1758results about "Dispersion delivery" patented technology

The invention discloses a macrophage-targeting inhalable nano material, a preparation method thereof and application of the inhalable nano material in treatment of sepsis myocarditis, and belongs to the technical field of medicines. The nano-material is a nano-liposome, the nano-liposome comprises a mannose modified nano-liposome microsphere, and the mannose modified nano-liposome microsphere comprises a liposome skeleton shell layer, a drug and a targeting layer; the liposome skeleton shell layer comprises soybean lecithin and cholesterol; the medicine comprises quercetin and TPPU (Thermoplastic Polyurethane); and the targeting layer is formed by connecting mannose modified DSPE-PEG2000 to the outer surface of the liposome skeleton shell layer. The nano material can accurately target macrophages at a cardiac inflammation part, has a multi-target-point synergistic effect, is more convenient and faster in administration, remarkably improves the safety and comprehensively improves the treatment effect.

The present invention provides, among other things, improved pharmaceutical compositions comprising codon-optimized mRNA encoding a peptide or polypeptide encapsulated in a lipid nanoparticle comprising one or more of the cationic lipids that are particularly effective for pulmonary delivery.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating meniere disease membrane hydrolost and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: rhizoma alismatis, rhizoma atractylodis macrocephalae, poria cocos, gastrodia elata, ginger processed pinellia, pericarpium citri reticulatae and fresh ginger. The traditional Chinese medicine composition disclosed by the invention is small in dosage and special in effect, and dialectical compatibility is performed according to the phlegm-dampness theory of traditional Chinese medicine, combined with the pathological basis of the meniere disease and based on the treatment rules of transforming fluid retention, inducing diuresis, tonifying spleen and calming liver, so that the aim of treating both symptoms and root causes is achieved. Animal experiments prove that the traditional Chinese medicine composition can obviously relieve the cochlear hydrops degree of a rat with membranous hydrolost.

The present invention relates to the pharmaceutical composition comprising Zonisamide and one or more pharmaceutically acceptable excipients and also relates to the process for the preparation of the pharmaceutical composition comprising Zonisamide.

Methods to edit genes by administering a chimeric nuclease to a cell or organism without the use of a viral vector.

The present invention relates to a composition comprising a compound represented by general formula (1), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, and a surfactant. [wherein R1, P1, R2, P3, P4, R5, P6, R10, P10 and P11 are C1 to C6 alkyl or the like; R3 and P9 are hydrogen or the like; R7 is phenethyl optionally substituted by halogen or the like; R8 forms a 4-to 7-membered saturated heterocyclic ring together with a carbon atom bonded to P8 and R8 and a nitrogen atom bonded to P8; R9 forms a 3- to 8-membered alicyclic ring together with Q9 and a carbon atom bonded to R9 and Q9; and R11 is di-C1 to C6 alkylaminocarbonyl or the like].

A method of generating an emulsion for treating a patient. The method includes generating a water-based solution carrying an agent which turns into a hydrogel by addition of calcium ions. Radium radionuclides are added to the water-based solution in a concentration sufficient for radiotherapy. After adding the radium to the water-based solution, the water-based solution is mixed with an emulsifier and an oil.

The invention provides application of qi-blood foundation strengthening oral liquid in preparation of a medicine for building body and resisting aging, and belongs to the technical field of medicine preparations. According to the invention, the mass ratio relationship among the components and the preparation method thereof are researched, and especially in the preparation process, the traditional Chinese medicine components are extracted by adopting the modes of high-pressure steam heating, vacuum concentration and the like under different pressures in batches and stages, so that the obtained oral liquid for consolidating qi and blood not only has the effective component content, but also has the health-care effect. The oral liquid for consolidating qi and blood has the effects of improving the activity of superoxide dismutase of red blood cells and reducing the content of lipofuscin in tissues, can improve the exercise tolerance of rats, and has the effects of resisting aging and building the body.

Disclosed herein are methods to edit genes, for example by administering a chimeric nuclease to a cell or organism without the use of a viral vector. Some methods herein include editing DNA of a cell by contacting the cell with a nuclease comprising a Cas9 sequence, where the nuclease edits the DNA of the cell.

