determining an indicator indicative of vascular function based on the angiographic image, where the indicator is derived based on a three-dimensional model of portions of the patient's heart, and where portions of the diagnostic image depicting the lesion are masked during generation of the three-dimensional model; and presenting, via a user interface, summary information associated with the PCI, the summary information including at least the determined indicator.

The invention discloses an application of jujuboside A in preparation of an anti-atherosclerosis drug, which can significantly inhibit formation of atherosclerotic plaques, improve vascular functions and reduce blood fat level, has obvious effects, and is safe and reliable.

The invention relates to a multi-parameter analysis method integrated with arteriosclerosis assessment and a health monitoring system, and the method comprises the steps: determining a pressure oscillatory wave signal based on a cuff pressure signal through synchronously collecting the cuff pressure signal and electrocardiosignals and photoelectric volume pulse wave signals of two-side finger tips; calibrating a blood pressure analysis process of the pressure oscillatory wave signal based on a systolic pressure calibration reference determined by the photoelectric volume pulse wave signal, and determining a blood pressure value; calculating a vascular function evaluation result including the arteriosclerosis degree based on a heartbeat time sequence reference determined by the electrocardiosignal, the cuff pressure signal and the photoelectric volume pulse wave signal; performing multi-parameter correlation analysis on the blood oxygen signal and the electrocardiosignal extracted from the photoelectric volume pulse wave signal to obtain a multi-parameter analysis result; the blood pressure value, the blood vessel function evaluation result and the multi-parameter analysis result are integrated, and a comprehensive health evaluation report is generated; according to the invention, integration of multi-parameter acquisition, accurate calculation and deep analysis can be realized, and comprehensive and reliable health assessment support is provided.

An assessment method for vascular function of a dialysis patient and system thereof are provided. The assessment method measures a venous end vascular pressure of the dialysis patient, and if the venous end vascular pressure of the dialysis patient exceeds a preset pressure variation range within a preset time, blood vessels of the dialysis patient are evaluated for a presence of at least one abnormality. The assessment system includes a hemodialysis device and an output device.

The invention provides an imaging analysis method based on a tumor organoid chip, which comprises the following steps: constructing a chip containing an organoid culture unit, a vascularization co-culture unit and a drug gradient generation unit for culturing tumor organoids, constructing a blood vessel-organoid co-culture system and generating a continuous drug concentration gradient respectively; an optical, magnetic resonance and intravascular ultrasound multi-mode imaging system is adopted to collect organoid form, deep structure and vascular function images; imaging data is preprocessed, defocus blurring is solved through multi-focus fusion, and spatial correlation is achieved through noise suppression and multi-modal registration; extracting features such as organ-like area change rate and blood vessel proportion based on deep learning; and integrating imaging characteristics, tumor gene mutation and clinical data to construct a multi-dimensional matrix, and training a drug sensitivity prediction model, so that the problem that the clinical transformation value is seriously restricted due to the fact that a plurality of technical bottlenecks still exist in the current imaging analysis method for the tumor organ-like chip is solved.

The invention discloses a carotid artery and radial artery synchronous monitoring-based non-invasive blood pressure and blood vessel function evaluation device, which comprises a carotid artery sensing neckband, a radial artery sensing neckband and a blood vessel function evaluation device, the radial artery sensing wrist strap is used for being worn on the wrist to collect radial artery pulse waves; the carotid artery sensing neck strap and the radial artery sensing wrist strap are each provided with a flexible piezoresistive sensor, a microsystem unit and a wireless communication module. The microsystem unit is used for amplifying and sampling an analog signal output by the flexible piezoresistive sensor and generating a digital signal with a local timestamp; the wireless communication module is used for performing clock synchronization and data transmission between the two paths of signals; and the intelligent terminal is used for receiving the two paths of synchronized signals, executing motion artifact repair and feature extraction, and outputting a blood pressure value and a blood vessel function parameter at the same time through a lightweight machine learning model. According to the invention, high-fidelity data acquisition under daily activities is realized.

The application provides an intraoperative real-time optical coherence imaging guided laser ablation treatment system, which comprises an optical guiding module, a laser treatment module and a real-time monitoring and feedback module; high-resolution three-dimensional information and blood vessel function information obtained by the optical coherence imaging guiding module are used to accurately segment the region of a tumor site, and the power and irradiation time of a radiation laser light source are accurately controlled according to the information; meanwhile, a temperature sensor monitors the tissue temperature at any time, and the system pauses laser diagnosis and treatment when the temperature exceeds the set threshold range, so that precise laser ablation treatment is realized; the application aims to overcome the problems that the current laser ablation treatment lacks real-time and accurate segmentation of tumor regions and lacks real-time monitoring and feedback of the tissues around the tumor during the operation, so that real-time and accurate laser ablation treatment of the tumor site during the operation is realized.

The application discloses a kind of composite material based on engineering spirulina, its preparation method and application, the composite material includes hydrogel matrix and the engineering spirulina carrier dispersed in the hydrogel matrix;Wherein, the surface of spirulina is loaded with polyethyleneimine-coated Fe3O4 Nanoparticles, obtain the engineering spirulina carrier, and the engineering spirulina high expression arginine.One aspect, the present application is metabolically restructured to spirulina, so that its intracellular L-arginine content is significantly improved, L-arginine can simultaneously improve vascular function through iNOS path, and through Arg-1 path, promote macrophages to repair type M2 polarization and tissue repair, from metabolic root to intervene the core obstacle of bone defect;On the other hand, spirulina is surface modified, can effectively activate osteogenesis-related gene expression, drive new bone formation.By the double modification of L-arginine enrichment and Fe3O4 Nanoparticles loading to spirulina, obtain the composite material of synergistic regulation anti-inflammatory, pro-angiogenic and pro-osteogenic, accurately match the demand of complex pathological microenvironment of bone defect, to effectively treat bone defect, especially drug-related jaw osteonecrosis.