342results about How to "The synthesis process is simple" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The invention provides a method for preparing lithium iron manganese phosphate from waste lithium iron phosphate and application, and relates to the technical field of lithium ion batteries. Specifically, the method comprises the following steps: fully mixing a positive electrode of waste lithium iron phosphate, a manganese source, a phosphorus source, a lithium source and a carbon source in water, and sequentially grinding, drying and sintering to obtain the lithium iron manganese phosphate. According to the invention, waste lithium iron phosphate is taken as a raw material, lithium, manganese and phosphorus elements are supplemented, and lithium iron manganese phosphate with excellent performance is synthesized by using a high-temperature solid-phase method; according to the method, the waste lithium iron phosphate does not need to be subjected to any heat treatment or chemical treatment, the synthesis process is simple, operation is easy, the production cost is low, the method efficiency is high, the recovery rate of waste materials is high, meanwhile, high-value battery-grade lithium iron manganese phosphate can be obtained, and good application prospects are achieved.

The invention belongs to the field of all-solid-state lithium ion battery positive electrode materials, and particularly relates to an amorphous-state high-ion-conductivity positive electrode material, a preparation method and application of the amorphous-state high-ion-conductivity positive electrode material in an all-solid-state lithium ion battery, and the chemical composition general formula of the positive electrode material is LixFeOClFx, xlt; liF and FeOCl raw materials in a corresponding proportion are synthesized by a high-energy ball milling method to obtain the LiF / FeOCl composite material. The material is mainly composed of an amorphous phase and has isotropy, and it is ensured that an efficient and stable ion transmission channel can be constructed under the cold pressing condition. The amorphous high-ionic-conductivity lithium iron oxide chlorine fluorine-based positive electrode material provided by the invention has high ionic conductivity, stable capacity output, good rate capability, excellent machining performance and low-humidity air stability, and is used as an all-solid-state lithium ion battery positive electrode material; meanwhile, the material is low in synthesis raw material cost and simple in synthesis process, and has a good industrial amplification prospect.

The invention discloses an additive for modifying a lithium battery positive electrode material and a preparation method and application thereof, and belongs to the technical field of lithium ion batteries. The problems that an existing lithium battery positive electrode material is unstable in air, high in total alkali residue and poor in high-temperature stability, and active lithium is consumed due to long circulation are solved. The expression of the additive is LiaMgbMec( PO4) dYe, Me represents a transition metal element, Y represents an anion, a is greater than 0 and less than or equal to 2, b is greater than 0 and less than or equal to 1.5, c is greater than or equal to 0 and less than or equal to 0.4, d is greater than 0 and less than or equal to 1, and e is greater than or equal to 0 and less than or equal to 0.4. The additive is rich in magnesium, so that the positive electrode material can provide effective structural support during lithium ion intercalation / deintercalation, and high-temperature cycle stability is provided; by doping the transition metal element, irreversible lithium loss caused by formation of an SEI film can be counteracted during intercalation / deintercalation of lithium ions, so that the total capacity and the energy density of the battery are improved; the added anion group can reduce the residual alkali of the positive electrode material and reduce the gas production of the lithium battery under high voltage.

The invention belongs to the technical field of molecular probes and nano textile materials, and particularly relates to a fluorescent probe for detecting metal palladium, a fluorescent nanofiber membrane and a preparation method and application of the fluorescent nanofiber membrane. The fluorescent probe for detecting metal palladium provided by the invention takes benzopyran as a fluorescent parent nucleus and allyl as a recognition site, is novel in structure, and can realize effective detection of elemental palladium in the environment. Furthermore, according to the fluorescent nanofiber membrane for detecting the metal palladium, the electrostatic spinning technology and the fluorescent probe are effectively combined, and rapid detection of the elemental palladium can be achieved through the fluorescence opening performance after the fluorescent probe reacts with the metal palladium. Besides, the fluorescent nanofiber membrane has the characteristics of simplicity in preparation, low cost and reusability, can provide a powerful tool for rapid, simple and convenient detection of palladium-containing elementary substance pollutants in the environment, and has an extremely wide application prospect in the field of metal palladium detection.

