76 results about "Oxytocin" patented technology

Disclosed herein is a stable oxytocin composition having between about 0.04 and 0.08 IU / mL of oxytocin and / or a pharmaceutically acceptable salt thereof, a buffer comprising sodium acetate trihydrate and acetic acid, a tonicity adjusting agent comprising sodium chloride, a pH adjusting agent comprising acetic acid, sodium hydroxide, or a combination thereof, and water, the composition having a total impurities concentration of equal to or less than 16% after storage of at least six months at 25° C. Also disclosed herein is a pharmaceutical product having a single-use container containing the sterile and storage-stable liquid composition of the present disclosure.

The present disclosure relates to methods for treating and / or preventing diseases and disorders using oxytocin, and compositions relating to the same.

The invention relates to steroids and / or functional analogues thereof for use in a method of treating an individual suffering from sexual dysfunction. Said steroids may be combined with an effective dosage of oxytocin and / or a functional analogue thereof.

The present disclosure discloses a voltammetric sensor for the detection of oxytocin. The voltammetric sensor comprises a gold electrode. The gold electrode comprises lead oxide (PbO) nanoparticles. The present disclosure also discloses a method of detecting oxytocin using a voltammetric sensor, the voltammetric sensor comprising a gold electrode, the gold electrode comprising lead oxide (PbO) nanoparticles. The method of detecting oxytocin comprises the steps of positioning a liquid droplet, comprising solvent and analyte, to be tested on a sensing area of the gold electrode; receiving a voltammetric response from the electrode; and analysing the voltammetric response to determine if oxytocin is present in the liquid droplet.

The application relates to the technical field of animal models, in particular to a modeling method and an evaluation method of an animal menstrual dysmenorrhea model and application, wherein the animal with removed ovaries is injected with estrogen, progesterone and oxytocin, the pharmacological injection of progesterone can reduce the harm and mortality rate of the animal caused by the implantation and removal of a progesterone release body in the prior art, the surgical stress of the animal is reduced, the injection time of the progesterone in the application is 7-9 days, and the animal menstrual dysmenorrhea model is obtained after the progesterone is withdrawn for 16 hours; after evaluation by the evaluation method, compared with the non-menstrual process of the dysmenorrhea model in the prior art, the animal menstrual dysmenorrhea model can better simulate the pathophysiological process of human dysmenorrhea, promote the development of clinical treatment, and effectively help patients to relieve pain.

To provide a composition and a method for administering an oxytocin antagonist to a subject undergoing embryo implantation therapy so as to improve endometrial receptivity and reduce the likelihood of embryo implantation failure in the subject.SOLUTION: The present invention provides a pharmaceutical composition for use in a method that employs a compound represented by formula (II) to treat a subject undergoing embryo implantation therapy, in which one or more embryos are transplanted into the uterus of the subject, wherein the method comprises administering the compound to the subject in an amount of about 1,800 mg.SELECTED DRAWING: Figure 1

A formulation (12) that creates a hormonal response in the body through a topical application. The topical formulation (12) contains botanicals in the form of jasmine flower extract and carob fruit extract. The botanicals are mixed with phospholipids and peptides to promote the absorption of the botanicals into the skin. Once applied to the skin, the jasmine flower extract and the carob fruit extract induce a hormonal response in the body. The hormonal response stimulates the oxytocin neural pathways in the body. This causes the body to believe that oxytocin is present, therein triggering the release of oxytocin within the body. The presence of the oxytocin facilitates physical and pro-social psychological improvements that include an improved libido, improved self-esteem, and improved self-confidence.

The present invention discloses a method for synthesizing oxytocin. The method utilizes a novel amino non-classical solid-phase synthesis carrier and adopts the Fmoc-synthesis method to complete the synthesis of oxytocin. Under the same production scale, the volume of the reactor can be reduced by 30%-50%, the amount of raw amino acids and condensing agents can be reduced by 50%-60%, and the amount of organic solvents used for reaction and washing can be reduced by 60%-80%, ultimately achieving a 50%-70% reduction in production costs. The carrier prepared by the present invention can realize the large-scale production of polypeptide products, effectively reduce production costs, improve production efficiency, reduce environmental pollution, and be environmentally friendly.

