286 results about "Disulfide bond" patented technology

The invention discloses an embolism part for peripheral arteriovenous vessels, the embolism part comprises an anchoring part and a blocking part fixedly connected with the anchoring part, the blocking part adopts polyurethane shape memory foam, the expansion rate of the polyurethane shape memory foam is 50-100 times, and a preparation method of the polyurethane shape memory foam comprises the following steps: step 1, preparing a polyurethane shape memory foam material; the preparation method comprises the following steps: preparing a polyurethane acrylate prepolymer from macromolecular polyol, diisocyanate, a chain extender containing disulfide bonds, other micromolecular chain extenders and an acrylate end-capping reagent; and 2, uniformly mixing the polyurethane acrylate prepolymer, a foaming agent, a foaming promoter and a photoinitiator to obtain a foaming solution, and sequentially carrying out light curing and foaming on the foaming solution to obtain the polyurethane shape memory foam. According to the embolism part, the polyurethane shape memory foam is adopted as the blocking part, the blocking part applies radial acting force to the wall of the blood vessel all the time based on the expansion trend of the blocking part, and the blocking part and the anchoring part jointly act and can be stably maintained in the blood vessel.

The invention provides a preparation method of a self-repairing resin-based composite material based on dynamic bonds. The self-repairing epoxy resin comprises one covalent dynamic bond of a Diels-Alder bond, a disulfide bond or a borate bond, and the preparation method of the self-repairing epoxy resin comprises the following steps: heating epoxy resin to a molten state, adding a curing agent component while stirring, and carrying out a prepolymerization reaction to obtain a prepolymer; the curing agent comprises a rigid diamine curing agent, a dynamic diamine monomer and a flexible chain segment regulator, and the dynamic diamine monomer contains a dynamic covalent bond; and carrying out curing molding on the prepolymer to obtain the self-repairing epoxy resin. And impregnating reinforced fibers or fabrics thereof with the prepared prepolymer, and heating and curing to obtain the self-repairing resin-based composite material. The invention provides a chemical molecule design, dynamic reversible chemical bonds are introduced into a resin matrix, and by constructing the dynamic bonds, the composite material has high performance of a traditional composite material and also has life-like self-healing ability.

The invention discloses a bionic lignin-based saline-alkali soil improvement material and a preparation method thereof, and belongs to the technical field of high polymer materials and soil improvement. According to the saline-alkali soil improving material, lignin or a derivative thereof serves as a framework, glutenin charge distribution and a dynamic disulfide bond sodium ion response function are simulated, and the sequence and the proportion of chain segments of sulfonic acid groups and quaternary ammonium salt groups are accurately regulated and controlled through step-by-step activation and alternate copolymerization in an aqueous solution polymerization reaction system; positive and negative charges form more uniform sequence distribution, so that the amphipathy of the lignin compound is realized; then, sulfydryl is introduced through click chemistry, linear regulation and control of material viscosity and water solubility are achieved through the chain transfer characteristic of multi-sulfydryl functional groups, and the requirements of different saline-alkali soil application scenes are met. The limitation that a traditional lignin product is single in function is broken through, efficient utilization of lignin is achieved, and the intelligent saline-alkali soil improvement material integrating high stability and pH and Na < + > multi-environment response is developed.

The invention discloses an OTX-015 (Ox-015) loaded cascaded responsive nano particle and a preparation method thereof. The nanoparticle has a three-layer core-shell structure, wherein the innermost layer is a cross-linked nanoparticle of chitosan and paclitaxel; the middle layer is a polydopamine layer loaded with a bromodomain inhibitor OTX-015; the outermost layer is a gelatin layer grafted with babali; wherein the cross-linked substance of the chitosan and the paclitaxel is a cross-linked substance containing a disulfide bond. The invention also provides a preparation method of the cascade responsive nano-particle and application of the cascade responsive nano-particle in preparation of an antitumor drug targeted delivery system. The nanoparticle provided by the invention improves the tumor microenvironment while activating in-vivo autoimmunity, and kills tumor cells by using photothermal therapy assisted chemotherapy drugs, so that the synergistic effect of chemotherapy / photothermal therapy / immunotherapy is realized, and a new idea is provided for clinical tumor treatment.

