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922 results about "High flux" patented technology

Multi-thread high-throughput data flow channel separation method and system based on zero copy

The invention belongs to the technical field of data transmission and processing, and discloses a zero-copy-based multi-thread high-throughput data stream channel separation method and system, and the method comprises the steps: directly writing a mixed data stream into a front-end buffer region configured as an annular structure through a data receiving module by adopting direct memory access; then, a multi-thread processing module dynamically allocates a plurality of processing threads from a thread pool to separate channel data in parallel, each thread adopts a zero copy algorithm based on pointer offset, positions the channel data in a memory, creates pointer reference and associates the channel data to a corresponding rear-end buffer area, and logic separation is achieved without physical copy; and finally, the data storage module efficiently writes the separated data into persistent storage in an asynchronous I / O mode. According to the method, zero-copy, multi-thread parallel and two-stage dynamic buffering strategies are combined, the data separation efficiency is remarkably improved, CPU occupation and memory bandwidth are greatly reduced, and the real-time performance and stability of high-throughput data processing are guaranteed.
Owner:CHINA JILIANG UNIV

Large-aperture spliced telescope adjusting device and adjusting method thereof

The invention belongs to the field of astronomical telescopes, and particularly relates to a large-aperture spliced telescope adjusting device and method, and the method comprises the steps: starting a light source module, providing a far-field illumination light beam for a spliced primary mirror, and carrying out the confocal adjustment of each sub-mirror through an adjusting mechanism according to the far-field illumination light beam; the light source switching module is used for providing a near-field illumination light beam for the spliced primary mirror, and the near-field illumination light beam is split into two separated sub light beams by the pyramid mirror after penetrating through a splicing seam of the spliced primary mirror; performing dispersion on all the sub-beams through a dispersion prism, and converging the dispersed sub-beams through an achromatic lens to form dispersion stripes; the phase difference of the dispersion fringes is extracted through the camera, and co-phase adjustment is carried out on the sub-mirrors through the adjusting mechanism according to the phase difference of the dispersion fringes. According to the invention, high-precision and high-flux spectral response calibration and co-phase detection of the large-aperture spliced telescope can be realized, so that reliable technical support is provided for construction and operation of a next-generation giant astronomical telescope.
Owner:CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI

Fast thermal neutron and gamma ray multi-mode detector

The invention discloses a fast thermal neutron and gamma ray multi-mode detector, and relates to the technical field of nuclear radiation detection, and the detector comprises a detector housing, and the interior of the detector housing is connected with a fast neutron detection unit, a thermal neutron detection unit and a gamma ray detection unit. The gamma ray detection unit is located between the fast neutron detection unit and the thermal neutron detection unit; and an insulating separation unit is connected between two adjacent detection units. The detector can detect fast neutrons, thermal neutrons and gamma rays in the same equipment at the same time, structures such as a cadmium thermal neutron shielding layer and a fast neutron moderation layer do not need to be added, the size of the detector can be greatly reduced, and the detector has the advantages of being compact in structure, stable in performance, wide in energy measurement range, wide in fluence rate measurement range and the like. The ultrahigh-energy high-flux neutron measurement with the neutron energy at least covering # imgabs0 # and the neutron fluence rate at least covering # imgabs1 # can be realized.
Owner:NUCLEAR POWER INSTITUTE OF CHINA

Turntable high-throughput Raman testing device

The utility model relates to the technical field of optical detection, and discloses a turntable high-flux Raman testing device which comprises a base, a detector is fixedly connected to one side of the top of the base, a Raman probe is fixedly connected to one side in the detector, a first motor is fixedly connected to one side in the base, and a second motor is fixedly connected to one side in the base. And the output end of the motor I is fixedly connected with a solid double-layer rotating disc. According to the utility model, the motor I drives the rotating disc to rotate, so that the transparent sample bottles are moved to rotate along the rotating disc, and the transparent sample bottles pass through the Raman probes one by one for chemical component analysis. The rotation of the turntable is controlled through a control program, and the probe is controlled to collect Raman signals of samples, so that full-automatic component analysis of multiple samples is realized. The problem that a measurement result is inaccurate due to the fact that a probe needs to be moved due to the fact that the surface of liquid is uneven when a perforated plate is used for collecting a sample for testing is solved, and the measurement accuracy and efficiency are improved.
Owner:SUBPHOTONICS DETECTION (ZHUHAI) PTY LTD

