51 results about "Piperine" patented technology

The invention relates to a Kava pepper root extract with soothing, repairing and anti-wrinkle effects as well as a preparation method and application thereof, and belongs to the technical field of biological medicines and cosmetics. According to the method, hydroxypropyl-cyclodextrin and / or sulfobutyl-cyclodextrin are / is used as an extracting agent to fully extract the main functional component kavain in the kava pepper root powder, and a fat-soluble component kavain is clathrated by using the hydrophilicity and clathration effect of hydroxypropyl-cyclodextrin and sulfobutyl-cyclodextrin, so that the extraction efficiency of kavain is improved, and the yield of kavain is increased. The extract which contains the kavain and is soluble in water is obtained. The mixture of polyaluminum chloride and diatomite is used as an impurity removal agent to fully remove unstable components and pigments in the crude extract, and the prepared kavain extract has high purity and extraction rate, and has good solubility in water and good stability. The kava pepper root extract and the centella asiatica extract are combined to achieve a synergistic repairing effect, and the composition can be widely applied to the industries of biological medicine, cosmetics and the like.

The invention belongs to the field of preparation of medicaments for reducing uric acid, and particularly relates to a traditional Chinese medicine composition for reducing uric acid level and a preparation method thereof. Piperine, oat beta-glucan and medium chain triglyceride are mixed to react, a carrier material with a net structure is formed, a uric acid reducing solution obtained through adsorption and fermentation is freeze-dried, and the obtained efficient uric acid reducing component can remarkably and efficiently reduce the uric acid level in an organism; the regulating component is mixed with the metabolism promoting component obtained after powdering, the mixture is put into the coating material which can form a transparent film after being dried, and freeze spray drying is performed to obtain the long-acting agent which can stably play a role in a long-acting manner; the composition for maintaining stability and improving taste is uniformly sprayed on the surface of the traditional Chinese medicine component for reducing the uric acid level, and the prepared traditional Chinese medicine composition for reducing the uric acid level is remarkable and efficient in effect, improved in taste, free of peculiar smell, beneficial to persistent taking and free of irritation to liver and kidney after being taken for a long time.

The invention aims to provide a method for determining the content of main effective components of Xiaoyianmi cream and an application of the method, and aims to solve the technical problem that a Xiaoyianmi cream compound preparation is lack of efficient and accurate multi-component synchronous quality evaluation due to complex components of the Xiaoyianmi cream compound preparation. According to the method, a chromatography-tandem mass spectrometry technology is adopted, chromatography and mass spectrometry conditions are optimized, and an analysis method for simultaneously determining six components such as phloridine, piperlonguminine, piperine, N-trans-feruloyltyramine, DL-B-phenyllactic acid and pinocembrin is established. The determination method provided by the invention has the advantages of being simple and convenient to operate, high in sensitivity, good in repeatability, high in accuracy and the like, can realize rapid and synchronous determination of multi-index components in the Xiaoyi honey paste, and provides reliable technical support for quality control and standardization of the Xiaoyi honey paste.

This invention discloses a method for preparing piperine starch microcapsules with sustained-release properties, belonging to the field of food processing technology. Using piperine as the core material, oleic acid as the oil phase carrier, and PG 2000 type octenyl succinate starch ester as the wall material, sustained-release piperine microcapsules are prepared through oil phase preparation, aqueous phase preparation, high-speed shearing, high-pressure homogenization, and spray drying. The microcapsules prepared by this invention have high encapsulation efficiency, small and uniformly distributed reconstituted particle size, and a stable system that is not prone to sedimentation. This allows for the slow and continuous release of piperine in simulated gastrointestinal fluid, significantly improving its poor water solubility, low stability, and low bioavailability. The resulting product can be widely used in the food, health product, and pharmaceutical fields.

