691results about "Urea derivatives preparation" patented technology

The invention provides a VEGFR2-HDAC6 dual inhibitor containing chalcone fragments as well as a preparation method and application of the VEGFR2-HDAC6 dual inhibitor, and relates to the technical field of medicinal chemistry. The invention discloses a VEGFR2-HDAC6 dual inhibitor containing chalcone fragments. The structural formula of the VEGFR2-HDAC6 dual inhibitor is shown as a formula A, according to the invention, the VEGFR2-HDAC6 dual inhibitor containing the chalcone fragment and having a novel structure is designed and synthesized by utilizing a splicing principle, the anti-proliferative activity test is carried out on cervical cancer cells Siha and chronic granulocytic leukemia cells K562, and the result shows that the VEGFR2-HDAC6 dual inhibitor containing the chalcone fragment provided by the invention has relatively good inhibitory activity on the Siha cells and the K562 cells.

The present invention relates to a novel process for the preparation of substituted phenylurea derivatives, in particular 3-(3,4-dichlorophenyl)-1,1-dimethylurea.

The invention discloses an efficient anti-crystallization urea solution for vehicles and a preparation method thereof, and belongs to the technical field of preparation of urea solutions for vehicles, the preparation method comprises the following steps: preparing an inclusion compound, hydrolyzing and crystallizing, dissolving, filtering, finely filtering and ultra-filtering; the hydrolytic crystallization method comprises the following steps: mixing industrial urea and three-stage water, stirring at 70-75 DEG C for 30-40 minutes, carrying out first gradient cooling and second gradient cooling, adding an inclusion compound, carrying out third gradient cooling and fourth gradient cooling, preserving heat, centrifuging, and taking a precipitate. During preparation, the industrial urea is used as a raw material, the prepared efficient anti-crystallization urea solution for the vehicle is low in impurity content, free of precipitates and high in urea yield, the urea yield is slightly influenced by the impurity content in the industrial urea, and when precipitates in the urea solution are removed through an ultrafiltration method, the membrane flux is slightly influenced by the precipitate content in the urea solution; the problem of membrane pollution can also be avoided.

Ammonia, methanol, Fischer Tropsch products, and derivatives thereof are made by using hydrogen and oxygen supplied from an electrolyzer that is at least partially powered by renewable power, resulting in green process and systems that produce green products disclosed herein. A process using biomass and renewable energy includes producing an unshifted syngas from biomass and oxygen in a gasification unit, introducing water into an electrolyzer to produce an oxygen product and a hydrogen product, and introducing the oxygen product to the gasification unit. The electrolyzer is powered by renewable energy, and the oxygen product supplies at least a portion of the oxygen to the gasification unit.

The present invention provides an improved low-energy-consumption urea production process by CO2 stripping method. A part of the urea synthesis liquid is sent into the high-pressure CO2 stripper in the high-pressure decomposition and recovery system for stripping and decomposition, and then is sent into the medium-pressure pre-separator after being decompressed by the first hydraulic turbine or / and pressure reducing valve; another part of the urea synthesis liquid is directly sent into the medium-pressure pre-separator after being decompressed by the second hydraulic turbine or / and pressure reducing valve, and the urea solution at the outlet of the medium-pressure pre-separator is sent into the shell side of the urea decomposition heater; a part of the gas phase of the high-pressure CO2 stripper is sent into the high-pressure carbamate condenser, and another part is sent into the tube side of the medium-pressure decomposition heater, and the liquid phase at the outlet of the high-pressure ammonia ejector is also sent into the tube side of the medium-pressure decomposition heater. The carbamate liquid is sent into the high-pressure carbamate condenser after coming out of the tube side of the medium-pressure decomposition heater; the urea solution coming out of the shell side of the urea decomposition heater is sent into the medium-pressure urea rectifying column and then into the low-pressure rectifying column, and then into the slightly positive pressure flash tank. The process of the present invention is simple, low in cost and low in steam consumption.

The invention provides a compound containing a ureido structure, a negative photosensitive resin composition and a preparation method and application of the negative photosensitive resin composition. The compound containing the ureido structure can be used as a photo-crosslinking agent; when being added into the photosensitive resin composition, the compound can improve the resolution ratio and mechanical property of a photosensitive resin composition cured film and the adhesiveness with a base material, and can effectively inhibit the oxidation discoloration of a copper base material.

