135 results about "Acropustulosis" patented technology

The invention discloses a preparation method and permeation promotion application of a high-purity sponge bone needle, and belongs to the technical field of sponge bone needles. Comprising the following steps: cutting a natural sponge into pieces, soaking in deionized water, carrying out ultrasonic oscillation, filtering, and cleaning to obtain a pretreated sponge; carrying out enzymolysis on the pretreated sponge with alkaline protease to obtain a primary zymolyte; and carrying out enzymolysis with ginger protease to obtain a secondary enzymolysis product, and carrying out vacuum freeze drying to obtain the high-purity sponge spicule. The natural sponge is subjected to enzymolysis treatment through alkaline protease and ginger protease, and the high-purity sponge spicule is obtained; wheat oligopeptide is grafted on the surface of a sponge spicule, and giant salamander skin collagen, a pomegranate seed extract, a lonicerae flos extract, a centella asiatica extract, an early celery extract, an iris tectorum extract, an oyster shell extract and calcium chloride mixed treatment materials are loaded, so that the repairing effect on skin inflammation acne is improved.

This invention provides a transdermal nanoparticle delivery system for skin anti-inflammation, comprising a protein-blue calyx methyl ether-polymer shell capsule composite structure. The protein has an affinity for the skin, blue calyx methyl ether is loaded within the protein, and the polymer layer coats the surface of the protein. The blue calyx methyl ether nanoparticle transdermal delivery system has a size of 30-80 nm, and the polymer shell thickness is 10-35 nm. The surface properties of the polymer shell can be controlled according to the required transdermal delivery depth, enabling the protein to penetrate the skin barrier and be efficiently delivered deep into the skin, where the blue calyx methyl ether is then slowly released, targeting and alleviating skin inflammation. This addresses the drawback of low therapeutic efficacy of blue calyx methyl ether in treating skin inflammation due to unsatisfactory transdermal effects.

The invention belongs to the technical field of microorganisms, and particularly relates to an oligopeptide from lactobacillus plantarum extracellular vesicles and application of the oligopeptide. Specifically, the lactobacillus plantarum extracellular vesicles can recover the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Metabolome analysis shows that effective substances having effects on skin barrier injury comprise oligopeptide KLQ; kLQ can regulate skin barrier related gene expression in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The invention discloses a method for evaluating improvement of skin inflammation and aging based on a zebra fish model and application thereof. The method comprises the following steps: S1, establishing a blank group; s2, establishing a model group; s3, establishing a sample group; s4, performing constant-temperature incubation; s5, observing the zebrafish of the blank group, the model group and the sample group under a body type fluorescence microscope, and recording the anti-inflammatory efficiency and the anti-wrinkle efficiency of the zebrafish; and S6, evaluating the skin inflammation and aging improving effect of the sample according to an anti-inflammation and anti-aging calculation formula. The method has the advantages of low cost, short test period, high reproducibility, high visualization degree, intuitive and understandable test result and the like, and can be used for accurately grading the efficacy of the cosmetic raw materials for improving skin inflammation and aging from the whole animal level.

The present invention relates to a cosmetic composition, advantageously an eco-biological cosmetic composition, comprising: - polyglutamic acid or a salt thereof; and - at least one peptide derivative represented by the general formula (I) in which: - R1 represents a hydrogen atom, an acyl radical or an acyloxy radical; and - R2 represents the side chain of an alpha-amino acid chosen from the group consisting of phenylalanine, glutamic acid, arginine, cysteine, methionine, histidine and tyrosine. The present invention also relates to the use of said cosmetic composition for combating skin redness and / or skin aging; to its use for preventing and / or combating cutaneous vascular hyperproliferation and / or cutaneous inflammation and / or rosacea; and to a method for selecting compounds suitable for preventing and / or combating these pathologies.

