974results about "Urea derivatives preparation" patented technology

The invention provides a VEGFR2-HDAC6 dual inhibitor containing chalcone fragments as well as a preparation method and application of the VEGFR2-HDAC6 dual inhibitor, and relates to the technical field of medicinal chemistry. The invention discloses a VEGFR2-HDAC6 dual inhibitor containing chalcone fragments. The structural formula of the VEGFR2-HDAC6 dual inhibitor is shown as a formula A, according to the invention, the VEGFR2-HDAC6 dual inhibitor containing the chalcone fragment and having a novel structure is designed and synthesized by utilizing a splicing principle, the anti-proliferative activity test is carried out on cervical cancer cells Siha and chronic granulocytic leukemia cells K562, and the result shows that the VEGFR2-HDAC6 dual inhibitor containing the chalcone fragment provided by the invention has relatively good inhibitory activity on the Siha cells and the K562 cells.

The invention discloses an intumescent nitrogen-phosphorus flame retardant and a preparation method thereof. The method comprises the following steps: reacting a cyanuric acid derivative with polyphosphoric acid to obtain a product, and carrying out salt forming reaction on the product and an amine compound to obtain the intumescent nitrogen-phosphorus flame retardant. The method is simple in synthesis step, high in yield, free of toxic volatile matters and suitable for industrial production. The obtained flame retardant has high nitrogen and phosphorus content, shows good expansion capacity when meeting fire, is good in compatibility with various water-based adhesives, is not prone to moisture absorption and has good application prospects.

The invention discloses a class of radiopharmaceutical labeled precursors targeting prostate specific membrane antigens, the structure of the radiopharmaceutical labeled precursors is shown as the following: # imgabs0 #, a precursor reagent RESCA-PSMA-1802 targeting prostate specific membrane antigens is synthesized for the first time, the reagent can be labeled by using an 18F-Al method to prepare a positron imaging agent 18FAl-RESCA-PSMA-1802, and the reagent can be used for preparing the prostate specific membrane antigens. The polymer has good stability and biological activity in vivo and in vitro, has good targeting property on prostate cancer cells, can reflect tumor recurrence or metastasis conditions, and is very suitable for PET imaging.

The invention belongs to the technical field of OAB-14 medical chemistry and preparation thereof, and particularly relates to a crystal form D of OAB-14 and a preparation method thereof. The preparation method of the crystal form D of OAB-14 comprises the following steps: adding OAB-14 into a solvent, and carrying out suspension pulping, heat preservation stirring, suction filtration and drying to obtain the crystal form D. The solvent is one of THF (tetrahydrofuran), MeOH (methanol), EtOH (methanol), EA (ethyl acetate) and MTBE (methyl tert-butyl ether). The suspension pulping temperature is 15 to 25 DEG C. And the heat-preservation stirring time is 1-5 days. After the OAB-14 is added into the solvent, the concentration of the OAB-14 is 0.005 g / mL to 0.01 g / mL. According to the preparation method of the crystal form D of OAB-14 provided by the invention, the crystal form D is an anhydrous crystal form with high crystallinity, high dissolution rate and high stability.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a method for converting OAB-14 crystal form C into crystal form A. The method for converting the OAB-14 crystal form C into the crystal form A comprises the following steps: (1) adding a crystal form C sample of OAB-14 into a reaction container, adding a solvent and alkali, and uniformly stirring; the alkali is organic alkali or inorganic alkali; (2) heating to reflux, and keeping the temperature and refluxing; and (3) cooling, crystallizing, performing suction filtration, and directly drying the obtained filter cake or adding water, pulping, performing suction filtration, and drying the filter cake again to obtain the OAB-14 crystal form A. The method for converting the OAB-14 crystal form C into the crystal form A is simple in process and high in conversion rate.

