Aspects of the invention include methods of
managing pain in a subject by applying a transdermal delivery device containing a
dexmedetomidine composition formulated to deliver a pain relieving effective amount of
dexmedetomidine to a subject. In practicing methods according to certain embodiments, a transdermal delivery device having a
dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine effective to manage pain in the subject. In some embodiments, methods include hydrating the subject, such as by administering a hydration
fluid composition to the subject. Methods according to certain embodiments may also include co-administering an
opioid to the subject. Also provided is a transdermal delivery device configured to deliver dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery device.