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Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated

A desired effect is produced by therapeutically activating tissue at a first site within a patient's body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient's body by applying high frequency stimulation and / or direct current pulses at or near the second site. Time-varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be promotion of micturition or defecation and the undesired side effect may be sphincter contraction. The desired effect may be defibrillation of the patient's atria or defibrillation of the patient's ventricles, and the undesired side effect may be pain.
Owner:MEDTRONIC INC

Photoirradiation thermal processing apparatus and thermal processing susceptor employed therefor

A susceptor is formed with a cavity having a tapered surface and a receiving surface. The gradient α of the tapered surface with respect to the receiving surface is set to at least 5° and less than 30°, so that a semiconductor wafer received by the susceptor can be located on the receiving surface through the tapered surface while the semiconductor wafer can be protected against excess stress also when the surface of the wafer abruptly thermally expands due to flashlight irradiation and can be prevented from cracking in thermal processing. Thus provided are a thermal processing susceptor and a thermal processing apparatus capable of preventing a substrate from cracking in thermal processing.
Owner:DAINIPPON SCREEN MTG CO LTD

Network security planning architecture

Described are techniques used for assessing the security of a network. Pruned attack trees are generated using a forward chaining, breadth-first technique representing the attack paths of a possible attacker in the network. A vulnerability score is determined for each network and attacker starting point using attack loss values assigned to each host and information extracted from the attack tree(s) concerning compromised hosts. Different hypothetical alternatives may be evaluated to improve security of the network and each alternative may be evaluated by recomputing the network vulnerability score and comparing the recomputed score to the original network vulnerability score. Also disclosed is a method for determining end-to-end connectivity of a network. The resulting end-to-end connectivity information is used in generating the pruned attack tree.
Owner:MASSACHUSETTS INST OF TECH

Walk simulation apparatus for exercise and virtual reality

A locomotion platform device enables a user to perform a simulation of various motions including walking and running. The device comprises a locomotion platform having a concave upward facing surface. The platform and / or the user's footwear incorporate a mechanism to reduce friction between the user and the surface of the platform in order to allow the user's feet to move freely.
Owner:WILLIAMS JULIAN D

Systems and methods for performing or creating simulated phishing attacks and phishing attack campaigns

ActiveUS20170251009A1Risk minimizationMalicious action is preventedTransmissionElectronic mailData library
A method for establishing a campaign for a simulated phishing attack includes receiving, via a campaign manager, specification of a plurality of parameters for a campaign including at least an identifier of a campaign and identification of users to which to send the campaign, establishing, via the campaign manager, a type of exploit for the campaign and one or more types of data to collect via the type of exploit, storing, by the campaign manager, the campaign comprising the plurality of parameters, and identifying, by a simulation server, the campaign stored in the database to create a simulated phishing email, to be sent to email accounts of the users, using the plurality of parameters of the campaign, wherein the simulated phishing email is to be created to have a link to a landing page comprising the type of exploit and configured to collect the one or more types of data.
Owner:KNOWBE4 INC

Recording/reproducing system, recording medium device, and recording/reproducing device

A memory card and a recording / playback device are provided that are capable of deterring a memory card manufacturer from illicitly storing a same media ID on a plurality of memory cards. A memory card (100) includes a media ID storage module unit (610) and a memory unit (120). The media ID storage module unit (610) includes a media ID storage unit (611) that stores therein a media ID that is specific to the memory card, and a certification unit (609) that generates certification information that certifies the validity of the memory card based on the media ID. The memory unit (120) includes an encrypted content storage unit (122) for storing encrypted digital content. The recording / playback device (200) includes a memory card verification unit (200) that acquires the certification information from the memory card (100), verifies the validity of the memory card (100) based on the acquired certification information, and when the verification has failed, prohibits decrypting an encrypted content or encrypting a content, and a content encryption unit (209) that, when the verification has succeeded, encrypts the digital content or decrypts the encrypted digital content.
Owner:PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO LTD

Mobility aiding device

The present invention relates to a mobility aiding device, such as a walker, a wheelchair, a transport chair, a shower seat or a rollator, for use in providing support to injured or ailing persons during activity or movement. According to the present invention a solid two-piece seating platform is provided with a structural support for distributing the weight of the user to the frame. Furthermore, the two pieces of the seating platform are inter-hinged, enabling the entire device to fold up into a storage position. A lock is provided for maintaining the structural support in place, and a handle is provided for facilitating folding the device into the storage position.
Owner:DANA DOUGLAS +1

