30 results about "Sulfated polysaccharides" patented technology

This invention discloses a compound traditional Chinese medicine powder inhaler for respiratory tract infections and its preparation method, relating to the field of pharmaceutical formulation technology. The compound traditional Chinese medicine powder inhaler for respiratory tract infections is composed of polysaccharide composite gel microspheres, forsythia, scutellaria, honeysuckle, and isatis root. The polysaccharide composite gel microspheres are composed of seaweed sulfated polysaccharide, lentinan, calcium chloride, and curcumin. Seaweed sulfated polysaccharide, lentinan, curcumin, and calcium chloride cross-link to form a three-dimensional network spherical structure, improving the particle morphology and flowability of the micropowder. Furthermore, due to its good hygroscopic and moisturizing properties, it competitively reduces the moisture absorption of the micropowder, preventing aggregation and further improving flowability. In addition, the gel microspheres have excellent adhesion, adhering to the infection site after entering the respiratory tract, reducing expulsion losses due to respiration, maintaining an effective drug concentration at the infection site, and improving therapeutic efficacy.

The present application relates to the field of biological medicine, and discloses a method for repairing female reproductive tract based on marine active substances, comprising the following steps: S1, providing a composition containing marine active substances, wherein the marine active substances comprise sea cucumber saponins, oyster polypeptides and brown alga polysaccharides; S2, formulating the composition into a topical gel preparation; S3, applying the topical gel preparation to the female reproductive tract through vaginal or intrauterine administration to perform endometrial regeneration, scar reduction or inflammation microenvironment improvement, wherein the sea cucumber saponins are derived from Holothuria scabra; the oyster polypeptides are derived from Crassostrea gigas; and the brown alga polysaccharides are derived from Sargassum thunbergii and are sulfated polysaccharides. By combining sea cucumber saponins, oyster polypeptides and brown alga polysaccharides in a specific ratio (0.5-1.2%, 1-2.5%, 2-4%), the repairing effect of the female reproductive tract is significantly improved, which is superior to single-component gel or existing hyaluronic acid gel.

The present invention relates to a two- or three-layer film composition for periodontal use, comprising a hydrophobic polymer outer layer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

This invention provides a method for preparing sulfated polysaccharides suitable for the production of microcapsules. [Solution] The present invention relates to a method for preparing sulfated polysaccharides. A mixture comprising at least one polysaccharide and at least one polar aprotic solvent is prepared in this method. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, and the mixture is then subjected to a temperature treatment so that at least one polysaccharide is converted to at least one sulfated acetate polysaccharide. At least one sulfated acetate polysaccharide is separated from the mixture and converted to a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and methods for producing microcapsules.

The invention relates to a composite in the form of a two-or three-layer film for periodontal use, comprising an outer layer of a hydrophobic polymer and one or two inner layers in the form of electrospun micro / nanofibers based on marine sulfated polysaccharides and calcium.

The application discloses a kind of fibroblast growth factor 2 and mesenchymal cell co-loaded freeze-dried collagen support and its preparation method and application, belong to the technical field of biomedical materials, by adding sulfated polysaccharide to collagen solution, it is formed freeze-dried collagen support containing sulfated polysaccharide by vacuum freeze-drying, it is combined with fibroblast growth factor 2 incubation, obtain the freeze-dried collagen support of loading fibroblast growth factor 2, again mesenchymal cell is inoculated in the freeze-dried collagen support of loading fibroblast growth factor 2, and the freeze-dried collagen support of fibroblast growth factor 2 and mesenchymal cell co-loading is prepared.The support obtained by the application can efficiently combine fibroblast growth factor 2, support the adhesion growth of mesenchymal cell simultaneously, promote mesenchymal cell to migrate to the inside of support, realize the uniform distribution of cell in support, and can promote angiogenesis, provide new and efficient carrier for cell transplantation treatment.

The invention belongs to the technical field of marine polysaccharides, and relates to an anti-hypoxia urechis unicinctus body cavity fluid sulfated polysaccharide as well as a preparation method and application thereof. The weight-average molecular weight of the polysaccharide is 1000-50000 Da, the mass fraction of sulfate radicals is 10.0%-30.0%, and monosaccharide is prepared from galactose, ribose, fucose, glucosamine, mannose and glucose. The preparation method comprises the following steps: inducing controlled degradation of a main chain through high-temperature hot water extraction, carrying out proteolysis deproteinization, carrying out graded ethanol precipitation interception and carrying out anion exchange chromatography purification. The polysaccharide shows a remarkable protective effect in a nerve cell hypoxia simulation model, has excellent free radical scavenging activity, and can be used for preparing medicines, antioxidants, functional foods and the like for preventing or treating hypoxia-related diseases.