The present disclosure relates to the use of MrgprX2 antagonists in the treatment of inflammatory conditions, for example, skin inflammatory conditions. The present invention also relates to pharmaceutical compositions comprising a MrgprX2 antagonist and a pharmaceutically acceptable carrier for topical or oral administration.

This invention relates to the field of peptide technology, and more particularly to a cyclic tetrapeptide compound, its preparation method, and its applications. The peptide compound has the structure shown in Formula I, or its stereoisomer or salt thereof: c(AA1-AA2-AA3-AA4), Formula I. The cyclic tetrapeptide compound can simultaneously inhibit the release of the inflammatory factor IL-6 and effectively scavenge reactive oxygen species DPPH, ABTS, and PTIO. It can effectively inhibit the production of reactive oxygen species, alleviate skin inflammation, and improve skin condition, showing great promise in the fields of anti-inflammatory and antioxidant applications.

The present application provides a marine alga composition with soothing and repairing effects, which combines sea fennel extract and d. capillata extract, inhibits skin inflammation, promotes expression of skin protective proteins, solves skin inflammation, and has excellent soothing and moisturizing and repairing effects, fundamentally solves a series of problems of the skin, has high and efficient effects, and has a good application prospect.

The invention belongs to the technical field of microorganisms, and particularly relates to phospholipid from extracellular vesicles of phytobacterium plantarum and application of the phospholipid. Specifically, the plant lactobacillus extracellular vesicles can restore the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Through metabolome analysis, it is found that effective substances having effects on skin barrier injury comprise phospholipid 1-palmitoyl-sn-glycerol-3-phosphorylcholine (PC, 16: 0 / 0: 0); experiments prove that PC (16: 0 / 0: 0) can regulate the expression of skin barrier related genes in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The invention provides a preparation method of a purslane extract as well as a product and application of the purslane extract, and belongs to the technical field of cosmetics. The preparation method comprises the following steps: (1) preparing purslane powder; (2) performing ultrasonic-assisted extraction on the mixed solution, and filtering to obtain filtrate 1 and filter residues; (3) performing enzymolysis extraction, and filtering to obtain filtrate 2; (4) mixing the filtrate 1 and the filtrate 2, adding a clarifying agent, stirring, standing and filtering to obtain an extracting solution; and (5) decoloring the obtained extracting solution, carrying out rotary evaporation concentration, and freeze-drying to obtain the purslane extract. The portulaca oleracea extract obtained by the method provided by the invention is high in yield, relatively high in total flavone and total polyphenol content and extremely low in protein content, so that the portulaca oleracea extract has better anti-inflammatory and anti-allergy effects, can better relieve skin inflammation when being used in cosmetics, and achieves the anti-inflammatory, repairing and soothing effects.

The invention relates to the field of medicines, in particular to a stem cell factor composite medicine composition for treating allergic dermatitis and a preparation method thereof. The composite pharmaceutical composition is prepared from the following raw materials in parts by weight: 5 to 10 parts of stem cell factors, 2 to 6 parts of agilawood extract, 1 to 3 parts of forskolin and 0.1 to 0.3 part of stabilizer. The pharmaceutical composition can effectively inhibit bacteria, relieve pain and relieve itching, and can remarkably relieve itching and inflammation caused by allergic dermatitis by inhibiting release of inflammatory factors.

The application discloses a kind of self-assembly hydrogel, preparation method and application, belong to material field.The application claims to protect a kind of self-assembly hydrogel, it is formed by glycyrrhizic acid, five gallate glucose and paeonol by molecular self-assembly;Wherein, the mass ratio of glycyrrhizic acid and five gallate glucose, paeonol is (10~60) :(1~8) :(2~8).The self-assembly hydrogel provided by the application is suitable for skin, raw material is natural, biocompatibility is good, mechanical and storage stability is excellent, can release paeonol and the transdermal effect is good, three components synergistically improve atopic dermatitis and other skin inflammation, and clinical value is high.In addition, the preparation process of the self-assembly hydrogel of the application is simple, can be prepared using conventional one-pot method, easy to produce.Therefore, the self-assembly hydrogel of the application has the prospect of developing into paeonol sustained-release delivery system, paeonol transdermal sustained-release preparation or skin inflammation treatment drug.