The invention relates to the technical field of fine chemical engineering, and provides a method for synthesizing O-methyl-N-nitroisourea by a micro-channel reactor, which comprises the following specific steps: adding nitric acid into a four-neck bottle for cooling, dropwise adding fuming sulfuric acid, controlling the temperature of a mixed solution, adding sulfuric acid into the four-neck bottle, and reacting for 2-4 hours; stirring and a low-temperature constant-temperature reaction bath are started to cool sulfuric acid, disulfate is put into a four-opening bottle to prepare a disulfate sulfuric acid solution, a mixed acid metering pump is started, a disulfate sulfuric acid solution metering pump is started, the disulfate sulfuric acid solution is mixed and enters a nitration micro-channel reaction device, and after heat preservation of nitration liquid is completed, the nitration liquid is dropwise added till the temperature is lowered to 0 DEG C in advance; the preparation method comprises the following steps: adding water into a reaction kettle, dropwise adding while stirring, continuously cooling and preserving heat after dropwise adding, carrying out suction filtration on eluted feed liquid, and washing a filter cake with chilled water to obtain an O-methyl-N-nitroisourea wet product, so that the defects of long production period, low effective productivity, lower safety coefficient and relatively higher safety risk of a traditional method for synthesizing O-methyl-N-nitroisourea are overcome.

The present invention relates to a novel process for the preparation of substituted phenylurea derivatives, in particular 3-(3,4-dichlorophenyl)-1,1-dimethylurea.

The invention discloses an efficient anti-crystallization urea solution for vehicles and a preparation method thereof, and belongs to the technical field of preparation of urea solutions for vehicles, the preparation method comprises the following steps: preparing an inclusion compound, hydrolyzing and crystallizing, dissolving, filtering, finely filtering and ultra-filtering; the hydrolytic crystallization method comprises the following steps: mixing industrial urea and three-stage water, stirring at 70-75 DEG C for 30-40 minutes, carrying out first gradient cooling and second gradient cooling, adding an inclusion compound, carrying out third gradient cooling and fourth gradient cooling, preserving heat, centrifuging, and taking a precipitate. During preparation, the industrial urea is used as a raw material, the prepared efficient anti-crystallization urea solution for the vehicle is low in impurity content, free of precipitates and high in urea yield, the urea yield is slightly influenced by the impurity content in the industrial urea, and when precipitates in the urea solution are removed through an ultrafiltration method, the membrane flux is slightly influenced by the precipitate content in the urea solution; the problem of membrane pollution can also be avoided.

The invention discloses a system for mixing, utilizing and recycling waste heat in urea production, and relates to the technical field of recycling, which comprises the following steps of: before urea production starts, initially setting a heat energy distribution proportion and operating parameters, and collecting urea production data by deploying various sensors; based on urea production data, a heat energy demand prediction model is constructed, and waste heat is divided into different temperature levels; according to the prediction result, the distribution proportion of waste heat of different temperature levels is dynamically adjusted; according to the dynamically-adjusted heat energy distribution proportion, waste heat of different temperature levels is utilized in a gradient mode through a multi-level heat exchanger; waste heat which cannot be utilized immediately is guided into the phase change material to be stored, released according to production requirements and distributed again; through construction of the heat energy demand prediction model and application of the phase change material, effective division and efficient gradient utilization of waste heat of different temperature levels are achieved, and continuous supply of heat energy in the production process is ensured.

Ammonia, methanol, Fischer Tropsch products, and derivatives thereof are made by using hydrogen and oxygen supplied from an electrolyzer that is at least partially powered by renewable power, resulting in green process and systems that produce green products disclosed herein. A process using biomass and renewable energy includes producing an unshifted syngas from biomass and oxygen in a gasification unit, introducing water into an electrolyzer to produce an oxygen product and a hydrogen product, and introducing the oxygen product to the gasification unit. The electrolyzer is powered by renewable energy, and the oxygen product supplies at least a portion of the oxygen to the gasification unit.

The present invention (named: a class of aminonaphthoquinone derivatives and their preparation and sterilization, weeding and algae killing uses) relates to 33 2-chloro-3-aminonaphthoquinone formate, urea, amide and sulfonamide derivatives and their preparation methods, as well as their uses in sterilization, weeding and algae killing. The 33 2-chloro-3-aminonaphthoquinone formate, urea, amide and sulfonamide derivatives are generated by reacting 2,3-dichloronaphthoquinone with potassium cyanate, substituted alcohol or amine, or with sulfonamide; or by reacting 2-chloro-3-aminonaphthoquinone with different amides. These compounds can be used as fungicides to control tomato gray mold, or as herbicides to control weeds such as Amaranthus retroflexus and Crabgrass, or as algaecides to control algae.

