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10 results about "Diindolylmethane" patented technology
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A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1 active clinical trials or http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=462587&idtype=1&closed=1 closed clinical trials using this agent. (http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C53434 NCI Thesaurus)
Topical dim compositions and cosmetic uses thereof
Described herein are topical compositions for cosmetic use in a subject in need thereof, wherein the composition comprises emulsified substituted or unsubstituted diindolylmethane and a pharmaceutically acceptable carrier, and wherein the composition does not cause irritation or allergic reaction after topical application. In addition, methods are provided for improving the dermal bioavailability of substituted or unsubstituted diindolylmethane through topical administration, relative to other route of administration such as oral administration.
Owner:IIAA
Stem cell-derived engineered nano-vesicle for promoting hair growth and preparation method of stem cell-derived engineered nano-vesicle
PendingCN121991890AEffective intakeimprove protectionSkeletal/connective tissue cellsUnknown materialsAndrogenHair follicle stem
The invention relates to stem cell-derived engineered nano-vesicles (e-NVs) for promoting hair growth, the engineered nano-vesicles are prepared from stem cells through engineering induction, apoptosis induction and programmed serial extrusion processes in sequence, and an inducer used for engineering induction is 3, 3 '-diindolylmethane. The particle size of the engineered nano vesicle is mainly distributed in a range of 50-300 nm, the polydispersity coefficient is 0.05-0.20, and the expression proportion of phosphatidylserine is 40%-50%. The rice vesicles can effectively improve the hair follicle microenvironment, adjust the hair growth cycle, promote proliferation and differentiation of hair follicle stem cells and remarkably increase the hair regeneration rate of androgenetic alopecia model mice, and a safe, convenient and efficient clinical strategy is provided for hair regeneration treatment.
Owner:NANJING SAILIKANG BIOMEDICAL TECHNOLOGY CO LTD
Composition comprising 3,3'-diindolylmethane and perilla oil and its use for the treatment of diseases associated with impaired appetite regulation
The present application relates to a composition consisting of 3,3'-diindolylmethane and perilla oil, wherein the perilla oil comprises an amount of from about 50% to about 70% of α-linolenic acid (ALA) by weight, relative to the total weight of fatty acids in the perilla oil.
Owner:QUEEN MARY UNIV OF LONDON
Composition comprising a diindolylmethane and a retinoid to treat a skin condition
ActiveUS12527765B2Hydroxy compound active ingredientsPharmaceutical delivery mechanismRetinoidBiochemistry
Provided is a composition for use in treating a skin condition, the composition comprising:(a) a first component comprising a substituted or unsubstituted diindolylmethane compound; and(b) a second component comprising a substituted or unsubstituted retinoid compound.
Owner:SKINTECH LIFE SCI LTD
S-hydroxychloroquine, optionally with tauroursodeoxycholic acid and / or 3,3'-diindolylmethane, for treating and / or preventing neurological disorders
PCT designated stageWO2025213007A1Organic active ingredientsNervous disorderCholic acidHydroxychloroquine
A subject is administered an amount of an active agent effective to treat and / or prevent a neurological disorder, wherein the active agent comprises S-hydroxychloroquine with an enantiomeric excess of at least 20% of the S-enantiomer of hydroxychloroquine. The active agent may further comprise tauroursodeoxycholic acid and / or 3,3'-diindolylmethane. The subject may be diagnosed with a neurological disorder or may be identified as being at risk of developing a neurological disorder. Administering the active agent may at least partially normalize an aberrant level of an indicator characteristic of the neurological disorder.
Owner:THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH & HUMAN SERVICES
Composition for maintaining ovary and delaying ovary senescence and application thereof
The invention discloses a composition for maintaining ovaries and delaying ovarian aging. The composition is prepared from the following components in parts by weight: 0.1 to 15 parts of folic acid, 1 to 60 parts of ergothioneine, 50 to 1000 parts of fruit and vegetable powder, 30 to 500 parts of diindolylmethane and 50 to 2000 parts of inositol. The invention also discloses an application of the composition in preparation of products for maintaining ovary and delaying ovary senescence, and a dietary supplement or nourishment for maintaining ovary and delaying ovary senescence, which contains the composition and food-acceptable auxiliary materials. The composition and the dietary supplement or nourishment containing the composition can improve the ovarian hypofunction, such as premature ovarian failure and hypoovarian function, protect the health of women, and are safe, non-irritant and free of side effects.
Owner:SHENZHEN YUANLINGZHIJI BIOTECHNOLOGY CO LTD
An engineered stem cell nanocaspaosome, and a preparation method and application thereof
PendingCN122146591ASkeletal/connective tissue cellsArtificial cell constructsApoptosis inductionGrowth cycle
The present application relates to a kind of engineered stem cell nanometer apoptotic bodies, its preparation method includes the following steps: by 3,3'-diindolylmethane directional induction obtains the engineered stem cell rich in repair and anti-inflammatory signal molecules, and then the engineered stem cell is induced to apoptosis, and the supernatant is separated and obtained by collection, then the programmed tandem extrusion process is handled to the engineered apoptotic body, and the particle size uniformity of the engineered nanometer apoptotic body is prepared.The engineered nanometer apoptotic body of the present application can effectively improve the microenvironment around hair follicle and regulate hair growth cycle, significantly improve the hair density and regeneration rate of androgenetic alopecia model mice, provide a new strategy of safe, convenient and efficient for clinical hair regeneration treatment.
Owner:CHINA PHARM UNIV
Methods of treating acute coronary syndrome using 3,3′-diindolylmethane
ActiveUS12527766B2Peptide/protein ingredientsHydroxy compound active ingredientsCoronary arteriesAcute thrombosis
Provided herein are methods of enhancing mechanical thrombectomy during endovascular therapy for acute thrombosis using 3,3′-diindolylmethane.
Owner:BOULDER BIOSCIENCE LLC
Methods for treating endometriosis
Methods of treating endometriosis through modulation of Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) activity including administration of an NR4A1 ligand to an individual in need thereof are described. In an embodiment, the compounds include methylene substituted diindolylmethanes.
Owner:TEXAS A&M UNIVERSITY
Sleep-improving agent
To provide a sleep improving agent useful for improving the amount of sleep and the quality of sleep.SOLUTION: The sleep improving agent contains at least one kind selected from metformin, 3,3' - diindolylmethane and their salts as an active ingredient.SELECTED DRAWING: None
Owner:KAO CORP