The invention discloses an RGD-click chemical crosslinking siRNA nano-carrier, a preparation method thereof and application of the nano-carrier in preparation of a medicine for treating secondary thyroidism, and belongs to the technical field of medicines.The nano-carrier is RGD-PEG-PLys (N), and the preparation method of the nano-carrier comprises the steps of synthesis of PLys (ss-DBCO), synthesis of RGD-PEG-PLys (N) and the like. According to the application, the nano-carrier is used for preparing siRNA composite nanoparticles; vascular endothelial targeting (RGD), dynamic stability (click crosslinking) and microenvironment responsiveness (disulfide bond) are organically combined for the first time to achieve mutual synergistic interaction, and the effect ceiling of an existing material is broken through; according to the siRNA composite nanoparticle, the silence effect of the PTH gene as long as 70 days can be achieved through single intravenous injection, the PTH inhibition rate is larger than 85%, the siRNA accumulation amount in parathyroid gland tissue is remarkably increased through RGD targeting (8.6 times that of a non-targeting group), the liver and kidney distribution amount is reduced by 60%, and the system toxicity is controllable.

The invention discloses a preparation method and application of a ceramic glaze layer protecting and repairing material, and belongs to the technical field of cultural relic protection. The preparation method comprises preparation of a core-shell self-repairing nanocapsule, and the preparation of the core-shell self-repairing nanocapsule comprises the following steps: reacting a calcium chloride solution with a sodium hydroxide solution, then adding sodium polyacrylate and nano ZnO, and carrying out dispersion, centrifugation, washing and other operations to prepare the nano Ca (OH) 2-ZnO composite material. The nano Ca (OH) 2-ZnO composite material of the core-shell self-repairing nanocapsule can be rapidly released through the 3.5 nm aperture of the mesoporous SiO2 shell, glaze layer cracks are physically filled and react with CO2 in air to generate CaCO3 crystals, crack plugging is achieved, meanwhile, dynamic disulfide bonds of a PU layer are broken and recombined under stress stimulation, a crack interface is repaired through chemical bonding, and the performance of the core-shell self-repairing nanocapsule is improved. The 24-hour crack repair rate is greater than or equal to 96%, and the limitation of'one-time repair 'of a traditional material is solved.

The invention relates to the technical field of anti-drag films, and particularly discloses an ultraviolet aging resistant anti-drag film and a preparation process thereof.A hindered amine light stabilizer HALs and a silane coupling agent KH-560 are introduced into substrate TPU resin, the strength, heat resistance and aging resistance of the material are enhanced, then an adhesive layer is formed on a substrate film, and the anti-drag film is prepared. A disulfide bond in the adhesive layer has a reversible fracture-self-repairing function, the fatigue resistance of the material is enhanced, the long-term service life of the material is prolonged, the surface layer is acrylic resin formed through copolymerization, the structure comprises a flexible alkyl chain and a siloxane chain segment, a microstructure is formed through hot rolling, the aerodynamic performance is optimized, and the purpose of reducing frictional resistance is achieved.

The invention relates to the technical field of environment-friendly high polymer materials, in particular to an environment-friendly furniture protective film and a preparation method thereof. The technical problems that a traditional furniture protection film is insufficient in toughness and short in service life are solved. According to the protective film disclosed by the invention, a polylactic acid, polyhydroxyalkanoate and dimer fatty acid ester flexibilizer blending material is taken as a matrix, a cyanoethylation lignin-cellulose nanocrystal compound reinforcing agent is added to form a dense nano network, and a dynamic cross-linking agent containing disulfide bonds and a functional auxiliary agent are introduced. According to the invention, a solvent-free ultraviolet light / damp and hot dual-curing system is adopted for coating and curing to prepare the coating. The furniture protection film is excellent in mechanical property, toughness is remarkably improved, and the furniture protection film has multiple functions such as high barrier property and the like and has the self-repairing capacity and the full-life-cycle environment-friendly characteristic.

The invention provides a lithium ion battery binder for inhibiting silicon expansion, a negative pole piece, a lithium ion battery and an electric device, and relates to the technical field of lithium ion batteries. The lithium ion battery binder capable of inhibiting silicon expansion comprises a first polymer and a second polymer, wherein the first polymer is a cross-linked polymer with dynamic reversible covalent bonds; wherein the dynamic reversible covalent bond comprises a disulfide bond or a borate bond; the binder network provided by the invention not only can effectively limit the excessive slippage of a polymer and provide higher mechanical strength, but also can generate reversible fracture and recombination at a stress concentration point in the charging and discharging process due to the dynamic reversibility of a disulfide bond or a borate bond, converts concentrated stress into fracture energy of a chemical bond and dissipates the fracture energy, so that the mechanical strength of the polymer is improved, and the service life of the polymer is prolonged. Therefore, permanent damage of the network is avoided, the pole piece structure is kept complete in long-term circulation, and stable electrochemical performance is achieved.

