730results about "Spinal electrodes" patented technology

Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.

A medical apparatus for a patient comprises an implantable system. The implantable system comprises a first implantable device comprising: at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; and an implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters. The apparatus is configured to randomly vary at least one of the one or more stimulation parameters. Methods of providing stimulation energy with randomly varying stimulation parameters are also provided.

A neuromodulation lead that is biased towards a substantially omega shape when fully deployed is provided. The neuromodulation lead includes a left set of electrodes disposed on a left portion of the lead body of the neuromodulation lead and a right set of electrodes disposed on a right portion of the lead body of the neuromodulation lead. The neuromodulation lead can be positioned in the plane between the genioglossus muscle and the geniohyoid muscle.

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

A system for longitudinal assessment of nerve health includes a stimulator to deliver electrical stimuli proximate a target nerve, a sensor to detect muscle responses evoked by the stimuli, a display, and a processor in communication with the stimulator, sensor, and display. The processor controls delivery of the stimuli; determines, from the detected muscle response, one or more nerve-function parameters for the target nerve including at least a stimulation threshold; stores the parameters with a session identifier; retrieves parameters from multiple sessions to compute a longitudinal trend; and controls the display to present the trend together with an indication of the target nerve's status relative to a target range. The system supports objective session-to-session tracking to inform clinical decisions.

A neuromodulation system disclosed herein improves urethral function, provides personalized stimulating parameters, and allows the patients to regain control of their bladders according to several implementations. A neuromodulation system disclosed herein provides bilateral stimulation and sensing, and personalized machine learning classifiers for adaptive stimulation. The system may include one or more electrode leads implanted in a first lateral side of the patient and one or more second electrode leads implanted in a second lateral side of the patient opposite the first lateral side. Mixed urinary incontinence and other conditions are treated using electrical stimulation, according to several implementations.

A conductive hydrogel fiber including a hydrogel network formed from a water-soluble hydrogel polymer and conductive fillers dispersed therein is provided. The hydrogel network includes a porous structure having nanofibrillar network walls, the surfaces of which are provided with interconnected crystallized nanofibrils formed by concentration and aggregation of the hydrogel polymer. The conductive hydrogel fiber exhibits high electrical conductivity, excellent tensile strength, large elongation at break, high toughness, and low swelling in water.

The invention discloses a neural tissue stimulator, characterized in that the neural tissue stimulator comprises a multiple of microneedles and a chip comprising at least one comparator with adaptive level, sequence control circuit, at least one capacitor stack built by n capacitors and 2n switches, at least one buffer capacitor outside the at least one capacitor stack, at least two additional switches outside the at least one capacitor stack, a CMOS-Logic, wherein further, the neural tissue stimulator comprises an interposer layer comprising holes for the multiple of microneedles and a lid. The neural tissue stimulator is characterized in, that the chip is located on one surface of the interposer layer and that the lid and the interposer layer form a capsule for the chip. Further, the neural tissue stimulator is adapted to be electrically self-sufficient.

The present disclosure provides systems and methods for providing neurostimulation therapy according to gait features. The gait features may be analyzed to develop a patient model between gait features and optimal settings for a neurostimulation therapy using machine learning operations. The model is used to control ongoing neurostimulation therapy for the patient.

A neurostimulator implant is provided that includes a circuitry unit having first and second ends, a conducting side, and an opposing side. First and second electrodes are disposed on an outer surface of the circuitry unit so as to circumscribe the circuitry unit. Circuitry is disposed within the circuitry unit. An insulating member is disposed on the opposing side of the circuitry unit such that, on the opposing side, each electrode is covered by the insulating member by being sandwiched between a first side of the insulating member and the circuitry unit, such that the insulating member inhibits electrical conduction from the electrodes into tissue of a subject. A second side of the insulating member, opposite the first side, defines a generally flat side of the implant facing away from the first and the second electrodes of the circuitry unit. Other embodiments are also described.

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance / support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits.

Methods and systems for providing peripheral nerve stimulation are disclosed. Stimulation is delivered to a trunk of the nerve using electrodes configured at different circumferential locations about the nerve. Action potentials evoked by the stimulation within branches of the nerve are measured to map neural element within the trunk to the branches. The mapping can inform the selection of stimulation parameters that provide a therapeutic benefit and / or avoid unwanted side effects.

