2627 results about "Antibacterial activity" patented technology

Provided are a small-molecule antibacterial polypeptide, and a preparation method therefor and a use thereof. The antibacterial peptide provided has stronger antibacterial activity than most other derivative polypeptides and antibacterial polypeptides disclosed in existing reports. Multiple strains known for drug resistance are used to carry out bactericidal activity evaluation. The result shows that the antibacterial peptide provided has broad-spectrum antibacterial activity against drug-resistant strains, achieves more comprehensive antibacterial effects, and has a wider range of indications.

The invention provides a broad-spectrum antibacterial peptide, an antibacterial agent and application, and belongs to the technical field of biological medicine. The invention provides a broad-spectrum antibacterial peptide. The broad-spectrum antibacterial peptide comprises an amino acid sequence as shown in SEQ ID No. 1. The minimum inhibitory concentration of the antibacterial peptide to gram-positive bacteria, gram-negative bacteria and fungi proves that the antibacterial peptide has obvious antibacterial activity to the gram-positive bacteria, the gram-negative bacteria and the fungi. The invention also verifies the minimum inhibitory concentration of the antibacterial peptide to clinical drug-resistant bacteria. The cytotoxicity of the SL-12 disclosed by the invention is relatively weak, the SL-12 only shows obvious cytotoxicity at 200 [mu] g / ml, and the minimum inhibitory concentration of the SL-12 is 6.25-12.5 [mu] g / ml; the SL-12 has no obvious hemolytic activity when the concentration is 100 [mu] g / ml or lower, and is high in safety.

The invention relates to an antibacterial peptide generation method and device based on a generative model and computer equipment, and relates to the technical field of artificial intelligence and bioinformatics. Predicting the novel antibacterial peptide on the basis of the existing antibacterial peptide sequence by using a pre-trained generative model to obtain a predicted sequence; inputting the prediction sequence into a pre-trained antibacterial peptide classifier, and judging whether the prediction sequence has antibacterial activity or not; the antibacterial peptide classifier is obtained by training based on an antibacterial peptide tag set and a non-antibacterial peptide sequence tag set; and outputting the prediction sequence with the antibacterial activity as a final target antibacterial peptide sequence, so that the problem of low antibacterial peptide design generation efficiency is solved, de novo generation and judgment of the antibacterial peptide can be realized by virtue of a generative model and a classifier, and the generation efficiency and accuracy are improved.

The present disclosure relates to the technical field of antibacterial drugs, and specifically relates to a micromolecular antibacterial polypeptide, and a preparation method therefor and the use thereof. The antibacterial peptide provided in the present disclosure has a stronger antibacterial activity compared with most other derived polypeptides and the antibacterial polypeptides disclosed in the existing reports. Bactericidal activity evaluation is carried out by using a plurality of strains known to have drug resistance, and the results show that the antibacterial peptide provided in the present disclosure has broad-spectrum antibacterial activity against drug-resistant strains and more comprehensive antibacterial effects, and allows for wider indications.

The invention discloses a BamA-targeting antibacterial peptide as well as a preparation method and application thereof, and is characterized in that amino acids in a sequence are all D-type amino acids, and the amino acid sequence is as follows: w-r-r-w-r-r-p-w-k-r (dTrp-dArg-dArg-dTrp-dArg-dArg-dPro-dTrp-dLys-dArg). The antibacterial peptide provided by the invention has good antibacterial activity, can be synthesized by adopting an Fmoc solid-phase chemical method, is low in preparation difficulty, and has high affinity with target protein BamA.

The invention relates to the technical field of wood corrosion prevention and corrosion resistance treatment, in particular to a preparation process of a coating for improving the antibacterial and corrosion-resistant performance of wood. In order to improve the antibacterial and corrosion-resistant capabilities of the prepared coating, a corrosion-resistant antibacterial agent is prepared and added into the raw materials of the coating, and quaternary ammonium salt, guanidyl and other group structures are introduced into the corrosion-resistant antibacterial agent, so that the antibacterial performance on microorganisms such as fungi is realized; the introduction of fluorine can effectively improve the hydrophobicity of a coating of the paint and reduce the influence of water vapor on antibacterial components in the coating, and the introduction of allyl can enable the corrosion-resistant antibacterial agent to react with butyl acrylate and other raw materials under the action of an initiator to achieve the cross-linking ability, so that the loss of the corrosion-resistant antibacterial agent is effectively avoided, and the service life of the coating is prolonged. The antibacterial activity is kept for a long time.

