42 results about "Oxytocin" patented technology

The invention relates to steroids and / or functional analogues thereof for use in a method of treating an individual suffering from sexual dysfunction. Said steroids may be combined with an effective dosage of oxytocin and / or a functional analogue thereof.

The application relates to the technical field of animal models, in particular to a modeling method and an evaluation method of an animal menstrual dysmenorrhea model and application, wherein the animal with removed ovaries is injected with estrogen, progesterone and oxytocin, the pharmacological injection of progesterone can reduce the harm and mortality rate of the animal caused by the implantation and removal of a progesterone release body in the prior art, the surgical stress of the animal is reduced, the injection time of the progesterone in the application is 7-9 days, and the animal menstrual dysmenorrhea model is obtained after the progesterone is withdrawn for 16 hours; after evaluation by the evaluation method, compared with the non-menstrual process of the dysmenorrhea model in the prior art, the animal menstrual dysmenorrhea model can better simulate the pathophysiological process of human dysmenorrhea, promote the development of clinical treatment, and effectively help patients to relieve pain.

A formulation (12) that creates a hormonal response in the body through a topical application. The topical formulation (12) contains botanicals in the form of jasmine flower extract and carob fruit extract. The botanicals are mixed with phospholipids and peptides to promote the absorption of the botanicals into the skin. Once applied to the skin, the jasmine flower extract and the carob fruit extract induce a hormonal response in the body. The hormonal response stimulates the oxytocin neural pathways in the body. This causes the body to believe that oxytocin is present, therein triggering the release of oxytocin within the body. The presence of the oxytocin facilitates physical and pro-social psychological improvements that include an improved libido, improved self-esteem, and improved self-confidence.

The invention discloses application of oxytocin to preparation of a medicine for preventing and treating postoperative cognitive impairment and the medicine. The invention discloses a mechanism of the oxytocin for preventing or treating the postoperative cognitive impairment for the first time, finds that the oxytocin can promote the expression of PI3K / Akt / mTOR pathway related protein in the hippocampal brain region and relieve the activation of microglial cells in the hippocampal brain region for the first time, and can prevent or treat the postoperative cognitive impairment by being locally administrated to the hippocampal brain region. The invention provides the application of oxytocin in the medicine for preventing or treating the postoperative cognitive impairment, and provides a new thought for the medicine for preventing or treating the postoperative cognitive impairment.

The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.

The application provides an application of a traditional Chinese medicine preparation in preparation of a drug for treating dysmenorrhea, and an active ingredient of the traditional Chinese medicine preparation is prepared from liquorice, asarum, cassia twig, angelica, white peony root, common sage and chuanxiong. The traditional Chinese medicine preparation provided by the application fuses multi-dimensional treatment strategies of warming meridians, nourishing blood, regulating qi and dredging collaterals, and can cover different TCM syndrome types such as cold coagulation and blood stasis, qi stagnation and blood stasis and qi and blood deficiency. Pharmacological experiments show that for dysmenorrhea rats of the cold coagulation and blood stasis type, the traditional Chinese medicine preparation of the application can reduce the sensitivity of the uterus caused by benzoic acid estradiol and inhibit the writhing reaction of the rats caused by oxytocin, which indicates that the traditional Chinese medicine preparation of the application has the effect of treating dysmenorrhea.

Combination therapies comprising oxytocin and gonadotropin releasing hormone are provided. The combinations can be used to treat aging-related neurological diseases or disorders. In addition, downstream effectors of OXT-GnRH combination, including hypothalamic stem / progenitor cells-derived EVs and vesicles containing or loaded with PTMS, can be used to treat aging-related neurological diseases or disorders.

Failures in establishing trust during international conflict negotiations frequently result in warfare, as ideological differences often cannot be resolved through rational discourse alone. Empathy between opposing parties is essential for building trust, and oxytocin is recognized for its critical role in facilitating empathy, trust, inter-brain synchrony, and cooperative decision-making. However, prevailing scientific studies typically do not differentiate between the cis and trans isomers of oxytocin, despite evidence that only the trans isomer is pharmacologically active. The present invention provides methods for the separation and quantification of oxytocin isomers, with particular emphasis on the trans isomer's function in social synchrony and decision-making within conflict negotiation contexts. Additionally, the invention explores the role of extremely low frequency electromagnetic radiation permeating the human central nervous system interconnecting neurochemical changes among groups. These advances clarify the unique neuropeptide functions of oxytocin and enhance understanding of its impact on cooperation and conflict resolution.

Described herein is the use of nasally-administered oxytocin-based therapeutics to improve cognitive control in individuals with attention-deficit / hyperactivity disorder (ADHD).

