17 results about "HYPERTENSIVE DISEASES" patented technology

The invention relates to the technical field of old-age service management, in particular to an integrated old-age service management system based on end-cloud collaboration, and aims to solve the problems that in the prior art, multi-source data of physical signs, medication and living habits cannot be integrated to predict the health change trend, abnormal fluctuation of four high cannot be perceived in advance, short-term risks cannot be pre-judged, and the service quality is poor. And a personalized intervention scheme cannot be formulated in combination with reinforcement learning. Multi-source data of physical signs, medication and living habits are integrated through the chronic disease management module, LSTM is used for predicting the health change trend, four-high abnormal fluctuation is perceived in advance, short-term risks are pre-judged, a personalized intervention scheme is formulated in combination with reinforcement learning, diet and exercise suggestions and medication reminding are covered, and the system has the advantages of being simple in structure and convenient to use. User compliance is improved by outputting custom prompts through natural languages, the system forms a complete closed loop, the system is suitable for long-term management of diabetes and hypertension diseases, the risk of acute events is reduced, and the self-management ability of patients is enhanced.

The invention discloses an application of a small molecular compound SR9009 in preparation of antihypertensive drugs. The SR9009 is used for treating three common hypertension rodent animal models, a better antihypertensive effect is shown, the antihypertensive effect is possibly related to increase of urine sodium excretion and reduction of kidney epithelium sodium channel protein expression, possibility is provided for application of the SR9009 in prevention and treatment of hypertension diseases, and the SR9009 has a wide application prospect.

The invention relates to application of taurochenodeoxycholic acid in preparation of a medicine for preventing and treating hypertension. The key effect of the taurochenodeoxycholic acid in prevention and treatment of hypertension is found for the first time, that is, the taurochenodeoxycholic acid can significantly enhance the diastolic function of arteriole of a hypertensive patient, so that the effect of reducing blood pressure is achieved. Therefore, the invention provides a new application of taurochenodeoxycholic acid in preparation of the medicine for preventing and treating hypertension, a new medicine for preventing and treating hypertension is provided clinically, and the taurochenodeoxycholic acid has a good clinical application value and a wide application prospect. The taurochenodeoxycholic acid can be prepared into a medicine, a pharmaceutical composition, food, a health care product or a food additive by utilizing the key effect of the taurochenodeoxycholic acid in hypertension diseases, can be used for treating hypertension diseases including primary hypertension and salt-sensitive hypertension, and has important application value.

The invention relates to the field of traditional Chinese medicines, in particular to a preparation method of an Anqi flat-pressing capsule which comprises the following components in parts by weight: 6-7 parts of astragalus membranaceus, 6-7 parts of codonopsis pilosula, 4g of salvia miltiorrhiza, 5-6 parts of cortex moutan, 5-6 parts of malt, 5-6 parts of hawthorn, 3-4 parts of scutellaria baicalensis, 3-4 parts of radix bupleuri, 2.5 g of diazepam, 1-2 parts of nimodipine and 2-3 parts of radix isatidis. The capsule has the effects of nourishing heart, stabilizing mind, promoting blood circulation to remove blood stasis, soothing liver-qi stagnation, dredging and regulating internal organs, regulating qi activity, reducing heart pressure, maintaining normal functions of the heart, enabling qi and blood to be smooth and smooth, coordinating functions of the internal organs, reducing resistance and reducing blood pressure, so that the heart is protected against mind, and the main mind is relieved if the main mind is relieved. The capsule has the advantages of normal heart function, reduced pressure, relatively stable blood pressure, smooth qi and blood, healthy body and no occurrence of diseases, can be used for treating various hypertension and intractable hypertension diseases, and has no side effect.

The invention provides a traditional Chinese medicine composition and a preparation method thereof, and belongs to the technical field of traditional Chinese veterinary medicines, and the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: spring eyes, cynanchum otophyllum, moonwort, gordon euryale seed and the like. The traditional Chinese medicine composition belongs to a pure traditional Chinese medicine preparation, has the effects of calming liver and reducing blood pressure, clearing heat and eliminating phlegm, and tonifying kidney and spleen, and has the advantages of remarkable treatment effect, high blood pressure reducing speed, no toxic or side effect and the like on dog hypertension diseases. The traditional Chinese medicine composition provides a new theoretical data basis and thought for treating the dog hypertension, and has wide market potential in treating the pet dog hypertension diseases.

Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sFlt-1 antibody and an anti-sEng antibody bound to a solid support in order to reduce blood levels of sFlt-1 and sEng. The present disclosure relates to methods, systems, devices, and apparatuses for treating pregnancy-related hypertensive disorders such as pre-eclampsia and eclampsia.

The invention discloses a traditional Chinese medicine composition for preventing and treating pregnancy complications as well as a preparation method and application thereof. The composition is composed of medicinal and edible traditional Chinese medicines including radix rehmanniae recen, fructus gardeniae, gastrodia elata, fructus lycii and exocarpium citri rubrum, and mulberry leaves, ramulus uncariae cum uncis and the like can be selectively added. The preparation method comprises the steps of extracting volatile oil by steam distillation, leaching by a solvent, concentrating, mixing and the like, and can be combined with ultrasonic crushing to strengthen extraction. The composition is based on the treatment method of nourishing kidney, containing wood, clearing heat, calming liver, dissolving turbidity and preventing miscarriage in traditional Chinese medicine, has the effects of multi-target synergistic pressure reduction, proteinuria improvement and fetal development promotion aiming at the pathogenesis of yin deficiency and yang hyperactivity in the gestation period, is high in safety and free of fetal toxic and side effects, and is suitable for prevention and treatment of hypertensive diseases in the gestation period such as preeclampsia and the like.

A method of treating or preventing eclampsia, pre-eclampsia, hypertensive disorder of pregnancy, or HELLP syndrome in a patient including contacting blood from the patient that contains circulatory soluble fms-like tyrosine-kinase-1 (sFLT-1) with an ex vivo filter, said filter having immobilizcd-hcparin or -heparin fragment, the immobil ized-heparin or -heparin fragment capable of binding the sFLT-1 under the contact conditions in the filter. Next, allowing sufficient time for the binding the sFLT-1 to yield depleted blood with less of the sFLT-1 and then returning the depleted blood to the patient to treat or prevent the eclampsia, pre-eclampsia, hypertensive disorder of pregnancy in the patient. Additionally, a system for performing the method of treating or preventing eclampsia, pre-eclampsia, hypertensive disorder of pregnancy, or HELLP syndrome in a patient.

The invention provides a construction method and application of an intractable hypertension animal model, and particularly belongs to the technical field of disease animal model construction. The invention provides a construction method of an intractable hypertension animal model, which comprises the following steps: giving high-salt diet to spontaneously hypertensive rats every day, combining with intraperitoneal injection of N '-nitro-L-arginine and subcutaneous injection of testosterone propionate, and continuously administration for 2 weeks to complete modeling. The animal model with the blood pressure difficult to control is constructed, and an experimental tool is provided for scientific research requirements of deep fundamental research, treatment target screening, drug research and development, clinical transformation and the like of refractory hypertension diseases.

The present invention provides a DNA methylation segment combination and application for predicting hypertensive disorder complicating pregnancy, a method and device for predicting hypertensive disorder complicating pregnancy, wherein the method utilizes screened peripheral blood DNA methylation segments and adopts a logistic regression method to construct a risk prediction model for hypertensive disorder complicating pregnancy, calculates the risk value of hypertensive disorder complicating pregnancy, and thus can effectively predict the risk of hypertensive disorder complicating pregnancy.

Disclosed are methods and apparatuses for treating a pregnancy related hypertensive disorder, such as pre-eclampsia and eclampsia, using ex vivo treatment with an anti-sEng antibody bound to a solid support in order to reduce blood levels of sEng. The present invention provides a method of treating or preventing a disorder associated with soluble Endoglin (sEng), such as a pregnancy-related hypertensive disorder, in a subject in need thereof comprising providing ex vivo to the subject anti-sEng antibodies or sEng-binding fragments thereof in an amount sufficient and for a time sufficient to decrease the subject's blood levels of sEng to treat or prevent the disorder associated with sEng in the subject.

The invention discloses a biomarker composition and application thereof, and belongs to the field of biomarker analysis and detection. The invention firstly provides a group of biomarker compositions, wherein the biomarker compositions comprise a Klotho protein and a neutrophil gelatinase associated lipocalin (NGAL); the combined detection biomarker composition can be used for early assessment of the risk of hypertensive disorder in pregnancy complicated with acute kidney injury. When the marker composition is used for predicting the risk of hypertensive disorder in pregnancy complicated with acute kidney injury, the risk of acute kidney injury can be recognized in advance in the early pregnancy stage.