The invention provides a streptomyces, which is named as Streptomyces sp. And is registered and preserved in Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC No: 65917. The invention also provides a fermentation broth of the streptomyces, and an ethanol extract and a crude extract of the fermentation broth. The novel streptomyces, the crude extract thereof and the like have broad-spectrum antibacterial activity, have a good antagonistic effect on various pathogenic bacteria such as banana long leaf spot germs and banana colletotrichum gloeosporioides, can enable hyphae of the banana colletotrichum gloeosporioides to shrink, deform and break, inhibit spore germination of the banana colletotrichum gloeosporioides, and have a good anti-bacterial effect on the banana colletotrichum gloeosporioides. According to the present invention, with the application of the bacterial strain, the colletotrichum gloeosporioides spores are shrunk and broken, the growth of the colletotrichum gloeosporioides is inhibited, the peroxidase activity, the polyperoxidase activity, the CAT activity and the like in the banana peel can be improved, and the bacterial strain is the potential biological agent for the prevention and control of the colletotrichum gloeosporioides diseases, and has wide development space and good development and application prospects.

The invention discloses an antibacterial peptide SAMP4 or a derivative thereof, a pharmaceutical composition and application, and belongs to the technical field of biology, the amino acid sequence of the antibacterial peptide SAMP4 is as shown in SEQ ID NO: 1, and the antibacterial peptide SAMP4 has a broad-spectrum antibacterial effect and can be used for preparing antibacterial peptide SAMP4. The compound has a strong bacteriostatic effect on various gram-positive bacteria such as staphylococcus aureus, enterococcus and streptococcus and various gram-negative bacteria such as escherichia coli, acinetobacter baumannii and pseudomonas aeruginosa, and is strong in antibacterial activity, wide in antibacterial spectrum and low in toxicity. The invention also provides a derivative and a salt of the antibacterial peptide SAMP4 and application of the antibacterial peptide SAMP4 and the derivative and the salt of the antibacterial peptide SAMP4 to research, development and preparation of various antibacterial products or / and antibacterial drugs and treatment of bacterial infectious diseases, and the antibacterial peptide SAMP4 and the derivative and the salt of the antibacterial peptide SAMP4 are remarkable in advantages and wide in application prospect.

According to the preparation method of the Huangshan pine needle polyphenol and the acne-removing and inflammation-diminishing essence, the Huangshan pine needle polyphenol is prepared by adopting a microbial solid fermentation method, release of soluble polyphenol substances in Huangshan pine needles is remarkably promoted, and compared with an unfermented group, the polyphenol content of pine needles reaches up to 146.32 + / -2.53 mg / g and is increased by 1.89 times. The pine needle polyphenol component is prepared by adopting ultrasonic-assisted deep eutectic solvent extraction, membrane filtration and separation and purification technologies, the method has the advantages of short extraction time, low extraction temperature, environmental friendliness and the like, the structural integrity of pine needle polyphenol is maintained to the greatest extent, and the antibacterial activity of polyphenol is remarkably improved. The acne-removing and inflammation-diminishing essence containing the Huangshan pine needle polyphenol is soft in formula and high in safety, has remarkable dual effects of moisturizing and acne removing, can effectively inhibit skin inflammation, promote repair of acne skin, maintain the health state of the skin and meet the requirements of people, and can be widely applied to the field of skin care products.

The invention discloses a gynecological antibacterial gel containing a carbomer component, and belongs to the technical field of gynecological nursing materials. The gel is prepared from 0.5 to 5 percent of plant extract microcapsules, 0.5 to 3 percent of carbomer, 2 to 10 percent of glycerol, 0.1 to 1.5 percent of triethanol and the balance of purified water. The plant extract microcapsule is prepared by compounding methacrylated silk fibroin and a caffeic acid hyaluronic acid graft, has temperature responsiveness, can improve the adhesive force on the surface of vaginal mucosa, and realizes slow release of the plant extract; the caffeic acid catechol hydroxyl is chelated with silver ions, a nano-silver monodisperse layer is formed on the surface of the microcapsule, and the antibacterial activity is improved. The composite plant extract can inhibit bacteria, repair mucous membranes and maintain the acidic microenvironment of the vagina. When the gel is prepared, the problem that the swelling efficiency of carbomer is low is solved through glycerol pre-grinding, and triethanolamine is added in three times to form a gradient cross-linked network. The problems that traditional gel is unstable in viscosity, poor in mucous membrane adhesiveness and prone to damaging vagina micro-ecology are solved, the antibacterial effect is good, and preservation is stable.

