354 results about "Cataracts" patented technology

The invention relates to the technical field of intelligent medical treatment, and discloses a cataract surgery navigation control method based on multi-modal fusion, which comprises the following steps: carrying out lightweight preprocessing on an eye fundus image, ultrasonic probe data, a corneal topographic map and intraocular pressure parameters through an edge computing architecture, and constructing an efficient feature extraction network by adopting a knowledge distillation technology; self-adaptive feature fusion is realized based on an uncertainty quantification mechanism, real-time structure recognition is provided by utilizing an augmented reality technology, an intelligent navigation strategy is generated by pre-training a reinforcement learning model, an instrument control system with multilayer safety guarantee is established, and continuous optimization of the system is realized by adopting an online learning mechanism. According to the invention, the precision and safety of the operation are effectively improved, and an effective technical scheme is provided for intelligent navigation control of the cataract operation.

The invention provides a fundus image enhancement method based on adaptive fuzzy evaluation and frequency domain enhancement, and the method comprises the following steps: S1, obtaining cataract fundus image samples of different fuzzy levels, and constructing a training data set; s2, constructing an image adaptive enhancement model based on fuzzy evaluation, wherein the image adaptive enhancement model comprises a fuzzy evaluation module, a consistency keeping module and a frequency adaptive enhancement module; and S3, performing model training on the constructed image adaptive enhancement model by using the training data set to obtain a trained image adaptive enhancement model which is used for adaptive enhancement of the cataract eye fundus image. According to the method, the structural definition and color fidelity of the cataract blurred fundus image can be effectively improved, and the diagnosis availability and clinical value of the image are improved.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The invention relates to the technical field of medicines, and provides a lanosterol derivative as well as a preparation method and application thereof. The lanosterol derivative provided by the invention has a structural formula as shown in a formula I or a formula II. The lanosterol derivative provided by the invention has both fat solubility and water solubility, and can effectively permeate into a diseased region in a body, so that the medicinal availability is improved; results of the embodiment show that the solubility of the lanosterol derivative provided by the invention in water is obviously higher than that of lanosterol or 25-hydroxylanosterol, and the lanosterol derivative shows an obvious cataract treatment effect in animal in-vivo experiments and has a wide prospect in preparation of drugs for treating eye diseases or symptoms. # imgabs0 #

The invention discloses a Hepu pearl polypeptide Nacrein-LP20 for treating cataract and application of the Hepu pearl polypeptide Nacrein-LP20, and belongs to the technical field of biological medicine. The amino acid sequence of the gene is as shown in SEQ ID NO. 1. The active polypeptide Nacrein-LP20 provided by the invention has strong capability of removing DPPH free radicals and hydroxyl free radicals, and has a certain application value in the aspect of oxidation resistance. The active polypeptide Nacrein-LP20 provided by the invention has a remarkable protective effect on oxidative stress of human lens cells, can improve the cataract lesion of selenium rats, and has a certain application value in the aspect of cataract treatment.

The invention relates to the technical field of surgical robots, in particular to an RCM mechanism for cataract surgery and a corresponding surgical robotic.The RCM mechanism comprises a first active supporting rod, a second active supporting rod, a third active supporting rod and a fourth active supporting rod, the first end of the first active supporting rod is slidably arranged on a guide rail, the second active supporting rod comprises a telescopic part and a supporting rod part, and the second end of the telescopic part is hinged to a first base; the first end of the telescopic part is connected with the supporting rod part; the second end of the first driven supporting rod is connected with the first driving supporting rod through a sliding part, the first end of the supporting rod part is hinged to the first driven supporting rod, the second end of the second driven supporting rod is parallel to the first driven supporting rod, and the second end of the second driven supporting rod is hinged to the second end of the supporting rod part; the first end of the driven piece is hinged to the first end of the first driven supporting rod, and the second end of the driven piece is hinged to the first end of the second driven supporting rod; according to the surgical robot provided by the invention, the accuracy and safety of the surgery can be realized, and ophthalmologic surgeries such as cataract and the like can be carried out more quickly and noninvasively.

