69 results about "HYPERTENSIVE DISEASES" patented technology

The invention discloses a preparation method for metoprolol salt, which includes the steps of utilizing p-(2-methoxyethyl) phenol and epoxy chloropropane as raw materials and water or ethanol as dissolvent, and obtaining 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane under the action of strong alkali; and utilizing water as dissolvent, carrying reaction between the 3-[4-(2-methoxyethyl phenoxy)]-1,2-epoxypropane and isopropylamine so that metoprolol alkali is obtained, and then carrying out reaction between the metoprolol alkali and saturated monohydric alcohol liquor of organic acid or saturated monohydric alcohol liquor of hydrochloric acid, so that the metoprolol salt is obtained. Clinically, hydrochloride, succinate, fumarate or tartrate of the compound is utilized as common medicinefor treating hypertensive disease, coronary disease, congestive heart failure and arrhythmia. The raw materials of the preparation method are cheap and easy to obtain, the water and the ethanol are utilized as the dissolvent so as to hardly cause pollution, the method is convenient in operation, high in purity of the prepared metoprolol salt, high in yield, lower in cost and extremely suitable for mass production.

Disclosed herein is the treatment of vision loss in a mammal by transplanting an effective amount of hNT-Neuron cells. The treatment can be accomplished by injecting the cells into the retinal area of the eye. Additionally, the cells can be injected into the visual cortex of the brain. Conditions to be treated are vision loss due to optic nerve damage, including glaucoma, optic nerve sheath meningioma and glioma, Graves' ophthalmopathy, benign or malignant orbital tumors, metastatic lesions, tumors arising from the adjacent paranasal sinuses or middle cranial fossa, giant pituitary adenomas, brain tumors or abscesses, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, pseudotumor cerebri, cavernous sinus thrombosis, dural sinus thrombosis, encephalitis, space-occupying brain lesions, severe hypertensive disease or pulmonary emphysema.

The present invention relates to a chewing gum comprising functional ingredients of mulberry leaves, which allows high absorption of the functional ingredients of mulberry leaves, and a method for the preparation of the chewing gum. This chewing gum containing functional ingredients of mulberry leaves includes: 15-30% (w/w) gum base, 60-80% (w/w) sugar alcohol, 0.1-0.5% (w/w) tenderizer, 0.1 -1.0% (w/w) humectant, 0.1-0.5% (w/w) emulsifier, 0.5-2.5% (w/w) flavoring agent, 0.01-10.0% (w/w) functional ingredients of mulberry leaves and 0.1-2.0% (w/w) fruit juice concentrate. This chewing gum containing functional ingredients of mulberry leaves can be practically applied to prescribed food and food replacement for patients suffering from constipation, diabetes and hypertension.

The invention relates to a device for detecting blood pressure data. The device comprises a blood pressure measuring unit with an air pump, an inflatable cuff and a pressure sensor, wherein the pressure sensor is connected with a computer processing unit through an A/D conversion interface; the computer processing unit comprises a central processing unit CPU for operation, a memorizer, a communication interface and a human-computer interface; the computer processing unit is also connected with a pickup for acquiring voice of a user and a voice module for processing an audio frequency signal acquired by the pickup and converting the audio frequency signal into a digital signal; and the communication interface of the computer processing unit is connected with a data communication module for sending the blood pressure data and voice data to a network server. A doctor can make more accurate diagnosis according to a curve which is generated by the blood pressure data of multiple measurements and voice description of the user; and the device is expected to greatly improve the capabilities of diagnosing and controlling hypertensive disease.

The invention discloses a healthcare and nutrition ostrich egg liquid, which is mainly used for preventing and treating a hypertensive disease, and belongs to the fields of prevention and health protection of traditional Chinese medicines. The healthcare and nutrition ostrich egg liquid disclosed by the invention is prepared from the following components: ostrich eggs, semen coicis, mature vinegar, astragalus membranaceus, peach kernel, flowers carthami, angelica sinensis tail, ligusticum wallichii, radix paeoniae rubra, earthworm, hawthorn, rhizoma alismatis, polygonum multiflorum, radix rehmanniae recen, semen cassiae and liquorice. The healthcare and nutrition ostrich egg liquid has the efficacies of benefiting qi, nourishing blood, promoting blood circulation to remove blood stasis, relieving pain, nourishing the blood to expel wind, warming and activating meridians and reducing phlegm; the effective rate is 90%; the recovery rate is 80%; the average cure time needs three treatment courses (one month as one treatment course); the cure time for patients with serious conditions needs 0.5-1 year; and the healthcare and nutrition ostrich egg liquid can be scientifically taken according to the requirements, and has a relatively good market development prospect.