The invention provides a high-temperature-resistant and corrosion-resistant ammonia water nozzle coating and a preparation method thereof, and belongs to the field of coatings. The ammonia water nozzle coating is composed of a self-repairing metal ceramic bonding layer, an organic-inorganic hybrid corrosion-resistant layer and a functional surface layer which are sequentially arranged in a stacked mode. A coating of the self-repairing metal ceramic bonding layer is composed of the following components of 90-99 parts of NiCrAlY alloy and 1-8 parts of self-repairing microcapsules. A coating of the organic-inorganic hybrid corrosion-resistant layer is prepared from the following components: 40 to 60 parts of fluorinated polyurethane prepolymer, 20 to 40 parts of silicon-aluminum sol, 1 to 8 parts of disulfide bond modified epoxy resin and 10 to 20 parts of magnesium-aluminum hydrotalcite; the coating of the functionalized surface layer is prepared from the following components: 20 to 30 parts of stearic acid modified TiO2 particles, 60 to 80 parts of waterborne polyurethane and 2 to 7 parts of ionic liquid modified SiO2 nanoparticles. The corrosion resistance, the high temperature resistance and the self-repairing capacity of the ammonia water nozzle are improved at the same time.

The invention provides a bio-based super-hydrophobic coating magnesium alloy material with anti-icing and corrosion-resistant functions as well as a preparation method and application of the bio-based super-hydrophobic coating magnesium alloy material. According to the material, a polylipoic acid-metal ion-hydrophobic carbon black coating is constructed on the surface of the pretreated magnesium alloy, so that the key problems that the corrosion rate of the magnesium alloy is high and the surface of the magnesium alloy is easy to freeze in practical application are solved. The coating is firmly combined with a matrix through multiple hydrogen bond effects, and the coating is endowed with rapid self-repairing capability by virtue of synergistic dynamic effects of disulfide bonds, hydrogen bonds and metal coordinate bonds. And meanwhile, the doped hydrophobic carbon black particles obviously improve the surface super-hydrophobic performance. The self-repairing characteristic is combined with the super-hydrophobic structure, so that corrosion medium infiltration is effectively blocked, and the corrosion process of the magnesium alloy is greatly delayed. In addition, the coating has photo-thermal and electrothermal effects, active anti-icing and efficient deicing can be achieved, and the application potential of the magnesium alloy in a severe environment is remarkably expanded.

The invention relates to a keratin bonding microcapsule as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The microcapsule comprises diethylhexyl maleate, keratin amino acids and hydrolyzed keratin which serve as main active components of a capsule core to form a keratin bonding agent and serve as a keratin reconstruction compound; the capsule wall is of a double-layer structure; the inner layer is a three-dimensional network formed by self-assembly of hydrolyzed keratin, keratin amino acids and a hydrophilic polymer interface; and the outer layer is a compact polymer film formed by copolymerization of an acrylate monomer and a cross-linking agent. The microcapsule disclosed by the invention can be applied to a perm agent, a hair dye or a hair care product, and is used for targeted repair of broken disulfide bonds in the perm and dyeing process, reversal of keratin damage, repair of damaged hair quality, improvement of hair breaking strength and reduction of broken hair.

The invention discloses a preparation method and application of a dual-targeting carrier-free delivery system for enhancing anti-tumor immunity of NKT cells, Lys-alpha-GalCer is used as a raw material, and two molecules of LGC are connected through a disulfide bond to synthesize an amphiphilic LGC-SS-LGC micromolecule prodrug; the LGC-SS-LGC micromolecule prodrug is prepared into vesicles internally loaded with an NKT cell antigen presenting molecule CD1d and externally modified with polysarcosine through electrostatic adsorption through a film dispersion-probe ultrasonic method, finally a CD1d / LGC-SS-LGC / PSar dual-targeting carrier-free delivery system is formed, and the dual-targeting carrier-free delivery system can be used for liver cancer treatment after intravenous administration. In addition, the compound can be used for preparing a preparation for enhancing NKT cell Th1 type immune response. The dual-targeting carrier-free delivery system prepared by the invention can directly or indirectly enhance the anti-tumor immune effect of the NKT cells, and has a dual-synergistic effect.

