696 results about "Cell model" patented technology

The present invention relates to a computer-implemented method and system for optimizing geometric configurations within thermal energy transfer device comprising at least one thermal energy exchange channel to enhance performance. The method involves obtaining target design criteria for a physical object and defining a unit cell dimensioned such that the thermal energy transfer channel is formed by a matrix of N1 x N2 identical unit cells. Shape optimization is performed at the unit cell level by iteratively modifying the boundary surfaces of solid structures within a unit cell based on criteria including performance. Optimized design parameters are outputted and transferred to production equipment for creating an optimized thermal energy transfer device. This device comprises a matrix of structures arrayed in at least one dimension, derived from optimized unit cell models.

Techniques are described for using machine learning to extract physics-based cell model parameters from battery charge data provided by the battery module of the battery management system. This data may be processed via machine learning techniques in order to periodically update or adapt a physics-based model that may capture cell electrical dynamics and degradation mechanisms. The techniques may utilize a “digital twin” to adaptively charge the battery while preserving the life of the cells.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine prescription efficacy quantification method and system.The method comprises the steps that chemical component spectrums, pharmacodynamic substance contents and biological activity indexes of traditional Chinese medicines forming a prescription are obtained; constructing a multi-target regulation and control network by combining a traditional Chinese medicine-target interaction database according to the chemical component spectrum, the pharmacodynamic substance content and the biological activity index, identifying a core efficacy pathway cluster by adopting a Louvain algorithm, and calculating a pathway activation intensity value by adopting a pathway target membership weighting model; according to the core efficacy pathway cluster, establishing a mapping relation between the core efficacy pathway cluster and traditional Chinese medicine efficacy terms through ontology and semantic mapping, and according to pathway activation intensity values, generating a prescription efficacy intensity vector through a weighted aggregation model; according to the efficacy intensity vector of the prescription, verifying and correcting the network weight through an in-vitro cell model, and generating the efficacy quantification of the prescription in combination with the clinical syndrome calibration coefficient. Therefore, the problems of single data dimension and insufficient quantification result accuracy in the prior art are solved.

The invention relates to the field of biological imaging, and particularly discloses an in-vitro cell microenvironment dynamic monitoring method for two-photon frequency domain fluorescence lifetime imaging, which comprises the following steps: S1, by using a two-photon frequency domain fluorescence lifetime imaging TP-FD-FLIM technology, losslessly representing microenvironment change through fluorescence lifetime parameters, and monitoring oxidative stress reaction and neutrophil migration behavior in real time, analyzing the effect of the associated compound in combination with an in-vitro cell model; and S2, based on the physical basis of FD-FLIM, establishing a frequency domain fluorescence lifetime signal processing and analysis system under periodic excitation, analyzing the dynamic correlation characteristics of the phase delay phi and the modulation depth M of a fluorescence signal relative to exciting light, and carrying out quantitative backstepping on molecular lifetime parameters. According to the in-vitro cell microenvironment dynamic monitoring method for two-photon frequency domain fluorescence lifetime imaging provided by the invention, neuroinflammatory response can be observed in a lossless and real-time manner on the subcellular scale.

The invention discloses a lubricant adsorption and friction regulation and control method based on molecular dynamics simulation, which comprises the following steps: S1, constructing a lubricant molecule and friction pair metal unit cell model, generating topological structure information based on a minimum structure unit, and constructing a lubrication system model with a sandwich structure; s2, giving force field parameters to the lubrication system model, and performing geometric structure optimization and dynamic relaxation; s3, giving surface charges to the upper and lower friction pairs for targeted adsorption simulation of the lubricant; and S4, applying uniformly distributed contact pressure and constant sliding speed to the upper friction pair to perform friction simulation of the lubrication system. According to the lubricant adsorption and friction regulation and control method based on molecular dynamics simulation, a targeted adsorption strategy of a solid-liquid interface is established, the microcosmic adsorption process of the lubricant is reproduced, controllable regulation of friction characteristics is achieved, the human resource cost in actual experiments is reduced, and manual operation errors are reduced.

