16 results about "Chronic fatigue" patented technology

The invention belongs to the technical field of genes, and discloses intelligent wearable equipment for real-time monitoring and intervention of chronic fatigue syndromes. The equipment comprises a user input module, an intelligent screening module, a control center, a dynamic risk assessment module, a health monitoring module, a cloud server, an intelligent scheme generation module, a display module, a sound production module, an intelligent supervision module and an intelligent optimization module. According to the method, through a multi-modal data fusion technology, the accuracy of CFS early recognition is remarkably improved, and clinical verification shows that the screening accuracy reaches 92.3%; due to the innovative dual-mode design (treatment mode / conventional monitoring mode), the system can flexibly adjust the monitoring intensity according to user requirements, and the energy consumption is optimized while the effect is ensured; a cognitive behavior therapy is digitalized, psychological intervention is implemented in an intelligent interaction mode, and user compliance is improved by 56%.

This invention discloses a chronic fatigue state monitoring system and method based on a state-space model, comprising a real-time perception layer and a longitudinal analysis layer. The real-time perception layer processes high-frequency raw data streams and outputs daily state vectors that quantify the user's overall fatigue state for the day. The high-frequency data streams include user facial video streams from an image sensor and computer event streams from a human-computer interaction device. The longitudinal analysis layer receives and processes long-term sequences composed of multiple daily state vectors, autonomously learns the user's fatigue accumulation and recovery patterns through end-to-end time-series analysis using a state-space model, and outputs predictive chronic fatigue risk monitoring results. This invention achieves end-to-end automated monitoring and prediction, from millisecond-level behavioral data acquisition to long-term health trend analysis, through the collaborative work of the real-time perception layer and the longitudinal analysis layer.

The invention provides a bifidobacterium longum and longan aril composition capable of synergistically relieving chronic fatigue, the bifidobacterium longum is named as BB36, the preservation number is CGMCC (China General Microbiological Culture Collection Center) NO.34123, and the preservation date is April 8, 2025. By improving the levels of stress hormones and neurotransmitters and reducing the serum inflammation level, the strain significantly improves the chronic fatigue symptom and improves the athletic ability; the invention further develops a bifidobacterium longum and longan aril composition capable of synergistically relieving chronic fatigue, and through compounding of probiotics and longan aril extract, it is found that the probiotics and the longan aril extract can cooperate with each other, and the composition has a synergistic effect in relieving chronic fatigue.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for invigorating kidney, strengthening yang and resisting fatigue and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 20 to 30 parts of cornu cervi pantotrichum, 20 to 30 parts of penis cervi, 15 to 25 parts of radix rehmanniae recen, 10 to 20 parts of rhizoma dioscoreae, 5 to 15 parts of cortex moutan, 15 to 25 parts of poria cocos, 10 to 20 parts of rhizoma alismatis and 5 to 15 parts of tetrapanax papyriferus. The traditional Chinese medicine composition prepared by the invention aims at soreness and weakness of waist and knees, intolerance of cold and cold limbs and sexual dysfunction caused by insufficiency of kidney-yang, treats both symptoms and root causes through the compatibility of warming yang and nourishing yin, and can enhance immunity, improve chronic fatigue and relieve physical exhaustion at the same time.

The disclosure relates to methods, compositions, and combinations for detoxification in a patient comprising performing therapeutic plasma exchange (TPE) on the patient. The disclosure also relates to methods, compositions, and combinations for removing toxins in a patient as a result of chronic exposure to the toxins, comprising performing one or more TPE sessions on the patient and administering an oral composition to the patient. Tire methods, compositions, and combinations of the disclosure may also be used to replenish biomarkers indicative of a healthy state of the body in order to improve immune system function or patient longevity, and / or reduce oxidative stress or inflammation. The methods, compositions, and combinations of the disclosure may also be used to reduce the level of atherosclerosis, improve cognitive function, prevent early cancer development, promote immune health, and / or treat health conditions or diseases such as autoimmune diseases, cancers, Alzheimer's disease, Parkinson's disease, chronic fatigue syndromes, or fibromyalgia. Additionally, the methods, compositions, and combinations of the disclosure may comprise an intravenous supplementation, wherein each TPE session is followed by administration to the patient of an IV composition. The disclosure further relates to oral compositions and IV compositions for use in the methods, compositions, and combinations of the disclosure.