The invention discloses a self-repairing polyurethane-boron nitride composite heat conduction material and a preparation method thereof, an electronic device heat dissipation material and a flexible sensor, and relates to the technical field of polymer composite materials. The preparation method of the self-repairing polyurethane-boron nitride composite heat conduction material comprises the following steps: carrying out a first polycondensation reaction on polydihydric alcohol and a diisocyanate monomer to obtain an intermediate, and carrying out a second polycondensation reaction on the intermediate and an aromatic amino compound containing disulfide bonds to obtain a polyurethane matrix; and mixing the polyurethane matrix and the zinc ion-tannic acid co-modified boron nitride to obtain a mixture, casting the mixture into a mold, and curing to obtain the self-repairing polyurethane-boron nitride composite heat-conducting material. The heat conductivity coefficient of the self-repairing polyurethane-boron nitride composite heat conduction material reaches 4.8 W.m <-1 >. K <-1 >, the material can be self-repaired at normal temperature after being broken, the repairing efficiency reaches up to 96%, and the problem that self-healing performance and heat conductivity of an existing polyurethane material are difficult to consider at the same time can be effectively solved.

The invention relates to the technical field of high polymer materials, in particular to a low-viscosity self-curing polyurethane acrylate composition and a preparation method thereof.The low-viscosity self-curing polyurethane acrylate composition is prepared from, by mass, (a) 50-80 parts of polyurethane acrylate prepolymer; (b) 1-10 parts of functional particles; (c) 10-30 parts of a reactive diluent; (d) 0.1-2 parts of a visible light initiator; (e) 0.1-2 parts of a leveling agent; and (f) 0.1-1 part of a deoxidizing auxiliary agent. According to the invention, light response is expanded to a visible light wave band, natural light can trigger free radical polymerization and disulfide bond oxidative cleavage through component and structural design to realize controllable release of water, the system viscosity of an acrylate group is further reduced to 1500mPa. S or below, and the adhesive property and weather resistance are better after curing.

The invention discloses a preparation method of a double-response self-repairing super-hydrophobic coating on the surface of an aluminum alloy. The preparation method is specifically implemented according to the following steps: step 1, preparing sea urchin-shaped photo-thermal particles Fe3O4-at-TiO2; step 2, preparing self-repairing porous boron nitride; 3, preparing thermal response particles by an emulsion method; step 4, carrying out photocuring and dynamic disulfide bond crosslinking modification; and 5, preparing the double-response self-repairing super-hydrophobic coating. The invention also discloses the coating prepared by the method, the light absorption area is increased by preparing the sea urchin-shaped Fe3O4-coated TiO2, and after the two materials form a heterojunction, absorption spectrums complement each other, so that the energy of sunlight can be more efficiently utilized, and the photothermal conversion efficiency is improved. Porous boron nitride (PBN) increases the specific surface area, loads more perfluoropolyether and forms a continuous heat conduction channel through a porous framework to improve the heat conductivity, it is guaranteed that heat can be transmitted to the thermal response shell to the maximum extent, and the thermal response efficiency is improved.

The invention provides a dual-network hyaluronic acid-silk fibroin gel sponge and a preparation method thereof, and belongs to the technical field of gel sponge materials. The preparation method comprises the following steps: mixing sulfhydrylation modified hyaluronic acid and a silk fibroin solution, and sequentially performing freezing and soft freezing treatment to form the hyaluronic acid-silk fibroin gel sponge with a good shape. In the freezing induction process, hyaluronic acid generates chemical crosslinking through disulfide bonds, silk fibroin forms physical crosslinking through freezing concentration, and finally the stable gel-sponge coexistence body with the double-network structure is formed. The gel sponge has double advantages of gel and sponge. Meanwhile, due to freeze concentration treatment, the gel sponge has a macroporous structure, which is beneficial to potentially promoting adhesion, proliferation and migration of cells; the prepared gel sponge does not introduce additional chemical reagents, the biological safety of the gel sponge is guaranteed, and the gel sponge is suitable for the fields of cartilage / skin repair, tissue filling, wound dressing and the like.

