39 results about "Sulfated polysaccharides" patented technology

The invention discloses an analysis method for determining the content of galactosamine in sulfated polysaccharide based on high-temperature hydrochloric acid hydrolysis and an ion chromatograph method, which comprises the following steps: hydrolyzing a test sample with hydrochloric acid at high temperature to release galactosamine, separating with an ion chromatograph and a sugar analysis column, detecting with a pulsed ampere detector, and determining the content of galactosamine in sulfated polysaccharide according to a galactosamine reference substance. And quantitatively analyzing the content of galactosamine in the test sample. The method disclosed by the invention has the advantages of simplicity, rapidness, accuracy, high efficiency, no need of derivation treatment and the like.

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

The present invention relates to a two- or three-layer film composition for periodontal use, comprising a hydrophobic polymer outer layer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

This invention provides a method for preparing sulfated polysaccharides suitable for the production of microcapsules. [Solution] The present invention relates to a method for preparing sulfated polysaccharides. A mixture comprising at least one polysaccharide and at least one polar aprotic solvent is prepared in this method. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, and the mixture is then subjected to a temperature treatment so that at least one polysaccharide is converted to at least one sulfated acetate polysaccharide. At least one sulfated acetate polysaccharide is separated from the mixture and converted to a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and methods for producing microcapsules.

The disclosure provides application of sulfated polysaccharides in resisting novel coronavirus, belonging to the technical field of biomedicine. It is confirmed in the disclosure that by binding to an S protein on the surface of the SARS-CoV-2 virus, the sea cucumber polysaccharides, fucoidans or carrageenans can prevent cell membranes of body cells from adsorbing and internalizing the SARS-CoV-2 virus, thereby preventing the SARS-CoV-2 virus from infecting the body cells, which indicates that the sea cucumber polysaccharides, fucoidans or carrageenans have the effect of prevention and treatment of pneumonia caused by the novel coronavirus. These polysaccharides can be used to prepare protective articles having functions of prevention and treatment of novel coronavirus infection, for example: inhalations, hand lotions, oral liquids and respirators.

The invention relates to a composite in the form of a two-or three-layer film for periodontal use, comprising an outer layer of a hydrophobic polymer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The application discloses a kind of fibroblast growth factor 2 and mesenchymal cell co-loaded freeze-dried collagen support and its preparation method and application, belong to the technical field of biomedical materials, by adding sulfated polysaccharide to collagen solution, it is formed freeze-dried collagen support containing sulfated polysaccharide by vacuum freeze-drying, it is combined with fibroblast growth factor 2 incubation, obtain the freeze-dried collagen support of loading fibroblast growth factor 2, again mesenchymal cell is inoculated in the freeze-dried collagen support of loading fibroblast growth factor 2, and the freeze-dried collagen support of fibroblast growth factor 2 and mesenchymal cell co-loading is prepared.The support obtained by the application can efficiently combine fibroblast growth factor 2, support the adhesion growth of mesenchymal cell simultaneously, promote mesenchymal cell to migrate to the inside of support, realize the uniform distribution of cell in support, and can promote angiogenesis, provide new and efficient carrier for cell transplantation treatment.

The invention belongs to the technical field of marine polysaccharides, and relates to an anti-hypoxia urechis unicinctus body cavity fluid sulfated polysaccharide as well as a preparation method and application thereof. The weight-average molecular weight of the polysaccharide is 1000-50000 Da, the mass fraction of sulfate radicals is 10.0%-30.0%, and monosaccharide is prepared from galactose, ribose, fucose, glucosamine, mannose and glucose. The preparation method comprises the following steps: inducing controlled degradation of a main chain through high-temperature hot water extraction, carrying out proteolysis deproteinization, carrying out graded ethanol precipitation interception and carrying out anion exchange chromatography purification. The polysaccharide shows a remarkable protective effect in a nerve cell hypoxia simulation model, has excellent free radical scavenging activity, and can be used for preparing medicines, antioxidants, functional foods and the like for preventing or treating hypoxia-related diseases.

