64 results about "Gastric acid" patented technology

The present invention relates to a novel pyrrole derivative compound or a pharmaceutically acceptable salt thereof. In addition, the present invention relates to a pharmaceutical composition for potassium-competitive inhibition of gastric acid secretion and a pharmaceutical composition for preventing or treating diseases caused by gastric acid secretion disorder, the pharmaceutical composition containing the novel pyrrole derivative compound or a pharmaceutically acceptable salt thereof as an active component. The pyrrole derivative compound or the like according to the present invention is a potassium-competitive acid blocker (PCAB) and has an excellent H+ / K+ adenosine triphosphatase (ATPase) (proton pump) inhibition effect, and is thus widely used as a therapeutic agent for diseases caused by gastric acid secretion disorder.

The present application relates to a kind of brain health nutrition capsule and its preparation method, belong to the technical field of functional health food.The preparation method includes the following steps: taking walnut kernel powder, DHA algal oil microcapsule powder, phosphatidylserine, ginkgo biloba extract and oligosaccharides are mixed, soft material is prepared by adding purified water, granulation is extruded by screen, and granule core is obtained by drying;Granule core is coated, and brain nutrition core granule is obtained by drying;Prepare base nutrition layer granule;Brain nutrition core granule and base nutrition layer granule are mixed, and composite granule is obtained, and composite granule is filled into capsule.The present application not only solves the three major obstacles of oxidation, precipitation and vitamin degradation of high polyphenol walnut base formula in gastric acid environment, but also unexpectedly builds from stomach protection to intestinal microecological optimization, finally realizes the cascade effect of brain nutrition efficient absorption, meets the core needs of teenagers brain health and intelligence, and truly realizes the effect of brain health and intelligence.

The present application relates to the field of pet feed, and discloses a maintenance ration formula for improving the smoothness of dog hair. The formula comprises base ration particles and lipid microcapsules attached to the surface of the base ration particles; the lipid microcapsules encapsulate a core material composed of essential fatty acids and ceramides, have a double-layer wall material structure, and the outer layer is acid-resistant plant gum and the inner layer is lipase-sensitive phospholipid; the microcapsules are attached to the surface of the puffed base ration by low-temperature vacuum spraying. The present application makes the microcapsules resistant to gastric acid and releases the core material under the action of duodenal lipase, targets and enriches in sebaceous glands through the lymphatic system, solves the problems of low lipid delivery conversion rate and insufficient substrate of sebaceous glands, improves the proportion of sebaceous gland ceramides, and reduces the hair friction coefficient.

The application discloses a kind of biological hybrid micro machine population oral delivery system of imitating Helicobacter pylori survival mechanism, belong to oral stomach medicine delivery technical field.The system is by active power module (flagellum driven chlamydomonas reinhardtii), environmental regulation module (acid urease modified on algal surface) and multifunctional load module (macrophage membrane wrapped drug-loaded nanoparticles) synergistic assembly through polydopamine (PDA) spatial conformation control layer is formed.Active power module utilizes self-movement ability to penetrate mucus barrier and extend intracavity retention time to 12 hours or more;Environmental regulation module produces local alkalization effect by catalyzing urea hydrolysis, provides chemical shield for system in extremely acid environment of pH 1.0-3.0, protects active power module from gastric acid inactivation;Multifunctional load module is accurately delivered to gastric epithelial cells by inflammation targeting effect, such as CRISPR / Cas9 biological macromolecule, and realizes up to 31.8% in-vivo gene editing efficiency.The application provides a non-invasive, modular active delivery platform for the precise treatment of gastric diseases such as gastritis through the synergistic effect of physical penetration, metabolic reprogramming and gene intervention.

This invention discloses a single-herb bezoar preparation based on an ancient prescription; an enteric-coated bezoar soft capsule and its preparation method. The enteric-coated bezoar soft capsule consists of a bezoar dispersion and an enteric-coated soft capsule shell. A sand mill is used to prepare bezoar powder into micron-sized particles with a particle size ≤100μm. The micron-sized bezoar powder is fully dispersed in a dispersion medium, thereby improving the solubility of bezoar. The single-herb bezoar preparation can improve the problem of inconsistent bezoar content in compound bezoar preparations. The process of preparing the ≤100μm micron-sized bezoar dispersion uses non-metallic grinding equipment, avoiding the catalytic reaction of metal ions during the preparation of micron-sized powder. Low-temperature grinding is also used to avoid denaturation of the heat-sensitive active substances in bezoar, better preserving its biological activity. The enteric-coated formulation prevents the drug from being released in the stomach until it reaches the small intestine, avoiding the precipitation of bilirubin and other bile acids in the acidic environment of the stomach, which would otherwise lead to insoluble solids and poor solubility.

