2356results about "Spinal electrodes" patented technology

Provided are systems, devices, and methods for energy delivery to a patient to treat a medical condition. A system for delivering energy to a patient includes: a treatment device having one or more energy delivery elements. The treatment device can deliver energy, such as ultrasound energy, to a target location of the patient via the one or more energy delivery elements. The energy delivery to the target location treats a medical condition of the patient.

A catheter configured to deliver energy circumferentially around an anatomical lumen in which the catheter is positioned. The catheter includes an elongate structure configured to transform between a low-profile delivery state and a radially expanded deployed state. The elongate structure mechanically supports one or more electrodes configured to emit energy and includes an outer jacket comprising a polymer. The catheter defines a material boundary adjoining the outer jacket and at least one electrode to enable a mechanical adhesion between the polymer of the outer jacket and the electrode. In examples, the polymer intrudes into one or more volumes defined by asperities in a surface of the electrode to enable the mechanical adhesion. In examples, material boundary is formed by reflowing the polymer.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

Flexible high-density mapping catheter tips and flexible ablation catheter tips with onboard high-density mapping electrodes are disclosed. These tips can be used for diagnosing and treating cardiac arrhythmias. The flexible, distal tips are adapted to conform to tissue and comprise a plurality of microelectrodes mounted to permit relative movement among at least some of the microelectrodes. The flexible tip portions may comprise a flexible framework forming a flexible array of microelectrodes (for example, a planar or cylindrical array) adapted to conform to tissue and constructed at least in part from nonconductive material in some embodiments. The flexible array of microelectrodes may be formed from a plurality of rows of longitudinally-aligned microelectrodes. The flexible array may further comprise, for example, a plurality of electrode-carrying arms or electrode-carrier bands. Multiple flexible frameworks may be present on a single device. A delivery adapter having an internal compression cone is also disclosed.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

The delivery of neurostimulation to a subject using a closed-loop neurostimulation device (e.g., using a brain stimulation device to provide neurostimulation to a subject's brain) is controlled based on a global optimization-based temporal prediction framework. As a result, the brain stimulation device (e.g., a transcranial magnetic stimulation (“TMS”) device) is synchronized with the ongoing neural state (e.g., brain state) in real time. For instance, a brain recording is analyzed to extract the brain process of interest (e.g., frequency of brain oscillations) and used train a prediction algorithm. After that, a stimulation stage is implemented, in which the individual brain state is analyzed in real-time, the occurrence of the biomarkers (e.g., brain oscillation phase) is predicted, and the stimulation is triggered at the expected time.

The invention relates to the technical field of medical instruments, in particular to a nerve stimulation electrode based on a shape memory material. The nerve stimulation electrode comprises a flexible packaging electrode body and a substrate crease layer arranged on the surface of the flexible packaging electrode body. The material of the substrate crease layer comprises a shape memory polymer and a nano ferromagnetic material; the substrate crease layer comprises a first bending part which is used for enabling the flexible packaging electrode body to be folded along the length direction of the flexible packaging electrode body. The nerve stimulation electrode can solve the problems that an existing nerve stimulation electrode is hard in appearance, large in overall mass, poor in flexibility and complex in implantation operation.

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

A wireless implant and associated system for motor function recovery after spinal cord injury, and more particularly a multi-channel wireless implant with small package size. The wireless implant can further be used in various medical applications, such as retinal prostheses, gastrointestinal implant, vagus nerve stimulation, and cortical neuromodulation. The system also includes a method and its implementation to acquire the impedance model of the electrode-tissue interface of the implant.

A device and algorithm for controlling an autonomic function in an individual. A controller device that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure. A control interface and algorithm for controlling an autonomic function in a subject. For instance, an algorithm that utilizes physiological measurements (such as blood pressure) to regulate spinal cord electrical stimulation to stabilize blood pressure.

A neuromodulation system is provided herein. The system can include a cuff electrode, an electronics package, which can be part of a neuromodulation device; an external controller; a sensor; and a computing device. The neuromodulation device can include an antenna including an upper and a lower coil electrically connected to each other in parallel. The computing device can execute a closed-loop algorithm based on physiological sensed data relating to sleep.

Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and / or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and / or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and / or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

Methods and systems for testing and treating spinal cord stimulation (SCS) patients are disclosed. Patients are eventually treated with sub-perception (paresthesia free) therapy. However, supra-perception stimulation is used during “sweet spot searching” during which active electrodes are selected for the patient. This allows sweet spot searching to occur much more quickly and without the need to wash in the various electrode combinations that are tried. After selecting electrodes using supra-perception therapy, therapy is titrated to sub-perception levels using the selected electrodes. Such sub-perception therapy has been investigated using pulses at or below 10 kHz, and it has been determined that a statistically significant correlation exists between pulse width (PW) and frequency (F) in this frequency range at which SCS patients experience significant reduction in symptoms such as back pain. Beneficially, sub-perception stimulation at such low frequencies significantly lowers power consumption in the patient's neurostimulator.

An electrical stimulation lead includes electrodes disposed on a cuff body and arranged into at least a first row, a second row, and a third row, where the second row is disposed between the first and third rows, and each electrode in the first row is electrically coupled to a corresponding electrode in the third row. In another electrical stimulation lead the electrodes are arranged so that the first and third rows each include multiple electrodes and the second row, between the first and third rows, includes at least one electrode with each electrode in the second row at least twice as long as each of the electrodes of the first and third rows. In another electrical stimulation lead the electrodes are arranged so that each electrode in the first and third rows is at least twice as long as each of the electrodes of the second row.

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

A medical apparatus for a patient comprises an external system configured to transmit one or more transmission signals, each transmission signal comprising at least power or data; and an implantable system configured to receive the one or more transmission signals from the external system. The apparatus can be configured to treat a patient and / or record patient data. Methods of treating a patient and recording patient data are also provided.

The present disclosure provides systems and methods for providing neurostimulation therapy according to patient features. The patient features may be analyzed to develop a patient model between physiological and / or patient reported features and optimal settings for a neurostimulation therapy using machine learning operations. The model is trained using data corresponding to time intervals in which electrical pulses are applied to the patient, including video kinematic data, patient reported pain levels, implanted or worn sensor patient data, and stimulation parameters. The model is used to control ongoing neurostimulation therapy for the patient.

The disclosure describes devices and methods for providing transdermal electrical stimulation therapy to a subject including positioning a stimulator electrode over a glabrous skin surface overlying a palm of the subject and delivering electrical stimulation via a pulse generator transdermally through the glabrous skin surface and to a target nerve or tissue within the hand to stimulate the target nerve or tissue within the hand so that pain felt by the subject is mitigated. The pulses generated during the electrical stimulation therapy may include pulses of two different magnitudes.

Methods and systems for stimulation of the vagus nerve of a patient using a stimulation system is described herein. The stimulation system including a control module and at least one stimulation lead coupleable to the control module, the at least one stimulation lead including a plurality of electrodes. The method includes implanting the at least one stimulation lead percutaneously or through an opening in the carotid sheath with placement of the electrodes proximate to the vagus nerve for stimulation of the vagus nerve; implanting the control module remote from the vagus nerve; generating stimulation signals using the control module; and delivering the stimulation signals from the control module through at least one of the electrodes of the at least one stimulation lead to stimulate the vagus nerve of the patient.

Methods and apparatuses (e.g., devices and systems) for vagus nerve stimulation, including (but not limited to) sub-diaphragmatic vagus nerve stimulation. In particular, the methods and apparatuses described herein may be used to stimulate the posterior sub-diaphragmatic vagus nerve to treat inflammation and / or inflammatory disorders. The implantable microstimulators described herein may be leadless and batteryless.

Methods and systems are provided for treating chronic pain using spinal cord stimulation in combination with a neural recording device that records electrical signals from neural activity associated with chronic pain. Machine learning computational models are used to classify patterns of neural activity associated with various pain states and pain relief. Neural signatures of “chronic pain” and “pain relief” are used to assist with spinal cord stimulation programming to determine therapeutic stimulation parameters that achieve analgesia without paresthesia, the minimum stimulation amplitude needed for effective therapy, and to predict whether spinal cord stimulation is likely to be effective in relieving pain. A closed-loop therapy system is provided comprising a spinal cord stimulator that records brain electrical signals from neural activity associated with pain and automatically adjusts spinal cord stimulator settings to deliver electrical stimulation to the spinal cord when pre-specified patterns of neural activity associated with pain are detected.

One aspect of the present disclosure relates to a system for treating obstructive sleep apnea in a subject. The system can include a power source and a neuromuscular stimulator in electrical communications with the power source. The neuromuscular stimulator can include a controller and at least one electrode. The controller can be configured to receive certain power and stimulation parameters associated with a therapy signal from the power source. The at least one electrode can be configured to deliver the therapy signal to a target tissue associated with control of a posterior base of the tongue of the subject.

