An intrauterine
system (100, 300, 400, 500, 600) is disclosed that includes a frame (102, 302, 402, 502, 602), a removal wire (218, 326, 436, 626), and at least one pharmaceutically
active agent. The frame has a first end (104, 304, 404, 504, 604), a second end (106, 306, 406, 506, 606), and a length L. The first end of the frame comprises a first locking portion (108, 308, 408, 508, 608), the second end of the frame comprises a second locking portion (110, 310, 410, 510, 610), the first locking portion and the second locking portion being arranged to form a lock (202, 312, 432). A removal wire is attached to the first end of the frame. The removal wire is configured to guide the first locking portion to the second locking portion. Further, a kit comprising the above intrauterine
system and an insert is disclosed.