The invention discloses application of GGTI298 in prevention and control of rice blast, and belongs to the technical field of rice blast prevention and control. According to the technical scheme, the novel medical application of the GGTI298 is disclosed, and the GGTI298 has good antibacterial activity on magnaporthe oryzae and can inhibit conidia germination and appressorium formation of the magnaporthe oryzae so as to influence pathogenicity. The GGTI298 has a prospect of preventing and treating magnaporthe oryzae infection, and a reference basis is provided for development of antibacterial drugs based on a GGTI298 pilot structure.

The invention provides bacillus velezensis NR10, and the preservation number of the bacillus velezensis NR10 is CGMCC (China General Microbiological Culture Collection Center) NO.31771. The bacillus velezensis NR10 is a strawberry endophyte, has good bacteriostatic activity, has good antagonistic action on botrytis cinerea, fusarium oxysporum, colletotrichum gloeosporioides, colletotrichum oxysporum, trichoderma harzianum, trichoderma longibrachiatum and the like, is a potential biological preparation for preventing and treating strawberry diseases and the like, and has broad application prospects. And the bacteriostatic action of the bacillus velezensis NR10 has thermal stability. In addition, the bacillus velezensis also has good capacities of producing siderophores, fixing nitrogen and dissolving potassium, producing protease and cellulase and the like. The bacillus velezensis NR10 provided by the invention has wider-spectrum disease resistance, wide development space and good development and application prospects.

The invention belongs to the field of microorganisms, and relates to a bacillus velezensis BLS-27 and a fungicide and application thereof, the bacillus velezensis BLS-27 is preserved in China General Microbiological Culture Collection Center on October 21, 2024, the preservation number is CGMCC No.32274, and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The strain BLS-27 has an inhibition effect on wild jujube anthracnose pathogenic bacteria, can effectively inhibit various plant disease pathogenic bacteria, shows broad-spectrum antibacterial activity, is environment-friendly and can be widely applied to plant disease control.

The invention discloses preparation and application of a block cationic copolymer / quaternary ammonium salt chitosan-based composite hydrogel. The preparation method comprises the following steps: reacting a sodium alginate solution with a NaIO4 solution at room temperature in a dark place to obtain an oxidized sodium alginate solution; adding ethylene glycol into the oxidized sodium alginate solution, reacting, concentrating, dialyzing and drying to obtain oxidized sodium alginate; the preparation method comprises the following steps: mixing acrylamide, 1-butyl-3-vinyl imidazole ammonium bromide, 3-acrylamide phenylboronic acid and quaternary ammonium salt chitosan, dissolving in water, adding ammonium persulfate and N, N-methylene bisacrylamide, heating for reaction, and cooling to obtain a cooling liquid; adding the oxidized sodium alginate solution into the cooling liquid, continuously adding polymerized N, N, N ', N'-tetramethylethylenediamine, reacting and curing to obtain composite hydrogel; and soaking the composite hydrogel in a glycerin / water mixed solution to obtain the composite hydrogel. When the composite hydrogel is used as a wound dressing, the composite hydrogel has the characteristics of good antibacterial activity, high sterilization efficiency, good anti-freezing and anti-drying performance and difficulty in generating drug resistance.

The invention discloses a milk-derived broad-spectrum antibacterial peptide and application thereof, and relates to the technical field of biology. The amino acid sequence of the antibacterial peptide is as shown in any one of SEQ ID NO.2-6. Five novel antibacterial peptides are obtained by carrying out symmetrical structure design and amino acid mutation on the basis of a template peptide, and tests find that the five novel antibacterial peptides have broad-spectrum antibacterial activity which is obviously higher than that of the template peptide, and basically have no cytotoxicity. Wherein the geometric mean (GM) of the minimum inhibitory concentration can reach 3.60, and the therapeutic index (TI) can reach 71.11. The antibacterial peptide prepared by the invention still keeps good antibacterial activity in physiological salt concentration and protease environment, has certain serum stability, and has higher application value; in addition, the antibacterial peptide has a good inhibition effect on the formation of a bacterial biofilm, and has a synergistic effect with traditional antibiotics.