High-flux and high-efficiency cell extrusion microfluidic system and particle introduction method

The invention relates to the technical field of microfluidics, in particular to a high-throughput and high-efficiency cell extrusion microfluidic system and a particle introduction method. And a closed-loop control system integrating real-time cell deformation sensing, dynamic parameter decision and physical extrusion and alternating electric field cooperative application is constructed. The chip is provided with an inlet shunting device, a micro-channel and a channel structure of a microelectrode. The method comprises the steps of real-time deformation image acquisition and analysis and dynamic extrusion parameter decision and cooperative application. The invention provides a high-flux and high-efficiency cell extrusion microfluidic system and a particle introduction method, and aims to solve the problems that the drug loading efficiency and the survival rate are difficult to consider due to heterogeneity in the existing cell extrusion technology and a physical extrusion and electroporation coordinated regulation strategy is lacked, so that personalized precise treatment of cells is realized, and the cell quality is improved. The drug loading efficiency, the cell survival rate and the high throughput are obviously improved.
Owner:HENAN UNIVERSITY OF TECHNOLOGY

Efficient water treatment system based on reverse osmosis membrane and control method

According to the efficient water treatment system based on the reverse osmosis membrane and the control method provided by the invention, gradient anti-pollution membrane arrangement and reconfigurable intelligent waterway design are creatively combined, so that a foundation is laid for high-flux and low-pollution operation from a physical structure; meanwhile, a full-closed-loop intelligent control system is constructed, and by fusing fuzzy logic, an optimization algorithm and a neural network prediction model, the system can integrate multi-dimensional information such as inlet water quality, membrane pressure difference and water yield, judge pollution risks in real time and adaptively and seamlessly switch among a high recovery mode, a segmented flushing mode and a prediction cleaning mode, so that the system is high in recovery efficiency and high in reliability. Meanwhile, parameters such as pump frequency and valves are dynamically optimized to find an optimal balance point of recovery rate and energy consumption; according to the invention, the recovery rate can be stably improved, the membrane pollution rate is greatly reduced, the chemical cleaning period and the service life of the membrane element are prolonged, and finally, the comprehensive operation and maintenance cost of the system is remarkably reduced while the water treatment efficiency and the water quality safety are improved.
Owner:JIUZHANG MEMBRANE (BEIJING) TECH CO LTD

On-orbit computing power cluster-oriented high-heat-flux heat dissipation system

The invention discloses a high-heat-flux heat dissipation system for an on-orbit computing power cluster, and belongs to the technical field of spacecraft heat control. The system is independent of a satellite conventional thermal control platform and is specially used for discharging waste heat of an AI calculation array. The system comprises a heat capture unit, a pumpless heat transfer unit and a foldable heat dissipation unit. The heat transmission unit comprises a micro-channel flexible pulsating heat pipe (such as a diamond film material), and the heat pipe spans a folding area and has the functions of structural connection and heat transmission, so that a thermal low-impedance independent channel relative to a satellite structure is formed. Through the design of removing a mechanical pump and removing a mechanical hinge, the problems of large weight, micro-vibration interference, high contact thermal resistance and the like of a heat dissipation system of the computing power satellite are solved, and preferential directional heat dissipation of high-flux heat is realized.
Owner:陈熙元

Cooling and packaging structure based on diamond-copper composite micro-channel

The invention relates to the technical field of semiconductor packaging and cooling, and particularly discloses a diamond-copper composite micro-channel-based cooling and packaging structure which comprises a packaging shell and a diamond-copper heat conduction plate with the bottom in floating lap joint through an elastic sealing ring. A plurality of heat exchange stand columns are integrally formed on the upper surface of the heat conduction plate, and the heat exchange stand columns are inserted into the containing counter bores of the packaging shell to form micro-channel annular gaps. A piezoelectric vibration plate dividing the medium cavity into a storage cavity and a jet flow cavity is integrated in the packaging shell, and the jet flow cavity communicates with a flexible connecting pipe section arranged over the heat exchange stand column in a suspended mode. Spiral fins are arranged on the surfaces of the heat exchange stand columns, horn-shaped flow guide pieces are arranged at orifices of the containing counter bores, and C-shaped groove flow guide fins which are arranged in a staggered mode are arranged on the bottom face of the heat conduction plate. According to the invention, low-thermal-resistance, high-flux and high-reliability direct contact type active heat dissipation for a high-power-density device is realized.
Owner:CHENGDU HANXIN GUOKE INTEGRATION TECH CO LTD

