646 results about "Gastric acid" patented technology

The invention relates to the technical field of biological medicines, and discloses a high-activity lactobacillus rhamnosus probiotic microcapsule, which comprises the following components in parts by weight: lactobacillus rhamnosus: each gram of formula contains 1010 CFU; bifidobacterium: each gram of the formula contains 109 CFU; 10% to 20% of sodium alginate; 5%-15% of chitosan; 3%-8% of hydroxypropyl methyl cellulose; 3%-7% of pectin; 5% to 10% of fructo-oligosaccharide; 5%-10% of inulin; 0.1%-0.5% of vitamin C; and 0.1%-0.3% of vitamin E. Through double-layer and three-layer embedding technologies (such as compound use of sodium alginate and chitosan and compound use of pectin and gelatin), the tolerance of the probiotics in gastric acid and bile environments is remarkably improved, the probiotics are effectively protected through a multi-layer embedding structure, the survival rate of the probiotics in the gastric environment reaches up to 90%, and the release rate in the small intestine exceeds 75%.

The invention relates to the technical field of microorganisms, in particular to plant lactobacillus MPs-68 capable of adsorbing microplastics and degrading uric acid and application of the plant lactobacillus MPs-68. The provided plant lactobacillus MPs-68 capable of adsorbing microplastics and degrading uric acid is a marine-derived natural strain, the preservation number is CGMCC No.31976, the plant lactobacillus MPs-68 has a remarkable adsorption effect on microplastics polystyrene and polyethylene, has the function of degrading uric acid, and is high in oxidation resistance, gastric acid resistance, cholate resistance and intestinal colonization capacity, and the plant lactobacillus MPs-68 can be used for adsorbing microplastics and degrading uric acid. The method has important application value in the fields of food or health care products for assisting adsorption of micro-plastics and reduction of uric acid and the like. The invention also provides a microbial agent, a probiotic product, a functional food, a fermentation product, a microecological preparation, a microplastic adsorbent and a microplastic adsorbent compounded with the lactobacillus brevis MPA01 (the preservation number is CGMCC No.31977) containing the phytobacterium plantarum MPs-68 capable of adsorbing the microplastics and degrading the uric acid, and the microplastic adsorbent has the effects of adsorbing the microplastics, degrading the uric acid and the like.

The invention relates to the field of microorganisms, and discloses lactobacillus plantarum with an antibacterial effect and application of the lactobacillus plantarum, and the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) No.33151. The strain provided by the invention has relatively strong cholate resistance, gastric acid resistance, acid production and H2O2 production capabilities, and has a relatively strong bacteriostatic effect on common pathogenic bacteria such as staphylococcus aureus, candida albicans, escherichia coli, salmonella and helicobacter pylori; the compound can inhibit the activity of urease, interfere helicobacter pylori colonization and the like to inhibit helicobacter pylori infection or reduce the symptoms of helicobacter pylori infection and reduce the disease degree of mice with colitis, can be used for preparing microbial preparations, and has the potential of preparing drugs for preventing and / or treating diseases caused by helicobacter pylori infection.

The invention provides a probiotic enteric dry suspension as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations. The probiotic enteric dry suspension comprises the following components in parts by mass: 1-8 parts of probiotic powder; 25 to 60 parts of a microcapsule cross-linking system; 1-15 parts of a suspending aid; 20 to 70 parts of a filling agent; 0-0.1 part of a coloring agent; and 0-1 part of an aromatic. According to the invention, when the probiotic powder is dispersed in water by utilizing the gelling property of sodium alginate, the probiotic powder is wrapped to form a probiotic-sodium alginate compound, citric acid and calcium carbonate are subjected to an acid-base reaction, and generated carbon dioxide bubbles can prevent the probiotic-sodium alginate compound from agglomerating; meanwhile, the released calcium ions and chitosan interact with the probiotic-sodium alginate compound, a compact probiotic microcapsule structure is rapidly and stably formed in one step, the probiotics in the microcapsule are effectively protected from being damaged by gastric acid and bile, the survival rate of the probiotics is increased, and the enteric effect is achieved.

