210 results about "Ion channel" patented technology

The invention relates to the technical field of transmission membranes, in particular to a transmission membrane based on dithienylethene and a preparation method of the transmission membrane. The transmission film comprises a base film and light-operated molecules, the base film is coated with the light-operated molecules, and the light-operated molecules have light response groups. A detection result shows that after ultraviolet irradiation, the transmission film can quickly realize complete conversion from an open loop to a closed loop; after visible light irradiation is recovered, the transmission film can efficiently and reversibly recover to an open-loop state. In addition, the transport membrane has a high on-off ratio to five ions of sodium, potassium, lithium, magnesium and calcium. The transmission membrane based on dithienylethene, which is prepared by taking terminal amino-modified dithienylethene as a basic unit, not only has abundant nano-channels, but also is endowed with the characteristic of regulating and controlling the opening and closing of the nano-pore by a photoresponse functional group, and the closing and opening of an ion channel can be accurately regulated and controlled through the alternate irradiation of ultraviolet light and visible light, so that the transmission membrane has a good application prospect. And the controllability of light-operated ion transmission is finally realized.

The invention discloses a screen cloth enhanced polybenzimidazole porous membrane as well as a preparation method and application thereof. The preparation method comprises the following steps: fully mixing polybenzimidazole, a polar solvent and a template to obtain a mixed solution, coating a base material with the mixed solution, placing a polymer mesh on the previous base material, and carrying out in-situ compounding, polar solvent removal and film formation to obtain a compact mesh reinforced polybenzimidazole film; and then carrying out in-situ etching treatment to prepare the screen cloth enhanced polybenzimidazole porous membrane. The size and connectivity of ion channels in the membrane can be regulated and controlled by regulating and controlling the type and content of templates in the membrane casting process, and the polybenzimidazole porous layer can be ultrathin by combining the effect of enhancing the mechanical property of the polymer mesh cloth, so that the mass transfer resistance of the polybenzimidazole porous separation layer is remarkably reduced, and the performance of the membrane is improved. The mesh-reinforced polybenzimidazole porous membrane has good dimensional stability and pore uniformity, and has the characteristics of high ion selectivity, high ion conductivity and high stability.

The invention relates to the technical field of anion exchange membranes, in particular to a dual-ion-channel synergistic enhanced conduction anion exchange membrane for alkaline water electrolysis hydrogen production and a preparation method of the dual-ion-channel synergistic enhanced conduction anion exchange membrane for alkaline water electrolysis hydrogen production, and the dual-ion-channel synergistic enhanced conduction anion exchange membrane for alkaline water electrolysis hydrogen production is prepared by blending and crosslinking quaternized polyether-ether-ketone and carboxylated polyether sulfone, the carboxylated polyethersulfone provides a cation channel to form a double-ion synergistic conduction structure; the preparation process of the anion exchange membrane comprises the steps of quaternized polyether-ether-ketone synthesis, carboxylated polyether sulfone synthesis, membrane casting solution preparation, tape casting drying, crosslinking treatment and alkali liquor ion exchange. By constructing a double-ion channel structure, the synergistic conduction of anions and cations is realized, and the total ion conduction efficiency of the membrane is remarkably improved. The two polymer components form a continuously interlaced channel network, so that the defect that the conduction path of the traditional single ion channel membrane is isolated is avoided.

The invention discloses a normal-temperature and normal-pressure optical fiber chemical synthesis method and device. The core is a sandwich type optical fiber chemical membrane electrode (anode / ion exchange membrane / cathode + diffusion layer); the parallel scattering type optical fiber realizes near-uniform illumination and local enhancement on an interface. The anode uses 90-112 nm VUV to promote H dissociation, and the cathode uses 80-100 nm VUV to activate and reduce N; the direct current / pulse of the power supply is programmable. The membrane is PEM / AEM / CEM (5-200m), and an ion channel is functionally optimized through nanofiller, crosslinking and functionalization; and the catalytic surface is loaded with 1-100nm of transition metal compound and anchored. Arranging an inert / reduced-pressure sealed light path to improve VUV coupling; raw material gas H: N = 1: 1-5 (preferably 1: 3), and inert carrier gas can be added. The system is connected to online characterization and AI closed loop, ammonia is continuously produced at 0-40 DEG C and 0.8-1.2 atm, and selectivity and Faraday efficiency are improved.