The invention discloses a rapid equalizing charging method for a lithium ion battery pack, and belongs to the field of battery charging. The method comprises the following steps: step 1, establishing a first-order enhanced equivalent circuit model, constructing an aging model in combination with an Arrhenius equation, and comprehensively establishing an electric heating aging fusion model; 2, constructing a battery pack model through series connection based on a single battery model of the electrothermal aging fusion model; 3, configuring a deep reinforcement learning environment on the basis of the electrothermal aging coupling model, wherein the deep reinforcement learning environment is used for simulating the real state of interaction between a deep deterministic policy gradient algorithm (DDPG) and the battery pack in deep reinforcement learning; 4, a deep reinforcement learning Actor network, a Critic network and a reward function are constructed, and the target of the reward function is defined as the shortest charging time of the battery pack, SOC (state of charge) balance and minimum aging loss so as to support operation and result evaluation of a DDPG algorithm; and 5, training the model to obtain the optimal fast equalization charging current.

The invention relates to the technical field of medicines, in particular to a construction method and application of a photothermal conversion platform for treating osteoarthritis by regulating synovial macrophage polarization. According to the present invention, the M2 membrane-structured black phosphorus selenium carbon body (M2-BPSeC) photo-thermal nano-platform is innovatively provided, the triple functions of bionic targeting delivery, precise thermal control intervention and immune microenvironment remodeling are integrated, and the excellent synergistic treatment effect is represented in the in-vitro cell model and the OA animal model. The technology breaks through the technical bottleneck that traditional treatment is insufficient in targeting and single in intervention dimension, precise functional coupling of the physical thermal effect and immunoregulation is achieved for the first time, and a brand new strategy of targeting-temperature control-immunity integration is provided for osteoarthritis treatment. The efficient and controllable preparation process and the remarkable multi-dimensional treatment effect open up a new path for cartilage regeneration and immune balance regulation and control.

The invention relates to the technical field of fuel cells, and provides a method and a device for optimizing operation conditions of a proton exchange membrane fuel cell. The method comprises the following steps: simulating the proton exchange membrane fuel cell according to a local dimension reduction single cell model and initial operation conditions of the proton exchange membrane fuel cell to obtain initial effective output power; sequentially increasing each initial parameter value under the initial operation condition to obtain a target operation condition; simulating the proton exchange membrane fuel cell again according to the target operation condition and the local dimensionality reduction single cell model to obtain the target saturation of liquid water of the cathode catalyst layer and the target effective output power; and obtaining a performance evaluation value corresponding to the target operation condition according to the initial effective output power, the target effective output power and the target saturation degree of the liquid water of the cathode catalyst layer, so as to determine the target operation condition corresponding to the performance evaluation value as the optimal operation condition. By adopting the method, the precision of the performance evaluation value can be improved, and the optimization effect of the operation condition is further improved.

The invention provides a micro-fluidic organ chip for three-dimensional cell culture. The micro-fluidic organ chip comprises a cell model loading and culturing unit, a liquid inflow-outflow unit with height difference, and an embedded inverted cone compression ring sealing unit, the cell model loading and culturing unit is constructed by overlapping at least three layers of chips up and down; and the liquid inflow-outflow unit with the height difference is constructed and formed by respectively forming liquid circulation holes which are hermetically connected through the embedded inverted conical compression ring sealing unit on at least three layers of chips. According to the invention, the cell culture space is expanded through the cell model loading and culture unit, high compatibility of cell culture is realized, and the problem of non-uniform concentration of a test substance is eliminated through the liquid inflow-outflow unit with height difference; and high-reliability miniaturized sealing design is realized through the embedded inverted cone pressing ring sealing unit, and the device can be widely applied to culture of cell models and test substance treatment and effect index detection taking toxicological and pharmacological researches as target scenes.

Provided is a mammalian-derived cell model that can be used in anti-aging drugs. The mammalian-derived extraembryonic trophoblast cell model is an early mammalian-derived extraembryonic stage. A change model and an aging evaluation index system for differentiating the cells into the extraembryonic trophoblast cells / organoids can be used for various anti-aging researches and target detection, anti-aging drug detection, screening and identification, research on innovative drugs / natural products, and development of chemicals and / or health foods and additives. Screening and identifying many resistances is helpful. Candidate targets of aging may be further mechanically and functionally validated for future therapeutic use. The screening of anti-aging drugs or natural products will produce huge economic and social benefits.

