179 results about "Acropustulosis" patented technology

The invention discloses a preparation method and permeation promotion application of a high-purity sponge bone needle, and belongs to the technical field of sponge bone needles. Comprising the following steps: cutting a natural sponge into pieces, soaking in deionized water, carrying out ultrasonic oscillation, filtering, and cleaning to obtain a pretreated sponge; carrying out enzymolysis on the pretreated sponge with alkaline protease to obtain a primary zymolyte; and carrying out enzymolysis with ginger protease to obtain a secondary enzymolysis product, and carrying out vacuum freeze drying to obtain the high-purity sponge spicule. The natural sponge is subjected to enzymolysis treatment through alkaline protease and ginger protease, and the high-purity sponge spicule is obtained; wheat oligopeptide is grafted on the surface of a sponge spicule, and giant salamander skin collagen, a pomegranate seed extract, a lonicerae flos extract, a centella asiatica extract, an early celery extract, an iris tectorum extract, an oyster shell extract and calcium chloride mixed treatment materials are loaded, so that the repairing effect on skin inflammation acne is improved.

The invention discloses an application of betulinic acid 28-O-beta-D-glucoside (BA-6 for short) in preparation of a medicine for preventing and treating skin inflammation. The problems that an existing medicine for treating dermatitis is limited in curative effect, slow in effect taking, multiple in side effect, high in long-term use risk, large in individual difference, high in treatment cost, likely to cause immunoreaction and the like are solved. The invention discloses application of BA-6 in prevention and treatment of atopic dermatitis, contact dermatitis, eczema, rash, psoriasis, lupus erythematosus, papule squamous skin disease, pityriasis rosea, seborrheic dermatitis, pemphigus, celestial abscess, acne, tinea corporis, impetigo, SAPHO syndrome, hidradenitis suppurativa, dermatitis caused by drugs, lichen planus, pityriasis rubra pilaris, vitiligo, prurigo nodularis, dermatitis caused by drugs, and the like for the first time. The traditional Chinese medicine composition can be used for treating skin diseases, systemic sclerosis, hidradenitis suppurativa, granulomatous skin diseases, vitiligo, dermatomyositis, chronic skin itch and alopecia areata, and has the technical progress of obviously improving skin erythema, papule, edema, scale, moss and ulceration symptoms.

This invention provides a transdermal nanoparticle delivery system for skin anti-inflammation, comprising a protein-blue calyx methyl ether-polymer shell capsule composite structure. The protein has an affinity for the skin, blue calyx methyl ether is loaded within the protein, and the polymer layer coats the surface of the protein. The blue calyx methyl ether nanoparticle transdermal delivery system has a size of 30-80 nm, and the polymer shell thickness is 10-35 nm. The surface properties of the polymer shell can be controlled according to the required transdermal delivery depth, enabling the protein to penetrate the skin barrier and be efficiently delivered deep into the skin, where the blue calyx methyl ether is then slowly released, targeting and alleviating skin inflammation. This addresses the drawback of low therapeutic efficacy of blue calyx methyl ether in treating skin inflammation due to unsatisfactory transdermal effects.

The invention discloses an application of core proteoglycan or a coding gene thereof as a target spot in preparation of psoriasis treatment drugs, and a series of experiments prove that DCN can effectively protect mouse psoriasis-like dermatitis induced by imiquimod, improve skin scale, erythema, thickening and epidermal abnormal differentiation, enhance the barrier function of skin, improve the curative effect of psoriasis, and improve the curative effect of psoriasis. A large amount of infiltration of inflammatory cells is reduced, and a certain anti-inflammatory effect is achieved. Experimental research shows that the DCN has an obvious drug effect on a psoriasis model, is safe and efficient, has no side effect, is simple in production process and has the potential of realizing medical transformation. And the potential application value of the DCN on other various skin inflammatory diseases can be expanded.

The invention discloses a high-entropy alloy nanoparticle and application thereof. The nanoparticles are formed by specific noble metals, have multienzyme activity, and can effectively remove ROS (reactive oxygen species) at an inflammation part and remodel the free radical steady state of the inflammation part; the skin inflammation reaction can be inhibited by adjusting a JAK-STAT signal channel; skin inflammation caused by psoriasis can be relieved by down-regulating inflammatory factors IL-6, IL-17 and IL-23, and a new treatment scheme is provided for psoriasis treatment.