The present invention relates to a Chinese patent medicine for curing hypertensive disease, including the components of salvia miltiorrhiza, Herba Cephalanoploris, herba gynostemae, cassia seed, ginkgo biloba, common selfheal, hawkthorn, honey and dogbane leaf. Herba Cephalanoploris and hawkthorn are cleaned and decontaminated, then milled and filtered after dipping in water, and the drug liquid is for standby; danshen, herba gynostemae, ginkgo biloba, common selfheal, dogbane leaf and cassia seed are cleaned and decontaminated, decocted for twice and filter; the filtrate mixed with the drug liquid and added with honey is decompressed and condensed to 1/3 of the original volume; the drug liquid is placed until the temperature decreases to less than 40 DEG C and then added with ethanol for 24-hour settlement; the supernatant is filtered so as to recover ethanol. pH value is adjusted to 5.5 to 6.5 and water is added to 10,000ml. After shaking, standing, filtering, filling and sterilizing, the Chinese patent medicine is obtained. According to clinical observation, the present invention has the effect of reducing hypertension and hyperlipemia, softening blood vessels, and seeking both temporary and permanent solutions.

The invention discloses a traditional Chinese medicine composition capable of reducing the blood pressure and tonifying the kidney and a preparation method and application thereof. The traditional Chinese medicine composition is prepared with the following raw materials in parts by weight: 30-100 parts of sticktight, 10-30 parts of radix polygoni multiflori preparata and 3-15 parts of dogwood. In the preparation method, the traditional Chinese medicine ratio and formula of the traditional Chinese medicine composition provided by the invention are determined based on syndrome differentiation and treatment in accordance with the theory of traditional Chinese medicine, and the results of pharmacological experiments show that the traditional Chinese medicine composition provided by the invention has a good function of reducing the blood pressure with lasting stable effect and no recurrence, improving the biochemical indicators of the blood of patients with high blood pressure, basically preventing and treating hypertensive diseases, obviously preventing the hypertension-induced nephropathy and protecting the kidney. Moreover, the dosage of the traditional Chinese medicine composition provided by the invention is small, and no adverse reaction occurs in the experiment. Therefore, the traditional Chinese medicine composition can be used for treatment of hypertensive diseases and complications of hypertensive diseases and renal diseases.

The invention discloses a hear comforting and brain clearing traditional Chinese medicine composition. The purpose is to provide a Chinese medicine preparation which can improve the capacity of the cardiac muscles, has a cardiotonic effect, accelerate blood circulation, restrain thrombosis, regulate blood lipids, blood sugar and blood pressure, boost immunity, strengthen the spleen and nourish the stomach. The Chinese medicine preparation for treating the hypertensive disease comprises, by weight, the following raw materials: 6-10 pars of pseudo-ginseng, 15-30 parts of roots of red-rooted salvia, 10-15 parts of astragali radixes, 5-10 parts of gastrodia elata, 10-15 parts of chrysanthemum, 5-10 parts of ligusticum wallichii and 10-15 parts of seeds of wild jujubes.

The invention discloses an establishing method of a hypertensive disorder complicating pregnancy mouse model. The establishing method of the hypertensive disorder complicating pregnancy mouse model comprises the following steps of: extracting a syncytiotrophoblast microvilli membrane; and inputting the syncytiotrophoblast microvilli membrane to a pregnant mouse body of the same strain by caudal vein injection to establish the hypertensive disorder complicating pregnancy mouse model. The hypertensive disorder complicating pregnancy mouse model established by the establishing method disclosed by the invention has hypertensive disorder complicating pregnancy characteristic symptoms and signs including elevation of blood pressure, eclampsia hyperspasmia, damages to heart and liver and the like, which are consistent with the symptoms and pathological process of the hypertensive disorder complicating pregnancy including eclampsia and the like at the early stage of the human eclampsia, and therefore, the hypertensive disorder complicating pregnancy mouse model can be used for researching the occurrence and development mechanism of the hypertensive disorder complicating pregnancy including eclampsia and the like at the early stage of the eclampsia, as well as the medical foundation with the purpose of developing antagonistic medicaments and the clinical research.

