237 results about "Hyperlipidemia" patented technology

The invention provides a multi-source heterogeneous data integrated coronary heart disease accurate prediction method, which comprises the following steps: acquiring various physiological signals of a patient in real time, the physiological signals comprising ST segment change characteristics and basic cycle function parameters in electrocardiosignals, and obtaining a multi-source signal data set; according to the joint data set, analyzing instantaneous fluctuation characteristics of a vascular resistance index in a postprandial hyperlipemia window period, extracting a vascular resistance fluctuation amplitude from the instantaneous fluctuation characteristics, and if it is detected that the fluctuation amplitude exceeds a preset threshold range, marking the window as a high-risk time window; if the score value exceeds a preset threshold value, triggering a coronary heart disease early warning signal according to the comprehensive risk score value in combination with a feature mode of a coronary heart disease hidden period in historical data; and storing the current high-risk time window characteristics and the blood sugar and blood fat curve change trend through a triggered coronary heart disease early warning signal to obtain structured risk archive data.

A pharmaceutical composition comprising a first RNAi agent and a second RNAi agent, the first RNAi agent comprising one or more first and / or one or more first siRNA conjugates capable of inhibiting APOC3 mRNA; a second RNAi agent comprising one or more second siRNAs and / or one or more second siRNA conjugates capable of inhibiting PCSK9 mRNA; the weight ratio of the first RNAi agent to the second RNAi agent in the pharmaceutical composition is (10: 1)-(1: 10) based on the total amount of the siRNA and the siRNA group. The pharmaceutical composition and the treatment method can effectively treat and / or prevent diseases or symptoms related to hyperlipidemia.

Disclosed is a strain of Bifidobacterium longum subsp. longum named dipro-O. The Bifidobacterium longum subsp. longum dipro-O used in the present invention has the ability to overproduce BSH, the ability to reduce cholesterol, and the ability to metabolize tryptophan into indole-3-lactic acid, can effectively reduce body weight, significantly lower insulin resistance levels resulting from high-fat diets, reduce the expression of the inflammatory cytokine TNF-α, significantly lower the levels of total cholesterol (TC) and low-density lipoprotein (LDL) in the blood, and increase the level of high-density lipoprotein (HDL), and can ameliorate disorders of the gut microbiome structure. In addition, the strain can also have an ameliorating effect on other lipid metabolism-related diseases such as hyperlipidemia, thereby providing health interventions for the host's body weight, liver, intestinal health, and blood lipid levels. Moreover, pasteurized dipro-O can also have the effect of regulating lipid metabolism, further extending the range of applications of the strain.

The invention belongs to the technical field of health-care food, and particularly relates to a sacha inchi oil-based gel candy with functions of reducing hypertension, hyperglycemia and hyperlipidemia and a preparation method thereof, and the sacha inchi oil-based gel candy comprises the following components: 1) a main component: 30-70% of sacha inchi oil; 2) a blood fat reducing synergistic component which is one or a combination of more of 0.5%-5% of phytosterol, 0.1%-2% of a red yeast rice extract and 0.01%-0.5% of sugarcane octacosanol; 3) a hypoglycemic synergistic component, which comprises one or a combination of more of 5%-20% of inulin / fructo-oligosaccharide, 0.5%-5% of a bitter gourd extract, 0.5%-5% of a mulberry leaf extract and 10-200 [mu] g / grain of chromium; 4) an antihypertensive synergistic component, wherein the antihypertensive synergistic component is one or a combination of more of 500-5000FU / grain of nattokinase, 0.5-5% of a celery seed extract and 1-8% of a hawthorn extract; through scientific compounding, the sacha inchi oil and various synergistic components exert a combined effect, and meanwhile, auxiliary regulation is carried out on blood sugar, blood fat and blood pressure; the main components are derived from natural plant extracts or functional grease, so that the health-care product is high in safety and suitable for daily health care.