The invention belongs to the technical field of microorganisms, and particularly relates to an oligopeptide from lactobacillus plantarum extracellular vesicles and application of the oligopeptide. Specifically, the lactobacillus plantarum extracellular vesicles can recover the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Metabolome analysis shows that effective substances having effects on skin barrier injury comprise oligopeptide KLQ; kLQ can regulate skin barrier related gene expression in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The present disclosure provides an acne-removing and recurrence-preventing composition suitable for acne-sensitive skin and its application, belonging to the field of cosmetic technology. The present disclosure selects epigallocatechin gallate glucoside, brazilin, Hibiscus sabdariffa flower extract, Ziziphus jojoba bark extract, linseed oil unsaponifiables, and guaiac extract as active ingredients of the acne-removing and recurrence-preventing composition. The active ingredients interact with each other to quickly inhibit the growth of acne-related pathogens and regulate the skin microecology; effectively inhibit skin inflammation throughout the acne process, play a role in preventing and suppressing inflammation, effectively repair the skin barrier, reduce redness, and regulate the skin's oil balance to prevent acne recurrence; in addition, the acne-removing and recurrence-preventing composition also has the effect of removing yellowness, evens skin tone, and improves skin roughness. The acne-removing and recurrence-preventing composition is mild and non-irritating and can be used on sensitive skin, expanding the application range of the acne-removing and recurrence-preventing composition.

The invention discloses spirulina extracellular vesicle hydrogel as well as a preparation method and application thereof. The spirulina extracellular vesicle hydrogel is prepared by separating spirulina extracellular vesicles and loading the spirulina extracellular vesicles on sodium alginate / carboxymethyl chitosan hydrogel, and the method is low in cost, simple, feasible, green and safe. Skin tissue lesions caused by ultraviolet radiation can be effectively prevented and treated by externally applying the hydrogel, and the skin tissue lesions comprise abnormal epidermis thickening, collagenous fiber loss and disorder and the like; skin oxidative stress caused by ultraviolet is inhibited, and the anti-oxidation effect is achieved; the skin inflammation caused by ultraviolet is relieved by inhibiting the generation of proinflammatory factors; as a skin dressing, transdermal noninvasive administration can be realized; good biological safety is shown. The method has a wide application prospect in prevention and treatment of skin ultraviolet injury related diseases by using bioactive materials.

The invention belongs to the technical field of natural products, and provides application of fucoxanthin in preparation of oral anti-alopecia drugs. Animal experiments find that long-term high-fat diet can lead to large-piece shedding of hair accompanied by skin inflammation, and fucoxanthin has a treatment effect on high-fat diet induced mouse back hair shedding and skin inflammation, can obviously relieve high-fat diet induced subcutaneous cholesterol crystal accumulation and sebaceous gland cell hypertrophy, and has the effects of preventing and treating the high-fat diet induced mouse back hair shedding and skin inflammation and preventing and treating the high-fat diet induced mouse back hair shedding and the high-fat diet induced sebaceous gland cell hypertrophy. And skin epidermal hyperplasia and cuticle thickening induced by high fat diet can be improved. Besides, cell experiments also find that fucoxanthin intervention can reduce oleic acid infiltration of the hair follicle stem cells and reduce oleic acid induced death and apoptosis of the hair follicle stem cells, and prove that fucoxanthin has a protection effect on the hair follicle stem cells, has low toxic and side effects on cells and animals as a natural algae extract, and has a good application prospect. Good clinical application prospects are realized.

The invention discloses an application of glucopyranose sulfate galactooligosacharide in preparation of a medicine for treating atopic dermatitis. The glucopyranose galactooligosaccharide can significantly improve the skin condition of a DNCB-induced atopic dermatitis mouse model, including reducing the skin inflammatory factor level, improving the skin barrier function, and reducing the lymph node quality and the number of lymphocytes, and has no abnormal influence on blood routine. The composition has the advantages of small drug application dosage, low pharmaceutical cost, safety, no side effect, strong drug effect and the like, and has a wide application prospect.