The invention discloses application of oxytocin to preparation of a medicine for preventing and treating postoperative cognitive impairment and the medicine. The invention discloses a mechanism of the oxytocin for preventing or treating the postoperative cognitive impairment for the first time, finds that the oxytocin can promote the expression of PI3K / Akt / mTOR pathway related protein in the hippocampal brain region and relieve the activation of microglial cells in the hippocampal brain region for the first time, and can prevent or treat the postoperative cognitive impairment by being locally administrated to the hippocampal brain region. The invention provides the application of oxytocin in the medicine for preventing or treating the postoperative cognitive impairment, and provides a new thought for the medicine for preventing or treating the postoperative cognitive impairment.

The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.

The application provides an application of a traditional Chinese medicine preparation in preparation of a drug for treating dysmenorrhea, and an active ingredient of the traditional Chinese medicine preparation is prepared from liquorice, asarum, cassia twig, angelica, white peony root, common sage and chuanxiong. The traditional Chinese medicine preparation provided by the application fuses multi-dimensional treatment strategies of warming meridians, nourishing blood, regulating qi and dredging collaterals, and can cover different TCM syndrome types such as cold coagulation and blood stasis, qi stagnation and blood stasis and qi and blood deficiency. Pharmacological experiments show that for dysmenorrhea rats of the cold coagulation and blood stasis type, the traditional Chinese medicine preparation of the application can reduce the sensitivity of the uterus caused by benzoic acid estradiol and inhibit the writhing reaction of the rats caused by oxytocin, which indicates that the traditional Chinese medicine preparation of the application has the effect of treating dysmenorrhea.

Combination therapies comprising oxytocin and gonadotropin releasing hormone are provided. The combinations can be used to treat aging-related neurological diseases or disorders. In addition, downstream effectors of OXT-GnRH combination, including hypothalamic stem / progenitor cells-derived EVs and vesicles containing or loaded with PTMS, can be used to treat aging-related neurological diseases or disorders.

Disclosed herein is a stable oxytocin composition having between about 0.01 and 0.07 IU / mL of oxytocin and / or a pharmaceutically acceptable salt thereof, one or more tonicity adjusting agents, a buffer, one or more pH adjusting agents, and water, the composition having a total impurities concentration of equal to or less than 16% after storage of at least six months at 25° C. Also disclosed herein is a pharmaceutical product having a single-use container containing the sterile and storage-stable liquid composition of the present disclosure.

Failures in establishing trust during international conflict negotiations frequently result in warfare, as ideological differences often cannot be resolved through rational discourse alone. Empathy between opposing parties is essential for building trust, and oxytocin is recognized for its critical role in facilitating empathy, trust, inter-brain synchrony, and cooperative decision-making. However, prevailing scientific studies typically do not differentiate between the cis and trans isomers of oxytocin, despite evidence that only the trans isomer is pharmacologically active. The present invention provides methods for the separation and quantification of oxytocin isomers, with particular emphasis on the trans isomer's function in social synchrony and decision-making within conflict negotiation contexts. Additionally, the invention explores the role of extremely low frequency electromagnetic radiation permeating the human central nervous system interconnecting neurochemical changes among groups. These advances clarify the unique neuropeptide functions of oxytocin and enhance understanding of its impact on cooperation and conflict resolution.

The present disclosure relates to oxytocin peptide analogs, or an enantiomer, racemate, tautomer, hydrate, solvate thereof, or pharmaceutically acceptable salts of any of them, and pharmaceutical compositions and formulation of them and methods for the treatment of various medical conditions associated with inadequate OTR activity in subjects in need thereof. These methods comprise administration of an oxytocin peptide analog of this disclosure, or an enantiomer, racemate, tautomer, solvate, hydrate thereof, or pharmaceutically acceptable salts of any of them, or pharmaceutically acceptable compositions or formulation containing them, to a subject in need thereof.

Disclosed is a method for increasing the bud opening and / or longevity of cut flowers by exposing the cut flowers to an oxytocin solution and / or a variant and / or derivative thereof.

Described is a method for vegetative propagation of plants by exposing a plant material to an oxytocin solution and / or a variant and / or derivative thereof.

The invention discloses an efficient oxytocic for hippocampus in the late pregnancy period and an oxytocic method of the efficient oxytocic. Research verifies that the odinagogue taking prostaglandin E2 as a main active component can rapidly induce the hippocampus to give birth in the late pregnancy (take effect within 60 minutes after odinagogue), and the odinagogue time is remarkably shortened. The juvenile fish produced by the method has independent viability, has no significant adverse effect on the sea horse with incomplete embryonic development, can effectively improve the mature fry acquisition rate when the embryonic development condition is unknown, reduces the fry loss in the culture process, and is beneficial to sea horse resource protection and industrial layout optimization.

