The invention relates to a flexible array pressure measurement sensor based on piezoresistive effect. The sensor herein includes a row control circuit, a touch element sensing unit, a column control circuit, a same direction amplifier circuit, a filter circuit, a micro-control circuit and a control communication port which are successively connected, and also includes an equipotential shielding circuit. The row control circuit, the equipotential shielding circuit, and the column control circuit are connected to the micro-control circuit. The invention also discloses a measurement method. The method herein includes the following steps: representing the forces at different positions in the touch element sensing unit with variations of different resistances, a measurement point switching circuit selecting to connect different sensitive units to a signal modulation circuit through a row and column simulation circuit, converting the variation of the resistances of the sensitive units to voltages, and obtaining a pressure by calibrating the corresponding relationship between the voltages and voltages. According to the invention, the sensor and the measurement method herein, based on theplan for distributing the sensitive units in rows and columns, can measure the distributed force on the surface with a density of 22 point/cm<2>, and overcome the low density of pressure measurement sensors at home and abroad and too slow detection velocity.