The invention provides kelp fucoidin with low molecular weight and high anti-anaphylaxis as well as a preparation method and application thereof, and belongs to the technical field of food processing. The preparation method comprises the following steps: mixing kelp fucoidin with water to obtain a kelp fucoidin solution; and mixing the kelp fucoidin solution with H2O2 and Vc, reacting, adjusting the pH value, dialyzing and freeze-drying to obtain the kelp fucoidin with low molecular weight and high anti-allergic property. The H2O2-Vc degradation system is innovatively applied to preparation of the low-molecular-weight kelp fucoidin and improvement of the anti-allergic activity of the low-molecular-weight kelp fucoidin. In the degradation process, the chemical composition of the fucoidin is partially changed, but monosaccharide types and functional groups are not influenced. Through multiple ways of cell model and animal model experiments, the degraded laminaria fucoidin is more prominent in anti-allergic activity. Technical support is provided for development of seaweed-derived anti-allergic functional active substances, and high-valued utilization of kelp resources in the fields of functional food and medicines is further promoted.

The invention discloses a three-dimensional woven composite material reverse design method based on a generative adversarial neural network. The method comprises the following steps: selecting three-dimensional woven composite material samples of different process structures through super-Latin sampling; a Python script is combined with TexGen textile modeling software to generate a three-dimensional woven composite material unit cell model, and Abaqus is imported to calculate the mechanical property of the material; normalized coding is carried out on the process structure of the three-dimensional woven composite material, mechanical properties of the material are combined to serve as a data set, a generative adversarial neural network is trained, and hyper-parameters are optimized through Bayesian. According to the method, mapping between the technological parameters and the mechanical properties of the three-dimensional woven composite material is established through the generative adversarial neural network model, the design, research and development efficiency of the three-dimensional woven composite material can be improved by more than 50%, and the structural design accuracy and the performance prediction accuracy of the three-dimensional woven composite material are improved.

The invention discloses a piezoelectric ceramic fatigue life analysis method based on macro and micro multi-scale. The method comprises the following steps: firstly, automatically establishing a microcosmic unit cell model based on a Python script, realizing automatic assignment of material parameters and application of periodic boundary conditions, and calculating microcosmic unit cell homogenization mechanical parameters; then constructing a macroscopic driver model, inputting microscopic parameters as material attributes, and performing macroscopic fatigue life prediction and damage distribution simulation in combination with a Miner linear damage accumulation theory; and finally, through macro-micro coupling analysis, transmitting the strain of the macroscopic maximum stress unit to the micro model, and researching the intergranular stress distribution characteristics and the interface damage evolution law of the piezoelectric ceramic. According to the method, a multi-scale modeling strategy is adopted, cross-scale fatigue performance prediction from the micro grain scale to the macro structure scale is achieved, and an effective means is provided for reliability design and service life evaluation of the piezoelectric ceramic driver.

The invention belongs to the technical field of biology, and particularly relates to a porcine epidemic diarrhea virus broad-spectrum neutralizing antibody and application thereof. A porcine epidemic diarrhea virus broad-spectrum neutralizing antibody 6G2 is screened, the virus neutralizing activity of the antibody is evaluated through a cell model, and it is found that the antibody can effectively block infection of G1a, G1b, G2a, G2b, G2c and S-INDEL (porcine epidemic diarrhea virus) gene subtype strains with high epidemic rate on cells. Further, animal infection experiments of pigs prove that the neutralizing antibody provided by the invention has good prevention and treatment effects on the porcine epidemic diarrhea virus, and has important significance on improving the capability of preventing and controlling porcine epidemic diarrhea in a pig farm.

The invention belongs to the technical field of microorganisms, and particularly relates to an oligopeptide from lactobacillus plantarum extracellular vesicles and application of the oligopeptide. Specifically, the lactobacillus plantarum extracellular vesicles can recover the skin barrier; the expression of proinflammatory factors in a cell inflammation model can be reduced, and a relatively good anti-inflammatory effect is achieved. Metabolome analysis shows that effective substances having effects on skin barrier injury comprise oligopeptide KLQ; kLQ can regulate skin barrier related gene expression in the SDS-induced damaged cell model; and the expression of skin inflammation-related genes in the SDS-induced damaged cell model is regulated, so that the SDS-induced SDS-induced damaged cell model can be used as a medicine for treating skin barrier injury.

