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1300 results about "Cell model" patented technology
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Method for calculating power capability of battery packs using advanced cell model predictive techniques
ActiveUS20050110498A1Batteries circuit arrangementsMaterial analysis by electric/magnetic meansPower capabilityElectrical battery
The present invention relates to a method and an apparatus for estimating discharge and charge power of battery applications, including battery packs used in Hybrid Electric Vehicles (HEV) and Electric Vehicles (EV). One charge / discharge power estimating method incorporates voltage, state-of-charge (SOC), power, and current design constraints and works for a user-specified prediction time horizon Δt. At least two cell models are used in calculating maximum charge / discharge power based on voltage limits. The first is a simple cell model that uses a Taylor-series expansion to linearize the equation involved. The second is a more complex and accurate model that models cell dynamics in discrete-time state-space form. The cell model can incorporate a inputs such as temperature, resistance, capacity, etc. One advantage of using model-based approach is that the same model may be used in both Kalman-filtering to produce the SOC and the estimation of maximum charge / discharge current based on voltage limits.
Owner:LG ENERGY SOLUTION LTD
Method for calculating power capability of battery packs using advanced cell model predictive techniques
ActiveUS7321220B2Batteries circuit arrangementsMaterial analysis by electric/magnetic meansPower capabilityEngineering
The present invention relates to a method and an apparatus for estimating discharge and charge power of battery applications, including battery packs used in Hybrid Electric Vehicles (HEV) and Electric Vehicles (EV). One charge / discharge power estimating method incorporates voltage, state-of-charge (SOC), power, and current design constraints and works for a user-specified prediction time horizon Δt. At least two cell models are used in calculating maximum charge / discharge power based on voltage limits. The first is a simple cell model that uses a Taylor-series expansion to linearize the equation involved. The second is a more complex and accurate model that models cell dynamics in discrete-time state-space form. The cell model can incorporate a inputs such as temperature, resistance, capacity, etc. One advantage of using model-based approach is that the same model may be used in both Kalman-filtering to produce the SOC and the estimation of maximum charge / discharge current based on voltage limits.
Owner:LG ENERGY SOLUTION LTD
Delay and energy consumption-based efficient offloading method for computing task of mobile edge computing system
The invention discloses a delay and energy consumption-based efficient offloading method for a computing task of a mobile edge computing system. The method comprises the steps of building a macro basestation with multiple users and one deployment mobile edge computing (MEC) server and a single-cell cell model of a small base station without an MEC server; then building a mathematical model basedon a wireless communication theory; and finally, designing a delay and energy consumption-based efficient offloading solution for a computing task of the MEC system through a parallel greedy algorithm, and analyzing and providing the performance of the solution. Compared with existing efficient energy consumption offloading solution, the method well weights the delay sensitive demand and energy consumption demand of a terminal user, and lowers delay and total energy consumption of the system.
Owner:BEIJING UNIV OF TECH
Multi-scale multiphysics coupling simulation method of metal additive manufacturing
ActiveCN107368642AOptimizing manufacturing process parametersImprove manufacturing efficiencyDesign optimisation/simulationSpecial data processing applicationsManufacturing technologyFirst principle
The invention provides a multi-scale multiphysics coupling simulation method of metal additive manufacturing. The method comprises the following steps: S1, establishing a metal additive manufacturing technology data model; S2, carrying out first-principles calculation by calculation software on a microscale through first principles to acquire micro physical properties of additive metal material; S3, establishing an NxNxN super-cell model of the additive metal material, and carrying out molecular dynamics simulation calculation through molecular dynamics simulation software; S4, studying plasma, which is generated in a melting process of metal powder heated by an electron beam or a laser, on a mesoscale; S5, utilizing a flow-heat-solid-magnet multiphysics coupling simulation platform for simulation calculation; and S6, establishing a technology parameter feedback control model for different types and distribution situations of defects, and optimizing metal additive manufacturing technology parameters. The method forms a macro-micro-integration metal additive manufacturing product quality prediction system by means of multi-scale multiphysics coupling simulation.
