1703 results about "Antibacterial activity" patented technology

The invention provides a streptomyces, which is named as Streptomyces sp. And is registered and preserved in Guangdong Microbial Culture Collection Center, and the preservation number is GDMCC No: 65917. The invention also provides a fermentation broth of the streptomyces, and an ethanol extract and a crude extract of the fermentation broth. The novel streptomyces, the crude extract thereof and the like have broad-spectrum antibacterial activity, have a good antagonistic effect on various pathogenic bacteria such as banana long leaf spot germs and banana colletotrichum gloeosporioides, can enable hyphae of the banana colletotrichum gloeosporioides to shrink, deform and break, inhibit spore germination of the banana colletotrichum gloeosporioides, and have a good anti-bacterial effect on the banana colletotrichum gloeosporioides. According to the present invention, with the application of the bacterial strain, the colletotrichum gloeosporioides spores are shrunk and broken, the growth of the colletotrichum gloeosporioides is inhibited, the peroxidase activity, the polyperoxidase activity, the CAT activity and the like in the banana peel can be improved, and the bacterial strain is the potential biological agent for the prevention and control of the colletotrichum gloeosporioides diseases, and has wide development space and good development and application prospects.

Provided is an antibacterial peptide having an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, wherein X1 is selected from any one or of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y, and T or is absent; and X2 is an amino acid having an aromatic side chain or an amino acid having an alkaline side chain. In view of defects such as poor gastrointestinal fluid stability of antibacterial peptides in the prior art, a brand-new sequence design scheme and preparation method for an antibacterial peptide are provided. By means of a complete or partial D-amino acid substitution or structural derivatization of a peptide sequence, a series of antimicrobial peptides having stronger antibacterial activity and gastrointestinal stability as compared with the prior art are obtained, such that the antibacterial peptides have a wider application range and higher development potential value.

The invention discloses bacillus amyloliquefaciens GX0003936 and application thereof, and belongs to the technical field of microorganism application. The invention discloses bacillus amyloliquefaciens GX0003936 with a broad-spectrum bacteriostatic effect, which is preserved in the China General Microbiological Culture Collection Center on March 26, 2025, and the preservation number of the bacillus amyloliquefaciens GX0003936 is CGMCC (China General Microbiological Culture Collection Center) No.33987. The bacterial strain has broad-spectrum antibacterial activity, can be used for remarkably inhibiting the growth of mycelia of colletotrichum musae and colletotrichum frutescens, and can be used for remarkably reducing the disease incidence rate of tropical fruits such as bananas, mangoes and the like in the postharvest storage period. Meanwhile, the strain shows a good inhibition effect on various plant pathogenic fungi, and has a potential broad-spectrum biocontrol effect.

The invention discloses a full D-type antibacterial peptide with high enzymolysis stability and broad-spectrum antibacterial activity and application thereof. The antibacterial peptide is obtained by sequentially and repeatedly arranging D-type tryptophan, D-type arginine and D-type lysine for four times and carrying out C-terminal amidation; the amino acid sequence of the gene is (D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-(D-Trp)-(D-Arg)-(D-Lys)-NH2, and is marked as DWRK-12. The antibacterial peptide shows broad-spectrum antibacterial activity and excellent stability, can effectively resist clinically separated multidrug resistant strains, and keeps high cell selectivity at the same time. Due to the characteristics, the antibacterial peptide has important application value in the aspect of developing novel antibacterial drugs, especially in the field of treatment of infection of multiple drug-resistant bacteria.

The invention discloses bacillus velezensis XF-8 and application of the bacillus velezensis XF-8 in prevention and treatment of tomato bacterial wilt caused by Ralstonia solanacearum, and belongs to the technical field of microorganisms. The bacillus velezensis XF-8 capable of antagonizing Ralstonia solanacearum is obtained through separation and screening, and it is found that the bacillus velezensis XF-8 also has an excellent inhibition effect on various pathogenic fungi and shows broad-spectrum antibacterial activity of the bacillus velezensis XF-8. The bacillus velezensis XF-8 has a good inhibition effect on tomato bacterial wilt, and the control effect of the bacillus velezensis XF-8 in potted tomatoes reaches 74.25%. Results of the invention show that the bacillus velezensis XF-8 has a great application prospect in prevention and treatment of tomato bacterial wilt, and a good biocontrol resource is provided for research and development of a biocontrol agent for tomato bacterial wilt.