The present invention relates to a method for preparing sulfated polysaccharides, in which a mixture is prepared comprising at least one polysaccharide and at least one polar aprotic solvent. At least one sulfating agent, at least one acetylating agent, and at least one peroxydisulfate are added to the mixture, which is then subjected to a temperature treatment, thereby converting the at least one polysaccharide into at least one sulfated acetate polysaccharide. The at least one sulfated acetate polysaccharide is separated from the mixture and converted into a sulfated polysaccharide. The present invention further relates to sulfated polysaccharides that can be prepared using the method according to the present invention. The present invention further relates to microcapsules and a method for producing the microcapsules.

The application discloses a positive electrode material and a preparation method and application thereof. The positive electrode material comprises a core and a coating layer arranged on the surface of the core, and the coating layer contains lithium polysaccharide sulfate. In the application, the core is coated with lithium polysaccharide sulfate, so that the stability of the positive electrode material is improved, especially the stability in a liquid electrolyte, and the electrical performance of the material is improved.

The present invention relates to a biomaterial comprising at least one elastomer matrix and a polysaccharide, and to its use in the reinforcement, reconstruction and / or filling of tissues, preferably in the reinforcement, reconstruction and / or filling of soft and / or epithelial tissue defects, preferably in the repair of skin and / or mucosa.

The invention is directed to a stable composition wash composition. The wash composition comprises a mixture of naturally derived and biodegradable sulfated polysaccharides. The wash composition has a viscosity of 40,000 cps or less, and surprisingly, is free of syneresis, discoloration and malodor, even after being stored at elevated temperatures.

The invention discloses a maltodextrin-included emulsified feed microcapsule and a preparation method thereof, and belongs to the technical field of pig feed. The emulsified feed microcapsule comprises a microcapsule wall material and a core material, and the core material comprises the following raw materials in parts by mass: 12-18 parts of bean pulp with skin, 35-50 parts of corn, 7-13 parts of broken rice, 1-5 parts of protein powder, 4-9 parts of corn bran, 3-6 parts of highland barley powder, 0.1-0.8 part of a compound enzyme preparation, 0.5-1.2 parts of a compound strain liquid, 2-4 parts of vegetable oil, 0.1-0.6 part of an emulsifier, 0.5-1.5 parts of amino acid and 0.2-0.8 part of sulfated polysaccharide; the microcapsule wall material is prepared from the following raw materials in parts by mass: 30 to 50 parts of maltodextrin, 8 to 12 parts of sodium caseinate and 0.5 to 2 parts of pectin-anthocyanin graft. The prepared emulsified feed microcapsule is high in embedding rate, can be quickly dissolved in water, and can reduce the diarrhea rate of piglets.

The invention discloses an anti-HPV (human papillomavirus) underwear laundry detergent based on a sulfated polysaccharide compound system, which is prepared from the following raw materials in percentage by mass: 0.3 to 2 percent of sodium citrate, 6 to 12 percent of fatty alcohol polyoxyethylene ether sodium sulfate, 4 to 10 percent of fatty alcohol polyoxyethylene ether sodium sulfosuccinate, 1.5 to 5 percent of cocamidopropyl betaine, 2 to 6 percent of lauramide propyl hydroxy sulfobetaine and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 2 to 8 percent of alkyl glycoside, 2 to 6 percent of potash soap, 0.1 to 0.3 percent of citric acid, 0.2 to 0.5 percent of protease, 0.8 to 2.5 percent of sulfated polysaccharide, 0.2 to 0.5 percent of silver ion, 0.2 to 0.6 percent of dichloro, 0.1 to 0.2 percent of Kathon, 0.2 to 0.5 percent of essence, 0.5 to 1.5 percent of sodium chloride and the balance of deionized water. According to the invention, a brand-new ternary synergistic antiviral system composed of sulfated polysaccharide, silver ions and diclosan is creatively constructed, and the inactivation rate of the system to pseudoviruses HPV-16 and HPV-18 is increased to gt; compared with a binary combination with the optimal effect, the activity of the compound is improved by more than one order of magnitude, and the qualitative change from partial inhibition to complete removal is realized. The efficient cleaning capacity brought by the synergistic effect can cut off the path of contact transmission of viruses through fabrics such as underwear from the source, and a feasible solution is provided for daily physical prevention of HPV-related infection.

