320 results about "Piperine" patented technology

An anti-aging composition comprising: (i) at least one biomimetic oligopeptide having a sequence of 20 amino acids or less; (ii) at least one lipoaminoacid; (iii) at least one pentacyclic triterpenoid selected from the group consisting of asiaticoside, madecassic acid, asiatic acid and madecassoside; (iv) at least one antioxidant; and (v) tetrahydropiperine; a kit comprising such composition and a method of use.

The present invention relates to a novel feed composition for animals, for example poultry, comprising as active ingredient benzoic acid, derivatives or metabolites thereof, in combination with a mixture of at least two active compounds selected from the group consisting of thymol, eugenol and piperine. The inventors found that in addition to the well known function of benzoic acid, this compound can be used as a potential growth promoter when it is combined with a mixture of at least two active compounds selected from the group consisting of thymol, eugenol and piperine. In particular the inventors have been able to demonstrate that a mixture of these chemical compounds present in different parts of plants, used in synergy and in combination with an appropriate amount of benzoic acid, exhibits, in totally unexpected manner, the effects sought by the present invention of improving the digestibility of poultry feed, i.e. for improving feed conversion ratio and/or daily weight gain in animal.

A pre-vaporization formulation pre-vaporization formulation for an e-vaping device, the pre-vaporization formulation including a vapor former including a combination of propylene glycol and glycerol, and an additive including at least one of capsicum, allyl isothiocyanate, piperine, isoeugenol, carvacrol, thymol, menthol, monomenthyl succinate, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropyl butanamide, horseradish oil, garlic extract, onion oil, black pepper, cayenne pepper, ginger oil, thyme oil, cinnamon bark oil, turmeric, fenugreek, cardamom, rosemary extract, grapefruit oil and andrographis extract.

A composition useful as a hydrating beverage comprising at least one complex carbohydrate, at least one chelated electrolyte, betaine, and piperine. The composition, which may be carbonated or non-carbonated beverage compositions and beverage concentrates adapted for all administration of water, physiologically essential electrolytes and other ingredients to a subject specifically adapted for enhancing hydration; preferably with enhanced absorption after ingestion while at the same time attenuating muscle fatigue and, preferably destroying harmful free radicals.

The invention relates to curcumin and piperine carried solid lipid nanoparticles. The curcumin and piperine carried solid lipid nanoparticles are prepared from 0.1-5% of curcumin, 0.1-5% of piperine, 10%-70% of solid lipid material, 5%-30% of liquid oil phase, 10%-60% of emulsifier and the balance of water by weight percentage. A preparation method of the curcumin and piperine carried solid lipid nanoparticles can be a thin film dispersion method, a micro-emulsion method or an emulsifying evaporation-low temperature solidification method. Compared with the existing forms, the curcumin and piperine carried solid lipid nanoparticles have the advantages that the solubility of the curcumin and piperine drugs is improved, the stability and the release degree in vitro of the drugs in the nanoparticles are improved and the effects of anti-tumor and inversion of multidrug resistance of the curcumin are enhanced.

The present invention relates to the combination of organic acid salts with at least one active ingredient of plant origin, preferably essential oils, partially protected with vegetable fats and/or oils, which prevent these active ingredients from being digested by stomach enzymes during the digestive process. The sodium salts of short-chain acids, preferably salts of butyric, acid are preferred. The preferred essential oils are ginger, piperine, oregano, garlic, thymol, carvacrol, cinnamaldehyde and/or any combinations thereof. The combination of organic acid salts and the essential oils protected with vegetable fats and/or oils, are used as powerful promoters or stimulants for animal growth, as organic bactericides against pathogenic bacteria present in said animals and as modulators of immune response thereof.

A composition and a method for using the composition to delay the onset of the symptoms of Alzheimer's disease in humans, comprising curcumin, piperine, oleic acid, oleanolic acid, ursolic acid, galantamine, and huperzine A, among other compounds. Curcumin is an antioxidant, while galantamine and huperzine A inhibit the activity of acetylcholinesterase in the brain. Piperine and oleic acid increase the bioavailability and gastrointestinal absorption of curcumin, galantamine, huperzine A, and other nutrients.

The present disclosure provides for a scientific formulation useful in the treatment and prevention of human and animal diseases. A biologically effective amount of each of the components of the formulation is administered to patients in pill (or capsule) form via multiple different and identifiable pills. The compounds of the formulation are segregated into different pill types, and contain various amounts of the compounds Curcumin, Genistein, Squalamine, Vitamin E, N-Acetyl-Cysteine, Methylselenocysteine, Zinc Gluconate, B Complex, Lentinen, Coenzyme Q10 Acetyl-L-Carnitine, Lipoic Acid, Resveratrol, and Vitamin C. Furthermore, Arabinoxylan and/or Peperine may be added to the various pill formulations.