The invention relates to a high-barrier antibacterial polylactic acid packaging material and a preparation method thereof, and belongs to the technical field of biodegradable packaging materials. The technical problems that a traditional polylactic acid material is insufficient in barrier property, poor in antibacterial performance and difficult to meet the packaging requirements of livestock and poultry meat, food and medicine are solved. A graphene oxide lamellar material is subjected to copper ion functionalization treatment and is bridged with tannic acid molecules through copper ions to form a nano filler, and then the filler is blended with a plasticized polylactic acid solution to prepare the membrane. The preparation method comprises the following steps: preparing a copper ion functionalized dispersion liquid from graphene oxide and copper nitrate, self-assembling the copper ion functionalized dispersion liquid and tannic acid under the condition that the pH is 8-10 to generate a nanofiller, uniformly dispersing the nanofiller, mixing the nanofiller with polylactic acid, polyethylene glycol and glycerol according to a specific mass ratio, coating to form a film, and controlling solvent volatilization conditions to obtain the high-performance packaging material. According to the method, the oxygen barrier property and the antibacterial activity of the material are remarkably improved through uniform dispersion of the nanofiller and reinforcement of a coordination network. The obtained material is suitable for packaging foods such as livestock and poultry meat.

The invention discloses pediococcus acidilactici NDF12 and application thereof, the pediococcus acidilactici NDF12 is preserved in Guangdong Microbial Culture Collection Center on January 8, 2025, is called GDMCC for short, and the preservation number is GDMCC NO: 65732. The invention further discloses a preparation method of the pediococcus acidilactici NDF12. The strain is derived from Chinese local traditional dairy products, phenotype and genotype safety evaluation proves that the strain is safe and non-toxic, has excellent fermentation characteristics and probiotic characteristics, and can be used as a leavening agent for producing yoghourt. The bacterial strain also has gastrointestinal fluid endurance capacity, adhesion capacity, bacteriostatic activity, antioxidant activity, cholesterol lowering activity and blood sugar lowering activity, and has great application prospects in the fields of foods, medicines, feeds and the like.

The invention provides a plant lactobacillus YH001 with bacteriostatic activity as well as a screening method and application of the plant lactobacillus YH001. The phytobacterium plantarum YH001 has the taxonomic name of Lactiplantibacillus plantarum, is preserved in the Guangdong Microbial Culture Collection Center, and has the preservation number of GDMCC No: 65693, the preservation number of Lactiplantibacillus plantarum YH001 is CGMCC NO: 65693, and the preservation number is CGMCC NO: 65693. The preservation date is December 30, 2024. The strain has excellent biological characteristics of no hemolysis, acid resistance, cholate resistance and the like, and has wide application potential in the fields of food, medicine and the like. The fermentation supernatant still keeps high bacteriostatic activity after being treated at a high temperature of 121 DEG C, and shows excellent thermal stability. Therefore, the strain has a wide application prospect in research and development of antibacterial agents, food leavening agents and preservative products.

The invention belongs to the field of biological agents, and particularly relates to bacillus siamensis and application thereof in the aspects of plant disease control, growth promoting and yield increasing. The bacillus siamensis XNC-3 provided by the invention is wide in antibacterial spectrum, can effectively inhibit various plant pathogenic fungi including phytophthora parasitica var nicotianae, has broad-spectrum antibacterial activity, and can be used for preventing and treating plant diseases, especially tobacco diseases. The bacillus siamensis has a promoting effect on tobacco seedling growth and seed germination, has growth-promoting and yield-increasing effects on tobacco, can remarkably increase the tobacco yield and improve the tobacco quality, is safe to the environment and has a very good application prospect.