The present document relates to the field of agriculture and a method for stimulating germination of plants. More specifically, the present document relates to a method for seed soaking of seeds to stimulate their germination, a composition for such use and seeds after seed soaking. The method comprises soaking the seeds in an aqueous solution comprising oxytocin, a fragment thereof or a variant thereof, wherein the seeds are not allowed to germinate in the oxytocin solution. The result shows that this results in a stronger growth enhancing effect on the seeds.

In an embodiment, a method of treating visual snow syndrome is disclosed. The method includes administering a therapeutically effective amount of oxytocin, which may be present with a thickener, in a suitable form to the upper nasal cavity of an individual. A pharmaceutical composition of oxytocin, which may include a thickener, for intranasal delivery for treating visual snow syndrome is also disclosed.

The present application relates to the technical field of aquaculture, and particularly relates to an artificial breeding method of Cottus hangi in Xingkai Lake. The present application uses LRH-A2 and HCG combination oxytocin to reasonably inject female parent fish and male parent fish, especially to twice injection of female parent fish, and strictly controls injection dose of each injection and reasonable control time interval, which not only can efficiently induce labor, but also can reach 95% of the female parent fish induction efficiency, and can obtain good ovum and semen, so that the ovum can be better fertilized, the quality of the fertilized ovum is improved, the hatching rate is improved, the stress of the parent fish is reduced, and the death of the parent fish is reduced. The present application improves the physical fitness of the parent fish through reasonable parent fish cultivation, and combines reasonable artificial induction operation and post-production nursing measures, so that the post-production death of the parent fish is reduced from multiple aspects, and the post-production survival rate of the parent fish is significantly improved, so that the repeated cultivation cost of the parent fish is reduced.

The invention discloses a method for evaluating the analgesic effect of angelica sinensis stomachache dropping pills, belongs to the technical field of efficacy evaluation, and aims to solve the problem that no scientific method is provided for efficacy verification of dysmenorrhea traditional Chinese medicine preparations in the formula of angelica sinensis. The method comprises the steps of experimental mouse selection, acetic acid body twisting model test, hot plate pain model test and xylene inflammation model test. Selecting an experimental rat, and testing the primary dysmenorrhea model constructed by estradiol and oxytocin. The method comprises the following steps: constructing an analgesic effect evaluation model, and verifying analgesic and anti-inflammatory effects of angelica sinensis stomachache relieving; pharmacodynamic mechanism analysis is further carried out on the angelica sinensis stomachache dropping pill for simulating primary dysmenorrhea, it is revealed that the content of serum E2, IL-6, PROG, beta-EP and TNF-alpha of primary dysmenorrhea model rats treated by the angelica sinensis stomachache dropping pill has an adjusting effect, the effect of relieving dysmenorrhea can be achieved, the inflammation effect can be relieved by inhibiting NF-kappa B and MAPK channels, and the pain behavior can be relieved.

The invention discloses a method for increasing the survival rate of a pelteobagrus fulvidraco female parent in the breeding process, and relates to the technical field of methods for increasing the survival rate of the pelteobagrus fulvidraco female parent in the breeding process. S2, according to the fish body length of the pelteobagrus fulvidraco female parent, determining the length of the part, inserted into the fish body, of a needle of an injector, and then injecting an oxytocin compound solution into the pelteobagrus fulvidraco female parent through the injector for spawning induction. The problems that in the prior art, body injury and infection are caused by injection and manual egg squeezing, viscera are damaged due to improper operation during injection, and the survival rate of female parents is low are solved.

This invention discloses a mouse experimental method for detecting the tissue distribution of exogenous oxytocin, belonging to the field of biotechnology. Specifically, oxytocin is injected into or nasally sprayed into oxytocin knockout mice, and body tissues, including but not limited to brain tissue, mammary gland tissue, blood, heart tissue, uterine tissue, bone tissue, and muscle tissue, are collected at different time points. The tissue distribution and content of oxytocin are then detected using liquid chromatography-mass spectrometry (LC-MS / MS). This experimental method allows for a wider range of experimental samples, not just focusing on brain tissue and blood; it also has higher sensitivity and stronger specificity; and by utilizing oxytocin gene knockout mice, it eliminates the influence of endogenous oxytocin, providing certain assistance for subsequent animal experiments and clinical research on oxytocin.

The invention relates to a preparation method of a stable rat model for primary dysmenorrhea with syndrome of cold coagulation and blood stasis, belongs to the technical field of animal model construction, and particularly relates to a construction method of a rat model for primary dysmenorrhea according with the pathogenesis characteristics of cold coagulation and blood stasis in traditional Chinese medicine. The model simulates the pathological process of cold evil invasion and uterus stasis and combines a modern medical hormone intervention means to realize the construction of a'disease and syndrome combined 'animal model, and is mainly used for the anti-dysmenorrhea mechanism research and drug screening of traditional Chinese medicine compound, acupuncture and other therapies. The adopted preparation method comprises the steps that 0.4 mg of estradiol benzoate is subcutaneously injected to each rat every day for 12 days, the injection dosage of the first day and the injection dosage of the last day are increased to 2 times, the rats are placed in the environment of-20 DEG C after injection is completed, epinephrine is injected twice every day from the 6th day of molding, and 2 U of oxytocin is injected to each rat intraperitoneal cavity 24 hours after the epinephrine is injected for the last time. The animal model obtained through the method is stable in phenotype and good in repeatability, compared with pure cold or pure irritation, more remarkable pain behaviors and biochemical changes can be obtained in a short period through combination with epinephrine, and pharmacodynamic screening is facilitated.