Method for detecting external vesicle marker through high-flux nano plasma exciting light immune color development

The invention provides a method for detecting an external vesicle marker through high-flux nano plasma exciting light immune color development, and belongs to the technical field of human extracellular vesicles. After a serum sample is subjected to centrifugal treatment, the serum sample and a CD81 capture antibody substrate are incubated, and the particle size distribution of the vesicles is monitored in real time; a zwitterionic polymer modified gold nanoparticle LAM detection probe and a polyethylene glycol modified silver nanoparticle LprG detection probe are prepared to be specifically combined with a vesicle surface antigen, a chromogenic enhancement solution is adopted to induce a plasma resonance signal, and full-hole scanning imaging is carried out; and constructing a double-layer game optimization model to cooperatively optimize the detection sensitivity and the signal stability, carrying out weighted summation on normalized signals of the particle size subgroups to obtain comprehensive detection signal intensity, comparing the comprehensive detection signal intensity with a threshold value, and outputting a final judgment result. The technical problem that quantitative accuracy is affected by signal intensity deviation caused by vesicle particle size difference in outer vesicle marker detection is solved.
Owner:QINGDAO RAISECARE BIOTECHNOLOGY CO LTD

Digital microfluidic system and method for multi-modal cell sorting analysis

The invention relates to the field of cell analysis, and provides a multi-mode digital micro-fluidic system and method for cell sorting analysis, the system comprises an active digital micro-fluidic platform, the active digital micro-fluidic platform comprises a micro-fluidic chip, an upper computer control system and an FPGA hardware circuit, an upper computer generates a liquid drop path planning instruction, the FPGA hardware circuit converts the liquid drop path planning instruction into an electrode driving signal, and the electrode driving signal is transmitted to the micro-fluidic chip; the nanoliter-grade liquid drops are driven to change between the electrodes; the optical tweezers platform comprises a laser device, an optical microscope and a CMOS camera, laser beams are generated by the laser device to form a three-dimensional optical potential well, the laser beams are transmitted into the micro-fluidic chip through the optical microscope to realize non-contact control on cells, and the CMOS camera records images and transmits the images back to the upper computer; the objective table clamp is used for realizing cooperative control of the optical tweezers and the active digital microfluidics; and the image recognition system is used for recognizing morphological characteristics of cells in the liquid drops based on a convolutional neural network and screening target cells. According to the invention, integration of high-throughput nondestructive cell sorting and in-situ multi-modal analysis is realized.
Owner:BEIJING INST OF TECH

High-flux electron beam quality cooperative control system and method

The invention discloses a high-flux electron beam quality cooperative control system and method, belongs to the technical field of electron beam control, and aims to solve the problems that the beam intensity and quality are difficult to consider, the subsystem collaboration is poor and the stability is insufficient. The cooperative control module is in communication connection with the sensing module and is used for receiving the state parameters, analyzing the state parameters based on a preset multi-target optimization algorithm and generating a cooperative control instruction, and the execution module is in communication connection with the cooperative control module and is used for receiving the cooperative control instruction and executing the cooperative control instruction according to the cooperative control instruction. Cooperative control of beam intensity and quality is realized. Through a multi-objective optimization algorithm, the limitation of traditional single parameter control is broken through, the beam intensity is larger than or equal to 100 mA, the emittance is smaller than or equal to 5 pi mm mrad and the energy dispersion is smaller than or equal to 0.5% can be achieved at the same time, and the technical problem that the beam intensity and the emittance are difficult to consider is solved.
Owner:SHANGHAI SINOTEX HIGH ENERGY TECH