The invention includes methods of preventing or treating acute lung injury using a MAP3K2 / MAP3K3 inhibitor. The invention further comprises compositions, and kits comprising compositions useful within the invention.

The embodiment of the invention provides a traditional Chinese medicine preparation for improving lung qi and yin deficiency constitution and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials: 1-3 parts of American ginseng, 2-15 parts of Chinese yam, 1.5-9 parts of codonopsis pilosula, 1-6 parts of dendrobium officinale, 1.5-9 parts of rhizoma polygonati, 0.5-2 parts of schisandra chinensis, 2-6 parts of lily, 1-3 parts of pericarpium citri reticulatae, 1-2 parts of liquorice, 1-5 parts of folium mori, 1-3 parts of donkey-hide gelatin, 1-3 parts of mint, 1-6 parts of angelica sinensis and 2-9 parts of coix seeds. Therefore, the traditional Chinese medicine composition has the functions of tonifying qi and yin, clearing heat and moistening lung, replenishing blood and promoting salivation, and relieving cough and reducing sputum, and can be widely applied to chronic cough, various pneumonia, pulmonary tuberculosis, chronic obstructive pulmonary disease, lung malignant tumor, asthma remission period of asthma, respiratory failure and other syndrome-differentiated lung qi and yin deficiency patients.

The invention relates to pharmaceutical compositions comprising one or more benzodiazepine drugs for nasal administration, methods for producing and for using such compositions.

The invention provides application of qi and blood strengthening oral liquid in preparation of a medicine for improving hyperlipidemia, and belongs to the technical field of medicine preparations. According to the invention, the mass ratio relationship among the components and the preparation method thereof are researched, and especially in the preparation process, the traditional Chinese medicine components are extracted by means of high-pressure steam heating, vacuum concentration and the like under different pressures in batches and stages, so that the obtained oral liquid for consolidating qi and blood is high in content of effective components, and has a good effect on consolidating qi and blood. The oral liquid for consolidating qi and blood can significantly improve hyperlipidemia, and has potential clinical application value.

Introduced here is a face mask system having a mask enclosure that contains, or otherwise directly supports, an automated liquid-droplet dispensing mechanism (ADM) for humidification. In operation, the enclosure and ADM are compact and lightweight so that when worn by a user can be supported entirely by the user's head and neck. The enclosure can be comprised of one or more layers of breathable fabric adapted to flexibly conform to the face of a user when worn and form a cavity that is adjacent to the user's nostrils and mouth. The ADM can be comprised of a reservoir in which liquid is stored, a respiratory cycle detector, a timer and controller, and a droplet dispenser that controllably dispenses droplets of the liquid from the reservoir into the cavity for inhalation by the user.

The invention discloses a targeted slow-release curcumin compound with an auxiliary liver protection function and a preparation method thereof.The preparation method comprises the steps that whey protein isolate is heated under the acidic condition to prepare whey protein isolate fibers, and then the whey protein isolate fibers are compounded with kappa-carrageenan; adjusting the mixed system to be alkaline by adopting a pH migration method, adding a curcumin alkaline solution, fully dissolving the curcumin alkaline solution, and combining the curcumin alkaline solution with the whey protein isolate fiber-kappa-carrageenan composite system; and adjusting the pH value of the system back to be neutral to obtain the high-load amorphous curcumin solution and the solid preparation. The whey fiber and the kappa-carrageenan are self-assembled in the pH circulation process to form a composite carrier, curcumin is converted into an amorphous state from a crystalline state, the solubility of curcumin is remarkably improved, the loading capacity is greatly improved to 70% at most, the heat stability, oxidation resistance and biological accessibility of curcumin are improved, targeted slow release of curcumin can be achieved, and the curcumin-targeted slow release preparation has a good application prospect. The positioning release performance of the curcumin in the intestinal tract part is improved, and the application form of the curcumin in liver protection function products is expanded.

