90 results about "Piperine" patented technology

The invention relates to a Kava pepper root extract with soothing, repairing and anti-wrinkle effects as well as a preparation method and application thereof, and belongs to the technical field of biological medicines and cosmetics. According to the method, hydroxypropyl-cyclodextrin and / or sulfobutyl-cyclodextrin are / is used as an extracting agent to fully extract the main functional component kavain in the kava pepper root powder, and a fat-soluble component kavain is clathrated by using the hydrophilicity and clathration effect of hydroxypropyl-cyclodextrin and sulfobutyl-cyclodextrin, so that the extraction efficiency of kavain is improved, and the yield of kavain is increased. The extract which contains the kavain and is soluble in water is obtained. The mixture of polyaluminum chloride and diatomite is used as an impurity removal agent to fully remove unstable components and pigments in the crude extract, and the prepared kavain extract has high purity and extraction rate, and has good solubility in water and good stability. The kava pepper root extract and the centella asiatica extract are combined to achieve a synergistic repairing effect, and the composition can be widely applied to the industries of biological medicine, cosmetics and the like.

The invention belongs to the field of preparation of medicaments for reducing uric acid, and particularly relates to a traditional Chinese medicine composition for reducing uric acid level and a preparation method thereof. Piperine, oat beta-glucan and medium chain triglyceride are mixed to react, a carrier material with a net structure is formed, a uric acid reducing solution obtained through adsorption and fermentation is freeze-dried, and the obtained efficient uric acid reducing component can remarkably and efficiently reduce the uric acid level in an organism; the regulating component is mixed with the metabolism promoting component obtained after powdering, the mixture is put into the coating material which can form a transparent film after being dried, and freeze spray drying is performed to obtain the long-acting agent which can stably play a role in a long-acting manner; the composition for maintaining stability and improving taste is uniformly sprayed on the surface of the traditional Chinese medicine component for reducing the uric acid level, and the prepared traditional Chinese medicine composition for reducing the uric acid level is remarkable and efficient in effect, improved in taste, free of peculiar smell, beneficial to persistent taking and free of irritation to liver and kidney after being taken for a long time.

The invention belongs to the technical field of biological medicines, and discloses a fish collagen and rose double-effect anti-aging composition, and the core active ingredients of the fish collagen and rose double-effect anti-aging composition comprise fish collagen peptide, red roses with double petals, dried cranberries, Chinese wolfberry fruits, roxburgh rose puree and saffron. According to the preparation method, specific degradation of intestinal flora is realized by virtue of the targeting effect of the xylooligosaccharide on bifidobacteria through the compound polysaccharide microcapsules, so that collagen peptide and antioxidant components are accurately released in colon, gastric acid damage is effectively avoided, and meanwhile, the piperine nanoparticles inhibit the activity of UGT enzyme, so that the anti-oxidation effect of the collagen peptide on the colon is improved, and the anti-oxidation effect of the collagen peptide on the colon is improved. The bioavailability of crocin is increased to 45% or above from 2%, the absorption rate of rose polyphenol is increased by 3 times, the intestinal absorption efficiency of collagen peptide reaches 95%, a remarkable breakthrough is achieved compared with 60-80% of a traditional process, and an efficient delivery mode of targeted release-absorption enhancement is constructed.

The invention aims to provide a method for determining the content of main effective components of Xiaoyianmi cream and an application of the method, and aims to solve the technical problem that a Xiaoyianmi cream compound preparation is lack of efficient and accurate multi-component synchronous quality evaluation due to complex components of the Xiaoyianmi cream compound preparation. According to the method, a chromatography-tandem mass spectrometry technology is adopted, chromatography and mass spectrometry conditions are optimized, and an analysis method for simultaneously determining six components such as phloridine, piperlonguminine, piperine, N-trans-feruloyltyramine, DL-B-phenyllactic acid and pinocembrin is established. The determination method provided by the invention has the advantages of being simple and convenient to operate, high in sensitivity, good in repeatability, high in accuracy and the like, can realize rapid and synchronous determination of multi-index components in the Xiaoyi honey paste, and provides reliable technical support for quality control and standardization of the Xiaoyi honey paste.