The present invention provides an improved low-energy-consumption urea production process by CO2 stripping method. A part of the urea synthesis liquid is sent into the high-pressure CO2 stripper in the high-pressure decomposition and recovery system for stripping and decomposition, and then is sent into the medium-pressure pre-separator after being decompressed by the first hydraulic turbine or / and pressure reducing valve; another part of the urea synthesis liquid is directly sent into the medium-pressure pre-separator after being decompressed by the second hydraulic turbine or / and pressure reducing valve, and the urea solution at the outlet of the medium-pressure pre-separator is sent into the shell side of the urea decomposition heater; a part of the gas phase of the high-pressure CO2 stripper is sent into the high-pressure carbamate condenser, and another part is sent into the tube side of the medium-pressure decomposition heater, and the liquid phase at the outlet of the high-pressure ammonia ejector is also sent into the tube side of the medium-pressure decomposition heater. The carbamate liquid is sent into the high-pressure carbamate condenser after coming out of the tube side of the medium-pressure decomposition heater; the urea solution coming out of the shell side of the urea decomposition heater is sent into the medium-pressure urea rectifying column and then into the low-pressure rectifying column, and then into the slightly positive pressure flash tank. The process of the present invention is simple, low in cost and low in steam consumption.

The invention provides a compound containing a ureido structure, a negative photosensitive resin composition and a preparation method and application of the negative photosensitive resin composition. The compound containing the ureido structure can be used as a photo-crosslinking agent; when being added into the photosensitive resin composition, the compound can improve the resolution ratio and mechanical property of a photosensitive resin composition cured film and the adhesiveness with a base material, and can effectively inhibit the oxidation discoloration of a copper base material.

The invention belongs to the technical field of drug synthesis, and particularly relates to an adamantane derivative as well as a synthesis method and application thereof. The adamantane derivative comprises an intermediate structural formula I, an intermediate structural formula II and an intermediate structural formula III, and the structural general formula is as follows: Linker is substituted or unsubstituted C6-C10 aroyl, R1 is hydrogen or C1-C6 alkyl, R2 is hydrogen, C1-C6 alkyl or a nitrogen-containing or nitrogen-free structural fragment, or the integral structure of R1R2 is N-substituted heterocyclic pentyl or heterocyclic cyclohexyl. According to the adamantane derivative provided by the invention, an adamantane structure is combined with part of groups of OAB-14, and a parent nucleus structure is changed, so that the drug activity is improved. The invention also provides a synthesis method of the compound, the obtained compound is screened through cell viability research, and the compound has a potential synergistic effect in the aspects of preventing influenza and treating Alzheimer's disease.

The invention relates to a kettle residue recovery process of methyl carbamate, and belongs to the technical field of chemical engineering, the kettle residue recovery process of methyl carbamate comprises the following steps: adding the kettle residue of methyl carbamate into water, stirring for dissolving, adding chloroform, extracting, standing for layering, taking an oil phase dissolved with methyl carbamate at the lower layer, cooling to room temperature, filtering, washing, and drying to obtain the methyl carbamate. Drying to constant weight to obtain recycled methyl carbamate; and adjusting the pH value of an upper water phase composed of impurities such as urea, biuret and triuret to 7.5-8 by using a pH regulator, introducing into a sealed reaction tank filled with a modified mesoporous molecular sieve, adsorbing at normal temperature and normal pressure, filtering, and treating the filtrate at 60-80 DEG C to obtain the recycled and treated urea. The whole preparation process is simple and controllable, and the methyl carbamate and the urea in the kettle residues of the methyl carbamate are recycled.

A hydrogen production system for producing a hydrogen gas product includes a geologic hydrogen source configured to provide a feedstock comprising hydrogen, nitrogen, and helium and purification equipment comprising two or more of: a pressure swing adsorption (PSA) device; a guard bed; a separation membrane; a reactive membrane; or a cryogenic separation device. The purification equipment is configured to receive the feedstock from the geologic hydrogen source and produce a hydrogen gas product, and production of the hydrogen gas product exhibits a carbon intensity score less than 3.0 kg CO2 eq / kg H2.