The invention discloses a vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions and a preparation method and application thereof, the vitamin K2 composite micro-capsule system with stomach protection and intestine slow release functions comprises three layers, namely a core layer, a middle layer and an outer layer from inside to outside in sequence; the core layer is formed by coating vitamin K2 with a zein-lac hydrophobic core, the middle layer is a pea protein-pectin electrostatic compound, and the outer layer is sodium alginate and chitosan double-network gel. The micro-capsule system provided by the invention can be tightly combined in a gastric acid environment after being orally taken, the release of active ingredients in the stomach is reduced, and then the micro-capsule system stays at intestinal mucosa for a long time and slowly releases contents, so that the functions of the micro-capsule system are slowly presented outside, the half-life period is prolonged, and the action effect is improved. Vitamin K2 directly or indirectly participates in and regulates various physiological processes related to health, and plays an important role in the aspects of maintaining bone health, preventing cardiovascular diseases, protecting nerves, improving metabolism and the like.

The invention discloses a hydrogel patch for gastric perforation repair and a preparation method thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: dissolving acryloyl valine, acrylic acid, methylene bisacrylamide, a compound A and a photoinitiator in an alcohol solvent, and defoaming to obtain a precursor solution; and placing the precursor solution in a mold, carrying out ultraviolet-induced curing, soaking the obtained hydrogel in a hydrochloric acid solution, and replacing the alcohol solvent to obtain the hydrogel patch for gastric perforation repair. The hydrogel patch provided by the invention has the advantages of strong acid corrosion resistance, good biocompatibility, low swelling ratio, stable adhesion performance in a fluctuating pH environment and the like. The tough and stable adhesion performance ensures that the hydrogel can be permanently and reliably adhered to a gastric perforation part in a dynamic gastric acid environment, and a stable platform is provided for drug delivery, so that the surgical operation time is expected to be shortened, and wound healing is promoted.

The invention belongs to the technical field of microorganisms, and particularly relates to bifidobacterium longum subsp. Longum as well as a composition, a pharmaceutical composition, a culture, a food product or a dietary supplement containing the bifidobacterium longum subsp. Longum and application of the bifidobacterium longum subsp. Longum. The bifidobacterium longum is preserved in the Guangdong Microbial Culture Collection Center on January 21, 2025, and the preservation number is GDMCC (China General Microbiological Culture Collection Center) No.65836. The bifidobacterium longum subsp. Longum has relatively strong gastric acid and cholate tolerance and intestinal colonization capability; the bifidobacterium longum subsp. Longum can effectively utilize bifidobacterium bifidum to release monosaccharide or disaccharide outside cells for efficient proliferation, and the composition containing the bifidobacterium longum subsp. Longum, the bifidobacterium bifidum and breast milk oligosaccharide can release a large amount of short-chain fatty acid, so that the effects of maintaining the physiological function of an organism and improving the health of the organism are achieved.

The invention discloses construction and application of an oral gel drug delivery system based on a yeast microcapsule, and belongs to the field of new auxiliary materials and new dosage forms of pharmaceutical preparations, the drug delivery system is composed of budesonide nanoparticles, the yeast microcapsule and gel, budesonide nanoparticles are prepared from budesonide and a polylactic acid-glycolic acid copolymer through a water-in-oil emulsification evaporation technology, yeast cell wall microcapsules are formed after content of yeast powder is removed, and the budesonide-loaded yeast microcapsules are prepared from the yeast microcapsules and the budesonide nanoparticles through stirring, ultrasonic treatment and freeze drying methods. The yeast cell wall microcapsule without contents is used as a carrier, so that the medicine is protected from being degraded by gastric acid, and the intestinal immune response is regulated by targeting intestinal related lymphatic tissues (GALT). The gel prepared by combining pectin can prolong the residence time of the drug in the intestinal tract, realizes continuous release, reduces the whole-body side effect of budesonide, and improves the treatment efficiency.