Owner:湖南珞佳智能科技有限公司
Method for estimating charge state of power cell
InactiveCN102608542AIn line with the actual useReduce estimation errorElectrical testingDiscretizationData system
The invention discloses a method for estimating the charge state of a power cell, which comprises the following steps that: 1. a continuous state space model capable of expressing the relationship of each element in an expression circuit is obtained by an equivalent circuit model of a power cell; the relationship between the open-circuit voltage and the cell charge state is obtained through the standing experiment of the power cell, and the cell charge state is introduced into the continuous state space model of the power cell as a state variable; the power battery model under the noise environment is obtained by combining the noise information; and finally the continuous state space model is subjected to linearization and discretization so as to obtain a linear discrete state space model; 2. a relationship curve of the open-circuit voltage and the cell charge state is obtained through the standing experiment of the power cell, and a parameter k and a parameter d in the power cell model are obtained approximately; 3. parameters of the power cell model are obtained through the identification of current and voltage data collected by a data collecting system; and 4. the power cell charge state is estimated by utilizing a moving horizon estimation method based on the determined power cell model.
Owner:JILIN UNIV
Method for constructing chromosome translocation stem cell and animal model by CRISPR-Cas9 technology
The invention relates to a method for preparing a chromosome translocation stem cell model and an animal model. The method mainly comprises the steps of inducing occurrence of specific site chromosome translocation in stem cells by means of CRISPR / Cas9 technology, preparing a cell model and further constructing an animal model carrying the specific site chromosome translocation by utilizing embryonic stem cell technology. The method particularly comprises the steps of simultaneously introducing Cas9 and gRNA aiming at two target chromosome sites into the stem cells to artificially inducing chromosome dislocation of specific sites, and screening to obtain the cell model carrying the chromosome translocation. The animal model carrying chromosome translation of the specific sites can be further prepared from the chromosome translocation animal embryonic stem cells carrying chromosome translation by utilizing a chimera technology. The method has relatively large application prospect in studies on chromosome translocation and functions of fusion genes, researches on chromosome interaction and medicine screening evaluation.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Power-cell SOC online closed-loop estimation method based on N-2RC model
The invention discloses a power-cell SOC online closed-loop estimation method based on an N-2RC model. In the invention, an electrochemical model and an equivalent circuit model are combined and a novel power cell model is provided. The N-2RC model uses a Nernst electrochemical model to replace an electromotive force portion of a second-order RC equivalent circuit model so that one to one correspondence of a cell electromotive force and SOC can be accurately reflected. Based on the model, a recursive least-square method based on a forgetting factor is used to identify a model parameter, and then an expansion Kalman filtering algorithm is used to realize on-line closed loop estimation of the cell SOC. The electrochemical model can well describe a cell characteristic on an electrochemical aspect, but the structure is complex and the model is not suitable for individually individual usage. And the equivalent circuit model belongs to an external characteristic model and can well express a volt-ampere characteristic relationship of the cell, but can not reflect an internal characteristic of the cell. By using the method in the invention, the above problems are overcome.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Complex braided structure ceramic matrix composite fatigue retardation behavior prediction method
InactiveCN105701312AFatigue Hysteresis Behavior PredictionDesign optimisation/simulationSpecial data processing applicationsStress–strain curveMaterials science
The invention discloses a complex braided structure ceramic matrix composite fatigue retardation behavior prediction method. The method comprises the steps of calculating a fatigue stress-strain curve under circulation with a microscale model to obtain the unit constitutive relation, substituting the unit constitutive relation into a unit cell model to conduct corresponding stiffness reduction on the unit cell model under different boundary conditions, and conducting statistics on the average stress and average strain of the unit cell model to obtain a unit cell scale fatigue retardation loop under the cycle number. By means of the multiscale model, the micro stress-strain field of a complex braided structure can be given, and therefore the fatigue retardation behavior of the material can be predicted precisely.
Owner:NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
Method for knocking out two mir-505 alleles
InactiveCN104651401AVector-based foreign material introductionDNA/RNA fragmentationFluorescenceScreening method
The invention relates to a method for knocking out two mir-505 alleles. The method comprises the following steps: constructing two targeting vectors for mir-505 alleles, replacing and knocking one mir-505 allele out of a cell of a mammal by mediating one targeting vector by using a CRISPR / Cas system, obtaining the cell with one mir-505 allele being knocked out by adopting a G418 resistance screening method, knocking another mir-505 allele out of the cell of the mammal by mediating another green fluorescent targeting vector by using the CRISPR / Cas system based on the cells, and obtaining the cell with two mir-505 alleles being knocked out by adopting a fluorescence screening method. The method is helpful to constructing a gene knocked-out cell model and has good application prospect.
