140 results about "Ion channel" patented technology

The invention discloses a screen cloth enhanced polybenzimidazole porous membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: fully mixing polybenzimidazole, a polar solvent and a template to obtain a mixed solution, coating a base material with the mixed solution, placing a polymer mesh on the previous base material, and carrying out in-situ compounding, polar solvent removal and film formation to obtain a compact mesh reinforced polybenzimidazole film; and then carrying out in-situ etching treatment to prepare the screen cloth enhanced polybenzimidazole porous membrane. The size and connectivity of ion channels in the membrane can be regulated and controlled by regulating and controlling the type and content of templates in the membrane casting process, and the polybenzimidazole porous layer can be ultrathin by combining the effect of enhancing the mechanical property of the polymer mesh cloth, so that the mass transfer resistance of the polybenzimidazole porous separation layer is remarkably reduced, and the performance of the membrane is improved. The mesh-reinforced polybenzimidazole porous membrane has good dimensional stability and pore uniformity, and has the characteristics of high ion selectivity, high ion conductivity and high stability.

The invention relates to the technical field of all-vanadium redox flow batteries, in particular to a high-oxidation-resistance polybenzimidazole proton exchange membrane as well as a preparation method and application thereof. According to the proton exchange membrane, different polymeric monomers with high oxidation resistance are mixed in the reaction process to prepare a polybenzimidazole block copolymer, and after the membrane formed by the polybenzimidazole block copolymer is soaked in high-concentration acid liquor, rapid and selective conduction of protons is achieved. Aiming at the problems that in the application process of poly (2, 2 '-(p-oxybiphenyl)-5, 5'-benzimidazole) in an all-vanadium redox flow battery, a polymer skeleton is easily oxidized by VO < 2 + > ions, so that the battery capacity is attenuated, and the energy conversion efficiency is continuously reduced, the preparation method comprises the following steps: synthesizing a high-oxidation-resistance polybenzimidazole block copolymer main chain; the microphase separation structure of the polybenzimidazole block copolymer membrane can be effectively improved, a rapid ion channel is constructed in the polybenzimidazole block copolymer membrane, and meanwhile, the utilization rate of an acid solution is increased.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

The invention discloses an ordered ion channel polyamide nano composite membrane, a preparation method and application, relates to the field of lithium magnesium membrane separation, and aims to solve the problem of poor selectivity in the prior art. The technical scheme is as follows: amino benzo crown ether is covalently grafted on an ultrafiltration base membrane in situ through diazotization-coupling reaction; then, a polyamide compact layer is prepared on the crown ether nano layer subjected to in-situ self-assembly through interfacial polymerization, and the polyamide nano composite membrane with the ordered ion transmission channel is jointly constructed. The residual amino groups on the surface of the in-situ covalent grafted crown ether nano layer can also participate in interfacial polymerization reaction, so that the ordered ion channel crown ether macromolecular layer and the polyamide compact layer are connected through chemical bonds to jointly form the polyamide nano composite membrane with the ordered ion transmission channel. And the method is suitable for extracting lithium from the salt lake brine.

The invention discloses a method for quantifying response of two carbon utilization modes of microalgae to weathered carbon sink of magnesium-containing silicate rock, which comprises the following steps: culturing two groups of microalgae under the same culture condition, adding magnesium-containing silicate rock and microalgae into one group, and setting an inhibitor (AZ / DIDS) added with a certain carbon utilization mode as an experimental group; and only magnesium-containing silicate rock and microalgae are added into one group as a blank group without adding an inhibitor (AZ / DIDS) of a certain carbon utilization mode. Setting the treatment group added with AZ (10mM) and DIDS (2mM) as an experimental group, and subtracting the weathering quantity of the magnesium-containing silicate rocks in the treatment group not added with AZ / DIDS and the treatment group added with AZ / DIDS to obtain the weathering quantity delta Ti of the magnesium-containing silicate rocks under the influence of the microalgae anion channel utilization mode, namely delta Ti = Ti-Ti (AZ / DIDS), and rock weathering carbon sink Qi = delta Ti under the influence of the microalgae anion channel utilization mode. Fitting a polynomial function Q = Q (i) to obtain the response function of the microalgae extracellular carbonic anhydrase mode or the microalgae anion channel utilization mode to the weathering carbon sink of the magnesium-containing silicate rock. According to the method, the rock weathering carbon sink quantity under the influence of two carbon utilization modes of the microalgae can be rapidly and accurately obtained. The invention provides the method for quantifying the response of the two carbon utilization modes of the microalgae to the weathered carbon sink of the magnesium-containing silicate rock so as to overcome the defect that the response of the two carbon utilization modes of the microalgae to the weathered carbon sink of the magnesium-containing silicate rock cannot be quantified in the prior art.