The invention discloses a method for evaluating improvement of skin inflammation and aging based on a zebra fish model and application thereof. The method comprises the following steps: S1, establishing a blank group; s2, establishing a model group; s3, establishing a sample group; s4, performing constant-temperature incubation; s5, observing the zebrafish of the blank group, the model group and the sample group under a body type fluorescence microscope, and recording the anti-inflammatory efficiency and the anti-wrinkle efficiency of the zebrafish; and S6, evaluating the skin inflammation and aging improving effect of the sample according to an anti-inflammation and anti-aging calculation formula. The method has the advantages of low cost, short test period, high reproducibility, high visualization degree, intuitive and understandable test result and the like, and can be used for accurately grading the efficacy of the cosmetic raw materials for improving skin inflammation and aging from the whole animal level.

The invention discloses a pharmaceutical composition for treating atopic dermatitis and a preparation method and application of the pharmaceutical composition for treating atopic dermatitis. The pharmaceutical composition comprises matrix vaseline, a humectant, a moistening agent, a repairing agent and an antioxidant. Two lipid components (gamma-linolenic acid and linoleic acid) are supplemented, so that eczema-like dermatitis can be obviously relieved, skin lesion inflammatory cell infiltration is reduced, the content of fatty acid in a skin barrier is recovered, treatment of atopic dermatitis is assisted, and the treatment effect on the atopic dermatitis is remarkable; the pharmaceutical composition disclosed by the invention has the advantages of quick effect on atopic dermatitis, small toxic and side effects, good safety and good medicinal prospect.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The present disclosure relates to the use of MrgprX2 antagonists in the treatment of inflammatory conditions, for example, skin inflammatory conditions. The present invention also relates to pharmaceutical compositions comprising a MrgprX2 antagonist and a pharmaceutically acceptable carrier for topical or oral administration.

This invention relates to the field of peptide technology, and more particularly to a cyclic tetrapeptide compound, its preparation method, and its applications. The peptide compound has the structure shown in Formula I, or its stereoisomer or salt thereof: c(AA1-AA2-AA3-AA4), Formula I. The cyclic tetrapeptide compound can simultaneously inhibit the release of the inflammatory factor IL-6 and effectively scavenge reactive oxygen species DPPH, ABTS, and PTIO. It can effectively inhibit the production of reactive oxygen species, alleviate skin inflammation, and improve skin condition, showing great promise in the fields of anti-inflammatory and antioxidant applications.

The present application provides a marine alga composition with soothing and repairing effects, which combines sea fennel extract and d. capillata extract, inhibits skin inflammation, promotes expression of skin protective proteins, solves skin inflammation, and has excellent soothing and moisturizing and repairing effects, fundamentally solves a series of problems of the skin, has high and efficient effects, and has a good application prospect.

The invention belongs to the technical field of microorganisms, and particularly relates to phospholipid from extracellular vesicles of phytobacterium plantarum and application of the phospholipid. Specifically, the plant lactobacillus extracellular vesicles can restore the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Through metabolome analysis, it is found that effective substances having effects on skin barrier injury comprise phospholipid 1-palmitoyl-sn-glycerol-3-phosphorylcholine (PC, 16: 0 / 0: 0); experiments prove that PC (16: 0 / 0: 0) can regulate the expression of skin barrier related genes in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The invention provides a preparation method of a purslane extract as well as a product and application of the purslane extract, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: (1) preparing purslane powder; (2) performing ultrasonic-assisted extraction on the mixed solution, and filtering to obtain filtrate 1 and filter residues; (3) performing enzymolysis extraction, and filtering to obtain filtrate 2; (4) mixing the filtrate 1 and the filtrate 2, adding a clarifying agent, stirring, standing and filtering to obtain an extracting solution; and (5) decoloring the obtained extracting solution, carrying out rotary evaporation concentration, and freeze-drying to obtain the purslane extract. The portulaca oleracea extract obtained by the method provided by the invention is high in yield, relatively high in total flavone and total polyphenol content and extremely low in protein content, so that the portulaca oleracea extract has better anti-inflammatory and anti-allergy effects, can better relieve skin inflammation when being used in cosmetics, and achieves the anti-inflammatory, repairing and soothing effects.