Self-adaptive pipetting system and method based on multi-modal sensing fusion

The invention discloses a self-adaptive pipetting system and method based on multi-mode sensing fusion. The system comprises a PLC (Programmable Logic Controller), a fusion multi-mode sensing module, a high-throughput execution module, a self-adaptive protocol matching module and a man-machine interaction module. According to the invention, through multi-channel cooperation and continuous transmission, the experiment efficiency is greatly improved; multi-modal sensing data are fused, and real-time closed-loop control and dynamic compensation are performed by adopting algorithms such as fuzzy PID (Proportion Integration Differentiation) and the like, so that the pipetting volume precision reaches + / -1%, and the repeatability is improved by 20-30%; a protocol feature library and an intelligent matching algorithm are built in, and experimental parameters can be automatically analyzed, matched and optimized; equipment state and process parameters are monitored in real time, faults and pollution risks are automatically early warned, and the operation safety and reliability are remarkably improved in combination with automatic anti-pollution design; a PLC is deeply fused with a sensing module and a decision module, a sensing-decision-execution intelligent closed loop is constructed, and an accurate and reliable integrated solution is provided for automatic pipetting.
Owner:NINGBO XINGBOYUAN INTELLIGENT TECHNOLOGY CO LTD

Heat-conducting wave-absorbing composite material with three-dimensional interpenetrating network structure as well as preparation method and application of heat-conducting wave-absorbing composite material

The invention provides a heat-conducting wave-absorbing composite material with a three-dimensional interpenetrating network structure as well as a preparation method and application of the heat-conducting wave-absorbing composite material. The preparation method of the composite material comprises the following steps: impregnating carbon fibers in an ethanol dispersion liquid containing titanate, graphene quantum dots and polydopamine, carrying out low-temperature in-situ polymerization, and carrying out suction filtration and drying to obtain surface-functionalized carbon fibers; mixing the functionalized carbon fibers with an MXene / BNNS dispersion liquid, and performing freeze drying to obtain a functionalized carbon fiber three-dimensional honeycomb network skeleton; and impregnating the functionalized carbon fiber three-dimensional honeycomb network skeleton in a resin precursor solution containing a functional filler and a flame retardant to fill network gaps with resin, and heating and curing to obtain the composite material. The composite material completely meets the thermal management and electromagnetic compatibility requirements of 6G high-flux chip packaging; especially in a 6G AiP module, the material can effectively solve the problems of heat and electromagnetic interference generated by a high-power chip, and provides important support for commercial application of a 6G communication technology.
Owner:TAICANG JIN YU ELECTRONICS MATERIALS

Full-automatic high-flux space-time resolution fluorescence spectrum imaging system and method

ActiveCN121431371AFluorescence/phosphorescencePicosecond pulsed laserFluorescence spectra
The invention discloses a full-automatic high-flux space-time resolution fluorescence spectrum imaging system and method, and relates to the field of fluorescence signal spectrum. Comprising a working table, a sample table, an objective lens, a mechanical arm sample injection module used for grabbing the sample table loaded with a sample in advance and placing the sample table on the working table, and a picosecond pulse laser output module used for outputting a laser beam to the objective lens, the fluorescence signal detection module and the control module are used for simultaneously collecting spectral data and dynamic data of a fluorescence signal generated after the sample is focused by the laser beam; the sample table and the objective lens are sequentially arranged on the workbench at intervals in the vertical direction from top to bottom; the mechanical arm sampling module, the picosecond pulse laser output module and the fluorescence signal detection module are respectively in communication connection with the control module. According to the invention, simultaneous acquisition of spectrum data and dynamic data of fluorescence signals can be fully automatically realized.
Owner:UNIV OF SCI & TECH OF CHINA

High-flux cellulose immobilized tannin membrane adsorption material as well as preparation method and application thereof

The invention belongs to the technical field of radioactive wastewater treatment and uranium extraction from seawater, and discloses a high-flux cellulose immobilized tannin membrane adsorption material as well as a preparation method and application thereof. The membrane adsorption material comprises an aldehyde cellulose acetate microfiltration membrane and waxberry tannin which is cured on the microfiltration membrane through gradient cross-linking. The membrane adsorption material provided by the invention keeps a reticular porous structure of a cellulose microporous filter membrane and has the characteristics of high flux and rapid mass transfer, the pure water flux of a single-layer membrane can reach 300 L / (m.h), the treatment capacity of a multi-layer membrane is remarkably increased, large-flow treatment can be realized, and the efficiency of extracting uranium from seawater or uranium-containing wastewater is remarkably improved.
Owner:SICHUAN UNIV +1