The invention discloses a novel application of a traditional Chinese medicine extract product-Arctigenin in preparation of anti-arrhythmia medicines. A research found that the Arctigenin has bidirectional anti-arrhythmia effect and can adjust arrhythmia caused by aconitine and ouabain. Arctigenin has an effect for reducing ventricular muscle contraction force. A pharmacological effect of the Arctigenin is bidirectional adjusted cardiac muscle cell inner calcium current, the cardiac muscle cell inner potassium current is increased, and the sodium current is inhibited. The invention shows that the Arctigenin has anti-arrhythmia effect, and especially has bidirectional adjusting on arrhythmia, the side-effect is smaller, the Arctigenin has application prospect for treating toxic arrhythmia and ischemic-reperfusion arrhythmia in aconitine and ouabain; and the Arctigenin with myocardial contractility reduction effect can be taken as an auxiliary treatment measurement for hypertensive disease.

The invention relates to an underwear fabric manufacturing process, which mainly comprises the steps of weaving and post-treatment and is innovatively characterized in that firstly gauze is woven; 23-30 parts of semen cassiae, 19-29 parts of raw sophora flower, 21-26 parts of kudzuvine root, 19-26 parts of tender uncaria, 23-29 parts of Scutellaria baicalensis, 28-36 parts of hawthorn, 29-34 parts of earthworm and 21-24 parts of fructus evodiae by weight are added into a pressure container, and temperature is increased to 60-78 DEG C and is kept constant for 120-140 minutes; and then post-treatment is conducted. Since semen cassiae, raw sophora flower, kudzuvine root, tender uncaria, Scutellaria baicalensis, hawthorn, earthworm, fructus evodiae and the like are added in the gauze, the medical efficacies can be slowly exerted when people wear the underwear for long time, the efficacies of the traditional Chinese medicine are respectively exerted, the effects of reducing blood pressure and reducing cholesterol are obtained, certain auxiliary curative effects of preventing and curing angiosclerosis and hypertensive diseases are obtained, the effect of reducing liver Yang exuberance syndrome hypertension is more remarkable, healthcare and treatment can be conducted during sleeping and the living needs of modern senile people are met.

Relating to the technical field of screening and application of aptamers, the invention provides an aptamer with xanthine oxidase inhibitory activity and application thereof. The DNA molecule of a nucleotide sequence of the aptamer is: TGCCTTACGTGGGCCTA TGCGTGCTACCGTGAAAG or a complementary sequence thereof, the aptamer with xanthine oxidase inhibitory activity is obtained through screening by combining magnetic bead-SELEX with capillary electrophoresis-SELEX technology, and can be applied to preparation of xanthine oxidase inhibitors or uric acid-lowering drugs. The invention overcomes the defects in the prior art, the aptamer has remarkable xanthine oxidase inhibition activity and uric acid reduction activity, can be used as a health care product and a drug lead compound for diseases like gout, hyperuricemia, coronary atherosclerotic heart disease, chronic heart failure, myocardial infarction, hypertensive disease, etc., and has good application prospects.

The invention discloses water-soluble yam residue diet fiber coffee milk, solving the problems that people who have three-high and constipation diseases are difficult to choose commercially available coffee milk. The water-soluble yam residue diet fiber coffee milk provided by the invention can alleviate constipation, keep the metabolic balance of human bodies, and prevent and treat the diseases such as diabetes, hypertensive disease, hyperlipidemia and high cholesterol, and is beneficial for human health.

The invention relates to application of an SGLT2 inhibitor in combination with an ARB to preparation of a medicament for treating hypertensive disease and other diseases. Specifically, the SGLT2 inhibitor is selected from a compound (1) or a complex thereof or a medicinal salt thereof or a stereisomer thereof; the angiotensin II receptor antagonist (ARB) is selected from losartan, valsartan, irbesartan, candesartan, tasosartan, azilsartan, eprosartan, olmesartan or telmisartan. The general formula of the compound (1) is shown in the description.

The invention discloses a sensor array device for measuring pulse waves. A sensor array is designed such that 3-5 sensors in the sensor array placed on the arterial vessel sense blood pressure signalsin the arteries being tested. A pulse wave signal processing and construction method lowers noise to a maximum content by using the correlation between adjacent sensors in the sensor array, and enhances the pulse wave signals to a maximum content by using the position difference between the sensors and the arteries in the sensor array. The device accurately measures pulse wave signals, and is ofgreat significance and application prospect for the prevention and rehabilitation of cardiovascular and hypertensive diseases.

