309 results about "Uterine contraction" patented technology

A wireless fetal and maternal monitoring system includes a fetal sensor unit adapted to receive signals indicative of a fetal heartbeat, the sensor optionally utilizing a Doppler ultrasound sensor. A short-range transmission unit sends the signals indicative of fetal heartbeat to a gateway unit, either directly or via an auxiliary communications unit, in which case the electrical coupling between the short-range transmission unit and the auxiliary communications unit is via a wired connection. The system includes a contraction actuator actuatable upon a maternal uterine contraction, which optionally is a EMG sensor. A gateway device provides for data visualization and data securitization. The gateway device provides for remote transmission of information through a data communication network. A server adapted to receive the information from the gateway device serves to store and process the data, and an interface system to permits remote patient monitoring.

PCT No. PCT / SE97 / 01968 Sec. 371 Date Aug. 2, 1999 Sec. 102(e) Date Aug. 2, 1999 PCT Filed Nov. 21, 1997 PCT Pub. No. WO98 / 23636 PCT Pub. Date Jun. 4, 1998Heptapeptide analogues or pharmaceutically acceptable salts thereof consist of a hexapeptide moiety S and a C-terminal beta -aminoalcohol residue Z bound to the moiety S by an amide bond, wherein the beta -aminoalcohol Z is -NR-CH(Q)-CH2OH, Q is (CH2)n-NH-A is H or -C(=NH)NH2, and R is CH3 or C2H5, and the moiety S wherein H is a D-aromatic alpha -aminoacid and Y is an aliphatic alpha -aminoacid and have oxytocin antagonist activity. Also disclosed is: a method of their synthesis; pharmaceutical compositions containing these analogues; the synthesis of such compositions; a method of control of uterine contractions.

The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient:(wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z1 is -COR1, -CH=CH-COR1 etc.; Z2 is H, alkyl etc.; Z3 is single bond, alkylene; Z4 is SO2, CO; Z5 is alkyl, phenyl, heterocyclic ring etc.; R2 is CONR8, O, S, NZ6, Z7-alkylene, alkylene etc.; R3 is H, alkyl, halogen, CF3 etc.; R4 is H, (substituted) alkyl etc.; n, t is 1-4).The compounds of the formula (I) can bind to receptors of PGE2 and show antagonistic activity against the action thereof or agonistic activity. Therefore, they are considered to be useful as medicine for inhibition of uterine contraction, analgesics, antidiarrheals, sleep inducers, medicine for increase of vesical capacity or medicine for uterine contraction, cathartic, suppression of gastric acid secretion, antihypertensive or diuretic agents.

The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.

A system and method for detecting for and initiating contractions of a uterus of a human patient employs a sensor for sensing electrical activity of the uterus of the patient. Data from the sensed electrical activity is stored in memory. A processor accesses the stored data for analysis. Electrical energy is applied to the uterus to initiate a uterine contraction when the analyzed data fails to satisfy predetermined detection criteria.

(1) Prostaglandin (PG) E2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient, (2) carbocyclic sulfonamides represented by the compound of the formula (II): cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore, (4) PGE2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient. The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE2 agonists, because they bind onto PGE2 receptor and have an activity of antagonist or agonist against the action thereof.

A device (1) for staunching postpartum haemorrhage of the uterus (U). The device (1) comprises an inflatable internal balloon (2) having an inlet connected by a fitting (3) over a distal end (4) of a tubular conduit (5). The tubular conduit (5) has a proximal end (6) for connection to an inflation source for manually inflating the internal balloon (2). A non-return valve (8) is fitted in the conduit (5) at the proximal end (6). The device (1) has an inflatable external balloon (10) for indicating when the surface of the internal balloon (2) has engaged with the wall of the uterus (U). The external balloon (10) also acts as an indicator to indicate subsequent contraction of the uterus (U).

