293 results about "Cataracts" patented technology

The invention relates to the technical field of intelligent medical treatment, and discloses a cataract surgery navigation control method based on multi-modal fusion, which comprises the following steps: carrying out lightweight preprocessing on an eye fundus image, ultrasonic probe data, a corneal topographic map and intraocular pressure parameters through an edge computing architecture, and constructing an efficient feature extraction network by adopting a knowledge distillation technology; self-adaptive feature fusion is realized based on an uncertainty quantification mechanism, real-time structure recognition is provided by utilizing an augmented reality technology, an intelligent navigation strategy is generated by pre-training a reinforcement learning model, an instrument control system with multilayer safety guarantee is established, and continuous optimization of the system is realized by adopting an online learning mechanism. According to the invention, the precision and safety of the operation are effectively improved, and an effective technical scheme is provided for intelligent navigation control of the cataract operation.

The invention provides a fundus image enhancement method based on adaptive fuzzy evaluation and frequency domain enhancement, and the method comprises the following steps: S1, obtaining cataract fundus image samples of different fuzzy levels, and constructing a training data set; s2, constructing an image adaptive enhancement model based on fuzzy evaluation, wherein the image adaptive enhancement model comprises a fuzzy evaluation module, a consistency keeping module and a frequency adaptive enhancement module; and S3, performing model training on the constructed image adaptive enhancement model by using the training data set to obtain a trained image adaptive enhancement model which is used for adaptive enhancement of the cataract eye fundus image. According to the method, the structural definition and color fidelity of the cataract blurred fundus image can be effectively improved, and the diagnosis availability and clinical value of the image are improved.

The invention relates to the field of surgical robots, and particularly discloses an intraoperative risk assessment system for a cataract surgical robot, comprising: a patient biomechanical monitoring unit for collecting a contact force between an instrument and an eye tissue, and calculating an anterior chamber equivalent pressure value according to an axial force component of the contact force and a contact area between the instrument and a cornea; the patient optical imaging monitoring unit is used for collecting microstructure images of the cornea and the lens capsule and quantifying the energy release density of ultrasonic emulsification; the robot motion parameter monitoring unit is used for collecting joint motion resistance, instrument tail end three-dimensional coordinates, motion speed and attitude angle of the robot; the multi-mode joint reasoning unit is used for identifying a high-risk operation state when the contact force is higher than a first preset value and the energy release density is higher than a second preset value; by adopting the technical scheme of the invention, multi-dimensional real-time monitoring can be realized, and a dynamic risk prediction model can be established by fusing heterogeneous data through an intelligent algorithm.

The invention discloses a preparation method of eye drops for treating glaucoma, cataract and vitreous opacification. The eye drops comprise the following components: berberine, N-acetyl carnosine and lycium barbarum polysaccharide. The specific formula comprises the following components: 0.1%-0.5% of berberine, 1%-3% of N-acetyl carnosine and 0.5%-2% of lycium barbarum polysaccharide. The invention belongs to the technical field of ophthalmic pharmaceutical preparations, and solves the problems that in the prior art, glaucoma, cataract and vitreous opacity generally need to be separately taken, the research on compound preparations is less, and the components possibly interact with one another.

The invention belongs to the technical field of medicines, and particularly relates to a multi-effect composition containing ergothioneine, a preparation method of the multi-effect composition and application of the multi-effect composition in eye products. The multi-effect composition is prepared from ergothioneine, tromethamine and sodium hyaluronate according to the mass ratio of (0.5 to 10) to (1 to 5) to (0.5 to 3). According to the multi-effect composition containing the ergothioneine, the tromethamine in the composition can protect the stability of the ergothioneine under the conditions of illumination and high temperature; the ergosulfide can protect the activity of macromolecular sodium hyaluronate. The synergistic compatibility of the ergothioneine, the sodium hyaluronate and the tromethamine is utilized, so that the moisturizing effect and the eye protection effect of the composition can be remarkably improved. The ergothioneine-containing multi-effect composition provided by the invention has the effect of preventing cataract through specific components and proportions, and has the advantages of long-acting eye moistening and good stability.

