26 results about "Biologic Products" patented technology

A system may select a first feature and a second feature of the biologic product. The system may determine a first biologic parent having the first feature and not having the second feature, wherein the first feature is based on an aspect of the first biologic parent. The system may determine a second biologic parent having the second feature and not having the first feature, wherein the second feature is based on an aspect of the first biologic parent, and the aspect of the second biologic parent can be combined with the aspect of the first biologic parent. The system may determine a biologic product having the first feature and the second feature, wherein the biologic product is determined based on an evaluation of a set of combinations of the aspect of the first biologic parent and the aspect of the second biologic parent.

The present application belongs to the technical field of microorganisms, and particularly relates to a bacillus licheniformis BL-C15 and application thereof. The present application provides a bacillus licheniformis BL-C15, which is characterized in that the bacillus licheniformis BL-C15 is preserved in the China General Microbiological Culture Collection Center on November 25, 2024, has a preservation number of CGMCC No. 32787, and has a preservation address of No. 3, Xili, Beichen, Beijing, China. The strain has the characteristics of high-alkali tolerance, salt tolerance and acid production, can effectively repair saline-alkali degraded soil, has a significant plant growth-promoting effect, and has important application value in the field of saline-alkali soil repair. The strain can also be used for preparing a microbial product for repairing saline-alkali soil.

The present application belongs to the field of microbial preparation, and discloses a kind of microbial stabilizer, including non-bacillus or its fermentation bacteria liquid, chemical stabilizer, wherein, the non-bacillus includes at least one of Serratia entomophila, Acinetobacter calcoaceticus.The present application also discloses the preparation method of the microbial stabilizer and its application in prolonging the shelf life of microbial agent.The present application studies the microbial stabilizer containing non-bacillus, finds that the microbial stabilizer formed by the suitable collocation of non-bacillus and chemical stabilizer can maintain the stability of viable bacterial concentration for a long time, can prolong the shelf life of microbial product, reduces the need for frequent production and storage, can ensure the supply of product in market more stable, thereby directly reduces the production cost, improves economic benefit, can be used in the field of microbial preparation technology.

The present disclosure relates to a genetically engineered biological product, the genetically engineered product having a plurality of cells cohered in three dimensions, where the cells have differentiated from a single cell source into at least two differentiated cell types, and where the cells commonly contain a plurality of genomic alterations that are each respectively neuron-depleting and / or neuron disrupting, central nervous system restricting, central nervous system disrupting, and / or body plan restricting, where the biological product is a sac encasing at least one organ. The present disclosure also provides methods for producing the genetically engineered biological product.

This application relates to a computer-implemented method, computer-readable medium, and system for storing heterogeneous sequences of discrete-time data determined from processes producing chemicals, pharmaceuticals, biopharmaceuticals, and / or biological products. The method includes receiving discrete-time data, which includes first data from a first scientific instrument. The method also includes receiving second data from a second scientific instrument. The first and second scientific instruments each have different corresponding observation types, the first data having a first observation type, and the second data having a second observation type. The method further includes: storing the first data and first metadata in a first record of a database, the first data being stored according to the function of stored data mapped by the first observation type; and storing the second data and second metadata in a second record of the database, the second data being stored according to the function of stored data mapped by the second observation type.

The utility model relates to the technical field of clean engineering technical support discloses a process water through plate joint for biological product workshop clean workshop, including tubular body, the front part of tubular body is equipped with the connecting structure for connecting with outside pipeline, the middle part of tubular body is equipped with the fastening structure for fastening process water through plate joint on the wallboard, the rear part of tubular body is equipped with the chuck of quick -mounting clamp joint, the middle part of tubular body has the locating ring that forms radially outward expansion, the locating ring is arranged between fastening structure and chuck, and the locating ring has the sealing surface for abutting on the wallboard of arrangement to the front. In this way, through the design of chuck and connecting structure on process water through plate joint, realize the mutual connection of process pipeline in biological product workshop clean workshop production equipment and technical aisle, and connection is convenient to detach, and installation is simple. And, through the sealing surface abutment on the wallboard of biological product workshop clean workshop, realize the tight sealing.

