The invention relates to gel with anti-inflammation, anti-pruritus and sterilization effects, and belongs to the field of medicines. The gel is mainly applied to pediatric pruritic dermatosis, and can be used in different forms such as a therapeutic medicament and/or a sterilizer, a health care product, a sanitary product and the like for adjunctive therapy or for different purposes. The invention provides brand-new gel, wherein the gel is prepared by adding pharmaceutically acceptable minor ingredients into the following raw materials in parts by weight: 10 to 20 parts of lonicera japonica (lonicera confusa), 4 to 12 parts of belvedere fruit, 6 to 14 parts of astragalus mongholicus, 1 to 4 parts of lithospermum purpurocaeruleum, 8 to 16 parts of cortex dictamni, 1 to 4 parts of mint, 0.001 to 2 parts of borneol, 1 to 4 parts of cicada slough, 8 to 16 parts of talc, 1 to 4 parts of licorice and 0.1 to 2 parts of honey. By the gel, the effects of dispelling wind, clearing heat, cooling blood, resolving toxin, removing dampness, relieving itching, removing impurities and protecting skin can be effectively achieved; and the gel is particularly applied to the pediatric pruritic dermatosis such as pediatric papular urticaria, miliaria, dermatitis aestivale, diaper dermatitis and eczema.