101 results about "Intraocular implant" patented technology

Some embodiments disclosed herein relate to devices and methods for controlling placement of intraocular implants within a patient's eye including but not limited to placement within or near the collector ducts of Schlemm's canal located behind the trabecular meshwork. In some embodiments, a handheld peristaltic rotor device having a compression element can be positioned on a corneal surface of the eye and rotated to create a peristaltic movement of blood in one or more episcleral veins to generate blood reflux within Schlemm's canal such that one or more collector ducts, or channels, of Schlemm's canal can be located. In some embodiments, an implant can be implanted near the identified location of the one or more collector ducts, or channels.

Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include at least two implants preloaded within a delivery device and configured to be implanted within the eye, a metering device configured to transfer energy to the implants for delivery at selected locations within the eye, wherein the metering device is configured to meter a variable amount of energy for each implant delivery event in the eye. The system can further include an injector mechanism configured to serially engage and drive each of the implants.

Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

Systems and methods for delivering multiple ocular implants to reduce intraocular pressure are disclosed. The ocular implants can be implanted at multiple sites within a single human eye without requiring removal of the delivery apparatus from the eye. A system for delivering multiple ocular implants can include a plurality of implants, an external housing, and an introducer assembly. The external housing can provide access to an implant singulation actuator and an implant delivery actuator. The introducer assembly can comprise an auto- retracting introducer portion. The delivery apparatus can include an infinite activation mechanism / portion and / or a manual singulation mechanism / portion.

The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.

Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.

A system for treating an eye comprising a tissue stored within a lumen of an elongated cannula, the tissue comprises scleral, amniotic membrane, or acellular biomatrix tissue and having an elongated form factor. Related devices, systems, and methods are provided.

Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.

The invention relates to a sustained release biodegradable ocular implant containing axitinib dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.

To ensure that the implant is securely fixed until deployment and to reduce the risk of introducing undesirable particulate matter into the patient, we provide an implant with improved retention within the needle of the delivery device, which reduces the risk of retention failure based on the delivery device. [Solution] A medical implant is disclosed. The medical implant has a body having a first end having a first cross-sectional dimension, a second end having a second cross-sectional dimension, and a tapered portion extending between the first and second ends. The first cross-sectional dimension is larger than the second cross-sectional dimension. In some embodiments, the body comprises multiple layers.

An insertion device for an ocular implant for regulating intraocular pressure includes a cannula having an internal space for receiving at least a portion of an ocular implant having a stent and an implant opening for inserting the ocular implant; a handle configured to be connected to the cannula and held by a surgeon; and a holder configured to be coupled to the handle and including a receiving portion configured to receive the stent of the ocular implant. The ocular implant insertion device appropriately fixes the stent inserted into the tube of the ocular implant in a manner attached to the insertion device, thereby preventing problems such as the stent coming out of the tube, the implant being separated from the insertion device by the stent, or the stent obscuring the surgeon's field of vision during implant implantation surgery.

An intraocular pressure measurement system comprising: an intraocular implant having a pressure sensor implantable in an eye, wherein the pressure sensor defines an optical cavity with a depth that varies based on an intraocular pressure of the eye; and an external reader device having a number of laser light sources configured to emit a plurality of beams and project an array of spots formed from the plurality of beams onto the pressure sensor, and a detector configured to receive a reflection of the array of spots off the pressure sensor that is used to measure the intraocular pressure of the eye.

An intraocular implant that includes several lasers to produce several laser beams, where each laser beam has a different color. The implant also includes a diffraction grating to diffract the laser beams into a combined laser beam onto a retina of an eye when the implant is inside the eye, and a micro-electro-mechanical system (MEMS) scanner to move the combined laser beam over an area of the retina when the implant is inside the eye.

A system for treating an eye comprising a tissue stored within a lumen of an elongated cannula, the tissue comprises scleral. amniotic membrane, or acellular biomatrix tissue and having an elongated form factor. Related devices, systems, and methods are provided.