The application provides a dual-target piperine compound used as an alpha-glucosidase inhibitor and an aldose reductase inhibitor, the compound has a general structure of piperine, a series of structural modifications are carried out based on piperine, and finally a series of dual-target piperine compounds are synthesized. The dual-target piperine compound provided by the application can simultaneously inhibit the activities of alpha-glucosidase and aldose reductase, has the function of dual targets, can be used as a new alpha-glucosidase inhibitor and aldose reductase inhibitor, and is used as an anti-diabetic drug or for preparing an anti-diabetic drug.

Particle structure of a nutrient composition for reducing colonization by Helicobacter pylori, reducing inflammation of the gastric mucosa and promoting the repair of the esophageal barrier, comprising a core layer, a binder layer and an antioxidant layer, wherein the core layer contains a chocolate paprika extract and piperine, the binder layer consists of a honey complex and envelops the core layer so that the structure of the core layer is stabilized, the honey complex is formed by mixing honey and turmeric extract powder and the antioxidant layer contains sea buckthorn powder and envelops the binder layer.

The present application relates to the field of feed additive, and discloses a feed additive, a preparation method and application thereof.The feed additive contains astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and a carrier.The preparation method comprises the following steps: mixing astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and the carrier.The feed additive can significantly improve the stress resistance, immunity, antioxidant capacity and disease resistance of aquatic animals, and has significant economic benefits.

A composition for relieving hangovers and protecting the liver, made from the following raw materials in the indicated weight ratios: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, and 1-25 parts of honey or oligosaccharides.

The present invention relates to a culture medium composition for in vitro maturation of oocytes, comprising piperine as an active ingredient, and an in vitro embryo production method using same. The culture medium composition for in vitro maturation of oocytes, comprising piperine as an active ingredient, of the present invention, can qualitatively improve oocytes by inhibiting reactive oxygen species, and in vitro embryo production efficiency can be increased using in vitro matured oocytes obtained from the medium of the present invention.

The invention relates to an alkaloid liposome, a preparation process thereof and an application of the alkaloid liposome in an external preparation, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology which is higher in stability, safe and non-irritating. According to the scheme, the alkaloid liposome technology is characterized in that raw materials comprise alkaloid, hydrogenated lecithin, grease, polyhydric alcohols and water; the alkaloid is selected from at least three of piperine, tetrahydropiperine, tetrahydropalmatine, dihydrooat alkaloid D, caffeine and leonurine; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON80H or PhoslipTM HPC (Hydroxyethyl Propyl Phosphatidylcholine). The liposome is good in stability and low in irritation, and has the effects of promoting local tissue microcirculation, reducing choked flow rate, increasing local body temperature, enhancing tissue metabolism and improving local inflammation when being externally applied to skin.

The invention relates to a flavor beverage capable of improving sleep and a preparation method thereof. Every 50ml of the flavored beverage comprises the following raw materials: a functional agent, a sweetening agent, an acidulant, a stabilizing agent and a solvent, the functional agent is prepared from 100 to 150 mg of gamma-aminobutyric acid, 2.5 to 3.5 g of resistant dextrin, 8 to 12 mg of long pepper extract powder, 6 to 10 mg of ginger extract powder, 12 to 18 mg of EGCG, 0.6 to 1.0 mg of L-phenylalanine compound, 3.0 to 4.5 mg of vitamin B6 and 1.5 to 2.25 mg of vitamin B2; the sweetening agent is prepared from 2.0 to 3.0 g of high fructose corn syrup, 0.4 to 0.6 g of fructose, 2.5 to 3.5 mg of acesulfame potassium and 1.2 to 1.8 mg of aspartame; the sour agent is prepared from 25 to 35 mg of vitamin C, 20 to 30 mg of citric acid and 3 to 5 ml of natural flavor extracting solution; the stabilizing agent is prepared from 5.0 to 7.0 mg of xanthan gum and 4.0 to 6.0 mg of glycerin monostearate; the solvent is purified water, and the total volume is 50ml; wherein the purity of the gamma-aminobutyric acid is greater than or equal to 99%, the piperine content in the long pepper extract powder is greater than or equal to 5%, and the gingerol content in the ginger extract powder is greater than or equal to 1%. The flavor beverage capable of improving sleep provided by the invention can mildly help sleep, and is high in bioavailability, healthy in taste, strong in stability, free of melatonin dependence and easy in mass production.