The present invention relates to a method for preparing sulfated polysaccharides, in which a mixture is prepared comprising at least one polysaccharide and at least one polar aprotic solvent. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, which is then subjected to a temperature treatment, thereby converting the at least one polysaccharide into at least one sulfated acetate polysaccharide. The at least one sulfated acetate polysaccharide is separated from the mixture and converted into a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and a method for producing the microcapsules.

The application discloses a positive electrode material and a preparation method and application thereof. The positive electrode material comprises a core and a coating layer arranged on the surface of the core, and the coating layer contains lithium polysaccharide sulfate. In the application, the core is coated with lithium polysaccharide sulfate, so that the stability of the positive electrode material is improved, especially the stability in a liquid electrolyte, and the electrical performance of the material is improved.

The present invention relates to a biomaterial comprising at least one elastomer matrix and a polysaccharide, and to its use in the reinforcement, reconstruction and / or filling of tissues, preferably in the reinforcement, reconstruction and / or filling of soft and / or epithelial tissue defects, preferably in the repair of skin and / or mucosa.

The invention is directed to a stable composition wash composition. The wash composition comprises a mixture of naturally derived and biodegradable sulfated polysaccharides. The wash composition has a viscosity of 40,000 cps or less, and surprisingly, is free of syneresis, discoloration and malodor, even after being stored at elevated temperatures.

The invention discloses a maltodextrin-included emulsified feed microcapsule and a preparation method thereof, and belongs to the technical field of pig feed. The emulsified feed microcapsule comprises a microcapsule wall material and a core material, and the core material comprises the following raw materials in parts by mass: 12-18 parts of bean pulp with skin, 35-50 parts of corn, 7-13 parts of broken rice, 1-5 parts of protein powder, 4-9 parts of corn bran, 3-6 parts of highland barley powder, 0.1-0.8 part of a compound enzyme preparation, 0.5-1.2 parts of a compound strain liquid, 2-4 parts of vegetable oil, 0.1-0.6 part of an emulsifier, 0.5-1.5 parts of amino acid and 0.2-0.8 part of sulfated polysaccharide; the microcapsule wall material is prepared from the following raw materials in parts by mass: 30 to 50 parts of maltodextrin, 8 to 12 parts of sodium caseinate and 0.5 to 2 parts of pectin-anthocyanin graft. The prepared emulsified feed microcapsule is high in embedding rate, can be quickly dissolved in water, and can reduce the diarrhea rate of piglets.

The invention discloses an anti-HPV (human papillomavirus) underwear laundry detergent based on a sulfated polysaccharide compound system, which is prepared from the following raw materials in percentage by mass: 0.3 to 2 percent of sodium citrate, 6 to 12 percent of fatty alcohol polyoxyethylene ether sodium sulfate, 4 to 10 percent of fatty alcohol polyoxyethylene ether sodium sulfosuccinate, 1.5 to 5 percent of cocamidopropyl betaine, 2 to 6 percent of lauramide propyl hydroxy sulfobetaine and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 2 to 8 percent of alkyl glycoside, 2 to 6 percent of potash soap, 0.1 to 0.3 percent of citric acid, 0.2 to 0.5 percent of protease, 0.8 to 2.5 percent of sulfated polysaccharide, 0.2 to 0.5 percent of silver ion, 0.2 to 0.6 percent of dichloro, 0.1 to 0.2 percent of Kathon, 0.2 to 0.5 percent of essence, 0.5 to 1.5 percent of sodium chloride and the balance of deionized water. According to the invention, a brand-new ternary synergistic antiviral system composed of sulfated polysaccharide, silver ions and diclosan is creatively constructed, and the inactivation rate of the system to pseudoviruses HPV-16 and HPV-18 is increased to gt; compared with a binary combination with the optimal effect, the activity of the compound is improved by more than one order of magnitude, and the qualitative change from partial inhibition to complete removal is realized. The efficient cleaning capacity brought by the synergistic effect can cut off the path of contact transmission of viruses through fabrics such as underwear from the source, and a feasible solution is provided for daily physical prevention of HPV-related infection.