The invention discloses a cataract fundus image automatic grading method based on semi-supervised learning, and belongs to the field of medical artificial intelligence. Characteristic parameters are extracted through multi-modal feature fusion of the eye fundus image of a patient, a semi-supervised learning neural network model is constructed, a pseudo-label training model is formed in combination with a small amount of labeled data and a large amount of unlabeled data, automatic classification of the eye fundus image of cataract is realized, and the problems of low manual classification efficiency and high labeled data acquisition cost are solved. In the preprocessing stage, texture and color multi-dimensional feature parameters of an image are extracted, and image data are obtained through dimension reduction. In the model construction stage, network training data of double convolution activation layers and double maximum pooling layers are adopted, and the model outputs all levels of probabilities to realize grading. The semi-supervised iterative training adopts a pseudo tag generation and model optimization alternating strategy, and a high-confidence sample expansion training set is screened. In the evaluation stage, the performance of the model is comprehensively measured by using multiple indexes and a visualization technology, and finally the model is deployed and applied to provide reliable support for clinical diagnosis.

The invention discloses a dioptric scleroderma cataract dynamic intraocular pressure stable control ultrasonic emulsification system adaptive to a dual-channel operation, which comprises a host control unit, an ultrasonic emulsification handle, a perfusion and suction system, an intraocular pressure monitoring unit, a pressure balance module and a scleroderma fragmentation module, through cooperation of the intraocular pressure control module and the two-way operation type adaptive control module, a high-precision filling valve and a closed-loop suction pump are synchronously adjusted in real time according to anterior chamber built-in and external monitoring fusion data, and intraoperative intraocular pressure fluctuation is controlled within + / -2 mmHg; through pulse modulation and a self-adaptive negative pressure curve of the hardcore fragmentation enhancement module, the stability of the anterior chamber is ensured while the hardcore fragmentation efficiency is improved; fluid dynamics and energy parameters can be automatically optimized according to conventional incisions or micro incisions; according to the system, the anterior chamber stability problem in the high-difficulty cataract surgery is solved.

The invention discloses an application of an eyesight-improving twenty-five-ingredient pill in preparation of a medicine for preventing or treating cataract and complications thereof, the eyesight-improving twenty-five-ingredient pill has obvious effects of clearing heat, cooling blood, improving eyesight and the like, has a good curative effect on cataract, is safe in clinical use, has no influence on hematuria routine, heart and liver and kidney functions before and after medication, and is suitable for clinical application. No obvious adverse reaction is found.

The invention provides application of D-pyroglutamic acid in preparation of a medicine for preventing and / or treating cataract, and belongs to the technical field of medicines. The invention discloses application of D-pyroglutamic acid in preparation of a medicine for preventing and / or treating cataract. Results of the invention show that the D-pyroglutamic acid can effectively inhibit aggregation of crystalline lens proteins. In addition, the D-pyroglutamic acid drug is low in cytotoxicity, directly acts on crystalline epithelial cells and can effectively inhibit damage to the crystalline epithelial cells. Therefore, the medical application of the D-pyroglutamic acid is expanded, and meanwhile, a new diagnosis and treatment strategy is provided for attack and prevention of cataract.

The invention discloses a posterior capsule polisher for cataract surgery, and relates to the technical field of ophthalmologic surgical instruments, the polisher comprises a handle body, the front end of the handle body is provided with a polishing part for polishing a posterior capsule, and the front end of the handle body is fixedly connected with a light guide part; a light guide assembly is arranged between the outer side of the light guide part and the outer side of the handle body, and the light guide assembly achieves light guide and illumination for intraoperative operation by extruding a piezoelectric crystal arranged in the light guide assembly. According to the capsular membrane polisher used after the cataract operation, medical staff can extrude the liquid storage soft bag by pressing the elastic pressing piece, when the liquid storage soft bag is extruded and deformed greatly, much perfusate flows out, when the liquid storage soft bag is deformed slightly, little perfusate flows out, and when extrusion is not conducted, the perfusate flows out according to the set normal outflow amount; and the outflow amount of perfusate can be adjusted according to needs through the elastic pressing sheet, so that the perfusate can be better perfused into the eyes.

A noninvasive ophthalmic formulation, comprising a chelator (such as EDTA and its salts), a transport enhancer (such as Methyl Sulfonyl Methane; MSM), a second permeation enhancer such as propylene glycol, a thickening agent such as hydroxyethyl cellulose (HEC) and a surfactant such as polysorbate 80, is provided. The novel combination of the ingredients unexpectedly and beneficially reduces symptoms associated with early-stage, age-related cataracts. Methods for treating cataracts with compositions of the invention and measurement of improved visual function by measuring contrast sensitivity (CS) are provided.