The invention belongs to the technical field of medicines, and particularly relates to a multi-effect composition containing ergothioneine, a preparation method of the multi-effect composition and application of the multi-effect composition in eye products. The multi-effect composition is prepared from ergothioneine, tromethamine and sodium hyaluronate according to the mass ratio of (0.5 to 10) to (1 to 5) to (0.5 to 3). According to the multi-effect composition containing the ergothioneine, the tromethamine in the composition can protect the stability of the ergothioneine under the conditions of illumination and high temperature; the ergosulfide can protect the activity of macromolecular sodium hyaluronate. The synergistic compatibility of the ergothioneine, the sodium hyaluronate and the tromethamine is utilized, so that the moisturizing effect and the eye protection effect of the composition can be remarkably improved. The ergothioneine-containing multi-effect composition provided by the invention has the effect of preventing cataract through specific components and proportions, and has the advantages of long-acting eye moistening and good stability.

Crystalline polymorphic lutein and cocrystal forms of lutein are disclosed. The new forms have enhanced bioavailability and stability, and may be used, for example, for topically delivering lutein to the eye for inhibiting or preventing cataracts, macular degeneration, and photooxidative damage to retinal pigment epithelium.

The invention discloses eye drops containing L-ergothioneine and a preparation method of the eye drops. The eye drops are prepared from the following components in parts by weight: 0.0015 to 15 parts of L-ergothioneine, 0.001 to 0.01 part of a bacteriostatic agent, 0.05 to 15 parts of a buffering agent and the balance of normal saline, and the pH value of the eye drops is 5.0 to 7.0. Experiments show that L-ergothioneine can prevent and reverse denaturation of crystalline lens protein, the prepared eye drops containing L-ergothioneine can prevent and reduce opacity of crystalline lens protein, and the prevention and treatment effects on cataract are better than those of existing eye drops.

The invention discloses a biconvex crystalline lens organ relying on stiffness-controllable hydrogel external directional induction as well as a construction method and application thereof. A crystalline lens organ model provided by the invention is jointly realized by virtue of stiffness-controllable hydrogel and a composite growth factor; and the pluripotent stem cells are rapidly and directionally induced into crystalline lens organs with high quality in vitro. According to the technical scheme, the method comprises the following steps: (1) directionally inducing and differentiating the pluripotent stem cells into primary ectoderm cell clusters; (2) preparing hydrogel with specific rigidity and carrying out surface cell adhesion treatment; (3) planting the primary ectoderm cells on the cleaned polyacrylamide hydrogel and inducing the primary ectoderm cells into a neural ectoderm cell cluster; and (4) inducing the neural ectoderm cells to directionally differentiate into mature crystalline lens organs. The three-dimensional lens organ-like model obtained by the method has a sphere-like biconvex morphology with a top surface and a bottom surface, is transparent and has structures such as capsule membranes, lens epithelial cells and lens fibrocytes, and the bottom surface is also wrapped by a complete lens capsule membrane. Compared with the prior art, the method realizes the formation of a complete capsule film on the bottom surface and a sphere-like form. The obtained crystalline lens organ can be used for research on crystalline lens embryonic development, research on cataract pathogenesis and research, development and screening of cataract drugs.

The utility model provides a composite vibration phacoemulsification needle and a cataract phacoemulsification instrument, which relates to the technical field of medical devices. The composite vibration phacoemulsification needle provided by the utility model includes: a needle body, a cutting groove penetrating the inner and outer side surfaces of the needle body is arranged on the side wall of the needle body, and the length direction of the cutting groove is consistent with the length direction of the needle body; the distal end of the cutting groove is connected to the distal end face of the needle body, and the groove side wall of the cutting groove and the connecting edge of the outer side surface of the needle body form a first blade structure. When the composite vibration phacoemulsification needle is working, the needle head will perform a composite axial and circumferential motion. When the needle head rotates, the first blade structure can play a cutting role, increase the overall sharpness of the needle head, increase the rotational cutting ability, and the first blade structure is hidden on the side wall, which increases safety.