Multifunctional pathological section scanning and arranging machine

A multifunctional pathological section scanning and arranging machine disclosed by the present invention comprises a rack, the rack is provided with a light path assembly, a scanning assembly, an XY platform, an objective table and a slide automatic loading assembly, the slide automatic loading assembly comprises a base, the base is rotatably connected with a rotating disc, the rotating disc is driven by a rotating disc motor fixedly installed on the base to rotate, and the rotating disc is driven by a motor to rotate. A plurality of partition columns are uniformly arranged on the turntable along the circumference at intervals, slide box placing positions are respectively arranged between every two adjacent partition columns and are used for placing slide boxes, a lifting station is arranged on one side, corresponding to the base, of the turntable, a lifting assembly and a guide assembly are respectively arranged on the base and correspond to the lifting station, and a slide pushing assembly is arranged at the upper part of the lifting assembly. The equipment disclosed by the invention integrates four basic functions of bright field, fluorescence, high flux and oil immersion lens, and has multiple purposes; and the automatic slide loading assembly can be used for sorting the scanned slides, so that an operator is helped to sort and sort the slides.
Owner:HANGZHOU DEEP INFORMATICS TECH CO LTD

Methods of preparing densified carbon nanotube (DCN) structures and the uses thereof

The present disclosure is directed polymer-free, non-composite densified carbon nanotube (DCN) structures from thin carbon nanotube (CNT) films and methods of making the same. CNT thin films can be cut, folded, stacked and pre-arranged in the form of cylinders, discs, domes, frames, gaskets, jars, rings, sacks, seals and sheets on a smooth reaction vessel surface and subsequently densified with the use of chlorosulfonic acid (HClSO3) at elevated temperatures. The disclosed DCN structures can be used as EMI shielding, lightweight structural and functional components in extreme conditions commonly encountered in space exploration, polar expeditions and military operations, and also as hydrophilic filtration media that resist surface fouling and provide high flux.
Owner:4TH PHASE TECH INC

High-flux high-pollution-resistance nanofiltration membrane as well as preparation method and application thereof

The invention discloses a high-flux high-pollution-resistance nanofiltration membrane as well as a preparation method and application thereof. The scheme is realized by constructing a gradient separation layer compounded by modified MOF and polyamide on a porous support layer; the preparation method comprises the following steps: preparing a water phase from modified MOF grafted with carboxylate radical and sulfonate ion recognition groups on the surface, a polyamine monomer and an ion channel regulator, carrying out interfacial polymerization on the water phase and an oil phase containing a fluorine-containing acyl chloride monomer on the surface of a porous support membrane, and carrying out heat treatment and metal ion post-treatment, the modified MOF in gradient distribution in the nanofiltration membrane can specifically adsorb Ca < 2 + >, Mg < 2 + > and other scaling ions, and scale formation is inhibited from the source; the composite structure simultaneously realizes high flux and high selectivity; the retention rate of the membrane to Na2SO4 under 0.6 MPa is greater than or equal to 99.2%, the retention rate of the membrane to NaCl is less than or equal to 15%, the flux of pure water is greater than or equal to 20 L.m <-2 >. H <-1 >. Bar <-1 >, and the flux attenuation rate is less than or equal to 16.7% after the membrane runs in high-hardness, high-COD and high-salinity wastewater for 120 hours; the scheme is particularly suitable for zero-discharge pretreatment of high-salinity wastewater such as solid waste percolate with the TDS of 5-30% and chemical engineering.
Owner:ZHEJIANG HUANKE ENG DESIGN CO LTD