The invention discloses a continuous optical zoom slit-lamp microscope system and an inspection method and application thereof, and belongs to the technical field of ophthalmology medical equipment. The system is composed of a continuous zooming module, a light source module, a data processing module, a 3D imaging module and an AI identification module. The inspection method comprises the steps of equipment initialization and head position fixation of an inspected person, AI low-magnification (5 *) preliminary screening, adaptive lens high-magnification (40 *) fine observation, dynamic light source adjustment, three-dimensional data acquisition and cloud intelligent diagnosis. The method is applied to examination and intelligent diagnosis of eye diseases such as cataract. The problems that a traditional slit-lamp microscope is discontinuous in zooming, inconvenient to operate, lack of intelligent diagnosis and free of 3D stereoscopic display are solved, and the objective of the invention is to realize simple and convenient equipment operation, continuous examination process, intelligent diagnosis and stereoscopic display, facilitate collective teaching, significantly improve the diagnosis efficiency and accuracy of eye diseases such as cataract and the like, and improve the diagnosis efficiency and accuracy of eye diseases such as cataract and the like. And DICOM standard data cloud sharing and remote consultation are supported.

The invention relates to the technical field of medical rehabilitation, in particular to a postoperative visual rehabilitation training system and method for cataract, eyeball rotation information of a patient is acquired through an interaction information acquisition module and transmitted to an eye movement and visual function analysis module, and the eye movement analysis module analyzes interaction information to obtain eye rotation action information; the visual function analysis module maps the interaction information to a topological feature space by utilizing a topological spectrum mapping algorithm to generate a feature matrix, constructs a contrast sensitivity function and a rehabilitation trajectory prediction tensor and finally generates optimal training parameters, and the training prescription generation module generates the optimal training parameters according to a visual function analysis result, eye rotation action information and a last training result. According to the system, a topological spectrum mapping algorithm is introduced, high-precision analysis of eye movement data and multi-dimensional evaluation of visual functions are achieved, an accurate basis is provided for the personalized training scheme, and the visual rehabilitation effect of a patient after a cataract operation is effectively improved.

The present invention relates to the technical field of surgical robots, and particularly to an RCM mechanism and a corresponding surgical robot that can be used in cataract surgery, including: a first active support rod, the first end of which is slidably arranged on a guide rail; a second active support rod, which includes a telescopic part and a support rod part, the second end of the telescopic part is hinged to a first base, and the first end of the telescopic part is connected to the support rod part; a first driven support rod, the second end of which is connected to the first active support rod through a sliding part, and the first end of the support rod part is hinged to the first driven support rod; a second driven support rod parallel to the first driven support rod, the second end of which is hinged to the second end of the support rod part; a driven member parallel to the support rod part, the first end of which is hinged to the first end of the first driven support rod, and the second end of which is hinged to the first end of the second driven support rod. The surgical robot provided by the present invention can achieve the accuracy and safety of the surgery, and perform cataract and other ophthalmic surgeries more quickly and non-invasively.

Systems, devices and methods are provided that provide assistance in selecting appropriate interventions for treatment of disease and injury to the eye. Systems of the inventive concept provide cloud-based processing and storage of clinical and patient-specific data, which can provide treatment recommendations and projected outcomes to a practitioner using a local device. Systems, devices, and methods can generate interactive physiomechanical models of the eye of a specified individual, which are derived measurements of mechanical properties of structures of the eye. The physiomechanical model is interactive, and can be used to emulate the effects of one or more medical interventions in the eye in order to implement an optimized treatment plan for the individual.

The invention discloses a lens anterior-posterior capsule polisher, which is characterized in that a cleaning part is communicated with a pipeline part to form an integrated instrument. One part of the surface of the cleaning part is provided with a frosted part, and the other part of the surface is provided with a plurality of through holes. The frosted part can polish the anterior lens capsule by utilizing friction force, residual lens cortex and epithelial cells are removed, the postoperative lens capsular bag contraction probability is reduced, and the stability of the intraocular lens and the postoperative vision durability are enhanced. The through hole is matched with the pipeline part, and when the free end of the pipeline part is connected with intraocular perfusate, the perfusate can be sprayed through the through hole in multiple angles and multiple directions to wash and polish the posterior capsule. Compared with a bald needle head used in an existing water polishing technology, the polisher is wider and more uniform in flushing, operation safety can be effectively improved, postoperative vision and visual quality are improved, and the occurrence rate of posterior cataract is reduced. By means of the design, front and rear capsule membranes are polished through a single instrument, frequent instrument replacement in an operation is avoided, operation steps are simplified, and the operation effect and safety are improved.