The invention discloses a bimetallic MOF material and a preparation method and application thereof. The preparation method comprises the following steps: dispersing organic lanthanum salt, organic ferric salt and organic ligand in an organic solution, stirring, and carrying out ultrasonic treatment to obtain a mixed solution; adding alkali into the mixed solution, and then carrying out ultrasonic treatment to obtain a precursor; heating the precursor in an oil bath, and naturally cooling after the reaction is finished; the reactants are separated, dried and ground into powder, and the bimetallic MOF material is obtained. The bimetallic MOF material has adsorption and fluorescence detection functions. The bimetal MOF material prepared by the method disclosed by the invention has very high adsorption capacity on fluorine ions in water, and the maximum adsorption capacity of the bimetal MOF material reaches 400.860 mg / g. And the detection limit of the linear range is 0-80 [mu] M.

The invention discloses a water-resistant broussonetia papyrifera leaf protein wood adhesive and a preparation method thereof, and the water-resistant broussonetia papyrifera leaf protein wood adhesive comprises the following components by weight: 2.4 parts of a protein denaturant I; 0.3 part of a protein denaturant II; 120 parts of a dispersion medium; 30 parts of a broussonetia papyrifera leaf protein extract; and 30 parts of a cross-linking agent. The preparation method comprises the following steps: mixing the protein denaturant I, the protein denaturant II and the dispersion medium, fully dissolving, adding the broussonetia papyrifera leaf protein extract, heating at constant temperature, adding the cross-linking agent into the mixture, and continuously heating at constant temperature for reaction to obtain the water-resistant broussonetia papyrifera leaf protein wood adhesive. The wood adhesive is prepared by taking the broussonetia papyrifera leaf protein as a main raw material, a new raw material source of the biomass-based wood adhesive is developed, the problems of raw material greenization, low cost and sustainable supply are solved, and the economic utilization value of broussonetia papyrifera resources is also remarkably improved; the preparation method is simple, and the prepared broussonetia papyrifera leaf protein wood adhesive has excellent water resistance, mechanical strength and comprehensive performance.

The invention relates to the technical field of flame-retardant materials, in particular to a vanillin-derived nitrogen-phosphorus synergistic flame retardant as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out aldehyde-amine condensation reaction on vanillin and p-phenylenediamine to generate a Schiff base intermediate with a characteristic group-C = N-; and carrying out addition reaction on the intermediate and reactive hydrogen connected with a phosphorus atom on 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, so as to obtain the vanillin-derived nitrogen-phosphorus synergistic flame retardant. The flame retardant obviously improves the flame retardant grade of the high polymer material under the condition of lower addition amount, does not release toxic and harmful gases in the combustion process, and meets the requirements of greenness and environmental protection. The flame retardant has good compatibility with high polymer materials such as thermoplastic polyurethane and the like. The preparation method of the flame retardant is controllable in reaction process, large-scale production is easy to realize, an innovative and feasible solution is provided for flame retardance of high polymer materials, and the flame retardant is expected to be widely applied to the fields of electronics, automobiles, buildings and the like.

The invention discloses a monoether amine modified nonionic waterborne epoxy emulsion as well as preparation and application thereof, and belongs to the field of waterborne industrial anticorrosive coatings. The monoether amine modified nonionic waterborne epoxy emulsion is prepared from the following raw materials: E-20 epoxy resin, dipropylene glycol monomethyl ether, ethylene glycol monobutyl ether, monoether amine, propylene glycol monomethyl ether, a nonionic epoxy emulsifier and deionized water. The nonionic waterborne epoxy emulsion disclosed by the invention is prepared by modifying monoether amine and emulsifying by adopting a nonionic emulsifier, and the prepared nonionic waterborne epoxy emulsion is uniform in appearance, free of mechanical impurities, less than or equal to 0.50 mu m in particle size and 7-8 in pH value.

The invention discloses a preparation method of a carbon fiber cloth coated SixFe1-xO2 nanorod material, which comprises the following steps: dissolving a silicon source and an iron source in a mixed solution of ethanol and ethylene glycol, adding hexamethylenetetramine and urea step by step, stirring and dissolving to obtain a mixed solution, then putting the mixed solution and carbon fiber cloth into a high-pressure reaction kettle together, and stirring for 30-60 minutes to obtain the carbon fiber cloth coated SixFe1-xO2 nanorod material. The preparation method comprises the following steps: adding a carbon fiber cloth coated SixFe1-x (OH) 4 nanorod material into a reaction kettle, reacting at a certain temperature in a constant-temperature drying box, then naturally cooling to room temperature, washing and drying to obtain the carbon fiber cloth coated SixFe1-x (OH) 4 nanorod material, putting the carbon fiber cloth coated SixFe1-x (OH) 4 nanorod material into a muffle furnace, and annealing in an air environment to obtain the carbon fiber cloth coated SixFe1 The synthesis process is simple, the cost is low, the requirement for equipment is low, the controllable degree is high, and the obtained product is uniform and novel in morphology, has high charging and discharging capacity and long cycle life as a flexible negative electrode material, and has wide application in the fields of flexible batteries, photoelectric devices and the like.