The invention discloses a destabilizing enzyme fusion protein with improved activity, and the amino acid sequence of the destabilizing enzyme fusion protein is as shown in SEQ ID No.3 or SEQ ID No.5. According to the destabilizing enzyme fusion protein disclosed by the invention, the bacteriostatic activity, thrombolytic activity and isopeptidase activity of the destabilizing enzyme fusion protein are improved by optimizing the expression strategy and modifying the sequence of destabilizing enzyme Wpdestalase from whitmania pigra; and the application prospect and the application space of the Wpestabase are improved.

The invention discloses manganese and cerium co-doped modified sodium niobate, which is prepared from Nb2O5, MnO2, CeO2 and sodium hydroxide. The invention further discloses magnesium-based bone cement with the sonodynamic / nano-enzyme antibacterial function and the piezoelectric osteogenesis function. The magnesium-based bone cement is prepared from CaHPO4, NaH2PO4, MgO powder, hydroxyapatite and manganese-cerium co-doped modified sodium niobate. The magnesium-based bone cement with sonodynamic / nano-enzyme antibiosis and piezoelectric osteogenesis provided by the invention has piezoelectric enhanced sonodynamic and nano-enzyme synergistic antibacterial activity and piezoelectric osteogenesis activity, effectively removes bacteria / biological membranes, realizes combination of antibiosis and bone repair under different ultrasonic powers, effectively treats infectious bone defects, and has a good application prospect. The treatment effect of the MPC basal bone repair material is obviously improved.

The invention belongs to the technical field of biological medicines, and relates to an antibacterial polypeptide, a composition and application thereof. The amino acid sequence of the antibacterial polypeptide is as shown in SEQ ID NO. 1: KWKIKWPVKWFKM-NH2. The invention also discloses a preparation method of the antibacterial polypeptide. Experiments show that the antibacterial polypeptide disclosed by the invention has broad-spectrum antibacterial activity on gram-positive bacteria and / or gram-negative bacteria, and also has low cytotoxicity and low hemolysis. The antibacterial polypeptide provided by the invention consists of 14 amino acids, is relatively short in peptide chain, small in molecular weight and easy to artificially synthesize, is a micromolecular polypeptide with extremely high application value, can be used for preparing a novel antibacterial agent, and has a wide application prospect.

The invention discloses a biodegradable sanitary towel with polylactic acid as a main component. The biodegradable sanitary towel comprises a degradable core body, and the degradable core body comprises a surface layer, an absorption core layer and a bottom layer; the surface layer is a polylactic acid fiber non-woven fabric; the polylactic acid fiber non-woven fabric is a polylactic acid fiber spunlace non-woven fabric, a polylactic acid fiber hot air non-woven fabric or a polylactic acid spunbond non-woven fabric; the absorption core layer comprises an upper layer, a middle layer and a lower layer; the upper layer and the lower layer are made of polylactic acid fiber non-woven fabrics, and the middle layer is a mixture composed of polylactic acid two-component fibers and super absorbent resin. And the bottom layer is a degradable impermeable film which is a PHA modified polylactic acid film. The composite material has natural weak acidity and natural antibacterial activity, can create a weak-acidity antibacterial microenvironment for people, is skin-friendly, environment-friendly and healthy, and is an ideal selected material for disposable hygienic products. The natural antibacterial agent has the functions of natural bacteriostasis, weak acidity and the like, and is biodegradable.

The invention discloses application of a low-toxicity broad-spectrum antibacterial peptide taking WW as a symmetric center, WK is repeated twice and symmetrically distributed on two sides, WW is taken as the symmetric center to obtain an antibacterial peptide WKWKWWKWKW-NH2 (N2W2), and tryptophan at the C terminal and the N terminal of the N2W2 is replaced with leucine and / or isoleucine to obtain the antibacterial peptide. The antibacterial peptide can basically maintain the excellent antibacterial activity of the parent peptide, and the hemolytic activity of the antibacterial peptide is greatly reduced, so that the safety is improved. Wherein the antibacterial activity of IL-N2W2 is the highest, but the stability of IL-N2W2 needs to be improved, so that D-IL-N2W2 is obtained by carrying out D-type amino acid substitution on IL-N2W2. The D-IL-N2W2 keeps the high antibacterial activity and low toxicity of IL-N2W2, can still completely inhibit the growth of bacteria after being incubated with high-concentration trypsin or chymotrypsin, has great potential in the aspect of relieving the drug resistance of antibiotics, and has good application prospects in preparation of clinical antibacterial drugs.