Systems and methods for creating and running heterogeneous phishing attack campaigns

ActiveUS20170251010A1Risk minimizationMalicious action is preventedTransmissionEngineeringHeterogeneous network
A method for creating a plurality of campaigns for simulated phishing attacks includes creating, by a campaign manager, a plurality of campaigns for simulated phishing attacks having a plurality of parameters including at least a time schedule, each of the plurality of campaigns having at least one parameter different than other campaigns of the plurality of campaigns, and identifying, by a simulation server from the database, a first campaign and a second campaign from the plurality of campaigns from which to create a first simulated phishing email to send on a first time schedule to email accounts of users of the first campaign, and a second simulated phishing email to send on a second time schedule, different than the first time schedule, to email accounts of users of the second campaign.
Owner:KNOWBE4 INC

Method and system for predictive enterprise resource management

A system and method are disclosed which predict whether a performance problem within a network is likely to be encountered during future operation. Furthermore, a preferred embodiment not only predicts the likelihood of a performance problem, but further determines the appropriate preventative measures to be taken in an attempt to prevent a predicted performance problem from occurring. In a preferred embodiment, a management system (MS) that oversees the operation of a network is implemented to predict likely performance problems within the network, and may determine appropriate preventative measures for preventing predicted performance problems within the network. Polling gateway(s) may be utilized to periodically poll the network resources in order to retrieve status information for such resources, including but not limited to status of disk(s), database(s), memory, CPU(s), and operating system(s) within the network. The gathered status information is then evaluated by the MS by, for example, correlating such status information with known performance rules for the network to predict potential performance problems, and based on such evaluation, the MS may predict whether a future performance problem is likely to be encountered. Once a future performance problem has been predicted, the MS determines an appropriate preventive action for preventing the performance problem from occurring, and the MS may initiate the appropriate preventive action before the occurrence of the predicted performance problem in an attempt to prevent such performance problem. Most preferably, the network management system is implemented to “learn” symptoms of performance problems over time.
Owner:OBJECTIVE SYSTEMS INTEGRATORS

Distributed energy services management system

Systems and methods for distributed energy services management are disclosed. A particular embodiment includes: receiving an input command via a network interface at a site gateway, the input command including information for controlling one or more physical devices at a site; converting, by use of a data processor, the input command to a virtualized command in a common command format; executing, by use of the data processor, one or more executor modules to cause execution of one or more corresponding virtual devices associated with the virtualized command; and using the executed one or more virtual devices to control the corresponding one or more physical devices at the site.
Owner:SUNVERGE ENERGY

Height-adjustable cordless brake

The present invention relates to a cordless braking system for a mobility-aiding device, such as a wheeled walker (a rollator) or a transport chair. The cordless braking system includes a brake actuating linkage, disposed inside the leg and handlebar members of the mobility-aiding device, which extends during height adjustment of the handlebars. The brake-actuating linkage and the leg / handlebar of the mobility-aiding device are designed to enable a locking pin or bolt to extend all the way therethrough to ensure that all of the height-adjustable members are secured together during use.
Owner:RANDOM PRODS TRUST +1

Concatameric immunoadhesion

Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
Owner:MEDEXGEN

System for toll payment and transportation management

An object of the present invention is to pay a toll without stopping a car and without providing a special lane for electronic payment, thereby reducing a traffic jam. The toll payment system comprises a portable telephone on a car, a base station connected with the portable telephone, a server connected with the base station. The server comprises a first memory for storing a location of the base station, a second memory for storing a unit price for each section along the highway and data identifying a contractor or contracted car, a driving route identification unit for identifying a driving route on the basis of the location stored in the first memory and a base station connected under a certain manner, a toll calculation, and a charging unit.
Owner:NEC CORP

Dynamic membership management in a distributed system

Transactional database replication techniques are disclosed that do not require altering of the database management system implementation. A replicator module includes a dynamic membership manager, which is configured to manage the persistent membership of a coordination group. The persistent membership can be, for example, a durable set of sites that can replicate changes amongst themselves. Changes from sites not in the persistent membership are discarded. The set of recovered members is a subset of the persistent membership. The persistent membership changes incrementally by either removing or adding members. Failed members may still be part of the persistent membership. The dynamic membership manager module manages the modification of the persistent membership, initialization of replicas, and propagation of membership information.
Owner:PROGRESS SOFTWARE