The invention relates to a combination of testosterone and / or a functional analogue thereof and oxytocin and / or a functional analogue thereof for administration to subjects in need thereof for improvement of a cognitive disorder, sexual dysfunction, or mood disorder that can advantageously be applied with Repetitive Transcranial Magnetic Stimulation (rTMS) and / or cognitive training.

The application provides a kind of based on organoid mediated drug delivery system and its application, utilize by prolactin and oxytocin stimulate mammary gland organoid has lactation function and contains a large number of lipid droplets lactation mammary gland organoid, drug-loaded organoids obtained by co-incubation of lactation mammary gland organoid and antitumor prodrug can realize efficient loading of antitumor prodrug, lactation mammary gland organoid lactation or lipid droplet lipolysis will load drug controllable release.The drug-loaded organoids provided by the application can effectively inhibit postoperative recurrence of tumor, and can promote regeneration and repair of postoperative breast tissue;The drug delivery and tissue regeneration mediated thereby can be extended to various organoids, thereby achieving treatment of various tumors and postoperative tissue repair, and having wide application prospects in tumor treatment and tissue regeneration.

In some aspects, disclosed herein are methods and compositions for treatment or prevention of cerebral palsy using fibroblasts or derivatives thereof. Disclosed herein are fibroblasts and derivatives thereof capable of inducing neurogenesis and / or reducing inflammation in a subject. In some cases, the disclosed methods comprise use of conditioned fibroblasts. Fibroblasts may be conditioned with agents capable of enhancing therapeutic efficacy, for example oxytocin and / or human chorionic gonadotrophin (hCG).

The invention belongs to the technical field of biology, and discloses an application of Compound C in inhibition of uterine contraction of sheep, the Compound C significantly reduces expression of autophagy related genes LC3, BECN1, ATG5 and ATG7 by regulating an AMPK / mTOR signal channel, further inhibits autophagy of sheep uterine smooth muscle cells, and realizes targeted inhibition of uterine contraction. The optimal concentration of the Compound C in the preparation is 10 <-6 > mol / L, the administration dosage is 0.01 mg / kg of sheep body weight, the administration mode is intramuscular injection, and the Compound C can be combined with oxytocin to reverse the uterine contraction promoting effect of oxytocin. Cell experiments and animal experiments prove that the Compound C can improve uterine smooth muscle cell ultramicrostructure disorder, reduce autophagosome formation, delay the recovery speed of uterine horn of postpartum sheep, effectively inhibit abnormal uterine contraction and provide a new strategy for pregnancy maintenance and abortion reduction, and the action is milder.

The present disclosure provides compositions and methods for using oxytocin antagonists such as compounds of substituted pyrrolidine-3-ketoxime derivatives of formula (I) in the treatment of subjects receiving embryo transplantation therapy. The compositions and methods of the present disclosure may be used to administrate an oxytocin antagonist to a subject, including (3Z, 5S)-5-(hydroxymethyl)-1-[(2 '-methyl-1, 1'-biphenyl-4-yl) carbonyl] pyrrolidin-3-one O-methyl oxime, and the like, in particular, to a subject. The present invention relates to a method for improving endometrial receptivity and reducing the likelihood of embryo transfer failure and abortion after, for example, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) embryo transfer procedures. (Formula I)

The invention relates to the technical field of biochemical detection, in particular to a method for determining the content of oxytocin in a sample through liquid chromatography-tandem mass spectrometry. The method at least comprises the following steps: (1) providing a standard substance (standard substance) and obtaining a standard curve equation: preparing a standard solution, and detecting the standard solution by using a liquid chromatography-tandem mass spectrometer to obtain the standard curve equation for calculating the oxytocin content in a sample; (3) pre-treating a sample to be detected; and (4) detecting a sample to be detected: detecting the sample to be detected by using a liquid chromatography-tandem mass spectrometer, and substituting a detection result into the standard curve equation obtained in the step (1) to obtain the content of oxytocin in the sample to be detected. According to the method, detection can be completed within 30 min, and the sensitivity is smaller than or equal to 1 pg / mL.