The invention discloses a piperine deinsectization bactericidal agent by taking the piperine as an effective component and is prepared by mixing piperine, natural pyrethrin, matrine, hodorine, nicotine, synergistic agent, preservative, emulsifier, surface active agent, stabilizer, pH regulator, defoamer and solvent. The invention belongs to a plant source deinsectization bactericidal agent with the advantages of unambiguous effective components and easily controlled product quality, which adopts a proper accessory ingredient such as the emulsifier and stabilizer, etc., to solve the key problems of degradation and unstable quality and has no toxicity and residue, environment-friendliness and broad-spectrum effective deinsectization bactericidal effect. The invention has remarkable killing and controlling effects on various pests and germs in wheat, rice, fruit trees, vegetables, flowers, storehouses, houses as well as forests, has remarkable controlling effects on sanitary insect pests and germs like mosquito, fries, black beetles, ants, bedbugs, moth flies and fleas, etc, which is used for controlling pests and various germs for grains like paddy, wheat, corn, broomcorn, etc., during a storage period with a remarkable effect.

The present invention relates to a process of making high purity piperine for nutritional and nutraceutical application. This process recovers piperine from piperine-containing oleoresin by using isourea, urea or a urea derivative to remove organic matter other than piperine from the oleoresin. Preferrably, the process recovers piperine from oleoresin of fruit of piper nigrum or piper longum. More preferably, the process recovers piperine from oleoresin of fruit of piper nigrum, i.e. black pepper.

The invention discloses a method for extracting black pepper essence oil and black pepper essence oil resin from black paper, which comprises the following process steps: (1) purifying a black pepper raw material and crushing and sieving to obtain black paper powder; (2)placing black paper powder into a steam distillation tank, introducing steam to distill essence oil, cooling oil-water mixed steam to obtain oil and water mixed liquid, separating oil from water in the oil water mixed liquid, removing bottom water and obtaining top black pepper essence oil; and (3) drying the black paper powder in which the essence oil is distilled completely, putting the dried black paper powder in an extracting device, adding an extraction solvent to perform extraction, filtering extraction solution, evaporating, concentrating and thus, obtaining olive-green paste namely black pepper oil resin. When the method is used, the essence oil yield reaches over 95 percent, and the piperine yield reaches over90 percent; and the solubility of the obtained product is high, and the use in food production is promoted. In the invention, the processing method is simple and has high production efficiency and high application value.

Disclosed are sustained-release medicaments/drug compositions/formulations/therapeutics for the management of pain and inflammation associated disorders in general, more particularly arthritic inflammation. The sustained-release compositions comprise effective amounts of glucosamine, curcuminoids, boswellic acids and piperine.

The invention discloses a water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, a method for preparing the same and application of the water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule. The water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule comprises, by weight, 1-20% of coenzymes Q10, 0.1-1% of piperine, 0.05-5% of antioxidants, 30-60% of carrier oil, 0.05-5% of oil-phase surfactants, 0.05-5% of water-phase surfactants and 20-50% of water-phase wall materials. The water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule, the method and the application have the advantages that the water-soluble nanometer sustained-release functional coenzyme Q10 micro-capsule is good in stability and convenient to process, and components can be prevented from being destroyed.

The invention belongs to the technical field of medicine, and discloses curcumin nanosuspension and a preparation method of the curcumin nanosuspension. As curcumin is poor in stability, small in solubility and low in oral bioavailability, popularization and use of the curcumin are restricted. The curcumin nanosuspension disclosed by the invention is characterized by containing the curcumin, piperine, and zein, and the mass ratio of the curcumin to the piperine to the zein is 10 to (8-9) to (1-2). The preparation method of the curcumin nanosuspension disclosed by the invention is mild in condition, simple and controllable, and the curcumin achieves high oral bioavailability.

The invention provides pearl capsule with twenty-five components, a preparation method and a quality detection method thereof. The preparation method includes steps of dividing the twenty-five medicinal materials into four parts, namely mineral and precious medicine, precious and refine medicine, medicinal material containing volatile oil and medicinal material containing water-soluble components, crushing the mineral and precious medicine to 80 mesh, uniformly mixing; crushing the medicinal material containing high volatile oil to crude powder, extracting volatile oil, using beta-cyclodextrin for clathration; carrying out water extraction for the medicinal material containing water-soluble components, concentrating to relative density of 1.25-1.35 under reduction pressure, mixing the three parts, drying at 60-80 DEG C, crushing to 80 mesh; respectively grinding the precious and refine medicine, namely buffalo horn concentrated powder, cow-bezoar and musk into fine powder, mixing, adding beta-cyclodextrin and dextrin for mixing, and packaging into capsule. The high efficiency liquid chromatogram method is used for detecting content of piperine, and the thin layer chromatography method is used for discriminating nine objects.