The invention belongs to the technical field of drug synthesis, and particularly relates to an adamantane derivative as well as a synthesis method and application thereof. The adamantane derivative comprises an intermediate structural formula I, an intermediate structural formula II and an intermediate structural formula III, and the structural general formula is as follows: Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the adamantane derivative provided by the invention, an adamantane structure is combined with part of groups of OAB-14, and a parent nucleus structure is changed, so that the drug activity is improved. The invention also provides a synthesis method of the compound, the obtained compound is screened through cell viability research, and the compound has a potential synergistic effect in the aspects of preventing influenza and treating Alzheimer's disease.

The invention relates to a kettle residue recovery process of methyl carbamate, and belongs to the technical field of chemical engineering, the kettle residue recovery process of methyl carbamate comprises the following steps: adding the kettle residue of methyl carbamate into water, stirring for dissolving, adding chloroform, extracting, standing for layering, taking an oil phase dissolved with methyl carbamate at the lower layer, cooling to room temperature, filtering, washing, and drying to obtain the methyl carbamate. Drying to constant weight to obtain recycled methyl carbamate; and adjusting the pH value of an upper water phase composed of impurities such as urea, biuret and triuret to 7.5-8 by using a pH regulator, introducing into a sealed reaction tank filled with a modified mesoporous molecular sieve, adsorbing at normal temperature and normal pressure, filtering, and treating the filtrate at 60-80 DEG C to obtain the recycled and treated urea. The whole preparation process is simple and controllable, and the methyl carbamate and the urea in the kettle residues of the methyl carbamate are recycled.

A hydrogen production system for producing a hydrogen gas product includes a geologic hydrogen source configured to provide a feedstock comprising hydrogen, nitrogen, and helium and purification equipment comprising two or more of: a pressure swing adsorption (PSA) device; a guard bed; a separation membrane; a reactive membrane; or a cryogenic separation device. The purification equipment is configured to receive the feedstock from the geologic hydrogen source and produce a hydrogen gas product, and production of the hydrogen gas product exhibits a carbon intensity score less than 3.0 kg CO2 eq / kg H2.

This invention discloses a method for improving the yield of urea phosphate in the preparation of wet-process phosphoric acid. The method involves mixing a crystallizer with wet-process phosphoric acid and urea, reacting the mixture, and then cooling, crystallizing, filtering, and drying to obtain urea phosphate. Alternatively, wet-process phosphoric acid is mixed with urea and reacted. After the reaction, a crystallizer or a urea phosphate mother liquor containing the crystallizer is added, followed by cooling, crystallizing, filtering, and drying to obtain urea phosphate. The crystallizer is one or a mixture of two or more of ethylene glycol methyl ether, ethylenediaminetetraacetic acid, and citric acid in any proportion. The urea phosphate produced by this method is in crystalline form, meeting the industrial urea phosphate standard (GB / T27805-2011), satisfying market demand, and featuring a low-cost crystallizer with flexible addition methods, making it very convenient for practical production.

The present invention relates to a process for the production of melamine and the production plant including an off-gas condensation step carried out at a pressure of 70 to 220 bar by feeding gaseous and liquid streams at the same pressure, converting the liquid stream from the off-gas condensation step to a first stream, followed in succession by a high pressure decomposition step, a medium pressure decomposition step, a low pressure decomposition step, and urea concentration step.

The invention provides a method for preparing carbon isotope labeled urea by taking divalent carbonate as a raw material, and belongs to the technical field of helicobacter pylori detection. The method comprises the following steps: S1, mixing acid with divalent carbonate powder, and collecting generated carbon dioxide; s2, drying the carbon dioxide, and introducing a nitrogen source solution until the carbon dioxide is saturated to obtain a reaction solution; s3, sequentially carrying out heating reflux, cooling, filtering, solvent removal and vacuum concentration on the reaction liquid to obtain carbon-labeled C (NTMS) 2; s4, dissolving the carbon-labeled C (NTMS) 2 in 1, 4-dioxane, then adding a hydrogen fluoride aqueous solution and oxalic acid, carrying out a reflux reaction, collecting a solid, and drying to obtain carbon isotope labeled urea; the divalent carbonate in the S1 is marked by carbon 13 or carbon 14. The high-purity carbon isotope labeled urea is prepared by adopting the carbon labeled divalent carbonate as the raw material, the preparation condition is mild, the synthesis process is convenient, green and environment-friendly, and the method is suitable for industrial production.