Methods for the treatment of Acute Respiratory Distress Syndrome (ARDS), particularly ARDS caused by viral infections such as influenza and SARS-CoV-2, comprising the administration of pentosan polysulfate (PPS) are provided. Some provided methods comprise the administration of sodium pentosan polysulfate. Prophylactic methods comprising the administration (for example, intra-nasally) of sodium pentosan polysulfate to inactivate a vims which is causative of ARDS are also provided.

The invention discloses a triple dynamic immune defense compound nutrient as well as a preparation method and application thereof, and relates to the technical field of immunity. The composition consists of red algae sulfated polysaccharide, beta-glucan, an elderberry extract, an echinacea purpurea extract, lactoferrin, nano-selenium, nano-zinc, citric acid and high fructose corn syrup according to a specific ratio. The core of the invention lies in that a triple dynamic immune defense shield theory of'oropharyngeal mucosa barrier (immediate defense)-system immune activation (short-term mobilization)-specific immune regulation (long-term consolidation) 'is proposed and constructed in the field of food for the first time, and through the cooperation of multiple mechanisms of physical blocking, biological inactivation, immune training and long-term regulation, the immunity of the oral pharyngeal mucosa is enhanced. And broad-spectrum prevention and auxiliary intervention on various viruses are realized. All the raw materials with homology of medicine and food and the food nutrition enhancer are adopted, so that the safety is high, and the applicable crowd is wide.

The present invention relates to the field of batteries, and more specifically to a separator and a battery comprising the separator. The separator comprises a substrate layer and a coating applied to at least one surface of the substrate layer. The coating comprises inorganic particles and a functional binder. The functional binder comprises a sulfated polysaccharide material, wherein the sulfur content of the sulfated polysaccharide material accounts for 0.1% to 30% of the total weight of the sulfated polysaccharide material. The separator of the present invention has good adhesion, can effectively increase the hardness of the battery, and prevent battery deformation.

The invention discloses a method for isolating sulfated polysaccharides from Gracilaria tenuistipitata. The method includes collection of sample, sample processing, extraction of sulphated polysaccharides, characterization using spectroscopic techniques and estimation of total carbohydrate and sulphate content to confirm structural and functional properties to yield high-purity sulphated polysaccharides with preserved bioactivity.

This application discloses a complex polysaccharide, its preparation method, and its applications. It discloses both a novel use of sulfated kudzu polysaccharide as a raw material for preparing drugs with anticoagulant effects and a complex polysaccharide comprising sulfated polysaccharide and polysaccharide fragments; wherein the sulfated polysaccharide includes sulfated kudzu polysaccharide and / or sulfated Bletilla striata polysaccharide; and the polysaccharide fragments include glycosaminoglycan fragments. This application modifies the structure of natural polysaccharides to improve their structural properties, preparing and screening complex polysaccharides with anticoagulant activity. The components in the complex polysaccharide work synergistically, significantly enhancing the anticoagulant effect and broadening the application fields of polysaccharides, primarily for the development of anticoagulant drugs and anticoagulant medical devices.

The present invention relates to an aqueous cosmetic composition containing a sulfated polysaccharide derived from Aphanothece sacrum, a colouring pigment or a pearlescent pigment, and an aqueous medium, wherein a content of sulfated polysaccharide derived from Aphanothece sacrum in the aqueous cosmetic composition is 0.03% by mass or more, and the colouring pigment or the pearlescent pigment is not subjected to a hydrophilization treatment on its surface; and a cosmetic product containing the aqueous cosmetic composition.

