648 results about "Sea cucumber" patented technology

The invention relates to a sea cucumber growth character recognition and measurement method based on machine vision and a measurement system thereof, and belongs to the field of image processing, and the method comprises the following steps: S1, image acquisition and preprocessing; s2, instance segmentation and morphological feature extraction; s3, measuring the length and width of the sea cucumber; s4, pixel-to-actual size conversion is carried out; s5, constructing a body weight prediction model; and S6, outputting a result. The method has the advantages that the sea cucumber image is obtained by using the high-definition image acquisition technology, the contour information of the sea cucumber is accurately extracted through the instance segmentation algorithm, and the problems of changeable and irregular sea cucumber shapes and the like are effectively solved by combining the optimized image processing technology, so that the measurement precision is remarkably improved. Meanwhile, a machine learning regression model is introduced, the weight of the sea cucumber is predicted based on various morphological characteristics, and the dimensionality and the utilization value of measured data are further enriched.

The invention belongs to the technical field of health-care products, and particularly relates to a fermented composition beneficial to enhancing immunity and a preparation method thereof. The fermentation composition for improving immunity is prepared by taking yeast beta-glucan, an elderberry extract, glucoraphanin, sea cucumber peptide, inulin and a traditional Chinese medicine zymolyte as fermentation raw materials, firstly inoculating bacillus coagulans and staphylococcus xylosus for aerobic fermentation, and then inoculating bifidobacterium longum for anaerobic fermentation, the aerobic fermentation stage and the anaerobic fermentation stage have a synergistic effect, so that the fermentation speed can be increased, the fermentation time can be shortened, and richer nutrient substances can be provided, and therefore, the composition has an excellent effect of enhancing the immunity; the fermentation composition is applied to preparation of capsules helpful for enhancing immunity, is helpful for enhancing human immunity, and can solve the problem that active substances in existing health-care products are difficult to effectively absorb by human bodies, so that the effect of enhancing immunity is influenced.

The invention relates to an application of sea cucumber intestine polysaccharide in preparation of uric acid lowering drugs. The preparation method of the sea cucumber intestine polysaccharide comprises the following steps: performing enzymolysis treatment on sea cucumber intestines by using papain, performing enzyme deactivation, performing centrifugation, and taking supernate; and carrying out graded alcohol precipitation on the supernate, centrifuging, taking precipitate, deproteinizing and freeze-drying. The preparation method is simple, green and environment-friendly. The sea cucumber intestine polysaccharide prepared by the method can effectively inhibit the activity of xanthine oxidase; the sea cucumber intestine polysaccharide has no toxic effect on HK-2 cells. The compound has a uric acid reducing effect on HK-2 hyperuricemia cells.

The invention discloses a preparation method and application of a sea cucumber exosome with an immune cell repairing function, and belongs to the technical field of biomedicine. The method comprises the following steps: feeding sea cucumbers by using a combined method of composite stress and an echinacea extract, extracting sea cucumber cells, and obtaining sea cucumber exosomes through ultracentrifugation; wherein the condition of composite stress is set as follows: the day and night temperature difference is not lower than 3 DEG C, and meanwhile, the dissolved oxygen content of the water body is adjusted to 75-90% of the dissolved oxygen content of the conventional feeding water body. The obtained sea cucumber exosome has a remarkable immune cell repairing function, and can effectively promote proliferation and activity recovery of immune cells, inhibit expression of inflammatory factors and improve the level of anti-inflammatory factors. The sea cucumber exosome prepared by the preparation method disclosed by the invention has an important application prospect in the research and development of immune repair drugs, and can provide a technical support for a novel immune regulation preparation in the field of biomedicine.

The invention relates to the technical field of abalone peptide production, and discloses extraction equipment for extracting natural taurine from sea cucumbers, which solves the problems of function splitting, pollution transfer and low efficiency in the traditional process by integrating three functional modules of countercurrent stirring, in-situ filtration and rotary elution. A reverse stirring part forms shear convection through stirring blades rotating in two directions and a stirring plate, and sea cucumber tissue breaking is accelerated; a dynamic adjusting and filtering mechanism is adopted in the filtering part, filtering modes are switched after stirring, and in-situ separation of the extracting solution and the raw materials is achieved; the elution part drives the cationic resin to be in forced contact with an extracting solution through rotation, and the adsorption efficiency is improved by combining through-channel type resin distribution. The three components cooperatively operate in a single tank, and traditional crushing, extracting, separating and eluting multi-step processes are integrated into a continuous flow. The method has the advantages that the extraction efficiency is improved, the taurine purity is improved, and meanwhile, the material transfer loss and the pollution risk are reduced.