This invention discloses a method for preparing piperine starch microcapsules with sustained-release properties, belonging to the field of food processing technology. Using piperine as the core material, oleic acid as the oil phase carrier, and PG 2000 type octenyl succinate starch ester as the wall material, sustained-release piperine microcapsules are prepared through oil phase preparation, aqueous phase preparation, high-speed shearing, high-pressure homogenization, and spray drying. The microcapsules prepared by this invention have high encapsulation efficiency, small and uniformly distributed reconstituted particle size, and a stable system that is not prone to sedimentation. This allows for the slow and continuous release of piperine in simulated gastrointestinal fluid, significantly improving its poor water solubility, low stability, and low bioavailability. The resulting product can be widely used in the food, health product, and pharmaceutical fields.

The application provides a dual-target piperine compound used as an alpha-glucosidase inhibitor and an aldose reductase inhibitor, the compound has a general structure of piperine, a series of structural modifications are carried out based on piperine, and finally a series of dual-target piperine compounds are synthesized. The dual-target piperine compound provided by the application can simultaneously inhibit the activities of alpha-glucosidase and aldose reductase, has the function of dual targets, can be used as a new alpha-glucosidase inhibitor and aldose reductase inhibitor, and is used as an anti-diabetic drug or for preparing an anti-diabetic drug.

Particle structure of a nutrient composition for reducing colonization by Helicobacter pylori, reducing inflammation of the gastric mucosa and promoting the repair of the esophageal barrier, comprising a core layer, a binder layer and an antioxidant layer, wherein the core layer contains a chocolate paprika extract and piperine, the binder layer consists of a honey complex and envelops the core layer so that the structure of the core layer is stabilized, the honey complex is formed by mixing honey and turmeric extract powder and the antioxidant layer contains sea buckthorn powder and envelops the binder layer.

The present invention discloses the use of piperine or its derivatives, relating to the field of pharmaceutical technology. The present invention utilizes natural piperine as a precursor compound and chemically modifies it to obtain a series of novel piperine derivatives. Pharmacodynamic evaluations in leukemia, ovarian cancer, and pancreatic cancer cell models in vitro and in vivo revealed that several novel piperine derivatives inhibit tumor cell proliferation, induce tumor cell apoptosis, and promote leukemia cell differentiation. The present invention provides a group of compounds with novel structures. The synthetic route employed utilizes green chemistry reactions, making them more environmentally friendly and more economical in terms of raw materials. These compounds can be used to develop new drugs for the treatment of leukemia, ovarian cancer, and pancreatic cancer.

The invention discloses a processing method of fructus piperis longi. The processing method comprises the following steps: pretreating fresh fructus piperis longi; mixing fructus piperis longi powder and butter according to a mass ratio of 10: (0.5-3), stir-frying, cooling to room temperature after stir-frying, and taking out; according to the method, fructus piperis longi powder is fried with butter, so that the toxicity of fructus piperis longi is reduced, and the medication safety is ensured to the greatest extent; active ingredients (such as piperine) in the fructus piperis longi are fat-soluble, so that the bioavailability of the fructus piperis longi can be improved by co-frying the fructus piperis longi and the butter, and the absorption of a human body on the effective ingredients of the fructus piperis longi

The present application relates to the field of feed additive, and discloses a feed additive, a preparation method and application thereof.The feed additive contains astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and a carrier.The preparation method comprises the following steps: mixing astaxanthin, curcumin, vitamin C palmitate, vitamin E, vitamin D3, piperine and the carrier.The feed additive can significantly improve the stress resistance, immunity, antioxidant capacity and disease resistance of aquatic animals, and has significant economic benefits.

A composition for relieving hangovers and protecting the liver, made from the following raw materials in the indicated weight ratios: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, and 1-25 parts of honey or oligosaccharides.