Provided is an antibacterial peptide having an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, wherein X1 is selected from any one or of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y, and T or is absent; and X2 is an amino acid having an aromatic side chain or an amino acid having an alkaline side chain. In view of defects such as poor gastrointestinal fluid stability of antibacterial peptides in the prior art, a brand-new sequence design scheme and preparation method for an antibacterial peptide are provided. By means of a complete or partial D-amino acid substitution or structural derivatization of a peptide sequence, a series of antimicrobial peptides having stronger antibacterial activity and gastrointestinal stability as compared with the prior art are obtained, such that the antibacterial peptides have a wider application range and higher development potential value.

The invention discloses bacillus amyloliquefaciens GX0003936 and application thereof, and belongs to the technical field of microorganism application. The invention discloses bacillus amyloliquefaciens GX0003936 with a broad-spectrum bacteriostatic effect, which is preserved in the China General Microbiological Culture Collection Center on March 26, 2025, and the preservation number of the bacillus amyloliquefaciens GX0003936 is CGMCC (China General Microbiological Culture Collection Center) No.33987. The bacterial strain has broad-spectrum antibacterial activity, can be used for remarkably inhibiting the growth of mycelia of colletotrichum musae and colletotrichum frutescens, and can be used for remarkably reducing the disease incidence rate of tropical fruits such as bananas, mangoes and the like in the postharvest storage period. Meanwhile, the strain shows a good inhibition effect on various plant pathogenic fungi, and has a potential broad-spectrum biocontrol effect.

The invention discloses a full D-type antibacterial peptide with high enzymolysis stability and broad-spectrum antibacterial activity and application thereof. The antibacterial peptide is obtained by sequentially and repeatedly arranging D-type tryptophan, D-type arginine and D-type lysine for four times and carrying out C-terminal amidation; the amino acid sequence of the gene is (D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-NH2, and is marked as DWRK-12. The antibacterial peptide shows broad-spectrum antibacterial activity and excellent stability, can effectively resist clinically separated multidrug resistant strains, and keeps high cell selectivity at the same time. Due to the characteristics, the antibacterial peptide has important application value in the aspect of developing novel antibacterial drugs, especially in the field of treatment of infection of multiple drug-resistant bacteria.

The present invention belongs to the field of biotechnology, and discloses an antimicrobial peptide and a preparation method and use thereof. The antimicrobial peptide of the present invention is a mixture of any one or more of the polypeptides of RcASScGAK, RcASScGAKS, TGMRcASScGAK, and TGMRcASScGAKS. The present invention also provides a method for preparing the antimicrobial peptide by heterologous co-expression of a whole enzyme and a substrate, as well as a purification process of the antimicrobial peptide, which can successfully obtain high-yield and high-purity antimicrobial peptides, the required reagents are low-priced, the operation steps are simple and easy, and it is suitable for large-scale cultivation and purification; the antimicrobial peptide prepared by the present invention has excellent antimicrobial activity, and provides a new choice for the development of antimicrobial and anti-infective drugs.

The invention provides an antibacterial peptide and application thereof, and belongs to the technical field of biological medicine. Based on bioinformatics and an AI technology, a novel broad-spectrum antibacterial peptide is expected to be screened from tick (hard tick shoulder) genomes, and the antibacterial peptide has antibacterial activity on bacteria (including clinical drug-resistant strains) and fungi, does not have obvious cytotoxicity and hemolytic activity, and is an important candidate molecule of anti-infective drugs. In the embodiment of the invention, the minimum inhibitory concentration of the antibacterial peptide on gram-positive bacteria, gram-negative bacteria and fungi is verified, and the antibacterial peptide is proved to have obvious antibacterial activity on the gram-positive bacteria, the gram-negative bacteria and the fungi. The invention also verifies that the minimum inhibitory concentration of the antibacterial peptide to clinical drug-resistant bacteria is equivalent to the minimum inhibitory concentration of the antibacterial peptide to standard strains, and verifies that the antibacterial peptide can be used as a broad-spectrum antibacterial peptide and is named as SL-15.

The invention discloses bacillus velezensis XF-8 and application of the bacillus velezensis XF-8 in prevention and treatment of tomato bacterial wilt caused by Ralstonia solanacearum, and belongs to the technical field of microorganisms. The bacillus velezensis XF-8 capable of antagonizing Ralstonia solanacearum is obtained through separation and screening, and it is found that the bacillus velezensis XF-8 also has an excellent inhibition effect on various pathogenic fungi and shows broad-spectrum antibacterial activity of the bacillus velezensis XF-8. The bacillus velezensis XF-8 has a good inhibition effect on tomato bacterial wilt, and the control effect of the bacillus velezensis XF-8 in potted tomatoes reaches 74.25%. Results of the invention show that the bacillus velezensis XF-8 has a great application prospect in prevention and treatment of tomato bacterial wilt, and a good biocontrol resource is provided for research and development of a biocontrol agent for tomato bacterial wilt.