The invention discloses a novel polypeptide, a polypeptide derivative and application thereof, and belongs to the technical field of biological medicine. The invention specifically relates to a specific sequence, a discovery process, a specific anti-tumor type, a long-acting modification mode and application of the novel polypeptide. The tumors comprise one or more of brain glioma, neuroblastoma, head and neck cancer, esophagus cancer, thyroid cancer, lung cancer, liver cancer, kidney cancer, breast cancer, cervical cancer, uterine cancer, ovarian cancer, colon cancer, small intestinal cancer, ileocecum cancer, stomach cancer, bladder cancer, pancreatic cancer, prostate cancer, bile duct cancer, melanoma, sarcoma, myeloma, lymphoma and leukemia; the compound has the specific effect of inhibiting proliferation and / or metastasis of tumor cells, is wide in treatment spectrum and has important treatment value in various tumors.

The invention discloses a modified isocyanate prepolymer, a preparation method thereof and a degradable biological adhesive, and belongs to the technical field of medical adhesives. The preparation method comprises the following steps: firstly, continuously reacting alcohol with polyhydroxy acid at a certain temperature to obtain a polyester soft segment containing part of hydroxyl and carboxyl functional groups; and adding isocyanate or isocyanate and alcohol into the prepolymer, and reacting to obtain the modified isocyanate prepolymer. And mixing the modified isocyanate prepolymer with a curing agent to obtain the polyurethane biological adhesive. The curing agent is an unsaturated carbonyl compound modified amine curing agent or a polyamine modified polyphenol curing agent. The polyurethane adhesive is applied to adhesion of a wet tissue interface, and during application, the polyurethane biological adhesive is smeared to a tissue part needing to be adhered and sealed, and in-situ curing is realized. The process for preparing the isocyanate prepolymer is simple, and the polyurethane biological adhesive obtained by utilizing the isocyanate prepolymer is easy to degrade and good in wet adhesion.

The invention belongs to the technical field of veterinary drugs, and particularly relates to a 2, 3-disubstituted naphthoquinone compound as well as application and a preparation method thereof, the general formula of the 2, 3-disubstituted naphthoquinone compound is # imgabs0 #, and X is selected from C, NH, O and S; wherein when X is selected from C, an X-R1 substituent is represented as an aryl substituent; when X is selected from NH, R1 is selected from a hydrogen atom, C1-6 alkyl, C3-6 cycloalkyl, substituted aryl, substituted benzyl and substituted acyl; when X is selected from O, R1 is selected from a hydrogen atom, C1-6 alkyl, C3-6 cycloalkyl, substituted benzyl and substituted acyl; when X is selected from S, R1 is selected from C1-6 alkyl, substituted aryl and substituted benzyl; r2 is selected from C1-16 alkyl, substituted aryl, Ra-(CH2) n-, and Ra-CO-(CH2) n-; the series of compounds are novel in structure and good in antibody ectoparasite activity, are successfully applied to the field of veterinary drugs, and solve the long-standing problems of safety and toxicity; the synthesis process is simple, the conditions are mild, and various 2, 3-disubstituted naphthoquinone compounds can be efficiently prepared.

The invention relates to an organic silicon compatible macromolecular photoinitiator, the absorption wavelength of the initiator is not only suitable for LED light source polymerization, especially can effectively initiate the photopolymerization reaction of organic silicon resin, but also has good compatibility with the organic silicon resin, and simultaneously reduces the migration and volatilization of photolysis fragments in the photopolymerization process. The invention further relates to a method for preparing the organic silicon compatible macromolecular photoinitiator and application of the organic silicon compatible macromolecular photoinitiator in LED photopolymerization.