The invention relates to a preparation method of boiled wine, which is characterized in that red wine is used as base wine, auxiliary materials such as dried orange peel, white pepper, dried shredded ginger, haw slices and xylitol are added, and the boiling is completed through a multi-step preparation process. The method comprises the steps of pre-frying, braising, pre-cooking, high-pressure braising, secondary cooking, low-temperature seasoning cooking and the like, and it is ensured that aromatic substances in the auxiliary materials are fully released. Compared with a traditional boiling technology, coumarin and citrus aldehyde in the dried orange peel and gingerol in the dried ginger shreds can be reserved in the stir-frying and braising processes, so that part of piperine in the white pepper is volatilized, and the spicy feeling is reduced; high-pressure braising and natural cooling prevent aromatic substances from volatilizing along with steam. In addition, secondary cooking can promote the conversion of gingerol to zingerone, so that the cooked grape wine is more sweet and warm in mouth feel, and the quality and flavor of the finished product are improved.

The present invention relates to a culture medium composition for in vitro maturation of oocytes, comprising piperine as an active ingredient, and an in vitro embryo production method using same. The culture medium composition for in vitro maturation of oocytes, comprising piperine as an active ingredient, of the present invention, can qualitatively improve oocytes by inhibiting reactive oxygen species, and in vitro embryo production efficiency can be increased using in vitro matured oocytes obtained from the medium of the present invention.

The invention discloses a method for regulating fatty acid metabolism by utilizing condiments to strengthen anaerobic digestion of kitchen waste to produce marsh gas, and relates to the field of kitchen waste treatment.The method comprises the following steps that piperine condiments in the kitchen waste are recognized and utilized, residual sludge is added into the kitchen waste containing piperine, the mixture is mixed to be uniform, and the marsh gas is obtained; controlling the concentration of piperine in the mixed material within a certain range interval, and adjusting the pH value; and feeding the treated mixed material into an anaerobic digestion reactor, and monitoring the biogas yield and the daily gas yield, so as to realize the enhancement of biogas production by anaerobic digestion of the kitchen waste. The risk of acidification caused by propionic acid accumulation in the kitchen waste anaerobic digestion reactor can be effectively eliminated, and stable operation of the system is ensured; fatty acid such as propionic acid is used as an important substrate for methane production and can be thoroughly utilized to further strengthen methane production, and the resource recycling rate of organic solid waste is effectively increased; the applicability of the kitchen waste anaerobic digestion reactor is further improved.

The present invention relates to the field of medical technology, and more particularly to a sleep-promoting pitaya fermentation liquor complex and a preparation method thereof, comprising the following raw materials in parts by weight: 65-70 parts of red pitaya fermentation liquor, 3-5 parts of microencapsulated lavender oil powder, 2-4 parts of synergistic microcapsule powder, 1.5-2.5 parts of a sweetness regulator, and 0.3-0.5 parts of a stabilizer; wherein the microencapsulated lavender oil powder is prepared with casein peptide-soybean lecithin as a shell material and lavender oil as a core material; the synergistic microcapsule powder is formed by cross-linking tannic acid with chitosan-carboxymethyl cellulose as a shell material and theanine, 5-hydroxytryptophan and piperine as a core material. The sleep-promoting pitaya fermentation liquor complex is prepared by processes such as homogenization, filling, and sterilization. The complex of the present invention can effectively help sleep, and the preparation method is simple, with broad application prospects.

The invention relates to an alkaloid liposome, a preparation process thereof and an application of the alkaloid liposome in an external preparation, and belongs to the technical field of external preparations. The technical problem to be solved is to provide an alkaloid liposome technology which is higher in stability, safe and non-irritating. According to the scheme, the alkaloid liposome technology is characterized in that raw materials comprise alkaloid, hydrogenated lecithin, grease, polyhydric alcohols and water; the alkaloid is selected from at least three of piperine, tetrahydropiperine, tetrahydropalmatine, dihydrooat alkaloid D, caffeine and leonurine; the hydrogenated lecithin is selected from at least one of PHOSPHOLIPON80H or PhoslipTM HPC (Hydroxyethyl Propyl Phosphatidylcholine). The liposome is good in stability and low in irritation, and has the effects of promoting local tissue microcirculation, reducing choked flow rate, increasing local body temperature, enhancing tissue metabolism and improving local inflammation when being externally applied to skin.

