The invention relates to a neural network-based cloud intelligent machine system of cloud operation, data mining, the neural network, information security and the like. The system comprises a neural network-based computer structure, a generalized database structure and a data structure over software and hardware boundaries. The system provides and uses a plurality of novel technologies, including an algorithm engine structure, an instinctual neural network, information compression, a limited network protocol, a security system, a cross platform data structure and the like, wherein the computer system structure described in the invention can easily be over thousands times of the cluster computing power of a current top server, and break through the bottleneck of the computing capacity of a future cloud computing center. The system has immunization and self-healing ability, and is prevented from being attacked by virus hackers. The system grows and metabolizes like organisms, defines new constantly changing tasks, and completes upgrading and expansion, and can be applied to a large-scale information center, an out-sourcing enterprise management, E-business and other cloud computing centers.