An ocular implant adapted to be disposed within Schlemm's canal of a human eye with a body extending along a curved longitudinal central axis in a curvature plane, a first strut on one side of the implant and a second strut on an opposite side of the implant, the circumferential extent of the first strut with respect to the plane of curvature being greater than the circumferential extent of the second strut with respect to the plane of curvature. The invention also includes methods of using the implant.

Intraocular implants may include a corticosteroid and a biodegradable polymer associated with the corticosteroid to facilitate the release of the corticosteroid into an eye for a period of time. In some embodiments, ocular conditions, such as diabetic macular edema can be treated through administration of an intraocular implant including a corticosteroid and a biodegradable polymer associated with the corticosteroid to the eye of a human at a frequency of about once every six months to about once a year.

The present disclosure relates to intraocular implants for treating a condition of the eye, wherein the implant is configured to deliver a drug to the eye. The present disclosure also relates to methods of treating a condition of the eye by delivering a drug from intraocular implants to the posterior chamber (e.g., sulcus), iridocorneal angle, sclera, cornea, limbus, and vitreous.

The present invention discloses an intraocular implant delivery device, which includes a housing, a main control pull rod assembly, a slider assembly, a striking assembly, a needle retracting turntable and a needle pushing assembly. The main control pull rod assembly, the slider assembly, the striking assembly and the needle retracting turntable are all arranged inside the housing. A through hole is provided at the distal end of the housing, and the needle of the needle pushing assembly passes through the through hole and extends to the outside of the housing. Energy sources capable of selectively releasing energy are arranged on the main control pull rod assembly, the slider assembly and the striking assembly; the main control pull rod assembly is actuated by an operator through a button arranged on the housing, so that a spring drives the main control pull rod assembly to move axially; for the intraocular implant delivery device of the present invention, only one puncture is required to repeatedly deliver implants to the trabecular meshwork of a patient for multiple times, improving the efficiency of the implant surgery and enabling higher implant accuracy of the implants; the present invention can effectively overcome the problems of empty firing of implants or firing two implants at a time caused by low grasping accuracy of the needle pushing.

An apparatus for eye surgery may comprise a nozzle having a delivery lumen, an implant bay coupled to the nozzle, and an implant disposed in the implant bay. The implant may comprise an optic body, a leading haptic, and a trailing haptic. In some examples, the implant may be an intraocular lens. The apparatus may further comprise an actuator comprising a housing and a plunger disposed within the housing and a leading splay arm operable to splay the leading haptic within the implant bay. The plunger can be operable to advance the optic body from the implant bay to the delivery lumen after the leading splay arm straightens the leading haptic.

Systems and methods involving an intraocular implant with input and / or output electronics are described. In some embodiments, the system includes an intraocular lens having at least one optic operably coupled to a haptic, one or more input electronics on the haptic and / or the optic; and one or more output electronics on the haptic and / or the optic for receiving and / or transmitting data.

An intraocular implant, kit, and method are disclosed. In one configuration, the implant is a frame that is installable in the suprachoroidal space of the eye and has an arcuate elongated shape that promotes the drainage of aqueous humor through the suprachoroidal space when installed in the suprachoroidal space and is configured to take on an elastically recoverable shape. The frame has a first axial end and a second axial end with respect to the longitudinal axis of the elongated shape, and the arcuate elongated shape defines a channel. The channel has a first axial opening at the first axial end of the frame, a second axial opening at the second axial end of the frame, and a longitudinal opening that extends continuously from the first axial end to the second axial end of the frame.

The invention relates to a polymer with adjusted molar masses and hydrophilic-hydrophobic balance, suitable for forming a slip-resistant coating on the internal surface of at least one part of an intraocular implant delivery device. The invention also relates to the use of said polymer for coating the internal surface of one or more parts of an intraocular implant delivery device, the method for coating said surface, and an intraocular implant delivery device comprising at least one part whose internal surface is coated with said polymer.