The invention relates to a composite solid electrolyte and a preparation method thereof, the composite solid electrolyte comprises: a lithium zirconium phosphate (LZP) oligomer: a chain nanocluster with a polymerization degree of 5-10, the surface of which is modified by trimethyl phosphate (TMP) to form a phosphate group; a polymer matrix, namely PVDF-HFP; the lithium salt is lithium bis (trifluoromethanesulfonimide) LiFSI or LiDFOB, and the molar ratio of the lithium salt to the polymer repeating unit is (1: 8)-(1: 12); wherein the LZP oligomer and a-CF2 group of the PVDF-HFP form a hydrogen bond through a phosphate group of the TMP, and the LZP oligomer and the-CF2 group of the PVDF-HFP interact with each other through a dipole, so that molecular-level interface bonding is realized; the LZP oligomer constructs a continuous three-dimensional ion channel in the electrolyte, and the dielectric constant is 60-80; the electrolyte forms a film at 60 DEG C or below by a solution casting method.

A construction and use of an environmentally adaptive co-regulated mRNA nanodelivery system. By incorporating EACR molecules into mRNA nanoparticles, the microenvironment is remodeled to be suitable for robust and sustained mRNA expression, while tissue damage associated with the self-immunogenicity of mRNA drugs is avoided. The nanodelivery system is compatible with ionizable lipid nanoparticles, cationic liposomes, cationic nanoemulsions, and polymeric nanoparticles. The EACR molecules include: anti-inflammatory drugs, tyrosine kinases / adaptors, JAK / STAT and MAPK pathway inhibitors, nutrients and metabolites, membrane transporters / ion channels, phosphodiesterase and cellular stress inhibitors, and natural viral proteins. The therapeutic mRNAs may encode tumor, viral, or bacterial antigens, immunomodulatory factors, therapeutic antibodies, or functional proteins / enzymes, and can play a role in the fields of regenerative medicine, protein supplementation / replacement therapy, targeted gene editing, and immunotherapy.

The invention discloses a water-absorbing and moisture-preserving type long-acting resistance-reducing grounding module and an industrial production method thereof. The water-absorbing and moisture-preserving type long-acting resistance-reducing grounding module comprises a grounding module body, a graphite-based flexible grounding belt and a water-absorbing pipe. The grounding module body is obtained by mixing graphite chippings, bentonite and water glass and then performing compression molding. And one end of the graphite-based flexible grounding strip is arranged in the grounding module body. One end of the water suction pipe is arranged in the grounding module body, and a plurality of water inlet micropores are distributed in a pipe body of the water suction pipe. According to the invention, a'graphite conductive network-water glass ion channel-bentonite water storage unit 'ternary synergistic system is constructed, and the water absorption pipe absorbs water and stores the water into the module, so that the module can still keep stable grounding resistance in a drought or freeze thawing environment, and meanwhile, flexible graphite production waste is adopted as a main raw material, so that the cost is reduced, and the production efficiency is improved. Through surface activation, particle size grading and interface optimization, 100% solid waste resource utilization is realized.

The invention relates to the technical field of all-vanadium redox flow batteries, in particular to a high-oxidation-resistance polybenzimidazole proton exchange membrane as well as a preparation method and application thereof. According to the proton exchange membrane, different polymeric monomers with high oxidation resistance are mixed in the reaction process to prepare a polybenzimidazole block copolymer, and after the membrane formed by the polybenzimidazole block copolymer is soaked in high-concentration acid liquor, rapid and selective conduction of protons is achieved. Aiming at the problems that in the application process of poly (2, 2 '-(p-oxybiphenyl)-5, 5'-benzimidazole) in an all-vanadium redox flow battery, a polymer skeleton is easily oxidized by VO < 2 + > ions, so that the battery capacity is attenuated, and the energy conversion efficiency is continuously reduced, the preparation method comprises the following steps: synthesizing a high-oxidation-resistance polybenzimidazole block copolymer main chain; the microphase separation structure of the polybenzimidazole block copolymer membrane can be effectively improved, a rapid ion channel is constructed in the polybenzimidazole block copolymer membrane, and meanwhile, the utilization rate of an acid solution is increased.