The invention discloses a buoyant raft net cage holothurian culture device and a holothurian culture method. The buoyant raft net cage holothurian culture device comprises a net cage main body, a bait enrichment device and a bait slow release device, the interior of the net cage body is used for containing sea cucumbers. The bait enrichment device is arranged in the net cage main body and comprises at least one deposition structure; the bait slow-release device is arranged in the net cage body and used for controlling the release rate and distribution of bait. According to the novel buoyant raft net cage holothurian culture device and the matched culture method, bait loss can be effectively reduced, the bait utilization rate is increased, and therefore the growth speed and breeding efficiency of holothurian are improved.

The invention discloses an easily-occurring sea cucumber processing control method and system based on oxygen injection synergistic hydrotherapy, relates to the technical field of food processing control, and realizes self-adaption and precise control of a sea cucumber processing process through multi-sensor feedback. The method comprises the following steps: firstly, calling a processing technology parameter vector X of a sea cucumber variety to carry out standardization setting, and calculating the maximum oxygen introduction amount OMAX to carry out pretreatment so as to mildly wake up tissues; and then the real-time water turbidity Trt is monitored until the cleaning threshold TMIN is reached, so that deep cleaning is completed. In the secondary hydrotherapy, the real-time oxygen introduction amount Ort is dynamically adjusted to maintain the target dissolved oxygen concentration DO2 of the secondary hydrotherapy, and the processing environment is stabilized. And monitoring the real-time conductivity Crt of the secondary hydrotherapy solution, and ending the conditioning when the change value C of the real-time conductivity of the secondary hydrotherapy solution meets the requirement, thereby realizing the intelligent judgment of the absorption process. And finally, processing is completed after preset standing time tP, and uniform quality is ensured.

The invention discloses sea cucumber peptide, a preparation method, a composition and application, and relates to the technical field of biology. The sea cucumber peptide has the effect of preventing and / or treating alcoholic liver injury and comprises a first polypeptide, a second polypeptide and a third polypeptide, the amino acid sequence of the first polypeptide is ALKTPDK, the amino acid sequence of the second polypeptide is LEREDGPEVTVI, and the amino acid sequence of the third polypeptide is TGVDNPGHP. The sea cucumber peptide is high in activity, good in biocompatibility, safe and free of toxic and side effects, has good activity of preventing and / or treating alcoholic liver injury, and can be used for preparing products for preventing and / or treating alcoholic liver injury.

The invention relates to a preparation method of small-molecular-weight sea cucumber oligopeptide, the prepared sea cucumber oligopeptide and application, and belongs to the technical field of skin care products. The preparation method of the small-molecular-weight sea cucumber oligopeptide comprises the following steps: preparing sea cucumber fine powder; adding the sea cucumber fine powder into ultrapure water, adding papain and EDTA (Ethylene Diamine Tetraacetic Acid), and carrying out enzymolysis under the assistance of microwaves; adding trypsin and calcium ions, and carrying out enzymolysis under the assistance of microwaves; adding neutral protease and zinc ions, and performing enzymolysis under the assistance of microwaves to obtain final sea cucumber enzymatic hydrolysate; and decolorizing, separating and purifying, and freeze-drying to obtain the powdery small-molecular-weight sea cucumber oligopeptide. According to the preparation method of the small-molecular-weight sea cucumber oligopeptide, microwave heating and enzymolysis reaction are combined, the hydrolysis degree of a peptide chain is regulated and controlled by controlling an enzyme hydrolysis sequence and enzymolysis conditions, the small-molecular-weight sea cucumber oligopeptide with relatively concentrated and moderate molecular weight is prepared, and good biological activity of the sea cucumber oligopeptide is kept.