The invention relates to an establishment method of a peperine and moisture content quantitative model by the near infrared spectrum technology and application of method in evaluation of the quality of white pepper. The method comprises the following steps of: a combination method for collecting samples, a spectrum collection method, the establishment of a quantitative model of peperine and moisture content in the white pepper by a chemometrics method, and sample determination by correcting temperature factors by intercept compensation. According to the model establishment method, the influence on the spectrum caused by diversity, complicity and temperature of a sample can be overcome by adopting the combination of multiple samples and extracting the characteristic spectrum which is high related with peperine and moisture, and the accuracy of the model and the accuracy of a predicted value can be effectively improved, so that a method for simply and quickly determining the peperine and moisture content in the white pepper and evaluating the quality is provided.

The invention discloses a quality detection method of a Zhenlong brain-refreshment preparation. The method provided by the invention comprises a discrimination method of piper longum, banksia rose, Chinese cassia tree, gallic acid, cardamom, clove, pearl, cholic acid, stigma croci and cinnamaldehyde as well as a discrimination method of piperine in piper longum, cholic acid in cow-bezoar, cinnamaldehyde in Chinese cassia tree, and crocin-I and crocin-II in stigma crociand. Through a test research, by the discrimination methods in the quality detection method of the test article chromatograph,spots with the same color are shown on the corresponding position of control article chromatograph without the interference of negative control. The method is convenient and feasible with strong character. The content detection method provided by the invention is used to detect the contents of piperine, cholic acid, crocin-I and crocin-II in the Zhenlong brain-refreshment preparation. The result shows that the method has good linear relation, high accuracy of a recovery test and good repeatability and stability, and can be used to accurately and rigorously control the quality of the Zhenlong brain-refreshment preparation.

A deep restoration mask is made through dipping a liquid in mask paper, and 1000 parts of the liquid are prepared from, by weight, 0.1-3 parts of micro-molecular hyaluronic acid, 0.1-2.5 parts of macromolecular hyaluronic acid, 0.7-30 parts of synthetic egg white powder, 1-7 parts of an aloe extract product, 0.7-9 parts of propylene glycol, 5-50 parts of 1,2-butylene glycol, 5-30 parts of glycerin, 20-80 parts of a licorice root extract liquid, 20-80 parts of a gherkin extract liquid, 20-80 parts of a Fructus Arctii extract liquid, 20-80 parts of a ginkgo extract liquid, 2-10 parts of water-soluble alpha-bisabolol, 10-50 parts of water-soluble mint oil, 5-20 parts of rose hydrolat, 0.1-1 part of apple stem cells, 0.5-5 parts of silk peptides, 0.1-1 part of tetrahydropiperine, 5-20 parts of water-soluble vitamin E nicotinate, and the balance of water. Effective components of the mask can be fast absorbed, can accelerate restoration of damaged skins, cause no irritation or allergy, and are suitable for all skin types.

The invention discloses a skin care product composition containing saccharomycetes fermentation product filter liquor. The composition mainly contains 0.2-8% of saccharomycetes fermentation product filter liquor, 0.2-5% of saccharomycetes/barley seed fermentation product filter liquor, 0.2-5% of saccharomycetes/coix seed (COIX LACRYMA-JOBI MA-YUEN) fermentation product filter liquor, 0.2-5% of saccharomycetes/grape fermentation product extract and 0.1-1.5% of tetrahydro piperine. The skin care product composition containing the saccharomycetes fermentation product filter liquor combines the natural active ingredients, can permeate the skin surface well in a coalitive synergism mode to be absorbed, enters deep circulation and systemic circulation to make the skin smooth and tender, and has excellent effects of moisturizing, preventing ageing and whitening and tendering the skin.

The present invention relates to a bioenhancing/bioavailability-facilitating composition comprising: an effective amount of an extract and/or at least one bioactive fraction from Cuminum cyminum; one or more additive selected from drugs, nutrients, vitamins, nutraceuticals, herbal drugs/products, micro nutrients, antioxidants along with pharmaceutically acceptable additives/excipient, and optionally, an effective amount of piperine or extract/fraction of piper nigrum or piper longum; and a process for the preparation of such extracts and active fractions from plant Cuminum cyminum.