The invention discloses a high-stability salinity gradient power generation film, a preparation method and application thereof, and a self-supporting film with an ordered layered structure is prepared by compounding montmorillonite MMT nanosheets and nanocellulose and combining vacuum filtration and gradient drying processes. The MMT nanosheet layered structure provides a directional ion channel, the negative charge surface enhances the cation selectivity, the nanocellulose flexible network inhibits MMT stacking, and the hydrogen-bond interaction improves the interface bonding force. The power density of the thin film reaches 4-6 W / m (50 times of salinity difference), the tensile strength is larger than or equal to 20 MPa, and the power attenuation rate is smaller than or equal to 5% after the thin film continuously operates for 100 hours. The preparation process is green and controllable, is suitable for seawater-river water and industrial wastewater salinity gradient power generation scenes, and has large-scale application potential.

This invention belongs to the field of solid waste resource utilization and energy storage technology, specifically relating to a highly conductive, ion-uniformly distributed porous solid waste-fiber composite electrolyte and its preparation and application. Currently, cement-based electrolytes exhibit low ionic conductivity, small pore size, and poor connectivity. This invention involves bridging two copper meshes with fibers to form a chain-like aggregate structure, creating a three-dimensional framework. A mixed slurry of steel slag, mineral powder, and polymer microspheres is then filled into this framework. The polymer microspheres are then removed to create uniformly distributed pores, yielding the solid waste-fiber composite electrolyte. This invention utilizes industrial solid waste to prepare the electrolyte matrix, introduces fibers to form short-distance interconnected ion channels, and incorporates soluble polymer microspheres to create a controllable and uniformly distributed pore structure within the solid waste-fiber composite electrolyte, thereby improving the electrolyte's ionic conductivity. The prepared composite electrolyte can be used to assemble supercapacitors, achieving performance optimization.

The present invention discloses a far-infrared functional bioluminescent composite material, an acupuncture patch prepared from the composite material, and its application, belonging to the technical field of far-infrared medical materials. The bioluminescent composite material is composed of the following components by weight: 25-45 parts of modified Bianstone, 20-30 parts of medical stone, 10-20 parts of germanium stone, 5-10 parts of silicon dioxide, and 5-10 parts of aluminum oxide. The modified Bianstone is prepared by processes such as bentonite interlayer pore expansion, LaFe perovskite / TiO2 quantum dot intercalation, and Prussian blue analog loading. The composite material has far-infrared emission characteristics and can resonate with human tissue to absorb negative oxygen ions through quantum dot photocatalysis. The porous structure adsorbs inflammatory factors. The LaFe perovskite / TiO2 quantum dot photocatalysis synergizes with the far-infrared radiation of the Bianstone to destroy bacterial cell membranes; the medical stone releases trace elements to inhibit bacterial activity. The prepared acupuncture patch is compounded with a medical pressure-sensitive adhesive through a molding process to generate microcurrent to stimulate the TRPV1 ion channel, achieving the treatment of facial paralysis, hypertension, and diabetes.

This invention discloses an acaricide targeting calcium ion channels and its application, belonging to the field of pesticides. Specifically, it relates to an acaricide based on the L-type calcium ion channel (L-VGCC) target and its application in the control of agricultural mites. The acaricide, artemisinin [Formula (I)], is a natural coumarin compound that is highly effective against agricultural mites and safe against predatory mites. It is a targeted, natural, and environmentally friendly acaricide with minimal harm to humans and the environment, and has the potential to be developed into a selective acaricide.

The invention discloses an ordered ion channel polyamide nano composite membrane, a preparation method and application, relates to the field of lithium magnesium membrane separation, and aims to solve the problem of poor selectivity in the prior art. The technical scheme is as follows: amino benzo crown ether is covalently grafted on an ultrafiltration base membrane in situ through diazotization-coupling reaction; then, a polyamide compact layer is prepared on the crown ether nano layer subjected to in-situ self-assembly through interfacial polymerization, and the polyamide nano composite membrane with the ordered ion transmission channel is jointly constructed. The residual amino groups on the surface of the in-situ covalent grafted crown ether nano layer can also participate in interfacial polymerization reaction, so that the ordered ion channel crown ether macromolecular layer and the polyamide compact layer are connected through chemical bonds to jointly form the polyamide nano composite membrane with the ordered ion transmission channel. And the method is suitable for extracting lithium from the salt lake brine.