This invention discloses an ergothioneine-curcumin synergistic anti-inflammatory and anti-aging composite composition and its preparation method, relating to the fields of biomedicine and functional skincare technology. This invention constructs a ternary nanolipid carrier core-shell hierarchical structure consisting of a hydrophobic core, an interface-enhancing layer, and a hydrophilic shell. The hydrophobic core, formed by hydrogenated lecithin and phytosterols, provides a stable lipid microenvironment for curcumin. The oil-water interface region of the lipid bilayer utilizes its polar gradient to directionally anchor piperine molecules from black pepper extract, allowing piperine to be precisely positioned at the lipid membrane interface. The hydrophilic shell, composed of thiolated hyaluronic acid, covalently connects ergothioneine via thiol-disulfide bonds, stably fixing ergothioneine to the carrier surface. This allows it to exert its antioxidant protective effect upon contact with the skin or mucous membranes, while simultaneously preventing the migration and diffusion of ergothioneine into the inner lipid region. This achieves spatially ordered partitioning and functional synergy of the three active ingredients.

The invention provides a traditional Chinese medicine active ingredient composition for improving migraine through nasal administration. The traditional Chinese medicine active ingredient composition comprises the following traditional Chinese medicine active ingredients: tetrahydrojateorhizine, scopoletin, ferulic acid, isoferulic acid, piperlongumine and piperine. The invention also provides application of the traditional Chinese medicine active ingredient composition, and the traditional Chinese medicine active ingredient composition is used for preparing medicines for improving migraine through nasal administration. The traditional Chinese medicine active component composition can significantly inhibit LPS-induced BV2 nerve cell inflammation, and can be used for preparing drugs for improving migraine through nasal administration.

The invention relates to the technical field of combination of functional food and traditional Chinese medicine, and particularly discloses a beverage with a function of relieving muscular soreness after exercise and a preparation method thereof, the beverage comprises a white peony root extract, a honey-fried licorice root extract, a turmeric extract and a black pepper extract; the content of glycyrrhizic acid in the honey-fried licorice root extract is lower than 0.1%, and the content of piperine in the black pepper extract is not lower than 98%, and preparing and weighing the white peony root extract, the honey-fried licorice root extract, the turmeric extract and the black pepper extract; mixing with electrolyte and erythritol, and adding purified water to a constant volume to obtain a mixed solution; the mixed liquid is stirred and homogenized, and homogenized liquid is obtained; and performing sterilization treatment on the homogenized liquid, and then performing sterile filling to obtain the beverage. By forming a three-in-one synergistic scheme of spasmolysis, anti-inflammation and synergy, the invention provides the drink for recovering after exercise, which is safe and effective and has an easily accepted taste.

This invention relates to the field of food processing technology and discloses a method for improving the stability and bioavailability of astaxanthin by combining piperine with a whey protein fibrillary-algin complex. The method specifically includes the following steps: S1. Preparation of whey protein fibrillary; S2. Loading piperine onto whey protein fibrillary; S3. Complexation of piperine-loaded whey protein fibrillary with sodium alginate; S4. Preparation of an astaxanthin-piperine co-encapsulated emulsion. This invention constructs a three-dimensional network resistant to pepsin hydrolysis through electrostatic complexation; enhances the effective concentration of piperine in the intestine through co-encapsulation, efficiently regulating the expression of P-gp efflux transport proteins and the transmembrane absorption of astaxanthin; and utilizes the functional property of piperine to inhibit the activity of P-gp efflux transport proteins to achieve efficient absorption of astaxanthin.