The invention discloses a total alkaloids extractive of piper hancei and application thereof, belongs to the technical field of medicine, and in particular relates to a total alkaloids extractive of traditional Chinese medicine piper hancei and application thereof. The extractive is obtained from the traditional Chinese medicine piper hancei, and comprises the following alkaloid components: sinoacutine amide, hairy grama piperine, long pepper amide A, pepper a-amanitine, Guinea pepper, piperine, piperettine, piperovatine, N-p-tonka-bean acyl tyramine, N-trans- asafetida acyl tyramine, birthwort lactam AIIIa, birthwort lactam II, and 2E, 4E-N- isobutyl-7-3,4-methinedioxy phenyl-2, 4-diene heptamide, long pepper nerinine and a derivate thereof, wherein the total content of the total alkaloids components is counted by 5 to 100 percent by weight.

The invention discloses a quality detection method related to a Ruyi Zhenbao preparation. The method comprises a qualitative identification method for banksia rose, dalbergia wood, clove, long pepper, safflower, cassia seeds and gallic acid and a content determination method for safflower yellow A in safflower, piperine in long pepper and cholic acid in bezoar. According to tests and research, when a sample is tested by using the identification method in the quality detection method provided in the invention, spots appear at positions on a chromatogram of the tested sample corresponding to positions where spots with same colors appear on a chromatogram of a contrast sample; negative controls produce no interference; the identification method is simple, feasible and remarkably characteristic. When the content determination method in the invention is used for determining the content of hydroxysafflower yellow A, piperine and cholic acid in the Ruyi Zhenbao preparation, it is proved thata good linear relation is obtained, that accuracy of tests of a recovery rate is high, that very good repeatability and stability are achieved and that accurate and strict control of quality of the the Ruyi Zhenbao preparation can be realized.

The invention relates to a method for preparing black pepper oil resin, which comprises a flaking and crushing machine, a supercritical extraction kettle, a separation kettle, a molecular distillation device and a black pepper oil resin blending device, wherein the flaking and crushing machine is used for crushing flaked black pepper with water content being below 13 percent, and the crushed flaked black pepper enters the supercritical extraction kettle; the supercritical extraction kettle is used for extracting the black pepper powder, the extraction solvent is carbon dioxide of good grade, the total time of the extraction is 3-4h; the separation kettle is used for separating fluid with extract to obtain a crude extract, wherein the fluid with the extract enters the separation kettle; the molecular distillation device is used for separating and removing impurities of water and the like from the crude extract and separating into light components and heavy components, the light components are mainly black pepper oil and account for more than 70 percent, the heavy components are mainly piperine and account for more than 50 percent; and the black pepper oil resin blending device comprises an edible plant oil metering valve, a black pepper essential oil metering valve and a piperine metering valve, and the black pepper oil resins with different specifications are blended from the black pepper essential oil, the piperine and the edible plant oil according to a certain proportion. The device has the advantages of simple structure and high efficiency and can be used for preparing sensoner with top-grade catering industry.

The invention relates to a natural medicinal composition, a preparation method thereof and application thereof to the preparation of medicaments for attenuation and synergia in cancer radiochemotherapy. The natural medicinal composition is prepared from decocting concentrated extract of ginger and white pepper, gingerol, water extract of the white pepper and piperine according to a ratio of (1-3):(3-5):(4-8):(2-9). The composition has the good curative effect on side effects such as vomit caused by the cancer radiochemotherapy and also can play the role in inhibiting tumors simultaneously.

The invention provides compound turmeric lipid cubic liquid crystalline nano-particles and a preparation method thereof. The compound turmeric lipid cubic liquid crystalline nano-particles comprise the following components in parts by weight: 0.05-0.15g of phytantriol, 20-30mg of F127, 5-7mg of turmeric, 1-3mg of piperine and 15-25mL of water. Compared with a raw medicine group consisting of turmeric and piperine, the compound turmeric lipid cubic liquid crystalline nano-particles provided by the invention are significantly improved to show the properties that the in-vitro stability and solubility of turmeric can be improved on the one hand, the in-vivo bioavailability of turmeric can be significantly improved on the other hand, slow release and targeting effects can also be achieved, and the curative effects of turmeric on therapy in vivo can be enhanced so as to lay a foundation for turmeric to play the extensive pharmacological effects of resisting tumor, improving cardiovascular functions, resisting inflammation, resisting virus, protecting the liver and enhancing the immunity.