This invention discloses a method for improving the yield of urea phosphate in the preparation of wet-process phosphoric acid. The method involves mixing a crystallizer with wet-process phosphoric acid and urea, reacting the mixture, and then cooling, crystallizing, filtering, and drying to obtain urea phosphate. Alternatively, wet-process phosphoric acid is mixed with urea and reacted. After the reaction, a crystallizer or a urea phosphate mother liquor containing the crystallizer is added, followed by cooling, crystallizing, filtering, and drying to obtain urea phosphate. The crystallizer is one or a mixture of two or more of ethylene glycol methyl ether, ethylenediaminetetraacetic acid, and citric acid in any proportion. The urea phosphate produced by this method is in crystalline form, meeting the industrial urea phosphate standard (GB / T27805-2011), satisfying market demand, and featuring a low-cost crystallizer with flexible addition methods, making it very convenient for practical production.

The invention relates to the technical field of fertilizer manufacturing, in particular to a humic acid-containing urea formaldehyde liquid slow-release nitrogen fertilizer which is prepared from the following materials in parts: 30-70 parts of urea, 25-50 parts of formaldehyde, 1-15 parts of alkali compounds, 6-30 parts of ammonia and 1-10 parts of humic acid. The invention relates to a preparation method and application of a liquid slow-release nitrogen fertilizer containing humic acid type urea formaldehyde, and the preparation method comprises the following steps: excessive formaldehyde reacts with urea and ammonia water to generate monomethylol urea and dimethylol urea, and then a hydroxymethyl Uron ring is generated; formaldehyde, ammonia water and urea are continuously added for a reaction, and hydroxymethyl urea is converted into methylene diurea and dimethylene triurea; after cooling, continuously adding a small amount of ammonia water into the reaction kettle; and finally adding humic acid to obtain the liquid slow-release nitrogen fertilizer containing humic acid type urea formaldehyde. After the reaction is completed, the pH value of the solution is 8.0-11.0, and the reaction temperature is 50-95 DEG C. The liquid slow-release nitrogen fertilizer containing the humic acid type urea formaldehyde is high in stability, stable in storage component at-20 DEG C and 54 DEG C, free of gas expansion and crystallization, invariant in storage environments with cold winter and high temperature in summer, and suitable for popularization and application in different areas and different seasons; the product is high in nitrogen content, long in slow release period and high in absorption and utilization efficiency, and effectively solves the problems of high nitrogen fertilizer consumption, short lasting period and high loss rate in agricultural growth.

The present invention relates to a process for the production of melamine and the production plant including an off-gas condensation step carried out at a pressure of 70 to 220 bar by feeding gaseous and liquid streams at the same pressure, converting the liquid stream from the off-gas condensation step to a first stream, followed in succession by a high pressure decomposition step, a medium pressure decomposition step, a low pressure decomposition step, and urea concentration step.

The invention relates to a jet reactor for HDI biuret production and application thereof.The jet reactor for HDI biuret production comprises a reactor body and a feeding pipe, the reactor body is provided with an HDI feeding channel, a reaction chamber and a flash chamber which are sequentially communicated, the reaction chamber is provided with an expansion section, and the expansion section is arranged close to an outlet of the HDI feeding channel; at least part of the feeding pipe is arranged in the HDI feeding channel and extends towards an outlet of the HDI feeding channel, a rotating rod is arranged in the feeding pipe in a penetrating mode, one end of the rotating rod is in transmission connection with a driving mechanism, the driving mechanism drives the rotating rod to rotate, the other end of the rotating rod is provided with a rotating head with the outer surface in an expanded shape, and at least part of the rotating head extends out of an outlet of the feeding pipe. When the jet reactor is applied to the production of HDI biuret, the blockage of equipment or pipelines can be effectively avoided, the high-temperature decomposition reaction of HDI can be effectively avoided, and the safety risk is reduced.