The invention discloses application of lactobacillus rhamnosus to preparation of a product for improving cognitive impairment or neuroinflammation caused by chronic fatigue. The lactobacillus rhamnosus BD4047 is an edible safety strain, and can improve cognitive impairment of a chronic fatigue animal model by reversing short-term spatial learning memory ability and working memory ability; by improving the indole level, lowering the IL-33 level and balancing intestinal flora, the neuroinflammation of a chronic fatigue animal model is relieved, so that the lactobacillus rhamnosus BD4047 can be used as an active ingredient for developing functional foods such as fermented milk, lactobacillus beverages, probiotic powder, viable bacteria water, milk powder and cheese, and has large-scale production and market popularization prospects.

The instant invention relates to the use of a substance with phosphodiesterase-7 inhibitory activity (PDE7 inhibitor) as active ingredient in a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of different diseases, syndromes, disease states, or conditions associated with chronic fatigue, exhaustion and / or exertional intolerance using PDE7 inhibitors alone or in combination with other therapeutic agents.

The instant invention relates to the use of a substance with phosphodiesterase-7 inhibitory activity (PDE7 inhibitor), such as spiro[[1,3]oxazolo[5,4f-]quinazoline-9,1′-cyclohexan)-7-one derivatives, as active ingredient in a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of different diseases, syndromes, disease states, or conditions associated with chronic fatigue, exhaustion and / or exertional intolerance using PDE7 inhibitors alone or in combination with other therapeutic agents.

The invention provides a medicine pillow for regulating mind, liver, spleen, lung and kidney based on the theory of five mind of traditional Chinese medicine, and comprehensive regulation of mind stabilization, liver soothing, spleen transformation, lung and kidney qi absorption is realized by implanting a traditional Chinese medicine composition and cooperating with acupoint stimulation. Through clinical verification, the effective rate on insomnia, anxiety and chronic fatigue is greater than 85%. The tea is beneficial to resuscitation and intelligence development, improves learning and memory, and has improvement effects on calming, convulsion resistance, depression resistance, arteriosclerosis resistance, hyperlipidemia resistance, hypertension and cardiovascular and cerebrovascular diseases.

The invention discloses a clinical application for treating chronic fatigue syndrome by combining traditional Chinese medicine with modern physiotherapy technology, which comprises the following steps: continuously collecting meridian point electric signals, electroencephalogram signals and peripheral nerve electrophysiological signals of a patient, and synchronously recording traditional Chinese medicine taking information; inputting the signals into a meridian-nerve electrophysiology coupling model to calculate a coupling characteristic parameter set; calling a fatigue factor time sequence prediction algorithm, and predicting a future fatigue factor change trend in combination with historical data; adjusting chronic fatigue brain-body interaction intervention system parameters and a traditional Chinese medicine taking scheme according to a prediction result; alternately implementing electroencephalogram adjustment and meridian point electrical stimulation intervention according to the adjusted parameters; after intervention, signal acquisition and analysis are periodically repeated, and a result optimization scheme is compared to form a closed loop. According to the application, personalized treatment is achieved through multi-signal integration analysis and dynamic parameter adjustment, the advantages of long-acting conditioning of traditional Chinese medicine and rapid intervention of modern physical therapy are combined, and the treatment accuracy and effect are effectively improved.

The invention relates to the technical field of traditional Chinese medicines, relates to new application of a traditional Chinese medicine composition, and in particular relates to application of the traditional Chinese medicine composition in preparation of a medicine for preventing and / or treating chronic fatigue syndrome. The traditional Chinese medicine composition is prepared from cassia twig, white peony root, honey-fried licorice root, ginger, jujube, ginseng, Chinese angelica, salted morinda officinalis and dwarf lilyturf tuber. The traditional Chinese medicine composition provided by the invention can obviously prolong exhaustive swimming time of mice and rats with chronic fatigue syndromes, reduce serum inflammatory factor levels of fatigue mice and rats and reduce serum MDA content of rats, and has a good treatment effect on chronic fatigue syndromes.

