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Intraocular drug delivery

a technology of intraocular drug and eye, which is applied in the field of intraocular drug delivery, can solve the problems of large size of remaining silicone tube and plate, retinal damage and blindness, and conjunctival erode,

Active Publication Date: 2017-12-07
AQUESYS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes a method for deploying an intraocular implant or shunt without creating a scleral flap or conjunctival dissection. The outflow end of the shunt can be placed in various outflow regions, including the subconjunctival space, suprascleral space, intra-Tenon's space, choroidal and suprachoroidal space, intrascleral space, Schlemm's canal, vitreous space, episcleral vein, or the supraciliary space. This allows for easier placement of the shunt within the eye without causing significant trauma and without requiring a low gauge silicone tube or diffusion plate attached to the tube. The shunt can be inserted through the target outflow region and ejected from the needle such that an inflow end of the shunt resides in the anterior chamber of the eye and an outflow end of the needle resides in the target outflow region.

Problems solved by technology

Build-up of aqueous humor and resulting intraocular pressure may result in irreversible damage to the optic nerve and the retina, which may lead to irreversible retinal damage and blindness.
Some of the problems associated with this surgery include the necessity to cauterize to avoid significant bleeding and the large size of the remaining silicone tube and plate.
Due to the obtrusive nature of the silicone tube and plate, these can eventually cause the conjunctiva to erode, requiring a scleral graft to be placed over the silicone tube and plate.

Method used

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Embodiment Construction

[0029]In the following detailed description, numerous specific details are set forth to provide a full understanding of the subject technology. It should be understood that the subject technology may be practiced without some of these specific details. In other instances, well-known structures and techniques have not been shown in detail so as not to obscure the subject technology.

[0030]Further, while the present description sets forth specific details of various embodiments, it will be appreciated that the description is illustrative only and should not be construed in any way as limiting. Additionally, it is contemplated that although particular embodiments may be disclosed or shown in the context of ab externo procedures, such embodiments can be used in ab interno procedures. For example, although various ab externo approaches are discussed herein, any embodiment of the implant placement devices and methods described herein can be modified to provide an ab interno procedure (i.e....

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Abstract

An ab externo method of placing an intraocular implant into an eye can include advancing a needle, in which the implant is disposed, into the eye through conjunctiva and sclera of the eye. The implant can include a drug deliverable to the eye. The implant can thereafter be released to be anchored in the eye and elute the drug to the eye.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims the benefit of and priority to related U.S. Patent Provisional Application No. 62 / 344,899, filed on Jun. 2, 2016, the entirety of which is incorporated herein by reference.BACKGROUNDField[0002]The present disclosure generally relates to delivering an intraocular implant into an eye, and more specifically, to methods and devices for ab externo implantation of a drug-eluting intraocular implant or a shunt without the creation of a scleral slit or conjunctival dissection.Description of the Related Art[0003]Glaucoma is a disease of the eye that affects millions of people. Glaucoma is associated with an increase in intraocular pressure resulting either from a failure of a drainage system of an eye to adequately remove aqueous humor from an anterior chamber of the eye or overproduction of aqueous humor by a ciliary body in the eye. Build-up of aqueous humor and resulting intraocular pressure may result in irreversible da...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61F9/007A61K9/00A61L27/22A61F9/00A61L27/54A61L27/28
CPCA61F9/00781A61F9/0017A61K9/0051A61F2250/0068A61L27/54A61L27/222A61F2250/0067A61L27/28A61L2430/16A61F9/00736A61L2300/602
Inventor HORVATH, CHRISTOPHERROMODA, LASZLO O.
Owner AQUESYS INC
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