The invention relates to the technical field of functional food, and discloses a traditional Chinese medicine for treating kidney deficiency and a preparation method of the traditional Chinese medicine. 250 to 350 parts of radix astragali seu hedysari; 120 to 180 parts of coix seeds; 80 to 130 parts of chicken's gizzard-membrane; 100 to 160 parts of phaseolus calcaratus; 40-60 parts of black ginger; 180 to 250 parts of L-arginine; 150 to 200 parts of polyvinylpyrrolidone K30; 1 to 3 parts of piperine; 4 to 6 parts of zinc gluconate; 200-250 parts of fried glutinous rice flour; and 100 to 150 parts of isomaltitol. Through synergistic compatibility, solid dispersion and targeted extraction technologies, the bioavailability and stability of active ingredients are improved, and a better synergistic effect is achieved.

The invention provides composite particles for regulating and controlling bioavailability and tissue distribution of resveratrol and piperine and a preparation method of the composite particles, and belongs to the technical field of nutritional active ingredient delivery systems. According to the resveratrol-zein-lecithin-piperine-konjac glucomannan composite particle and the preparation method thereof, firstly, a particle core is formed through an anti-solvent coprecipitation method, then a piperine solution and a konjac glucomannan solution are sequentially injected, and the resveratrol-zein-lecithin-piperine-konjac glucomannan composite particle of a core-shell structure is formed through layer-by-layer assembly. Compared with a free form, the composite particle has the advantages that the physical and chemical stability of the resveratrol and the piperine is remarkably improved, the residence time of the resveratrol and the piperine in intestinal tracts is prolonged, and the oral bioavailability and the liver tissue enrichment capacity of the resveratrol and the piperine are effectively enhanced. The composite particle provided by the invention is clear in structure, the preparation method is simple and convenient to operate, and the composite particle has a good application prospect in functional food and drug development.

This invention relates to novel feed additive compositions for use as preventative and therapeutic agents for fungal, viral, and bacterial infections in humans, animals, and aquatic animals, including white spot shrimp virus (WSSV) infection in aquatic species (including crabs and shrimp). The additive composition comprises glyceryl monolaurate, rosemary oil, nisin, calcium carbonate, piperine, sodium alginate, and carboxymethyl cellulose, and further comprises glyceryl monolaurate and a saponin-rich extract in proportions described herein. The additive composition can be used at lower concentrations for the prevention of WSSV infection in aquaculture species and at higher concentrations for the treatment of WSSV infection in aquaculture species. This invention also relates to a method for manufacturing the additive composition described above.

The application provides a method for extracting piperine in piper longum, comprising the following steps: defatting the crushed piper longum to obtain defatted piper longum powder, mixing the defatted piper longum powder with a ternary eutectic solvent, performing ultrasonic extraction, filtering and centrifuging to obtain supernatant, performing multiple extraction on the supernatant, combining the extraction liquid to obtain a piperine extraction liquid, wherein the ternary eutectic solvent comprises choline chloride-lactic acid-ethylene glycol or choline chloride-lactic acid-1,2-propanediol. The application combines the optimal eutectic solvent system screened out with the ultrasonic extraction technology, and the extraction rate of piperine in piper longum is measured to be as high as 9.42%, which provides a new idea for efficient extraction of piperine in piper longum and high-value conversion of piper longum resources.

A composition for improving female health, sexual performance, and benefiting the gut-brain axis is disclosed. The composition includes sufficient amounts of Black Cohosh Extract 20:1, Black Pepper Pepper Extract (95% piperine), Korean Red Ginseng 8:1, Ginkgo Biloba Leaf 8:1, Horny Goat Weed Extract 8:1, Tribulis Terrestris vine 8:1, Avena Sativa Extract Seed 8:1, Pine Bark Extract 8:1, Muira Pauma Extract 8:1, Lemon Balm P.E. 4:1 (Melissa officinalis folium), Red Raspberry Leaf Extract 4:1, Damiana Leaf Extract 4:1, Butea Superba Root 8:1, Ashwagandha Extract 4:1, L-Arginine HCL Powder, L-Citrulline, a Probiotic Blend, TKA 200, Fermented Green Tea Extract with L-Theanine and Caffeine, Folic Acid, Zinc Aspartate, Vitamin E (D-alpha Tocopheryl Acetate), Vitamin D3, Vitamin C (Ascorbic Acid), Vitamin B12 (Methyl cobalamin), Vitamin B6 (Pyridoxine HCL), Pantothenic Acid (D-Calcium Pantothenate), Vitamin B3 Crystalline Powder (Niacinamide), Vitamin B2 Powder (Riboflavin), Biotin (D-biotin), Vitamin B1 HCl (Thiamine HCL).