Separation method of At-211 suitable for linear accelerator production

The invention relates to a separation method suitable for At-211 produced by a linear accelerator, which comprises the following steps: performing gradient pressing on bismuth powder and a pore forming agent, and sintering on a porous silicon carbide substrate to form a gradient pore bismuth-silicon carbide composite target material; bombarding the gradient pore bismuth-silicon carbide composite target material through a high-energy particle beam generated by a linear accelerator, and carrying out nuclear reaction on bismuth atoms in the target material to generate At-211; the bombarded target material is pretreated through argon plasma; distilling the pretreated target material under pulse carrier gas to realize volatilization separation of At-211, wherein the carrier gas comprises inert gas, reducing gas and organic acid steam; the distilled gas is subjected to gradient condensation through the micro-channel condenser; and adding an extracting agent into the micro-channel condenser, and dissolving the At-211 in the extracting agent to obtain an At-211 solution. The high-flux separation method of At-211 suitable for linear accelerator production, provided by the invention, is stable, efficient and rapid.
Owner:SHANGHAI ADVANCED RES INST CHINESE ACADEMY OF SCI

Preparation method of high-flux seawater desalination reverse osmosis membrane

The invention relates to the technical field of preparation of reverse osmosis membranes, and particularly discloses a preparation method of a high-flux seawater desalination reverse osmosis membrane, which comprises the following steps: step 1, preparing a water phase solution, mixing m-phenylenediamine and 4-aminoanisole according to a mass ratio of 4: 1, adding camphorsulfonic acid and triethylamine, then adding into deionized water, and stirring to obtain the water phase solution; the total mass fraction of m-phenylenediamine and 4-aminoanisole is 4 wt%, the mass fraction of camphorsulfonic acid is 4 wt%, the mass fraction of triethylamine is 2 wt%, and the total mass fraction of m-phenylenediamine and 4-aminoanisole is 4 wt%. The modified nano silicon dioxide is nano silicon dioxide modified by gamma-aminopropyltriethoxysilane, and the particle size of the modified nano silicon dioxide is 30nm. According to the preparation method of the high-flux seawater desalination reverse osmosis membrane, the purposes that the high flux, high stability, excellent corrosion resistance and high structural strength of the reverse osmosis membrane are synergistically improved, and the seawater desalination effect is remarkably optimized are achieved.
Owner:山东九章膜新材料有限公司 +1

Integrated liquid drop micro-fluidic chip based on 3D printing and liquid drop preparation method

The invention belongs to the technical field of microfluidics, and particularly relates to an integrated liquid drop micro-fluidic chip based on 3D printing and a liquid drop preparation method. Comprising a continuous phase channel unit and a dispersed phase channel unit, the continuous phase channel unit comprises a main channel unit, and a plurality of main split channels are communicated in the circumferential direction around an outlet of the main channel unit; the dispersed phase channel unit comprises a branch channel unit, a plurality of branch splitting channels are circumferentially communicated around an outlet of the branch channel unit, a droplet control structure is arranged at the communication part of the main splitting channel and the outlet of the branch splitting channel, and a droplet generation channel is arranged at the communication part of the outlet of the branch splitting channel and the outlet of the main splitting channel; an outlet of each liquid drop generation channel is communicated with a collection opening; the multiple collection openings communicate with the amplification section structure, and an outlet of the amplification section structure communicates with a total collection opening. The three-dimensional space is fully utilized, high-flux and uniform preparation of the liquid drops can be achieved, and the method is suitable for large-scale production of the liquid drops.
Owner:JIANGYIN MICROCHEMICAL PRECISION TECH CO LTD

Modified separation membrane as well as preparation method and application thereof

The invention provides a modified separation membrane as well as a preparation method and application thereof, the preparation method of the modified separation membrane comprises the following steps: obtaining a mixed system of a mineral aggregate and a polar solvent, performing ultrasonic liquid phase stripping on the mixed system to obtain a to-be-treated liquid, and the mass volume ratio of the mineral aggregate to the polar solvent is (50-100) mg: (30-60) ml; performing centrifugal treatment on the to-be-treated liquid, and collecting supernatant liquid to obtain nano suspension liquid; a cross-linking agent is mixed with the nano suspension to obtain modified liquid, the modified liquid contains the modified nanosheets, and the mass of the cross-linking agent is 2%-30% of the mass of the mineral aggregate; the modified liquid is filtered through a filter membrane, the modified nanosheets are evenly loaded on the surface of the filter membrane, and the modified separation membrane is prepared. The modified separation membrane prepared by the invention is a modified separation membrane material with high separation coefficient, high rejection rate and high flux, and has excellent performance.
Owner:CENT SOUTH UNIV