The invention relates to the field of preparation of guanidine or derivatives thereof, and particularly discloses high-purity creatine monohydrate and a preparation method thereof. The preparation method comprises the following steps: sequentially carrying out condensation reaction, acidolysis reaction and hydrolysis reaction on dimethyl sulfate and urea, cooling, crystallizing and filtering to obtain O-methylisourea hydrogen sulfate, and then reacting a sarcosine salt aqueous solution with the O-methylisourea hydrogen sulfate under the conditions that the temperature is 45-65 DEG C and the pH value is 10-12 to obtain the sarcosine salt. And performing post-treatment to obtain the high-purity creatine monohydrate. The preparation method has the advantages of being low in raw material cost, easy to transport and store and rich in source, byproducts in the reaction process are few, danger is low, the yield and purity are high, the industrial requirement is met, and the preparation method is suitable for large-scale industrial production.

The disclosure pertains to a high pressure carbamate condensation apparatus for a urea plant, a urea plant, and a urea production method. The apparatus comprises a first U-shaped tube bundle arranged around a second U-shaped tube bundle.

The invention provides a method for preparing carbon isotope labeled urea by taking divalent carbonate as a raw material, and belongs to the technical field of helicobacter pylori detection. The method comprises the following steps: S1, mixing acid with divalent carbonate powder, and collecting generated carbon dioxide; s2, drying the carbon dioxide, and introducing a nitrogen source solution until the carbon dioxide is saturated to obtain a reaction solution; s3, sequentially carrying out heating reflux, cooling, filtering, solvent removal and vacuum concentration on the reaction liquid to obtain carbon-labeled C (NTMS) 2; s4, dissolving the carbon-labeled C (NTMS) 2 in 1, 4-dioxane, then adding a hydrogen fluoride aqueous solution and oxalic acid, carrying out a reflux reaction, collecting a solid, and drying to obtain carbon isotope labeled urea; the divalent carbonate in the S1 is marked by carbon 13 or carbon 14. The high-purity carbon isotope labeled urea is prepared by adopting the carbon labeled divalent carbonate as the raw material, the preparation condition is mild, the synthesis process is convenient, green and environment-friendly, and the method is suitable for industrial production.

The invention belongs to the technical field of synthesis, and particularly relates to a synthesis method of urea [14C]. The synthesis method of the urea [14C] comprises the following steps: (1) reacting carbonate [14C] with ammonia gas to obtain cyanamide salt [14C]; (2) hydrolyzing the cyanamide salt [14C] obtained in the step (1) with concentrated sulfuric acid at the hydrolysis temperature of 35-45 DEG C; and (3) adjusting the pH value of the hydrolysate obtained in the step (2) with ammonia water, concentrating and purifying to obtain urea [14C]. The synthesis method provided by the invention has the advantages of mild conditions, efficient reaction, high product yield (up to 95% or above), high purity (the chemical purity is greater than or equal to 99%) and the like, and is suitable for large-scale preparation of key raw materials of helicobacter pylori diagnostic reagents.

The objective of the present invention is to provide a method for producing a halogenated carbonyl safely and efficiently. The method for producing a halogenated carbonyl according to the present invention is characterized in comprising the step of applying ultrasound to a composition containing a C1-4 halogenated hydrocarbon having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen to decompose the C1-4 halogenated hydrocarbon.

The invention belongs to a urea synthesis system using liquid carbon dioxide and a urea synthesis method. Comprising a urea synthesis tower, the urea synthesis tower is respectively connected with a liquid ammonia pipeline and a carbon dioxide gas pipeline, the carbon dioxide gas pipeline is connected with an outlet of a liquid-phase carbon dioxide delivery pump through a liquid-phase carbon dioxide vaporization unit, and an inlet of the liquid-phase carbon dioxide delivery pump is connected with a liquid-phase carbon dioxide delivery pipeline; liquid carbon dioxide is directly used as a raw material, a liquid-phase carbon dioxide delivery pump is used for pressurization, and gasification is carried out after pressurization, so that the liquid carbon dioxide meets the requirements of a urea synthesis tower, and the characteristics of saving urea synthesis energy consumption, reducing the use amount of circulating water and reducing the occupied area of equipment are achieved.

