The present invention includes compositions and methods for the treatment and prevention of oral mucosal disorders and for promotion of
bone health. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-
diindolylmethane (DIM), or a DIM-related indole, alone or in combination with anti-inflammatory agents and / or antibacterial agents, to treat oral mucosal disorders and promote
bone health. The compositions of the invention are used to prevent and reverse oral mucosal disorders and bone loss (
osteopenia and
osteoporosis) associated with aging and chronic
inflammation. Oral mucosal disorders include
Periodontitis,
gingivitis and related oral
mucosal inflammation. Formulations of the compositions of the invention include capsules, tablets, toothpastes, oral gels, mouthwashes, mouth rinses, lozenges,
chewing gum,
dental floss, and dental topical formulations, and fortified foods.