The invention belongs to the technical field of preparation of biological materials, and particularly discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application of the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The preparation method comprises the following steps: dissolving freeze-dried sea cucumber flower powder in deionized water, adjusting the pH value to be alkaline, heating and stirring, centrifuging, discarding the precipitate, adjusting the pH value to be acidic, centrifuging, collecting the precipitate, and freeze-drying to obtain sea cucumber flower protein powder; preparing a reaction solution, adding simulated gastric juice and simulated intestinal juice, stirring for reaction, inactivating protease, centrifuging, taking supernatant, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; the preparation method comprises the following steps: preparing a solution from sea cucumber, adding FeCl2. 4H2O and ascorbic acid, adjusting the pH value to be acidic, carrying out heating reaction, centrifuging, discarding the supernatant, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-iron nano-carrier. The invention discloses a sea cucumber flower self-assembled polypeptide-iron nano-carrier as well as a preparation method and application thereof. The carrier can promote absorption of an organism to iron, a relatively high iron ion release rate is maintained in an intestinal environment, and the in-vivo bioavailability of iron ions is improved.

The invention relates to the technical field of preparation methods of giant salamander peptide and eucommia ulmoides male flower tablets, in particular to a preparation method of giant salamander peptide and eucommia ulmoides male flower tablets. The giant salamander peptide and eucommia ulmoides male flower tablets comprise the following raw materials in parts by weight: 30-40 parts of giant salamander peptide powder, 20-25 parts of eucommia ulmoides male flowers, 10-15 parts of rape pollen, 10-15 parts of sea cucumber intestine peptide powder, 10-12 parts of a filler, 3-5 parts of an adhesive and 1-3 parts of a lubricant. According to the invention, the eucommia male flower contains geniposidic acid, chlorogenic acid, aucubin lignin, iridoid and phenylpropanoid natural active nutrient substances, flavonoid compounds, polysaccharide and other bioactive substances in the rape pollen, polysaccharide and peptide components in the sea cucumber intestine peptide powder, and the like. The andrias davidianus peptide powder is added into the andrias davidianus peptide powder, the andrias davidianus peptide powder cooperates with antioxidant peptide and immunomodulatory peptide in the andrias davidianus peptide powder to jointly form a rich bioactive substance library, and the components regulate the physiological functions of the human body from different angles, provide comprehensive nutrition support for the body and improve the fatigue resistance of the human body.

The invention discloses a sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity and a preparation method and application thereof, belongs to the technical field of functional protein peptides, and particularly relates to a preparation method of the sea cucumber flower self-assembled polypeptide-selenium nano-carrier with antioxidant activity, which comprises the following steps: heating a sea cucumber flower protein solution; the preparation method comprises the following steps: mixing sea cucumber with simulated gastric juice, reacting for 30-150 minutes, then adding simulated intestinal juice, reacting for 20-120 minutes, carrying out enzyme deactivation treatment, centrifuging, taking supernate, and freeze-drying to obtain sea cucumber flower self-assembled polypeptide; and mixing the sea cucumber flower self-assembled polypeptide with deionized water to prepare a sea cucumber flower self-assembled polypeptide solution, mixing the sea cucumber flower self-assembled polypeptide solution with a sodium selenite solution and a phosphate buffer solution, reacting for 20-60 minutes, washing with an ethanol solution, centrifugally collecting precipitate, and freeze-drying to obtain the sea cucumber flower self-assembled polypeptide-selenium nano-carrier. The sea cucumber flower self-assembled polypeptide-selenium nano-carrier prepared by the invention has good antioxidant activity and potential of effectively delivering selenium to an organism.

The invention discloses an active exosome stent coating based on traditional Chinese medicine enhanced secretion promotion and a preparation method and application thereof, and belongs to the technical field of biological medicine and interventional instruments. The stent coating comprises exosomes, wherein the exosomes comprise myocardial cell active exosomes and human mesenchymal stem cell active exosomes which are intensified and secreted by traditional Chinese medicines; wherein the traditional Chinese medicines comprise placenta extract, pilose antler extract, sheep myocardial peptide, sea cucumber peptide, lycium ruthenicum peptide, cnidium lactone, curculigo orchioides extract and morinda officinalis extract; the intervention concentration of each component added into cells is 2-50 [mu] g / mL; the light-cured gel matrix is prepared from methacrylated gelatin, a photoinitiator and polyether 127; tacrolimus; the final concentration of the exosome is 1 * 10 < 9 >-12 * 10 < 9 > particles / mL, and the final concentration of the tacrolimus is 5-25 mu g / mL. The coating can be coated on the surface of the poly-L-lactic acid degradable stent to prepare the degradable stent, and has obvious vascular repair promoting capability.