The invention discloses a macrocyclic covalent organic polymer material for inhibiting a pi-pi stacking effect and application of the macrocyclic covalent organic polymer material, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: adding 5, 10, 15, 20-tetra (4-ethynylphenyl) copper porphyrin and a macrocyclic monomer into an organic solvent in a protective atmosphere, and carrying out solvothermal reaction in the presence of a catalyst and alkali to obtain the macrocyclic covalent organic polymer material. According to the invention, 5, 10, 15, 20-tetra (4-ethynylphenyl) copper porphyrin and a macrocyclic monomer form a porous polymer MCP-CU-POP, the material utilizes the photo-thermal capability to combine the effects of simulated photo-thermal (PTT), photodynamic (PDT), peroxidase (PODs) and glutathione peroxidase (GSH-Px) to perform synergistic antibiosis, and the inherent characteristics of an infected microenvironment can also be utilized to induce death of bacteria, so that the antibacterial property of the material is greatly improved, and the antibacterial property of the material is greatly improved. And the microenvironment of the bacterial infection part can be adjusted, so that the recovery of the bacterial infection wound can be obviously accelerated.

The invention provides a cyclic peptide as well as a preparation method and application thereof. The cyclic peptide has an amino acid sequence # imgabs0 # represented by formula (1) (wherein X is a Lys residue modified with a fatty acid molecule, and a line connecting Arg and Lys represents an amide bond. The cyclic peptide prepared by the invention has wide antifungal activity and antibacterial activity on drug-resistant bacteria; meanwhile, the biotoxicity and the protease degradation resistance are high, and the in-vivo antibacterial effect of the cyclopeptide can be prolonged. The cyclic peptide can be applied to preparation of anti-bacterial and anti-fungal infection drugs, and can be used as an excellent substitute drug or an auxiliary drug of existing antibiotics. The method for preparing the cyclic peptide is simple, raw materials are easy to obtain, and industrial production can be achieved.

The invention discloses an eel antibacterial polypeptide Ajaspkidin and application thereof in preparation of an anti-vibrio composition. The amino acid sequence of the eel antibacterial polypeptide Ajaspkidin is shown as SEQ ID NO.01. The invention further discloses an application of the eel antibacterial polypeptide The zebra fish antibacterial peptide has the characteristics of excellent molecular characteristics, broad-spectrum antibacterial activity, efficient bactericidal ability, high thermal stability, high biological safety, anti-infection effect on zebra fish infected by vibrio vulnificus, capability of remarkably improving the survival rate of bred animals and the like, and has a wide application prospect.

The invention relates to the technical field of microorganisms, and particularly discloses bacillus velezensis DSSR-2, a biocontrol microbial agent and application of the bacillus velezensis DSSR-2, the bacillus velezensis DSSR-2 is preserved in the China General Microbiological Culture Collection Center on July 8, 2024, the preservation number is CGMCC No.31207, and the bacillus velezensis DSSR-2 is classified and named as bacillus velezensis. The bacillus velezensis DSSR-2 provided by the invention has broad-spectrum antibacterial activity and can be used for inhibiting pathogenic bacteria of plant diseases, so that the plant diseases are prevented and treated, and meanwhile, the growth and development of plants are promoted.

The invention belongs to the technical field of gene engineering, and particularly relates to ALFPm3 modified antibacterial peptide, a molecular design and construction method and application of the ALFPm3 modified antibacterial peptide, and the amino acid sequence of the ALFPm3 modified antibacterial peptide is selected from any one of SEQ ID NO: 1-SEQ ID NO: 7. Analysis and design are carried out by combining the structure and action site of vibrio parahaemolyticus and the molecular structure and function relationship of the antibacterial peptide ALFPm3 as a basic template, the antibacterial activity of the antibacterial peptide ALFPm3 is improved, and other biological activities such as hemolysis are reduced.