The invention aims to provide a chlorella pyrenoidosa peptide with an effect of preventing alcoholic liver injury, which is prepared by the following steps: crushing chlorella pyrenoidosa, mixing with water, freezing and thawing, and performing ultrasonic treatment to prepare homogenate; alkaline protease is added for enzymolysis, and then flavourzyme is added for enzymolysis; and after the enzymolysis product is adsorbed by activated carbon, the supernate is adsorbed by using an SP Sephadex C25 cation exchange medium. The amino acid sequence of the chlorella pyrenoidosa peptide is PSEQ ID NO: 1-5. The chlorella pyrenoidosa peptide provided by the invention is obtained by enzymolysis, adsorption and cation exchange chromatography technologies, and is verified by a HepG2 cell model to obviously relieve alcoholic liver injury. The raw materials are natural and safe, the process is accurate and efficient, and industrialization potential is achieved. Meanwhile, the peptide is suitable for development of functional food, health care products and medicines, and a low-toxicity and sustainable liver protection solution is provided.

The invention belongs to the technical field of biology, and particularly relates to a human metapneumovirus mouse adapted strain and application thereof. Compared with a wild strain, the strain has higher susceptibility to animals; the strain can be used for treating BALB / c mice and can cause typical clinical symptoms and even death, for example, after the strain infects the BALB / c mice, the disease symptoms are obvious, the weight of 83% infected mice is severely reduced to 75% or below and reaches the humanity killing standard, and the death rate reaches 50% or above 4 days after the strain infects the BALB / c mice; the strain can be used for constructing a cell model or an animal model of human metapneumovirus infection or diseases caused by the human metapneumovirus infection, and is further used for screening drugs for preventing and / or treating the human metapneumovirus infection or the diseases caused by the human metapneumovirus infection. In addition, the strain can also be used for preparing medicines for preventing and / or treating human metapneumovirus infection or diseases caused by the human metapneumovirus infection, preparing antibodies or antiserum for resisting the human metapneumovirus and the like.

The invention provides a TF and Her2 targeting bispecific antibody coupling drug as well as a preparation method and application thereof, and belongs to the technical field of biological drug preparation. The bispecific antibody provided by the invention can target TF and / or Her2 antigens in tumor cells, and has the advantages of high stability, easiness in expression, purification and coupling and the like. The bispecific antibody can be specifically combined with a tumor surface antigen and internalized into tumor cells, so that the tumor cells can be specifically killed. The bispecific antibody coupling drug prepared on the basis of the bispecific antibody has a good tumor inhibition effect in a cell model and an animal model, is nontoxic and harmless to animals, and has an excellent cancer treatment potential.

The invention discloses a group of pyemia specific biomarkers and application thereof, and belongs to the field of medical detection.The biomarkers are formed by combination of alpha 1-microglobulin / Bikunin precursor protein and one or more of antithrombin III protein, apolipoprotein A1 or apolipoprotein H, according to the invention, seven core proteins, namely APOA1, APOH, AMBP, SERPINC1, F2, FGG and FGB, are screened from TMT proteomics of serum of a clinical hemorrhagic patient, and four more important proteins, namely APOA1, APOH, AMBP, SERPINC1, F2, FGG and FGB, are obtained by further screening the seven proteins in a hemorrhagic cell model and the clinical hemorrhagic patient. The four proteins are verified again in serum of a hemorrhagic mouse animal experiment and an expanded-scale clinical hemorrhagic patient, and the potential of the four core proteins as serum biomarkers for early diagnosis of hemorrhagic disease is determined.

The invention relates to the technical field of underwater low-frequency sound insulation superstructures, and discloses a pressure-resistant underwater low-frequency sound insulation superstructure based on a TPMS (Tire Pressure Monitor System) and a design method thereof, a two-dimensional section cell is intercepted and obtained on a Gyandroid lattice cell model along a sound wave incidence direction, and the characteristic that the modulus in the sound wave incidence direction is reduced and is easy to deform is utilized, so that the sound insulation performance of the sound insulation superstructure is improved, and the sound insulation performance of the sound insulation superstructure is improved. Low impedance is realized; the internal structure distribution of the cells is changed through stretching, so that the cells have anisotropy, the modulus of the cells in the sound wave incidence direction is reduced, and the impedance is further reduced; by introducing a material main shaft deflection angle, quasi longitudinal waves and quasi transverse waves in the structure are excited, and the longitudinal waves incident in water are converted into transverse waves in the structure through longitudinal-transverse wave conversion, so that the sound insulation performance is improved; performing periodic array arrangement, intercepting to obtain a core layer configuration under a two-dimensional plane, and performing structure materialization to obtain a sound insulation layer; the two sides of the sound insulation layer are covered with cover plates, and the pressure-resistant underwater low-frequency sound insulation superstructure based on the TPMS is obtained.