The invention discloses a compound feed for raising plateau live pigs and a preparation method thereof, and relates to the technical field of feed processing. The compound feed for raising the plateau live pigs is prepared from manganese-selenium compound modified charcoal, soybean polysaccharide polylysine-based supported nanoparticles, aspergillus oryzae, soybean meal powder, corn flour, wheat bran, mountain flour, calcium hydrophosphate, table salt and multivitamins. Manganese-selenium composite modified charcoal, soybean polysaccharide polylysine-based supported nanoparticles and aspergillus oryzae are subjected to co-fermentation culture to form a uniform, stable, loose and porous three-dimensional network fermentation substrate composite system, so that the damage of gastric acid to components is reduced, the targeted release of intestinal tracts is realized, and the bioavailability is improved. The composite functional additive which is high in nutrition, easy to absorb, anti-oxidation, anti-anemia, anti-ultraviolet radiation and the like is obtained, and the adverse effects of low temperature, oxygen deficit and ultraviolet factors on animal growth and feed oxidative rancidity are effectively reduced.

The invention relates to the technical field of biological medicine, and discloses a formula of compound probiotic enzyme powder for promoting gastrointestinal microecological balance and nutrient absorption, by constructing a cross feeding system of bifidobacteria, lactobacillus and butyric acid bacteria and combining a stomach-intestine stage enzyme activity gradient adaptation strategy and a microenvironment response type double-layer embedding technology, the gastrointestinal microecological balance and nutrient absorption can be promoted, and the gastrointestinal microecological balance and nutrient absorption can be promoted. And cross-scale synergy of flora metabolism, substrate conversion and targeted release is realized. Wherein the sodium alginate-pectin composite embedding structure forms a pH buffer micro-area in a gastric acid environment, and proton pump gene expression of the acid-resistant strain is synchronously triggered; the prebiotics compounding and step-by-step enzymolysis process breaks through a closed-loop path of fiber degradation-flora proliferation-short-chain fatty acid generation. Compared with a traditional single-strain intervention scheme, the method has the advantages that double limitations of flora function splitting and process isolation are broken through, and systematic technical advantages are formed in the aspects of improving flora colonization stability, enhancing metabolite conversion efficiency and inhibiting pathogenic bacterium colonization.

The Lactobacillus plantarum VB165 strain, which was collected in the China General Microbiological Culture Collection Center on 28 September 2022 under preservation number CGMCC NO. 25839. When simulating in intestinal environment, the strain can inhibit the activity of α-glucosidase, can degrade bile salts, inhibits the activity of primary pathogenic gut bacteria, and possesses good tolerance to gastric acid and choline; said strain can be applied in the preparation of products to control blood glucose.

The invention discloses a bacillus coagulans feed additive and a preparation method thereof, and relates to the technical field of feed additives, the bacillus coagulans feed additive comprises bacillus coagulans spores, the content of the spores is 1.0 * 10 < 8 >-1.0 * 10 < 11 > CFU / g; the protective agent system comprises the following components: maltodextrin or lactose, vegetable protein, polyhydric alcohol and an antioxidant; the invention discloses a microcapsule coating structure. A microcapsule is a two-layer composite coating of an inner layer alginate matrix and an outer layer polycation or polymer coating. According to the invention, bacillus coagulans spores which can still keep high survival rate under short-time high-temperature and low-pH conditions are obtained through screening and fermentation strategies of strains with high sporulation and heat and acid tolerance, the problem that common strains are easy to inactivate in granulation, extrusion and gastric acid environments is solved, the problem of product failure caused by insufficient tolerance of the strains is reduced, and the product quality is improved. And the original biological activity basis is improved, so that the protection effect of the subsequent formula and the coating can be played at a higher starting point, and the zoology effect of the final preparation is improved.

The invention provides a lactobacillus plantarum VB165, which is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on September 28, 2022, and the preservation number is CGMCC NO.25839. The lactobacillus plantarum VB165 is named as VB165. The lactobacillus plantarum VB165 has the advantages that the lactobacillus plantarum VB165 is named as VB165; under the condition of simulating the intestinal environment, the strain can inhibit the activity of alpha-glucosidase, also has the activity of degrading cholate and inhibiting main intestinal pathogens, has good tolerance to gastric acid and choline, and can be applied to preparation of blood sugar control products.