Owner:DONGHUA UNIV
Application of CRISPR-Cas9 system based on new gRNA (guide ribonucleic acid) sequence in preparing drugs for treating hepatitis B
PendingCN105647922AInhibition of replicationInhibit expressionOrganic active ingredientsVectorsHepatitis B virusHbv replication
The invention discloses a gRNA (guide ribonucleic acid) sequence. The sequence can be used for DNA (deoxyribonucleic acid) sequence edition by using a hepatitis B virus genome S gene conserved region site as a target sequence, can successfully destroy the HBV (hepatitis B virus) cccDNA and integrated-state HBV DNA in a HBV stable cell model and an HBV hydrodynamic mouse model, and obtains obvious effects on inhibiting HBV replication and expression. The invention also discloses application of the CRISPR-Cas9 system containing the gRNA sequence in preparing drugs for treating hepatitis B.
Owner:INST OF PLA FOR DISEASE CONTROL & PREVENTION
State and parameter estimation for an electrochemical cell
Owner:LG ENERGY SOLUTION LTD
CRISPR/Cas9 system and application thereof in construction of swine-derived recombinant cells with insulin receptor substrate gene defects
ActiveCN112522255AImprove editing efficiencyFast degradationStable introduction of DNAVector-based foreign material introductionPancreatic hormoneDiabetic animal
The invention discloses a CRISPR (clustered regularly interspaced short palindromic repeats) / Cas9 system and application thereof to construction of swine-derived recombinant cells with insulin receptor substrate gene defects. The invention provides an sgRNA (ribonucleic acid) combination which is composed of sgRNAIRS1-1, sgRNAIRS1-3, sgRNAIRS2-2 and sgRNAIRS2-3. The invention provides a plasmid combination. The plasmid combination is composed of four plasmids, and the four plasmids are respectively subjected to transcription to obtain sgRNAIRS1-1, sgRNAIRS1-3, sgRNAIRS2-2 and sgRNAIRS2-3. Theapplication of the sgRNA combination or the plasmid combination is as follows: preparation of recombinant cells; preparation of a diabetic cell model; preparation of a diabetic animal model. Accordingto the invention, sgRNAIRS1-1 is as shown in SEQ ID NO:8; sgRNAIRS1-3 is as shown in SEQ ID NO:10; sgRNAIRS2-2 is shown as SEQ ID NO:14; and sgRNAIRS2-3 is as shown in SEQ ID NO:15. A solid foundation is laid for the preparation of diabetic pig models, and important application value for the research and development of diabetic medicaments is achieved.
Owner:NANJING KGENE GENETIC ENG CO LTD
Method for dynamically dividing sector based on airspace traffic characteristics
ActiveCN103226899AUniform loadAccurate and comprehensive descriptionSpecial data processing applicationsAircraft traffic controlTraffic characteristicDivision algorithm
The invention belongs to the field of air traffic management, and discloses a method for dynamically dividing a sector based on airspace traffic characteristics, which aims to confirm a sector division matched with airspace traffic changes according to airspace traffic change control, so as to realize optimal utilization of airspace resources. The method comprises three aspects, namely airspace information extraction, airspace modeling and sector optimized division algorithm. First, databases such as an airspace topological structure are constructed on basis of airspace static structural information and airspace dynamic information; then, a complicated network model is used for describing an airspace structure through regarding key points as nodes and air routes as sides; third, similarity of associated nodes in the complicated network model is calculated according to airspace dynamic information, a complicated weighing network is established, and an airspace convex cell model is established by utilizing the K-Means algorithm based on the complicated weighing network; and finally, the airspace convex cell model is combined with the hybrid coding genetic algorithm to obtain the final sector division result.
Owner:嘉善创越知识产权服务有限公司
In-vitro evaluation cell model of skin sensitization of compound and construction method of cell model
ActiveCN108103098AEffective resolutionSensitization Study SpecificHydrolasesDrug screeningSkin sensitizationLuciferase Gene
The invention discloses an in-vitro evaluation cell model of skin sensitization of a compound and a construction method of the cell model. The construction method of the cell model comprises the following steps of: designing and constructing an sgRNA (small guide ribonucleic acid) expression vector with CRISPR / Cas9 (clustered regularly interspaced short palindromic repeats / CRISPR associated protein 9), designing and constructing a homologous recombinant vector capable of knocking a reporter gene connected with a spontaneous lysis peptide sequence into an expression cassette of an HMOX1 (heme oxygenase (decycling) 1) gene, and cotransfecting a cell with the homologous recombinant vector, hCas9 (humanized Cas9) plasmid and the sgRNA expression vector for monoclone enlarging culture to form the cell model. The HaCaT cell model with a luciferase gene knocked in before a termination codon of the HMOX1 gene by a combined CRISPR / CAS9 cell monoclone technology. The cell model achieves synchronous expression of the luciferase gene and the HMOX1 gene, so that a sensitization compound and a non-sensitization compound are effectively differentiated, and the more specific and sensitive cell model is provided for compound sensitization studies.