The invention discloses a method and a system for measuring an electrode constant of an oil conductivity valuing device, relates to the technical field of measurement, and breaks through the limitation of roughly taking an average value of an area of a polar plate traditionally by constructing an actual conductance cell model and defining parameter information, accurately deduces a conductance cell constant, and reversely calculates an effective relative area to determine the electrode constant. According to the method, the coaxial annular structure characteristics are attached, the influence of the edge effect and electric field line diffusion is avoided, and electrode constant calculation is more scientific and rigorous. Therefore, the accuracy of the constant value of the oil conductivity standard substance is guaranteed, a reliable reference is provided for verification and calibration of an oil conductivity meter, an effective oil conductivity measurement result is ensured, the electrostatic accident risk is reduced from the source, and the oil fuel quality and safety management and control are enhanced. The problems that an existing coaxial annular cylinder type electrode conductance cell is not strict in constant calculation and low in standard value credibility are effectively solved, and the electrode constant measurement accuracy of the oil conductivity valuing device is remarkably improved.

The invention belongs to the field of biological medicine, and particularly relates to application of deaminotyrosine in preparation of a medicine for treating vascular calcification symptoms. The invention finds that deaminotyrosine can significantly reduce the vascular calcification degree of an in-vitro cell model and an in-vivo animal model by inhibiting osteogenic differentiation and calcium salt deposition of vascular smooth muscle cells; therefore, the invention provides a new application of the deaminated tyrosine or pharmaceutically acceptable salt, ester, solvate or prodrug thereof in preparation of drugs for treating vascular calcification symptoms. The invention also provides a pharmaceutical composition, which takes deaminated tyrosine as an active component, and provides a brand new drug choice for clinical prevention and treatment of vascular calcification.

The invention discloses a combined evaluation method for in-vitro and in-vivo red fading and relieving effects of cosmetic raw materials, which comprises the following steps: in-vitro model evaluation: inducing a human immortalized umbilical vein endothelial cell model by adopting TNF-alpha, and detecting the secretion amount of a prostacyclin I2 factor to obtain a score of an in-vitro model; in-vivo model evaluation: adopting a chick embryo chorioallantoic membrane model, and obtaining a score of the in-vivo model according to the degree of vasoconstriction caused by the to-be-detected raw material sample acting on the chick embryo chorioallantoic membrane; and comprehensive evaluation: based on the score of the in-vitro model and the score of the in-vivo model, comprehensively evaluating the red fading and relieving efficacy of the raw material sample to be tested. According to the technical scheme, the defect that in the prior art, no cosmetic raw material soothing efficacy evaluation method for the vascular reactivity increasing mechanism exists is overcome, efficacy evaluation is more accurate, the method has the advantages of being comprehensive, short in test period, easy to operate, economical and convenient, and an effective reference basis is provided for screening and compounding schemes of red fading and soothing raw materials.

The invention provides application of coniferyl aldehyde in eye protection products, and belongs to the technical field of eye health. The coniferyl aldehyde is found to have an eye protection effect for the first time, and particularly has a protection effect on retina light injury. Cell model and animal model experiments prove that coniferyl aldehyde has a protective effect on eye cell apoptosis, retina light injury and the like, so that coniferyl aldehyde can be applied to development and application of drugs for treating retina light injury diseases and functional products for relieving visual fatigue and the like.

The invention relates to the technical field of digital cell models, in particular to a construction method and system of a digital cell model and a storage medium. The method comprises the following steps: acquiring target cell data, extracting a target cell structure, and performing molecular physiological function analysis in combination with the cell structure and the data to obtain molecular physiological function data of cells; performing cell molecule metabolism network analysis to obtain cell molecule metabolism network data, and constructing a digital cell model; through the model, the reaction of the cells under the environmental pressure can be simulated, the attenuation of the physiological state of the cells can be estimated, and then the gene defects of the cells can be analyzed; according to the cell gene defect, adjusting the target cell data to obtain cell gene adjustment data; according to the method, the cell model is constructed, so that the dynamic change analysis of the cells is more accurate.