Compounds of the invention, such as compounds of formula (I):where R, R1, R2, R3, R4, R5, R6, and R7 are defined herein, are useful for treating cancer, autoimmune disorders, and / or skin dermatitis, and / or methods for increasing peripheral blood counts and / or improving immune system function. Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.

The invention relates to the field of medicines, in particular to a stem cell factor composite medicine composition for treating allergic dermatitis and a preparation method thereof. The composite pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of stem cell factors, 2 to 6 parts of agilawood extract, 1 to 3 parts of forskolin and 0.1 to 0.3 part of stabilizer. The pharmaceutical composition can effectively inhibit bacteria, relieve pain and relieve itching, and can remarkably relieve itching and inflammation caused by allergic dermatitis by inhibiting release of inflammatory factors.

The application discloses a kind of self-assembly hydrogel, preparation method and application, belong to material field.The application claims to protect a kind of self-assembly hydrogel, it is formed by glycyrrhizic acid, five gallate glucose and paeonol by molecular self-assembly;Wherein, the mass ratio of glycyrrhizic acid and five gallate glucose, paeonol is (10~60) :(1~8) :(2~8).The self-assembly hydrogel provided by the application is suitable for skin, raw material is natural, biocompatibility is good, mechanical and storage stability is excellent, can release paeonol and the transdermal effect is good, three components synergistically improve atopic dermatitis and other skin inflammation, and clinical value is high.In addition, the preparation process of the self-assembly hydrogel of the application is simple, can be prepared using conventional one-pot method, easy to produce.Therefore, the self-assembly hydrogel of the application has the prospect of developing into paeonol sustained-release delivery system, paeonol transdermal sustained-release preparation or skin inflammation treatment drug.

The invention discloses a bacteriostatic and anti-inflammatory polypeptide extract and application thereof in a Yao bath. The polypeptide extract is extracted from rhizomes of Coptis chinensis (Coptis chinensis Franch.), and is obtained through extraction with a phosphate buffer solution, ultrafiltration and gel chromatography purification, and the polypeptide is as shown in SEQ ID No: 1. Experiments show that the polypeptide extract has significant bacteriostatic activity on pathogenic bacteria such as escherichia coli, shows a dose-dependent anti-inflammatory effect in an RAW264.7 cell model, can effectively inhibit NO release, and has a cell survival rate of 92% or more and excellent biological safety. The polypeptide extract is applied to a Yao bath preparation, O / W type emulsion is prepared, 10 volunteers try on the Yao bath preparation, the improvement rate on mild skin inflammation symptoms (such as red and swollen and pruritus) reaches 87%, and anaphylactic reaction is avoided. The polypeptide extract is simple in preparation process and high in activity, and has a wide application prospect in the fields of cosmetics and medicines.

The invention discloses a lactobacillus casei exosome capable of improving skin aging and a preparation method of the lactobacillus casei exosome. The lactobacillus casei is lactobacillus casei RH99, and the preservation number of the lactobacillus casei exosome is CGMCC (China General Microbiological Culture Collection Center) No.32108. The lactobacillus casei RH99 exosome prepared by the preparation method disclosed by the invention has relatively strong acid resistance, and can be orally taken to reach the intestinal tract part; according to the prepared lactobacillus casei RH99 exosome, the ROS level in H2O2 induced HaCaT cells can be reduced, the expression of collagen and elastin genes COL1A1-ELN can be activated, the expression of inflammation pathway related genes TNF-alpha and IL-6 can be reduced, and inflammation damage can be reduced; the composition can inhibit the increase of MDA content in light aging skin of mice, improve the activity of antioxidant enzymes such as SOD, GSH-PX and the like, improve the content of HYP, increase the moisture content of skin and play a role in delaying skin aging; the content of TNF-alpha, IL-6, IL-18 and IL-1beta inflammatory factors in mouse serum can be reduced; the invention has important application significance and research value in preparation of products for preventing or improving skin inflammation, oxidative damage and skin aging.