Owner:SOUTH CHINA UNIV OF TECH
Construction method of cell model for detecting pyrogens, cell model and pyrogen detection kit
ActiveCN106148286AImprove stabilityIncreased sensitivityCell receptors/surface-antigens/surface-determinantsCulture processWestern blotCytokine
The invention provides a construction method of a cell model for detecting pyrogens, the cell model and a pyrogen detection kit. The cell model utilizes specific locations of CRISPR / CAS9 induced genomes to form double-bond fission, TLR4 and CD14-MD2 are knocked into two chromosomes of a cell line respectively by the aid of the homologous recombination repair principle, green fluorescence GFP and red fluorescence RFP are respectively used for tracing finally successfully constructed TLR4 / CD14 / MD2 fixed-point knocked-in fluorescent tracer cell models, and the LPS stimulating cell model can detect release of IL-6 and TNF-a cytokines by means of ELISA, Western Blot, mass spectrum and immunomagnetic beads. The cell model is good in stability and high in sensitivity, and the lowest detectable limit can reach 0.005EU / mL and is far lower than 0.025EU / mL of the Tachypleus Amebocyte Lysate method.
Owner:牛刚
Cell model obtained after targeted knockout of rabbit bone morphogenetic protein-2 (BMP2) gene based on CRISPR/Cas9 and application thereof
InactiveCN106047803AEasy to prepareLow costBone-inducing factorOsteogenic factorMorphogenesisMesenchymal stem cell
The invention relates to a cell model obtained after targeted knockout of a rabbit BMP2 gene based on CRISPR / Cas9 and application thereof, belonging to the technical field of molecular biology and biomedicine. According to the invention corresponding oligos are synthesized for three targeting sites of the rabbit BMP2 gene on the design principles of CRISPR / Cas9 and are constructed on px458 vectors; and a CRISPR / Cas9 system is constructed directed at the three targeting sites in rabbit mesenchymal stem cells, and the CRISPR / Cas9 system can effectively knock out the rabbit BMP2 gene, is easy to operate and has high rabbit BMP2 gene knockout efficiency. The cell model disclosed in the invention can greatly promote research related to the functions and signaling pathways of the BMP2 gene.
Owner:QINGDAO JIAOZHOU CENT HOSPITAL
Method of calculating voltage and power of large-scaled photovoltaic power plant
InactiveUS20160224702A1Accurate estimateData processing applicationsDesign optimisation/simulationEngineeringPhotovoltaic power station
A method of calculating voltage and power of large-scaled photovoltaic power plant includes following steps. Environment models of varies locations within the photovoltaic power plant are obtained. A photovoltaic display model is established by establishing a photovoltaic cell model, combining the photovoltaic cell model with the environment models, determining a combination of the environmental data on photovoltaic panels and the photovoltaic cell model, and determining a quantitative relationship between a photovoltaic cell power generation state and photovoltaic environment. An inverter model is obtained by modeling inverters connected to photovoltaic cells. A grid-side model is obtained. An electrical energy and voltage forecast model is constructed by integrated the photovoltaic display model, the inverter model, and the grid-side model. An energy output and a voltage quality of the photovoltaic power plant is calculated by detecting voltage and current of the electrical energy and voltage forecast model.
Owner:STATE GRID CORP OF CHINA +2
LS-SVM power cell SOC estimation method and system
ActiveCN105116343AFast operationCompensate for cumulative errorElectrical testingPower batteryAlgorithm
The invention provides an LS-SVM (Least squares support vector machine) power cell SOC (State of Charge) estimation method and system, comprising the steps of: I, obtaining a Uoc based on a power cell model and parameters through an FFRLS (Forgetting factor least squares algorithm); II, fitting a Uoc-SOC relation through the FFRLS; III, building an on-line LS-SVM SOC training model; IV, estimating an SOC initial value, and estimating an SOC through an Ah method (Ampere-hour Counting method); and V, correcting and compensating the SOC estimated through the Ah method. In the system, real-time signals of voltage and current sensors access to a microprocessor; processing modules used for executing the method are stored in a program memory, and calculate and directly display real-time SOC estimation values. The method and system can effectively compensate for fitting errors and Ah method accumulative errors, and adjust model parameters on line and in real time, and have the characteristics of fast operation speed, high traceability, and accurate estimation; according to experiments, the SOC estimation precision through the method is high, and the mean absolute error is only 1.28%.