The invention belongs to the field of fuel cells in the field of chemical engineering, and particularly relates to a quasi-two-dimensional multi-physical field modeling method of a reversible solid oxide fuel cell. The method is a universal quasi-two-dimensional multi-physical field modeling method which considers dynamic processes such as electrochemical reaction, heat transfer, gas diffusion and conversion in the reversible solid oxide fuel cell, explores an electricity-hydrogen-heat coupling relation in a single cell and can describe the distribution condition of physical variables in the airflow direction. According to the invention, a general battery electrochemical model formula is adopted, and the mode switching can be easily carried out by changing the symbol of the current density (the fuel battery mode is' + ', and the electrolytic cell mode is'-'); a finite volume method thought is adopted, a single battery model is simplified into a channel model, and five temperature layers are considered; three dynamic processes of heat transfer, gas diffusion and conversion are calculated according to the law of conservation, and thermoelectric data and other model parameters are obtained.

The invention discloses a TMPRSS2 protein inhibitor efficacy prediction calculation method. A scoring function is constructed through a logP value, a virtual docking score and living cell inhibitor effect data to predict a drug inhibition effect. The method specifically comprises the following steps: constructing a TMPRSS2 overexpression cell model to screen drugs; the cell viability of various potential inhibitors is detected, and high-toxicity inhibitors are eliminated through a CCK-8 experiment; using flow cytometry to detect the cell average fluorescence intensity through a TMPRSS2 fluorescent probe to evaluate the enzyme activity influence of the inhibitor, and calculating the IC30 value; measuring the logP value of an effective inhibitor, and predicting the binding capacity of the effective inhibitor and TMPRSS2 by using Schrodinger software to obtain a virtual docking score; and analyzing the relationship among the IC30 value, the logP value and the virtual docking score, and constructing a scoring function to predict the drug effect. According to the method, the drug effect prediction can be simply, conveniently and quickly carried out, the drug screening consumption is reduced, and the drug screening period is shortened.

The invention provides a method for inducing HL-60 cells to be differentiated into neutrophil-like cells, and belongs to the technical field of cell culture. According to the method, the induced differentiation efficiency of the HL-60 cells to the neutrophil-like cells (D-HL-60) and the cell quality are remarkably improved, high-proportion functional D-HL-60 cells can be obtained, a good motility rate can be maintained, and a stable and reliable cell model is provided for researching a neutrophil differentiation mechanism, screening related drugs and analyzing immune functions. Particularly, the functional D-HL-60 cells obtained on the basis of the method can be used as an ideal model, deep analysis of neutrophil trapping nets (NETs) in inflammation and tumor pathological mechanisms is assisted, and an experimental basis is provided for development of therapeutic strategies of targeted NETs.

According to the vaginal mucosa repairing composition containing the rose component and the application, the vaginal mucosa repairing composition achieves multiple effects of inhibiting pathogens, relieving inflammation and repairing mucosa through the synergistic effect of the LGG fermentation product and the rose component. According to the in-vitro verification method based on the vaginal mucosa epithelial cell 3D model, an in-vivo multi-layer mucosa structure and a complex microenvironment are accurately simulated, the barrier function, inflammation regulation and control and cell proliferation capacity of the vaginal mucosa repair composition are accurately evaluated, and the mucosa barrier function and multi-cell interaction are reflected.

The invention discloses an application of a Beclin 1 targeting pharmaceutical composition in preparation of antitumor drugs. The pharmaceutical composition comprises stapled peptides targeting Beclin 1 and platinum chemotherapeutic drugs. The treatment effect of the pharmaceutical composition on ovarian cancer is verified through an in-vitro cell model and an in-vivo mouse model, the combined use of the stapled peptide i7-01s-31 targeting Beclin 1 and cis-platinum can further amplify the anti-tumor effect of the stapled peptide i7-01s-31 and cis-platinum, the synergistic interaction effect is achieved, and the pharmaceutical composition can be used for treating ovarian cancer. The problem that drug resistance is easily generated due to single use of cis-platinum in actual clinical application is avoided; meanwhile, the dosage of chemotherapeutic drugs can be reduced through drug combination, so that the treatment safety is improved, and the toxicity is reduced.