This invention discloses a highly acid-resistant Bacillus belye strain LYBV022-Ac R This invention relates to a method for screening and acclimating bacteria under progressive acid stress, and its application, belonging to the technical field of industrial microbial breeding and probiotic application. The disclosed high-acid-resistant Bacillus belyeis LYBV022-Ac... R By designing a pH gradient decreasing (6.5→3.0) acclimatization strategy and combining it with microplate rapid screening technology, a breakthrough improvement in acid resistance was achieved. After exposure to a simulated gastric acid environment (pH 3.0, containing pepsin) for 4 hours, the survival rate reached 48.52%, a 970-fold increase compared to the original strain (0.05%), while maintaining excellent growth performance and genetic stability. This invention also provides the application of this strain in the preparation of oral probiotic preparations for livestock and poultry, solving the common technical problem of insufficient potency in oral Bacillus preparations due to gastric acid damage.

This invention discloses an environmentally friendly curcumin nanocrystal and its preparation method, relating to the field of nanoparticle technology. The nanocrystal has a core-shell structure, with a core of curcumin crystals and a shell of hepatin peptide molecules bonded together by intermolecular forces. The average particle size of the nanocrystal is 50-200 nanometers, and it is completely dispersed and stable in an aqueous phase, containing no organic solvents or synthetic surfactants. This invention utilizes a pectin-chitosan complex to microencapsulate the nanocrystal, enabling it to resist gastric acid degradation and target release to the colon, thus precisely acting on the gut-hepatic axis and significantly improving bioavailability and hepatoprotective efficacy. While completely avoiding organic solvents and synthetic stabilizers, it simultaneously solves four major industry challenges related to curcumin: solubility, stability, targeted delivery, and synergistic efficacy, providing a new technical path for developing high-end, naturally derived hepatoprotective products.

The present application relates to the field of food technology, and specifically discloses a composition for reducing gastroesophageal reflux in individuals, a preparation method and application thereof. The composition for reducing gastroesophageal reflux in individuals comprises beta-defensin 1, lysozyme and lactoperoxidase. The present application constructs a multi-target synergistic intervention mechanism combining physical protection, secretion regulation and tissue repair through the compounding of four core components, which can comprehensively block the occurrence and development of gastroesophageal reflux. Lactadherin constructs a physical barrier to reduce the risk of reflux dynamics from the source; MLCT precisely regulates gastric acid secretion to reduce chemical stimulation; HMO complex IgG strengthens the mucosal immune barrier and promotes damage repair. The above composition is applied to products for reducing gastroesophageal reflux in individuals, and multi-target synergistic effect is achieved, realizing a full-chain closed-loop intervention from prevention, relief to repair, and significantly improving the clinical improvement effect.

This application discloses a glycoside nutritional supplement microcapsule and its preparation method. The method first prepares an oil phase by combining the glycoside active ingredient, a bioavailability enhancer, and an amphiphilic carrier material, and a pre-emulsion aqueous phase by preparing an emulsifier. The pre-emulsion is then formed through microfluidic emulsification. Next, the pre-emulsion is layered and assembled with a shell aqueous phase containing a gastric acid-resistant film-forming material and intestinal flora-responsive polysaccharides in a subsequent coaxial channel to obtain precursor-encapsulated particles. These particles are then electrostatically sprayed into an inorganic salt curing bath for interfacial ionic cross-linking and curing to form wet microcapsules. Finally, the microcapsules are freeze-dried and induced by a high-voltage electric field to obtain the glycoside nutritional supplement microcapsules. This method helps improve the dispersion stability, encapsulation integrity, and storage stability of the glycoside active ingredient, enhances its protective effect in the gastric environment, and promotes its gradual release and absorption in the intestinal environment. It is suitable for oral delivery of glycoside nutritional supplements and improves overall oral utilization efficiency.