The invention discloses scallion braised sea cucumber processing and sampling equipment, and relates to the technical field of sampling, the scallion braised sea cucumber processing and sampling equipment comprises a fixed bottom table, the fixed bottom table is provided with a height control mechanism, the height control mechanism is connected with a lifting round block, the lifting round block is provided with a rotary displacement ring mechanism, and the outer side of the rotary displacement ring mechanism is provided with a mounting ring mechanism; the mounting ring mechanism is provided with a plurality of sampling assemblies, each sampling assembly comprises a deflection mounting mechanism, a sampling barrel mechanism and a liquid separation mechanism, the rotary displacement ring mechanism is provided with a driving ring mechanism, and a lifting circular block is fixedly connected with a deflection pressing plate mechanism. And the positions of the sampling assemblies can be adjusted by rotating the displacement ring mechanism, and the sampling assemblies meeting the required number can be mounted through the mounting ring mechanism, so that the material extraction efficiency is improved.

The invention provides a sea cucumber culture fishing underwater robot cooperative work system, and the system comprises a fishing boat module which is used as a water surface control center and provides calculation, communication and power support; the plurality of underwater robot modules are used for executing underwater autonomous navigation, target identification, sea cucumber fishing and data acquisition tasks; the umbilical cable collecting and releasing system module is used for collecting, releasing and managing an umbilical cable for connecting the fishing boat and the underwater robot; a cooperative control system module; a balance adjustment system module; according to the invention, through unified task allocation and dynamic path planning of a plurality of underwater robots, by using an improved A * algorithm and a UWB positioning technology, the plurality of robots can efficiently cover an operation area without omission, and the distance is calculated in real time to trigger an obstacle avoidance program, so that the obstacle avoidance efficiency is improved. The problems of low efficiency, repeated fishing, region omission, high collision risk and the like caused by a traditional manual region division or simple wireless communication cooperation mode are solved.

The invention belongs to the technical field of medicine, and discloses a sea cucumber and ganoderma lucidum immune steady-state compound and a composite enzymatic hydrolysis targeted liposome co-delivery preparation process thereof.The sea cucumber and ganoderma lucidum immune steady-state compound is composed of sea cucumber, ganoderma lucidum, American ginseng, dried oyster meat, fructus lycii and perilla leaves; the ganoderma triterpenes release free polysaccharides and are combined with a liposome intestinal targeted delivery system, so that the absorption rate of the polysaccharides is greatly improved to 18-22% from 5% in the traditional process, the ganoderma triterpenes are emulsified and entrapped through a liposome double-layer membrane, and meanwhile, the permeation promotion effect of perillaldehyde in the perilla leaf volatile oil is supplemented, so that the transmembrane transport efficiency is remarkably enhanced, the absorption rate is improved to 12-15% from 2%, and the bioavailability is improved. The zinc element decomposes oyster zinc protein into free zinc ions through a composite enzymolysis technology, and the free zinc ions and vitamin C form a stable chelate, so that the antagonism of intestinal tracts is reduced, the zinc absorption rate is increased from 20% to 45-50%, and a solid foundation is laid for fully playing a compound immune regulation effect.

The invention belongs to the technical field of aquaculture feed processing, and particularly relates to a processing technology of a sea cucumber intermediate culture feed. The sea cucumber intermediate breeding feed comprises fish meal, soybean protein isolate, seaweed meal, fermented soybean meal, multivitamins, a multivitamin premix and mineral salt. The processing technology comprises the following steps: firstly carrying out crushing pretreatment on the raw materials, then mixing the crushed raw materials, carrying out hardening and tempering, then carrying out twin-screw extrusion puffing to form carrier particles, carrying out low-temperature drying, then carrying out high-pressure atomization spraying technology to load the fish oil phospholipid complex, carrying out three-stage variable-temperature drying treatment, and finally carrying out cooling screening. The sea cucumber intermediate breeding feed processed by the method can be used for breeding in a transition stage from young sea cucumbers to young sea cucumbers, the survival rate of the young sea cucumbers in the breeding process is increased, and the sea cucumber intermediate breeding feed has the advantages of high nutrient retention rate and slow dissolution loss characteristic; in addition, the invention has the advantage of improving the order of micropores in the particles and the compactness of the surface layer so as to improve the physical stability of the sea cucumber intermediate culture feed.