The invention discloses a method for quantifying response of two carbon utilization modes of microalgae to weathered carbon sink of magnesium-containing silicate rock, which comprises the following steps: culturing two groups of microalgae under the same culture condition, adding magnesium-containing silicate rock and microalgae into one group, and setting an inhibitor (AZ / DIDS) added with a certain carbon utilization mode as an experimental group; and only magnesium-containing silicate rock and microalgae are added into one group as a blank group without adding an inhibitor (AZ / DIDS) of a certain carbon utilization mode. Setting the treatment group added with AZ (10mM) and DIDS (2mM) as an experimental group, and subtracting the weathering quantity of the magnesium-containing silicate rocks in the treatment group not added with AZ / DIDS and the treatment group added with AZ / DIDS to obtain the weathering quantity delta Ti of the magnesium-containing silicate rocks under the influence of the microalgae anion channel utilization mode, namely delta Ti = Ti-Ti (AZ / DIDS), and rock weathering carbon sink Qi = delta Ti under the influence of the microalgae anion channel utilization mode. Fitting a polynomial function Q = Q (i) to obtain the response function of the microalgae extracellular carbonic anhydrase mode or the microalgae anion channel utilization mode to the weathering carbon sink of the magnesium-containing silicate rock. According to the method, the rock weathering carbon sink quantity under the influence of two carbon utilization modes of the microalgae can be rapidly and accurately obtained. The invention provides the method for quantifying the response of the two carbon utilization modes of the microalgae to the weathered carbon sink of the magnesium-containing silicate rock so as to overcome the defect that the response of the two carbon utilization modes of the microalgae to the weathered carbon sink of the magnesium-containing silicate rock cannot be quantified in the prior art.

Systems and techniques are provided for making genetically engineered ion channels (ICs) with bioluminescent resonance energy transfer (BRET) complexes and using such ICs for efficient readout of neural activity and output of biological neuronal networks.SOLUTION: In one implementation, the disclosed technology includes identifying a target location in the IC for expression of a target protein including a donor tag protein and an acceptor tag protein, and modifying the genome of the neuronal cell at a portion associated with the target location in the IC. The technique further includes causing the neuronal cell to express the target protein in the IC according to the modified genome. In the first (second) state of the IC, the donor tag protein is at a first (second) distance from the acceptor tag protein that is related to the absence (presence) of energy transfer between the donor tag protein and the acceptor tag protein.SELECTED DRAWING: Figure 3A-3C

The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.

This application discloses a self-cleaning electrolysis module and electrolysis equipment. The self-cleaning electrolysis module includes a shell and an electrolysis space within the shell. The electrolysis space is divided into a first chamber with a first electrode and a second chamber with a second electrode by a first separator. The first and second electrodes have opposite polarities and their polarities can be switched. The first separator is an ion channel for cations. The first chamber is provided with a first inlet pipe and a first outlet pipe, and the second chamber is provided with a second inlet pipe and a second outlet pipe. The first and second inlet pipes are arranged in parallel. When the electrode in any chamber is an anode, the inlet and outlet pipes of the current chamber are connected, and the inlet pipes of adjacent chambers are disconnected. The self-cleaning electrolysis module of this application can output electrolysis products with high redox potentials and can also achieve self-cleaning of scale in the chamber by switching electrode polarities.

Provided herein are depolarizing ion channel therapeutics and methods of using the same for treating retinal and neurodegenerative diseases.

The invention belongs to the technical field of plant genetic engineering, and particularly discloses a nitrate ion transport channel gene PbrSLAH3b and application of the nitrate ion transport channel gene PbrSLAH3b in promoting growth of pear pollen tubules. The method comprises the following steps: extracting total RNA (Ribonucleic Acid) of Dangshan pears from pollen of Dangshan pears; carrying out reverse transcription on the RNA to obtain cDNA (complementary deoxyribonucleic acid); and by taking the cDNA as a template, carrying out amplification to obtain the pear pollen tube nitrate transport channel gene PbrSLAH3b, the PbrSLAH3b gene provided by the invention belongs to a slow anion channel SLAC / SLAH family member, the PbrSLAH3b is remarkably up-regulated in expression in the early growth stage of a pollen tube, and the PbrSLAH3b is positioned in a plasma membrane. The invention verifies that PbrSLAH3b can form a functional anion channel with NO3 <-> selectivity under the condition of not depending on proton gradient or phosphorylation state, and the PbrSLAH3b has relatively strong selectivity on NO3 <->. Therefore, the PbrSLAH3b gene can mediate the absorption and transport of the pollen tube to NO3 <-> and maintain the polarity growth directivity of the pollen tube, and has important application value for revealing the ion regulation mechanism of the growth of the fruit tree pollen tube and improving the reproductive development of the fruit tree.

