Fowl multi-killed pasteurellosis bacillus live vaccine

Abstract

The present invention discloses one kind of live vaccine of fowl Pasteur's multocidum bacterium and its preparation process, and belongs to the field of biological product technology. The live vaccine is prepared with natural low virulent strain P7810 of fowl Pasteur's multocidum bacterium, and through steps of anabiosis and passage of the bacterium seed to form seed bacterium liquid, culturing to proliferate, adding gelatin in 1.5 % and cane sugar in 5 %, packing and freeze drying to obtain live vaccine of fowl Pasteur's multocidum bacterium P7810. The live vaccine is fed to fowl for immunizing to prevent fowl cholera, and has immunizing period as long as 6 months, high protecting rate, low cost and other advantages.

Description

technical field

[0001] The invention relates to a Pasteurella multocida live vaccine used for oral immunization of poultry and a preparation method of the vaccine, belonging to the technical field of biological products. Background technique

[0002] Pasteurella multocida (Pasteurella multocida P.m) is a contact septic infectious disease that causes fowl cholera in poultry and wild fowl, with high morbidity and mortality. Infected birds can die within 48 hours of 90% -100%. At present, in my country's poultry infectious diseases, especially waterfowl (ducks and geese), the economic losses caused by fowl cholera are still very serious. According to poultry epidemic statistics, the number of poultry deaths due to fowl cholera epidemic accounts for 1.3% of the total annual poultry breeding in my country and 1.9% of the total water fowl breeding. At present, the vaccine products used in my country to prevent fowl cholera include "fowl cholera propolis inactivated vaccine", "fo...