Systems, apparatuses, and methods described herein facilitate the placement of spinal cord stimulator (SCS) electrode in relationship to neural tissue of the spinal cord based on electromyography (EMG) data. The systems, apparatuses, and methods are designed to assist physicians and surgeons target specific neurophysiological locations through stimulation and subsequent visualization of EMG activity in response to stimulation to more precisely identify the location of the SCS electrodes that will maximize the intended therapeutics effects of SCS.

Selective high-frequency spinal cord modulation for inhibiting pain with reduced side effects and associated systems and methods are disclosed. In particular embodiments, high-frequency modulation in the range of from about 1.5 KHz to about 50 KHz may be applied to the patient's spinal cord region from an epidural, cervical location to address at least one of high back pain, mid-back pain, low back pain, and leg pain without creating paresthesia in the patient.

A method for manufacturing an implantable lead including an elongated lead body with a plurality of wires and an electrically isolating outer layer, wherein the method comprises:Providing a sleeve having a sealed end and an open cavity opposite the sealed end and including electrically conducting material;Pulling at least one wire out of the lead body;Positioning the pulled end of the at least one wire within the cavity of the sleeve;Forming the sleeve using a pressing tool such that the volume of the cavity is reduced, that the wire is fixed within the sleeve and that an electrical connection of the at least one wire and the formed sleeve is established;Attaching a contact element to the lead body such that the contact element fixes the formed sleeve at the lead body and establishes an electrical connection to the sleeve.

The present application relates to an apparatus (100) for stimulating a peripheral nerve. The apparatus comprises: an implantable electrode assembly (102), which can be implanted in the body of a patient, and is configured to apply a stimulation signal to a nerve. The implantable electrode assembly (102) comprises: a stimulation electrode (102a), which is fixed to a predetermined position of the body of the patient and is adjacent to a nerve therein, and is configured to operably apply a stimulation signal to the nerve; and an electrode circuit (102b), which is coupled to the stimulation electrode (102a), and is configured to receive stimulation energy in the form of an electromagnetic field, convert the stimulation energy into the stimulation signal and provide the stimulation signal to the stimulation electrode (102a), wherein the stimulation energy is from the outside of the implantable electrode assembly (102). The apparatus further comprises: a stimulation energy generator (104), which can be worn outside the body of the patient, so as to provide stimulation energy to the implantable electrode assembly (102) by means of electromagnetic field coupling. The stimulation energy generator (104) comprises: a generator circuit (658), which is used for generating stimulation energy in the form of an electromagnetic field; and a power source (660), which is coupled to the generator circuit (658), and is configured to supply power to the generator circuit (658).

An electrode apparatus may include a handle, a cannula extending from a distal end of the handle and having at least one lumen, a ground wire extending through the cannula, and an electrode wire extending through the handle and the cannula, the electrode wire being extendable and retractable relative to a distal end of the cannula. The apparatus may also include a hook, provided in the cannula, and being extendable and retractable relative to the cannula.

Apparatus and methods for treating back pain are provided, in which an implantable stimulator is configured to communicate with an external control system, the implantable stimulator providing a neuromuscular electrical stimulation therapy designed to cause muscle contraction to rehabilitate the muscle, restore neural drive and restore spinal stability; the implantable stimulator further including one or more of a number of additional therapeutic modalities, including a module that provides analgesic stimulation; a module that monitors muscle performance and adjusts the muscle stimulation regime; and / or a module that provides longer term pain relief by selectively and repeatedly ablating nerve fibers. In an alternative embodiment, a standalone implantable RF ablation system is described.

A system (10) for activating a sympathetic circuitry in response to electrical stimulation, comprising: at least one stimulation unit (14) comprising a lead (20) for electrical stimulation of a spinal cord, wherein the lead (20) is configured to stimulate functional cardiovascular hotspots in the spinal cord, and wherein the lead (20) comprises electrodes that are designed to target sympathetic pre- and post-ganglionic neurons responsible for blood pressure control.

The system includes an array of electrodes and a stimulator coupled to the array of electrodes by at least one flexible wire. The array of electrodes are disposed on a flexible carrier configured to wrap around a hypoglossal nerve of a patient. The array of electrodes include a first electrode, a second electrode, and a third electrode. The stimulator includes a control circuit configured to generate a stimulation signal. The stimulator is configured to receive a communication from an external device for selecting at least one of the first electrode, the second electrode, and the third electrode that will participate in stimulating the hypoglossal nerve of the patient.

Systems and methods for adjusting neural therapy patterns of a neuromodulation system in response to each of patient events and passage of time. Initial stimulation parameters are set and used to start a stimulation period. As time passes or events occur, the neuromodulation system adjusts the stimulation parameters according to a preset temporal pattern. Further examples include handling of patient requests for therapy changes, and acute testing for complex stimulation patterns.