The invention provides a compound for regulating and controlling a TRPV1 ion channel. The structural formula of the compound is as shown in formula I. The invention also provides application of the compound in preparation of a medicine for regulating and controlling the TRPV1 ion channel. The invention provides a pharmaceutical composition with an anti-inflammatory effect, the pharmaceutical composition comprises the compound, and pharmaceutically acceptable auxiliary materials or auxiliary components are added to prepare a pharmaceutically common preparation. Compared with azobenzene, the compound has the advantages that the illumination wavelength is increased, the illumination wavelength is 660 nm, a TRPV1 targeted photosensitizer is used, a channel is activated by using a low-energy near-infrared light'precise key ', depth, safety and reversibility are considered, and the anti-inflammatory effect of the compound is obvious.

The application discloses an ion channel based on a poly-polypeptide skeleton and application thereof, and rational use of the poly-polypeptide main chain length difference of different polymerization degrees and the structure-activity relationship difference of different secondary structures of the poly-polypeptide is used in the poly-polypeptide ion channel of the application, the polymerization degree and the secondary structure of the poly-polypeptide are regulated, the length of the poly-polypeptide and the arrangement of the side chain functional groups are regulated, and then the opening or closing of the poly-polypeptide ion channel is regulated, a responsive poly-polypeptide ion channel is designed by introducing a suitable responsive group into the side chain of the poly-polypeptide, and therefore the tumor-specific activation of the poly-polypeptide ion channel is realized, and inspiration is provided for the design and application of the artificial ion channel.

The invention provides an energy-gathering electrode device for breaking large rocks through electric pulses and a using method, and relates to the technical field of breaking of large rocks. The device comprises. The device comprises a positive electrode connecting port, a negative electrode connecting port, a liquid injection port, a rubber sleeve, a plugging piece, an insulating piece, a negative electrode ring and a positive electrode cross electrode structure. A V-shaped energy-gathering groove is formed in the periphery of the insulating part; and the tip of the positive cross electrode structure extends to the edge of the energy-gathering groove. During use, water is injected into the rubber sleeve, then the rubber sleeve is placed in a rock drill hole, the distance between the negative electrode ring and the positive electrode cross electrode is adjusted, so that a directional plasma channel is formed in the energy gathering groove through discharge, generated shock waves are transmitted to rock through a water medium, and energy gathering and releasing are achieved. The invention solves the problems of energy dispersion and low efficiency in traditional electric pulse crushing, is particularly suitable for directional and efficient crushing of large rocks, and has the advantages of simplicity and convenience in operation, high energy utilization rate and environmental protection.

The invention relates to a compound which is effective in inhibiting the function of the TRPM4 ion channel and the use of such compound in treating or preventing a TRPM4-associated disorder in a subject such as neurodegenerative diseases like stroke, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and neurodegenerative disease under inflammatory conditions, in particular multiple sclerosis, or genodermatosis, cardiac diseases, and immunemediated diseases. The invention also provides a pharmaceutical composition comprising the TRPM4 inhibitory compound.

The application provides an active oxygen response type artificial ion channel, and a structural general formula is as follows: the application is activated by high level ROS in cancer cells, the activated channel promotes the synergistic transmembrane transmission of H + and Cl ‑ ions, thereby realizing specific anticancer treatment, the synthetic route of the application is green, simple, efficient, raw materials are easy to obtain, and can be used for synthesis of similar compounds.

Described herein are modified monoterpene TRPM8 activating compounds. In particular, provided herein are compounds that affect intracellular ion channel function, and are useful as or in conjunction with therapeutic agents. The compounds provided herein are useful in the treatment of a variety of diseases and disorders, including inflammatory eye diseases (e.g., uveitis), cardiovascular diseases, inflammatory diseases, and diseases characterized by aberrant hyperplasia (e.g., cancer).