Owner:GUILIN UNIV OF ELECTRONIC TECH
LMNA gene knocked-out cell line constructed on basis of CRISPR/Cas9 technology
InactiveCN108410911APrecise and Efficient KnockoutGenetically modified cellsStable introduction of DNAPremature agingPremature senility syndrome
The invention discloses an LMNA gene knocked-out cell line. The cell line is a 293T cell line or a HePG2 tumor cell line. Cells to be knocked out are transfected by plasmid vectors constructed by twopairs of gRNA as shown in SEQ ID NO. 1-4 or two pairs of gRNA as shown in SEQ ID NO. 7-10 on the basis of a crispr-cas9 technology, and then are subjected to resistance screening to obtain the cell line. The LMNA gene knocked-out cell line can be used for intervention drug screening cell models for diseases such as dilated cardiomyopathy, fat metabolic disorder syndrome and premature aging syndromes.
Owner:GUANGXI MEDICAL UNIVERSITY
Method for knocking out KDM2A gene of HEK293T cells with CRISPR-CAS9 technology
InactiveCN108504657AConducive to research proliferationGood for studying the effects of apoptosisHydrolasesGenetically modified cellsT cellProtein level
The invention provides a method for knocking out a KDM2A gene of HEK293T cells with a CRISPR-CAS9 technology. The method comprises the steps as follows: (1), cell transfection; (2), cell genome extraction; (3), PCR identification; (4), gene level verification; (5), protein level verification: whether K3, K7-1 and K7-2 are KDM2A gene-deficient is further verified by Western blotting after a mutantcell line is verified at the gene level. The invention further provides a KDM2A knockout HEK293T cell line prepared with method and an application of the KDM2A knockout HEK293T cell line as a cell model in study of cell proliferation and apoptosis signaling pathways involved in KDM2A methylase.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
Caco-2 cell model for CRISPR/CAS9-mediated drug transporter targeted knockout and method thereof
The invention discloses a caco-2 cell model for CRISPR / CAS9-mediated drug transporter targeted knockout and a method thereof. The method is used for non-diagnostic or therapeutic purposes and comprises the following steps: designing sgRNA with target specificity for P-gp, BCRP and MRP2 transporters and constructing a sgRNA expression vector, wherein a sequence of the designed sgRNA is shown as SEQID NO. 1-6 in a sequence table; respectively designing P-gp, BCRP and MRP gene single knockout and pairwise combination double knockout by utilizing CRISPR / CAS9, co-transfecting a caco-2 cell with anhCas9 plasmid and performing monoclonal expansion culture to obtain the caco-2 cell model for transporter gene targeting. The caco-2 cell model obtained by the method disclosed by the invention has the beneficial effects that the mutual interference among different transporters is effectively eliminated, and a more specific and more sensitive cell model is provided for drug transport research.
Owner:SOUTH CHINA UNIV OF TECH
CRISPR/Cas9-gRNA targeting sequence pair, plasmid and HD cell model of HTT
ActiveCN108690844AGood gene editing activityEasy to buildGenetically modified cellsNervous system cellsNerve cellsNeuron
The invention discloses a CRISPR / Cas9-gRNA targeting sequence pair, a plasmid and an HD model of HTT, and relates to the field of biotechnology. The targeting sequence pair of the invention comprisesan L sequence and an R sequence. The base sequence of the L sequence is shown as SEQ ID NO.1. The base sequence of the R sequence is shown as SEQ ID NO.2. The targeting plasmid of the invention comprises a first vector plasmid and the above-mentioned targeting sequence pair. The targeting sequence pair is constructed into the first vector plasmid. The HD cell model of the invention is obtained byco-transfecting cells with PolyQ Donor plasmids and the above-mentioned targeting plasmids. By using differentiated neuron cells as a carrier to construct the HD cell model, the invention provides a research platform for exploring the influences or changes of mHtt protein on the internal environment of differentiated nerve cells, and studying the changes of various signal pathways, metabolic pathways and intracellular homeostasis caused by mHtt protein in differentiated neuronal cells.