The application belongs to the technical field of biological medicine, and specifically discloses a nano delivery system and a preparation method and application thereof. mEVs are used as a core to encapsulate a depressor peptide QIGLF, a positively charged K5 is used to form an intermediate layer, the structural stability of the system is enhanced, and cell uptake is promoted, finally, a negatively charged Pec is used to form an outer protective shell, the stability and anti-enzymatic ability of the nanoparticles in the gastrointestinal environment are improved, and a core-shell multi-layer structure is constructed. The Pec can remain stable in the gastrointestinal tract, resist the destruction of gastric acid and digestive enzymes, and realize the responsive release of the core and the depressor peptide through specific degradation of the intestinal flora in the colon environment, and the K5 further enhances the uptake of the nanoparticles by the colon epithelial cells, thereby ensuring the efficient absorption of the depressor peptide. The nano delivery system has the comprehensive advantages of structural stability, intestinal retention, colon targeting and biological functionality during oral delivery, and provides an innovative solution for the efficient and safe application of the oral depressor peptide.

The application belongs to the technical field of microbial preparation, and specifically discloses a kind of SA-MPN encapsulated bacteriophage preparation and its preparation method and application, its preparation method includes the following steps: take bacteriophage cocktail concentrate, add tannic acid solution, FeCl3·6H2O solution, phosphate buffer solution, obtain metal phenolic aldehyde network encapsulated bacteriophage;Subsequently, CaCl2 solution and sodium alginate solution are added to the metal phenolic aldehyde network encapsulated bacteriophage in sequence, to obtain sodium alginate-metal phenolic aldehyde network-bacteriophage mixture microcapsules.The application adopts the above-mentioned SA-MPN encapsulated bacteriophage preparation and its preparation method and application, which can effectively protect bacteriophage from gastric acid, high temperature and ultraviolet stress, realize intestinal targeting and slow release, has high encapsulation efficiency, good stability, antioxidant activity, significant antibacterial effect on salmonella and high biological safety.

This invention relates to the field of microcapsule preparation, specifically to an ultrasound-assisted pH-responsive method for preparing malkiberry anthocyanin microcapsules, comprising the following preparation steps: S1: core material preparation; S2: wall material preparation; S3: oil phase preparation; S4: aqueous phase preparation; S5: ultrasonic emulsification; S6: solidification; S7: separation and washing; S8: drying and temperature control. This invention selects a specific combination of wall materials that are stable in gastric acid and can responsively dissociate or swell under intestinal pH conditions. Using ultrasound-assisted preparation technology, malkiberry anthocyanin microcapsules are prepared through cavitation and mechanical effects. Furthermore, the temperature is controlled below 30°C during the preparation process. The resulting microcapsules achieve an encapsulation rate of 68%–75%, effectively protecting the malkiberry anthocyanins from the gastric acid environment and enabling pH-responsive release in the intestine. This significantly improves the stability and oral bioavailability of malkiberry anthocyanins, demonstrating broad application prospects.

The embodiment of the application discloses an acid-responsive oxygen-releasing chitosan / polycaprolactone core-shell microsphere and a preparation method and application thereof. The microsphere comprises an oxygen-releasing inner core taking polycaprolactone and calcium peroxide as base materials, and a pH-responsive outer shell modified by chitosan through N-acetyl-d-glucosamine and loaded with a natural medicine 6-Gin; the microsphere is disintegrated in the outer shell under the gastric acid environment and rapidly releases 6-Gin, and the inner core continuously releases oxygen by reacting with water. The microsphere provided by the application can effectively inhibit bacterial adhesion, destroy a biofilm and directly kill H. pylori, and solves the problem of poor curative effect caused by a microenvironment in traditional therapy, and provides a new effective strategy for anti-H. pylori therapy.

