5results about "Amide group formation/introduction" patented technology

The present disclosure relates to methods for dealkenylative amination. The present disclosure additionally relates to methods for dealkenylative azidation.

The application discloses a method for preparing primary amide by using bromine difluoroacetamide to mediate carboxylic acid, and relates to the technical field of organic synthesis. The method effectively solves the problem of poor direct condensation reactivity in the traditional route, and does not need to use expensive condensing agents or metal catalysts, thereby avoiding the harsh requirement of the acyl chloride method on anhydrous operation. The method exhibits excellent reaction efficiency and wide substrate universality under an air atmosphere, and has good compatibility with acid-sensitive groups. Notably, the reaction condition is mild, special equipment and anhydrous and anaerobic control are not needed, and post-treatment is simple, so that the production cost and waste discharge are significantly reduced. The above advantages jointly provide a practical and sustainable green synthesis route for the large-scale preparation of primary amide compounds.

The application provides a bio-based carbonylation reagent and a preparation method and application thereof. The bio-based carbonylation reagent provided by the application comprises methyl esterified cellulose. The carbonylation reagent provided by the application is convenient to prepare, low in price, stable in property, mild in carbon monoxide releasing condition, and capable of being applied to various carbonylation reactions.