The invention provides a traditional Chinese and western medicine dialectical typing system for hypertension, and the system comprises a data collection module which is used for collecting a normal biochemical index data set and an abnormal biochemical index data set; the traditional Chinese and western medicine combination module is used for performing traditional Chinese medicine typing on the patients with hypertension diseases to obtain a biochemical index data set corresponding to typing; the data fusion module is used for fusing the normal biochemical index data set, the abnormal biochemical index data set and the biochemical index data set corresponding to the typing by adopting an Apriori algorithm to obtain a fused data set; the typing model construction module is used for constructing an LDA topic model, performing parameter optimization on the LDA topic model, and training to generate a traditional Chinese and western medicine dialectical typing model; and the dialectical typing module is used for acquiring biochemical index data of the current hypertension patient and inputting the biochemical index data into the traditional Chinese and western medicine dialectical typing model for dialectical typing. According to the invention, the western medicine conventional examination data and the traditional Chinese medicine theory are combined, so that the accuracy of hypertension dialectical typing is improved.

The invention discloses a quantitative salt bottle which comprises a bottle body, a bottle cap, a cap plate, a bottle cap sliding plate, a first scraping plate and a second scraping plate. The upper end of the bottle body is connected with the bottle cap. The bottle cap is internally provided with an opening. The cap plate is arranged above the opening. A salt outlet is formed above the cap plate. The slidable bottle cap sliding plate is arranged above the salt outlet. One side of the salt outlet is provided with the first scraping plate and the second scraping plate which are oppositely fixed to the lower end of the cap plate. The cap plate is in a triangular shape. The bottle cap sliding plate is movably arranged on the cap plate through a bottle cap sliding groove in the cap plate. The quantitative salt bottle is simple in structure and practical, people take out proper amount of salt just through the first scraping plate, the second scraping plate and a slat spoon matched with the first scraping plate and the second scraping plate when using salt, the weight of daily edible salt is calculated conveniently for people, and it is avoided that the hypertensive disease, nephropathy and other serious diseases are caused due to the fact that salt is eaten excessively, so that the purpose of healthy diet is achieved, and the using requirement of people is met.

The invention relates to a method for extracting medicine for treating human cardiovascular diseases from thalictrum robustum. The method comprises the following steps that thalictrum robustum is subjected to ultrasonic extraction and cation exchange resin desorption, wherein the solvent of the ultrasonic extraction is ethanol, the ultrasonic frequency is 25 to 35 kHz, the cation exchange resin desorption adopts sodium hydroxide water solution, and hydrochloric acid is adopted for desorption in desorption solution. According to the method, through ultrasonic extraction and cation exchange resin active ingredient adsorption, the finally obtained extracts can be used for effectively preventing and treating hypertensive diseases. The method has the advantages that the steps are simple, the influence on the activity of active ingredients is small, and the active ingredients of the extracts cannot be weakened, Compared with the existing extracting method, the method obtains the outstanding progress.

The invention relates to a Cannabis-based pharmaceutical composition for the treatment of hypertensive disorders by submucosal delivery comprising a pharmaceutically acceptable base and an effective amount of at least one cannabinoid or endocannabinoid containing extract of a cloned hybrid of the plant Cannabis sativa, subspecies sativa and Cannabis sativa, subspecies indica of the CTSX-ISS lineage; and methods of treatment of primary and secondary hypertension, the secondary hypertension resulting from pheochromocytoma, primary hyperaldosteronism, adrenal hyperplasia, pulmonary hypertension, portal hypertension, folate deficiency hypertension, arterial hypertension or familial hypertension by administration between one and eight times per day.

The invention provides a walnut oil-containing seal oil soft capsule mainly comprising the effective constituents: seal oil [containing EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), DPA (docosapentaenoic acid) and squalene], walnut oil and phosphatidylcholine. Main auxiliary materials comprise water, vitamin E, glycerinum and edible animal gelatin. By utilizing the walnut oil-containing seal oil soft capsule, cholesterol and fat in blood can be effectively reduced, blood viscosity can be effectively reduced, blood vessel can be effectively softened and expanded, diseases of artery blood vessel induration, thrombus, and the like can be effectively prevented, and the walnut oil-containing seal oil soft capsule has the effects of nourishing brain, improving memory and preventing hypertensive disease.

The invention relates to new technology for evaluating efficacy of antihypertensive traditional Chinese medicines (TCMs). The effect of the antihypertensive TCMs on improving microcirculation is evaluated through measurement of microvessel blood flow and the curative effects of the TCMs on treating hypertensive diseases and improving prognosis of the complications are further evaluated. The microvessel blood flow can be rapidly, intuitively and effectively measured by measuring the microvessel blood flow volume with a speckle full-frame real-time scanning imaging system in a non-contact and nondestructive manner and generating color images corresponding to measured areas in different perfusions. The new technology can be widely applicable to microcirculation of body surface parts of human bodies and common experimental animals and provides a more valuable basis for comprehensively evaluating the efficacy of the antihypertensive medicines.