The application discloses a drug delivery system for remodeling intestinal uric acid homeostasis and a preparation method, a pharmaceutical composition and an application thereof, and belongs to the field of biomedical technology. The drug delivery system comprises a probiotic active biological carrier with autonomous movement capability, the surface of the probiotic active biological carrier is loaded with uricase and peroxidase-like active nanoscale enzyme through electrostatic interaction, and the probiotic active biological carrier is externally coated with a pH-responsive protective shell. The uricase catalytically degrades intestinal uric acid, the nanoscale enzyme synchronously removes hydrogen peroxide byproducts to maintain catalytic stability, and the shell protects the active ingredients in gastric acid and realizes targeted release and long-term retention in the intestine by responding to dissociation. Moreover, the drug delivery system has high targeting property, high safety and can efficiently remodel intestinal uric acid homeostasis.

The application discloses a drug-loaded microalgae motor system for colon-targeted delivery and a preparation method and application thereof. The drug-loaded microalgae motor system comprises a Chlamydomonas reinhardtii microalgae motor core, the surface of the core is adsorbed with amino-modified ferroferric oxide nanoparticles through electrostatic adsorption, is wrapped with quercetin-modified chitosan quaternary ammonium salt, forms a nano-composite with magnetic responsiveness, and is encapsulated in a sodium alginate microsphere. The application utilizes Chlamydomonas reinhardtii as an antioxidant for adjuvant therapy, in a colon environment, the sodium alginate microsphere can be degraded in response to specific conditions, release the microalgae motor to autonomously move in intestinal fluid, and under the guidance of an external magnetic field, precisely target a lesion site in the intestinal tract. The application has good biocompatibility, biodegradability, gastric acid avoidance ability and magnetic / chemical dual driving targeting function, can effectively improve the treatment effect on colon diseases, and significantly reduce the systemic side effects of drugs, and expands the application of micro / nano motors in the biomedical field.

This invention discloses a strain of *Bacillus belyceae* with broad-spectrum antibacterial activity and its application in the prevention and treatment of necrotic enteritis in poultry. The *Bacillus belyceae* strain provided by this invention (… Bacillus from Velez The genome of strain GDG25CB056 is approximately 3.91 Mb in size, contains no virulence factors, and is rich in gene clusters encoding non-ribosomal peptides and polyketide synthases. Studies have confirmed that this strain exhibits significant growth advantages, strong tolerance to high temperatures, gastric acid, and bile salts, which facilitates intestinal colonization. It can produce siderophores and various enzymes, and has overcome the technical bottleneck of a narrow antibacterial spectrum, possessing broad-spectrum antibacterial activity, especially strong specific antagonistic activity against Clostridium perfringens. In vivo experiments have shown that this strain can significantly reduce the Clostridium perfringens load in the cecum of chicks with necrotizing enterocolitis, alleviate intestinal congestion and swelling, repair damaged intestinal villi, and enhance mucosal barrier function, providing a safe and efficient strain resource for the prevention and treatment of bacterial enteric diseases.

The utility model discloses a probiotic tablet with multilayer protection slow -release structure, including tablet main part, four enteric layers are established with the center symmetry on the tablet main part, the embedding layer one is equipped with in the enteric layer, the embedding layer two is equipped with in the embedding layer one, the probiotic core is equipped with in the embedding layer two, the embedding layer two and embedding layer one between, embedding layer one and enteric layer between all are equipped with the isolation layer between the probiotic core and embedding layer two, the tablet main part center is seted up and has the inner through -opening. This probiotic tablet with multilayer protection slow -release structure sets up enteric layer, embedding layer one and embedding layer two outside the probiotic core, can guarantee this probiotic tablet safe through gastric acid through enteric layer, greatly reduce the killing of gastric acid to probiotic, and embedding layer one and embedding layer two adopt different vitamin constitution, under the condition that can increase the additional efficacy of probiotic tablet, slow down the release of probiotic, to guarantee the survival amount of probiotic in the intestines.

The application provides a high-temperature-resistant and gastric acid-resistant probiotic preparation and a preparation method thereof, and the preparation comprises a probiotic core layer and a shell layer covering the same, and the shell layer comprises succinyl-modified food leaf protein assisted by ultrasonic pretreatment, peach gum polysaccharide and soybean lecithin. The application constructs a single-layer protection system with excellent responsiveness by performing specific functional modification on the food leaf protein and synergizing the food leaf protein with the peach gum polysaccharide and the soybean lecithin. The preparation can significantly improve the survival rate of probiotics during processing, storage and simulated gastrointestinal digestion, and especially realizes excellent gastric acid resistance and intestinal targeting release performance, and the process is simple and suitable for embedding and protecting various probiotics.