The invention discloses a bacteriostatic and anti-inflammatory polypeptide extract and application thereof in a Yao bath. The polypeptide extract is extracted from rhizomes of Coptis chinensis (Coptis chinensis Franch.), and is obtained through extraction with a phosphate buffer solution, ultrafiltration and gel chromatography purification, and the polypeptide is as shown in SEQ ID No: 1. Experiments show that the polypeptide extract has significant bacteriostatic activity on pathogenic bacteria such as escherichia coli, shows a dose-dependent anti-inflammatory effect in an RAW264.7 cell model, can effectively inhibit NO release, and has a cell survival rate of 92% or more and excellent biological safety. The polypeptide extract is applied to a Yao bath preparation, O / W type emulsion is prepared, 10 volunteers try on the Yao bath preparation, the improvement rate on mild skin inflammation symptoms (such as red and swollen and pruritus) reaches 87%, and anaphylactic reaction is avoided. The polypeptide extract is simple in preparation process and high in activity, and has a wide application prospect in the fields of cosmetics and medicines.

The invention discloses a lactobacillus casei exosome capable of improving skin aging and a preparation method of the lactobacillus casei exosome. The lactobacillus casei is lactobacillus casei RH99, and the preservation number of the lactobacillus casei exosome is CGMCC (China General Microbiological Culture Collection Center) No.32108. The lactobacillus casei RH99 exosome prepared by the preparation method disclosed by the invention has relatively strong acid resistance, and can be orally taken to reach the intestinal tract part; according to the prepared lactobacillus casei RH99 exosome, the ROS level in H2O2 induced HaCaT cells can be reduced, the expression of collagen and elastin genes COL1A1-ELN can be activated, the expression of inflammation pathway related genes TNF-alpha and IL-6 can be reduced, and inflammation damage can be reduced; the composition can inhibit the increase of MDA content in light aging skin of mice, improve the activity of antioxidant enzymes such as SOD, GSH-PX and the like, improve the content of HYP, increase the moisture content of skin and play a role in delaying skin aging; the content of TNF-alpha, IL-6, IL-18 and IL-1beta inflammatory factors in mouse serum can be reduced; the invention has important application significance and research value in preparation of products for preventing or improving skin inflammation, oxidative damage and skin aging.

The invention provides a polianthes tuberosa corm extract and a preparation method and application thereof.The preparation method includes the steps that fresh polianthes tuberosa corm and water are mixed and then smashed, then stirring extraction is conducted at the temperature of 50-70 DEG C, supernate is collected through centrifugation and filtered, and polyhydric alcohol with the volume concentration of 30-50% is added; and the polyol is 1, 3-butanediol or glycerol. According to the tuberose corm extract disclosed by the invention, by inhibiting TNF-alpha induced cortisol excessive secretion and promoting beta-ennorphin release, the dual effects of inhibiting stress and promoting soothing are realized, and the problems of skin inflammation, sensitivity, barrier damage and the like caused by psychological emotion stress are solved.

The invention relates a pharmaceutical composition comprising from 0.001 to 2% (w / v) of propane-1,2-diol as the only anti-inflammatory agent and at least one bioadhesive polymer. The pharmaceutical composition can be used in amelioration, prevention or treatment of an inflammatory condition in a mucous membrane or skin of a subject, and / or in treatment of pain associated with such an inflammatory condition.

Disclosed herein are topical compositions comprising Centella asiatica extract and mandelic acid, wherein the compositions have a pH of less than 5, and methods of using the compositions to decrease cellular senescence in skin and treat dermatoporosis. Topical compositions comprising Centella asiatica extract and mandelic acid are effective to reduce the number of senescent cells in mammalian dermis, reduce the senescence-associated secretory phenotype (SASP), downregulate at least one SASP-associated gene, increase the expression of at least one cell cycle-related gene in dermal fibroblasts, downregulate at least one gene associated with skin inflammation, and increase fibroblast cell turnover.