The invention provides a low-energy-consumption urea synthesis system and method, and the system comprises a high-pressure synthesis unit which comprises a synthesis tower, a condensation part and a stripping tower; cO2 gas, liquid ammonia and methylamine liquid from the condensation part are introduced into the synthesis tower for a synthesis reaction; the synthesis tower is connected with the stripping tower to introduce the liquid generated by the synthesis reaction into the stripping tower; the synthesis tower is connected with the condensation part to introduce NH3 and CO2 gas generated by synthesis reaction into the condensation part; the stripping tower is connected with the condensing part to introduce NH3 and CO2 into the condensing part; a medium-pressure decomposition recovery unit; a low-pressure decomposition recovery unit; and a urea solution processing unit. By simplifying the high-pressure synthesis unit for urea synthesis, arranging the efficient medium-pressure decomposition and recovery unit, designing and transforming the urea production energy-saving system and optimizing the production process, the energy consumption of urea production is greatly reduced, and the urea synthesis process meets the production requirements of energy conservation and low energy consumption.

The invention relates to a method and device for preparing urea through photocatalysis and piezoelectric catalysis of CO2, and the method comprises the following steps: adding a catalyst into water, introducing CO2 and N2 into the water, and reacting under the action of illumination and ultrasonic waves to obtain a urea solution; the light intensity of illumination ranges from 200 mW / cm < 2 > to 300 mW / cm < 2 >; the catalyst is selected from one or more of CdS (cadmium sulfide), ZnO (zinc oxide), WO3 (tungsten trioxide), BiOCl (bismuth oxychloride) and Bi4NbO8Cl (bismuth oxychloride). The technical problem to be solved is to provide a method for preparing urea by photocatalysis and piezoelectric catalysis of CO2, according to the method, under the action of illumination, ultrasonic waves and a catalyst, photocatalysis and piezoelectric catalysis of CO2 are combined, urea synthesis can be carried out at normal temperature and normal pressure, the yield of urea can be improved, and a new direction is developed for green and efficient synthesis of urea. Furthermore, the device can integrate air carbon capture coupling photocatalysis and piezoelectric catalysis CO2 preparation of urea into a set of continuous device, a large amount of energy input is not needed, multi-step separation can be avoided, the device is simple, and the cost can be greatly reduced.

The embodiments herein provide a single-step method for the conversion of a mixture of gases or flue gas containing CO2, N2 and H2O into Urea using plasma as an energy source. The gas mixture is exposed to high voltage AC or DC or pulsed or subjected to radiofrequency electric field to create plasma state of the said gas mixture in the presence of catalysts. The electrical species (ions, radicals etc.) of gases are introduced in electrically activated or ionized water containing solvated electrons, radicals or ions of Hydrogen and other ions or radicals. The Urea is synthesized in such a reducing water media by co-reduction of Amine ions or ions of Nitrogen Oxides, and ions of oxides Carbon. The invention also discloses a method to utilize electrically activated nano-droplets of water to increase the surface area of interaction between a mixture of gases under a plasma field and water. Additionally, the invention discloses that the single-step method disclosed here can also be utilized for synthesizing Ammonia (NH3). The disclosed method can help in the reduction of CO2 emissions from industries or can reduce CO2 concentration in the air.

A process includes feeding atmospheric air to an air separation unit to produce a flow of nitrogen and a flow of oxygen; combining the oxygen with a hydrocarbon flow and water in an auto-thermal reformer to produce a retentate stream to a membrane water gas shift reactor (M-WGSR); generating, from the retentate stream to the M-WGSR, a permeate stream from the M-WGSR that includes a first flow of carbon dioxide and a first combined flow of hydrogen and nitrogen; feeding a retentate stream to a membrane steam methane reformer (M-SMR) to produce a permeate stream from the M-SMR that includes a second flow of carbon dioxide and a second combined flow of hydrogen and nitrogen; feeding the first and second combined flows to an ammonia synthesis unit to produce ammonia; and feeding the first and second flows of carbon dioxide and the ammonia to a urea synthesis unit to produce a flow of urea by fully utilizing the carbon dioxide.