The invention belongs to the field of high polymer material chemistry, and particularly relates to double-network hydrogel based on sodium alginate / gelatin, a preparation method and dressing. A chemical method of grafting modification is adopted, grafting modification is carried out by designing abundant active groups on side chains of gelatin and sodium alginate, and based on traditional gelatin or sodium alginate hydrogel, not only is the thermal stability of gelatin improved, but also the biological activity of sodium alginate is improved, and the antibacterial property is achieved; the finally prepared SD / GelMA dual-network hydrogel wound dressing not only has excellent mechanical properties, but also has very high biocompatibility and antibacterial activity, and has huge application prospects and potential in the aspect of skin wound healing.

The invention discloses multifunctional paenibacillus polymyxa with straw degradation, broad-spectrum bacteriostasis and efficient insecticidal activity and application, and belongs to the technical field of agricultural microbiology. The strain provided by the invention is paenibacillus polymyxa BMB-Pp0021, and the preservation number of the strain of the paenibacillus polymyxa BMB-Pp0021 is CCTCC (China Center for Type Culture Collection) NO.M20241951; the bacterial strain not only has broad-spectrum antibacterial activity, but also can efficiently kill insects, also has the capability of efficiently degrading straws, and particularly still has the capability of efficiently degrading straws (the weight loss ratio in 7 days is 50.20%) under a low-temperature condition, so that the bacterial strain has huge application potential in agriculture and industry due to the multifunctional characteristics.

The invention relates to taurine cross-linked salicylic acid nano-composite gel for efficient transdermal delivery and mild acne removal as well as a preparation method and application of the taurine cross-linked salicylic acid nano-composite gel. The nano-gel comprises salicylic acid, quaternary ammonium salt-73, taurine, polyol, lipid, an emulsifier, a co-emulsifier, an antioxidant and water. Salicylic acid, quaternary ammonium salt-73 and taurine are used as functional components for removing acnes. Salicylic acid can decompose grease on the surface of the skin, so that the oil control effect is achieved, meanwhile, skin metabolism is promoted, angular suppository is loosened, pores are dredged, and acne is treated; quaternary ammonium salt-73 has extremely high antibacterial activity, especially has a remarkable antibacterial effect on propionibacterium acnes causing acnes, and can quickly and thoroughly remove the acnes by being matched with salicylic acid; taurine provides energy required by normal physiological activities of human cells, improves skin immunity, regulates skin water-oil balance and has the effects of improving skin textures, dryness, wrinkles, elasticity, sensitivity and other skin problems, meanwhile, in the using process, taurine is preferentially absorbed by the skin, so that an inclusion shell is broken, and the skin is protected. Rapid release and transdermal absorption of salicylic acid and quaternary ammonium salt-73 are promoted, irritation is reduced, and the three components act synergistically to achieve the functions of mildly, efficiently and rapidly treating acne and reconstructing skin barrier.

The invention relates to a high-barrier antibacterial polylactic acid packaging material and a preparation method thereof, and belongs to the technical field of biodegradable packaging materials. The technical problems that a traditional polylactic acid material is insufficient in barrier property, poor in antibacterial performance and difficult to meet the packaging requirements of livestock and poultry meat, food and medicine are solved. A graphene oxide lamellar material is subjected to copper ion functionalization treatment and is bridged with tannic acid molecules through copper ions to form a nano filler, and then the filler is blended with a plasticized polylactic acid solution to prepare the membrane. The preparation method comprises the following steps: preparing a copper ion functionalized dispersion liquid from graphene oxide and copper nitrate, self-assembling the copper ion functionalized dispersion liquid and tannic acid under the condition that the pH is 8-10 to generate a nanofiller, uniformly dispersing the nanofiller, mixing the nanofiller with polylactic acid, polyethylene glycol and glycerol according to a specific mass ratio, coating to form a film, and controlling solvent volatilization conditions to obtain the high-performance packaging material. According to the method, the oxygen barrier property and the antibacterial activity of the material are remarkably improved through uniform dispersion of the nanofiller and reinforcement of a coordination network. The obtained material is suitable for packaging foods such as livestock and poultry meat.