The invention discloses a cataract fundus image automatic grading method based on semi-supervised learning, and belongs to the field of medical artificial intelligence. Characteristic parameters are extracted through multi-modal feature fusion of the eye fundus image of a patient, a semi-supervised learning neural network model is constructed, a pseudo-label training model is formed in combination with a small amount of labeled data and a large amount of unlabeled data, automatic classification of the eye fundus image of cataract is realized, and the problems of low manual classification efficiency and high labeled data acquisition cost are solved. In the preprocessing stage, texture and color multi-dimensional feature parameters of an image are extracted, and image data are obtained through dimension reduction. In the model construction stage, network training data of double convolution activation layers and double maximum pooling layers are adopted, and the model outputs all levels of probabilities to realize grading. The semi-supervised iterative training adopts a pseudo tag generation and model optimization alternating strategy, and a high-confidence sample expansion training set is screened. In the evaluation stage, the performance of the model is comprehensively measured by using multiple indexes and a visualization technology, and finally the model is deployed and applied to provide reliable support for clinical diagnosis.

The invention relates to the technical field of medical apparatus and instruments, and discloses an injection and suction handle sleeve cap for a polished capsular membrane in a cataract phacoemulsification surgery. The handle is detachably connected with the body; the injection and suction inlet is formed in the top end of the body; the filling opening is formed in the outer side wall of the body; the cleaning device is located in the body; the cleaning device comprises a cleaning brush, a cleaning seat, an inflatable airbag, an air pipe and a push column, a cleaning groove is formed in the outer side wall of the body, the cleaning seat is slidably connected to the interior of the cleaning groove, the cleaning brush is fixedly connected to the outer side wall of the cleaning seat, and the inflatable airbag is fixed to the interior of the cleaning groove; the sleeve cap body is detachably connected to the handle, hard damage of metal materials to eyes is avoided, attachments and chyloids are scraped and cleaned through the cleaning device, the situation that in a traditional operation, the attachments are extracted through an enhanced negative pressure system, and extraction rupture is caused to a capsular membrane due to too large negative pressure is avoided, and the operation efficiency is improved. And the safety performance of the operation is improved.

The invention discloses a dioptric scleroderma cataract dynamic intraocular pressure stable control ultrasonic emulsification system adaptive to a dual-channel operation, which comprises a host control unit, an ultrasonic emulsification handle, a perfusion and suction system, an intraocular pressure monitoring unit, a pressure balance module and a scleroderma fragmentation module, through cooperation of the intraocular pressure control module and the two-way operation type adaptive control module, a high-precision filling valve and a closed-loop suction pump are synchronously adjusted in real time according to anterior chamber built-in and external monitoring fusion data, and intraoperative intraocular pressure fluctuation is controlled within + / -2 mmHg; through pulse modulation and a self-adaptive negative pressure curve of the hardcore fragmentation enhancement module, the stability of the anterior chamber is ensured while the hardcore fragmentation efficiency is improved; fluid dynamics and energy parameters can be automatically optimized according to conventional incisions or micro incisions; according to the system, the anterior chamber stability problem in the high-difficulty cataract surgery is solved.

The invention discloses an application of an eyesight-improving twenty-five-ingredient pill in preparation of a medicine for preventing or treating cataract and complications thereof, the eyesight-improving twenty-five-ingredient pill has obvious effects of clearing heat, cooling blood, improving eyesight and the like, has a good curative effect on cataract, is safe in clinical use, has no influence on hematuria routine, heart and liver and kidney functions before and after medication, and is suitable for clinical application. No obvious adverse reaction is found.

