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46 results about "Preterm labor" patented technology
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Term labor Definition: One of the four basic categories of resources, or factors of production (the other three are capital, land, and entrepreneurship). Labor is the services and efforts of humans that are used for production.
Methods for inhibiting preterm labor and uterine contractility disorders and preventing cervical ripening
InactiveUS20130023505A1Inhibit uterine contractilityInhibit cervical ripeningOrganic active ingredientsPharmaceutical delivery mechanismMyometrial contractilityGynecology
The invention relates to methods and pharmaceutical compositions for inhibiting or preventing preterm birth, inhibiting or delaying cervical ripening, inhibiting myometrial contractility and treating or inhibiting uterine contractility disorders. The methods comprise administering an effective amount of a composition comprising steroid hormones such as soluble progesterone.
Owner:DIGNITY HEALTH
System and Method for Analyzing Progress of Labor and Preterm Labor
ActiveUS20090299212A1Improve satisfactionAccurate identificationElectromyographyPerson identificationGraphicsNeural network system
Systems and methods for monitoring uterus contraction activity and progress of labor. The system of the subject invention can comprises (1) a plurality of sensors; (2) an amplifying / filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, progress of labor, prediction and monitoring of preterm labor, and intrauterine pressure prediction. In a preferred embodiment, the system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis as well as delivery strategy.
Owner:UNIV OF FLORIDA RES FOUNDATION INC +1
Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
A method and a pharmaceutical composition for inhibiting premature rapture of the fetal membranes, ripening of the uterine cervix and preterm labor of female mammals including human. The method includes the step of administering compounds for reversing at least two biochemical conditions being associated with the above processes. The pharmaceutical composition includes compounds for reversing at least two biochemical conditions being associated with the above processes.
Owner:LEIBOVITZ SHAMIR
Devices and methods for cervix measurement
The present invention provides devices having an elongated member, a stop slidably engaged with the member and preferably a measuring scale to determine dimensions of female reproductive organs. Preferably, the device is adapted to determine the length of the cervix in the fornix vaginae, which is used in the disclosed methods to predict the risk of preterm labor, risk of miscarriage, ease or difficulty of inducing labor, and fertility of an individual. Additional embodiments of the device determine dimensions of the fornix vaginae and dilation of the cervix uteri.
Owner:CERVILENZ
Tricyclic pyridyl carboxamides and derivatives thereof tocolytic oxytocin receptor antagonists
This invention provides novel substituted tricyclic pyridyl carboxamides which act as oxytocin receptor competitive antagonists, as well as methods of their manufacture, pharmaceutical compositions and methods of their use in treatment, inhibition, suppression or prevention of preterm labor, dysmenorrhea, endometritis, suppression of labor at term prior to caesarean delivery, and to facilitate antinatal transport to a medical facility. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals; and may be useful in the prevention and treatment of disfunctions of the oxytocin system in the central nervous system including obsessive compulsive disorder (OCD) and neuropsychiatric disorders.
Owner:WYETH LLC
System for monitoring pregnancy in mammals
InactiveUS20140073879A1Prevent free movementEasy to adaptAnimal reproductionSensorsObstetricsPregnancy
A system is disclosed for long term, continuous, monitoring of pregnant mammals particularly to detect the onset of preterm labor. For example, the system enables communication between sensors and a collection unit for transmittal to a remote unit for display and monitoring of the collected data by a clinician while the individual is ambulatory and not in the presence of the clinician.
Owner:MB DEVICE
Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same
Crystalline (3Z,5S)-5-(hydroxymethyl)-1-[(2′-methyl-1,1-biphenyl-4-yl) carbonyl]pyrrolidin-3-one O-methyloxime is disclosed. A pharmaceutical composition containing the crystalline compound and methods for treating conditions related to the OT-R activity, such as preterm labor, and tor increasing embryo implantation rate in a mammal undergoing embryo transfer, comprising administering the crystalline compound are also disclosed.
![Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same](https://images-eureka.patsnap.com/patent_img/a7101a18-4595-4dc1-b537-32c576720778/US20160002160A1-20160107-D00001.PNG "Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same")
![Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same](https://images-eureka.patsnap.com/patent_img/a7101a18-4595-4dc1-b537-32c576720778/US20160002160A1-20160107-D00002.PNG "Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same")
![Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same](https://images-eureka.patsnap.com/patent_img/a7101a18-4595-4dc1-b537-32c576720778/US20160002160A1-20160107-D00003.PNG "Crystalline (3z,5s)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one o-methyloxime, and methods of using the same")
Owner:OBSEVA
System and Method for Analyzing Progress of Labor and Preterm Labor
ActiveUS20120238894A1Save the hospital moneySave effortElectromyographySensorsObstetricsGraphical user interface
Systems and methods for monitoring uterus contraction activity and progress of labor. The system of the subject invention can comprises (1) a plurality of sensors; (2) an amplifying / filtering means; (3) a computing means; and (4) a graphical user interface. Accurate clinical data, which can be extracted and provided to the user in real-time using the system of the invention, include without limitation, progress of labor, prediction and monitoring of preterm labor, and intrauterine pressure prediction. In a preferred embodiment, the system of the invention includes an intelligence means, such as a neural network system, to analyze and interpret clinical data for use in clinical diagnosis as well as delivery strategy.