Immune cells are separated out through human peripheral blood, a byproduct supernatant is obtained in the process of culturing the immune cells in a GMP laboratory, the supernatant serves as one of main components of a finished product according to existing known science and technology, biological natural laws and special effects, a substrate solution and dressing mode is adopted as an external carrier for skin, and the external carrier is used as an external carrier for the skin. According to the present invention, the immune cell supernatant is applied to the skin surface so as to obtain the method of introducing various cell bioactive components from the immune cell supernatant and acting on the skin surface to the deep layer, such that the skin care product with characteristics of skin cell activation moisturizing, regeneration repairing and physiological aging delaying can be provided, and the significant multi-effect purpose can be provided; and the technical method of biological products can be organized and produced under specific GMP production conditions.

A system may receive information about a biologic product, wherein the information includes a description of at least a portion of the biologic product in an expression language. The system may generate a set of edits of the biologic product based on the description the at least a portion of the biologic product in the expression language. The system may generate a performance prediction for each edit of the set of edits of the biologic product based on a pre-trained genetic generalization model applied to each edit of the set of edits.

Described herein are fusion proteins including methanol dehydrogenase (MeDH) and at least one other polypeptide such as 3-hexulose-6-phosphate dehydrogenase (HPS) or 6-phospho-3-hexuloisomerase (PHI), such as DHAS synthase or fructose-6-Phosphate aldolase or such as DHA synthase or DHA kinase. In a localized manner, the fusion protein can promote the conversion of methanol to formaldehyde and then to a ketose phosphate such as hexulose 6-phosphate or then to DHA and G3P. When expressed in cells, the fusion proteins can promote methanol uptake and rapid conversion to the ketose phosphate or to the DHA and D3P, which in turn can be used in a pathway for the production of a desired bioproduct. Beneficially, the rapid conversion to the ketose phosphate or to the DHA and G3P can avoid the undesirable accumulation of formaldehyde in the cell. Also described are engineered cells expressing the fusion protein, optionally include one or more additional metabolic pathway transgene(s), methanol metabolic pathway genes, target product pathway genes, cell culture compositions including the cells, methods for promoting production of the target product or intermediate thereof from the cells, compositions including the target product or intermediate, and products made from the target product or intermediate.

The present invention provides a method of inactivating enveloped viruses during the production of a biologic product without harming the biologic product. The method comprises contacting cells containing the biologic product with at least one purified non-ionic detergent, wherein the detergent(s) lyses the cells to release the biologic product, thereby producing a lysate, and wherein the detergent(s) inactivates any enveloped viruses within the lysate. The detergent can be an ethoxylated alcohol, sorbiton ethoxylate, triblock copolymer and combinations thereof. Examples of biologic products include non-enveloped viruses and therapeutic recombinant proteins produced via lysis of mammalian or insect cells.

Platforms, systems, and methods for multi-objective optimization and comparative analysis for synthetic biology development. According to one aspect, there is provided a method of generating a biologic product of a biologic synthesis process, comprising: selecting a first biologic parent having a first feature; selecting a second biologic parent having a second feature; and selecting the biologic product based on an evaluation of a set of combinations of the first biologic parent and the second biologic parent.

To provide methods for the continuous production, capture, and purification of biologics such as recombinant proteins.SOLUTION: A method for manufacturing biologics is provided. The method comprises: culturing host cells that secrete biologics in a bioreactor; removing media and / or cell suspension from the bioreactor; processing the media and / or cell suspension to separate a filtrate containing the biologics; loading the filtrate onto at least two capture columns; eluting a first biologic product from the capture columns; loading the first biologic product onto one or more purification columns; and eluting a second biologic product from the one or more purification columns; wherein the bioreactor has a bioreactor volume, the at least two capture columns have a total capture column volume, and a ratio of the bioreactor volume to the total capture column volume is in the range of about 500:1 to about 10:1.SELECTED DRAWING: Figure 6

The present disclosure relates to compositions, methods, mixtures, and kits for detecting the presence of, and for removing, a virus from a product produced in an insect cell. The disclosure also relates to proteins, peptides, polypeptides, drug substances, biological products, vaccine antigens, and virus-like particles that are produced in an insect cell and that are free or substantially free of a virus. The disclosure also relates to compositions, methods, assays, and kits for detecting a rhabdovirus in a sample.

The technology provides systems and methods to isolate a biologic product from a process fluid by performing tangential flow filtration or a tangential flow depth filtration. The technology performs the filtration by drawing or pumping the fluid downward through the filter and controlling the flow rate such that a consistent pressure is maintained along the length of the filter.