Systems and techniques are provided for making genetically engineered ion channels (ICs) with bioluminescent resonance energy transfer (BRET) complexes and using such ICs for efficient readout of neural activity and output of biological neuronal networks.SOLUTION: In one implementation, the disclosed technology includes identifying a target location in the IC for expression of a target protein including a donor tag protein and an acceptor tag protein, and modifying the genome of the neuronal cell at a portion associated with the target location in the IC. The technique further includes causing the neuronal cell to express the target protein in the IC according to the modified genome. In the first (second) state of the IC, the donor tag protein is at a first (second) distance from the acceptor tag protein that is related to the absence (presence) of energy transfer between the donor tag protein and the acceptor tag protein.SELECTED DRAWING: Figure 3A-3C

The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.

This application discloses a self-cleaning electrolysis module and electrolysis equipment. The self-cleaning electrolysis module includes a shell and an electrolysis space within the shell. The electrolysis space is divided into a first chamber with a first electrode and a second chamber with a second electrode by a first separator. The first and second electrodes have opposite polarities and their polarities can be switched. The first separator is an ion channel for cations. The first chamber is provided with a first inlet pipe and a first outlet pipe, and the second chamber is provided with a second inlet pipe and a second outlet pipe. The first and second inlet pipes are arranged in parallel. When the electrode in any chamber is an anode, the inlet and outlet pipes of the current chamber are connected, and the inlet pipes of adjacent chambers are disconnected. The self-cleaning electrolysis module of this application can output electrolysis products with high redox potentials and can also achieve self-cleaning of scale in the chamber by switching electrode polarities.

Provided herein are depolarizing ion channel therapeutics and methods of using the same for treating retinal and neurodegenerative diseases.

The invention belongs to the technical field of plant genetic engineering, and particularly discloses a nitrate ion transport channel gene PbrSLAH3b and application of the nitrate ion transport channel gene PbrSLAH3b in promoting growth of pear pollen tubules. The method comprises the following steps: extracting total RNA (Ribonucleic Acid) of Dangshan pears from pollen of Dangshan pears; carrying out reverse transcription on the RNA to obtain cDNA (complementary deoxyribonucleic acid); and by taking the cDNA as a template, carrying out amplification to obtain the pear pollen tube nitrate transport channel gene PbrSLAH3b, the PbrSLAH3b gene provided by the invention belongs to a slow anion channel SLAC / SLAH family member, the PbrSLAH3b is remarkably up-regulated in expression in the early growth stage of a pollen tube, and the PbrSLAH3b is positioned in a plasma membrane. The invention verifies that PbrSLAH3b can form a functional anion channel with NO3 <-> selectivity under the condition of not depending on proton gradient or phosphorylation state, and the PbrSLAH3b has relatively strong selectivity on NO3 <->. Therefore, the PbrSLAH3b gene can mediate the absorption and transport of the pollen tube to NO3 <-> and maintain the polarity growth directivity of the pollen tube, and has important application value for revealing the ion regulation mechanism of the growth of the fruit tree pollen tube and improving the reproductive development of the fruit tree.