The invention discloses an anti-fatigue traditional Chinese medicine composition as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine, the anti-fatigue traditional Chinese medicine composition comprises the following components in parts by weight: 5-100 parts of malt, 5-30 parts of codonopsis pilosula, 5-50 parts of astragalus membranaceus, 2-20 parts of pericarpium citri reticulatae, 2-20 parts of liquorice and 1-10 parts of jujube. The anti-fatigue traditional Chinese medicine composition can regulate qi and blood and harmonize liver and spleen, and is suitable for fatigue sub-health and chronic disease fatigue people with qi and blood deficiency and liver and spleen disharmony. Meanwhile, the traditional Chinese medicine composition is prepared from medicinal and edible medicinal materials, so that the safety of the product is ensured, and the traditional Chinese medicine composition is mild in medicine property, can soothe liver and regulate qi without hurting yin and consuming qi, can invigorate qi and blood without moistening greasy stomach, has long-term applicability, is particularly suitable for sub-healthy people in a pressure environment for a long time, and can be taken for a long time to achieve the effects of relieving fatigue and relieving pain by tonifying qi and blood and soothing viscera. And the anti-fatigue / anti-fatigue capability is fundamentally enhanced.

This invention relates to a sports fatigue monitoring and management system and a sports fatigue monitoring and management method. Firstly, it provides a sports fatigue monitoring and management system, including an electronic fabric patch, a multimodal sensing module, and a data transmission and interaction module. The electronic fabric patch can be attached to the skin surface of a subject, and its electrode structure forms a multimodal sensing module capable of detecting flowing sweat or directly monitoring the subject's body. The electronic fabric patch uses porous fabric and gradient micropillar structures to dynamically regulate the accumulation of trace amounts of sweat and the drainage of excessive sweat, simultaneously collecting multidimensional physiological and biochemical indicators such as electromyographic signals, electrolytes, metabolites, and hormones. Additionally, an AI assessment module is deployed, based on a multi-algorithm fusion model trained using observation data during the rest-exercise-recovery process, to identify six types of fatigue-related states and generate intervention plans. In some embodiments, this can reduce fatigue levels by 51.82%, accelerate chronic fatigue recovery, and is suitable for athlete training monitoring and rehabilitation patient exercise management.

The invention discloses a compound chewable tablet with anti-hypoxia activity and application of the compound chewable tablet, and belongs to the technical field of functional food and health care products. The compound chewable tablet is prepared by compounding an olive extract, a Chinese wolfberry fruit extract, an American ginseng extract, skim milk powder, microcrystalline cellulose, mannitol, citric acid, a sweetening agent, mint powder and a small amount of tabletting auxiliary materials according to a specific weight percentage. The chewable tablet preparation is good in taste, rapid in disintegration and high in bioavailability, the SOD and NO levels of an organism can be remarkably improved, oxidative stress indexes such as MDA and LDH are reduced, and the hypoxia tolerance is enhanced. And the nutritional powder is suitable for functional nutrition intervention of plateau people, mental workers, chronic fatigue state or sub-health people. The product takes plant extracts as main active ingredients, is high in safety and mild in process, and has good industrialization and market application prospects.

The invention discloses application of lactobacillus rhamnosus to preparation of a product for treating hippocampus injury caused by chronic fatigue. The invention discloses that the lactobacillus rhamnosus BD4047 has good neuron and synaptic protection capability for the first time, and can improve hippocampus neuron damage caused by chronic fatigue, increase the density of hippocampus neuron dendritic spines, increase the length of the dendritic spines and increase the number of branch intersection points of the dendritic spines; the synaptic injury caused by chronic fatigue is improved, the synaptic gap width is reduced, the thickness of a synaptic compact region is increased, the length of a synaptic active region is prolonged, the increase of the number of synaptic vesicles and the increase of the number of SYP spots are promoted, and a remarkable synaptic repair effect is achieved; in addition, mouse hippocampus microglial cell activation caused by chronic fatigue can be inhibited, hippocampus injury caused by chronic fatigue and diseases related to the hippocampus injury can be comprehensively improved, and therefore the composition has a wide prospect.

A fatigue state determination system (1) comprises: a means for acquiring time-series sensor data measured by a wearable sensor worn by a user; a means for acquiring user input data input by the user; and a determination means for quantitatively determining a mental fatigue state of the user on the basis of the sensor data and the user input data. The determination means includes a means for calculating a transient fatigue degree (E2), a chronic fatigue degree (E1), and a fatigue allowance degree (E3) as quantitative information of the mental fatigue state.