The invention relates to the technical field of cosmetics, in particular to an instant wrinkle-removing composition, application thereof and instant wrinkle-removing eye cream. The instant wrinkle-removing composition disclosed by the invention is prepared from the following components: a polypeptide mixture, dipalmitoyl hydroxyproline, tetrahydropiperine, a rabdosia amethystoides leaf / stem extract, a blackberry leaf extract, acetylated sodium hyaluronate, coenzyme Q10 and glycosylglycerol. The instant anti-wrinkle composition provided by the invention has the advantages of high active ingredient content and good anti-aging and anti-wrinkle effects. When the instant wrinkle-removing composition is used for instant wrinkle-removing eye cream, the obtained eye cream is good in permeability, the problem of periorbital wrinkles can be effectively relieved, the periorbital skin elasticity can be recovered, and the wrinkles can be reduced.

The invention relates to a flavor beverage capable of improving sleep and a preparation method thereof. Every 50ml of the flavored beverage comprises the following raw materials: a functional agent, a sweetening agent, an acidulant, a stabilizing agent and a solvent, the functional agent is prepared from 100 to 150 mg of gamma-aminobutyric acid, 2.5 to 3.5 g of resistant dextrin, 8 to 12 mg of long pepper extract powder, 6 to 10 mg of ginger extract powder, 12 to 18 mg of EGCG, 0.6 to 1.0 mg of L-phenylalanine compound, 3.0 to 4.5 mg of vitamin B6 and 1.5 to 2.25 mg of vitamin B2; the sweetening agent is prepared from 2.0 to 3.0 g of high fructose corn syrup, 0.4 to 0.6 g of fructose, 2.5 to 3.5 mg of acesulfame potassium and 1.2 to 1.8 mg of aspartame; the sour agent is prepared from 25 to 35 mg of vitamin C, 20 to 30 mg of citric acid and 3 to 5 ml of natural flavor extracting solution; the stabilizing agent is prepared from 5.0 to 7.0 mg of xanthan gum and 4.0 to 6.0 mg of glycerin monostearate; the solvent is purified water, and the total volume is 50ml; wherein the purity of the gamma-aminobutyric acid is greater than or equal to 99%, the piperine content in the long pepper extract powder is greater than or equal to 5%, and the gingerol content in the ginger extract powder is greater than or equal to 1%. The flavor beverage capable of improving sleep provided by the invention can mildly help sleep, and is high in bioavailability, healthy in taste, strong in stability, free of melatonin dependence and easy in mass production.

This invention discloses an ergothioneine-curcumin synergistic anti-inflammatory and anti-aging composite composition and its preparation method, relating to the fields of biomedicine and functional skincare technology. This invention constructs a ternary nanolipid carrier core-shell hierarchical structure consisting of a hydrophobic core, an interface-enhancing layer, and a hydrophilic shell. The hydrophobic core, formed by hydrogenated lecithin and phytosterols, provides a stable lipid microenvironment for curcumin. The oil-water interface region of the lipid bilayer utilizes its polar gradient to directionally anchor piperine molecules from black pepper extract, allowing piperine to be precisely positioned at the lipid membrane interface. The hydrophilic shell, composed of thiolated hyaluronic acid, covalently connects ergothioneine via thiol-disulfide bonds, stably fixing ergothioneine to the carrier surface. This allows it to exert its antioxidant protective effect upon contact with the skin or mucous membranes, while simultaneously preventing the migration and diffusion of ergothioneine into the inner lipid region. This achieves spatially ordered partitioning and functional synergy of the three active ingredients.