The application discloses a preparation method and application of efficiently obtaining solar long-spined sea star larvae and juveniles / larvae. The method comprises the following steps: distinguishing the development period and the male and female genders of gonads; injecting oxytocin, separately collecting eggs and sperms, adding active sperms in batches after the eggs are broken, and the quantity ratio of the sperms and the eggs is 50-100:1; controlling the temperature, salinity and pH during the hatching of the larvae, culturing under full or half light shielding, and stirring when the fertilized eggs gather; feeding the hatched larvae with small new moon-shaped algae, changing water and removing dead and abnormal individuals; increasing the amount of feed when the larvae develop into brachiolaria, adding an attachment base when 70% of the planktonic larvae develop into late-stage brachiolaria with a size of 1000mu m*600mu m, transferring the juveniles to living stones with benthic coral algae after metamorphosis, and culturing until the long-spined sea star larvae are harvested. The application significantly improves the survival rate and metamorphosis rate of the planktonic larvae, and efficiently obtains a batch of larvae and juveniles / larvae in a short time.

The present invention provides cyclic oligopeptides and methods for using the same. The cyclic oligopeptides of the invention are analogues of oxytocin wherein the disulfide linkage between Cys1 and Cys2 are replaced with a more stable amide bond. The cyclic oligopeptides of the invention can also include a glycoside to increase blood-brain barrier penetration. In particular, the cyclic oligopeptide of the invention is of the formula: (A) (SEQ ID NO:2) where one of AA1 or AA6 is an amino acid having a carboxylic acid side-chain and the other is a carboxylic acid having an amine functional group on the side-chain such that X1 and X2 together form an amide bond; and each of AA2-AA5 and AA7-AA11 is independently natural or unnatural amino acids with at least one, typically at least two, often at least three, more often at least four, and most often at least five of which is an amino acid that is present in the corresponding position of oxytocin.

The present invention relates to a composition comprising a probiotic composition comprising a Lactobacillus salivarius strain and a Lactobacillus gasseri strain. The invention further relates to the nutraceutical and therapeutical uses of such compositions in oxytocin-related neuropsychiatric disorders, in particular autism or anxiety related disorders selected from depression and eating disorders.

This invention relates to a method for regulating the late autumn breeding of mandarin fish, belonging to the field of artificial fish breeding in aquaculture technology. The operation of this invention is as follows: (1) Inducing spawning in spring by injecting a high dose of a single oxytocin into the mandarin fish parent stock; (2) Under the action of the high dose of the single oxytocin, partial spawning is completed, achieving an average spawning volume per female fish of 20%-30% of the theoretical spawning volume in spring; (3) After spawning until the end of June, controlled feeding management is carried out to reduce the amount of feed, so that the fish are in a nutritional state of maintenance or slow growth; (4) In July and August, nutritional enhancement cultivation is carried out, and sufficient feeding is restored for a period of time before formal spawning to promote the rapid secondary development of the gonads of the parent mandarin fish; oxytocin is injected at a conventional effective dose to induce artificial insemination of the parent mandarin fish, resulting in concentrated spawning, achieving an average spawning volume per female fish of 80%-90% of the spawning volume in autumn. This invention can achieve the dual use of mandarin fish parent stock in one year through conventional hormone injection and feed management.

The disclosure provides means, methods, and compositions of preventing, reducing, and treating kidney failure through the administration of fibroblasts, modified fibroblasts, and / or products derived from fibroblasts. The disclosure may also concern administration of fibroblasts prior to, concurrent with, or subsequent to administration of a nephrotoxic agent results in production of renal function. In some embodiments, fibroblasts are enhanced for augmentation of nephron-regenerative properties through culture under means including hypoxia, histone deacetylase inhibitor treatment, oxytocin, and / or DNA methyltransferase inhibitors.

The invention discloses a breast pump simulating sucking of infants, and relates to the technical field of breast pumps, the breast pump simulating sucking of infants comprises a milk bowl, a breast pump main machine and a bra structure, the breast pump main machine and the bra structure are respectively connected with the milk bowl, the bra structure is provided with a bra, and the bra is provided with an elastic sucking-simulating lining air bag assembly. The breast pump main machine comprises a sealing shell and an air source device arranged in the sealing shell, an air conveying channel enabling the air source device to be communicated with the elastic sucking-imitating lining air bag assembly is arranged between the sealing shell and the elastic sucking-imitating lining air bag assembly, and particularly, the elastic sucking-imitating lining air bag assembly is arranged at the position of a breast cover. The breast pump comprises an inner lining upper lip and an inner lining lower lip, the breast pump can better simulate the sucking action of a baby during lactation, when the air source device inflates or deflates the air bag assembly through the air conveying channel, the inner lining upper lip and the inner lining lower lip can expand or contract, the effect similar to the sucking effect of the baby is generated, secretion of oxytocin can be promoted, and the lactation phenomenon is generated.