Owner:UNIV OF FLORIDA RES FOUNDATION INC +1
Systems and methods for monitoring uterine activity and assessing pre-term birth risk
A method for uterine activity monitoring may include: acquiring a plurality of signals from a plurality of sensors during uterine activity; processing the plurality of signals to extract a plurality of uterine electrical activity characteristics; analyzing the plurality of uterine electrical activity characteristics; and classifying the uterine activity as one of: a preterm labor contraction, a labor contraction, a Braxton-Hicks contraction, and a state of no contraction. A method of assessing over time a pre-term birth risk of a pregnant female may include: calculating a baseline pre-term birth risk score based on a user input; acquiring, over time, a signal from a sensor; analyzing the signal to extract a parameter of interest, such that the parameter of interest comprises a physiological parameter; and calculating an instant pre-term birth risk score based, at least in part, on the parameter of interest and the user input.
Owner:BLOOM TECH NV
Preterm labor monitor
A system, method and apparatus for monitoring uterine and / or cervical activity indicative of labor in a patient. The system includes a medical device and a data processor in communication with the medical device. The medical device includes a structural component, a first electrode attached to the structural component, and a second electrode attached to the structural component. The structural component is structured to be in contact with a cervical surface and a vaginal surface of the patient, such that said first electrode is in electrical contact with said cervical surface and said second electrode is in electrical contact with said vaginal surface. The first electrode is adapted to receive an electrical activity of the cervical surface and the second electrode is adapted to receive an electrical activity of the uterus through the vaginal surface. The data processor is adapted to process the electrical activity of the electrodes to detect contractions on a surface of the patient indicative of labor.
Owner:ROSE HUANG +6
Methods and compositions for diagnosing complications of pregnancy
ActiveUS20100291585A1Improve stabilitySugar derivativesMicrobiological testing/measurementComplicated pregnancyComplications of pregnancy
The present invention provides methods and compositions for identifying subjects at risk of developing a complication of pregnancy, such as preeclampsia or preterm labor. The compositions are microRNAs and associated nucleic acids.
Owner:ROSETTA GENOMICS +1
System and method for analyzing progress of labor and preterm labor
ActiveUS8160692B2Save the hospital moneySave effortElectromyographySensorsObstetricsGraphical user interface
Owner:UNIV OF FLORIDA RES FOUNDATION INC +1
Method for determination of likelihood of occurrence of preterm labor in pregnant females
InactiveUS20060166295A1More productiveAccelerated destructionOrganic active ingredientsDisease diagnosis3-ChlorotyrosineObstetrics
The presence of 3-chlorotyrosine in vaginal secretions in a predictor of the likelihood preterm premature rupture of the fetal membranes, i.e., the chorioamnion and / or the occurrence of the risk of preterm labor. 3-chlorotyrosine is a marker for the excessive production of hypochlorous acid which causes focal areas of increased collagen destruction in the chorioamnion, preterm premature rupture of membranes, or increased production of postaglandin and preterm labor. The inventive method comprises determining the likelihood of the occurrence of preterm premature rupture of membranes or increased production of postaglandin and preterm labor in a pregnant female by obtaining a sample of the females vaginal secretions, and analyzing the secretions for the presence and amount of 3-chlorotyrosine in the sample. Various antibody-based tests can be used to measure 3-chlorotyrosine, and a number of neoantigens, useful in raising antibodies to 3-chlorotyrosine, are disclosed.
Owner:UNIVERSITY OF ROCHESTER
Diagnostic agents for prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing same
InactiveCN1476537AMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementPrenatal diagnosisObstetrics
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method, diagnostic reagent system, and kit are based on the finding that the level of MMP-8 in the amniotic fluid is significantly higher when the pregnant woman is at risk for preterm delivery, intrauterine infection, and fetal damage. The diagnostic reagent system and kit can be applied to the patients without, as well as with, clinical signs of preterm labor or premature rupture of fetal membranes. With the superiority in sensitivity and specificity as well as its less invasiveness compared to the conventional method of measuring fetal blood cytokine levels, this diagnostic reagent system and kit is very useful in the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage.