The invention provides a traditional Chinese medicine active ingredient composition for improving migraine through nasal administration. The traditional Chinese medicine active ingredient composition comprises the following traditional Chinese medicine active ingredients: tetrahydrojateorhizine, scopoletin, ferulic acid, isoferulic acid, piperlongumine and piperine. The invention also provides application of the traditional Chinese medicine active ingredient composition, and the traditional Chinese medicine active ingredient composition is used for preparing medicines for improving migraine through nasal administration. The traditional Chinese medicine active component composition can significantly inhibit LPS-induced BV2 nerve cell inflammation, and can be used for preparing drugs for improving migraine through nasal administration.

The invention relates to the technical field of combination of functional food and traditional Chinese medicine, and particularly discloses a beverage with a function of relieving muscular soreness after exercise and a preparation method thereof, the beverage comprises a white peony root extract, a honey-fried licorice root extract, a turmeric extract and a black pepper extract; the content of glycyrrhizic acid in the honey-fried licorice root extract is lower than 0.1%, and the content of piperine in the black pepper extract is not lower than 98%, and preparing and weighing the white peony root extract, the honey-fried licorice root extract, the turmeric extract and the black pepper extract; mixing with electrolyte and erythritol, and adding purified water to a constant volume to obtain a mixed solution; the mixed liquid is stirred and homogenized, and homogenized liquid is obtained; and performing sterilization treatment on the homogenized liquid, and then performing sterile filling to obtain the beverage. By forming a three-in-one synergistic scheme of spasmolysis, anti-inflammation and synergy, the invention provides the drink for recovering after exercise, which is safe and effective and has an easily accepted taste.

This invention relates to the field of food processing technology and discloses a method for improving the stability and bioavailability of astaxanthin by combining piperine with a whey protein fibrillary-algin complex. The method specifically includes the following steps: S1. Preparation of whey protein fibrillary; S2. Loading piperine onto whey protein fibrillary; S3. Complexation of piperine-loaded whey protein fibrillary with sodium alginate; S4. Preparation of an astaxanthin-piperine co-encapsulated emulsion. This invention constructs a three-dimensional network resistant to pepsin hydrolysis through electrostatic complexation; enhances the effective concentration of piperine in the intestine through co-encapsulation, efficiently regulating the expression of P-gp efflux transport proteins and the transmembrane absorption of astaxanthin; and utilizes the functional property of piperine to inhibit the activity of P-gp efflux transport proteins to achieve efficient absorption of astaxanthin.

The invention relates to the technical field of functional food, and discloses a traditional Chinese medicine for treating kidney deficiency and a preparation method of the traditional Chinese medicine. 250 to 350 parts of radix astragali seu hedysari; 120 to 180 parts of coix seeds; 80 to 130 parts of chicken's gizzard-membrane; 100 to 160 parts of phaseolus calcaratus; 40-60 parts of black ginger; 180 to 250 parts of L-arginine; 150 to 200 parts of polyvinylpyrrolidone K30; 1 to 3 parts of piperine; 4 to 6 parts of zinc gluconate; 200-250 parts of fried glutinous rice flour; and 100 to 150 parts of isomaltitol. Through synergistic compatibility, solid dispersion and targeted extraction technologies, the bioavailability and stability of active ingredients are improved, and a better synergistic effect is achieved.

Embodiments of the invention provide a herbal composition that may be utilized to ease suffering, to improve quality of life, and to relieve the symptoms of patients suffering from chronic diseases with reduced side effects. In some embodiments, it includes a product comprising a composition having an extract of an herbal spice comprising green tea, piperine and turmeric, wherein the composition has IC50 value for cytotoxicity less than or equal to about 10 micrograms / ml and the extract is extracted using an organic solvent comprising DMSO.