Imaging flow cytometry-based high-throughput drug screening method

An imaging flow cytometry-based high-throughput drug screening method, comprising: cell incubation, cell staining, acquiring single-cell images by using a flow cytometer, and image extraction and analysis, which combines the high-throughput advantages of flow cytometry and the imaging capability of a microscope, so that multi-channel single-cell images can be generated in a high throughput manner, thereby implementing acquisition of fluorescent images and unmarked images of single cells at a throughput of 102-105 cells per second, which can be used for cell phenotype drug screening and improving the screening efficiency by a factor of 102-104.
Owner:FAIRY LIFE SCIENCES (WUHAN) CO LTD

Raman activated cell sorting system coupled with microfluidic and Raman optical tweezers and method thereof

The invention relates to a Raman activated cell sorting system coupled with micro-fluidic and Raman optical tweezers and a method thereof, and relates to the technical field of cell sorting, the system comprises a micro-fluidic chip with low Raman and fluorescence background noise and a pneumatic micro-valve; in the micro-fluidic chip, a sample channel and a micro-cavity are connected with a main channel, and a flow guide channel is connected with the micro-cavity; the flow guide channel and the collecting channel are connected through a pneumatic micro valve. After the pneumatic micro valve is closed, the fluid in the micro cavity is static, and a narrow sample flow is formed in the main channel. And when the Raman collection time is less than the time difference of two adjacent cells flowing through the capturing point of the optical tweezers in the narrow sample flow, high-flux Raman detection can be performed in the narrow sample flow. On the contrary, the target cells can be moved out of the narrow sample flow, and high-precision Raman detection in a long Raman collection scene can be realized. After sorting is completed, fluid flowing of the main channel is stopped, the pneumatic micro valve is opened, the cells stored in the micro cavity are released and collected in a unified mode, the cell suspension volume is more stable and uniform, and follow-up experiment operation is facilitated.
Owner:QINGDAO SINGLE CELL BIOTECH CO LTD

Control method and control device for high-throughput biosynthesis ink-jet printing

The invention relates to the field of synthetic biology, in particular to a high-flux biosynthesis ink-jet printing control method and device, and the method comprises the steps: sequentially extracting base data from an obtained DNA base sequence file, and forming a one-dimensional original array; according to a preset printing width, the one-dimensional original array is converted into a two-dimensional array, meanwhile, visualization processing is carried out, corresponding colors are given to different basic groups, and a basic group distribution array diagram with matched row and column structures is obtained; establishing null arrays which correspond to different bases and are consistent in dimension based on the null arrays, traversing the original arrays and assigning values to the corresponding bases at the corresponding positions of the null arrays to obtain a plurality of single base arrays; converting the arrays into a two-dimensional array according to a preset width, and then converting the two-dimensional array into a monochromatic bitmap; and sending the bitmap according to the corresponding relationship between the basic groups and the nozzles and controlling printing. According to the invention, efficient and accurate printing of the base sequence in high-throughput biosynthesis is realized, and the synthesis efficiency and reliability are improved.
Owner:MICRO INK INTELLIGENT TECH (NANTONG) CO LTD

Iron-based high-temperature alloy design method based on multi-model machine learning and alloy thereof

The invention relates to an iron-based high-temperature alloy design method based on multi-model machine learning and an alloy thereof, and the method comprises the following steps: 1, obtaining iron-based high-temperature alloy components, carrying out high-throughput calculation, and constructing a data set; 2, correlation analysis is carried out on the data set, feature importance sorting is carried out based on a random forest model, and key components are screened out; 3, constructing a machine learning algorithm model, training by using the key components, and adjusting and optimizing hyper-parameters of the machine learning algorithm model through an optimization algorithm to obtain a trained prediction model; 4, constraint conditions are constructed and optimized, an optimal solution set is obtained, the optimal solution set is input into the trained prediction model, and optimal alloy components are obtained; and 5, laser powder bed melting forming is conducted according to the optimal alloy components, and the iron-based high-temperature alloy is obtained. A data-driven machine learning method is adopted to replace a traditional trial and error method, the alloy research and development period is greatly shortened, and the research and development cost is reduced.
Owner:SHANDONG UNIV

Asymmetric sulfone polymer nanoscale filter membrane as well as preparation method and application thereof