Owner:SOUTHWEST UNIV
CRISPR/Cas9-gRNA targeting sequence pair and targeting plasmid of HTT (Huntingtin) and application thereof
InactiveCN108251451AGood cleavage activityFacilitate model buildingNucleic acid vectorVector-based foreign material introductionHuntingtons choreaHtt gene
The invention discloses a CRISPR / Cas9-gRNA targeting sequence pair and a CRISPR / Cas9-gRNA targeting plasmid of HTT (Huntingtin) and the application thereof, and relates to the technical field of biology. The CRISPR / Cas9-gRNA targeting sequence pair of the HTT comprises an L sequence and a R sequence, wherein the base sequence of the L sequence is shown as a SEQ ID NO.1; the base sequence of the Rsequence is shown as a SEQ ID NO.2 or 3. The CRISPR / Cas9-gRNA targeting plasmid of the HTT comprises a vector plasmid and the targeting sequence pair, wherein the targeting sequence pair is constructed in the vector plasmid. The invention further provides application of the targeting sequence pair to preparation of an HTT gene mutation model. A reliable basis is provided for establishment of an HD(Huntington's Disease) cell model and a transgenic animal model, and development of HD model building and gene therapy is promoted; an experimental foundation is laid for screening of HD treating medicines and HD treating methods.
Owner:SOUTHWEST UNIVERSITY
Robot situational cognitive map constructing and navigating method based on mouse brain location cells
ActiveCN109668566AInstruments for road network navigationNavigational calculation instrumentsLaser rangingComputational model
The invention belongs to the field of robot technologies and application, and relates to a robot situational cognitive map constructing and navigating method based on mouse brain location cells. In the process of exploring the environment, own motion information and image information in the front part are obtained through a robot, and the own motion information is transferred to a grid cell computing model, so that a corresponding location cell model is generated; by defining an event, location information in space and the obtained image information of the robot are encapsulated, and the eventis marked by state neurons; in the process of exploration, the state neurons are constantly generated to cover the entire environment and form a situational cognitive map of the environment; the generated situational cognitive map is utilized, and a global path planning algorithm is adopted to realized robot navigation based on a target; and through a local path planning algorithm, the global path of the robot is further optimized by a laser ranging sensor, and real-time obstacle avoidance and path local optimization of the robot are realized.
Owner:DALIAN UNIV OF TECH
Method for determining minimum distance of road intersections in harbor district
The invention belongs to the technical field of road design, and relates to a method for determining the minimum distance of road intersections in a harbor district. In the method, frequent lane-changing area of harbor district roads connected with the intersections and the intersections are subjected to two-dimensional cell division, and other parts are one-dimensional cells, and a cell model for harbor district roads near the intersections is constructed. The method comprises the following steps of: (1) constructing a driver sensing module; (2) constructing a behavior module; and (3) setting appearing ratios of various vehicles in a main road, speeds of the various vehicles, and departure frequencies of various vehicles, performing simulation experiments under the conditions of different distances of the intersections and different departure frequencies, and analyzing the simulation to obtain a traffic flow space-time map and vehicle delay data so as to obtain the minimum distance of proper intersections under different traffic conditions. By the method, the influence of the distance of the intersections on the road capacity of the harbor district can be accurately reflected, sothat a method for determining the distance of the road intersections in the harbor district under different conditions is provided.
Owner:TIANJIN MUNICIPAL ENG DESIGN & RES INST
Antineoplastic drug screening cell model utilizing STAT3 as target and creation and application thereof
ActiveCN102517373ALow costShort screening cycleMicrobiological testing/measurementVector-based foreign material introductionStimulantUsability
The invention provides an antineoplastic drug screening cell model utilizing STAT3 as target, belonging to the field of biomedicine. The model is created by a reporting system carrier containing an STAT3 specific binding sequence on the basis of active cells with constitutive STAT3, and the model is used for screening treatment medicine of carcinomatous changes and tumors caused by STAT3 constitutive activation. The active cells with the constitutive STAT3 are utilized, so the reporter gene in the model cell is situated at an overactive state, and no additional stimulant is necessary; besides, the obtained stable cell model can be directly used for screening the compounds, thereby not only greatly reducing the screening cost, but also simplifying the whole screening process from cell cultivation, STAT3 activation, compound feed and detection to cell cultivation, compound feed and detection, shortening the screening period, reducing the operation steps, and improving the stability, efficiency and usability of the system, so that the model is more suitable for high throughput medicine screening.