Disclosed herein are systems and methods for electrically modulating tissue. Systems can include a current generator; at least one implantable working electrode, the at least one implantable working electrode configured to be in electrical communication with the current generator; at least one indifferent electrode; and a controller configured to signal the current generator to: generate a set of currents with a set of initial polarities to be delivered to the working electrodes; and wherein the at least one indifferent electrode absorbs a bias current which is equal in magnitude and opposite in polarity to a summation of the set of currents.

At least some embodiments of the present disclosure are directed to systems and methods for managing sleep disordered breathing (e.g., obstructive sleep apnea) for a patient. A first implantable electrode delivers a first stimulation signal proximate to a first nerve of the patient to stimulate the first nerve and activate at least one first muscle for an upper airway dilation of the person. A second implantable electrode delivers a second stimulation signal proximate to a second nerve to stimulate the second nerve and activate at least one second muscle for a caudal tracheal traction for an upper airway of the person. A stimulation signal generator generates the first and second stimulation signals and coordinates the delivery of the first stimulation signal with the delivery of the second stimulation signal.

A cuff lead arrangement includes a first cuff lead having a first cuff body; first stimulation emitters (for example, electrodes) disposed on an interior surface of the first cuff body; a first lead body coupled to the first cuff body; first conductors electrically coupled to the first stimulation emitters and extending along the first lead body; and at least one first connection element. The cuff lead arrangement further includes a second cuff lead having a second cuff body; second stimulation emitters disposed on an interior surface of the second cuff body; a second lead body coupled to the second cuff body; second conductors electrically coupled to the second stimulation emitters and extending along the second lead body; and at least one second female connection element configured to receive the at least one first male connection element to conjoin the first cuff lead to the second cuff lead.

A closed-loop neuromodulation system, including an electrode array that is implantable to a brain of a subject, analog front-end device (AFD) for selectively selecting and reading a plurality of channels from electrode array, a finite impulse response (FIR) filter for selectively filtering signals from the AFD, a feature extraction engine (FEE) operatively connected to the FIR filter, configured to selectively extract features from signals provided by the FIR filter, a tree-structured hierarchical neural network classifier for detecting disease symptoms, and a multi-channel stimulator having high-voltage (HV) drivers operatively connectable to the electrode array.

A medical apparatus for a patient comprises an external system and an implantable system. The external system is configured to transmit one or more transmission signals, each transmission signal comprising at least power or data. The implantable system is configured to receive the one or more transmission signals from the external system, and to deliver stimulation energy to the patient. Methods of delivering stimulation energy are also provided.

An electrode that includes an elongate lead body and a nerve cuff. The nerve cuff may include a biologically compatible, elastic, electrically insulative cuff body configured to be circumferentially disposed around a nerve, first and second relatively wide electrically conductive contacts carried by the cuff body that are spaced from one another in the length direction and that extend in the width direction to such an extent that they extend completely around the cuff body inner lumen when the cuff body is in the pre-set furled shape, and a plurality of relatively narrow electrically conductive contacts carried by the cuff body that are spaced from one another in the width direction and are located between the first and second relatively wide electrically conductive contacts.

Techniques to help improve efficiency or effectiveness of treating a disorder such as RLS or PLMD, such as by issuing neural electrostimulations to a particular patient, while varying one or more amplitude parameters (e.g., at least one of electrostimulation current amplitude, electrostimulation voltage amplitude, or electrostimulation pulsewidth duration). A corresponding patient-subjective or patient-objective response can be observed. A characteristic electrostimulation intensity relationship can be generated, for example, based on the determined respective at least one of RLS or PLMD response indication threshold amplitude parameters and the plurality of corresponding neural electrostimulation durations. Once this characteristic electrostimulation intensity relationship has been generated, it can then be used to control issuing subsequent neural electrostimulations to the particular patient according to (1) at least one goal and (2) a variable operating point based upon the generated characteristic electrostimulation intensity relationship.

A system for closed-loop control of sub-perception spinal cord stimulation therapy is provided. The system includes an implantable pulse generator (IPG) with an evoked compound action potential (ECAP) recording module and accelerometer. A regression model maps accelerometer data to optimal stimulation parameters for consistent nerve activation. This enables closed-loop therapy in the sub-perception domain where ECAP features are not visually detectable. A clinician programmer applies the model and sub-perception dose to therapy programs deployed to the IPG. The model can be customized to each patient by collecting ECAP and accelerometer data. The mapping reconciles ECAP -based control between perception and sub-perception domains by supplementing unavailable ECAP data with accelerometer data. This improves stimulation therapies for patients receiving sub-perception and multi-sensor paresthesia treatments.