The present invention relates to novel sublingual compositions comprising an anti-fibrotic agent, as well as methods for their preparation. Wherein the composition comprising an anti- fibrotic agent such as pirfenidone or nintedanib and its analogs or pharmaceutically acceptable salts thereof. These novel sublingual compositions are intended for use in the treatment of fibrotic diseases, disorders, or conditions, such as idiopathic pulmonary fibrosis (IPF), and hypertensive diseases, disorders, or conditions such as pulmonary hypertension.

The intrauterine hemostasis balloon comprises a guiding assembly and a liquid injection assembly, the guiding assembly comprises a guiding head, a bulb and a flexible catheter, the guiding assembly is used for guiding the intrauterine hemostasis balloon, the guiding head is fixedly connected to the top end of the flexible catheter, and the bulb is fixedly connected to the liquid injection assembly. The guide head penetrates through the bulb and is fixedly connected with the outer surface of the bulb, the interior of the bulb is hollow, the flexible guide pipe penetrates through the bulb and is fixedly connected with the bulb, the liquid injection assembly is jointly composed of a first one-way valve, a sleeve, a piston rod, a liquid injection bag and a connecting pipe, and the liquid injection assembly is used for injecting liquid into the bulb. The first one-way valve is fixedly connected to the flexible guide pipe in series, and the sleeve is connected with the piston rod in a sleeved mode. According to the device, the guide head is arranged, so that the uterus of a puerpera cannot be scratched when the device is used, and the problem that the uterus of the puerpera is stimulated due to scraping is solved.

The disclosure relates to a combination of biomarkers comprising at least: (i-a) one biomarker selected in each of the following group of biomarkers: Patient's age, Plasma steroids, and Urinary steroids, and at least one biomarker selected in at least one of the group of biomarkers: O-methylated catecholamines, Small metabolites, and miRNA; or (i-b) one biomarker selected in each of the following group of biomarkers: Plasma steroids, Urinary steroids, and Small metabolites, and at least one biomarker selected in at least one of the group of biomarkers: Patient's age, O-methylated catecholamines, and miRNA. The combinations of biomarkers may be used for stratifying a hypertensive patient among different hypertensive diseases comprising Endocrine Hypertension (EHT), Primary Aldosteronism (PA), Pheochromocytoma / Functional Paraganglioma (PPGL), Cushing's Syndrome (CS), and Primary Hypertension (PHT).

The invention provides a gestational hypertension dynamic risk assessment system based on PAGln, and relates to the technical field of health risk assessment. The system comprises a data processing module which is used for obtaining basic information of pregnant women in the early stage of pregnancy and physiological data including serum PAGln concentration, and constructing a combined feature set of the pregnant women in the early stage of pregnancy; the risk assessment module is used for generating a dynamic risk assessment result of the gestational hypertension disease by using the dynamic risk assessment model of the gestational hypertension disease; the result visualization module is used for visually displaying the dynamic risk assessment result of the gestational hypertension disease; and the personalized scheme generation module is used for making a personalized health management scheme according to the dynamic risk assessment result of the gestational hypertension disease of the pregnant woman in the early stage of pregnancy. The serum PAGln concentration is used as a core index for risk assessment of the gestational hypertension disease, high specificity can be kept, meanwhile, sensitivity can be remarkably improved, and risk early warning of the pregnant women in the early stage of pregnancy is achieved.

A wearable electronic system for the multi-modal monitoring and early detection of pre-eclampsia is disclosed. The system comprises a wristworn computing platform and a wirelessly coupled abdominal sensor unit. The wrist-worn device integrates a full-color touchscreen display (16); a rotary encoder (22) employing a Hall-effect sensor and a conductive crown surface (27) functioning as an ECG reference electrode; and a biometric sensor cluster comprising a four-photodiode optical array (17), a multi-wavelength LED array (21), a SioZ / ECG electrode assembly (19), and a skin-surface temperature sensor (18), all interfaced to a unified analog front-end (30). A central multi-core microcontroller unit (28), supported by high-bandwidth PSRAM (37) and NOR-Flash (29), orchestrates real-time signal processing for cuffless blood pressure estimation. A hardware security module (45) ensures hardware-rooted encryption of all maternal and fetal biometric data. The abdominal sensor utilizes a piezoelectric transducer and microphone to capture fetal heart rate and uterine contractions, enabling consolidated clinical-grade surveillance and automated risk classification for hypertensive disorders during pregnancy.