The application relates to a stoma base plate which is characterized in that the stoma base plate comprises a fitting layer, the middle of the fitting layer is provided with a through hole matched with the size of a stoma, the inner surface of the fitting layer is provided with textures, and the rigidity of the fitting layer is distributed in a gradient decreasing mode from the edge of the stoma to the peripheral direction; the rigidity of the contact part of the fitting layer and the concave area on the skin surface is lower than that of the adjacent flat area around the fitting layer, and the rigidity of the edge of the fitting layer is higher than that of the adjacent flat area around the fitting layer; and a buffer layer having a porous structure. According to the application, through the collaborative design of the stiffness gradient of the fitting layer, softening of the local concave area and edge hardening, the fitting layer can accurately adapt to the unique abdomen curved surface and skin microtopography of a patient, when the patient breathes and moves, dynamic deformation matching can be achieved through the design, the problem of excrement leakage caused by static non-fitting and dynamic gaps is solved, and the application range is widened. Complications such as skin inflammation, infection and the like caused by the traditional Chinese medicine composition are fundamentally prevented.

The invention relates to a skincare composition containing a Kakadu plum extract and a preparation method of the skincare composition. The skincare composition containing the Kakadu plum extract comprises the Kakadu plum extract, a centella asiatica extract, betaine, a humectant, a thickening agent, a chelating agent, a preservative, a solubilizer, essence, citric acid, sodium citrate and pure water. The Kakadu plum extract, the centella asiatica extract and the betaine are added into the skin care product to form the skin care composition, the advantages of the Kakadu plum extract, the centella asiatica extract and the betaine are fully played through selection of effective components and reasonable matching of the use amounts of the components, and the Kakadu plum extract, the centella asiatica extract and the betaine supplement each other to achieve a synergistic effect, so that skin inflammation can be effectively relieved, and the skin care effect is improved. Uncomfortable symptoms such as redness and swelling and pruritus are relieved, so that the occurrence of acnes is reduced, the effect of soothing the skin is achieved, and the skin is helped to recover a healthy state.

The invention discloses a composition for improving skin inflammation as well as application and a production method of the composition. The composition is prepared from the following components in parts by weight: 2 to 6 parts of curcumin monocarbonyl analogue cyclodextrin inclusion compound and 0.3 to 0.5 part of allantoin. The curcumin monocarbonyl analogue cyclodextrin inclusion compound is prepared from the following components in parts by weight: 0.5 to 1.5 parts of curcumin monocarbonyl analogue and 98.5 to 99.5 parts of beta-cyclodextrin, and the composition is applied as a skin care product. Aiming at skin inflammation caused by chronic symptoms, NF-kappa B nuclear translocation is blocked, multi-target anti-inflammation is achieved, and the effect is better directly aiming at core pathogenic genes. The allantoin increases the dissolution and absorption of the curcumin monocarbonyl analogue cyclodextrin inclusion compound, promotes the hydration of cuticle and reduces the irritation to the skin; the use effect is milder, and the composition is more suitable for non-invasive dermatitis.

This invention belongs to the field of biomedical technology, specifically relating to the application of SMOC2 protein in the preparation of psoriasis treatment drugs. The amino acid sequence of the SMOC2 protein is shown in SEQ ID NO.1. This invention has discovered that SMOC2 protein can treat psoriasis, and therefore provides the application of SMOC2 protein in the preparation of psoriasis treatment drugs. Using SMOC2 protein can treat or improve the scaling, erythema, and thickening phenotypes of the skin, as well as inhibit the abnormal proliferation of keratinocytes and the expression of inflammatory factors IL1β, IL23, cAMP, TNFα, CXCL2, CXCL3, S100A8, and S100A9. By inhibiting the infiltration of neutrophils in inflammatory cells in psoriatic lesions, it exerts a therapeutic or alleviating effect on inflammatory skin diseases.