Owner:上海米络凯生物科技有限公司
Cell Culture Media Supplement and Method of Molecular Stress Control
InactiveUS20120028933A1High yieldFunction increaseBiocideHydroxy compound active ingredientsCell culture mediaStressor
A novel class of agents has been identified to serve as cell-guard agents and / or target-specific supplements to increase cell quality and yield, as well as select for target cell populations. Laboratory experiments have demonstrated the use of cell-guard agents and / or target-specific supplements in the bioprocessing of cells as well as in selecting out a desired cell population. Several potential additive agents (both natural and synthetic) have been identified during these studies, including Vitamin D3, NAC, resveratrol, salubrinal, AKT, and tunicamycin (among others) that hold promise for application in cell models. In one embodiment, hypothermic stress regimes are utilized. In another embodiment, normothermic conditions are utilized while other stressors are tested in the processing. The methods of maintaining mass cell cultures and / or selecting out particular cell populations for further research and clinical use represents an important step in therapeutic discovery. The cell-guard agents are process-matched and cell-matched to protect and / or select particular cells during laboratory and clinical manipulation. The components modulate cell stress and survival pathways.
Owner:CPSI HLDG
Device and method for valuting recharge rate of cell
InactiveCN1503399ACircuit monitoring/indicationDifferent batteries chargingCharge rateLaplace transform
In charge rate estimating apparatus and method for a secondary cell, a current flowing through the secondary cell is measured, a voltage across terminals of the secondary cell is measured, an adaptive digital filtering is carried out using a cell model in a continuous time series shown in an equation (1), all of parameters at one time are estimated, the parameters corresponding to an open-circuit voltage which is an offset term of the equation (1) and coefficients of A(s), B(s), and C(s which are transient terms, and, the charge rate is estimated from a relationship between a previously derived open-circuit voltage V0 and the charge rate SOC using the open-circuit voltage V0, V = B(s) DIVIDED A(s)-I+1 DIVIDED C(s)-V0 wherein s denotes a Laplace transform operator, A(s), B(s), and C(s) denote poly-nominal functions of s.
Owner:NISSAN MOTOR CO LTD
Novel lithium ion power cell SOC estimation method
ActiveCN105510829AOvercoming Accuracy ShortcomingsVerify validityElectrical testingLithiumEstimation methods
The invention discloses a novel lithium ion power cell SOC estimation method. The novel lithium ion power cell SOC estimation method is characterized in that a cell equivalent circuit model can be established, and the identification of the parameters of the established cell model can be carried out by adopting the least squares algorithm; according to the cell open-circuit voltage UOCV acquired by identifying the parameters according to the step one and the corresponding SOC relation, a corresponding function can be acquired by adopting a Shepherd model and a Nernst model in a combined manner, and the function is used for the matching of the UOCV and the SOC relation; the state equation and the observation equation of the SOC estimation can be established, and the STF algorithm has the strong robustness related to the model uncertainty and the extremely strong tracking capability related to the breaking state. The verification of the SOC estimation by adopting the EKF algorithm and the STF algorithm can be carried out by the constant current discharging experiment and the UDDS working condition experiment, and according to the result, the accuracy of the SOC estimation is higher by adopting the STF algorithm than adopting the EKF algorithm, and the convergence performance is better.
Owner:SHANDONG UNIV
Use of brown alga polysaccharide sulfate in preventing and treating Parkinson's disease
ActiveCN101301310AImprove securityEnsure long-term medication needsOrganic active ingredientsNervous disorderCholinergic cellsSulfated polysaccharides
The invention discloses a novel application of fucoidan sulfate in prevention and cure of a parkinson disease. According to the experiments of an isolated PD cell model and an in vivo animal model, fucoidan sulfate has a certain neuroprotection effect on DA cholinergic neurons of the PD cell model and animal model and can prevent and cure the PD disease. The fucoidan sulfate of the invention can be natural polysaccharide extracts obtained form brown alga such as kelp, focus, bladder wrack, sea-tangle or chorda filum and also can be materials such as low molecular weight SSPSA or oligosaccharide which are obtained through the degradation of fucoidan sulfate.
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES +1
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