The invention discloses a holothurian culture feed additive and a preparation method thereof, and belongs to the technical field of aquaculture. According to the technical scheme, the holothurian culture feed additive comprises the following components in percentage by mass: 45%-55% of fish meal, 2%-3% of butyric acid bacteria, 25%-30% of compound probiotics, 2%-4% of a Chinese herbal medicine extract, 8%-12% of a fermentation substrate, 10%-15% of seaweed meal, 0.5%-1% of vitamin E, 0.5%-1% of selenium yeast and the balance of a carrier, the compound probiotics are composed of lactic acid bacteria, bacillus and photosynthetic bacteria according to the mass ratio of 2: 1: 1; the Chinese herbal medicine extract is a mixture of astragalus polysaccharide and an asarum extract in a mass ratio of 3: 1; through the synergistic effect of the fish meal, the compound probiotics, the Chinese herbal medicine extract and other components, nutrition balance and intestinal flora regulation and control are achieved, the problems of slow growth, intestinal diseases and water quality pollution caused by traditional feed are effectively solved, and the sea cucumber feed has the advantages that the survival rate of sea cucumbers is increased, and the culture benefits are increased.

A peptide composition for improving tear stains of pets belongs to the field of pet health, is used for improving tear stains of pets, and is characterized by comprising 20-30 parts of sea cucumber peptide, 5-10 parts of casein phosphopeptides, 10-20 parts of soybean peptide, 20-30 parts of corn oligopeptide, 10-20 parts of wheat oligopeptide and 10-20 parts of mussel peptide, the amino acid sequence of common mussel peptide is His-Gly-Ala-Asp-Gly-Val-Pro-Pro-Phe, and the amino acid sequence of the common mussel peptide is His-Gly-Ala-Asp-Gly-Val-Pro-Pro-Phe. The amino acid sequence of the perna viridis peptide is Asp-Ser-Ser-Leu-Pro-Pro-Ser-Arg-Pro-Thr, and the perna viridis peptide has the effects of effectively improving the metabolism of ferriporphyrin, inhibiting the activity of saccharomycetes and reducing the formation of tear stains of pets.

The invention relates to the technical field of preparation of stimuli-responsive hydrogel, in particular to sea cucumber ion skin imitating double-dynamic topology hydrogel as well as a preparation method and application of the sea cucumber ion skin imitating double-dynamic topology hydrogel. The thermo-sensitive poly (N-isopropylacrylamide) hydrogel is used as a continuous matrix and is used for simulating the dynamic adaptability of sea cucumber skin; and the ionic conductive microgel is used as a rigid dispersion phase and is used for simulating a collagenous fiber network of a connective tissue layer of the sea cucumber. The microgel is dispersed in the poly (N-isopropylacrylamide) hydrogel and is physically entangled with the poly (N-isopropylacrylamide) hydrogel to form a cross-linking point, so that a dynamic network of'rigid node-flexible matrix 'is constructed. The dynamic network structure endows the double-dynamic topological hydrogel with force and heat double toughening properties and ultralow mechanical hysteresis, so that the double-dynamic topological hydrogel has excellent elasticity, fatigue resistance, low hysteresis and strain rate insensitivity, and further shows wide application prospects in the fields of flexible sensing and wearable equipment.

The invention provides a multi-parameter combined control method and system for key nodes in a sea cucumber processing process, and relates to the technical field of automatic control. Executing drying control in a first drying stage according to preset parameters, monitoring to obtain a first sea cucumber image set, extracting a first real-time drying feature, and then calculating a drying feature deviation; and setting a second-stage drying target according to the second-stage drying index and the drying characteristic deviation, performing drying parameter optimization based on the target, determining an optimal second drying parameter to execute second-stage drying control, and performing iterative deviation analysis and drying parameter optimization until a plurality of drying stages are completed. The technical problems that in the prior art, due to the fact that the sea cucumber state cannot be monitored in real time and drying parameters cannot be dynamically adjusted, drying deviation accumulation is caused, and drying uniformity is poor are solved, and the technical effect of improving the overall drying uniformity and quality stability of sea cucumbers is achieved.