A system and apparatus for implementing a user interface for displaying uterine contraction information is provided. The graphical user interface displays first information conveying a rate of uterine contractions, the first information being derived at least in part on the basis of at least a portion of a contraction signal. The graphical user interface also displays, concurrently with the first information, second information conveying a threshold rate of uterine contractions. In specific examples of implementation, the graphical user interface is adapted for selectively causing an alarm event based at least in part on a rate of uterine contractions conveyed by the first information and the threshold rate of uterine contractions.

A parturient procedure monitor system is composed of three ultrasonic sensors with emitting-receiving function for measuring the cervix expansion and the position of infantile head, three receiving ultrasonic sensor, pressure sensor, Doppler ultrasonic probe, ultrasonic signal driving and demodulating unit, calculating processor, uterine contraction pressure detecting and converting unit, ultrasonic infantile cardiorhythm detecting-D / A converting-calculating unit, and background processing-displaying and printing unit. Its method is also disclosed.

A wireless fetal and maternal monitoring system includes a fetal sensor unit adapted to receive signals indicative of a fetal heartbeat, the sensor optionally utilizing a Doppler ultrasound sensor. A short-range transmission unit sends the signals indicative of fetal heartbeat to a gateway unit, either directly or via an auxiliary communications unit, in which case the electrical coupling between the short-range transmission unit and the auxiliary communications unit is via a wired connection. The system includes a contraction actuator actuatable upon a maternal uterine contraction, which optionally is a EMG sensor. A gateway device provides for data visualization and data securitization. The gateway device provides for remote transmission of information through a data communication network. A server adapted to receive the information from the gateway device serves to store and process the data, and an interface system to permits remote patient monitoring.

A method and equipment for monitoring the uterine contraction of mother and controlling the delivery process features that an abdominal electrode including method is used to sample all abdominal signals including the noisese, such as mother ECG, fetal ECG and electromagnetic interference, and AGC module is designed for suppressing said noises, and a digital signal processor is used as the core unit to eliminate mother ECG. Its advantages are high reliability, no damage, and less distortion.

A signal processing arrangement 130, a monitoring system 100, a signal processing method, a monitoring method of monitoring uterine contractions of a pregnant woman, and a computer program product are provided. The signal processing arrangement 130 receives an electrophysiological signal 116 representing uterine muscle activity of a pregnant woman at an input 132. A filter 136 generates a filtered electrohysterogram signal from the electrophysiological signal 116. The filter 136 allows the passage of spectral components between 0 and 3 Hz. A window function applicator 138 applies a window function to the filtered electrohysterogram signal to obtain an output waveform 146. The window function defines that samples of a time interval preceding the application of the window function need to be used The output waveform 146 simulates output data of tocodynamometer or an intra-uterine pressure catheter. The output waveform 146 is provided at an output 144 of the signal processing arrangement.

The present invention relates to solid oral formulations comprising a compound of formula (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1′-biphenyl-4-yl)carbonyl]pyrrolidin-3-one-O-methyloxime, and / or an active metabolite thereof, and the use of said formulations in the treatment and / or prevention of preterm labor, premature birth, dysmenorrhea and embryo implantation failure due to uterine contractions. The present invention is furthermore related to processes for their preparation.

A seamless, smart fetal monitoring garment and methods of using thereof. The system includes a knitted or interwoven garment having a multiplicity of conductive textile electrodes for sensing maternal and fetal electrical vital signals. The maternal and fetal electrical vital signals are selected from a group including maternal heart rate, fetal heart rate and electromyogram (EMG) activities including uterine activities. The method includes wearing the garment, acquiring electrical mixed common, maternal and fetal vital signals from surface region of a pregnant woman, using the plurality of textile electrodes, optimally weighted summing-up the acquired signals, analyzing the summed-up signals to thereby extract the maternal signal and the fetal signal, including determining their heart rates, and including detecting health hazards and in some embodiments, including detecting a uterine contraction sequence suggesting the need to be hospitalized for birth giving.