The application discloses an ion channel based on a poly-polypeptide skeleton and application thereof, and rational use of the poly-polypeptide main chain length difference of different polymerization degrees and the structure-activity relationship difference of different secondary structures of the poly-polypeptide is used in the poly-polypeptide ion channel of the application, the polymerization degree and the secondary structure of the poly-polypeptide are regulated, the length of the poly-polypeptide and the arrangement of the side chain functional groups are regulated, and then the opening or closing of the poly-polypeptide ion channel is regulated, a responsive poly-polypeptide ion channel is designed by introducing a suitable responsive group into the side chain of the poly-polypeptide, and therefore the tumor-specific activation of the poly-polypeptide ion channel is realized, and inspiration is provided for the design and application of the artificial ion channel.

The invention provides an energy-gathering electrode device for breaking large rocks through electric pulses and a using method, and relates to the technical field of breaking of large rocks. The device comprises. The device comprises a positive electrode connecting port, a negative electrode connecting port, a liquid injection port, a rubber sleeve, a plugging piece, an insulating piece, a negative electrode ring and a positive electrode cross electrode structure. A V-shaped energy-gathering groove is formed in the periphery of the insulating part; and the tip of the positive cross electrode structure extends to the edge of the energy-gathering groove. During use, water is injected into the rubber sleeve, then the rubber sleeve is placed in a rock drill hole, the distance between the negative electrode ring and the positive electrode cross electrode is adjusted, so that a directional plasma channel is formed in the energy gathering groove through discharge, generated shock waves are transmitted to rock through a water medium, and energy gathering and releasing are achieved. The invention solves the problems of energy dispersion and low efficiency in traditional electric pulse crushing, is particularly suitable for directional and efficient crushing of large rocks, and has the advantages of simplicity and convenience in operation, high energy utilization rate and environmental protection.

The invention relates to a compound which is effective in inhibiting the function of the TRPM4 ion channel and the use of such compound in treating or preventing a TRPM4-associated disorder in a subject such as neurodegenerative diseases like stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and neurodegenerative disease under inflammatory conditions, in particular multiple sclerosis, or genodermatosis, cardiac diseases, and immunemediated diseases. The invention also provides a pharmaceutical composition comprising the TRPM4 inhibitory compound.

Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect intracellular ion channel function, and are useful as or in conjunction with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and disorders, including inflammatory eye diseases (e.g., uveitis), cardiovascular diseases, inflammatory diseases, and diseases characterized by aberrant hyperplasia (e.g., cancer).

The application belongs to the technical field of fuel cell application, and discloses a polynorbornene-based anion exchange ionomer with double-domain coupled ion channels, a preparation method and application thereof. The polynorbornene-based anion exchange ionomer simultaneously constructs an ion domain rich in cation groups and a synergistic functional domain rich in oxygen-containing functional groups at a molecular scale, the two types of domains are coupled with each other in the material and form a continuous double-domain ion transmission network, so that the ionomer can still maintain a stable and continuous hydrogen and oxygen ion transmission channel under the conditions of a thin layer state of a cathode catalyst layer and limited hydration, and effectively improves the ion transmission connectivity and catalyst utilization efficiency of the catalyst layer interface. The ionomer is suitable for being used as an ion-conducting bonding material of a cathode of an alkaline membrane fuel cell, can improve the oxygen reduction reaction performance of the cathode, and provides a new material and structural design idea for a low-noble metal loading and high-power density fuel cell electrode structure design.

The invention discloses a high-conductivity alkaline anion exchange membrane and a preparation method thereof, the high-conductivity alkaline anion exchange membrane is prepared from a rigid aromatic monomer, reactive quaternized polyarylether sulfone, immobilized quaternary ammonium salt, hydrophobic mesoporous SiO2 and a cross-linking agent, and the surface of the high-conductivity alkaline anion exchange membrane is provided with a cation density gradient transition layer and an anti-corrosion coating. The alkali-resistant stability of the membrane is improved through covalent bonding of quaternary ammonium and a three-dimensional cross-linked structure, the mesoporous SiO2 regulates swelling and constructs an ion channel, and the interface contact resistance is reduced through a gradient structure. And the OH <-> conductivity at 80 DEG C reaches 149-168 mS / cm, the 4000 h alkali-resistant retention rate is greater than or equal to 90%, the in-plane swelling rate is less than or equal to 5.1%, the interface contact resistance is as low as 0.08 omega.cm < 2 >, and the composite material has the advantages of high conductivity, low swelling, high alkali resistance and excellent interface compatibility, and is suitable for alkaline fuel cells.