The invention discloses a triple dynamic immune defense compound nutrient as well as a preparation method and application thereof, and relates to the technical field of immunity. The composition consists of red algae sulfated polysaccharide, beta-glucan, an elderberry extract, an echinacea purpurea extract, lactoferrin, nano-selenium, nano-zinc, citric acid and high fructose corn syrup according to a specific ratio. The core of the invention lies in that a triple dynamic immune defense shield theory of'oropharyngeal mucosa barrier (immediate defense)-system immune activation (short-term mobilization)-specific immune regulation (long-term consolidation) 'is proposed and constructed in the field of food for the first time, and through the cooperation of multiple mechanisms of physical blocking, biological inactivation, immune training and long-term regulation, the immunity of the oral pharyngeal mucosa is enhanced. And broad-spectrum prevention and auxiliary intervention on various viruses are realized. All the raw materials with homology of medicine and food and the food nutrition enhancer are adopted, so that the safety is high, and the applicable crowd is wide.

The invention discloses a method for isolating sulfated polysaccharides from Gracilaria tenuistipitata. The method includes collection of sample, sample processing, extraction of sulphated polysaccharides, characterization using spectroscopic techniques and estimation of total carbohydrate and sulphate content to confirm structural and functional properties to yield high-purity sulphated polysaccharides with preserved bioactivity.

This application discloses a complex polysaccharide, its preparation method, and its applications. It discloses both a novel use of sulfated kudzu polysaccharide as a raw material for preparing drugs with anticoagulant effects and a complex polysaccharide comprising sulfated polysaccharide and polysaccharide fragments; wherein the sulfated polysaccharide includes sulfated kudzu polysaccharide and / or sulfated Bletilla striata polysaccharide; and the polysaccharide fragments include glycosaminoglycan fragments. This application modifies the structure of natural polysaccharides to improve their structural properties, preparing and screening complex polysaccharides with anticoagulant activity. The components in the complex polysaccharide work synergistically, significantly enhancing the anticoagulant effect and broadening the application fields of polysaccharides, primarily for the development of anticoagulant drugs and anticoagulant medical devices.

The present invention relates to an aqueous cosmetic composition containing a sulfated polysaccharide derived from Aphanothece sacrum, a colouring pigment or a pearlescent pigment, and an aqueous medium, wherein a content of sulfated polysaccharide derived from Aphanothece sacrum in the aqueous cosmetic composition is 0.03% by mass or more, and the colouring pigment or the pearlescent pigment is not subjected to a hydrophilization treatment on its surface; and a cosmetic product containing the aqueous cosmetic composition.

The invention belongs to the technical field of polysaccharides, and particularly discloses application of sulfated seaweed polysaccharides in preparation of anti-hepatic fibrosis drugs. According to a structural unit of the seaweed sulfated polysaccharide SPW-05-S2, 1, 4-beta-glucuronic acid and 1, 2-alpha-mannose are alternately connected to form a main chain, mannose, xylose, galactose and fucose form branch chains, the branch chains are located on the C-6 site and the C-3 site of the 1, 2-alpha-mannose, and the branch chains are located on the C6 site and the C-3 site of the 1, 2-alpha-mannose. The branches consist of galactose residues, xylose residues, mannose residues and fucose residues. In-vitro experiments prove that the polysaccharide can be used for remarkably inhibiting the expression of fibrosis related proteins (Fibronectin, Collagen I and alpha-smooth muscle actin), and can be used for remarkably inhibiting the expression of the fibrosis related proteins (Fibronectin, Collagen I and alpha-smooth muscle actin). Meanwhile, the surface plasmon resonance technology finds that the polysaccharide can be combined with PI3K protein. Therefore, the polysaccharide has a potential anti-hepatic fibrosis effect and is expected to become a candidate saccharide drug for treating hepatic fibrosis.