Pyrazole derivatives as cannabinoid receptor antagonists

InactiveUS20060100208A1Inhibit bindingBlock biological actionBiocideOrganic chemistryPyrimidine analogueChemistry
One aspect of the invention is concerned with cannabimimetic pyrazole analogs. Another aspect of the invention is concerned with new and improved pyrazole analogs having high affinities and / or selectivities for the CB1 cannabinoid receptor. A further aspect of the invention is concerned with pharmaceutical preparations employing the inventive analogs and methods of administering therapeutically effective amounts of the inventive analogs to provide a physiological effect.
Owner:UNIV OF CONNECTICUT

Splittable multicomponent elastomeric fibers

Thermally divisible multicomponent fibers having at least a first component including an elastomeric polymer and at least a second component including a non-elastomeric polymer. The multicomponent fibers are useful in the manufacture of nonwoven structures, and in particular nonwoven structures used as synthetic suede and filtration media.
Owner:FIBER INNOVATION TECH +1

Methods for preventing and treating tissue damage associated with ischemia-reperfusion injury

InactiveUS20090017031A1Reduce morbidityReduce mortalityPeptide/protein ingredientsImmunoglobulins against animals/humansThoracoabdominal Aortic AneurysmsComplement lectin pathway
A method for preventing or treating tissue damage associated with ischemia-reperfusion injury and thoraco-abdominal aortic aneurysm (TAAA) repair by administering a tissue damage preventing or treating amount of a complement inhibitor to a patient likely to suffer from or suffering from tissue damage associated with ischemia-reperfusion injury or TAAA repair. The complement inhibitors are preferably antibodies that bind to and inhibit complement proteins involved in the formation of the membrane attach complex, preferably antibodies that inhibit MBL, MASP1, MASP2, and MASP3 in the lectin pathway. The complement inhibitors can be used alone or in combination to decrease the morbidity and mortality caused by tissue damage associated with ischemia-reperfusion injury or TAAA repair.
Owner:GENENTECH INC

Tumor necrosis factor-gamma

Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and / or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
Owner:HUMAN GENOME SCI INC

Wastewater treatment apparatus and method for removing nitrogen and phosphorus

Provided is a wastewater treatment apparatus for removing nitrogen and phosphorus having an anaerobic tank, an anoxic tank, an aerobic tank and a clarifier, wherein the aerobic tank includes has a baffle installed at one side thereof to form a dissolved oxygen reducing zone for reducing the concentration of dissolved oxygen contained in internally recycled wastewater returned from a dissolved oxygen reducing zone while increasing the concentration of dissolved oxygen contained in treated effluent supplied from a part other than the dissolved oxygen reducing zone of the aerobic tank to a clarifier in a subsequent stage. Since organic matter present in wastewater is effectively used, the efficiency of removing nitrogen and phosphorus can be increased and the amounts of oxygen required throughout the treatment process and organic matter required for denitrification can be reduced. Also, synthesis of cells of microorganisms is suppressed. Therefore, the repair and maintenance costs can be reduced.
Owner:SAMSUNG ENGINEERING CO LTD

Reagent container and slide reaction and retaining tray, and method of operation

ActiveUS20060171857A1Promote capillary action induced fluid flowPrevent capillary actionAnalysis using chemical indicatorsSamplingTissue specimenBiomedical engineering
A sample, or slide, retaining tray includes a reagent reservoir, or recess, and a reaction chamber. A slide, or other sample container, can be positioned on the sample retaining tray as desired, with a tissue specimen face down, between a platen on the tray and the slide. A reagent from the reservoir is rendered flowable, such as by heating, and flows from the reservoir into the reaction chamber. Optionally, reagents or other fluids can be provided from above, by dripping onto a drip surface of the sample retaining tray, or below via an inlet port in the platen.
Owner:SAKURA FINETEK U S A

Warming and nonirritating lubricant compositions and method of comparing irritation

This invention relates to substantially anhydrous warming, non-toxic and nonirritating lubricating compositions containing polyhydric alcohols and an insulating agent as well as gel and jelly compositions related thereto. The invention also relates to methods of using such compositions for lubrication, administration of active ingredients and for preventing or treating dysmenorrhea.
Owner:RECKITT BENCKISER HEALTH LTD +1

Heterocyclic compounds and their use as angiotensin antagonists

InactiveUS6100252AHigh yieldPotent angiotensin II receptor antagonistic activityBiocideNervous disorderDiseaseHeart disease
Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases and heart diseases (e.g. hypercardia, heart failure, cardiac infarction), strokes, cerebral apoplexy, nephritis, atherosclerosis, Alzheimer's disease, senile dementia, etc.
Owner:TAKEDA PHARMACEUTICALS CO LTD
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