The invention discloses an expanded microcrystalline graphite / Fe2O3 / SnO2 lithium ion battery micro-nano negative electrode material as well as a preparation method and application thereof, and relates to the technical field of new material preparation and new energy. Comprising the following steps: by taking high-purity microcrystalline graphite as a raw material, preparing expanded microcrystalline graphite by adopting an oxidation method and an inert atmosphere heat treatment method, then preparing an expanded microcrystalline graphite / Fe2O3 composite material by adopting a water bath method and an air atmosphere heat treatment method I, and then preparing the expanded microcrystalline graphite / Fe2O3 / SnO2 composite material by adopting a hydrothermal method and the air atmosphere heat treatment method I for the negative electrode of the lithium ion battery. The ternary composite material has the first specific discharge capacity of 1539.9 mAh / g under the current density of 0.1 A / g, the first coulombic efficiency is 70.1%, and the ternary composite material still has the specific discharge capacity of 1003.2 mAh / g after 100 cycles. The expansion effect of the high-purity microcrystalline graphite is remarkable, the lithium storage capacity and the cycling stability of the lithium ion battery negative electrode material are remarkably improved by selecting and adding the nano metal oxide, and a new thought and a new method are provided for developing the high-performance lithium ion battery negative electrode material.

The invention relates to a preparation method and application of a lithium-rich manganese oxide positive electrode material with high capacity and long cycle stability, and the method comprises the following steps: mixing lithium acetate dihydrate, nickel acetate tetrahydrate, cobalt acetate tetrahydrate, manganese acetate tetrahydrate and citric acid monohydrate, adding into deionized water, uniformly stirring, adding oleic acid to prepare a precursor solution, and carrying out spray drying to prepare a precursor material; and carrying out heat treatment on the precursor material in an air atmosphere to prepare the lithium-rich manganese oxide positive electrode material Li < 1.2 > Ni < 0.13 > Co < 0.13 > Mn < 0.54 > O < 2 > with high capacity and long cycle stability. The lithium-rich manganese-based positive electrode material has the advantages that the lithium-rich manganese-based positive electrode material compositely modified by oleic acid and citric acid is simple in process, a spinel phase with high lithium ion conductivity is generated, and the lithium-rich manganese-based positive electrode material has high specific capacity and excellent cycle performance under high current density when being applied to a positive electrode of a lithium ion battery.

The invention relates to the technical field of lithium ion batteries, in particular to a sodium ion poly-cathode and anode material synthesized by a solid phase method and a preparation method thereof. The sodium ion polycathode and anode material is sodium ferric fluorophosphate (NFPF), the chemical composition of the sodium ferric fluorophosphate (NFPF) is Na < 4 + x > Fe < 3 + y > P4O12 + zF gamma, and x is greater than or equal to-0.1 and less than or equal to 0.1; y is in the range of-0.1 < = y < = 0.1; z is more than 0 and less than or equal to-1; 0 < gamma < = 2. The sodium ion polycathode and anode material-sodium ferric fluorophosphate (NFPF) prepared by the solid phase method has the advantages of high ion and electron conductivity, structural stability, easiness in synthesis of a pure phase and the like, is favorable for improving the performance of a battery and reducing the production cost, and has a wide application prospect.

The invention discloses a preparation method of a dotenorad key intermediate (a compound shown as a formula I), which comprises the following steps: alkalizing 2-aminothiophenol to generate 2-aminothiophenol sodium salt, carrying out cyclization reaction on the 2-aminothiophenol sodium salt and formaldehyde, and finally condensing the 2-aminothiophenol sodium salt and 3, 5-dichloro-4-methoxybenzoyl chloride to obtain the dotenorad key intermediate (the compound shown as the formula I).

The invention belongs to the field of lipid delivery carriers, and particularly relates to a cationic lipid compound as well as a preparation method and application thereof. The cationic lipid compound is designed and synthesized, the lipid nanoparticle composition formed by the cationic lipid compound has the advantages in at least one aspect of the aspects of encapsulation efficiency, biological safety, transfection efficiency protein expression in cells and organisms and the like, and the problems existing in the prior art are solved. The method has non-important significance on development of gene therapy products. In order to improve the drug delivery effect of a gene vector and simplify the synthesis steps of the gene vector, the invention provides a cationic lipid compound as well as a preparation method and application thereof. The cationic lipid compound has positive electricity and can enter cells more easily, so that drugs are better delivered, a better treatment effect is generated, and the cationic lipid compound is simple to synthesize and easy to prepare and has practical application value.