The invention provides application of qi and blood strengthening oral liquid in preparation of a medicine for improving hyperlipidemia, and belongs to the technical field of medicine preparations. According to the invention, the mass ratio relationship among the components and the preparation method thereof are researched, and especially in the preparation process, the traditional Chinese medicine components are extracted by means of high-pressure steam heating, vacuum concentration and the like under different pressures in batches and stages, so that the obtained oral liquid for consolidating qi and blood is high in content of effective components, and has a good effect on consolidating qi and blood. The oral liquid for consolidating qi and blood can significantly improve hyperlipidemia, and has potential clinical application value.

The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents such as small interfering RNA (siRNA) molecules, able to inhibit proprotein convertase subtilisin kexin 9 (PCSK9) gene expression. Also disclosed are pharmaceutical compositions that include PCSK9 RNAi agents and methods of use thereof. The PCSK9 RNAi agents disclosed herein may be conjugated to targeting ligands, including ligands that comprise N-acetyl-galactosamine, to facilitate the delivery to hepatocyte cells. Delivery of the PCSK9 RNAi agents in vivo provides for in vivo provides for inhibition of PCSK9 gene expression and thereby reduction of PCSK9 protein. The RNAi agents can be used in methods of treatment of diseases or disorders mediated at least in part by PCSK9 gene expression, including among others hypercholesterolemia, familial hypercholesterolemia including heterozygous familial hypercholesterolemia (HeFH) and homozygous familial hypercholesterolemia (HoFH), familial hypobetalipoproteinemia, hyperlipidemia, coronary artery disease, polygenic dyslipidemia, heart disease, cardiovascular disease (CVD) including clinical atherosclerotic cardiovascular disease (ASCVD).

The invention discloses a myocardial ischemia reperfusion injury animal model construction method and application thereof in the technical field of model animal preparation. The method comprises the steps of hypertension and hyperlipidemia pretreatment, standardized ischemia-reperfusion operation, immune microenvironment regulation and control and model evaluation and verification. According to the invention, model construction is carried out on an integrated model operation table, so that a standardized ischemia-reperfusion process is realized, reproducibility of a myocardial injury degree and an immune cell infiltration rule of the model is realized, and suitability of the model and nano-drug research is enhanced; and a reliable tool is provided for research and development of targeted drugs such as immune cell membrane coated nanoparticles.

The invention discloses a medicinal and edible traditional Chinese medicine solid beverage for preventing and treating gout and reducing hypertension, hyperglycemia and hyperlipidemia, which comprises 25 medicinal and edible raw materials such as 20-30 parts of chrysanthemum, 15-20 parts of hawthorn and the like, preferably 25 g of chrysanthemum, 35 g of kudzuvine root and the like. The preparation method comprises the following steps: screening, washing, drying, processing by an ancient method, crushing, sieving by a 120-300-mesh sieve, mixing to prepare a material A, and processing into a bag or granular beverage. The beverage is free of toxic and side effects, free of saccharides and chemical additives, and capable of preventing and treating gout and'four highs', promoting excretion and metabolism of uric acid and enhancing immunity; the traditional Chinese medicine composition can soften heart and cerebral vessels, reduce carotid plaques, prevent thrombus and prevent cardiovascular and cerebrovascular diseases, has health-care and health-preserving effects, and is remarkable in curative effect through experimental verification.

Disclosed herein are compositions and methods for the modulation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) expression, wherein the compositions include an siRNA duplex or a conjugated siRNA duplex. Also disclosed herein are methods, and compositions for use in methods, of treating age-related macular degeneration (AMD) or hyperlipidemia. The compositions disclosed herein comprise an siRNA duplex that comprises a sense sequence and an antisense sequence, wherein the sense sequence and the antisense sequence are at least partially complementary to each other.