A system and method for enhanced aerosol drug delivery during high flow nasal cannula (HFNC) therapy. The system comprises a breath enhanced jet nebulizer (BEJN) connected to a high flow medical breathing gas supply supplying breathing gas to the BEJN at flow rates of 5 L / min to 60 L / min, a nebulization gas supply, a drug infusion device that supplies a drug solution to the nebulizer for the delivery of nebulized drug to a patient. All the breathing gas and nebulized drug solution delivered to the patient passes through the BEJN. The rate of drug delivery increases with increases in the flow rate of the medical breathing gas supply and increases in infusion pump flow rates. The drug solution infusion rate is between 5 mL / hour and 50 mL / hour. This system and method enable efficient aerosol drug delivery to patients during HFNC therapy for prolonged periods, improving treatment outcomes.

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

Provided are pharmaceutical formulations comprising a recombinant acid α-glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa; at least one buffer selected from the group consisting of a citrate, a phosphate and combinations thereof; and at least one excipient selected from the group consisting of mannitol, polysorbate 80, and combinations thereof, wherein the formulation has a pH of from about 5.0 to about 7.0. Also provided are methods of treating Pompe disease using these pharmaceutical formulations.

The invention discloses a cane molasses extract with a blood sugar reducing effect as well as a preparation method and application thereof, and belongs to the field of functional foods. According to the invention, cane molasses is subjected to dissolution, centrifugation, ultrafiltration impurity removal, desalination and nanofiltration concentration, and is mixed with calcium chloride, so that the cane molasses extract with the effect of reducing blood sugar is prepared. Experimental results prove that the cane molasses extract prepared by the invention has the characteristics of low glycemic index (GI), carbohydrate digestive enzyme inhibition, high temperature resistance, long-term storage resistance and the like, can also effectively repair pancreas and liver injury and regulate intestinal flora, and has a comprehensive hypoglycemic effect. The food with low glycemic index is prepared on the basis of the high sucrose carrier for the first time, and the food has sweet taste and the function of reducing blood sugar. The invention provides a new raw material scheme for the preparation of dietary supplement food and hypoglycemic drugs for hyperglycemia people, and has prominent practical application value and wide application prospect.

Oral pharmaceutical solution comprising a pharmaceutically acceptable salt of lisdexamfetamine, and a pharmaceutically acceptable aqueous carrier comprising a buffer and a cosolvent selected from the group consisting of a glycol, a polyol, and a mixture thereof, wherein the pH of the solution is from 5.5 to 9.0. The oral pharmaceutical solution presents excellent physicochemical stability, even under alkaline conditions.

The invention discloses a low-temperature cold-extraction slow-distillation extraction system and method for honeysuckle juice, and relates to the technical field of honeysuckle juice extraction. A vacuum slow distillation stage; a low-temperature purification stage; a fermentation stage and a blending stage; according to the method, low-temperature cold extraction is combined with vacuum gradient slow distillation, degradation of heat-sensitive components such as chlorogenic acid and galuteolin is effectively reduced, and the retention rate of the heat-sensitive components is greatly increased; components with different boiling points are collected by stages through gradient distillation, the extraction rate of functional components such as polysaccharide and flavone is increased, and the problem of component loss caused by a traditional high-temperature process is solved. Low-temperature treatment retains more natural aroma substances, gradient distillation makes the aroma level of the product richer, and the flavor is better than that of the original process; the filtration and alcohol precipitation treatment in the low-temperature purification stage significantly improves the clarity qualification rate of the finished product, and ensures the appearance quality of the product. Distillation residues and mother liquor filter residues are fermented by bacillus subtilis to produce enzyme primary pulp, the comprehensive utilization rate of raw materials is greatly increased, and resource circulation is achieved.

Disclosed is a pharmaceutical composition for inhalation comprising salbutamol or enantiomer or salt or ester thereof and a pharmaceutically acceptable green propellant. Particularly, disclosed is a pharmaceutical composition for inhalation comprising salbutamol or enantiomer or salt or ester thereof and a pharmaceutically acceptable green propellant HFA-152a and / or HFO-1234ze(E). Also disclosed processes of preparing such compositions.