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of urea [14C]. The synthesis method of the urea [14C] comprises the following steps: (1) reacting carbonate [14C] with ammonia gas to obtain cyanamide salt [14C]; (2) hydrolyzing the cyanamide salt [14C] obtained in the step (1) with concentrated sulfuric acid at the hydrolysis temperature of 35-45 DEG C; and (3) adjusting the pH value of the hydrolysate obtained in the step (2) with ammonia water, concentrating and purifying to obtain urea [14C]. The synthesis method provided by the invention has the advantages of mild conditions, efficient reaction, high product yield (up to 95% or above), high purity (the chemical purity is greater than or equal to 99%) and the like, and is suitable for large-scale preparation of key raw materials of helicobacter pylori diagnostic reagents.

The objective of the present invention is to provide a method for producing a halogenated carbonyl safely and efficiently. The method for producing a halogenated carbonyl according to the present invention is characterized in comprising the step of applying ultrasound to a composition containing a C1-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen to decompose the C1-4 halogenated hydrocarbon.

The invention belongs to a urea synthesis system using liquid carbon dioxide and a urea synthesis method. Comprising a urea synthesis tower, the urea synthesis tower is respectively connected with a liquid ammonia pipeline and a carbon dioxide gas pipeline, the carbon dioxide gas pipeline is connected with an outlet of a liquid-phase carbon dioxide delivery pump through a liquid-phase carbon dioxide vaporization unit, and an inlet of the liquid-phase carbon dioxide delivery pump is connected with a liquid-phase carbon dioxide delivery pipeline; liquid carbon dioxide is directly used as a raw material, a liquid-phase carbon dioxide delivery pump is used for pressurization, and gasification is carried out after pressurization, so that the liquid carbon dioxide meets the requirements of a urea synthesis tower, and the characteristics of saving urea synthesis energy consumption, reducing the use amount of circulating water and reducing the occupied area of equipment are achieved.

The invention provides a low-energy-consumption urea synthesis system and method, and the system comprises a high-pressure synthesis unit which comprises a synthesis tower, a condensation part and a stripping tower; cO2 gas, liquid ammonia and methylamine liquid from the condensation part are introduced into the synthesis tower for a synthesis reaction; the synthesis tower is connected with the stripping tower to introduce the liquid generated by the synthesis reaction into the stripping tower; the synthesis tower is connected with the condensation part to introduce NH3 and CO2 gas generated by synthesis reaction into the condensation part; the stripping tower is connected with the condensing part to introduce NH3 and CO2 into the condensing part; a medium-pressure decomposition recovery unit; a low-pressure decomposition recovery unit; and a urea solution processing unit. By simplifying the high-pressure synthesis unit for urea synthesis, arranging the efficient medium-pressure decomposition and recovery unit, designing and transforming the urea production energy-saving system and optimizing the production process, the energy consumption of urea production is greatly reduced, and the urea synthesis process meets the production requirements of energy conservation and low energy consumption.

The invention relates to a method and device for preparing urea through photocatalysis and piezoelectric catalysis of CO2, and the method comprises the following steps: adding a catalyst into water, introducing CO2 and N2 into the water, and reacting under the action of illumination and ultrasonic waves to obtain a urea solution; the light intensity of illumination ranges from 200 mW / cm < 2 > to 300 mW / cm < 2 >; the catalyst is selected from one or more of CdS (cadmium sulfide), ZnO (zinc oxide), WO3 (tungsten trioxide), BiOCl (bismuth oxychloride) and Bi4NbO8Cl (bismuth oxychloride). The technical problem to be solved is to provide a method for preparing urea by photocatalysis and piezoelectric catalysis of CO2, according to the method, under the action of illumination, ultrasonic waves and a catalyst, photocatalysis and piezoelectric catalysis of CO2 are combined, urea synthesis can be carried out at normal temperature and normal pressure, the yield of urea can be improved, and a new direction is developed for green and efficient synthesis of urea. Furthermore, the device can integrate air carbon capture coupling photocatalysis and piezoelectric catalysis CO2 preparation of urea into a set of continuous device, a large amount of energy input is not needed, multi-step separation can be avoided, the device is simple, and the cost can be greatly reduced.