The invention relates to the technical field of antibacterial drugs, in particular to an antibacterial peptide which has an amino acid sequence X1KRFKKFFX2KLKKWV-NH2, in which X1 is selected from any one or deletion of amino acids A, C, D, E, F, G, H, K, L, N, M, P, Q, R, S, I, V, W, Y and T; and X2 represents an amino acid having an aromatic side chain or an amino acid having a basic side chain. Aiming at the defects of poor gastrointestinal fluid stability and the like of the antibacterial peptide in the prior art, the invention provides a brand new antibacterial peptide sequence design scheme and a preparation method thereof, and the peptide sequence is subjected to full D-type amino acid or partial D-type amino acid replacement or structure derivation; compared with the prior art, a series of antibacterial peptides with higher antibacterial activity and gastrointestinal fluid stability are obtained, so that the antibacterial peptides have wider application range and higher potential development value.

Provided are an antibacterial peptide and the use thereof. The antibacterial peptide has a structure represented by formula (I), wherein Z1 is selected from tetrapeptides, the tetrapeptides being optionally modified by -OH, -CHO, -COOH, -NH2, -SO3H or -C=O; S1 and S2 are each independently selected from amino acids having the structure of (I); Q1 and Q2 are each independently selected from dipeptides or tripeptides; and n is independently selected from any integer between 1 and 6. (Q2)4-(S2-Q1)2-S1-Z1

The invention relates to the technical field of biological materials, in particular to silver nano-chlorogenic acid composite hydrogel as well as preparation and application thereof. According to the invention, the CGA and the silver nitrate are used for green synthesis of the nano-particles CGA-AgNPs, and the nano-particles have peroxide nano-enzyme activity and antibacterial activity; and the CGA-AgNPs and chitosan (CS) are cross-linked to form the silver nano-chlorogenic acid composite hydrogel CGA-AgNPs-CS, so that the uniform distribution of nano-particles in the hydrogel can be promoted. According to the invention, multi-functionalization is taken as a target, a novel hydrogel composition system is designed from the source, the provided preparation method is green, simple, rapid and environment-friendly, the obtained composite hydrogel has multiple functions, and a good foundation is laid for expansion and application of the composite hydrogel in the biomedical fields of wound repair, wearable equipment, nano antibacterial drugs and the like.

The invention discloses an African trichoderma harzianum strain 6-5 and application thereof, the disclosed strain is named as Trichoderma harzianum, and the preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) No. 41930. The bacterial strain has obvious bacteriostatic activity on crop pathogenic bacteria such as colletotrichum capsici, apple cyst, botrytis cinerea, alternaria longibrachiata and phytophthora capsici, and fermentation liquor of the bacterial strain has good prevention and control effects on apple anthracnose leaf blight, apple bitter rot and apple tree canker.

The invention discloses a method and a system for detecting an antibacterial coating micro guide wire. The method comprises the following steps: applying a composite stress field to a guide wire to obtain stress distribution data; determining a stress response abnormal area according to the stress distribution data and applying dual-frequency vibration excitation to obtain nonlinear vibration response data and vibration energy dissipation data; force-sensitive fluorescent molecules are applied to the stress response abnormal area for treatment, and conformational changes of the stress response abnormal area are monitored to obtain preliminary spatial distribution data of the microcracks; injecting a multi-ion fluorescent tracer into the micro-crack area, and monitoring the migration rule of the multi-ion fluorescent tracer to obtain pH value distribution data and oxidation-reduction potential distribution data; bacterial suspension with specific fluorescence response is injected into the micro-crack area, and antibacterial activity evaluation data is obtained by monitoring the fluorescence response of the bacterial suspension. According to the technical scheme, the microcracks on the surface of the antibacterial coating micro guide wire are accurately detected and positioned, and the influence degree of the microcracks on the antibacterial function can be accurately evaluated.

The invention relates to the technical field of reverse osmosis membranes, in particular to a multilayer composite anti-biological-pollution reverse osmosis membrane and a preparation method thereof. The reverse osmosis membrane is prepared by the method. The method comprises the following steps: immersing a base membrane into a prepared water phase solution, and sequentially carrying out first immersion treatment and drying treatment in the shade to obtain a first membrane sheet; immersing the first membrane into a prepared organic phase solution, removing the redundant organic phase solution on the first membrane after second immersion treatment, and obtaining a second membrane after interface reaction; and immersing the second membrane into a prepared antibacterial metal ion solution, and carrying out complexation reaction to obtain the multi-layer composite anti-biological-pollution reverse osmosis membrane. According to the invention, the multilayer composite anti-biological pollution reverse osmosis membrane with prolonged antibacterial activity and improved membrane separation performance can be prepared.