The application discloses a glucagon peptide-1 and glucagon receptor dual-agonistic polypeptide and application thereof, and the polypeptide structure is shown in the following general formula (I). The dual-agonistic polypeptide has dual-agonistic activity on human GLP-1 and glucagon receptors. The GLP-1 / glucagon receptor dual-agonistic polypeptide can effectively reduce blood sugar and weight, and has obvious lipid-regulating effect. The GLP-1 / glucagon receptor dual-agonistic polypeptide is stable in vivo, and is suitable to be used as an active component of drugs for diabetes, obesity, hyperlipidemia and the like.

The present invention discloses a golden chrysanthemum flavonoid glycoside derived from golden chrysanthemum, wherein the golden chrysanthemum flavonoid glycoside is apigenin 7-O-(6"-O-malonyl)-β-D-glucoside derived from golden chrysanthemum. The present invention separates and purifies apigenin 7-O-(6"-O-malonyl)-β-D-glucoside from golden chrysanthemum for the first time, completes the first synthesis through a 5-step synthesis process with a total yield of 2.7%, and discovers for the first time that the compound has activity in improving hyperlipidemia and fatty liver in vitro and in vivo. Therefore, the compound can be used in the preparation of products for treating related diseases such as hyperlipidemia and fatty liver.

The invention relates to a traditional Chinese medicine tea drink composition for treating obesity and hyperlipidemia. The composition is prepared from the following raw material medicines in parts by weight: 4-8 parts of roses, 4-8 parts of lotus leaves, 4-8 parts of pericarpium citri reticulatae, 8-12 parts of cassia seeds, 8-12 parts of raw hawthorn fruits, 8-12 parts of radix salviae miltiorrhizae and 2-6 parts of seville orange flowers. The invention further provides application of the traditional Chinese medicine tea drink composition. The whole formula integrates the functions of promoting digestion, removing food stagnation, promoting diuresis, activating blood, promoting the circulation of qi and relieving depression, treats both symptoms and root causes, is mild in nature, does not hurt healthy qi, and is suitable for people with phlegm-damp constitution, qi stagnation and blood stasis type obesity and hyperlipidemia to drink as tea.

This invention discloses a fermented traditional Chinese medicine for treating hyperlipidemia, its preparation method, and its application, relating to the field of traditional Chinese medicine. This fermented traditional Chinese medicine is prepared using Bacillus sp. JQ.Y-1, which was deposited on June 24, 2021, at the China Center for Type Culture Collection (CCTCC), Wuhan University, Wuhan, China, with accession number CCTCC NO: M2021761. The fermented traditional Chinese medicine provided by this invention offers a new alternative drug for the treatment of hyperlipidemia of the dampness-obstruction type in the middle jiao (middle burner). It has a significant lipid-lowering effect, is safe and reliable, can regulate intestinal flora, protect the liver and kidneys, and has no side effects.

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ANGPTL3 gene, as well as methods of inhibiting expression of ANGPTL3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsRNA compositions.

The invention discloses white paeony root polysaccharide with a blood fat reducing function as well as a preparation method and application of the white paeony root polysaccharide. The radix paeoniae alba polysaccharide with the blood fat reducing function is extracted from radix paeoniae alba for the first time, and cell experiments prove that the polysaccharide has the effect of reducing lipid generation in a high-fat cell model; further animal model experiments prove that the polysaccharide can also achieve the blood fat reducing effect in a hyperlipidemia animal model, it is proved that the polysaccharide can be used for preparing the blood fat reducing medicine, and the polysaccharide belongs to natural ingredients and is high in safety and wide in application prospect.

The invention provides antisense oligonucleotide aiming at a Sptbnl target spot and application of the antisense oligonucleotide. The antisense oligonucleotide can be used for knocking down the expression of Sptbnl, and in-vivo and in-vitro experiments find that the antisense oligonucleotide can be used for treating hyperlipidemia and NASH and can also be used for treating neovascular eye diseases.