The invention relates to a nerve interface device based on a transparent organic thin film transistor and a manufacturing method thereof. The device comprises a substrate, a first electrode layer comprising a plurality of source electrodes, a plurality of drain electrodes and a plurality of first electrodes, an organic semiconductor layer, a first insulating layer, a second electrode layer comprising a plurality of gate electrodes and a plurality of second electrodes, an interconnection wire layer, a biological electrode layer and a packaging layer which are sequentially arranged from bottom to top, a plurality of neural interface units are arranged in the device, each neural interface unit comprises a plurality of transistors, at least one capacitor and two biological electrodes, each transistor comprises a source electrode, a drain electrode, a gate electrode, an organic semiconductor layer and a first insulating layer between the transistor electrodes, two polar plates of each capacitor are respectively a first electrode and a second electrode which are opposite in position; the material of each layer of the device is a transparent flexible material. The device is low in cost, large in area, high in channel number, long in service life, and high in time and spatial resolution.

Simulation electrode assemblies for applying bilateral stimulation, for example stimulating both the left and right hypoglossal nerves of a patient in the treatment of sleep disordered breathing. In some methods, a stimulation electrode assembly is inserted through an incision at a side of the patient and implanted at a location extending across the patient's mid-line.

According to an aspect of the present inventive concept there is provided a system for determining an estimate of an anatomy of neural tissue of a subject. The system comprises an electrode arrangement comprising a plurality of electrodes, wherein different electrodes in the plurality of electrodes are configured to be arranged in different electrode locations adjacent the neural tissue, wherein the plurality of electrodes is configured to receive a plurality of stimulation signals, a sensor arrangement configured to generate indications of changes in at least one of a neural activity or a physiological activity in response to the stimulation signals and a processing unit, configured to receive data representing relations between the plurality of stimulation signals and the indications of changes in the neural activity or physiological activity, wherein the processing unit is configured to generate the estimate of the anatomy of the neural tissue of the subject.

Sensing an evoked response to electrical stimulation of target tissue of a patient in conjunction with an intra-luminal electrode. The intra-luminal electrode may be implanted in a blood vessel or similar lumen proximal to the target tissue and the sensed signals and / or delivered stimulation may pass through the blood vessel. or other lumen, walls. In some examples the evoked response may be an evoked compound action potential (ECAP), which may also be evoked resonant neural activity (ERNA). The electrical stimulation may elicit a measurable response indicative of a thought pattern or neural state that would otherwise be undetectable using a non-evoked biopotential.

Embodiments of the disclosure provide a device. The device comprises a body and a hook coupled to the body. The hook can be configured to receive a collar. The device comprises an arm coupled to the body. The collar can be positioned between the arm and the hook. The device comprises an actuator coupled with the hook. When the collar is in an open configuration, the collar can be positioned between and engaged by the hook and the arm. The collar can surround a peripheral nerve. From the open configuration, the actuator can be configured to pull the hook towards the body thereby forcing the collar to close around the peripheral nerve and force the collar into a closed configuration.

DC offset compensation is provided to equate the DC values of the inputs to sense amp circuitry used to sense tissue signals in a stimulator device. When a DC offset is present at the inputs to the sense amp circuitry, the stimulation circuitry is controlled to remove this DC offset, which can occur in different ways. In one example, charge imbalanced pulses are provided to the inputs of the sense amp circuitry, the stimulation electrodes, or to other electrodes. Control of the stimulation circuitry can occur using a DC offset compensation algorithm programmed into control circuitry of the stimulator device. Using the algorithm, measurements indicative of the DC offset are used to determine charge imbalanced pulses, with the measurements being made by shorting the inputs together, and then releasing the input to reestablish the DC offset.

Systems, devices, and techniques are configured to determine an electrode combination for delivering electrical stimulation. In one example, an IMD includes stimulation circuitry configured to deliver electrical stimulation to a target tissue via a first set of stimulation electrodes selected from a plurality of electrodes and sensing circuitry configured to sense a signal evoked by the electrical stimulation via a set of sensing electrodes selected from the plurality of electrodes. The IMD may also include processing circuitry configured to determine that the signal satisfies a threshold, responsive to determining that the signal satisfies the threshold, select the set of sensing electrodes as a second set of stimulation electrodes, and control the stimulation circuitry to deliver subsequent electrical stimulation via the second set of stimulation electrodes.