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479 results about "Biological process" patented technology

Biological process are the processes vital for a living organism to live, and that shape its capacities for interacting with its environment. Biological processes are made up of many chemical reactions or other events that are involved in the persistence and transformation of life forms. Metabolism and homeostasis are examples.

Apparatus and method for computer modeling type 1 diabetes

The invention encompasses novel methods for developing a computer model of type 1 diabetes in a mammal. In particular, the models can include representations of biological processes associated with a pancreatic lymph node and one or more pancreatic islets. Alternatively, the models can include representations of biological processes associated with at least two conditions selected from the group consisting of autoreactive T cell production, autoreactive T cell priming, insulitis and hyperglycemia. The invention also provides methods for developing a computer model of a non-insulin replacement treatment of type 1 diabetes. The invention also encompasses computer models of type 1 diabetes, methods of simulating type 1 diabetes and computer systems for simulating type 1 diabetes and the uses thereof.
Owner:ENTELOS INC

Expandable medical device with openings for delivery of multiple beneficial agents

InactiveUS20060122697A1Increasing effective wall thicknessAdversely impactingStentsEar treatmentDiseaseCylindroma
An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. A plurality of different beneficial agents can be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different beneficial agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different beneficial agents may also be used to address different diseases, such as restenosis and acute myocardial infarction from the same drug delivery device.
Owner:INNOVATIONAL HLDG LLC

Method for water filtration

This is a method of filtration of a liquid comprising steps of sequential filtration of said liquid through at least one deep bed medium producing at least one first filtrate followed by at least one membrane medium filtration producing at least one second filtrate, wherein said membrane medium is at least periodically within said deep bed media Many types of deep bed and membrane media can be used. The domain of using contact clarification (direct filtration) can be expanded towards greater solids concentration. Operation and backwash, is simplified, continuous filtration becomes possible. Water can be water from natural source water, process water, wastewater, aqueous or non-aqueous suspensions, emulsions, solutions. Treatment can include mechanical interception of suspended particles, chemical, physical chemical, electrochemical, and biological processes. In water and wastewater processing, control over suspended solids, BOD, COD, nitrogen and phosphorus compounds, bacteria and viruses, heavy metals, color, and other constituents can be dramatically improved as compared to conventional processes. The method can be accommodated in new and modified existing treatment systems.
Owner:KHUDENKO ENG

Multispectral therapeutic light source

ActiveUS20140288351A1High cost-effectiveHigh quantum-efficiencyElectrotherapySurgeryUltravioletPeak value
A light source apparatus including light spectrum-converting materials that emit light primarily over large portions of the 360 nm-480 nm and the 590-860 nm spectral range is provided. This apparatus provides a cooled, high-luminance, high-efficiency light source that can provide a broader spectrum of light within these spectral ranges than has been cost-practical by using many different dominant peak emission LEDs. Up to 15% of the output radiant power may be in the spectral range 350-480 nm in one embodiment of this device, unless a specific separate source and lamp operating mode is provided for the violet and UV. Control methods for light exposure dose based on monitoring and controlling reflected or backscattered light from the illuminated surface and new heat management methods are also provided. This flexible or rigid light source may be designed into a wide range of sizes or shapes that can be adjusted to fit over or around portions of the bodies of humans or animals being treated, or mounted in such a way as to provide the special spectrum light to other materials or biological processes. This new light source can be designed to provide a cost-effective therapeutic light source for photodynamic therapy, intense pulsed light, for low light level therapy, diagnostics, medical and other biological applications as well as certain non-organic applications.
Owner:JONES GARY W

Plant growth lighting device and method

InactiveUS20120218750A1Maximize plant growthMinimum wastageLight source combinationsPoint-like light sourceBeam angleGrowth plant
Embodiments described herein provide systems and methods for promoting plant growth that combine beam angle control with spectral control. In one embodiment, an optical device can be configured to emit multiple colors of light at particular wavelengths. The optical device may also be configured to generate an emission spectrum with multiple peaks. The spectrum can be selected based on stimulating biological processes of a plant.
Owner:ILLUMITEX INC

Container for carrying out and monitoring biological processes

A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such as the DNA polymerase chain reaction. Biological samples are placed in containers each comprising a reservoir and a reaction portion, wherein the reaction portion has a small volume. The small volume reaction portion permits the rapid and accurate temperature modulation. With an optically transmissible reaction portion, DNA amplification may be monitored by fluorescence during PCR.
Owner:UNIV OF UTAH RES FOUND

Implants having internal features for graft retention and load transfer between implant and vertebrae

