The invention discloses a wastewater treatment agent for aquaculture. The wastewater treatment agent contains an ingredient A, an ingredient B, an ingredient C and an ingredient D, wherein the ingredient A is at least one of dicalcium phosphate, sodium dihydrogen phosphate, sodium selenite and magnesium sulfate; the ingredient B is at least one of DL-methionine, a L-lysine salt, tryptophane, threonine, betaine, astaxanthin, glucan, peptidoglycan, yeast and lipopolysaccharide; the ingredient C is at least one of sodium humate powder, sodium thiosulfate powder and aluminum potassium sulfate powder; and the ingredient D is at least one of glycyrrhiza uralensis, mung bean flour, acanthopanax bark, codonopsis pilosula, dried tangerine peel, Chuanxiong rhizome, gardenia, gypsum, dittany bark, folium isatidis, cortex phellodendri, radix isatidis, eupatorium fortunei and radix bupleuri. According to the wastewater treatment agent for aquaculture, through promoting the growth of plankton in culture water, the water treatment rate is accelerated, the self-purification ability of the water is improved, the improvement on water environment is promoted, influence on fishes in the water cannot be caused, and secondary pollution cannot be caused.