The invention provides a polianthes tuberosa corm extract and a preparation method and application thereof.The preparation method includes the steps that fresh polianthes tuberosa corm and water are mixed and then smashed, then stirring extraction is conducted at the temperature of 50-70 DEG C, supernate is collected through centrifugation and filtered, and polyhydric alcohol with the volume concentration of 30-50% is added; and the polyol is 1, 3-butanediol or glycerol. According to the tuberose corm extract disclosed by the invention, by inhibiting TNF-alpha induced cortisol excessive secretion and promoting beta-ennorphin release, the dual effects of inhibiting stress and promoting soothing are realized, and the problems of skin inflammation, sensitivity, barrier damage and the like caused by psychological emotion stress are solved.

The invention relates a pharmaceutical composition comprising from 0.001 to 2% (w / v) of propane-1,2-diol as the only anti-inflammatory agent and at least one bioadhesive polymer. The pharmaceutical composition can be used in amelioration, prevention or treatment of an inflammatory condition in a mucous membrane or skin of a subject, and / or in treatment of pain associated with such an inflammatory condition.

The present invention discloses the use of sIL-36R, DDX5, and DDX5 / sIL-36R in the preparation of drugs for inhibiting, alleviating, reducing, and / or treating atopic dermatitis and / or psoriasis. The present invention also discloses the biomarker DDX5 and / or sIL-36R and / or DDX5 / sIL-36R for psoriasis and / or atopic dermatitis and their applications. DDX5 is downregulated in keratinocytes in the skin lesions of psoriasis and / or atopic dermatitis, but the expression of DDX5 returns to normal levels after the skin lesions subside. The low expression of DDX5 leads to changes in the alternative splicing of IL-36R pre-mRNA in keratinocytes, resulting in an increase in IL-36R and a decrease in soluble sIL-36R, thereby promoting the disorder of the IL-36R signaling pathway and inducing skin inflammation; while injecting sIL-36R can effectively inhibit the IL-36R signaling pathway in atopic dermatitis mice or psoriasis mice, and inhibit the expression of cytokines in the skin lesions of atopic dermatitis or psoriasis mice to alleviate atopic dermatitis. The sIL-36R, DDX5, and DDX5 / sIL-36R can be used as targets and biomarkers for the diagnosis and treatment of inflammatory skin diseases.

The present disclosure includes methods of treating a disease or condition that produces skin inflammation and / or itch. More specifically the present disclosure relates to treating skin inflammation and itch caused by diseases or disorders of the skin such as psoriasis by administering a peptide fragment of the MARCKS protein. Peptide fragments and variants thereof as disclosed in the present disclosure are useful in such methods.

A composition contains β-glucan and is used for preventing and / or treating hormone-dependent dermatitis, skin mucositis or other skin inflammatory diseases.

The invention relates to the technical field of tissue engineering repair and regeneration, in particular to application of a human dental pulp stem cell-derived exosome in preparation of drugs, and particularly application of the human dental pulp stem cell-derived exosome in preparation of drugs, in particular to application of the human dental pulp stem cell-derived exosome in preparation of drugs for treating scytitis and psoriasis, and application of the human dental pulp stem cell-derived exosome in preparation of drugs for treating scytitis and psoriasis. A safe and effective biological intervention measure is constructed to replace a traditional treatment mode, the excessive inflammatory response of the skin is effectively inhibited, meanwhile, skin injuries are repaired, recovery of a lesion area is promoted, and a new treatment measure is provided for a patient with skin inflammation.

Disclosed herein are topical compositions comprising Centella asiatica extract and mandelic acid, wherein the compositions have a pH of less than 5, and methods of using the compositions to decrease cellular senescence in skin and treat dermatoporosis. Topical compositions comprising Centella asiatica extract and mandelic acid are effective to reduce the number of senescent cells in mammalian dermis, reduce the senescence-associated secretory phenotype (SASP), downregulate at least one SASP-associated gene, increase the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulate at least one gene associated with skin inflammation, and increase fibroblast cell turnover.