An interbody spinal implant, such as a solid-body or composite implant, includes at least one graft contact surface as one or more of the internal surfaces of the implant. The graft contact surface, for example, having at least one ridge or groove is designed to contact and promote retention and stabilization of bone growth-inducing materials placed within the internal openings of the implant body. In addition, the ridges or grooves may influence the biological processes to promote bone healing and fusion. Also disclosed are processes of fabricating the graft contact surfaces and other surface topographies on the implant.
Owner:TITAN SPINE

Methods to screen peptide libraries using minicell display

A minicell display method has been developed which has significant advantages for screening peptide libraries for candidates that can bind and effectively modulate a particular biological process. The method, based on the small, anucleate minicell, has increased versatility in generating unique sequences to screen as well as increasing the size of the peptides to be screened. In vivo mutagenesis, at the level of protein synthesis, as well as DNA replication, increases diversification of the library to be screened and therefore substantially increases the number of potential peptides that can modulate a particular biological response or mechanism.
Owner:CHILDRENS MEDICAL CENT CORP

Container for carrying out and monitoring biological processes

A thermal cycling method and device is disclosed. The device comprises a sample chamber whose temperature can be rapidly and accurately modulated over a range of temperatures needed to carry out a number of biological procedures, such as the DNA polymerase chain reaction. Biological samples are placed in containers each comprising a reservoir and a reaction portion, wherein the reaction portion has a small volume. The small volume reaction portion permits the rapid and accurate temperature modulation. With an optically transmissible reaction portion, DNA amplification may be monitored by fluorescence during PCR.
Owner:UNIV OF UTAH RES FOUND

Multispectral therapeutic light source

A light source apparatus including light spectrum-converting materials that emit light primarily over large portions of the 360 nm-480 nm and the 590-860 nm spectral range is provided. This apparatus provides a cooled, high-luminance, high-efficiency light source that can provide a broader spectrum of light within these spectral ranges than has been cost-practical by using many different dominant peak emission LEDs. Up to 15% of the output radiant power may be in the spectral range 350-480 nm in one embodiment of this device, unless a specific separate source and lamp operating mode is provided for the violet and UV. Control methods for light exposure dose based on monitoring and controlling reflected or backscattered light from the illuminated surface and new heat management methods are also provided. This flexible or rigid light source may be designed into a wide range of sizes or shapes that can be adjusted to fit over or around portions of the bodies of humans or animals being treated, or mounted in such a way as to provide the special spectrum light to other materials or biological processes. This new light source can be designed to provide a cost-effective therapeutic light source for photodynamic therapy, intense pulsed light, for low light level therapy, diagnostics, medical and other biological applications as well as certain non-organic applications.
Owner:JONES GARY W

Combined gravity separation-filtration for conducting treatment processes in solid-liquid systems

This is a method and apparatus for combined gravity separation-filtration for conducting physical, physical-chemical, chemical, and biological processes in solid-liquid systems; including but not limited to separation of dispersed solids from liquids, separation of alkalinity from the liquid stream, chemical acid-base interactions, chemical oxidation-reduction, chemical dissolution-precipitation, physical chemical adsorption, ion exchange, mass transfer in any combinations of multiple liquid-solid-gas phases, biological oxidation-reductions, biological growth, and combinations of these processes; gravity separation steps can be conducted in rectangular horizontal unidirectional flow clarifiers, rectangular or circular radial flow clarifiers, rectangular or circular vertical flow clarifiers, lamella clarifiers, suspended sludge blanket clarifiers, fluidized bed separators, and combinations thereof, wherein the filtration step is disposed in the upper portion of the combined process or side-by-side with clarification step; filtration steps are conducted in single or multiple attachment media filters, including particulate filter media either heavier than liquid or floating; liquid filtered through the attachment media is collected by holed pipes, screens, or membranes. Reagents can be introduced before the gravity separation and / or before filtration steps. This method and apparatus can be used for municipal and industrial water purification and wastewater treatment for removal of a broad range of admixtures including BOD / COD, suspended solids, nitrogen and phosphorus, organics imparting color, salts of hardness, heavy metals, and other constituents of admixture.
Owner:KHUDENKO BORIS MIKHAIL

Tunable genetic switch for regulating gene expression

ActiveUS20100175141A1Eliminating background expressionInhibit expressionBiocideGenetic material ingredientsDiseaseBinding site
The present invention relates generally the field of genetics, in particular methods, compositions and systems for controlling the inducible expression of transgenes, while eliminating background expression of transgene expression. The present invention relates to methods of use of the compositions and systems as disclosed herein for controlling the inducible expression of transgenes while eliminating background expression of transgene expression, such as use in, for example, the in generation of transgenic animals, use in therapeutic application and use in assays. In some embodiments, the present invention relates to a system of controlled expression of RNAi molecules which target binding sites in the untranslated regions of transgene, thereby the expression of the transgene is modulated and leakiness is reduced. The compositions and methods of the present invention can be used to for therapy, prophylaxis, research and diagnostics in diseases and disorders which afflict mammalian species, generation of transgenic animals, in the study of biological processes as well as for enhance performance of agricultural crops.
Owner:TRUSTEES OF BOSTON UNIV

Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
Owner:CARDEA BIO INC

Assembly for withdrawing and filtering partial volumes of process fluid

A method for withdrawing and filtering a partial volume of a particle-containing process fluid enclosed in a container, a combination of a container enclosing a process fluid and an assembly for continuously withdrawing and filtering a partial volume of a process fluid and a cross-flow filtering device are disclosed. The method, the assembly and the filtering device can be used in connection with biological process systems, in which the removal of sand, sludge, fibers and alike from partial volumes of the process fluid is necessary before additional filtration and subsequent sample analysis.
Owner:BIO GASOL IPR APS

Integrated Multi-Zone Wastewater Treatment System And Method

A wastewater treatment system has two separate but interlinked tanks containing four different zones, namely aerobic, microaerophilic, anoxic and anaerobic, for the biological treatment of the wastewater, as well as two clarification zones and a filtration unit for separation of solids from liquid. The first tank contains the aerobic, microaerophilic and anoxic zone as well as a clarification zone, while the second dank includes the anaerobic zone, a solid-liquid separation zone and a filtration unit. The aerobic zone is an airlift reactor that contains air diffusers at the bottom of the zone to introduce air into the zone. The air bubbles mix the liquid and its content of microorganisms, and provide oxygen for the aerobic biological processes that take place in this zone. Aeration also produces circulation of liquid between the aerobic zone and its adjacent microaerophilic and anoxic zones that are located at the sides and under the aerobic zone, respectively. The aerobic zone contains suspended microorganisms of heterotrophic and autotrophic groups that grow inside the circulating liquid, known as mixed liquor. Within the volume of the aerobic zone, loose carrier material or stationary objects are disposed to support the attachment of microbial biomass and the formation of microbial biofilm.
Owner:BIOCAST SYSTEMS INC

Methods for treatment of wastewater with powdered natural lignocellulosic material

ActiveUS20070170115A1Efficiently economically decontaminateProlong total treatment processTreatment using aerobic processesWaste water treatment from animal husbandryActivated sludgeCellulose
A process for treating wastewater through the use of powdered natural ligno-cellulosic materials (PNLM) for (a) physically removing colloidal and suspended volatile solids through adsorption and enhanced floc-formation and settling during pretreatment; (b) adsorbing toxic substances and elements that interfere with biological processes, thus serving to reduce their contact with and exposure to activated sludge organisms effecting wastewater treatment functions; (c) providing fixed surfaces in activated sludge wastewater treatment bioreactors for bacteria and other organisms favoring attached growth in circumstances devoid of such surfaces; (d) reducing production of biological sludge, while also helping to maintain high treatment efficiencies; and (e) following aeration, enhancing the settling characteristics of sludge with respect both to speed of settling and the vertical profile of the settled sludge.
Owner:NUVODA LLC

Methods for treatment of wastewater with powdered natural lignocellulosic material

A process for treating wastewater through the use of powdered natural ligno-cellulosic materials (PNLM) for (a) physically removing colloidal and suspended volatile solids through adsorption and enhanced floc-formation and settling during pretreatment; (b) adsorbing toxic substances and elements that interfere with biological processes, thus serving to reduce their contact with and exposure to activated sludge organisms effecting wastewater treatment functions; (c) providing fixed surfaces in activated sludge wastewater treatment bioreactors for bacteria and other organisms favoring attached growth in circumstances devoid of such surfaces; (d) reducing production of biological sludge, while also helping to maintain high treatment efficiencies; and (e) following aeration, enhancing the settling characteristics of sludge with respect both to speed of settling and the vertical profile of the settled sludge.
Owner:NUVODA LLC

Method for preparing organic fertilizer by using plant residues as raw material

The invention relates to a method for preparing an organic fertilizer by using plant residues as a raw material. The method comprises the following steps: crushing the raw material to below 20mm, stirring and mixing the broken material with animal wastes or an inorganic fertilizer; controlling the C / N ratio of the mixed materials to be (15-35) to 1 and the pH to be 6-9; adding water, so that the moisture content in the mixed materials in the step (2) is 55-70wt%; adding a first composite microbial agent to ferment; after once fermentation, raising the temperature of windrows to above 50 DEG C; and spraying a water-dispersed second composite microbial agent to ferment for the second time. With plant residues heap corruption (composting) as a biological process for succession of a microbial community, through inoculation of exogenous complex microbial agents, efficient decomposition on agricultural wastes is facilitated; different composite microbial agents are respectively added at different composting stages; and a small amount of additives (animal wastes, urea, ammonium nitrate and the like) are added, so that the composting speed is increased, and the quality of the product organic fertilizer is really improved.
Owner:烟台中正新技术有限公司