The invention relates to the technical field of medical instruments, in particular to a pair of capsular scissors for cataract surgery, which comprises a first rod body, a second rod body, a first blade, a second blade, a connecting assembly, a first elastic sheet, a second elastic sheet, a rotating assembly and a telescopic assembly. Through cooperation of the connecting assembly and the rotating assembly, the force application angle during operation is changed, a cornea incision needing to be formed is reduced, subsequent patient recovery is facilitated, the situation that the cornea incision is enlarged due to vertical opening and closing of conventional capsulorhexis scissors is prevented, and the problem that capsulorhexis forceps are difficult to control the size and position of the capsulorhexis incision can be solved; compared with the prior art, the capsular membrane can be cut more accurately, the size is controllable, the cutting edge is smooth, follow-up patient recovery and surgical operation are facilitated, the operability when the cutting angle is reduced is ensured through the telescopic assembly and the elastic piece, the surgical accuracy is improved, and damage to intraocular tissue in the surgical process is prevented; and the safety and the effect of the operation are improved.

The invention relates to an exosome composition, application thereof and exosome eye drops, and relates to the technical field of pharmaceutical preparations, and the exosome composition is composed of a mesenchymal stem cell exosome and a rabdosia lingua extract in a weight ratio of (5-10): (13-21). The exosome composition is composed of the mesenchymal stem cell exosome and the rabdosia lophanthoides extract in a proper proportion, and the mesenchymal stem cell exosome and the rabdosia lophanthoides extract are matched for use, so that the exosome composition has an excellent treatment effect on cataract and can be applied to preparation of products such as eye drops and the like, and a new treatment means is provided for cataract patients. In addition, the exosome eye drops provided by the invention do not contain side-effect components such as preservatives and hormones, have no obvious irritation and can be used for a long time.

The invention provides application of D-pyroglutamic acid in preparation of a medicine for preventing and / or treating cataract, and belongs to the technical field of medicines. The invention discloses application of D-pyroglutamic acid in preparation of a medicine for preventing and / or treating cataract. Results of the invention show that the D-pyroglutamic acid can effectively inhibit aggregation of crystalline lens proteins. In addition, the D-pyroglutamic acid drug is low in cytotoxicity, directly acts on crystalline epithelial cells and can effectively inhibit damage to the crystalline epithelial cells. Therefore, the medical application of the D-pyroglutamic acid is expanded, and meanwhile, a new diagnosis and treatment strategy is provided for attack and prevention of cataract.

The invention discloses a posterior capsule polisher for cataract surgery, and relates to the technical field of ophthalmologic surgical instruments, the polisher comprises a handle body, the front end of the handle body is provided with a polishing part for polishing a posterior capsule, and the front end of the handle body is fixedly connected with a light guide part; a light guide assembly is arranged between the outer side of the light guide part and the outer side of the handle body, and the light guide assembly achieves light guide and illumination for intraoperative operation by extruding a piezoelectric crystal arranged in the light guide assembly. According to the capsular membrane polisher used after the cataract operation, medical staff can extrude the liquid storage soft bag by pressing the elastic pressing piece, when the liquid storage soft bag is extruded and deformed greatly, much perfusate flows out, when the liquid storage soft bag is deformed slightly, little perfusate flows out, and when extrusion is not conducted, the perfusate flows out according to the set normal outflow amount; and the outflow amount of perfusate can be adjusted according to needs through the elastic pressing sheet, so that the perfusate can be better perfused into the eyes.

The invention discloses a polypeptide for inhibiting and reversing pathological aggregation of human crystalline lens protein gamma D. According to the invention, alpha B-crystalline lens protein is cut into small peptides, and the capability of inhibiting and reversing pathological aggregation of crystalline lens protein is detected, so that the optimal polypeptide targeting the gamma D-crystalline lens P23T mutant protein is screened out. The polypeptide screened by the invention can significantly inhibit the aggregation of the gammaD-lens P23T mutant protein, and can reverse the aggregation of the gammaD-lens P23T mutant protein, which indicates that the polypeptide provided by the invention has a potential effect of treating cataract, and has a wide application prospect clinically.