The invention discloses a preparation method and application of sea cucumber polysaccharide, and belongs to the field of food and medicine. According to the method, the sea cucumber intestines are used as raw materials, only the sea cucumber intestines are simply washed in the pretreatment stage, on one hand, polysaccharide loss caused by excessive treatment is avoided, on the other hand, a natural grinding medium is provided for subsequent use of bone paste grinding homogenate, and tissue breaking is facilitated; and then the sand grains and the tissue homogenate are separated through standing. On the basis, polysaccharide extraction is performed by fully utilizing the autolysis characteristic of sea cucumber intestines, and a NaCl solution with a specific concentration is key added in the autolysis stage to inhibit polysaccharide degradation, so that the yield of total sugar and sulfated polysaccharide is increased. Furthermore, a synergistic treatment process of alkaline hydrolysis and enzymolysis is adopted, so that polysaccharide components in the sea cucumber intestines are fully released. Experiments show that the obtained polysaccharide can effectively relieve immunosuppression and intestinal barrier injury caused by cyclophosphamide, and the whole immune function of the body is recovered by adjusting intestinal flora and metabolites thereof.

The present invention relates to an aqueous cosmetic composition containing: a sulfated polysaccharide derived from Aphanothece sacrum; a colored pigment or pearl pigment; and an aqueous medium. This aqueous cosmetic composition contains at least 0.03 mass% of sulfated polysaccharide derived from Aphanothece sacrum. The surface of the colored pigment or pearl pigment has not been hydrophilized. The present invention also relates to a cosmetic containing the aqueous cosmetic composition.

To provide an oil-in-water emulsion composition that has moderate viscosity, excellent usability, good product stability, and contains a naturally derived thickener. [Solution] An oil-in-water emulsion composition containing a sulfated polysaccharide derived from Suizenji-nori, an oily component, and an aqueous medium; a cosmetic containing the oil-in-water emulsion composition.

The application discloses a preparation method of florfenicol composite medicine and belongs to the technical field of pharmaceutical preparations. First, florfenicol is added into a chitosan solution, and the florfenicol is attached to the chitosan to form a precursor composite. Then, a Spirulina platensis sulfated polysaccharide extract is added into the precursor composite. Due to the binding force between the Spirulina platensis sulfated polysaccharide extract and the chitosan, the composite particles coated with the florfenicol are formed. The Spirulina platensis sulfated polysaccharide extract is located at the periphery of the composite particles, so that the composite particles are hydrophilic and have negative charges. The composite particles coated with the florfenicol are the florfenicol composite medicine. The method reduces the types of medicines used, integrates multiple treatment functions in one medicine, reduces the types of medicines that need to be taken by patients at the same time, and simplifies the treatment scheme. The method has the characteristics of biocompatibility and degradability, improves the water solubility of the florfenicol, and has a very simple reaction process and is suitable for industrial production.

This invention discloses a sustained-release sulfated polysaccharide-based bioblended membrane, its preparation method, and its applications, belonging to the fields of biomedical materials and cosmetics technology. Addressing existing sulfated polysaccharide-protein blend systems, this invention utilizes silk peptides of specific molecular weights as bidirectional interfacial bridges, combined with a sulfated polysaccharide film-forming matrix, hydrolyzed eggshell membrane proteins, and moisturizing and plasticizing components to construct a quaternary synergistic system. This achieves stable and controllable construction of protein self-assembled topological phase-separated microdomains. These continuous network-like topological phase-separated microdomains can form an interpenetrating reinforced network and a molecularly compatible soft interface with the polysaccharide matrix, inhibiting harmful phase separation while comprehensively improving the membrane's mechanical properties, sustained-release controllability, bioactivity, and batch stability. All components are naturally biodegradable and free of chemical cross-linking, making it suitable for applications such as medical dressings and functional skincare patches.

This invention discloses a method for preparing and applying oxidase-like gold nanoparticles and antibacterial hydrogels. The oxidase-like gold nanoparticles are prepared by the following steps: HAuCl4 solution is added to a sulfated polysaccharide solution and stirred thoroughly. The molar ratio of sulfated polysaccharide to gold ions is 1:10-50. The pH of the solution is adjusted to 2-8, and the solution is heated in a water bath at 90℃-120℃ for 15-30 min. After cooling to room temperature, oxidase-like gold nanoparticles (Fuc-AuNPs) are obtained. This invention uses fucoidan as a stabilizer and reducing agent to synthesize gold nanoparticles in situ on fucoidan. The gold nanoparticles exhibit oxidase-like properties and can catalyze the dissolution of oxygen to generate singlet reactive oxygen species. Fucoidan serves as a template for synthesizing gold nanozymes, and the unique reducing properties of fucoidan are utilized in a one-pot method to prepare the gold nanozymes, avoiding the introduction of reducing agents with safety risks.