A self-healing polyurethane-based coating composition, a polyurethane-based coating film including the same, and methods of manufacturing the coating composition and the coating film, in which design of an oligomer containing a disulfide functional group is capable of achieving self-healing performance at room temperature and ensuring appropriate fluidity, whereby a coating film can be manufactured by spraying. The composition further includes a polyisocyanate hardener, and the oligomer is formed by polymerizing a carbonate-type diol, an alicyclic isocyanate, and an aromatic disulfide-type diol. This specific molecular design provides high self-healing efficiency, enhanced optical transparency, and excellent mechanical stability. The coating film achieves a self-healing efficiency of 80% or more, a transmission rate of 85% or higher, and a sagging rate of 5% or less. The manufacturing process controls the molar ratios of hydroxyl (—OH) to isocyanate (—NCO) groups, optimizing cross-linking and ensuring durability in the final coating.

The invention relates to the technical field of biomedical material modification, in particular to a sulfhydrylation biocompatible polymer derivative, a preparation method thereof, extracellular matrix imitating injectable in-situ cross-linked hydrogel and application thereof. According to the invention, a pre-acylation strategy is firstly carried out on the biocompatible polymer containing both amino and carboxyl, so that a three-dimensional cross-linked byproduct formed by coupling of self amido bonds is avoided, meanwhile, the number of side chain carboxyl for sulfhydrylation modification is increased, and the accurate and adjustable pre-acylation rate can optimize the physical and chemical properties of the derivative; meanwhile, a disulfide bond is used as a protective precursor, active sulfydryl is introduced through amido bond coupling, self-oxidation of the active sulfydryl in the reaction process is avoided, sulfydryl activity is guaranteed, hydrazine-containing reagents are avoided, safety is further improved, virus residues and immunological rejection risks are avoided, universality is high, and the application prospect is wide; and in combination with a high-concentration preparation method, the method has the advantage of large-scale production, and further widens the industrial application potential.

The invention relates to the technical field of high polymer materials, in particular to a high-adhesion polyimide resin material and a preparation method thereof, and the high-adhesion polyimide resin material is prepared from a polyimide precursor and a surface modified inorganic filler; wherein a dynamic disulfide bond network constructed by a thioctic acid modified diamine monomer enables the material to achieve a scratch repair rate of 88% or above within 12 h after being heated at 60 DEG C, the service life is remarkably prolonged, and the material is endowed with an ultraviolet absorption rate of 90% or above through the synergistic effect of triazine ring dianhydride and thioctic acid; according to the present invention, the silane coupling agent modified filler enables the damp-heat resistance time to break through 2800h, and is nearly doubled compared with the traditional material, the heat conductivity coefficient of 0.60-0.65 W / mK is achieved through the compound filler system and the dynamic cross-linking structure, the high adhesion of 7.1 N / cm is maintained, the high-end electronic packaging requirement is met, and the wide application prospect is provided.

The invention provides vitamin B12 modified microspheres capable of efficiently loading His tag recombinant protein as well as a preparation method and application of the vitamin B12 modified microspheres, and belongs to the technical field of biological medicines. The preparation method of the vitamin B12 modified microsphere for efficiently loading the His tag recombinant protein comprises the following steps: (1) carrying out esterification reaction on unsaturated fatty acid containing sulfydryl, disulfide bond or olefinic bond, saturated fatty acid and vitamin B12 to prepare an amphiphilic vitamin B12-lipid conjugate; and (2) taking the amphiphilic vitamin B12-lipid conjugate, PLGA (poly (lactic-co-glycolic acid)), a multi-sulfydryl cross-linking agent and a photoinitiator as raw materials, and preparing the raw materials into microspheres by adopting a microfluidic method, so as to obtain the vitamin B12 modified microspheres capable of efficiently loading various His tag recombinant proteins. The microsphere provided by the invention overcomes the problems of protein load stability and burst release of traditional microspheres, and various different His tag recombinant growth factors can be flexibly selected according to the requirements on different growth factors in treatment of complex bone defects caused by different pathogenesis.

The invention discloses a sorafenib-paclitaxel combined prodrug as well as a preparation method and application thereof, and relates to the field of chemical pharmacy, a prodrug strategy is utilized, sorafenib and paclitaxel are covalently linked through a disulfide bond, and an S-PTX drug is successfully prepared. The drug can be self-assembled to form stable nanoparticles in an aqueous solution system containing 1% of absolute ethyl alcohol and 1% of polyoxyethylated castor oil by means of hydrophobic interaction, Van der Waals force and the special chemical properties of disulfide bonds. According to the invention, the drug delivery is carried out without any additional carrier, so that the problem of carrier toxicity when the carrier is introduced into the traditional nano delivery system is avoided, the safety of the drug in in-vivo application is greatly improved, and a solid and reliable foundation is provided for subsequent clinical treatment. The sorafenib-paclitaxel combined prodrug S-PTX prepared by the invention effectively solves the problem of drug resistance caused by medication of a single drug.