The invention relates to the technical field of active peptides, and discloses a whitening and anti-wrinkle protein active peptide composition as well as a preparation method and application thereof. The whitening and anti-wrinkle protein active peptide composition is prepared from the following raw materials in parts by weight: 10 to 15 parts of elastin peptide, 11 to 14 parts of fish collagen peptide, 8 to 10 parts of fish maw small-molecule active peptide, 5 to 10 parts of cubilose peptide, 5 to 10 parts of sea cucumber peptide, 2 to 6 parts of Chinese fevervine herb active peptide, 1 to 3 parts of zingiber corianum active peptide and 1 to 5 parts of lycopene. According to the whitening and anti-wrinkle protein active peptide composition and the preparation method and application thereof, small-molecule active peptide in the prepared protein active peptide composition is beneficial to absorption of dermal cells, and meanwhile, through the synergistic effect of multiple active ingredients, the whitening and anti-wrinkle effects are effectively achieved, the skin quality is improved, and aging is delayed.

The invention discloses a ceramide composition capable of promoting cell repair and a preparation method and application thereof, and belongs to the technical field of foods.The ceramide composition is prepared from, by weight, 0.5-2 parts of rice bran oil powder, 0.5-2 parts of salvia officinalis extract and 5-32 parts of bioactive peptide. The bioactive peptides comprise fish collagen peptide, cubilose peptide and sea cucumber peptide, and the weight ratio of the fish collagen peptide to the cubilose peptide to the sea cucumber peptide is (30-55): 1: (1-10). Through the synergistic effect of the rice bran oil powder, the salvia officinalis extract and the bioactive peptide, cell repair is promoted jointly, and efficient repair of a skin barrier is achieved.

This invention provides an automatic feeder for sea cucumber seedlings, comprising an integrated feed mixing and dispensing device. The integrated feed mixing and dispensing device includes a mixing tank, a mixing tank cover, an electric cylinder, and a feed mixing and dispensing mechanism. The mixing tank is a cylindrical structure with its axis perpendicular to the horizontal plane and closed at the top and open at the bottom. A feed inlet is located at the top of the mixing tank. The mixing tank cover is located directly below the mixing tank and is detachably fitted onto the opening at the bottom of the mixing tank. One end of the electric cylinder is mounted on the mixing tank body, and the other end is mounted on the mixing tank cover. The feed mixing and dispensing mechanism includes a pulsator motor and a pulsator. The pulsator motor is mounted on the mixing tank cover, and its output shaft extends upward along the axis of the mixing tank body. The pulsator is coaxially mounted on the output shaft of the pulsator motor and located directly above the mixing tank cover. Compared to existing technologies, this invention is smaller, lighter, and more flexible.

The invention discloses a PtTe-Co (OH) 2 core-shell catalyst as well as a preparation method and application thereof, and belongs to the technical field of electrolyzed water catalysts. The morphology of the PtTe-coated Co (OH) 2 core-shell catalyst is in a sea cucumber-like shape, sea cucumber-like PtTe is used as a core, and amorphous Co (OH) 2 is used as a shell. The preparation method comprises the following steps: preparing sea cucumber-like PtTe by adopting a one-step wet chemical reduction method, and covering the surface of the PtTe with an amorphous Co (OH) 2 nano-sheet by adopting an in-situ growth method, so as to prepare the core-shell catalyst. The prepared PtTe-Co (OH) 2 core-shell catalyst has an excellent bifunctional characteristic, can drive an electrolyzed water reaction, and is simple in process, low in cost, safe in process, small in pollution and suitable for large-scale industrial production.

The invention belongs to the technical field of biology, and discloses a bioactive peptide which is a micromolecular anti-tumor bioactive peptide derived from sea cucumber, and the amino acid sequence of the bioactive peptide is FNPDTFD. Sephadex G-15 gel chromatography and mass spectrometry technologies are used for separating, purifying and structurally identifying the sea cucumber flower enzymolysis peptide, so that the small molecule peptide with a potential anti-tumor effect is obtained. A cell viability experiment verifies that the small molecule peptide can selectively inhibit the proliferation of EGFR mutant non-small cell lung cancer cells. Besides, molecular docking and protein immunoblotting results show that the peptide can be combined with EGFR mutant protein, and the activation of a downstream Akt / mTOR signal channel is inhibited by targeting the EGFR mutant protein, so that the biological activity of resisting the non-small cell lung cancer is exerted. The bioactive peptide not only has the potential of being developed into a new generation of EGFR targeting antitumor drugs, but also has wide application prospects in the field of functional health food. The preparation process is simple, and is suitable for industrial production and market popularization and application.