The invention provides an intelligent follow-up visit monitoring system after cataract operation, and relates to the technical field of image processing. The intelligent follow-up visit monitoring system after the cataract operation comprises an acquisition module used for acquiring a plurality of image samples after the cataract operation; the classification module is used for inputting the plurality of image samples into a pre-trained image classification model and outputting probability values of classification results of various complications after the cataract operation corresponding to the image samples; the determining module is used for determining the uncertain value of each image sample according to the probability value of the classification result of various complications after the cataract operation corresponding to each image sample; the screening module is used for screening out a target image sample according to the uncertain value of each image sample; and the training module is used for training an image classification model according to the target image sample and the labeling result of the target image sample, and the trained image classification model is used for assisting in determining a post-cataract follow-up visit scheme. The method can improve the follow-up visit efficiency after the cataract operation.

The utility model discloses a capsulorhexis marker for cataract surgery, relates to the technical field of surgical instruments, solves the problems that an existing device is low in operation stability and low in operation accuracy, and adopts the following scheme that an electric telescopic rod A is fixedly installed on the top face of a base. Through the arrangement of an electric telescopic rod A, an air cylinder and an electric telescopic rod B, the electric telescopic rod A and the air cylinder can drive an outer ring sleeve to move up and down, so that the outer ring sleeve is aligned with the edge of the cornea, then the electric telescopic rod B drives an inner ring to move downwards, a little pressure is applied to the cornea, and through mechanical operation, the stability and safety are improved; meanwhile, through the arrangement of a display screen, a super-definition camera and an illuminating lamp, when the outer ring sleeve and the inner ring are in contact with the cornea, the illuminating lamp illuminates the eyes, the super-definition camera transmits images of the eyes to the display screen to be displayed, observation of medical staff is facilitated, and the operation precision is improved.

The application discloses an ophthalmic disease image classification system based on a big data model, which comprises a data set construction module, an image segmentation module and a model training module.The data set construction module is used for collecting eye images of patients with different ophthalmic diseases in an ophthalmic clinic and performing image marking processing to construct training and test data sets.The image segmentation module adopts YOLOv7 to perform image segmentation on the images taken by the smart phone to obtain eye images containing only the part below the eyebrows and above the zygomatic arch.The model training module adopts a five-fold cross-validation method to train the model on the images, and applies data enhancement technology, white balance adjustment and a transfer learning algorithm.The application relates to the technical field of ophthalmic disease image classification.The ophthalmic disease image classification system based on the big data model has high classification accuracy for diseases such as cataracts, keratitis and pterygium in the development stage test set and different clinical evaluation stages.

The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative. The present invention relates to an ophthalmic composition in the form of an aqueous solution containing levofloxacin or salt or derivative thereof and ketorolac or salt or derivative thereof, for use in a method for the treatment of conjunctivitis and for the prevention or treatment of inflammation or prevention of infection after cataract surgery in a subject, according to a dosage regimen that improves patient compliance and tolerability and enables the prevention and treatment of intermediate / antibiotic-resistant infections.

An arrangement applied to a simulator for surgical training in ophthalmology that is anatomically similar to the human eye, and has the purpose of training and qualification in ophthalmological surgical processes. An artificial cataract for use in simulators for surgical training in ophthalmology.

A method for collecting biometric measurement data of an eye on the basis of different measurement modalities, allowing for physiologically correct, representative, and robust biometric measurement data. In the method, the measurement data for individual measurement variables and the dynamic behavior of the eye are recorded continuously at the highest possible repetition rate over the measurement time. The individual phases of the dynamics of the eye which define the limits of the phase for stable vision are analyzed on the basis of the measurement values, and only the measurement data for the individual measurement variables are output which have been detected during the phase for stable vision. Although the proposed method is provided for collecting biometric measurement data in preparation for a cataract operation, the method can also be applied to other areas of ophthalmology to generate error-free measurement data or recordings of the eye.

A plug for aqueous humor drainage tubes, an implantation device, and a removal device include a plug body, which is a conical structure. The bottom surface of the conical plug body is provided with a connecting protrusion extending outward, and the bottom surface of the plug body is provided with a magnetic connection structure. The magnetic connection structure is fixedly connected to the bottom surface of the plug body. The bottom surface of the plug body is also provided with an expansion layer structure, which is connected to the bottom surface of the plug body and covers the magnetic connection structure. The end of the magnetic connection structure extends outside the expansion layer structure. The present invention temporarily blocks the aqueous humor drainage tube of a glaucoma drainage implant to reduce the deposition of lens fragments, viscoelastics, inflammatory substances, etc. in the drainage tube during surgery, thereby reducing the intraocular pressure fluctuation of glaucoma patients after cataract surgery and avoiding the failure of glaucoma drainage implant surgery.

