4 results about "Pasteurellosis" patented technology

The invention belongs to the technical field of microorganisms, and particularly relates to rabbit source D-type pasteurella multocida and application thereof. The preservation number of the strain is CCTCC (China Center For Type Culture Collection) NO: M 2024856. The strain induces cellulosic pneumonia, has an application value of constructing a rabbit pasteurellosis animal model, and has good immunogenicity, a whole-cell inactivated antigen can effectively stimulate immune response of a mouse body and induce generation of a high-level antibody, and the strain has the potential of being developed into a vaccine.

This invention discloses a method for preparing and applying a Pasteurella-Bordetella nanovaccine, belonging to the field of biomedical technology. The method includes the following steps: emulsifying epigallocatechin gallate, an antigen aqueous phase, and soybean oil under high-speed shearing, followed by homogenization to form a stable oil-in-water emulsion, which is the Pasteurella-Bordetella nanovaccine. Challenge experiments confirmed that the ESO vaccine achieved a protection rate of up to 90% against Pasteurella multocida and Bordetella bronchiseptica, significantly superior to the 40%-70% protection rate of the aluminum adjuvant group. Simultaneously, it significantly reduced the bacterial load in the lungs, demonstrating excellent clinical protective effects. This invention, through the innovative combination of EGCG and vegetable oil, overcomes the limitations of traditional adjuvants in terms of immunogenicity, safety, and single function, providing a highly efficient and safe new vaccine solution for the prevention and control of Pasteurella multocida and Bordetella multocida infections.

The invention discloses a preparation method and application of a pasteurization-bordetella nanometer vaccine, and belongs to the technical field of biological medicine. Comprising the following steps: carrying out high-speed shearing emulsification on epigallocatechin gallate, an antigen water phase and soybean oil, and homogenizing to form a stable oil-in-water emulsion, namely the pasteurization-bordetella nano vaccine. A challenge test proves that the protection rate of the ESO vaccine to pasteurella multocida and bordetella bronchiseptica reaches up to 90%, which is obviously superior to the 40-70% protection rate of an aluminum adjuvant group, and meanwhile, the lung bacterium loading amount is obviously reduced, so that the ESO vaccine shows an excellent clinical protection effect. The EGCG and the vegetable oil are innovatively compounded, so that the limitation of the traditional adjuvant in the aspects of immune efficacy, safety and function singleness is broken through, and an efficient and safe novel vaccine solution is provided for prevention and control of pasteurellosis and bordetella disease.

The invention provides a pig lung pasteurization disease management system and method, electronic equipment and a medium, and the system comprises an image obtaining module which is used for obtaining a plurality of groups of original pig lung images; the image processing module is used for performing image processing on each group of original pig lung images to obtain a target lung image; the image recognition module is used for recognizing the target lung image based on a pre-trained Pasteur disease recognition model to obtain a Pasteur disease recognition result; and the result analysis module is used for analyzing the pasteurization disease recognition result and determining a breeding scheme based on the analysis result. The method can improve the recognition efficiency, saves the manpower of manual evaluation, and improves the health level of pig breeding.