The present invention discloses a molecular dynamics simulation analysis method for ultrasonic perturbation of the Piezo1 protein, belonging to the field of ultrasonic perturbation. In the molecular dynamics simulation, ultrasonic perturbation is achieved by applying an ultrasonic function to the boundary, and successful ultrasonic loading is verified based on the water density on the X-axis. Furthermore, an analytical method is established to explain the effects of ultrasound on cell membranes from multiple angles, such as cell membrane thickness and lipid-protein interactions, and further study the effects of cell membranes on proteins, thereby determining the effects of ultrasound on the Piezo1 structure. This invention is the first to use ultrasonic loading coarse-grained molecular dynamics simulation to study the conformational changes of the Piezo1 mechanosensitive ion channel, providing important research ideas for future applications in ultrasound therapy, acoustic genetics, and other fields.

The application belongs to the technical field of fuel cell application, and discloses a polynorbornene-based anion exchange ionomer with double-domain coupled ion channels, a preparation method and application thereof. The polynorbornene-based anion exchange ionomer simultaneously constructs an ion domain rich in cation groups and a synergistic functional domain rich in oxygen-containing functional groups at a molecular scale, the two types of domains are coupled with each other in the material and form a continuous double-domain ion transmission network, so that the ionomer can still maintain a stable and continuous hydrogen and oxygen ion transmission channel under the conditions of a thin layer state of a cathode catalyst layer and limited hydration, and effectively improves the ion transmission connectivity and catalyst utilization efficiency of the catalyst layer interface. The ionomer is suitable for being used as an ion-conducting bonding material of a cathode of an alkaline membrane fuel cell, can improve the oxygen reduction reaction performance of the cathode, and provides a new material and structural design idea for a low-noble metal loading and high-power density fuel cell electrode structure design.

The present invention discloses a novel anode layer ion source. The anode layer ion source prevents positive ions in the ion channel from bombarding the cathode surface by arranging outer shielding covers on the surfaces of the inner cathode and the outer cathode, thereby reducing metal atoms generated by sputtering, effectively suppressing cathode etching, and preventing sample contamination. At the same time, a magnetic shielding cover is arranged around the inner contours of the inner cathode and the outer cathode inside the ion source to shield the magnetic field near the anode, optimize the electromagnetic field distribution, reduce internal discharge, improve the stability of the process, and thus increase the working life of the anode layer ion source.

The invention discloses a high-conductivity alkaline anion exchange membrane and a preparation method thereof, the high-conductivity alkaline anion exchange membrane is prepared from a rigid aromatic monomer, reactive quaternized polyarylether sulfone, immobilized quaternary ammonium salt, hydrophobic mesoporous SiO2 and a cross-linking agent, and the surface of the high-conductivity alkaline anion exchange membrane is provided with a cation density gradient transition layer and an anti-corrosion coating. The alkali-resistant stability of the membrane is improved through covalent bonding of quaternary ammonium and a three-dimensional cross-linked structure, the mesoporous SiO2 regulates swelling and constructs an ion channel, and the interface contact resistance is reduced through a gradient structure. And the OH <-> conductivity at 80 DEG C reaches 149-168 mS / cm, the 4000 h alkali-resistant retention rate is greater than or equal to 90%, the in-plane swelling rate is less than or equal to 5.1%, the interface contact resistance is as low as 0.08 omega.cm < 2 >, and the composite material has the advantages of high conductivity, low swelling, high alkali resistance and excellent interface compatibility, and is suitable for alkaline fuel cells.

This invention provides a method for improving the antidepressant effect of an NMDAR pore channel blocker, comprising: (1) performing behavioral, pharmacological, or physical measures before or during the plasma half-life of the NMDAR pore channel blocker to open ion channels of a larger proportion of NMDAR molecules in the lateral habenula (LHb); and optionally (2) performing behavioral, pharmacological, or physical measures after administration of the NMDAR pore channel blocker to prevent or reduce the dissociation of NMDAR pore channel blocker molecules from NMDAR. Treatment regimens and drug combinations for effectively treating depression are also provided. This disclosure further provides a drug delivery system comprising an implantable unit capable of controlled, repeatable, and precise in vivo delivery of an NMDAR pore channel blocker, as well as an initiator and / or enhancer, to an LHb region of a subject's brain, thereby achieving improved therapeutic effects.