The present disclosure provides pharmaceutical and nutritional compositions and methods for treating mitochondrial disorders. The present invention relates to a pharmaceutical or nutritional composition comprising a stabilized sulforaphene (e.g., a sulforaphene-cyclodextrin complex) that improves the efficacy, biological activity, and stability of the isolated sulforaphene. The disclosure also includes the use of the stabilized sulforaphene as an effective therapeutic agent for the treatment of mitochondrial disorders, such as mitochondrial myopathy.

The invention belongs to the technical field of biological medicine, and particularly relates to a reagent for improving ovarian development and a preparation method and application thereof. The reagent for improving ovarian development is prepared by mixing the following raw materials in parts by weight: 20-30 parts of N-acetylcysteine; 5 to 10 parts of tranexamic acid; 3 to 8 parts of creatine; and 3000 parts of water. According to the reagent, the mRNA expression of PKD1P6 and follicle stimulating hormone receptors (FSHR) in ovarian tissues is up-regulated, the activity and functions of cumulus granular cells are enhanced, and apoptosis of the cumulus granular cells is inhibited, so that the effects of effectively promoting follicle development and inhibiting the apoptosis of the cumulus granular cells are achieved.

The invention discloses a traditional Chinese medicine compound preparation for treating insomnia and a preparation method thereof, the traditional Chinese medicine compound preparation is prepared from the following raw materials or alcohol and water of the following raw materials or water extract or honey-processed paste: 15-30g of lily, 15-30g of lucid ganoderma, 15-90g of vine of multiflower knotweed, 30-60g of cortex albiziae, 30-60g of nacre mother of pearl, 6-15g of coptis chinensis, 15-30g of spina date seed, 30-60g of poria with hostwood, 6-15g of polygala tenuifolia and 30-60g of magnetite. The preparation method comprises the following steps: uniformly mixing 30-60 g of lapis chloriti, 30-60 g of ligusticum wallichii, 10-15 g of schisandra chinensis, 3-10 g of cinnamon, 15-30 g of salvia miltiorrhiza, 30-60 g of oyster, 15-30 g of platycladi seed, 15-30 g of corydalis tuber and 15-30 g of rhizoma anemarrhenae with alcohol or water or refining honey to prepare paste, and preparing the paste into a required dosage form. The traditional Chinese medicine composition has the beneficial effects that after scientific and reasonable compatibility and preparation, the medicine effect has a synergistic effect, and the traditional Chinese medicine composition has the effects of nourishing yin, clearing heat, calming the heart and soothing the nerves and is used for treating insomnia caused by fire excess from yin deficiency and liver depression.

The present invention relates to a method for subjecting a subject to an augmented reality (AR) or virtual reality (VR) experience. The method may comprise administering to the subject a composition comprising a cannabinoid compound. The method may comprise, subsequent to the administration of the composition comprising the cannabinoid compound, using an AR or VR device to subject the subject to an AR or VR experience. The method may comprise detecting a response of the subject to the AR or VR experience and the composition comprising the cannabinoid compound.

The application discloses a mucous membrane adhesion auxiliary material and a lipid material with mucous membrane adhesion prepared by using the auxiliary material, the nanoparticle has mucous membrane adhesion and can be adhered to the surface of a mucous membrane and is suitable for mucous membrane administration. The lipid nanoparticle promotes the entry of the lipid nanoparticle into cells by forming a disulfide bond with the sulfydryl on the surface of mucous membrane cells, and the entry of the lipid nanoparticle into cells is a non-endosome-lysosome pathway, so that the encapsulated nucleic acid macromolecule can be avoided from being degraded by enzymes in cells, thereby directly delivering the macromolecular nucleic acid in the cytoplasm to play a role.

The disclosure provides for methods and compositions for treating respiratory obstructive diseases.

The present invention relates to formulations comprising dolutegravir or a pharmaceutically acceptable salt thereof, methods for making such formulations, and the use of such formulations in the treatment of HIV infection, particularly in the treatment of HIV infection in pediatric patients.