Owner:SEOUL NAT UNIV R&DB FOUND
Methods and kits for predicting risk for preterm labor
InactiveCN101509917AMitigate Downstream ProblemsLearn about applicabilityMicrobiological testing/measurementDisease diagnosisObstetricsCell-Extracellular Matrix
The invention is directed to kits and methods that allow one to predict the risk for preterm labor in a pregnant woman. The inventors have discovered that various extracellular matrix components can be detected in cervical secretions. The quantification of certain extracellular matrix proteins found within cervical secretions can be used as a diagnostic for the biomechanical state of the cervix, which indicates whether preterm labor is likely. Some extracellular matrix components that can be found in cervical secretions include decorin, thrombospondins and matrix metalloproteinases.
Owner:CERVIMARK
Method and pharmaceutical composition for inhibiting premature rapture of fetal membranes, ripening of uterine cervix and preterm labor in mammals
InactiveUS20050163771A1Improve the level ofHigh levelPeptide/protein ingredientsImmunoglobulins against cytokines/lymphokines/interferonsObstetricsMammal
A method and a pharmaceutical composition for inhibiting premature rapture of the fetal membranes, ripening of the uterine cervix and preterm labor of female mammals including human. The method includes the step of administering compounds for reversing at least two biochemical conditions being associated with the above processes. The pharmaceutical composition includes compounds for reversing at least two biochemical conditions being associated with the above processes.
Owner:LEIBOVITZ SHAMIR
Methods for diagnosing and treating pre-term labor
InactiveUS20050260683A1Good indicator of initiation of laborPromoting transcriptionCompound screeningApoptosis detectionFoetal membranesLabor induction
In accordance with the present invention, recombinant human PBEF has been produced in order to study its ability to stimulate the transcription of the key cytokine mediators of labor induction, using the amnion-like epithelial (WISH) cell line and fetal membrane explants. As a result of these studies, it has been determined that PBEF is a good indicator of initiation of labor. This makes PBEF a useful marker, especially for the identification of subjects who have initiated preterm labor. Accordingly, methods for the identification of subjects who have commenced labor are provided. In addition, methods are also provided for blocking labor, as well as compositions useful therefor. This is accomplished by blocking the production of PBEF or by blocking the action of PBEF.
Owner:UNIV OF HAWAII
Monitoring uterine activity and assessing pre-term birth risk
A method for uterine activity monitoring may include: acquiring a plurality of signals from a plurality of sensors during uterine activity; processing the plurality of signals to extract a plurality of uterine electrical activity characteristics; analyzing the plurality of uterine electrical activity characteristics; and classifying the uterine activity as one of: a preterm labor contraction, a labor contraction, a Braxton-Hicks contraction, and a state of no contraction. A method of assessing over time a pre-term birth risk of a pregnant female may include: calculating a baseline pre-term birth risk score based on a user input; acquiring, over time, a signal from a sensor; analyzing the signal to extract a parameter of interest, such that the parameter of interest comprises a physiological parameter; and calculating an instant pre-term birth risk score based, at least in part, on the parameter of interest and the user input.
Owner:BLOOM TECH NV
Salivary Protease Assays for Identifying Increased Risk of Preterm Delivery Induced by Premature Rupture of Fetal Membranes
InactiveUS20080254490A1Increased riskAvoid laborMicrobiological testing/measurementDisease diagnosisProteinase activityAmniotic fluid
Assay methods for identifying an increased risk of preterm delivery induced by premature rupture of the fetal membranes are provided. More specifically, the invention provides salivary protease assays indicative of amniochorion and fetal membrane concentrations of proteases involved in the degradation of the fetal membranes leading to rupture. An increase in salivary protease levels beyond normal or individual baseline provides an indication that protease levels in fetal membranes and / or the amniotic fluid are abnormally elevated. Abnormally elevated protease levels define an increased risk of a premature delivery caused by rupture of the fetal membranes. Thus, abnormally high levels of salivary protease levels indicates elevated risk of PROM, and provides an indication for therapeutic intervention to prevent PROM-induced preterm labor.
Owner:MENON RAMKUMAR
Methods for diagnosing labor
In accordance with the present invention, recombinant human PBEF has been produced in order to study its ability to stimulate the transcription of the key cytokine mediators of labor induction, using the amnion-like epithelial (WISH) cell line and fetal membrane explants. As a result of these studies, it has been determined that PBEF is a good indicator of initiation of labor. This makes PBEF a useful marker, especially for the identification of subjects who have initiated preterm labor. Accordingly, methods for the identification of subjects who have commenced labor are provided. In addition, methods are also provided for blocking labor, as well as compositions useful therefor. This is accomplished by blocking the production of PBEF or by blocking the action of PBEF.