The embodiment of the invention provides a traditional Chinese medicine preparation for improving three-high constitution and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials: 1-6 parts of fructus lycii, 2-10 parts of radix puerariae, 2-9 parts of fructus crataegi, 1-3 parts of rhizoma gastrodiae, 0.5-2 parts of radix notoginseng, 0.5-3 parts of radix salviae miltiorrhizae, 1-5 parts of flos chrysanthemi, 1-3 parts of pericarpium citri reticulatae, 2-9 parts of semen coicis, 1-3 parts of herba menthae, 1-5 parts of folium mori and 1-6 parts of flos lonicerae. Therefore, the medicinal and edible dual-purpose beverage with the effects of tonifying spleen and promoting the circulation of qi, clearing damp and burning fat, reducing phlegm and dredging collaterals, and promoting blood circulation to remove blood stasis is obtained, is a medicinal and edible and broad-spectrum product for preventing and improving physique, and is widely applicable to people with hyperlipidemia, hypertension, hyperglycemia and the like.

The present invention relates to a pharmaceutical composition which does not undergo rapid initial burst release of a drug by comprising sustained release microspheres consisting of texipatide or a pharmaceutically acceptable salt thereof, an initial burst release inhibitor, and a biodegradable polymer, has a high drug content with respect to particle size, and has high bioavailability, thus, the composition can minimize patient pain and inflammatory response that may occur when administered to a human body, and thus can be effectively used in the prevention or treatment of diabetes, beta cell dysfunction, hypertension, hyperlipidemia, obesity, and non-alcoholic steatohepatitis.

The invention relates to the technical field of functional food, in particular to a tartary buckwheat and roxburgh rose composition for regulating blood pressure and blood fat and a preparation method thereof. The tartary buckwheat and roxburgh rose composition comprises tartary buckwheat and roxburgh rose. The mass ratio of the tartary buckwheat to the roxburgh rose is 1: (1-3). In-vitro activity evaluation, cell experiments and animal experiments prove that flavonoid compounds of tartary buckwheat and active ingredients such as vitamin C of roxburgh rose in the composition generate a synergistic effect, so that the antioxidant capacity, the ACE inhibition rate, the cholesterol clearance rate and the pancreatic lipase inhibition rate can be remarkably improved, NO generation is effectively promoted, and the curative effect is good. The contents of TC, TG and LDL-L are reduced, the HDL-L level is increased, and the balance of vascular active substances is regulated. The raw materials are all medicinal and edible, are high in safety and free of side effects, provide a natural and efficient auxiliary conditioning scheme for chronic metabolic diseases such as hypertension and hyperlipidemia, and have a good industrialization prospect.

The invention provides application of ginkgo terpene lactones, bilobalide or stereoisomers thereof in preparation of drugs for preventing or treating hyperlipidemia and hyperlipidemia complications.

The present application belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating hyperlipidemia and application thereof. The traditional Chinese medicine composition provided by the present application comprises Pingshuqiu Sanqi, Xianye Jinquehua, Bai Mao Yinluomei, Xiannai Xuanfuhua, Laximu Ye, Baicaomu, Juemingzi, Zama Gen, Ezhangteng, Laogekuaopiao, resistance dextrin, black fungus, blueberry, Huangjing, Sangshen and Bohe. The traditional Chinese medicine composition for treating hyperlipidemia provided by the present application can reduce total cholesterol and triglyceride, reduce low-density lipoprotein, increase high-density lipoprotein level, and significantly inhibit cholesteryl esterase, lipase activity and inflammatory factors, and improve clinical symptoms of flying insect.

This invention discloses an octapeptide derived from soybean protein with the function of lowering blood pressure, blood sugar, and cholesterol, as well as its preparation and application, belonging to the field of small molecule peptide technology. The octapeptide sequence is YEGNWGPL, which can be obtained artificially or by targeted enzymatic hydrolysis of soybean protein isolate. Functional verification in a hyperlipidemia model shows that the octapeptide YEGNWGPL has the function of lowering blood lipids; functional verification in a hyperglycemia model shows that the octapeptide YEGNWGPL has the function of lowering blood sugar, with a significantly better effect than the drug metformin; functional verification in a hypertension model shows that the octapeptide YEGNWGPL has the function of lowering blood pressure, with a significantly better effect than the antihypertensive drug captopril; moreover, food-derived bioactive peptides have high biosafety, therefore, they can be applied to the development of related products for lowering blood pressure, blood sugar, and cholesterol or assisting in lowering blood pressure, blood sugar, and cholesterol, with good market prospects and application potential.