The invention discloses a biological feedback type delivery physical analgesia device. The biological feedback type delivery physical analgesia device comprises a maternal womb monitoring module, a hand hold type pressure sensor, an electrical stimulation wave group generator, an electrical stimulation wave group output module and a delivery analgesia work station. The maternal womb monitoring module is used for detecting maternal womb physical sign signals, the hand hold type pressure sensor is used for converting degrees of pain sensed by parturients into pressure values, the delivery analgesia work station is used for comprehensively analyzing output parameters of electrical stimulation wave groups according to uterine contraction pressure values and hand hole pressure values in the maternal womb physical sign signals, and the electrical stimulation wave group generator regulates and controls to generate electrical stimulation wave groups according to the output parameters and outputs the electrical stimulation wave groups to body surfaces of the parturients through the electrical stimulation wave group output module and electrodes. The invention is further provided with an output and display module used for interaction between operators and equipment. The biological feedback type delivery physical analgesia device can duly regulate and control electrical stimulation wave group output parameters, the electrical stimulation wave group signals comprehensively take sense of organisms on electrical stimulation pulses of different frequencies and wave forms.

Systems and related methods for treating postpartum hemorrhage through insertion of a flexible and expandable cryoballoon into the intrauterine cavity, inflating it to conform to the size and shape of the cavity, pressurizing it to apply pressure on damaged tissue and / or blood vessels that are bleeding, and filling it with a chilled fluid to provide numbing and blood coagulation. The cryoballoon can be coated with a drug or hormone to promote blood coagulation and / or uterine contractions to expedite the cessation of bleeding. In addition, cryoballoon can be coated with a topical anesthetic and / or antiseptic agent to numb and clean the damaged areas. Further, the cryoballoon can be fabricated of a biodegradable, bioerodeable or other biocompatible material so that it can be left in the intrauterine cavity for an extended period of time after insertion.

The invention relates to a process for producing a uterine contraction medicament which uses carbetocin as a main drug. The process comprises a synthesis process and a preparation process. The technical scheme of solid-phase synthesis comprises the following steps of: 1, carrying out deprotection by using amino resin as a vector; 2, connecting carboxyl of Fmoc-Gly-OH with amino of the resin to obtain Fmoc-Gly-amino resin; 3, carrying out solid-phase synthesis sequentially to form sequence residual protection amino acid; 4, removing side-chain protecting groups of cysteine; 5, connecting brombutyl acid onto sulfydryl of cysteine; 6, removing terminal amino Fmoc protection; 7, carrying out solid-phase cyclization; 8, cutting to obtain carbetocin crude peptides; and 9, refining to obtain a carbetocin pure product. The process has the characteristics of simple reaction operation, easy post treatment, high yield, low cost and the like. The invention also discloses a process for preparing a carbetocin freeze-dried powder injection which mainly comprises the following material compositions: carbetocin serving as the main drug, an excipient, a pH (potential of hydrogen) value regulator and water for injection. The powder injection has the advantages of high dispersion degree, high stability and the like.

A uterine activity monitoring device and method for monitoring uterine activity on a nearly continuous basis. The device may comprise a belt configured to fit around a pregnant patient's abdomen, with a plurality of, uterine contraction sensors. These sensors may be protruding contraction sensing buttons, disposed generally perpendicular to the patient's skin. In order to avoid signal distortions caused by patient movement, the belt will often have at least one ambient motion sensor configured to monitor non-uterine contraction movements and produce background movement signals. These ambient motion sensors may be accelerometers and stretch or pressure disposed generally parallel to the patient's skin. The device will have an onboard processor communicate wirelessly with a variety of external monitoring and management systems, such as wrist worn monitors, cell phones, and remote patient management websites.

This invention is an improved balloon catheter for cervical dilation. This catheter has a balloon that is passed through the cervix of a pregnant woman, and the balloon is then inflated with 100-120 ml of sterile water or normal saline. The improved disc shape of the inflated balloon is 8 cm in diameter and 3-4 cm in height. The balloon will sweep the amniotic membrane away from the cervix, causing the release of prostaglandins which helps ripen the cervix and initiates uterine contractions. The improved shape of the balloon causes the cervix to be 6-8 cm dilated once it is expelled. This catheter also contains a flexible guidewire that allows for easier insertion for the provider, and makes insertion less painful for the patient because it can be placed without a speculum and ring forcep being used. This catheter could actually be placed on an outpatient basis or in the doctor's office, with the patient instructed to go to the hospital or birthing unit when the catheter falls out. This catheter is smaller in diameter than the 16 French Foley catheter, so therefore it can be placed when the patient is <1 cm dilated. This catheter when placed properly and secured to the patient's thigh with tension applied can shorten labor by 4-10 hours.

