The invention provides a compound
disinfectant for preventing and treating
aquaculture virus diseases and a preparation method thereof. The composite
disinfectant is prepared by introducing
polyhexamethylene guanidine or a salt thereof, a
quaternary ammonium salt compound,
metal nanoparticles and an auxiliary agent into a water
system as main raw materials, and is prepared by the following steps: adding a
quaternary ammonium salt compound solution and a penetrating agent into a
polyhexamethylene guanidine or
salt solution thereof, and uniformly stirring and mixing to obtain a
mixed solution A; slowly dropwise adding the
metal nanoparticle dispersion liquid into the
mixed solution A, starting ultrasonic treatment at the same time, and uniformly stirring and mixing to obtain a
mixed solution B; dropwise adding the pH
regulator solution into the mixed solution B, regulating the pH, adding the
preservative solution, supplementing water, uniformly mixing, standing and curing to obtain the composite
disinfectant. The compound disinfectant aims at achieving synergistic interaction, finally achieves the comprehensive prevention and treatment effects of being efficient, low in
toxicity, broad in spectrum and not prone to inducing
drug resistance, and particularly achieves efficient and safe prevention and control on fish,
shrimp and crab
virus diseases so as to meet the urgent requirement for healthy
aquaculture.