The invention belongs to the technical field of polysaccharides, and particularly discloses application of sulfated seaweed polysaccharides in preparation of anti-hepatic fibrosis drugs. According to a structural unit of the seaweed sulfated polysaccharide SPW-05-S2, 1, 4-beta-glucuronic acid and 1, 2-alpha-mannose are alternately connected to form a main chain, mannose, xylose, galactose and fucose form branch chains, the branch chains are located on the C-6 site and the C-3 site of the 1, 2-alpha-mannose, and the branch chains are located on the C6 site and the C-3 site of the 1, 2-alpha-mannose. The branches consist of galactose residues, xylose residues, mannose residues and fucose residues. In-vitro experiments prove that the polysaccharide can be used for remarkably inhibiting the expression of fibrosis related proteins (Fibronectin, Collagen I and alpha-smooth muscle actin), and can be used for remarkably inhibiting the expression of the fibrosis related proteins (Fibronectin, Collagen I and alpha-smooth muscle actin). Meanwhile, the surface plasmon resonance technology finds that the polysaccharide can be combined with PI3K protein. Therefore, the polysaccharide has a potential anti-hepatic fibrosis effect and is expected to become a candidate saccharide drug for treating hepatic fibrosis.

The invention relates to Chinese wolfberry sulfated polysaccharide as well as a preparation method and application thereof. The sulfated lycium barbarum polysaccharide is a sulfated derivative of lycium barbarum polysaccharide with the sulfated substitution degree of 0.80, and sulfated sites of the sulfated lycium barbarum polysaccharide comprise the third site and the fifth site of terminal-alpha-arabinose, the second site and the third site of 1, 5-alpha-arabinose, the sixth site of terminal-beta-galactose and the fourth site of 1, 3, 6-beta-galactose. The lycium barbarum sulfated polysaccharide provided by the invention has a huge application prospect in the aspect of candidate drugs for preventing and / or treating aging bone loss, and compared with lycium barbarum sulfated polysaccharide in the prior art, the lycium barbarum sulfated polysaccharide provided by the invention has an effect of inhibiting bone resorption; the reason may be that the sulfated lycium barbarum polysaccharide is superior to lycium barbarum polysaccharide in the aspect of improving the bone phenotype of the aged mouse.

The invention discloses a preparation method and application of sea cucumber polysaccharide, and belongs to the field of food and medicine. According to the method, the sea cucumber intestines are used as raw materials, only the sea cucumber intestines are simply washed in the pretreatment stage, on one hand, polysaccharide loss caused by excessive treatment is avoided, on the other hand, a natural grinding medium is provided for subsequent use of bone paste grinding homogenate, and tissue breaking is facilitated; and then the sand grains and the tissue homogenate are separated through standing. On the basis, polysaccharide extraction is performed by fully utilizing the autolysis characteristic of sea cucumber intestines, and a NaCl solution with a specific concentration is key added in the autolysis stage to inhibit polysaccharide degradation, so that the yield of total sugar and sulfated polysaccharide is increased. Furthermore, a synergistic treatment process of alkaline hydrolysis and enzymolysis is adopted, so that polysaccharide components in the sea cucumber intestines are fully released. Experiments show that the obtained polysaccharide can effectively relieve immunosuppression and intestinal barrier injury caused by cyclophosphamide, and the whole immune function of the body is recovered by adjusting intestinal flora and metabolites thereof.

The present invention relates to an aqueous cosmetic composition containing: a sulfated polysaccharide derived from Aphanothece sacrum; a colored pigment or pearl pigment; and an aqueous medium. This aqueous cosmetic composition contains at least 0.03 mass% of sulfated polysaccharide derived from Aphanothece sacrum. The surface of the colored pigment or pearl pigment has not been hydrophilized. The present invention also relates to a cosmetic containing the aqueous cosmetic composition.