A method and apparatus for implementing a user interface for displaying uterine contraction information is provided. The contraction signal is processed to derive a sequence of contraction persistence indices. Each contraction persistence index in the sequence is associated to a portion of the contraction signal and conveys whether there is an excess in the rate of contraction in the associated portion of the contraction signal. If there is an excess in the rate of contraction in the associated portion of the contraction signal, the contraction persistence index conveys whether this excess is part of a sustained pattern of excess in the rate of contractions or whether the excess is likely to be transient. The sequence of contraction persistence indices is displayed to a user. Optionally, the graphical user interface is adapted for selectively causing an alarm event based at least in part on the sequence of contractility persistence indices. The method and apparatus may be implemented on any suitable computing platform such as for example desktop computers, laptop computers and personal digital assistants (PDAs).

The invention discloses a daily ration concentrated feed of an egg-laying sheldrake. The daily ration concentrated feed comprises wheat bran, beer yeast, rice bran, fish meal, shell powder, bean dregs, rape seed cake, mineral additive premix, vitamin additive premix, salt and Chinese herb feed additive, wherein the Chinese herb feed additive comprises following raw bulk drugs: rhizoma polygonati, pericarpium citri reticulatae, Chinese angelica, fructus psoraleae, folium isatidis, bletilla striata, calcined oyster shell, bighead atractylodes rhizome, radix salviae miltiorrhizae, semen cuscutae, dandelion, leonurus, red paeonia, medical stone, astragalus mongholicus, patrinia, scutellaria baicalensis, fructus cnidii and hawthorn. Aiming to the physiological characteristics that during egg laying, the vital energy and blood of a sheldrake body is weak, and the function of ovary is gradually declined and the physical characteristic that a sheldrake lays an egg in the small hours certainly, on the basis of theories of the Chinese Veterinary Medicine, the invention adopts the component with the purposes of eliminating dampness, strengthening the spleen and stomach, tonifying middle-Jiao and Qi and enhancing resistance to diseases, so that reproductive endocrine system is improved, follicular development is promoted, uterine contraction is adjusted, egg laying is facilitated, egg laying rate is effectively improved, egg quality is improved, and good economic benefits and social benefits are created.

An apparatus (10) for measuring one or more labor progress parameters (25) as the dilation of the endocervical canal (8), the rotation and the position of the head (4) of the foetus (3) during the descent, the duration and the intensity of the uterine contractions, other morphological and physiological parameters, without introducing foreign objects into the body of a pregnant woman (2) and independently from the sensitivity of the operator. The apparatus (10) comprises automatic means for tracking, in a sequence of ultrasound images (11,12) that are obtained by an ultrasound probe (1), one or more regions of interest (ROI, 21), that may be both two-dimensional or three-dimensional and are centred about anatomic reference points (28) that define said parameters selected in a reference image by a displaying unit (14). The tracking means comprises: a) a means for calculating a function (f) at the pixels of the ROI of the reference image and of images preferably sampled among the images of the sequence, b) a means for calculating iteratively at the positions of the ROI in subsequent images, by a means of comparison between the values of the function (f) calculated in the pixels of the ROI of a current image and the values of the function (f) calculated in the pixels of the ROI of a subsequent ultrasound image; c) a means for comparing each position of the ROI with the position of the ROI in the reference image and for calculating the labor progress parameter responsive to said comparison. The new position of the region of interest may be defined as a domain in which a predetermined object function assumes a minimum value.