The invention provides an anti-aging composition containing sea cucumber peptide and a preparation method of the anti-aging composition, and belongs to the technical field of cosmetics. Mixing the sea cucumber peptide compound, the fermented smallanthus sonchifolius extract, the grape seed extract and the clam peptide at 23-25 DEG C for 10-15 minutes to obtain a mixture; the preparation method comprises the following steps: dispersing xanthan gum and sodium carboxymethyl cellulose in purified water at 85-90 DEG C, and stirring and mixing for 20-30 minutes to obtain a mixed system A; mixing the mixed system A, sodium hyaluronate, butanediol, hydroxyethyl urea, stearyl alcohol polyether-21 and glycosylglycerol at 50-55 DEG C for 10-15 minutes to obtain a mixed system B; and mixing the mixed system B and the mixture at 40-45 DEG C for 20-30 minutes to obtain the anti-aging composition. The sea cucumber peptide and the clam peptide jointly stimulate collagen synthesis through the synergistic effect, and good anti-aging and moisturizing effects are achieved through the synergistic effect of multiple components.

The invention discloses an immunity-enhancing sea cucumber peptide raw material processing device and a processing technology thereof, and relates to the technical field of raw material processing, the immunity-enhancing sea cucumber peptide raw material processing device comprises a bottom plate, the top position of the bottom plate is fixedly connected with a sliding rail, the sliding rail is slidably connected with a material collecting box, the bottom plate is fixedly connected with a frame, and the bottom position of the frame is provided with a processing box; the device further comprises a discharging assembly, a partition assembly and a smashing assembly, the discharging assembly is arranged at the top of the frame and used for feeding raw materials, the partition assembly is arranged on one side of the frame and used in cooperation with the discharging assembly, and the smashing assembly is arranged on the processing box and used for processing the raw materials. The device is reasonable in structure, raw materials in the storage cylinder can be discharged through cooperative use of the discharging assembly and the partition assembly, and finally the raw materials in the processing box are processed through the crushing assembly.

The invention discloses a method for extracting nutrient substances from sea cucumber processing wastewater and application, and belongs to the technical field of sea cucumber processing wastewater extraction. According to the method, the sea cucumber processing wastewater is used as a raw material, nutrient substances in the wastewater are extracted, the processing wastewater is pretreated by adopting an air floatation-microfiltration coupling technology, suspended solids and grease in the wastewater can be effectively removed, and heat-sensitive substances are reserved; meanwhile, a pH response type flocculating agent is adopted for removing heavy metal in a high-selectivity mode, meanwhile, loss of nutrient substances including protein, polysaccharide and saponin is avoided, after pretreatment is completed, a staged enzymolysis technology, a membrane separation-adsorption combined technology, a vacuum thin film evaporation technology and a programmed cooling crystallization technology are cooperated, protein, polysaccharide and saponin can be effectively separated and extracted, and the quality of the product is improved. The recovery rate, the purity and the product performance of each nutrient substance are remarkably improved, and technical support is provided for reutilization of nutrient components in sea cucumber processing wastewater.

The invention provides a ginseng and ginseng peptide collagen drink for consolidating basis, reinforcing vital essence and resisting aging as well as a preparation method and application thereof, relates to the technical field of health-care drinks, and belongs to the IPC classification number A23L2. The ginseng and ginseng peptide collagen drink comprises a ginseng extract, a protein peptide compound, a tremella extract, a Chinese wolfberry fruit extract, an astragalus membranaceus extract, fruit and vegetable enzymes, kale powder and PQQ disodium salt. The protein peptide compound is composed of sea cucumber peptide, bone collagen peptide, ovalbumin peptide, fish scale peptide and cubilose peptide. The ginseng extract and the astragalus extract can tonify qi and blood, the wolfberry extract and the tremella extract can nourish yin, and the sea cucumber peptide and the fish scale peptide can tonify kidney, tonify qi, blood, yin and yang and consolidate basis; the protein peptide compound supplements collagen and amino acid required by a human body and delays structural aging; the PQQ disodium salt can reverse mitochondrial aging, and the fruit and vegetable enzyme and the kale powder can regulate metabolic balance. Animal experiments show that the double-ginseng peptide collagen drink has the effects of resisting oxidation, improving immunity and resisting aging.