The invention relates to a preparation method and application of metal-doped calcium manganese ore manganese dioxide. The method comprises the following steps: dissolving manganese salt in deionized water to prepare a solution; under stirring, dropwise adding an alkali solution into the obtained solution, after a solid is separated out, adding metal salt and magnesium sulfate, uniformly mixing, then slowly adding an oxidizing agent, and stirring to obtain a black precipitate; washing the black precipitate with water, soaking the black precipitate in a magnesium chloride solution, washing again, transferring the obtained solid and magnesium chloride into a high-pressure kettle with a polytetrafluoroethylene lining, heating, cooling, centrifuging, washing and drying the obtained precipitate to obtain metal-doped calcium manganese ore manganese dioxide; the original tunnel structure of the calcium manganese ore manganese dioxide cannot be changed by doping the ions such as Zn < 2 + >, Co < 2 + >, Ni < 2 + >, Al < 3 + >, Fe < 3 + > and Eu < 3 + > into the calcium manganese ore manganese dioxide, the doped metal active ions can be combined with the calcium manganese ore manganese dioxide, the electrochemical performance of the material in the water-based zinc ion battery can be effectively improved, and the material has important significance on research of the water-based zinc ion battery.

The invention relates to a calcium-tin co-doped O3 type sodium ion battery positive electrode material and a preparation method thereof. The chemical formula of the positive electrode material is Na (1-2x) CaxNi (0.33) Fe (0.33) Mn (0.33-y) SnyO2, x is more than 0 and less than or equal to 0.025, y is more than 0 and less than or equal to 0.02, and the subscript is the theoretical atomic ratio of each element; the preparation method comprises the following steps: mixing and grinding a sodium source, a calcium source, a nickel source, an iron source, a manganese source and a tin source to obtain a precursor mixture; and heating to 400-500 DEG C, calcining, heating to 800-1000 DEG C, and calcining for 10-15 hours to obtain the calcium and tin doped O3 type sodium ion battery layered oxide positive electrode material. The material has the discharge specific capacity equivalent to that of the original material, the structural stability and the cycling stability in the cycling process are improved, and the service life of the battery is prolonged.

The invention provides a heat-conducting vegetable protein-based composition, a heat-conducting vegetable protein adhesive as well as a preparation method and application of the heat-conducting vegetable protein-based composition and the heat-conducting vegetable protein adhesive. The heat-conducting vegetable protein-based composition provided by the invention is prepared by ball-milling raw materials including a heat-conducting filler, modified vegetable protein and (3-(methacrylamido) propyl) trimethyl ammonium chloride in a mass ratio of 1: (0.3-5): (0.03-1) for 15-25 hours. The heat-conducting vegetable protein adhesive comprises the following raw materials in percentage by weight: 6-20% of the heat-conducting vegetable protein-based composition and 3-8% of a cross-linking agent, and further comprises 0.1-3% of a flame-retardant reinforcing agent on the basis of the heat-conducting vegetable protein-based composition and the cross-linking agent. The heat-conducting vegetable protein adhesive provided by the invention adopts the heat-conducting vegetable protein-based composition, has good cementing performance and water resistance, also has good heat conductivity, flame retardance and mildew resistance, is beneficial to preparation of multifunctional materials, and is beneficial to industrial application, especially in the field of artificial board industry.

The invention belongs to the technical field of metal-organic framework functional materials, and particularly relates to a nickel-based metal-organic framework material, a plasmon nickel-based metal-organic framework composite material and a synthesis method and application of the nickel-based metal-organic framework material and the plasmon nickel-based metal-organic framework composite material. According to the invention, chloroauric acid is directly reduced into gold nanoparticles by using the reducibility of the nickel-based metal organic framework material, and the gold nanoparticles are loaded on the nickel-based metal organic framework material, so that uniform dispersion and firm loading of the gold nanoparticles on the nickel-based metal organic framework material are realized. The method has the advantages of simple synthesis method, convenience in operation and no need of additional reducing agent, is easy for large-scale preparation, and has better market application value and development prospect. The prepared plasmon nickel-based metal organic framework composite material is used as a photoelectrocatalytic reaction catalyst to be applied to photoelectrocatalytic reduction of nitrate to prepare ammonia, and the catalytic performance is excellent.

The invention discloses a preparation method and application of a hyperbranched multi-arm star-shaped epoxy resin emulsifier, and relates to the field of waterborne epoxy emulsions. The preparation method of the hyperbranched multi-arm star-shaped epoxy resin emulsifier comprises the following steps: synthesizing a hyperbranched polyether hydrophobic core containing rich epoxy end groups from a polyhydroxy compound and a polyfunctional epoxy compound, and grafting methoxypolyethylene glycol to the hydrophobic core through hydroxyl epoxy-opening reaction. Compared with a traditional linear emulsifier, the hyperbranched emulsifier has the advantages that abundant active end groups can introduce a large number of hydrophilic chain segments to obtain better emulsifying capacity, sufficient reaction sites can be reserved to participate in curing of a system, and negative effects on a coating due to dissociation of the emulsifier are reduced.