The invention discloses a preparation method and application of pH-responsive double-synergistic-therapy hydrogel. The hydrogel is mainly prepared from oxidized fucoidin (OFU), carboxymethyl chitosan (CMCs), zinc peroxide / copper nanoparticles (ZnO < 2-Cu >) and arginine (L-ARG). Under a gastric acid condition, the hydrogel generates H2O2 through zinc peroxide, copper ions catalyze H2O2 through a Fenton-like reaction to generate OH <->, arginine can catalyze H2O2 to generate NO, and the copper ions and the arginine act together to destroy a helicobacter pylori biological membrane and kill bacteria. The hydrogel has good injectability, self-healing property and adhesivity, is beneficial to intragastric injection application and can be adhered to the stomach, and the administration concentration of an infected part is improved; the antibacterial effect is generated only under the gastric acid condition, the helicobacter pylori biological membrane can be destroyed, and the helicobacter pylori antibacterial agent can be applied to the helicobacter pylori which is difficult to eradicate in the stomach of the human body.

The invention relates to a plant lactobacillus with effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus. The plant lactobacillus is a plant lactobacillus BGI-J9 strain, and the preservation number of the plant lactobacillus is CCTCC NO: M 20242630. The invention further discloses a preparation method of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness and application of the plant lactobacillus with the effects of dispelling effects of alcohol, protecting the liver and restoring consciousness. The strain has excellent tolerance to gastric acid, intestinal juice and cholate in a gastrointestinal tract system, can survive in the gastrointestinal tract, and provides a basis for continuously playing a probiotic effect; the compound has excellent inhibition capability on common intestinal pathogens; free radicals can be removed, and oxidative damage to the body is reduced; good alcohol metabolism enzyme synthesis capability and alcohol metabolism promoting potential are realized; the strain also has an excellent improvement effect on alcohol-damaged mice, specifically, the metabolism of ethanol and acetaldehyde in a body is accelerated, the occurrence time of drunkenness is obviously delayed, and the sobering time is shortened; intestinal injury and systemic inflammation caused by alcohol are improved; liver oxidative stress caused by alcohol is improved, and the occurrence and development process of alcoholic fatty liver is delayed; and cognitive function impairment caused by alcohol is improved.

The invention belongs to the technical field of drug delivery, and particularly relates to a multi-response colitis disease targeting hydrogel microsphere as well as a preparation method and application thereof. The hydrogel microsphere comprises a calcium ion cross-linked sodium alginate microsphere and HA-Cys / Cur NPs which is encapsulated in the calcium ion cross-linked sodium alginate microsphere, the preparation method comprises the following steps: self-assembling cysteine ethyl ester modified hyaluronic acid and curcumin to form nano-particles, encapsulating HA-Cys / Cur NPs into sodium alginate microspheres by an emulsification method, and carrying out calcium ion crosslinking, so as to obtain the hydrogel. The hydrogel microspheres have pH and GSH response characteristics and hyaluronic acid-mediated active targeting capability, are stable in a gastric acid environment, are accurately released at a colon part and target macrophages at an inflammation part, and NPs disconnects disulfide bonds and releases curcumin in an intracellular high GSH environment, so that synergistic treatment of anti-inflammation, anti-oxidation and intestinal mucosa repair is realized, and the curative effect is good. The medicine has a good application prospect in treatment of ulcerative colitis.

The invention belongs to the technical field of nano material synthesis, and particularly relates to baicalein-copper nano microgel as well as a preparation method and application thereof. According to the invention, copper ions and baicalein are coordinated to form nanowires, and the nanowires are coated with hyaluronic acid (HA) to prepare the nano microgel. The method is carried out at normal temperature, is simple in process and high in yield, and does not need toxic solvents; the obtained microgel has high stability (gastric acid resistance), targeted delivery (CD44 receptor mediation) and multiple biological activities (oxidation resistance and inflammation resistance). Animal experiments show that the pharmaceutical composition can significantly relieve ulcerative colitis, the dosage is as low as 5 mg / kg, the pharmaceutical composition is non-toxic, and a new strategy is provided for treatment of inflammatory diseases.