The invention belongs to the technical field of microorganisms, and particularly relates to an oligopeptide from extracellular vesicles of phytobacterium plantarum and application of the oligopeptide. Specifically, the plant lactobacillus extracellular vesicles can restore the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Metabolome analysis shows that effective substances having effects on skin barrier injury comprise oligopeptide RFV; the RFV can regulate the expression of skin barrier related genes in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The invention provides a construction method of an atopic dermatitis animal model, and the construction method comprises the step of carrying out sensitization treatment on a TSLP transgenic mouse by adopting local skin stimulation and a mixed sensitization source so as to construct the atopic dermatitis animal model. In the technical scheme, the TSLP transgenic mouse is induced and sensitized by adopting local skin stimulation and a mixed sensitization source, and the skin of the mouse specifically expresses the TSLP, so that the skin inflammation can quickly appear and is similar to the human AD symptom. Compared with a common mouse-induced allergy animal model, the method has the advantages of high sensitization efficiency, obvious sensitization effect and the like, can be applied to experimental research on AD diseases, and provides a research model for clinical research on AD diseases.

The present invention relates to a cell penetrating peptide for delivering growth factors FGF and SCF, and a cosmetic composition thereof for wound healing, dermatitis prevention and treatment, and skin barrier formation. According to the present invention, a cell-penetrating peptide in which a carrier-transmitting peptide (CDP) is bonded to FGF or SCF according to the present invention enables a growth factor to effectively penetrate the skin or cells, thereby ensuring further convenience while improving the intrinsic efficacy of the growth factor in vivo as much as possible. The composition not only has excellent effects on wound healing, skin barrier formation, dermatitis improvement and transdermal delivery of growth factors, but also is very suitable for related industries, i.e., pharmacy, especially in the field of cosmetics.

The invention relates to application of cembratrienediol in preparation of a medicine for preventing and treating rosacea, and belongs to the technical field of biological medicine. The invention provides an application of cembratrienediol in preparation of a medicine for preventing / or treating rosacea. The cembratrienediol can obviously improve erythema and inflammation of an injection area of a rosacea mouse model for a long time and a short time; the skin tissue pathological inflammation of the rosacea mouse model can be obviously relieved (including the thickening of the skin epidermis of the rosacea mouse model, the inflammatory cell infiltration of the skin tissue of the rosacea mouse model and the capillary hyperplasia of the skin tissue of the rosacea mouse model); skin inflammation of a rosacea patient can be remarkably relieved (including relieving pain of the skin of the rosacea patient and relieving the red and swollen degree of the skin of the rosacea patient), and skin injuries of the rosacea patient can be remarkably improved (including improving papules and pustules of the skin of the rosacea patient).

The invention discloses application of an Aldicanol compound in preparation of a medicine for treating chronic skin inflammation, and belongs to the technical field of medicines. In order to solve the problem that a method for effectively treating chronic scytitis lacks in the prior art, the invention provides an application of an Aldicanol compound in preparation of a medicine for treating chronic scytitis, the Aldicanol compound is extracted from dryopteris fragrans glandular hair, and the Aldicanol compound has the effects of remarkably improving skin erythema caused by chronic scytitis, reducing scales, improving the curative effect of chronic scytitis, improving the curative effect of chronic scytitis and the like. The spleen index is reduced; the skin epidermis thickness caused by chronic skin inflammation is obviously reduced, inflammatory cell infiltration is reduced, and hair follicle inflammation is obviously weakened; proinflammatory factors can be effectively inhibited, and expression of anti-inflammatory factors can be effectively promoted; the Aldicanol compound can be applied to the treatment of chronic skin inflammation.