The invention relates to the field of biological medicine, and discloses a method for repairing female genital tracts based on marine bioactive substances, which comprises the following steps: S1, providing a composition containing marine bioactive substances, the marine bioactive substances including sea cucumber saponin, oyster polypeptide and fucoidan; s2, preparing the composition into a local gel preparation; s3, the local gel preparation is applied to the female genital tract through vagina or uterine cavity administration so as to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, and the sea cucumber saponin is derived from nitraria tangutorum; the oyster polypeptide is derived from pacific oysters; the fucoidan is derived from sargassum and is sulfated polysaccharide. By combining the sea cucumber saponin, the oyster polypeptide and the fucoidan according to specific proportions (0.5-1.2%, 1-2.5% and 2-4%), the female genital tract repairing effect is remarkably improved, and the composition is superior to single-component gel or existing hyaluronic acid gel.

To provide an oil-in-water emulsion composition that has moderate viscosity, excellent usability, good product stability, and contains a naturally derived thickener. [Solution] An oil-in-water emulsion composition containing a sulfated polysaccharide derived from Suizenji-nori, an oily component, and an aqueous medium; a cosmetic containing the oil-in-water emulsion composition.

The application discloses a preparation method of florfenicol composite medicine and belongs to the technical field of pharmaceutical preparations. First, florfenicol is added into a chitosan solution, and the florfenicol is attached to the chitosan to form a precursor composite. Then, a Spirulina platensis sulfated polysaccharide extract is added into the precursor composite. Due to the binding force between the Spirulina platensis sulfated polysaccharide extract and the chitosan, the composite particles coated with the florfenicol are formed. The Spirulina platensis sulfated polysaccharide extract is located at the periphery of the composite particles, so that the composite particles are hydrophilic and have negative charges. The composite particles coated with the florfenicol are the florfenicol composite medicine. The method reduces the types of medicines used, integrates multiple treatment functions in one medicine, reduces the types of medicines that need to be taken by patients at the same time, and simplifies the treatment scheme. The method has the characteristics of biocompatibility and degradability, improves the water solubility of the florfenicol, and has a very simple reaction process and is suitable for industrial production.

The invention relates to iterative application of compliance development and product upgrading of weight-losing and fat-reducing special medical series food, and belongs to the technical field of special medical purpose formula food (FSMP). According to the series of food, marine active substances (deep sea brown algae sulfated polysaccharide and chitin) and medicinal and edible components (nuciferine and hawthorn flavone) are taken as cores, the bioavailability is improved through a nano-carrier technology and a microcapsule embedding process, and the food conforms to the GB 29922-2013 special medical food standard. The product comprises a total nutrient base material (20-25% of protein and 15-20% of dietary fiber), functional components (8-10% of a marine active extract and 5-8% of a traditional Chinese medicine extract) and a metabolism regulator (3-5% of conjugated linoleic acid). Clinical tests show that after an obese patient takes 400 kcal of the replacement meal every day, the average weight is reduced by 9.5 kg (4.2 kg in a control group) after 12 weeks, and the body fat rate is reduced by 14.7%. The product supports strip iteration (such as powder, tablets and liquid diet) through modular formula design, and fills the market blank of weight-losing and fat-reducing special medical food.

This invention discloses a sustained-release sulfated polysaccharide-based bioblended membrane, its preparation method, and its applications, belonging to the fields of biomedical materials and cosmetics technology. Addressing existing sulfated polysaccharide-protein blend systems, this invention utilizes silk peptides of specific molecular weights as bidirectional interfacial bridges, combined with a sulfated polysaccharide film-forming matrix, hydrolyzed eggshell membrane proteins, and moisturizing and plasticizing components to construct a quaternary synergistic system. This achieves stable and controllable construction of protein self-assembled topological phase-separated microdomains. These continuous network-like topological phase-separated microdomains can form an interpenetrating reinforced network and a molecularly compatible soft interface with the polysaccharide matrix, inhibiting harmful phase separation while comprehensively improving the membrane's mechanical properties, sustained-release controllability, bioactivity, and batch stability. All components are naturally biodegradable and free of chemical cross-linking, making it suitable for applications such as medical dressings and functional skincare patches.