The invention relates to a whole intestine flora transplantation strategy and a nanometer packaging method and application thereof. According to the method disclosed by the invention, the transplantation of the whole intestinal flora is realized by mainly utilizing the combined transplantation of the intestinal fluid flora and the fecal flora, so that the micro-ecology of the whole intestinal tract is more comprehensively, accurately and efficiently regulated and controlled, and a better flora transplantation treatment effect is achieved. The microflora (microcapsules) is encapsulated by a safe biological material, the encapsulating process is simple in process and short in time consumption, intestinal bacteria in different shapes can be simultaneously encapsulated, and the method is not only suitable for encapsulating oxygen-resistant bacteria and facultative anaerobic bacteria, but also suitable for encapsulating intestinal flora including strict anaerobic bacteria, and has the advantages of being simple in process and low in cost. According to the preparation method, death of intestinal bacteria in the preparation process can be reduced, erosion of gastric acid and the like to the intestinal bacteria can be resisted, the survival rate of the bacteria and the colonization efficiency of the bacteria in host intestinal tracts can be remarkably improved, and the microbial transplantation treatment effect is further enhanced.

The invention discloses a preparation process and application of magnolol-loaded plant exosomes, and relates to the technical field of plant exosomes. Magnolol is extracted from a magnolia officinalis plant material through ultrasonic assistance, the plant exosomes are obtained from fresh ginger by using an ultracentrifugation method, and the plant exosomes are further modified through palmitic acid and polyethylene glycol, so that the magnolol-loaded plant exosomes are obtained. And finally, preparing the magnolol-loaded plant exosome by virtue of an incubation method. The magnolol can be protected from being damaged by gastric acid and digestive enzymes through membrane structure wrapping of the plant exosome, the stability of the magnolol in the digestive tract is improved, and it is further verified through mouse experiments that the magnolol-loaded plant exosome can be beneficial to regulation of intestinal flora.

The invention discloses a method for improving gastrointestinal tolerance of probiotics and a probiotic liquid core gel ball, the probiotic liquid core gel ball is prepared by adopting a calcium alginate cross-linked reverse spheroidizing method, and various indexes influencing the characteristics of the probiotic liquid core ball after re-culture are optimized, the process is simple in preparation, raw materials are natural and safe, the cost is low, and the method is suitable for industrial production. The tolerance and the survival rate of the probiotics in gastrointestinal digestion can be well improved, and the probiotic liquid core gel ball prepared by the method disclosed by the invention has good mechanical property, swelling rate and storage survival rate; by optimizing various parameters, such as re-culture time, core material liquid viscosity, polysaccharide molecular weight and a storage solution, which influence the characteristics of the probiotic liquid core ball after re-culture, the re-cultured liquid core ball has better mechanical properties, swelling rate and survival rate, and by combining with a gastric acid-cholate resistance reaction result, the survival rate of the liquid core ball is improved. The invention provides the preparation process of the re-culture solution core ball capable of effectively improving the gastrointestinal tolerance of the probiotics whether the core ball is broken or not.

The invention relates to a weight-losing and stomach-occupying device and a manufacturing method thereof.The weight-losing and stomach-occupying device is arranged in an inhalable mode and comprises a jelly substrate and hydrogel microspheres at least partially wrapped in the jelly substrate, and each hydrogel microsphere comprises a hydrogel microsphere body and a waterproof degradable film wrapping the hydrogel microsphere body; the material of the waterproof degradable film comprises chitosan and sodium alginate, the particle size of the hydrogel microsphere is 300-500 [mu] m, the waterproof degradable film can prevent the volume expansion of the hydrogel microsphere body in the jelly matrix, and the waterproof degradable film can be decomposed in a gastric acid environment to expose the hydrogel microsphere body wrapped in the waterproof degradable film, so that the size of the hydrogel microsphere body is reduced, and the hydrogel microsphere body is protected. The hydrogel microsphere body absorbs water to swell, stomach occupying is achieved, gastric emptying is prolonged, food intake is reduced through stomach occupying, the weight losing effect is achieved, and the weight losing and stomach occupying device is free of a rigid mechanical structure, has the amorphous characteristic, is smaller in compression and stimulation on the stomach, has flavor and can achieve the weight losing function when being taken, and the weight losing and stomach occupying device is suitable for being used for people. And a user can use the device more comfortably, so that the acceptability is higher, and the compliance of the user is improved.