The invention belongs to the technical field of organic synthesis, and discloses a synthesis method of a disulfide compound. According to the invention, under the catalytic action of 1, 4, 7, 10, 13, 16-hexaoxacyclo-octadecane, halogenated hydrocarbon, sodium sulfide and sulfur react at the temperature of 50-60 DEG C to prepare the disulfide compound. The synthesis method of the disulfide compound has the advantages of being simple in process, small in catalyst dosage, mild in reaction condition, high in production efficiency, low in production cost, convenient for industrial production and the like, in addition, the reaction yield of the synthesis method can reach 94.8%-96.6%, and the purity of the obtained target product reaches up to 97.9%-99.3%. The method can be applied to preparation of the disulfide compound, and the obtained disulfide compound can be further applied to the fields of biomedicine, agriculture, chemical industry and the like.

The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of aromatic diether dicarboxylic acid, which comprises the following steps: (1) under the protection of inert gas, adding aromatic diphenol, p-fluorobenzonitrile, basic carbonate and a solvent 1 into a reactor, and reacting at 120-150 DEG C for 10-20 hours to obtain aromatic diether dinitrile; and (2) adding aromatic diether dinitrile, alkali metal hydroxide and a solvent 2 into the reactor, reacting at 100-150 DEG C for 10-20 hours, neutralizing with inorganic acid until the pH value is 1-2, filtering, washing with water until the pH value is neutral, and drying to obtain the product. By selecting specific reaction raw materials and process conditions, higher yield is successfully realized at lower temperature, and the method is very suitable for industrial production of aromatic diether dicarboxylic acid.

The invention discloses tetraisononyl pyromellitate as well as a preparation method and application thereof. The tetraisononyl pyromellitate is obtained by carrying out esterification reaction on pyromellitic acid or pyromellitic anhydride and isononyl alcohol under the action of a catalyst. The raw materials used in the synthesis process of the tetraisononyl pyromellitic acid are safe, the cost is low, the synthesis procedures and steps are simple, and the synthesis method is suitable for industrial processing and production. The trioctyl trimellitate plasticizer can be used as one of substitutes of the trioctyl trimellitate TOTM plasticizer, and even is a better improved product.

The invention relates to a biotin receptor targeted photosensitizer or a pharmaceutically acceptable salt thereof, the biotin receptor targeted photosensitizer has a structure of the following general formula (I): # imgabs0 # (I), and a group R is a diamine derivative group of biotin and is defined in the specification. The invention further relates to preparation and application of the biotin receptor targeted photosensitizer and a medicine box containing the biotin receptor targeted photosensitizer.

The present invention provides a liquid cooling medium and a preparation method and application thereof, belonging to the field of chemical industry. The liquid cooling medium prepared by the preparation method provided by the present invention is a hydrofluoroolefin mixture, comprising two material components, CF3CF2CF2CH=CHCF3 and (CF3)2CFCH=CHCF3. The mixture is spontaneously generated in the preparation process, and there is no need to separate the two, and it can be directly used as a two-phase immersion liquid cooling medium. The preparation method of the present invention is of great significance for preparing candidate working fluids with excellent performance and stable quality for immersion cooling systems, optimizes the synthesis process of hydrofluoroolefins, and provides a full-process preparation process method for raw materials, intermediates and final products. The final product obtained has stable quality and excellent performance. The prepared liquid cooling medium has the advantages of efficient heat dissipation and temperature control, which can achieve the purpose of energy saving and consumption reduction.

The invention relates to the technical field of optical resin, and particularly discloses a synthesis process of polysiloxane resin with a low refractive index. The synthesis process comprises the following steps: taking amino double-terminated polydimethylsiloxane and isocyanate as main raw materials, feeding the amino double-terminated polydimethylsiloxane and the isocyanate according to a molar ratio of 1: (1-2), and reacting in an inert gas atmosphere to obtain the low-refractive-index polysiloxane resin. A target product can be obtained through direct reaction in a solvent-free state, the refractive index of the target product is controlled to be 1.41-1.44, the elongation at break can reach 200-400%, and the target product has excellent elasticity; the target product can be directly subjected to subsequent melt extrusion, is more environment-friendly compared with a solvent method, and is more suitable for manufacturing an elastomer multilayer optical film.