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2 results about "Diindolylmethane" patented technology
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A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1 active clinical trials or http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1&closed=1 closed clinical trials using this agent. (http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53434 NCI Thesaurus)
Composition comprising 3,3'-diindolylmethane and perilla oil and its use for the treatment of diseases associated with impaired appetite regulation
The present application relates to a composition consisting of 3,3'-diindolylmethane and perilla oil, wherein the perilla oil comprises an amount of from about 50% to about 70% of α-linolenic acid (ALA) by weight, relative to the total weight of fatty acids in the perilla oil.
Owner:QUEEN MARY UNIV OF LONDON
An engineered stem cell nanocaspaosome, and a preparation method and application thereof
PendingCN122146591ASkeletal/connective tissue cellsArtificial cell constructsApoptosis inductionGrowth cycle
The present application relates to a kind of engineered stem cell nanometer apoptotic bodies, its preparation method includes the following steps: by 3,3'-diindolylmethane directional induction obtains the engineered stem cell rich in repair and anti-inflammatory signal molecules, and then the engineered stem cell is induced to apoptosis, and the supernatant is separated and obtained by collection, then the programmed tandem extrusion process is handled to the engineered apoptotic body, and the particle size uniformity of the engineered nanometer apoptotic body is prepared.The engineered nanometer apoptotic body of the present application can effectively improve the microenvironment around hair follicle and regulate hair growth cycle, significantly improve the hair density and regeneration rate of androgenetic alopecia model mice, provide a new strategy of safe, convenient and efficient for clinical hair regeneration treatment.
Owner:CHINA PHARM UNIV