The invention discloses a hydrogel plugging umbrella for gastric perforation and a preparation method thereof. The hydrogel plugging umbrella comprises a plugging part, and fixing parts are integrally formed at the two ends of the plugging part. The excellent plugging effect is achieved through the triple synergistic effect, the space mechanical interlocking effect brought by the double-umbrella-shaped design provides the immediate plugging and continuous self-expansion compaction effect, and physical and chemical adhesion of a tissue-gel interface ensures that under the corrosive gastric juice environment and the dynamic mechanical load, the plugging effect is good, and the plugging effect is good. A safe and lasting gastric perforation sealing effect can still be provided; the caffeic acid modified chitosan component has unique proton adsorption and biomolecule capture characteristics and can effectively block permeation of digestive enzymes such as gastric acid and pepsase, the protection effect not only maintains the activity of endogenous growth factors in a wound microenvironment, but also creates conditions beneficial to tissue regeneration, and the wound healing effect is improved. Therefore, healing and repairing of gastric perforation are remarkably promoted.

The invention discloses a feed additive for relieving ruminant rumen acidosis and a production process thereof, and the production process comprises the following steps: mixing starch-based Schiff base and deionized water in a reaction kettle to prepare a starch suspension, adding an oil suspension into the reaction kettle, heating until stirring, cooling, drying in vacuum, and crushing to obtain the feed additive for relieving ruminant rumen acidosis. And sieving to obtain the feed additive for relieving ruminant rumen acidosis. The prepared feed additive for relieving ruminant rumen acidosis can be stored under a dry condition, granulation and feed mixing are convenient, the feed additive contains starch and vegetable oil and is convenient for livestock to absorb, and rumen acid is rapidly neutralized by utilizing selenium-loaded magnesium oxide and sulfathiazole in the feed additive, so that the ruminant rumen acidosis is relieved, and the ruminant rumen acidosis is relieved. The absorption of the livestock on selenium element is improved through selenium salt in the selenium-loaded magnesium oxide, so that the immunity of the livestock is improved.

The invention belongs to the technical field of preparation of probiotics, and provides a bacterial strain with anti-allergic and immunity-improving effects and application of the bacterial strain. According to the method, a three-layer physical self-assembly structure is adopted, and polysaccharide-polyphenol layer-by-layer self-assembly coating treatment, lipid insertion layer treatment and calcium ion crosslinking protection coating treatment are sequentially carried out. And mannan oligosaccharide MOS and / or galactooligosaccharide GOS are / is mixed in the chitosan layer in a ratio of 0.05-0.15% w / v, and the surface sugar ligand density reaches 4-8 [mu] g per 10 CFU. The coating is constructed under the condition that the pH value is 5.4-5.8; the thickness of the lipid layer is 20-80 nm when the pH value is 5.6-6.2; the cross-linked layer is treated at the pH of 6.0-6.5, so that the gastric acid environment is stable for 2 hours, and the gastric acid is controllably released in intestinal juice for 2-4 hours. The prepared strain has the total thickness of 220-900 nm, the outermost layer coverage rate is larger than or equal to 85%, the gastric juice survival rate is remarkably improved, the strain can be prepared into an oral preparation to be used for preventing and relieving allergic diseases, the viable count of each dose is 1 * 10 <-1 > * 10 <-1 > CFU, and the process is mild and suitable for industrial production.

The invention provides a probiotic-loaded dual-network hydrogel as well as a preparation method and application thereof, and belongs to the technical field of probiotic embedding materials. The preparation method is simple to operate, the cross-linking reaction of the double-network hydrogel can be realized under mild conditions, and energy is saved. The prepared double-network hydrogel has high probiotic packaging efficiency, the packaging efficiency is 92.7% or above, and the double-network hydrogel has excellent gastric acid resistance and storage stability, so that the activity of the probiotics in gastrointestinal tracts is improved, and the double-network hydrogel is beneficial to human health. Besides, the preparation method provided by the invention is simple to operate, controllable, safe, low in cost and suitable for large-scale industrial production and processing, and has wide application prospects in the industries of food, health care products, daily chemical products, medicines and the like.