The application provides an intraocular implant delivery device. The intraocular implant conveying device comprises a shell, an energy assembly and a transmitting assembly, the energy assembly comprises a triggering part and a pushing mechanism, the pushing mechanism comprises a lever and a first elastic part, the first elastic part is connected between the lever and the shell, and the lever is rotatably arranged relative to the shell; the transmitting assembly comprises an observation tube and a push tube, the observation tube extends out of the shell, the push tube is movably arranged on the observation tube, and the push tube is used for containing an implant; in the process that the trigger piece moves from the initial position to the final position, the trigger piece drives the lever to rotate in the forward direction to compress the first elastic piece, the head end of the push tube moves towards the interior of the shell, and the implant is separated from the push tube from the head end; when the trigger part is located at the final position, the lever is separated from the trigger part, the first elastic part extends to drive the lever to rotate reversely, the lever pushes the tail end of the push tube to move towards the outside of the shell, and the head end pushes the implant to a target position.

An intraocular implant and system comprising: an intraocular device coupled to an attachment mechanism operable to transition between a first configuration and a second configuration to secure the intraocular device to the eye; and a delivery device operable to deliver the intraocular device to the eye and manipulate the attachment mechanism to transition between the first configuration and the second configuration.

The present application provides an acesulfame implant which is stable, safe and can achieve at least 6 months of sustained release, can effectively treat various eye diseases including but not limited to glaucoma, cataract, retinal vein obstruction (RVO), uveitis, diabetic macular edema (DME) and age-related macular degeneration (wAMD and nAMD), etc., avoids repeated administration, reduces the formation of side effects, reduces the cost of drug use, and meets the high stability required by drug preparation in production, storage and transportation, has good application prospect, and meets the unmet clinical needs.

An intraocular implant device is provided. The implant device may include a dock and a removable lens device (RLD) shaped for positioning inside the lens chamber of the eye. The dock may include a first frame, a power supply, and a controller. The RLD may include a second frame, a projector, and an electromechanical lens array. The second frame may be configured to replaceably attach to the first frame, such that RLD is replaceably attached to the dock.

The invention relates to an intraocular implant (10) comprising: - a central body (12) generally hollow toroidal in shape and open towards the center of the central body (12), the central body (12) being configured to accommodate a secondary intraocular implant, in particular an intraocular lens; - at least two attachments (14) connected to the central body (12) and equally distributed around the central body (12) to allow attachment of the implant in the eye (1) of a patient, each attachment (14) comprising a proximal portion (14-1) relative to the central body (12) and a distal portion (14-2) relative to the central body (12), the proximal portion (14-1) being formed by an elastic loop attached to the central body (12) and the distal portion by an elastic anchoring element (14-2) comprising an elongated base (14-3) attached to the elastic loop (14-1) and an apex (14-4) oriented generally perpendicular to the base (14-3).Figure for the abbreviation: figure 3.

The present disclosure relates to the field of pharmaceutical compositions, ocular implants, and systems and methods for treating an ocular condition. In certain aspects, the disclosure provides ocular implant systems for treating post-operative inflammation. In certain aspects, the ocular implants taught herein are rapid release extended treatment implants.

The invention relates to a method and device for determining the size of a phakic corrective implant for correcting the vision of the eye (3) of a patient. On the basis of a horizontal section (6) of the anterior segment of the eye and an optical power Po, the size of a plurality of implants taken from a base Ii is determined (34), the image of the respective positions of these implants is geometrically simulated (35) on reconstructed curves s1, s2,...si of the section, then the value Vtsci of the theoretical vault without compression and the total theoretical compression CTi are calculated (37), the probability of obtaining a satisfactory vault between two threshold values S1 and S2 is calculated (42) by taking into consideration the cases of patients who have been operated for whom the respective differences between their Vtsci and vaults postoperatively for a given compression CTi have been calculated, and the implant size that has the highest probability between S1 and S2 is selected (43).

An ophthalmic prosthetic and method for correcting negative and positive dysphotopsia. The ophthalmic prosthetic comprises a peripheral light blocking implant member adapted to locate in a gap between an iris and an intraocular implant lens. The gap is between the anterior surface of the lens and the posterior portion of the iris. An opacity of the peripheral light blocking implant member is selectively positioned to block passage of light.