The present invention discloses an anti-inflammatory and antibacterial composition, and a preparation method and application thereof. The composition is obtained by compounding a turmeric plant extract and a Chinese herbal medicine extract, wherein the turmeric plant extract is a volatile oil extract of the turmeric plant; the Chinese herbal medicine extract contains houttuynia cordata extract, chrysanthemum extract, bupleurum extract, yew lily extract, andrographis paniculata extract, and capillaris extract; the properly matched composition has a significant synergistic effect and can enhance its anti-inflammatory and antibacterial effects. At the same time, the promotion of transdermal absorption of the composition was studied, and it was found that the piperine compounding scheme can significantly improve the transdermal absorption effect and improve the bioavailability of the composition. The anti-inflammatory and antibacterial composition of the present invention has the effects of clearing away heat and detoxifying, reducing swelling and draining pus, stopping bleeding and relieving pain, and anti-inflammatory and sterilizing. At the same time, it has the advantages of a short treatment course, high efficacy, no toxic side effects, no recurrence of the disease, and is not easy to develop drug resistance. It can be used to treat oral inflammation and pharyngitis.

The invention discloses a piperine derivative as well as a preparation method and application thereof, and relates to the technical field of medical chemistry. The invention provides a specific structural formula of the piperine derivative, and also provides a preparation method of the piperine derivative. The piperine derivative shows remarkable anti-proliferative activity and antifeedant activity, can be applied to development of natural botanical insecticides, and shows potential application value in the field of preparation of novel environment-friendly pesticides.

The invention discloses a piperine-based pseudo-natural dimer amide alkaloid compound 1 and a piperine-based pseudo-natural dimer amide alkaloid compound 2 as well as a preparation method and medical application thereof. Dimerization of piperine is realized through a visible light catalytic reaction system Ir (ppy) 3 / 465nm LED, and optically pure enantiomers 1a / 1b and 2a / 2b are obtained through acetonitrile-water system preparative HPLC separation and purification in combination with a chiral chromatographic resolution technology. HRESIMS, multi-dimensional NMR and X-single crystal diffraction confirm that the structure of the compound has a unique cyclohexene skeleton and a bis-piperidyl structure. A biological activity research shows that the target compound has a remarkable inhibition effect on LPS-induced RAW264.7 macrophage NO release, the compound 1 shows an excellent curative effect in an imiquimod-induced psoriasis mouse model, and the effect of the compound 1 is superior to that of a positive drug benvitimod. The invention provides a green and efficient photocatalytic synthesis method, and the obtained compound provides candidate molecules for developing multi-target anti-psoriasis drugs.

The invention provides composite particles for regulating and controlling bioavailability and tissue distribution of resveratrol and piperine and a preparation method of the composite particles, and belongs to the technical field of nutritional active ingredient delivery systems. According to the resveratrol-zein-lecithin-piperine-konjac glucomannan composite particle and the preparation method thereof, firstly, a particle core is formed through an anti-solvent coprecipitation method, then a piperine solution and a konjac glucomannan solution are sequentially injected, and the resveratrol-zein-lecithin-piperine-konjac glucomannan composite particle of a core-shell structure is formed through layer-by-layer assembly. Compared with a free form, the composite particle has the advantages that the physical and chemical stability of the resveratrol and the piperine is remarkably improved, the residence time of the resveratrol and the piperine in intestinal tracts is prolonged, and the oral bioavailability and the liver tissue enrichment capacity of the resveratrol and the piperine are effectively enhanced. The composite particle provided by the invention is clear in structure, the preparation method is simple and convenient to operate, and the composite particle has a good application prospect in functional food and drug development.

The invention provides a piperine compound as well as a preparation method and application thereof, belongs to the technical field of piperine derivatives, and aims to overcome the defect of poor water solubility of the piperine compound on the premise of not changing the structure of the piperine and ensure that the pharmacological activity of the piperine is not influenced.

This invention relates to novel feed additive compositions for use as preventative and therapeutic agents for fungal, viral, and bacterial infections in humans, animals, and aquatic animals, including white spot shrimp virus (WSSV) infection in aquatic species (including crabs and shrimp). The additive composition comprises glyceryl monolaurate, rosemary oil, nisin, calcium carbonate, piperine, sodium alginate, and carboxymethyl cellulose, and further comprises glyceryl monolaurate and a saponin-rich extract in proportions described herein. The additive composition can be used at lower concentrations for the prevention of WSSV infection in aquaculture species and at higher concentrations for the treatment of WSSV infection in aquaculture species. This invention also relates to a method for manufacturing the additive composition described above.