A noninvasive ophthalmic formulation, comprising a chelator (such as EDTA and its salts), a transport enhancer (such as Methyl Sulfonyl Methane; MSM), a second permeation enhancer such as propylene glycol, a thickening agent such as hydroxyethyl cellulose (HEC) and a surfactant such as polysorbate 80, is provided. The novel combination of the ingredients unexpectedly and beneficially reduces symptoms associated with early-stage, age-related cataracts. Methods for treating cataracts with compositions of the invention and measurement of improved visual function by measuring contrast sensitivity (CS) are provided.

The invention discloses a continuous optical zoom slit-lamp microscope system and an inspection method and application thereof, and belongs to the technical field of ophthalmology medical equipment. The system is composed of a continuous zooming module, a light source module, a data processing module, a 3D imaging module and an AI identification module. The inspection method comprises the steps of equipment initialization and head position fixation of an inspected person, AI low-magnification (5 *) preliminary screening, adaptive lens high-magnification (40 *) fine observation, dynamic light source adjustment, three-dimensional data acquisition and cloud intelligent diagnosis. The method is applied to examination and intelligent diagnosis of eye diseases such as cataract. The problems that a traditional slit-lamp microscope is discontinuous in zooming, inconvenient to operate, lack of intelligent diagnosis and free of 3D stereoscopic display are solved, and the objective of the invention is to realize simple and convenient equipment operation, continuous examination process, intelligent diagnosis and stereoscopic display, facilitate collective teaching, significantly improve the diagnosis efficiency and accuracy of eye diseases such as cataract and the like, and improve the diagnosis efficiency and accuracy of eye diseases such as cataract and the like. And DICOM standard data cloud sharing and remote consultation are supported.

The invention relates to the technical field of medical rehabilitation, in particular to a postoperative visual rehabilitation training system and method for cataract, eyeball rotation information of a patient is acquired through an interaction information acquisition module and transmitted to an eye movement and visual function analysis module, and the eye movement analysis module analyzes interaction information to obtain eye rotation action information; the visual function analysis module maps the interaction information to a topological feature space by utilizing a topological spectrum mapping algorithm to generate a feature matrix, constructs a contrast sensitivity function and a rehabilitation trajectory prediction tensor and finally generates optimal training parameters, and the training prescription generation module generates the optimal training parameters according to a visual function analysis result, eye rotation action information and a last training result. According to the system, a topological spectrum mapping algorithm is introduced, high-precision analysis of eye movement data and multi-dimensional evaluation of visual functions are achieved, an accurate basis is provided for the personalized training scheme, and the visual rehabilitation effect of a patient after a cataract operation is effectively improved.

The present invention relates to the technical field of surgical robots, and particularly to an RCM mechanism and a corresponding surgical robot that can be used in cataract surgery, including: a first active support rod, the first end of which is slidably arranged on a guide rail; a second active support rod, which includes a telescopic part and a support rod part, the second end of the telescopic part is hinged to a first base, and the first end of the telescopic part is connected to the support rod part; a first driven support rod, the second end of which is connected to the first active support rod through a sliding part, and the first end of the support rod part is hinged to the first driven support rod; a second driven support rod parallel to the first driven support rod, the second end of which is hinged to the second end of the support rod part; a driven member parallel to the support rod part, the first end of which is hinged to the first end of the first driven support rod, and the second end of which is hinged to the first end of the second driven support rod. The surgical robot provided by the present invention can achieve the accuracy and safety of the surgery, and perform cataract and other ophthalmic surgeries more quickly and non-invasively.

Systems, devices and methods are provided that provide assistance in selecting appropriate interventions for treatment of disease and injury to the eye. Systems of the inventive concept provide cloud-based processing and storage of clinical and patient-specific data, which can provide treatment recommendations and projected outcomes to a practitioner using a local device. Systems, devices, and methods can generate interactive physiomechanical models of the eye of a specified individual, which are derived measurements of mechanical properties of structures of the eye. The physiomechanical model is interactive, and can be used to emulate the effects of one or more medical interventions in the eye in order to implement an optimized treatment plan for the individual.