The invention discloses an asymmetric sulfone polymer nanoscale filter membrane as well as a preparation method and application thereof, and belongs to the technical field of membrane materials. The filter membrane comprises a filter membrane main body, the filter membrane main body comprises a pre-filtering layer and a separation layer for intercepting impurities, the average thickness of the separation layer is 0.5-12 microns, and the porosity is 40-80%; the ratio of the maximum aperture of the PMI to the minimum aperture of the PMI of the filter membrane is 1.2-3.5, the retention rate of the filter membrane to 2nm colloidal gold is greater than or equal to 90%, and the ratio of the standard deviation of the area value of the brightness displacement spectrum to the average value of the area value is 0.01-2 when the filter membrane with the retention rate of 2nm colloidal gold is subjected to section brightness measurement; the separation layer structure which is thin and uniform in thickness and the proper pore size and pore size distribution of the filter membrane are combined with high porosity, so that the filter membrane can be ensured to have high flux and high cleanliness while having high interception efficiency, and the filter membrane is suitable for nanoscale purification of a liquid treatment agent used in a semiconductor wet process.
Owner:HANGZHOU COBETTER SEMICONDUCTOR SEPARATION MEMBRANE CO LTD

High-flux non-contact ultrasonic crusher driven by fluid to rotate

The utility model provides a high-flux non-contact ultrasonic crusher driven by fluid to rotate, which is provided with an annular groove, and liquid discharged from the interior of the annular groove relatively acts with a bracket baffle at the bottom of a disc-shaped bracket, so that the disc-shaped bracket is driven by the fluid to rotate relative to the annular groove, and ultrasonic treatment is carried out in the annular groove. According to the invention, batch samples are rotated in the annular ultrasonic field, so that the batch samples can be ultrasonically crushed under the same condition, the treatment condition is homogenized, the sample treatment capacity requirement is met, the consistency of sample crushing results is improved, and the treatment efficiency is greatly improved.
Owner:ZHUHAI AIBOLUO BIOLOGICAL TECH CO LTD

Multiplex high-throughput analysis system and method based on microfluidics, and microfluidic chip

The invention relates to a three-dimensional multiple high-throughput analysis system and method based on microfluidics, and the system comprises a microfluidic chip integrating a temperature control reaction area and a detection area, an X-ray plate scanning module, a lens-free imaging unit, a synchronous control system and a data processing module. The device breaks through the bottleneck of plane limitation and spectrum crosstalk in the traditional technology, realizes high flux, three-dimensional space resolution and multi-parameter comprehensive analysis (multi-channel fluorescence + three-dimensional form + reaction kinetics), and has the characteristics of compact equipment, low cost, easiness in maintenance and the like; and an efficient and flexible analysis tool is provided for the fields of biomedical research, clinical diagnosis, drug screening and the like.
Owner:SHANGHAI TORRES DIAGNOSTIC TECHNOLOGY CO LTD

Reversible cross-flow filtering membrane device

The utility model belongs to the field of water treatment and material separation, and provides a reversible cross-flow filtering membrane device, which comprises a membrane unit, a water outlet end interface, two circulation end interfaces, a first pipeline, a second pipeline, a second pipeline and a third pipeline, the membrane unit is provided with a water production end interface and two circulation end interfaces, the two circulation end interfaces are communicated through the first pipeline, the first pipeline is provided with a two-way liquid pumping assembly, and the flow direction of fluid can be changed through the two-way liquid pumping assembly; an outlet of the water inlet pump communicates with the first pipeline, and a check valve is arranged at the outlet of the water inlet pump; and the water producing tank is communicated with the water producing end interface through a second pipeline. According to the device, the two circulation end interfaces of the membrane unit are communicated through the first pipeline to form a circulation loop, and then the reversing of circulating water flow can be realized through the two-way liquid pumping assembly. By arranging a pressure sensor, a control system and the like, the circulation direction can be automatically switched according to pressure or timing, and bidirectional cross-flow filtration of the membrane unit is realized. The accumulation of pollutants on the surface of the membrane can be avoided, the risk of membrane pollution blockage and scaling is reduced, high flux can be maintained, the membrane washing frequency is reduced, and the operation cost is reduced.
Owner:HUEYA ENVIRONMENTAL ENG