The application belongs to the technical field of traditional Chinese medicines, and particularly relates to a composition for treating non-alcoholic fatty liver, a pharmaceutical preparation and a preparation method and application thereof. The application provides a composition DJZ-x for treating non-alcoholic fatty liver, which is composed of ginsenoside Rg1, 6-gingerol and / or hydroxyl-alpha-piperine in a specific proportion, and the components have a synergistic effect. The composition has clear components, stable and controllable quality, and a lower effective dose, and can replace traditional large Jianzhong decoction, and has a good application prospect in treating non-alcoholic fatty liver disease (NAFLD).

The invention relates to the technical field of medicine, in particular to a vagina tightening bacteriostatic preparation and a preparation method thereof.The vagina tightening bacteriostatic preparation is prepared from, by mass, 0%-0.5% of carbomer, 5%-13% of galactomannan, 1%-6% of transient pink regulator, 0.1% of tetrahydropiperine, 4% of physalis alkekengi extracting solution and 10% of composite plant fungicide; the amount of the neutralizer is the amount which enables the pH value of the preparation to be 6.0-6.5. According to the invention, the galactomannan instantly forms a film to tighten and shrink vagina, the instant plicatin rapidly thickens vagina mucosa, the plant penetrant tetrahydropiperine promotes permeation of effective components and increases the mucosa absorbance of the effective components, so that the vagina shrinking effect is multiplied, and the plant penetrant tetrahydropiperine cooperates with other various components to achieve a synergistic effect, so that the vagina shrinking effect is improved. And a rapid and efficient vagina contracting effect is achieved.

The invention discloses a nano ultramicro liquid DHA composition and a preparation method thereof, and belongs to the technical field of functional foods. The composition is prepared from the following raw materials: DHA algae oil, phosphatidylserine, walnut peptide, cerebroprotein peptide, curcumin, piperine, a herba cistanche extract, a hericium erinaceus extract, vitamin B6, vitamin B12, magnesium citrate, maltitol liquid, concentrated apple clear juice, yellow lemon concentrated liquid, green lemon concentrated juice, sodium citrate, edible essence, polyglycerol fatty acid ester and soybean powder phospholipid. Sodium ascorbate, glycerol and water; the preparation method comprises the following steps: (1) weighing raw materials; (2) premixing the component 1; (3) premixing a component 2; (4) pre-dissolving the component 3; (5) preparing a coarse emulsion; (6) performing superfine emulsification; (7) blending and mixing; (8) homogenizing and emulsifying; (9) filling and sealing; and (10) sterilizing. The composition is suitable for heart and intelligence nutrition supplement of children and special crowds, and has good taste, physical stability and oral absorption performance.

The present invention discloses an NMN composite anti-aging formulation for activating the SIRT1 pathway and a preparation thereof, relating to the technical field of pharmaceutical preparations. The formulation consists of active ingredients and pharmaceutically acceptable excipients. The active ingredients comprise β-nicotinamide mononucleotide, trans-resveratrol, quercetin, piperine, and trimethylglycine in specified weight ratios. The formulation forms a synergistic system targeting the SIRT1 pathway through a biphasic design enabling time-sequential release of components. The invention improves the solubility, stability, and bioavailability of active ingredients, and addresses asynchronous release and poor absorption of poorly soluble components in conventional formulations. The preparation process is compatible with conventional pharmaceutical equipment and ensures consistent batch quality.