The invention presents an environmentally friendly method for producing silver nanopartic1es (AgNP) using sulfated polysaccharides from G. tenuistipitata. This green synthesis approach eliminates the need for harmful chemicals, making it suitable for a wide range of industrial, biomedical, and environmental uses. The resulting AgNPs are stable, uniform in size, and show significant bioactivity. Advanced characterization techniques, such as UV-Vis spectroscopy, FT-IR, FE-SEM, EDX, and XRD, confirm the nanopartic1es' high stability and bioactivity, highlighting their potential for various applications without relying on hazardous substances.

The invention discloses a method for preparing ulva pertusa polysaccharide through co-fermentation of bacillus velezensis SCAU-104 and ulva pertusa powder and application of the ulva pertusa polysaccharide. Compared with the traditional hot water extracted polysaccharide (UPP), the polysaccharide (UBV) obtained by fermentation extraction has the advantages of lower molecular weight, higher sulfate group retention and more optimized structure. And carrying out macroporous resin deproteinization, ultrafiltration desalination and chromatographic purification on the UBV, and separating to obtain the uniform polysaccharide UBV-1. Researches show that UBV mainly comprises rhamnose, galactose and glucuronic acid, and is single molecular weight acidic sulfated polysaccharide. An in-vitro experiment shows that the UBV remarkably promotes RAW264.7 macrophage proliferation and NO and proinflammatory factor release, and the immunocompetence of the UBV is superior to that of UPP. The method disclosed by the invention is green and controllable, and the obtained polysaccharide is high in purity and strong in activity and can be widely applied to development of functional foods, cosmetics, skin care products and immunomodulatory products.

Provided is a hair improver that can impart remarkably satisfactory hair moisture content, combability, and hair luster even with the use of an extremely small amount. This hair improver is characterized by containing a sulfated polysaccharide salt having a sulfate group at the 6-position of at least one sugar unit structure and salted with a monovalent cation. This sulfated polysaccharide may have, for example, any one of the following structural formulae:

[Problem] To provide a novel composition having gut microbiota regulating effect. [Solution] A composition for regulating gut microbiota, the composition being characterized by containing a sulfated polysaccharide that induces gut bacteria interactions in a host and alters the profile of the microbiota so that bacteria contributing to improving the host's health proliferate and pathogens are suppressed. The sulfated polysaccharide is preferably rhamnan sulfate. It is also preferable that the gut microbiota regulation (1) augments at least one selected from the group consisting of Prevotellaceae UCG-001, the Clostridia vadinBB60 group, and Mucispirillum schaedleri and (2) decreases at least one selected from the group consisting of the Rikenellaceae RC9 gut group, ASF356, and Staphylococcus.

The invention discloses a degradable bio-based supramolecular adhesive as well as a preparation method and application thereof, and belongs to the field of bio-based adhesives. Raw materials of the bio-based supramolecular adhesive comprise quaternary ammonium salt polysaccharide and sulfated polysaccharide with opposite charges, and the method comprises the following steps: uniformly mixing aqueous solutions of bio-based polysaccharide with opposite charges, separating precipitates after self-assembly phase separation, and re-dispersing the precipitates in water to obtain a liquid glue type adhesive; and blade-coating the liquid adhesive to form a film, and drying to obtain the solid adhesive tape type adhesive. The bio-based supramolecular adhesive has the bonding strength of 1 MPa or above for base materials such as wood, ceramic, glass and stainless steel, has long-term stability in a wide temperature range of-196 DEG C to 80 DEG C, and has excellent tolerance to strong alkali and strong acid environments. In addition, the raw materials of the adhesive are renewable, the preparation process is simple, convenient and green, the adhesive can be rapidly biodegraded after being used, and the adhesive has the excellent environment-friendly characteristic.

A method of treating a vulnerable atherosclerotic plaque can include identifying the vulnerable atherosclerotic plaque and administering a sulfated polysaccharide, or a pharmaceutically acceptable salt thereof, to a subject in an amount and at a frequency sufficient to stabilize and reverse a vulnerable atherosclerotic plaque.