A method for reducing the appearance of fine lines or wrinkles, treating skin inflammation, or reducing the appearance of reddened or erythemic skin is disclosed. The method can include applying to skin having a fine line or wrinkle, having inflammation, or having a reddened or erythymic appearance a composition that includes tetrahexyldecyl ascorbate and Acmella oleracea extract, wherein application of the composition to the skin reduces the appearance of the fine line or wrinkle, treats skin inflammation, or reduces the appearance of the reddened or erythemic skin.

The invention relates to application of pholidota chinensis exosome-like nano-vesicles in preparation of a product with a skin care function, and belongs to the technical field of plant biology. The pholidota chinensis exosome-like nano-vesicle is rich in bioactive substances, has excellent biocompatibility and transmembrane delivery potential due to the bimolecular phospholipid layer structure, and has various skin care effects. Tests show that the compound has no toxicity to RBL-2H3 and RAW264.7 cells within the concentration of 6.25-100 [mu] g / mL, has remarkable proliferation promoting capacity to HaCaT cells within the concentration of 50-100 [mu] g / mL, and meets the safety requirements of cosmetics. In addition, the vesicles can effectively remove ABTS < + > and DPPH free radicals, the inhibiting capacity of the vesicles on DPPH is remarkably higher than that of aqueous extracts and close to that of VC, and the vesicles show an excellent antioxidant effect. Meanwhile, NO generation can be remarkably inhibited, and the effect of resisting skin inflammation is achieved.

The invention belongs to the technical field of biology, and particularly relates to application of DPP4 in treatment or diagnosis of inflammatory skin diseases characterized by skin barrier injury. According to the application disclosed by the invention, key effects of dipeptidyl peptidase-4 (DPP4) in regulating and controlling keratinocyte differentiation and maintaining normal skin barrier structures and functions are analyzed, and on the basis of AAV-mediated skin tissue keratinocyte DPP4 gene therapy, the conditions of abnormal epidermis thickening and abnormal differentiation caused by skin damage can be relieved by inducing normal differentiation of keratinocytes, so that the curative effect of the skin tissue keratinocyte DPP4 is improved, and the curative effect of the skin tissue keratinocyte DPP4 is improved. The traditional Chinese medicine composition provided by the invention can be used for promoting the repair of an epidermal barrier and improving and maintaining the steady state of the skin barrier so as to effectively improve psoriasis-like dermatitis, and a new scheme is provided for treating inflammatory dermatosis characterized by skin barrier injury. In addition, the expression level of DPP4 can be used as a diagnostic marker for inflammatory skin diseases characterized by skin barrier injury.

The invention discloses an anti-inflammatory and anti-aging face cream and a preparation method thereof, and belongs to the technical field of cosmetics. The face cream disclosed by the invention is prepared from the following components in percentage by weight: 5.0 to 20.0 percent of broccoli fermentation filtrate, 0.05 to 0.2 percent of andrographolide encapsulated by nano-liposome, 0.5 to 5.0 percent of a skin barrier repairing agent and a matrix. Sulforaphane (greater than or equal to 400 mg / kg) in broccoli is enriched through a lactic acid bacteria fermentation technology, and the stability and the smell of the broccoli are improved; the problem that andrographolide is difficult to dissolve and easy to crystallize is solved through embedding of nano-liposome (the particle size is 40-80 nm, and the encapsulation efficiency is larger than or equal to 85%), and the transdermal property of andrographolide is improved. The two are combined to synergistically activate an Nrf2 antioxidant pathway and inhibit an NF-kappa B inflammation pathway, and the two pathways intervene in inflammatory aging. Human body tests show that after the face cream is used for 4 weeks, the depth of wrinkles can be remarkably reduced (28.6%), the level of skin inflammatory factors TNF-alpha can be reduced (50.4%), and the face cream is free of any irritating reaction, has an excellent anti-aging effect and extremely high safety and is particularly suitable for sensitive skin.