The invention discloses a polyimide adhesive based on cooperation of double dynamic bonds and a preparation method thereof, hydrogen bonds, dynamic disulfide bonds and flexible molecular chain segments are introduced into polyimide through copolymerization of fluorinated dianhydride and two different diamines, and the obtained high-molecular-weight dynamic polyimide adhesive is adjustable in rigidity and flexibility, and has the advantages of high-molecular-weight dynamic polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide, high-molecular-weight polyimide and the like. Meanwhile, the glass transition temperature is high (the maximum Tg is 265.4 DEG C), and the self-repairing capacity and the low-boiling-point organic solvent rapid dissolving and recycling capacity are achieved. In addition, the adhesive has excellent tensile shear strength (as high as 12.54 MPa). Preferably, graphene (GNP) is added into the double-dynamic polyimide matrix for ultrasonic mixing, and the polyimide-based heat-conducting adhesive is prepared through thermal imidization. When the content of GNP is 7.5 wt%, the in-plane heat conductivity coefficient of the material is 3.32 W / (mK), and the tensile shear strength of the heat-conducting adhesive can reach 8.49 MPa, so that the heat-conducting adhesive can be comparable with a high-performance commercial heat-conducting adhesive, and can be used as a reusable adhesive between heat management material interfaces.

The invention discloses a temperature-sensitive self-repairing expandable epoxy resin material and a preparation method thereof. The temperature-sensitive self-repairing expandable epoxy resin material is prepared from the following components: 1) epoxy resin; 2) a curing agent containing a dynamic covalent bond, wherein the dynamic covalent bond is selected from a disulfide bond and an ester bond; 3) a catalyst; the porous material is used for regulating and controlling the expansion performance; the epoxy resin and the curing agent are subjected to cross-linking reaction under the action of the catalyst to form a three-dimensional network structure, so that the epoxy resin material has self-repairing performance, and meanwhile, the epoxy resin material has expansion performance through a solid-state composite foaming method and a hot compression mode. According to the invention, the dynamic covalent bond is added, so that the cured epoxy resin material can be self-repaired at 40-100 DEG C, the repair efficiency is 90% or more, meanwhile, a micromolecule ethylene glycol solution is added at high temperature, the epoxy resin material can be degraded and recycled, the utilization rate of the material is greatly improved, and after the porous material is added, the expansion rate can reach 0-80% through a solid composite foaming method.

The invention belongs to the field of lithium ion batteries, and particularly relates to a semi-solid lithium battery diaphragm and a preparation method thereof.The semi-solid lithium battery diaphragm comprises a base membrane and gradient functional coatings coated on the two sides of the base membrane, the base membrane is a polyimide membrane, and each gradient functional coating comprises a bonding layer on the bottom layer, a regulating layer on the surface layer and a filling layer located between the bonding layer and the regulating layer; the bonding layer comprises a component A, and the component A comprises a polymer matrix, a disulfide bond-containing cross-linking agent, a coupling agent and a first solvent; the polymer matrix comprises polyimide and polyurethane; the filling layer comprises a component B and a component A, and the component B comprises core-shell particles and a dispersing agent, wherein the core-shell particles are formed by coating Li1. 3Al0. 3Ti1. 7 (PO4) 3 particles with ZrO2; the regulation and control layer comprises perfluorinated sulfonic acid resin, a plasticizer, an interface stabilizer, a second solvent and deionized water. Through the synergistic effect of all the layers in the gradient functional coating, the self-repairing performance of a damaged interface of the diaphragm can be achieved, and the strength of the diaphragm is improved.

The invention discloses a degradable and recoverable epoxy Vitrimer as well as a preparation method and application thereof, and belongs to the technical field of functional materials and preparation thereof. The problems that existing epoxy resin is not melted and unrecyclable, and the mechanical property and breakdown field strength are seriously reduced after recycling are solved. According to the invention, 2-AFD is used as a curing agent of DGEBA, and a dynamic disulfide bond is introduced in the curing process of DGEBA, so that the epoxy resin is endowed with degradable and recoverable properties. DGEBA is used as a raw material, and vanillin-based epoxy resin (VOEP) with a reversible dynamic covalent bond (-C = N-) is further used for replacing a part of DGEBA, so that the epoxy resin realizes high-performance retention rate hot-pressing recovery, and meanwhile, the epoxy resin can be degraded in a mercaptan solution and can also be degraded in an n-hexylamine solution.