The invention discloses application of lactobacillus fermentum E1 in preparation of fat-reducing and weight-losing products, and belongs to the technical field of microorganisms. The lactobacillus fermentum E1 disclosed by the invention can remarkably promote fat metabolism in the zebra fish body in vivo, can remarkably reduce the content of triglyceride and total cholesterol in the hyperlipidemia zebra fish body, and has the potential of being applied to losing weight and regulating the blood fat level; theoretical reference and guidance basis are provided for developing probiotic preparations for treating or preventing obesity and hyperlipidemia by using the lactobacillus fermentum E1.

The invention relates to the technical field of electrolyzed water generators, in particular to a medical alkaline electrolyzed water generator based on blood fat regulation of hyperlipemia patients, which comprises a cathode tank and an anode tank, brackets are mounted at the bottom ends of the cathode tank and the anode tank, and an ion exchange tube is jointly mounted between the cathode tank and the anode tank; water inlet pipes are mounted at the bottom ends of the cathode tank and the anode tank. Concentration polarization of a water body to be electrolyzed can be reduced, the mass transfer efficiency of reactants and products in the electrolysis process is improved, accordingly, bubbles are prevented from being gathered on the surfaces of the first electrode bar and the second electrode bar, bubble separation can be accelerated by means of superposition of electrophoretic force generated by the electric field plate and the cavitation effect of the ultrasonic vibrators, and the electrolysis efficiency of the water body to be electrolyzed is improved. And ions can be promoted to diffuse to the surfaces of the first electrode bar and the second electrode bar, and large bubbles to be merged on the surfaces of the first electrode bar and the second electrode bar are scattered, so that the electrolysis efficiency and the electrolysis quality are effectively ensured, namely the production efficiency and the production quality of the alkaline electrolyzed water are effectively ensured.

The invention relates to the technical field of traditional Chinese medicines, in particular to a medicinal and edible traditional Chinese medicine formula GN-0613 decoction for reducing blood fat and a preparation method thereof, and the formula of the GN-0613 decoction comprises the following components in parts by weight: 10-30 parts of liquorice, 5-15 parts of ginseng, 3-10 parts of dried ginger, 10-20 parts of dandelion, 5-15 parts of momordica grosvenori, 10-20 parts of radix polygonati officinalis and 5-15 parts of Chinese dates. According to the decoction and the preparation method, a classic famous formula of the liquorice heart-fire purging decoction is improved into a full-medicine-food homologous formula to remove toxicity and improve the taste, and active ingredients are extracted to the maximum extent in combination with a modern preparation process, so that the decoction and the preparation method are used for safely and effectively treating the hyperlipemia.

The invention discloses application of knockout or inhibition of intestinal epithelium Ufbp1 gene expression in preparation of medicines for preventing and / or treating obesity, and belongs to the technical field of biological medicines. In order to solve the problems of limited effect, many side effects and the like of the existing obesity treatment means, the invention provides Ufbp1 specifically expressed by intestinal epithelial cells as a new anti-obesity intervention target for the first time. By knocking out or inhibiting intestinal epithelium Ufbp1, weight gain, adipose tissue accumulation, hyperlipidemia, liver fatty degeneration and insulin resistance induced by high fat diet can be effectively resisted. The action mechanism is related to influence on secretion of intestinal apolipoprotein ApoB48 / ApoA1 and further regulation and control of whole body lipid metabolism. The invention provides a clear target and theoretical basis for developing novel anti-obesity therapies such as small-molecule inhibitors and nucleic acid drugs of targeted intestinal epithelium Ufbp1, and has important clinical transformation prospects.