Graphene FET devices, systems, and methods of using the same for sequencing nucleic acids

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
Owner:CARDEA BIO INC

Graphene fet devices, systems, and methods of using the same for sequencing nucleic acids

Provided herein are devices, systems, and methods of employing the same for the performance of bioinformatics analysis. The apparatuses and methods of the disclosure are directed in part to large scale graphene FET sensors, arrays, and integrated circuits employing the same for analyte measurements. The present GFET sensors, arrays, and integrated circuits may be fabricated using conventional CMOS processing techniques based on improved GFET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense GFET sensor based arrays. Improved fabrication techniques employing graphene as a reaction layer provide for rapid data acquisition from small sensors to large and dense arrays of sensors. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes, including DNA hybridization and / or sequencing reactions. Accordingly, GFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and / or binding events associated with chemical processes relating to DNA synthesis within a gated reaction chamber of the GFET based sensor.
Owner:CARDEA BIO INC

Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays

ActiveUS20120065093A1Facilitate rapid acquisition of dataImprove signal-to-noise ratioTransistorNucleotide librariesCMOSAnalyte
Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.
Owner:LIFE TECH CORP

Methods and apparatus for detecting molecular interactions using fet arrays

ActiveUS20120061733A1Facilitate rapid acquisition of dataImprove signal-to-noise ratioTransistorMicrobiological testing/measurementCMOSAnalyte
Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.
Owner:LIFE TECH CORP

Methods and Apparatus for Detecting Molecular Interactions Using FET Arrays

Methods and apparatuses relating to large scale FET arrays for analyte detection and measurement are provided. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and / or concentration changes of various analyte types in a wide variety of chemical and / or biological processes.
Owner:LIFE TECH CORP

Method, system and software arrangement for reconstructing formal descriptive models of processes from functional/modal data using suitable ontology

A method, system and software arrangement in accordance with an exemplary embodiment of the present invention are provided to extract descriptive narrative from numerical experimental data augmented with ontological controlled vocabulary. One exemplary application of such system, method and software arrangement is in organizing gene-expression time course data in terms of biological processes that may be activated and deactivated as the biological system responds to its normal or perturbed environment. The present invention may also have biological applications to drug-or-vaccine discovery, understanding behavior of a cell in an altered diseased state (e.g., cancer, neuro-degeneration or auto-immune disease, etc.), genetically modifying a natural wild-type organism, genetic-engineering, etc. Other exemplary applications may include understanding neural behavior, market behavior of a population of users interacting on the Internet, etc.
Owner:NEW YORK UNIV

Method and device for inducing biological processes by micro-organs

A method, extract, and pharmaceutical composition for inducing angiogenesis in a tissue of a mammal, and of a device for the preparation and delivery of micro-organs into a mammal, are provided.
Owner:YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD

New method for processing antibiotic wastewater

The invention relates to a method for processing antibiotic wastewater, belonging to the technical field of water processing of environmental engineering. The invention uses an up anaerobic sludge blanket-aerobic membrane bioreactor (UASB-MBR) integrated device to perform biological process on the antibiotic wastewater. Firstly, aluminum polychlorid is put in antibiotic wastewater for coagulationpreprocess; COD concentration of the wastewater is lowered by 30.8%, and turbidity is smaller than 10 NTU; then the UASB-MBR integrated device is used to further deep process to control the hydraulicretention time of the system to be 20.5 hours, COD average removal ratio can reach 86.56%, and mixed liquor suspended solid (MLSS) is 3000-4000mg / l; the effective removal ratio of the integrated device is 80-85%. Water yielding COD can reach the National Bio-pharmaceutical Industrial Wastewater Discharge Standard (GB8978-1996) after being processed by the integrated device, and the discharge standard is 300mg / l.
Owner:SHANGHAI UNIV

Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders

This invention discloses methods of using krill oil and compositions comprising krill oil to treat risk factors for metabolic, cardiovascular, and inflammatory disorders. The present invention also relates to methods of using compositions comprising krill oil to modulate biological processes selected from the group consisting of glucose metabolism, lipid biosynthesis, fatty acid metabolism, cholesterol biosynthesis, and the mitochondrial respiratory chain. The present invention further includes pharmaceutical and / or nutraceutical formulations made from krill oil, methods of making such formulations, and methods of administering them to treat risk factors for metabolic, cardiovascular, and inflammatory disorders.
Owner:AKER BIOMARINE ANTARCTIC
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