This invention relates to an ionic amphiphilic bioporphyrin, its preparation method, and its application, belonging to the field of pharmaceutical technology. The preparation method of the ionic amphiphilic bioporphyrin of this invention includes the following steps: stirring and reacting heme with an alkaline solution to obtain a dispersion; adding an acidic solution to the obtained dispersion to adjust the pH to 4-11, thereby obtaining the ionic amphiphilic bioporphyrin. This invention combines the ionized modified amphiphilic bioporphyrin with alkaline excipients and prepares it into an enteric-coated capsule dosage form, ensuring its stability in gastric acid. Upon reaching the intestine, it achieves effective release and creates a suitable alkaline microenvironment for the dissolution of ionic heme, thereby improving the solubility of heme derivatives in the intestine and oral uptake efficiency.

Amorphous solid dispersions and pharmaceutical compositions of the protein kinase inhibitor dasatinib. The pharmaceutical compositions may be used in methods of treating a proliferative disorder such as cancer, or in methods of delivering dasatinib to patients without regard to whether the patient is concurrently administered a gastric acid-reducing agent, or without regard to whether the patient has an elevated gastric pH. The compositions may be particularly suitable for patients afflicted by achlorhydria or hypochlorhydria, or Helicobacter pylori infection.

This invention discloses a method for preparing an oral nanoparticle formulation of apigenin, belonging to the field of traditional Chinese medicine preparation technology. The method uses a mixture of soybean protein and xylan as the aqueous phase and an apigenin ethanol solution as the organic phase. Nanoparticles are prepared by antisolvent precipitation, followed by adsorption of tannic acid to obtain the final product. The nanoparticles prepared by this invention have a particle size of less than 600 nm and a high encapsulation efficiency. Utilizing the synergistic effect of soybean protein, xylan, and tannic acid, apigenin is protected from gastric acid degradation, achieving targeted intestinal delivery and significantly improving its oral bioavailability. This method can be used to prepare drugs for treating intestinal diseases such as inflammatory bowel disease, irritable bowel syndrome, or colorectal cancer.

The application discloses a kind of complex probiotics and plant extract synergistic additive for no-antibiotic breeding, and relates to the technical field of animal feed additives.The present application comprises complex probiotics, synergistic plant extract, synergistic carrier and stabilizing protective agent.The present application realizes the physical isolation of probiotics and plant extract by intercalation of nano montmorillonite and extract of goldthread, eucommia ulmoides, rosemary and cinnamon and microcapsule embedding, to avoid direct contact inhibition;Through double-layer microcapsule and low-temperature blending process, the sealed survival rate can be greatly improved, and it has high stability;Nano-emulsification improves the bioavailability of plant extract and reduces the direct contact inhibition of probiotics;Double-wall material microcapsule protects probiotics from passing through gastric acid environment, and releases low-temperature blending in the intestinal target to avoid activity loss, and the product storage stability is better than existing preparations.

The application provides a preparation method of a biomineralization coated bacterium, the biomineralization coated bacterium and application thereof, and relates to the technical field of microbial medicine preparation.The preparation method of the biomineralization coated bacterium comprises the following steps: mixing bacteria and a polyvinylpyrrolidone solution to obtain a bacterium suspension; mixing a CaCl2 solution with the bacterium suspension, and then adding an Na2CO3 aqueous solution; stirring for 0.5-1.5 hours, centrifuging, collecting the precipitate and obtaining the biomineralization bacterium. The method is simple and convenient, and is used for assisting biological interface mineralization through electrostatic interaction to deposit a super-resistant and self-adapting bacterium protection coating. The method is universal for coating various species including obligate and facultative anaerobes. The preparation procedure and the formed coating have negligible influence on the activity of the bacterium, and the bacterium is free from the double invasion of gastric acid and bile acid, so that the activity and quantity of the bacterium reaching the intestinal tract are ensured.