The invention discloses lysozyme, antibacterial peptide derived from the lysozyme and application of the lysozyme in preparation of antibacterial drugs. According to the invention, 1, 640 protein sequences recorded in a ruminant rumen caterpillars genome database are systematically predicted based on a lysozyme prediction model, and finally, the lysozyme with the amino acid sequence as shown in SEQ ID No.1 is relatively strong in antibacterial activity and stable in antibacterial activity, and is slightly influenced by environmental factors. According to the invention, an antibacterial peptide region of the lysozyme is analyzed and determined, three peptide fragments with clear antibacterial activity are identified, and the amino acid sequences of the peptide fragments are respectively shown as SEQ ID No.2, SEQ ID No.3 or SEQ ID No.4. The antibacterial peptide provided by the invention has relatively strong membrane destroying ability and broad-spectrum antibacterial activity, and compared with integral protein, the antibacterial peptide is simpler in structure and more flexible in synthesis and modification, and is easier to break through a bacterial drug-resistant mechanism.

The present invention relates to the field of genetic engineering technology, specifically disclosing a raccoon dog interferon-α and β-defensin fusion protein, its encoding gene, and its application. The raccoon dog interferon-α and β-defensin fusion protein has the amino acid sequence shown in SEQ ID NO:1. The present invention also provides a gene encoding the fusion protein, a recombinant expression vector, and a host cell. The fusion protein provided by the present invention possesses the dual biological activities of raccoon dog interferon-α and β-defensin, and has certain antiviral and antibacterial activities.

The invention relates to the technical field of polypropylene, in particular to an antibacterial modified polypropylene material and a preparation method thereof. The problems of poor antibacterial property and mechanical property of the polypropylene material are solved. According to the invention, the carbon nanotube is used as a carrier, ZnO nanoparticles are grafted on the surface, and the carbon nanotube and the polypropylene resin are subjected to interface synergy and functional complementation, so that the mechanical property and antibacterial activity of the material are synchronously improved; through the short-range-long-range synergistic effect of the short carbon fibers and the glass fibers treated by the silane coupling agent KH550, the fracture resistance of the material is remarkably improved; through the molecular-level synergistic effect of hydroxylated boron nitride nanosheets and maleic anhydride grafted polypropylene, the interfacial compatibility of the nanofiller and a polypropylene matrix is optimized, and the mechanical property of the material is improved; the antibacterial microcapsule is prepared by taking chitosan as a carrier, wrapping hinokitiol and loading nano titanium dioxide, and the material is endowed with long-acting antibacterial performance.

The invention discloses an anguilla anguilla antibacterial peptide Anguinin and application thereof. The amino acid sequence of the anguilla anguilla antibacterial peptide Anguinin is shown as SEQ ID NO. 01. The amino acid sequence consists of 18 amino acid residues, and the molecular weight of the amino acid sequence is 2091.41 Daltons. According to the prediction of a HeliQuest tool, the net charge number is + 5, the hydrophobicity value is 0.267, and meanwhile, good water solubility is shown. As a typical cationic polypeptide with positive charges, the cationic polypeptide has the remarkable advantages of being easy to chemically synthesize, wide in antibacterial spectrum, efficient in antibacterial activity, high in safety and the like, a solid foundation is laid for practical application of the cationic polypeptide in the fields of pharmacy and feed addition due to the characteristics, and wide commercialization prospects are shown.

The invention belongs to the technical field of biological medicines and micro-nano motors, and particularly relates to a self-driven micro-motor system for treating helicobacter pylori gastritis and a preparation method of the self-driven micro-motor system. A self-driven micro-motor system with an active targeting function is constructed, the drug coated on the PLGA layer can be any substance with antibacterial activity or capable of promoting gastric mucosa repair, and the drug loading capacity and the sustained release time can be adjusted by adjusting the thickness of the PLGA interlayer. The selection of the enteric coating layer mainly considers the good electrostatic targeting property and pH response release property of the enteric coating layer, and various types of enteric coatings can be selected to adjust pH nodes released by the shell.