The present invention discloses an ergothioneine-curcumin synergistic anti-inflammatory and anti-aging complex composition and a preparation method thereof, relating to biomedicine and functional skincare products. A ternary nanolipid carrier core-shell structure is constructed, comprising a hydrophobic core, an interface enhancement layer, and a hydrophilic shell. The hydrophobic core formed by hydrogenated lecithin and phytosterol provides a stable lipid microenvironment for curcumin. Piperine from black pepper extract is directionally anchored at the oil-water interface region of the lipid bilayer, enabling precise interfacial localization. The hydrophilic shell composed of thiolated hyaluronic acid covalently links ergothioneine through thiol-disulfide bonds, stably fixing it on the carrier surface. This enables ergothioneine to provide immediate antioxidant protection upon contact with skin or mucous membranes while preventing migration into the lipid core, thereby achieving spatial partitioning and synergistic functionality of the three active ingredients.

A cyclocurcumin-based composition comprising: cyclocurcumin in an amount of 25 to 40% by weight of the total composition; one or more residual curcuminoids, including curcumin and demethoxycurcumin, in a total amount of 8 to 18% by weight; an antioxidant stabilizer selected from ascorbic acid, tocopherol, or a combination thereof in an amount of 3 to 8% by weight; a bioavailability enhancer containing piperine in an amount of 1 to 3% by weight; and a pharmaceutically acceptable excipient in an amount of 40 to 60% by weight.

The application discloses an NMN compound anti-aging preparation for activating a SIRT1 channel and a preparation method thereof, relates to the technical field of pharmaceutical preparations, and discloses the preparation which is composed of active ingredients and pharmaceutically acceptable adjuvants, wherein the active ingredients account for 100 parts in total in terms of weight fraction and include the following components: 30-60 parts of beta-nicotinamide mononucleotide; 8-20 parts of trans-resveratrol; 2-10 parts of quercetin; 0.5-3 parts of piperine; and the rest is trimethylglycine. The application forms a synergistic regulation system targeting the SIRT1 channel by compounding five active ingredients, combines with a time sequence synergistic release dual-phase preparation design and adjuvant collocation, realizes continuous and efficient activation of the channel, solves the problems of asynchronous release of components in traditional preparations, poor absorption of poorly soluble components, improves the bioavailability of components and the storage stability of the preparation, reduces the metabolic burden of the body, and the preparation process is suitable for conventional pharmaceutical equipment, so that the quality consistency between batches can be ensured.

The invention discloses a synergistic interaction type nano-emulsion for promoting protein absorption and application of the nano-emulsion to improvement of skeletal muscle health, and particularly provides a nano-emulsion which comprises piperine, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate, sodium hyaluronate and sodium hyaluronate. Whey protein; the grease contains vegetable oil; and water. In the embodiment of the invention, the piperine increases the absorption of the whey protein digestive peptide in the cell bypass pathway of the small intestine by opening the close connection of the intestinal tract, meanwhile, a nano-emulsion system with a similar protein crown structure is constructed, and the nano-emulsion effectively improves the bioavailability of the piperine and the whey protein. Furthermore, the piperine and the whey protein play a synergistic effect, so that the transfer and utilization of free amino acids in blood to muscle tissues are promoted, and the synthesis of skeletal muscle proteins is enhanced. Compared with a composition formed by directly mixing single whey protein powder and free piperine with whey protein, the nano-embedding technology provided by the invention has better effects in the aspects of improving the motor function and intervening sarcopenia, and has extremely high application value.

The application discloses an alkaloid liposome and a preparation process and application thereof in external preparations, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology with higher stability and safety and no irritation. The scheme points are that raw materials include alkaloids, hydrogenated lecithin, oil, polyhydric alcohol and water; the alkaloids are selected from at least three kinds of piperine, tetrahydropiperine, fumarine, dihydroavenanthramide D, caffeine and leonuride; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON 80H or Phoslip HPC. The liposome has good stability and low irritation, and has the effects of promoting local tissue microcirculation, reducing resistance, improving local inflammation, improving local body temperature, enhancing tissue metabolism and the like when being used externally on the skin.