A process includes feeding atmospheric air to an air separation unit to produce a flow of nitrogen and a flow of oxygen; combining the oxygen with a hydrocarbon flow and water in an auto-thermal reformer to produce a retentate stream to a membrane water gas shift reactor (M-WGSR); generating, from the retentate stream to the M-WGSR, a permeate stream from the M-WGSR that includes a first flow of carbon dioxide and a first combined flow of hydrogen and nitrogen; feeding a retentate stream to a membrane steam methane reformer (M-SMR) to produce a permeate stream from the M-SMR that includes a second flow of carbon dioxide and a second combined flow of hydrogen and nitrogen; feeding the first and second combined flows to an ammonia synthesis unit to produce ammonia; and feeding the first and second flows of carbon dioxide and the ammonia to a urea synthesis unit to produce a flow of urea by fully utilizing the carbon dioxide.

The present invention relates to a compound represented by formula (I) or a stereoisomer, tautomer, solvate or pharmaceutically acceptable salt of a compound represented by formula (I), TIFF2026503201000033.tif3981X1, X2 and X3 are each independently an optionally substituted C1-C 15 alkylene, and R and R are each independently an optionally substituted C-C 40 Alkyl, optionally substituted C-C 40 Heteroalkyl, optionally substituted C-C 40 Alkenyl, optionally substituted C-C 40 Heteroalkenyl, optionally substituted C-C 40 Alkynyl or optionally substituted C-C 40 The present invention provides a compound comprising heteroalkynyl, wherein R3, R4, R5, and R6 are each independently H, halogen, or optionally substituted C1-C3 alkyl, and the substituents are independently selected from halogen, -OH, -SH, -NH2, -NO2, cyano, and C1-C3 alkyl, which has the advantages of low cytotoxicity, strong delivery ability, and strong immunostimulatory effect.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a memantine derivative and a synthesis method and application thereof. The memantine derivative comprises an intermediate structural formula I, an intermediate structural formula II, an intermediate structural formula III and a structural general formula, Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1 and R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the memantine derivative provided by the invention, a memantine group is combined with an OAB-14 partial structure to change a parent nucleus structure, so that the drug activity is improved. The invention also provides a synthesis method of the compound, and the obtained compound is used for treating Alzheimer's disease and Parkinson's disease.

The present disclosure relates to a high pressure carbamate condensing device for a urea plant, a urea plant and a urea production method. The device comprises a first U-shaped tube bundle arranged around a second U-shaped tube bundle.

The present application relates to the technical field of urea preparation, and discloses an energy-saving urea production system, a carbon dioxide stripping tower and a high-pressure ammonia ejector are connected with a first high-pressure methylamine condenser, a second high-pressure methylamine condenser is connected between the first high-pressure methylamine condenser and a urea synthesis tower, the second high-pressure methylamine condenser can be connected with a carbon dioxide compressor, and the urea synthesis tower is connected with the upper portion of the carbon dioxide stripping tower to input urea mixture into the carbon dioxide stripping tower. The energy-saving urea production system improves the recovery rate and utilization rate of the synthesis reaction heat through the addition of the second high-pressure methylamine condenser.

The invention discloses a cycloalkane substituted amine derivative as well as a preparation method and application thereof. Specifically disclosed is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The cycloalkane substituted amine derivative provided by the invention has good 5-HT2A receptor agonistic activity and a wide application prospect. # imgabs0 #

The invention provides a diurea diol chain extender, light-cured polyurethane-urea acrylate as well as a preparation method and application of the light-cured polyurethane-urea acrylate. The preparation method comprises the following steps: reacting a diisocyanate compound with an alcohol amine compound, which have different structures, to generate a diurea diol chain extender containing two ureido groups; high-performance light-cured resin, namely light-cured polyurethane-urea acrylate, with a main chain containing ureido is prepared from the diurea diol chain extender, a diisocyanate compound, polyhydric alcohol and a photosensitive end-capping reagent in the presence of a catalyst, an organic solvent and a polymerization inhibitor. According to the preparation method disclosed by the invention, ureido is controllably introduced into a main chain of the light-cured resin under a mild condition; the prepared polyurethane-urea acrylate shows higher tensile strength and modulus under the double hydrogen-bond interaction of carbamido, the hardness of a coating is remarkably improved, and the polyurethane-urea acrylate is suitable for a light-cured coating material or a blocky material.