The invention discloses cinnamyl aldehyde at nano calcium carbonate / chitosan hydrogel. The hydrogel comprises a hydrogel matrix formed by cross-linking nano calcium carbonate and chitosan, and cinnamyl aldehyde loaded on the hydrogel matrix. The hydrogel system which is loaded with traditional Chinese medicine components and intelligently controls effective release of the traditional Chinese medicine components is prepared by utilizing the mutual adsorption effect of cinnamyl aldehyde and nano calcium carbonate. The hydrogel has excellent antibacterial activity and a function of accelerating wound healing, and the effect of the hydrogel is obviously superior to that of common calcium carbonate / chitosan hydrogel. A new direction is provided for application of the cinnamyl aldehyde and nano calcium carbonate / chitosan nano system, and a new strategy is provided for designing advanced functional materials modified by traditional Chinese medicine ingredients.

The invention relates to the technical field of medicines, in particular to application of tedizolid combined with fluconazole in preparation of antifungal drugs. The tedizolid and the fluconazole are combined for use, so that the antibacterial activity of the fluconazole on the candida albicans can be enhanced, a synergistic antifungal effect can be generated, and the drug resistance of the candida albicans on the fluconazole can be reversed.

The present invention discloses a sea dragon-derived antimicrobial peptide, SsPle, for antimicrobial applications in the complex environments of tropical islands and reefs. The amino acid sequence of this antimicrobial peptide is shown in SEQ ID NO. 3. This antimicrobial peptide, SsPle, exhibits good water solubility, broad antimicrobial activity, and highly stable antimicrobial properties under high temperature, high salt, and ultraviolet irradiation conditions. It can inhibit the release of free bacterial endotoxins and has significant application prospects as an eco-friendly antimicrobial agent in the unique environments of South China Sea islands and reefs.

The invention provides a fluorenyl alcohol derivative which can be used as an antibiotic adjuvant with a broad-spectrum synergistic effect. According to the compound, bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are taken as targets, and a series of fluorenyl alcohol derivatives targeting the bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are obtained through screening. The preferable compound WTU-15 can improve the antibacterial activity of antibiotics such as polymyxin, cefepime, tetracycline and the like on negative bacteria such as sensitive and drug-resistant escherichia coli, salmonella, klebsiella pneumoniae, acinetobacter baumannii and the like, and can also improve the in-vivo treatment effect of cefepime on mice infected by the drug-resistant acinetobacter baumannii. And the visceral organs of the mice survived after administration have fewer bacteria, and the mice are better after being healed. Normal physiological and visceral organ functions of the mouse are not affected by single and continuous administration of the WTU-15.

The invention relates to the technical field of composite antibacterial materials, in particular to a preparation method and application of a spike rod-shaped nano composite material Cu-Fe-MOF (at) Ag. Rod-shaped Fe-MOF with biocompatibility is used as a carrier, Cu < 2 + > is introduced, and the appearance of the Fe-MOF is adjusted into a spike type, so that the antibacterial activity of the Fe-MOF is enhanced. On the basis of a soft and hard acid-base theory, by utilizing the principle that a d electron orbit of nano Ag is full electrons and is easy to coordinate with O and N atoms in Cu-Fe-MOF, the rodlike spike Cu-Fe-MOF (at) Ag composite nano material which can be adaptive to infected wound healing and intelligently adjust antibacterial activity and ROS (reactive oxygen species) removal capability is prepared through dual effects of adsorption and coordination. According to the material, the antibacterial activity of nano Ag can be improved, due to existence of coordinate bonds, the problem that Ag NPs are difficult to agglomerate and recycle can be solved, the problem of toxicity caused by accumulation of nano Ag on infected wounds is solved, and meanwhile, under the alkaline condition, conjugated bonds in MOF can cooperate with Ag to improve the ROS removal capacity.