This invention provides a method for improving the antidepressant effect of an NMDAR pore channel blocker, comprising: (1) performing behavioral, pharmacological, or physical measures before or during the plasma half-life of the NMDAR pore channel blocker to open ion channels of a larger proportion of NMDAR molecules in the lateral habenula (LHb); and optionally (2) performing behavioral, pharmacological, or physical measures after administration of the NMDAR pore channel blocker to prevent or reduce the dissociation of NMDAR pore channel blocker molecules from NMDAR. Treatment regimens and drug combinations for effectively treating depression are also provided. This disclosure further provides a drug delivery system comprising an implantable unit capable of controlled, repeatable, and precise in vivo delivery of an NMDAR pore channel blocker, as well as an initiator and / or enhancer, to an LHb region of a subject's brain, thereby achieving improved therapeutic effects.

The application provides application of an adenosine A2B receptor as a target in a medicine for preventing and / or treating itch, and belongs to the technical field of biological medicines. Based on previously reported single-cell RNA sequencing data of a mouse dorsal root ganglion (DRG), expression of genes encoding main ligand ion channels is detected, Adora2b highly expressed in Neuron_10 is detected, and it is indicated that Adora2b and a receptor (adenosine A2B receptor) of Adora2b can participate in regulating itch. Experiments prove that the activity of the adenosine A2B receptor can be effectively blocked to prevent a histamine-induced scratching behavior of a mouse, and it is indicated that the A2B receptor participates in histamine-induced itch sensation. The application also provides application of a reagent for inhibiting biological functions of the adenosine A2B receptor in preparation of a medicine for preventing and / or treating itch, and provides a new means for prevention and treatment of itch.

The invention discloses application of a nano-channel membrane to chiral amino acid recognition in a nano-fluid device, and belongs to the technical field of nano ion channels.The nano-fluid device comprises two conductance cells and a beta-CD-SHGO / SCNF nano-channel membrane arranged between the two conductance cells, electrodes are placed in the two conductance cells respectively, and the two conductance cells are filled with a salt solution; according to the application, the amino acid enantiomers are added into the two conductance cells of the nanofluid device, and chiral recognition detection data of the amino acid enantiomers are obtained. The nano-channel membrane has abundant ion transmission paths, good mechanical properties and abundant chiral surface groups, and has excellent selective adsorption recognition performance, high recognition sensitivity, wide concentration range of applicable recognition of chiral amino acids and considerable application value when being applied to recognition of chiral amino acids.

The invention discloses a method for preparing a stable metal zinc negative electrode surface of a beta-cyclodextrin modified polyion elastomer copolymer electrolyte membrane, which comprises the following steps of: preparing mixed slurry of a polyion elastomer and beta-cyclodextrin by taking metal zinc as a substrate through chemical polymerization and microphase separation strategies; a metal zinc substrate is uniformly coated with the obtained slurry, a copolymer electrolyte membrane is constructed on the surface of metal zinc, the obtained copolymer electrolyte membrane has the functions of corrosion protection, regulation and control of zinc ion transportation and inhibition of hydrogen evolution reaction, beta-cyclodextrin in the copolymer electrolyte membrane can provide an ion channel for zinc ions, a diffusion path can be standardized, and the service life of the electrolyte membrane is prolonged. And the mass transfer process is accelerated, and zinc ions are induced to horizontally deposit along the (002) crystal face. The beta-cyclodextrin modified polyion elastomer stabilized metal zinc negative electrode surface multifunctional copolymer electrolyte membrane disclosed by the invention has the physical properties of high breaking strength, high flexibility and good conductivity, and has a self-repairing function; and the internal ion grid structure can obviously prolong the cycle life of the zinc metal battery in an aqueous electrolyte.