The invention discloses a high-toughness self-repairing plastic runway adhesive based on double-sulfur dynamic crosslinking, which is characterized by comprising the following components in percentage by weight: 57-70% of polyhydric alcohol composition, 5-10% of dithiol, 5-10% of dithiol, 5-10% of dithiol, 5-10% of dithiol, 5-10% 25 to 35% of diisocyanate; 3-8% of a chain extender containing dynamic disulfide bonds; 1-3% of in-situ modified nano cerium dioxide; 0.05 to 0.13 percent of a composite catalyst; 0.3 to 0.7% of a hydrolysis resistant agent; 2.0 to 6.0 percent of flame retardant; 0.2%-0.5% of an antioxidant; wherein the ratio of the total mole number of isocyanate groups in the diisocyanate to the total mole number of hydroxyl groups in the polyol composition and the chain extender containing the dynamic disulfide bonds, namely the mole ratio of NCO to OH is (2.2-3.5): 1. The invention also discloses a preparation method of the composition. According to the invention, by introducing a dynamic disulfide bond (HEDS) and a specific composite catalyst, after a cured adhesive layer generates microcracks, a molecular network of the cured adhesive layer can realize self-repairing through reversible exchange of the disulfide bond, the mechanical property is remarkably recovered, and the service life of a runway is greatly prolonged.

The invention belongs to the technical field of coatings, and particularly relates to textured high-toughness polyester resin as well as a preparation method and application thereof. The textured high-toughness polyester resin is prepared from the following raw materials: polyol, polyacid, carboxyl silicone oil, a dynamic cross-linking agent, an acidolysis agent and carboxyl-terminated nitrile rubber. The dynamic cross-linking agent contains at least two carboxyl groups and one disulfide bond. Through the synergistic effect of the dynamic cross-linking agent, the carboxyl silicone oil and the carboxyl-terminated nitrile rubber, the problem that a traditional texture type powder coating is insufficient in toughness is solved, and the impact resistance, the flexibility, the low-temperature mechanical property and the self-repairing capacity of a coating are remarkably improved while clear textures are kept.

The invention discloses a method for repairing cracks of cultural relics, a repairing coating and a method, and relates to the technical field of cultural relic repairing. The preparation method of the repair coating comprises the following steps: step 1, mixing isocyanate and a hydroxyl compound in an inert gas atmosphere, and reacting the isocyanate and the hydroxyl compound under a first reaction condition to generate a first intermediate product; step 2, adding a sulfhydryl compound into the first intermediate product to obtain a mixture, dropwise adding an oxidizing agent into the mixture under a second reaction condition, and reacting the mixture in the dropwise adding process to generate a second intermediate product; and 3, carrying out emulsification treatment and pH value adjustment on the second intermediate product to obtain a waterborne polyurethane dispersion liquid, and sequentially carrying out filtration and solid content adjustment on the waterborne polyurethane dispersion liquid to obtain the repair coating. The repairing coating disclosed by the invention has efficient self-repairing capability, and the repairing coating contains disulfide bonds, so that the repairing coating realizes fracture and recombination under mild conditions.

The application discloses a drug-loaded micelle capable of effectively crossing the blood-brain barrier, which is an amphiphilic conjugate composed of a reduction-sensitive paclitaxel prodrug and a nucleic acid complex, wherein the reduction-sensitive paclitaxel prodrug is used as a hydrophobic part, and the nucleic acid complex is used as a hydrophilic part, and the drug-loaded micelle is self-assembled in an aqueous environment; the reduction-sensitive paclitaxel prodrug is formed by the reaction of paclitaxel and a disulfide bond-containing linker; and the nucleic acid complex is formed by connecting an antisense oligonucleotide and an interfering RNA through a DNA bridge. The drug-loaded micelle exhibits superior blood-brain barrier penetration, effectively realizes enrichment in brain tumors, solves the problem of low blood-brain barrier penetration efficiency of existing nano-carriers, and provides an effective basis for brain drug delivery and brain diseases such as brain tumor imaging and treatment.