The invention provides an iron and steel complex comprehensive wastewater treatment device and process. The device comprises a coagulation unit, a biochemical treatment unit, a filter unit and an ozone catalytic oxidation unit. The biochemical treatment unit comprises a nitrification biofilter and a denitrification biofilter. The coagulation unit, the denitrification biofilter, the nitrification biofilter, the filter unit and the ozone catalytic oxidation unit are connected in order; or, the coagulation unit, the ozone catalytic oxidation unit, the denitrification biofilter, the nitrification biofilter and the filter unit are connected in order; or, the coagulation unit, the nitrification biofilter, the denitrification biofilter, the filter unit and the ozone catalytic oxidation unit are connected in order. The device can remove COD and ammonia nitrogen from wastewater synchronously at low cost, has the advantages of high treatment efficiency, good stability, strong impact resistance ability and simple operation, can flexibly selects the connection form of the treatment units according to the water quality condition, can realize the whole course flow by gravity, lowers energy consumption, and is conducive to project promotion.