Disclosed is a process for the production of an aqueous urea solution suitable for use as a Diesel Exhaust Fluid (DEF), wherein a condensate of off-gas obtained from further purifying an aqueous urea stream in a treatment section adapted to produce DEF, is sent to an LP dissociation section, thereby the removal of ammonia therefrom. This enables water obtained from such condensate to be recirculated to the DEF purification section, and prevents an unwanted build-up of water in recirculation to urea synthesis.

Method for producing solid urea by granulation, wherein the granulation is fed with liquid urea having a purity greater than 98% by weight and not containing formaldehyde.

To provide a lipid nanoparticle of which lipid ingredient comprises a new class of an ionizable cationic lipid compound, a method of preparing the lipid nanoparticle, a pharmaceutical composition of the lipid nanoparticle, and the use of the lipid nanoparticle or pharmaceutical composition in the delivery of a biologically active substance such as nucleic acid.SOLUTION: The disclosure provides a nanoparticle composition comprising a lipid ingredient, and optionally a load; where the lipid ingredient comprises the following components in the molar percentages: ionizable cationic lipids 20 mol% to 85 mol%; structure lipids 10 mol% to 75 mol%; neutral lipids 1.0 mol% to 30 mol%; polymer lipids 0.25 mol% to 10 mol%, where the ionizable cationic lipid is a compound of formula (IV), or a pharmaceutically acceptable salt, isotopic variant, or tautomer thereof.SELECTED DRAWING: None

The invention relates to a device for synthesizing urea, comprising an ammonia source 10 and a urea synthesis unit 20 wherein the ammonia source 10 is connected to the urea synthesis unit 20 by means of a reactant line 30, characterized in that the device comprises an ammonia turbine 40 wherein the ammonia source 10 is connected to the ammonia turbine 40 by means of a fuel line 50, and the ammonia gas turbine 40 is connected to the urea synthesis unit 20 through a steam pipeline 60.

The present disclosure provides system and method for synthesis of green ammonia and other nitrogenous fertilizers derived from it including urea and nitric acid (as well as others that may be produced by any combination / reaction of these) by coupling renewable energy and Carnot battery with Solid-Oxide Electrolyser Cell (SOEC) and Direct Air Capture (DAC). 5 The system provides a solution for round-the-clock renewable energy using Carnot battery that provides both heat and power to run SOEC. The heat from Carnot battery is used by DAC to capture carbon dioxide from air. A nitrogen-oxygen generator may produce nitrogen using continuous power from Carnot battery. Ammonia may be produced by using hydrogen from SOEC, and nitrogen from the nitrogen-oxygen generator. Urea may be produced using 0 carbon dioxide from DAC and ammonia. Ammonia and oxygen from SOECs and nitrogen- oxygen generator may be used for synthesis of nitric acid, and other nitrogenous fertilizers. The process heat from ammonia and nitric acid synthesis is recycled back to the Carnot battery.

The present application belongs to the technical field of condensate, and particularly relates to a non-peptide small molecule condensate and preparation and application thereof. The present application provides a non-peptide small molecule condensate which is prepared by taking a small molecule shown in formula I as a precursor, wherein Y and Z are each independently NH, O or S, R = or X = O or S; R1 and R2 are each independently selected from H, C 3‑20 alkyl, -C 1‑8 alkylene-phenyl, -C 1‑8 alkylene-5-10-membered heteroaryl, -C 1‑8 alkylene-S-C 1‑8 alkyl, -C 1‑8 alkylene-SH, -C 1‑8 alkylene-O-C 1‑8 alkyl or -C 1‑8 alkylene-NH-C 1‑8 alkyl; and R1 and R2 are not H at the same time. The obtained condensate not only has good spontaneous non-classical fluorescence characteristics, but also has the abilities of drug loading and controllable release, and shows excellent resistance to enzymatic hydrolysis and good biocompatibility. Formula I