Apparatus for controlling the childbirth labor comprising an electromyographic unit (4) with sensors (3) for detecting electrical signals of a parturient's uterus and means (6) for analyzing and processing the electrical signals, and a pneumatic belt (1) to be fixed around the parturient's abdomen having sensors (15) to detect the variation of the internal pressure due to uterine contractions, and means (2) for inflating the belt to provide a thrust as an aid for the expulsion of the fetus, where a device (7) is provided, associated with sensors (15) and (3) to control the activation of means (2) for the inflation of the pneumatic belt (1).

Systems and methods for applying stimulating current to a patient for treating insufficient uterine contractions are provided. The system includes stimulation electrodes of a balloon electrode array device, a ring electrode array device, an electrode probe device, or a mesh electrode array device. Some aspects of the invention also provide a connector and cable device for coupling the stimulation electrodes to electronics for generating and providing the stimulating current to the stimulation electrodes.

Described herein are systems and methods for contraction monitoring. For example, a system for contraction monitoring includes an electrode patch including at least two electrodes, and a sensor module configured to be connected to the electrode patch. In some embodiments, the sensor module includes a signal acquisition module, a signal processing module, a power management module, a sensor control module, and a memory module and / or a data transmission module. In some embodiments, a method for contraction monitoring includes measuring, using the signal acquisition module, bio-potential signals by providing at least two electrodes on the abdomen of a pregnant woman. In some embodiments, a method for contraction monitoring includes processing, using the signal processing module, the bio-potential signal to extract electrohysterogram signals, maternal electrocardiogram signals and fetus electrocardiogram signals, and processing using the signal processing module, the individual signals to extract uterine contraction.

Systems and methods for monitoring uterus contraction activity and progress of labor. The system of the subject invention can comprises (1) a plurality of sensors; (2) an amplifying / filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, progress of labor, prediction and monitoring of preterm labor, and intrauterine pressure prediction. In a preferred embodiment, the system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis as well as delivery strategy.

Systems and methods for monitoring uterus contraction activity and progress of labor. The system of the subject invention can comprises (1) a plurality of sensors; (2) an amplifying / filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, progress of labor, prediction and monitoring of preterm labor, and intrauterine pressure prediction. In a preferred embodiment, the system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis as well as delivery strategy.

A method is taught for the accurate determination of the premature rupture of membranes (PROM), defined as spontaneous rupture of membranes before the onset of uterine contractions. More specifically, a lateral flow assay strip tests for at least two antigens to greatly limit or eliminate the possibility of false negatives. A built in timer in the cassette holding the lateral flow assay further increases the accuracy of the test. A collection buffer vial with self-contained shipping and dropper caps and built in stand is also taught.

A apparatus for automatically detecting a pregnancy status of a patient include a patch for adhering to human skin, a uterine contraction sensor, such as electromyography (EMG), coupled to the patch with at least two electrodes, and an inertial sensor for sensing fetal movement, or fetal heart rate (FHR) sensor, such as fetal EKG or a Doppler ultrasound. An electronic circuit is coupled to the patch, the EMG sensor and the inertial sensor, and / or FHR sensor. The circuit provides an output based on a uterine contraction signal from the EMG sensor (or the Doppler ultrasound) correlated in time to a fetal movement, and / or fetal heart rate. The apparatus may include a thermometer to aid in automatically providing an indication of a pregnancy complication or ovulation status of the patient, based on the output.

The invention discloses a small-scale continuous dynamic fetus monitor comprising a shell, a touch control display screen, a volume adjustment button, a power switch, probe interfaces, winding type signal filters, fetal heart fetal movement probes, an uterine contraction probe, uterine myoelectricity fetus electro-cardio probes, a loudspeaker, an uterine contraction zero returning key, a storage card insertion hole, a power indicator, a data line interface, a network cable interface, a CPU control main board, a rear cover, a cellular network card groove, a battery bin, hook junction parts, an elastic band, a net-shaped waist and abdominal belt and hook bodies. The touch control display screen and the battery bin are arranged on the front face and the back face of the shell respectively. The problems that the fetal heart, fetal movement, uterine contraction and other indexes can not be continuously and dynamically monitored clinically are solved. More fetus health indexes can be provided for clinical work, and effective support is provided for clinic to rapidly and timely solve the problem of unforeseen circumstances happening on fetuses.