The invention provides a traditional Chinese medicine composition which comprises the following components in parts by weight: 32-34 parts of rumex hanus, 20-31 parts of dandelion, 20-32 parts of uncaria rhynchophylla and 15-35 parts of gastrodia elata. And at least one of the following six traditional Chinese medicines in parts by weight: 17-37 parts of radix paeoniae alba, 15-20 parts of lumbricus, 10-45 parts of eucommia ulmoides, 22-34 parts of longan seeds, 20-37 parts of tribulus terrestris and 10-30 parts of herba siegesbeckiae. The traditional Chinese medicine composition is taken by adopting deuterium-depleted water. The combination of the traditional Chinese medicinal materials has a synergistic effect in the aspects of treating hypertension, hyperlipidemia and metabolic syndrome, the traditional Chinese medicinal materials respectively contain different active ingredients, the overall curative effect is enhanced by regulating blood pressure, blood fat and metabolic functions through multiple targets, and in order to enable the traditional Chinese medicinal composition to better exert the drug effect, the traditional Chinese medicinal composition has a remarkable curative effect. Preferably, the deuterium-depleted water is matched with the traditional Chinese medicine composition to be taken, and the effect of the deuterium-depleted water is developed by 1-2 times.

The present application relates to a new use of Fuling Gancao Decoction, and specifically discloses application of Fuling Gancao Decoction in treatment of hyperlipidemia, wherein the Fuling Gancao Decoction is composed of the following components in parts by weight: Fuling 2 parts, Guizhi 2 parts, Zhigancao 1 part and Shengjiang 3 parts. It is found through animal experiment research that the Fuling Gancao Decoction can improve the symptoms of hyperlipidemia rats, reduce the content of TG, TC and LDL-C in serum, improve the liver lipid, blood sugar of hyperlipidemia model animals, reduce the liver coefficient, improve the liver cell fatty degeneration, reverse the pathological morphology of adipose tissue cells and the mitochondrial damage of hyperlipidemia model animals. A new indication of the Fuling Gancao Decoction is found, the development of traditional Chinese medicines is promoted, and a new drug composition with less side effects is provided for treatment of hyperlipidemia.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a traditional Chinese medicine composition for athletes and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises 4 parts of ginseng, 8 parts of polygala tenuifolia, 20 parts of Chinese yam, 12 parts of bighead atractylodes rhizome, 4 parts of pseudo-ginseng, 15 parts of rhizoma polygonati, 12 parts of flax seed, 10 parts of wolfberry, 15 parts of radix ophiopogonis, 15 parts of prepared rehmannia root, 15 parts of prepared fleece flower root, 15 parts of longan aril, 10 parts of mulberry leaf, 12 parts of wild chrysanthemum flower, 10 parts of eucommia ulmoides, 12 parts of rhizoma cibotii, 12 parts of cortex acanthopanacis and 12 parts of radix achyranthis bidentatae. According to the traditional Chinese medicine composition for the athletes and the preparation method of the traditional Chinese medicine composition, the composition of a decoction formula and a beverage formula can help the athletes to accelerate elimination of exercise-induced fatigue, improve mental functions and enhance physique, physical strength, intelligence and memory; the composition of the weight-losing formula definitely provides a conditioning scheme for hyperlipemia obesity, obesity due to spleen deficiency and obesity due to qi deficiency.

Provided are a traditional Chinese medicine composition for lipid reduction, a preparation method therefor, and use thereof. The traditional Chinese medicine composition comprises a lipid-reducing core component and auxiliary components. The lipid-reducing core component is composed of Mallotus oblongifolius and Dalbergiae Odoriferae Lignum, and the auxiliary components comprise Crataegi fructus and Salviae miltiorrhizae. The traditional Chinese medicine composition can ameliorate the hyperlipidemia condition and reduce the body weight of model animals, and can also reduce the expression of various inflammatory factors.