8 results about "Oxytocin" patented technology

The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.

The application provides an application of a traditional Chinese medicine preparation in preparation of a drug for treating dysmenorrhea, and an active ingredient of the traditional Chinese medicine preparation is prepared from liquorice, asarum, cassia twig, angelica, white peony root, common sage and chuanxiong. The traditional Chinese medicine preparation provided by the application fuses multi-dimensional treatment strategies of warming meridians, nourishing blood, regulating qi and dredging collaterals, and can cover different TCM syndrome types such as cold coagulation and blood stasis, qi stagnation and blood stasis and qi and blood deficiency. Pharmacological experiments show that for dysmenorrhea rats of the cold coagulation and blood stasis type, the traditional Chinese medicine preparation of the application can reduce the sensitivity of the uterus caused by benzoic acid estradiol and inhibit the writhing reaction of the rats caused by oxytocin, which indicates that the traditional Chinese medicine preparation of the application has the effect of treating dysmenorrhea.

The present document relates to the field of agriculture and a method for stimulating germination of plants. More specifically, the present document relates to a method for seed soaking of seeds to stimulate their germination, a composition for such use and seeds after seed soaking. The method comprises soaking the seeds in an aqueous solution comprising oxytocin, a fragment thereof or a variant thereof, wherein the seeds are not allowed to germinate in the oxytocin solution. The result shows that this results in a stronger growth enhancing effect on the seeds.

The present application relates to the technical field of aquaculture, and particularly relates to an artificial breeding method of Cottus hangi in Xingkai Lake. The present application uses LRH-A2 and HCG combination oxytocin to reasonably inject female parent fish and male parent fish, especially to twice injection of female parent fish, and strictly controls injection dose of each injection and reasonable control time interval, which not only can efficiently induce labor, but also can reach 95% of the female parent fish induction efficiency, and can obtain good ovum and semen, so that the ovum can be better fertilized, the quality of the fertilized ovum is improved, the hatching rate is improved, the stress of the parent fish is reduced, and the death of the parent fish is reduced. The present application improves the physical fitness of the parent fish through reasonable parent fish cultivation, and combines reasonable artificial induction operation and post-production nursing measures, so that the post-production death of the parent fish is reduced from multiple aspects, and the post-production survival rate of the parent fish is significantly improved, so that the repeated cultivation cost of the parent fish is reduced.

This invention discloses a mouse experimental method for detecting the tissue distribution of exogenous oxytocin, belonging to the field of biotechnology. Specifically, oxytocin is injected into or nasally sprayed into oxytocin knockout mice, and body tissues, including but not limited to brain tissue, mammary gland tissue, blood, heart tissue, uterine tissue, bone tissue, and muscle tissue, are collected at different time points. The tissue distribution and content of oxytocin are then detected using liquid chromatography-mass spectrometry (LC-MS / MS). This experimental method allows for a wider range of experimental samples, not just focusing on brain tissue and blood; it also has higher sensitivity and stronger specificity; and by utilizing oxytocin gene knockout mice, it eliminates the influence of endogenous oxytocin, providing certain assistance for subsequent animal experiments and clinical research on oxytocin.

The present invention provides cyclic oligopeptides and methods for using the same. The cyclic oligopeptides of the invention are analogues of oxytocin wherein the disulfide linkage between Cys1 and Cys2 are replaced with a more stable amide bond. The cyclic oligopeptides of the invention can also include a glycoside to increase blood-brain barrier penetration. In particular, the cyclic oligopeptide of the invention is of the formula: (A) (SEQ ID NO:2) where one of AA1 or AA6 is an amino acid having a carboxylic acid side-chain and the other is a carboxylic acid having an amine functional group on the side-chain such that X1 and X2 together form an amide bond; and each of AA2-AA5 and AA7-AA11 is independently natural or unnatural amino acids with at least one, typically at least two, often at least three, more often at least four, and most often at least five of which is an amino acid that is present in the corresponding position of oxytocin.

This invention relates to a method for regulating the late autumn breeding of mandarin fish, belonging to the field of artificial fish breeding in aquaculture technology. The operation of this invention is as follows: (1) Inducing spawning in spring by injecting a high dose of a single oxytocin into the mandarin fish parent stock; (2) Under the action of the high dose of the single oxytocin, partial spawning is completed, achieving an average spawning volume per female fish of 20%-30% of the theoretical spawning volume in spring; (3) After spawning until the end of June, controlled feeding management is carried out to reduce the amount of feed, so that the fish are in a nutritional state of maintenance or slow growth; (4) In July and August, nutritional enhancement cultivation is carried out, and sufficient feeding is restored for a period of time before formal spawning to promote the rapid secondary development of the gonads of the parent mandarin fish; oxytocin is injected at a conventional effective dose to induce artificial insemination of the parent mandarin fish, resulting in concentrated spawning, achieving an average spawning volume per female fish of 80%-90% of the spawning volume in autumn. This invention can achieve the dual use of mandarin fish parent stock in one year through conventional hormone injection and feed management.

This utility model discloses a breast pump that mimics infant sucking, relating to the field of breast pump technology. It includes a milk bowl, a breast pump main unit connected to the milk bowl, and a bra structure. The bra structure includes a breast shield with an elastic, mimicking sucking inner airbag assembly. The breast pump main unit includes an air source device connected to the elastic, mimicking sucking inner airbag assembly. When the air source device inflates or deflates the elastic, mimicking sucking inner airbag assembly, the assembly deforms to expand or contract, producing an effect similar to infant sucking. This mimicking infant sucking action effectively stimulates the mother's mammary glands and promotes oxytocin secretion. This design, by simulating the natural breastfeeding process, helps trigger the "milk release" reflex, causing milk to spray out after appropriate stimulation of the mammary glands. Compared to the single negative pressure mode of traditional breast pumps, this biomimetic design is more conducive to improving lactation efficiency.