This application relates to the field of electrochromic materials technology, and discloses a polymeric electrochromic material and its application in anti-glare rearview mirrors. The polymeric electrochromic material is formed by in-situ polymerization and curing under ultraviolet light of a solvent, a polyurethane prepolymer with terminal double bonds, a violet derivative containing double bonds, a complementary electrochromic material, and a photoinitiator. The violet derivative containing double bonds is covalently anchored to the three-dimensional polymeric gel network framework formed by the crosslinking of the polyurethane prepolymer with terminal double bonds. This invention restricts the directional migration of the chromogenic groups through chemical bonding, effectively solving the problems of easy leakage and delamination during long-term operation of traditional devices. Simultaneously, the use of polyether soft segments to construct ion channels ensures that the device has a second-level response speed and high optical contrast. The material has a simple preparation process, good weather resistance, and is particularly suitable for automotive anti-glare rearview mirrors.

TRPV1 is an integral cation channel widely expressed in various tissues and involved in critical biological functions, such as thermosensation. It is polymodally activated by distinct stimuli, including chemical ligands, heat, and protons (pH). However, dozens of clinical trials targeting various types of TRPV1 -mediated pain have generally failed, primarily due to hyperthermia (increased body temperature). Meta-analysis of clinical data suggests that mode-selectivity is essential to realizing the therapeutic potential of TRPV1. TRPV1 is regulated allosterically, with vanilloids and other chemical ligands binding to the voltage-sensing-like domain (VSLD), resulting in the gating of the pore domain. Therefore, compositions and methods for modulating TRPV1 to treat human pathophysiologies, such as pain, are described herein.

The invention discloses a cardiac ion channel disease detection primer group and application thereof. The microfluidic chip and the multi-gene risk assessment model are combined, so that the risk of the cardiac ion channel disease can be assessed for potential patient groups, risk early warning is provided for the potential risk groups, the risk groups are guided to perform medical diagnosis and treatment, the risk of diseases or sudden death caused by the ion channel disease is reduced, and the application prospect is wide.

A drug development support device is provided with a processor. The processor acquires a first variation waveform, which is a variation waveform of an external potential of an iPS myocardial cell, which is a myocardial cell derived from a human iPS cell, and which is measured in a case where a candidate substance for a pharmaceutical product is added to the iPS myocardial cell while changing the addition amount of the first variation waveform, the first variation waveform being measured in accordance with the variation waveform of an external potential of the iPS myocardial cell, the iPS myocardial cell being the myocardial cell derived from the human iPS cell. Outputting, from the prediction model, a first prediction value for each addition amount for each ion channel obtained by a first prediction value indicating the degree of inhibition of the flow of ions present in a plurality of ion channels in the iPS myocardial cells by the degree of inhibition of the candidate substance; deriving, for each ion channel, an index value indicating a dose-reaction relationship of the candidate substance on the basis of the first predicted value for each addition amount; and presenting the estimated reference information corresponding to the index value and the estimated reference information referenced in order to estimate the mechanism of action based on the candidate substance to the user.

The invention discloses a method for removing heavy metal chromium ions in wastewater, and belongs to the technical field of industrial wastewater treatment and heavy metal pollution treatment. The method comprises the following steps: constructing a packed bed electrodialysis system in which a light chamber is filled with an ion exchanger, sequentially introducing chromium-containing wastewater to be treated into the light chamber, respectively introducing a sodium sulfate aqueous solution into a concentrated chamber and a pole chamber, applying direct current, and adopting frequent pole reversal operation. According to the method, deep removal is achieved through selective adsorption of the ion exchanger on chromium ions, efficient separation and concentration of the chromium ions are achieved through an ion channel constructed by the direct-current electric field, the ion exchange membrane and the ion exchanger, and meanwhile in-situ regeneration and reuse of the ion exchanger are achieved by periodically switching the direction of the electric field. The continuous advanced treatment of the chromium-containing wastewater can be realized, the hexavalent chromium concentration of the effluent is stably lower than 0.5 mg / L, the chromium recovery rate exceeds 90%, secondary hazardous waste pollution is avoided, the operation energy consumption is low, the cost is low, and large-scale industrial application is easy.