Owner:UNIV OF HAWAII
Compositions and methods for healthy pregnancy
InactiveUS20070071716A1Avoid laborReduce frequencyOrganic active ingredientsPeptide/protein ingredientsPreterm laborImplantation failure
Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The compositions, kits and methods provide an effective amount of granulocyte colony stimulating factor to prevent, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure of an embryo.
Owner:NORA THERAPEUTICS
Method and System to Monitor the State and Function of the Cervix and Effects of Treatments for the Cervix
InactiveUS20130090538A1Precise deliveryTrue laborDiagnostics using fluorescence emissionSensorsCervical tissueObstetrics
A method operable to more accurately monitor the state and function of the cervix is provided. Embodiments of the present invention relate generally to detection of fluorescence from the female mammalian cervix. More particularly, embodiments of the present invention relate to predicting true term and preterm labor and delivery, characterizing the function and state of the cervix, and for assessing and monitoring the efficacy of treatments for the cervix. Embodiments of the present disclosure use light induced fluorescence (LIF) via a non-invasive optical probe to accurately and quantitatively measure changes in the cervical tissue during pregnancy and labor. As gestational age increases, the LIF decreases. Ideally, cervical collagen should be at a minimum just prior to delivery. The present invention can be used to monitor the state and function of the cervix during pregnancy, as well as efficacy of cervical treatments during pregnancy.
Owner:GARFIELD ROBERT +2
Method of reducing the likelihood of implantation failure during an assisted reproduction in a female subject in a need thereof
InactiveUS7470662B2Reduce frequencyPrevent spontaneous abortionOrganic active ingredientsPeptide/protein ingredientsGynecologyAbortion
Compositions, kits and methods for the prevention of, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure during assisted reproduction are provided. The compositions, kits and methods provide an effective amount of granulocyte colony stimulating factor to prevent, for example, spontaneous abortion, preeclampsia, preterm labor or implantation failure of an embryo.
Owner:NORA THERAPEUTICS
Composition and method for treatment of preterm labor
InactiveUS20110236392A1Inhibition of activationReduce deliveryBiocidePeptide/protein ingredientsNeonatal morbidityMortality rate
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.
Owner:TRINITY COLLEGE DUBLIN +1
Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor
Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST +1
Methods and compositions for the prevention and treatment of genitourinary disorders, including pre-term labor and leiomyomas
InactiveUS20090053207A1Microbiological testing/measurementLibrary screeningCOMT inhibitorUterine disease
The present invention relates to an association between specific polymorphisms of the COMT polypeptide and the development, or risk of developing, preterm labor and uterine diseases and conditions. Disclosed are therapeutic, preventative and diagnostic methods and compositions relating to pre-term labor, uterine diseases and conditions, and ovarian conditions and diseases. In certain embodiments, such methods and compositions involve a COMT inhibitor.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
Methods and compositions for diagnosing complications of pregnancy
ActiveUS8580503B2Improve stabilitySugar derivativesMicrobiological testing/measurementComplicated pregnancyComplications of pregnancy
Owner:ROSETTA GENOMICS +1
Preterm labor monitor
A system, method and apparatus for monitoring uterine and / or cervical activity indicative of labor in a patient. The system includes a medical device and a data processor in communication with the medical device. The medical device includes a structural component, a first electrode attached to the structural component, and a second electrode attached to the structural component. The structural component is structured to be in contact with a cervical surface and a vaginal surface of the patient, such that said first electrode is in electrical contact with said cervical surface and said second electrode is in electrical contact with said vaginal surface. The first electrode is adapted to receive an electrical activity of the cervical surface and the second electrode is adapted to receive an electrical activity of the uterus through the vaginal surface. The data processor is adapted to process the electrical activity of the electrodes to detect contractions on a surface of the patient indicative of labor.
Owner:ROSE HUANG +6
Treatment of preterm labor with toll-like receptor 9 antagonists
InactiveUS8933011B2Inhibition of activationReduce deliveryBiocidePeptide/protein ingredientsNeonatal morbidityMortality rate
Owner:TRINITY COLLEGE DUBLIN +1
Therapeutics for preterm labor management
ActiveUS20180360806A1Reduce productionFunction increaseOxytocins/vasopressinsOrganic active ingredientsObstetricsUterus
Methods and compositions are provided for treating and preventing preterm labor using liposome encapsulated tocolytic agents, such as indomethacin. In certain aspects, targeted liposomes are provided that allow delivery of tocolytic agents directly to the uterus, such as by targeting to the oxytocin receptor.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST +1
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