There is provided a method for determining type of cataract by an electronic device. The method includes performing vision focus calibration for a user, determining central and peripheral regions of interest on a display of the electronic device based on fixated vision, performing a primary test for obtaining scores for the central and peripheral regions of interest, selecting at least one vision test mode based on the obtained score, and adapting at least one visual display parameter based on the obtained score and the selected at least one vision test mode. The method also includes determining a type of cataract from the selected at least one vision test mode, determining severity of the determined type of cataract, and providing the determined type of cataract and the determined severity with one or more recommendations to the user.

Provided is a polypeptide capable of dissolving protein aggregates. Also provided is a method of treating a phase separation associated diseases, such as phase separation associated visual disorders (e.g., cataracts) using the polypeptide provided herein.

The present invention provides a data processing method and system based on cataract detection. The method obtains historical data of users in different dimensions and trains an AI decision model based on the historical data in different dimensions; obtains data to be analyzed, inputs the data to be analyzed into the trained AI decision model, and outputs analysis results; wherein, in the process of training the AI decision model, an entropy flow roaming algorithm is used to continuously adjust the weights of data in different dimensions to optimize the performance of the model. Specifically, the entropy flow roaming algorithm optimizes weight distribution through an entropy flow potential function and a dynamic balance mechanism, can adaptively adjust the search range, and is more suitable for the complex characteristics of medical data, thereby ultimately improving the accuracy and reliability of data processing results based on cataract detection.

The application discloses an STM2457-PLGA nano drug, an artificial lens and a preparation method and application thereof, and relates to the technical field of biological medicine. The preparation method of the STM2457-PLGA nano drug comprises the following steps: preparing nano microspheres by injecting an oil phase comprising STM2457 and PLGA and a water phase comprising PVA into a microfluidic chip, and obtaining the STM2457-PLGA nano drug after freeze-drying of the nano microspheres, wherein the particle size of the STM2457-PLGA nano drug is 50-300 nm. The long-acting release of STM2457 carried by the surface-modified artificial lens is realized through the controlled release effect of the PLGA nano microspheres, and the slow-release period can cover the high-incidence period of postoperative complications of cataract surgery through process optimization, far exceeding the traditional short-term release system, and can continuously meet the long-term prevention and treatment needs after surgery, and effectively reduce the risk of complications such as after-cataract.

Devices and methods for replacing a human lens after cataract surgery. The device is an insert for the eye capsule and is formed of two or more rings that are connected to one another. A primary lens is affixed to the insert. A secondary add-in lens can be added to the insert in a subsequent surgery to correct, or further optimise, the optical results obtained with the initial surgery.

The invention aims at providing a device for facilitating cornea wetting in cataract surgery, and relates to the technical field of medical instruments, an infusion assembly and an eyelid opening assembly are installed on a support, a water dripping rod is installed on an eyelid opening device of the eyelid opening assembly, and a doctor does not need to hold the device for dripping water by hand; the control panel is arranged on the bracket, so that the running power of the infusion pump, the on-off of the infusion pump and the timing working time of the infusion pump can be controlled flexibly to control the water flow speed of the point water and the timing point water so as to ensure that the cornea is always in an ideal wet state; the distance between the eye speculum on the two sides of the fixed part and the eye speculum on the two sides of the movable part can be adjusted through stretching of the fixed telescopic rod of the fixed part, and therefore the distance between the upper eyelid and the lower eyelid is controlled. The distance between the eye speculum bodies on the two sides of the movable part can be further adjusted by rotating the side screw rods of the movable part, and therefore different opening space shapes are met; the distance between the eye speculum of the movable part and the eye speculum of the fixed part can be adjusted by rotating the movable screw rod, so that the size of the expanded space is adjusted.

Pharmaceutical compositions, methods for treating various issues of the eyes, and methods of preparing such compositions are described. These pharmaceutical compositions may be for treating glaucoma, in preparation of eye surgery, during eye surgery, various post-op care (e.g., after cataract surgery, laser eye surgery, and the like), for treating dry eyes, and / or for promoting eyelash growth. These pharmaceutical compositions may comprise such active ingredients (APIs) as: timolol, latanoprost, brimonidine tartrate, dorzolamide, moxifloxacin HCl, dexamethasone PO4, phenylephrine HCl, lidocaine HCl, ketorolac tromethamine, bromfenac, prednisolone PO4, gatifloxacin, amniotic cytokine extract (ACE), prostaglandin E2 (PGE2), and combinations thereof.