A compound suitable for treating, ameliorating and / or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade is provided. The compound can inhibit the CIC-1 ion channel.

The invention discloses a large-area electrode device structure and a solution resistance reduction and gas separation method. The device structure comprises an electrode and an electrolyte, the electrode is immersed in the electrolyte, a plurality of micro through holes penetrating along a specified direction are distributed in the electrode, part of the electrolyte is filled in the micro through holes to form an ion channel, and the first electrode and the second electrode at least pass through the ion channel to realize electrochemical conduction. According to the invention, the micropores are filled with the electrolyte to form an ion channel similar to a salt bridge, and the channel provides a shorter transmission path for ions, that is, transmission is carried out with smaller resistance, so that the voltage loss caused by huge resistance due to a long transmission distance is solved; the micropores filled with the electrolyte have the functions of blocking gas permeation, namely separating gas generated by reaction, so that the device can generate a target product in a more efficient manner, the effective working area of the electrode is not influenced, the performance of the device is not influenced, and the efficiency of the device is maximized.

The invention relates to a piezoelectric nano-material with ultrasonic responsiveness, which is a PVP (Polyvinyl Pyrrolidone) modified bismuth oxyiodate nano-sheet, the particle size is 100-200 nm, and a surface electric field can be generated under the ultrasonic action. The piezoelectric nano material can hyperpolarize the potential of a T cell membrane and inhibit an ion channel Kv1.3 regulated and controlled by the membrane potential, so that Th17 cell differentiation is reduced, and joint inflammation is relieved; the piezoelectric nano material is further prepared into a joint injection preparation, and the joint injection preparation can be combined with ultrasonic irradiation to be applied to treatment of rheumatoid arthritis. According to the invention, the piezoelectric nano material is successfully applied to immune microenvironment regulation and control of rheumatoid arthritis for the first time, and the product and technology blank in the field of'precisely regulating and controlling immune cell functions by using physical signals to treat autoimmune diseases' is filled.

The invention belongs to the technical field of energy materials, and particularly relates to a reversible thermal shutdown diaphragm and application. According to the invention, the reversible thermal shutdown diaphragm structure is designed by utilizing the temperature dependence of the rheological behavior of a polymer melt; the reversible thermal shut-off diaphragm is of a three-layer composite structure formed by sequentially stacking a moist-resistant layer, a middle shut-off layer and a moist-friendly layer. The reversible thermal shut-off diaphragm can realize a reversible thermal response function near a polymer melting point of a middle shut-off layer, that is, an ion channel is reversibly closed and recovered in a specific temperature interval, so that thermal runaway is effectively prevented, and the reversible thermal shut-off diaphragm has excellent reversible recovery characteristic. The reversible thermal turn-off diaphragm realizes reversible opening and closing of a pore structure in a specific temperature window by accurately controlling the spatial distribution behavior of a polymer melt in a solid-liquid phase change interval, has rapid reversible thermal turn-off capability, and is suitable for a safety protection system of a high-specific-energy power battery.

The utility model discloses a mass analyzer and ion implantation equipment, and the mass analyzer comprises a cavity which is internally provided with an ion channel for the circulation of an ion beam current; the beam current detection device is movably installed in the ion channel, the beam current detection device comprises a beam current receiving assembly used for receiving the ion beam current, and when the beam current detection device is in a detection state, the beam current receiving assembly blocks the ion channel, so that the first surface of the beam current receiving assembly receives the ion beam current; the purpose of detecting the beam current in the middle section of the beam current is achieved, when the ion beam current detection result does not meet the preset requirement and the beam current needs to be adjusted, due to the fact that the number of parts needing to be adjusted in front of the mass analyzer is small, the difficulty of adjusting the ion beam current is reduced, and the efficiency of adjusting the ion beam current is also improved.