Described herein is the use of nasally-administered oxytocin-based therapeutics to improve cognitive control in individuals with attention-deficit / hyperactivity disorder (ADHD).

The invention relates to steroids and / or functional analogues thereof for use in a method of treating an individual suffering from sexual dysfunction. Said steroids may be combined with an effective dosage of oxytocin and / or a functional analogue thereof.

The present application relates to a kind of intermediate compounds of novel oxytocin analogues, novel oxytocin analogues and preparation method, pharmaceutical composition and purposes thereof.The intermediate compound has the structure shown in formula (IV);Oxytocin analogues are compounds with the structure shown in formula (I);The preparation method of compound includes: the thiol alkene reaction of intermediate compound shown in formula (IV) is carried out so that the compound shown in formula (I);Pharmaceutical composition includes the compound shown in formula (I).The compound of the present application can effectively promote breast lactation and prevent or treat induced labor hemorrhage and postpartum hemorrhage, and has longer half-life and lower EC 50 value.

The present document relates to the field of agriculture and a method for stimulating germination of plants. More specifically, the present document relates to a method for seed soaking of seeds to stimulate their germination, a composition for such use and seeds after seed soaking. The method comprises soaking the seeds in an aqueous solution comprising oxytocin, a fragment thereof or a variant thereof, wherein the seeds are not allowed to germinate in the oxytocin solution. The result shows that this results in a stronger growth enhancing effect on the seeds.

To provide a technique for supporting to select daily necessities that are daily used by an infant.SOLUTION: A selection support system for infant daily necessities includes evaluation value acquisition means for acquiring a tactile evaluation value of daily necessities being used daily by an infant and / or a skin state evaluation value of the infant from a foster parent, selection support item determination means for determining a type of daily necessities for supporting selection in accordance with the level of the evaluation value, oxytocin prediction value calculation means for calculating a prediction value of an oxytocin amount of the infant from the evaluation value, support information processing means for acquiring information a selection support item having an evaluation value that exceeds an evaluation value acquired from the foster parent of the infant from a database storing the tactile evaluation value of the daily necessities and / or the skin state evaluation value information by using the evaluation value, calculating an oxytocin prediction amount of the selection support item, and generating support information about the selection support item including a difference between the calculated oxytocin prediction value of the infant and the oxytocin prediction value of the selection support item, and transmission means for transmitting the support information about the selection support item.SELECTED DRAWING: Figure 1

In an embodiment, a method of treating visual snow syndrome is disclosed. The method includes administering a therapeutically effective amount of oxytocin, which may be present with a thickener, in a suitable form to the upper nasal cavity of an individual. A pharmaceutical composition of oxytocin, which may include a thickener, for intranasal delivery for treating visual snow syndrome is also disclosed.

Disclosed are methods and compositions for the treatment of autism spectrum disorder, related disorders and symptoms of such disorders, comprising co-administration of an oxytocin peptide and magnesium ions. Co-administration of an oxytocin peptide and magnesium ions results in a synergistic or enhanced effect on reducing social and communication deficits in a patient suffering from an autism spectrum disorder.

The invention discloses a sea urchin seed gall oxytocin agent and a preparation method and application thereof, and belongs to the technical field of sea treasure seedling cultivation in the marine aquaculture industry. The preparation method of the sea urchin seed gall oxytocin agent is: garlic is mixed with disinfected seawater, crushed, filtered, and the filtrate is taken to obtain the sea urchin seed gall oxytocin agent. The sea urchin seed gall oxytocin agent uses natural product garlic as its raw material, is non-toxic to the seed gall after induced ...

The present application relates to the technical field of aquaculture, and particularly relates to an artificial breeding method of Cottus hangi in Xingkai Lake. The present application uses LRH-A2 and HCG combination oxytocin to reasonably inject female parent fish and male parent fish, especially to twice injection of female parent fish, and strictly controls injection dose of each injection and reasonable control time interval, which not only can efficiently induce labor, but also can reach 95% of the female parent fish induction efficiency, and can obtain good ovum and semen, so that the ovum can be better fertilized, the quality of the fertilized ovum is improved, the hatching rate is improved, the stress of the parent fish is reduced, and the death of the parent fish is reduced. The present application improves the physical fitness of the parent fish through reasonable parent fish cultivation, and combines reasonable artificial induction operation and post-production nursing measures, so that the post-production death of the parent fish is reduced from multiple aspects, and the post-production survival rate of the parent fish is significantly improved, so that the repeated cultivation cost of the parent fish is reduced.