The present invention relates to a composition comprising (poly)lysine and a mixture of lambda-carrageenan and kappa-carrageenan, wherein preferably the (poly)lysine is selected from the group consisting of alpha-poly-L-lysine, epsilon-poly-L-lysine, alpha-poly-D-lysine, epsilon-poly-D-lysine and mixtures thereof. The present invention also relates to the composition as defined above as a biocidal product and to the use of the composition as defined above for the prevention of viral infections and / or bacterial infections and / or fungal infections.

The disclosure relates to the technical field of trustworthy artificial intelligence for controlling and / or monitoring chemical and / or biological products. The disclosure relates to methods and apparatuses for determining a biological and / or chemical attribute related to sample data associated with the biological and / or chemical product.

The present invention relates to vessels for use as bioreactor, and reactor systems or apparatuses including such vessels. The vessels comprise a tank comprising a plastic or first cured resin material which is biocompatible and which can withstand steam sterilization.

The present application relates to a production facility (10) for producing a product (20), particularly a biologic product (20), the production facility having a plurality of process units (30, 50, 702, 704) for containing and / or processing an extract (40), and / or a method thereof.

Aspects of the application relate to methods, a computer program and a process control device. According to one aspect, a computer-implemented method for determining a multivariate process chart is provided. The multivariate process chart is to be used to control a process to produce a chemical, pharmaceutical, biopharmaceutical and / or biological product. The multivariate process chart includes a first trajectory, an upper limit for the first trajectory and a lower limit for the first trajectory.

A computer implemented method for controlling a synthesis process for a chemical or biological product, comprising the steps of at a processing device of a synthesis specification control module receiving via a communication interface a synthesis specification for the synthesis process, deriving a set of experimental requirements from the synthesis specification, receiving via the communication interface device laboratory equipment data associated with at least one laboratory equipment device deriving a set of equipment properties from the laboratory equipment data associated with at least one laboratory equipment device, comparing the set of experimental requirements with the set of equipment properties, generating control data based on the comparison providing with the processing device the control data suitable for controlling the synthesis process.

The invention provides tangential flow filtration systems and methods for capture and harvest of a biologic product, and related compositions.

Provided are genetically modified strains of Aureobasidium pullulans that can produce a bioproduct with increased productivity and a method of producing a bioproduct using the same, wherein the genetically modified strain of Aureobasidium pullulans comprises an overexpression of a functional VHb protein and an overexpression of a functional PacC protein and is grown under conditions required to support the production of the bioproduct to collect the bioproduct in a high yield.

The present invention discloses an antibody, biological product, nucleic acid molecule, vector, and application thereof against RSV F protein, and relates to the field of immunoassay technology. The antibody against human respiratory syncytial virus F protein provided by the present invention has high specificity and high affinity characteristics and can be used to develop corresponding biological products, such as reagents, kits, test strips, antibody chips, antibody probes, etc., in particular products for respiratory syncytial virus detection. The antibody provided by the present invention can be used in various detection methods such as ELISA detection, immunochemiluminescence detection, and immunofluorescence detection, and has the advantages of a wide range of applications and strong applicability.

Platforms, systems, and methods for multi-objective optimization and comparative analysis for synthetic biology development. According to one aspect, there is provided an AI-guided analytic platform for development of biologic synthesis processes, comprising: a multi-objective optimization system for performing multi-objective optimizations of the biologic synthesis processes; at least one multi-objective evaluation artificial intelligence model configured to evaluate a biologic product according to each of at least two objectives; and at least one variant evaluation module configured to: generate a set of variants of a biologic parent of the biologic product, and evaluate each variant of the set of variants of the biologic parent using the at least one multi-objective evaluation artificial intelligence model.

A method for obtaining secretomes from platelets and the secretome uses in regenerative medicine, in the treatment of diseases, including cell therapy, and in vitro cell culture. This method is developed with the aim of obtaining platelet-derived bio-products enriched in platelet granular cargo, rich in growth factors, and depleted of other platelet-derived molecules and plasma for universal use. The method avoids the use of platelet inhibitors or temperature-shock during the process, assuring the integrity of the platelet biological source. Furthermore, the potential processing of the product would allow additional clinical applications and solve storage limitations. This method and the characterization thereof of secretomes at the molecular level in health and disease will contribute to the identification of biomarkers for disease diagnosis and prognosis.

A consortium of engineered microorganisms for producing tryptophan-derived products and methods of using the same.