The application provides a double-layer slow-release feed antioxidant based on superfine ginger powder and a preparation method thereof. The ginger powder is crushed to superfine particle size through a superfine crushing technology, the cell wall barrier is broken, and the dissolution efficiency and bioavailability of active ingredients are improved. The chitosan is modified by using a silane grafting modification technology, an inner layer coating with excellent hydrophobicity, water resistance and mechanical strength is constructed, a hydrophilic outer layer coating is constructed in combination with sodium alginate, a double-layer coating structure of "inner hydrophobic-outer hydrophilic" is formed, the protection of active ingredients such as gingerols in a gastric acid environment and the targeted slow release in an intestinal environment are realized, meanwhile, the palatability and storage stability of the product are improved by reasonably matching the components, and finally, a safe, efficient, stable and controllable natural feed antioxidant is obtained, technical defects existing in the prior art ginger powder feed antioxidant are solved, and the demand of large-scale livestock and poultry breeding is met.

This invention relates to the field of biomedical technology, and more particularly to a fenelazol microsphere, its preparation method, and capsules. This invention optimizes the formulation of the original fenelazol tablets, using blank pellet cores as a carrier, sodium carbonate as an alkalizing agent, and sulfobutyl-β-cyclodextrin as an excipient to prepare fenelazol microsphere capsules. Experiments show that these microspheres have excellent solubility in gastric acid, are pH-independent, and exhibit high long-term storage stability. This invention simplifies the production process, has good process stability, low production costs, and is suitable for large-scale production.

This invention discloses a method for preparing nattokinase enteric-coated sustained-release capsules and sustained-release gel spheres, belonging to the field of sustained-release microcapsules. This invention improves the selection of wall materials and the preparation process, encapsulating nattokinase using a mixture of food-grade enteric-coating shellac and whey protein isolate as the wall material. After spray drying, food-grade enteric-coated microcapsules are obtained. These microcapsules are then embedded in calcium alginate gel, forming enteric-coated gel spheres through stepwise encapsulation. The gel spheres prepared by this invention are safe for consumption, have a high encapsulation rate, are resistant to gastric acid, can be released into the intestines, are easy to store and transport, and can be mass-produced industrially.

The present application relates to the technical field of probiotic preparation, and particularly relates to a gastroenteric probiotic granule and a preparation method and application thereof, the coated granule comprises: a probiotic core material, and a coating layer coated outside the core material; the coating layer is formed by a composite coating material of hydrogenated palm oil and stearic acid surface modified nano active calcium carbonate, wherein the stearic acid surface modified nano active calcium carbonate accounts for 50% to 60% of the total mass of the composite coating material, and the weight ratio of the coating layer to the core material is 20% to 25%. The present application utilizes hydrogenated palm oil to form a hydrophobic physical barrier, and simultaneously utilizes nano calcium carbonate to slowly neutralize acidity in gastric acid, generate bubbles to form a microenvironment buffer, and realize a dual synergistic protection mechanism of physical barrier and chemical buffer. In vitro tests show that the probiotic granule prepared by the present application has a survival rate of greater than or equal to 90% after being treated in artificial gastric juice for 2 hours, and a release rate of greater than or equal to 93% after being treated in artificial intestinal juice for 2 hours, which is significantly better than traditional coating technology, and has a broad industrial application prospect.

The present application relates to a kind of based on selective permeable membrane and 3D printing porous carrier large intestine targeted bacteria-loaded pellets, belong to oral large intestine targeted drug delivery technical field, and large intestine targeted bacteria-loaded pellets are obtained by mixed bacteria body being wrapped by semi-permeable shell membrane as shell, the semi-permeable shell membrane is obtained by selective permeable membrane covering 3D printing porous carrier, and the 3D printing porous carrier is used as support skeleton.By mixed bacteria body being wrapped by semi-permeable shell membrane as shell, the semi-permeable shell membrane is obtained by selective permeable membrane covering 3D printing porous carrier, selective permeable membrane is evenly coated on the outer surface and pore inner wall of 3D printing porous carrier, and together form the shell with mechanical strength and large intestine targeted permeability, so that large intestine targeted bacteria-loaded pellets, release rate 3-4% in simulated gastric acid 2 hours, can effectively protect the safety of internal embedded flora through stomach, after entering intestine, release rate 94-96% in 4 hours in large intestine simulation liquid, and cumulative total release rate is as high as 97-99%.