The invention belongs to the field of functional composite microbial preparations, and particularly discloses a microbial agent and GABA compounded composition and application thereof in promoting growth and development of children. The composition is prepared from a freeze-dried bacterial agent and a GABA (gamma-aminobutyric acid) compound, wherein the freeze-dried bacterial agent comprises lactobacillus johnsonii YH1136 and lactobacillus helveticus Helveticus; the GABA compound is prepared by loading GABA with the purity of greater than or equal to 98% on a nano cellulose carrier, and the loading rate is 20-35%. The composition realizes high survival rate of the microbial inoculum and targeted slow release of GABA through a freeze-drying process and enteric coating. Experiments show that the composition can significantly improve the serum GH / IGF-1 level, the bone mineral density and the body growth rate, and has a synergistic effect when combined with the vitamin D3. According to the invention, the problems of single strain function, low GABA utilization rate and gastric acid damage in the prior art are solved, and an efficient and safe solution is provided for children growth and development intervention.

The present application belongs to the technical field of biological medicine, and particularly relates to a chitosan-embedded probiotic gel microcapsule, a preparation method thereof and application of the microcapsule in preparation of an anti-Helicobacter pylori infection medicament. The superfine chitosan powder is used as a coating of the probiotic gel microcapsule, which is conducive to maintaining a high pH value in the microcapsule for a long time and providing a good living environment for the probiotic bacteria. Moreover, after the microcapsule enters the body, the peripheral chitosan powder first contacts the strong acid environment in the gastric juice, thereby providing a certain buffer barrier for the probiotic bacteria and the strong acid environment, so that the probiotic bacteria are prevented from being inactivated by the strong acid gastric acid. Meanwhile, the protonated chitosan shell plays a bridging role to make the microcapsule adsorbed on the gastric wall, thereby increasing the residence time of the microcapsule in the stomach, prolonging the time for the probiotic bacteria such as Bacillus natto to exert an ecological effect in the gastric juice, and finally achieving a good inhibitory effect on Helicobacter pylori.

The invention belongs to the technical field of materials, discloses a preparation method and application of novel stomach and intestinal tract passing sustained-release tannic acid, and particularly discloses a stomach and intestinal tract passing enteric coating material which comprises a surfactant, sugar alcohol, hydrogenated grease, polyacrylic resin and a thickening agent. The stomach-passing enteric coating material does not use expensive commercially available enteric coating materials, but adopts common surfactants, sugar alcohol substances and other substances, so that the grease and the water can be better fused, and the grease can be better coated outside in the coating process. The stomach-passing enteric coating material can ensure that tannic acid is not damaged by gastric acid, reduces the influence on animal digestive enzymes, and can be slowly released in intestinal tracts to be absorbed and utilized.

The invention relates to the technical field of empty capsules, in particular to a production process of enteric plant empty capsules. The preparation method comprises the following steps: firstly, taking hydroxypropyl methylcellulose as a main material, taking carrageenan, Tween 80 and sodium alginate as auxiliary materials, mixing the main material, the auxiliary materials and water, and carrying out glue dipping, forming, drying, demolding and cutting processes to obtain an empty capsule; the preparation method comprises the following steps: modifying chitosan by adopting sodium palmitate, so as to obtain chitosan-palmitate with hydrophobic property; and mixing the chitosan-palmitate with the hydroxypropyl methylcellulose acetate succinate to prepare a coating solution, and coating the hollow capsule to obtain a finished product. The prepared enteric plant empty capsule is high in yield, low in moisture absorption rate and long in disintegration time in gastric acid, it is ensured that effective components are released on the upper portion of the small intestine, and the absorption efficiency is improved.

The invention discloses a fibroin / zein-based dual-protein nanocapsule and a preparation method and application thereof.The dual-protein nanocapsule is prepared through a microfluidic-assisted nano-coprecipitation technology and comprises the following steps that silk fibroin is dissolved in a citric acid aqueous solution, and a mixed solution is obtained; the preparation method comprises the following steps: dissolving zein, curcumin and linseed oil in ethanol, rapidly mixing through a microchannel, and carrying out nano coprecipitation to obtain the dual protein nanocapsule. Through electrostatic interaction and amphiphilic regulation, a stable double protein shell structure is formed, curcumin is effectively protected from being damaged by gastric acid and digestive juice, targeted release of intestinal tracts is achieved, and the bioavailability of curcumin is remarkably improved. The obtained nanocapsule is uniform in particle size and good in dispersity, is suitable for a functional beverage system, and has a wide application prospect.