The invention relates to a force and position mixed sensing and control system and method for cataract ophthalmologic surgery. The method comprises the steps that a first adjusting parameter is calculated according to position and posture change data, collected by a position and posture collecting module, of an eyeball position and posture at the first moment; acquiring an actually measured contact force at a first moment acquired by a force sensor; acquiring puncture depth data of the surgical instrument at a first moment based on a pose acquisition module; inputting the puncture depth data into a preset puncture force model to obtain a predicted contact force; operating parameters of an admittance controller are adjusted according to the force error value of the actually measured contact force and the predicted contact force; outputting a second adjustment parameter based on the admittance controller according to the actually measured contact force; and inputting the initial operation instruction, the first adjustment parameter and the second adjustment parameter into a preset instruction adjustment model to generate a target operation instruction at a second moment. The ophthalmic surgical robot can adapt to diversified surgical scenes with high precision and low interference, and meanwhile, the operation accuracy and smoothness of the ophthalmic surgical robot and the safety of the ophthalmic surgery are considered.

The invention discloses a lens anterior-posterior capsule polisher, which is characterized in that a cleaning part is communicated with a pipeline part to form an integrated instrument. One part of the surface of the cleaning part is provided with a frosted part, and the other part of the surface is provided with a plurality of through holes. The frosted part can polish the anterior lens capsule by utilizing friction force, residual lens cortex and epithelial cells are removed, the postoperative lens capsular bag contraction probability is reduced, and the stability of the intraocular lens and the postoperative vision durability are enhanced. The through hole is matched with the pipeline part, and when the free end of the pipeline part is connected with intraocular perfusate, the perfusate can be sprayed through the through hole in multiple angles and multiple directions to wash and polish the posterior capsule. Compared with a bald needle head used in an existing water polishing technology, the polisher is wider and more uniform in flushing, operation safety can be effectively improved, postoperative vision and visual quality are improved, and the occurrence rate of posterior cataract is reduced. By means of the design, front and rear capsule membranes are polished through a single instrument, frequent instrument replacement in an operation is avoided, operation steps are simplified, and the operation effect and safety are improved.

The invention provides an intelligent follow-up visit monitoring system after cataract operation, and relates to the technical field of image processing. The intelligent follow-up visit monitoring system after the cataract operation comprises an acquisition module used for acquiring a plurality of image samples after the cataract operation; the classification module is used for inputting the plurality of image samples into a pre-trained image classification model and outputting probability values of classification results of various complications after the cataract operation corresponding to the image samples; the determining module is used for determining the uncertain value of each image sample according to the probability value of the classification result of various complications after the cataract operation corresponding to each image sample; the screening module is used for screening out a target image sample according to the uncertain value of each image sample; and the training module is used for training an image classification model according to the target image sample and the labeling result of the target image sample, and the trained image classification model is used for assisting in determining a post-cataract follow-up visit scheme. The method can improve the follow-up visit efficiency after the cataract operation.

The invention relates to the technical field of artificial lenses, in particular to a modified artificial lens and a preparation method and application thereof. The modified intraocular lens is characterized in that a PHEMA-copolymer film-serine polymer intraocular lens is used as a carrier, and adriamycin is loaded on the surface of the carrier. The modified intraocular lens has good physical barrier and biological inhibition effects, can avoid accumulation of proteins and lipids in tears, can avoid generation of bacterial infection complications, can prevent adhesion of lens epithelial cells, can block DNA replication and transcription processes of the lens epithelial cells, can inhibit proliferation of the lens epithelial cells, and can improve the lens epithelial cell proliferation rate. The prepared nano-material can induce apoptosis of lens epithelial cells, has an excellent antibacterial effect and good biocompatibility, and can prevent the occurrence of posterior cataract.