113 results about "Vagus nerve" patented technology

Method for reversing demyelination in a patient having a demyelinating disorder may include detecting one or more biomarkers for demyelination from the patient, receiving, in an implanted vagus nerve stimulator, a command to apply a remyelinating stimulation to the patient based on a level of the detected one or more biomarkers for demyelination; and applying electrical stimulation to the patient's vagus nerve from the implanted vagus nerve stimulator to reverse demyelination and increase remyelination of the patient's nerves. The electrical stimulation may be adjusted based on the level of the detected one or more biomarkers.

The invention discloses a sympathetic cervical spondylosis autonomic nerve regulation enhancing method based on a brain-computer interface, and relates to the technical field of nerve regulation and repair. According to the method, by synchronously collecting electroencephalogram and skin conductance signals and conducting time-frequency domain conjoint analysis and Lempel-Ziv complexity evaluation, accurate quantitative evaluation on sympathetic nerve activity and nerve disorder degree is achieved, double-model collaborative decision-making of machine learning and deep reinforcement learning is utilized, personalized nerve regulation parameters are intelligently generated, and the method has the advantages of being high in accuracy and high in accuracy. High-targeting and safe intervention is implemented through double-target hierarchical regulation and control aiming at neck sympathetic nerves and vagus nerves, and stimulation parameters are dynamically optimized in a closed-loop manner by adopting a genetic algorithm on the basis of real-time feedback of heart rate variability, skin conductance and autonomic nerve balance indexes, so that the stimulation accuracy is improved. Therefore, the sympathetic cervical spondylosis autonomic nerve regulation efficiency and effect are enhanced.

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

An auricular stimulation device having surface electrodes biased towards each other, and offset from one another, is provided. The stimulation device can be positioned about the ear of a patient with each of the electrodes overlaying auricular ear tissue containing innervation supplied by an auricular branch of the vagus nerve. The electrodes transcutaneously stimulate the auricular branch. Also provided is a method of treating a patient using the auricular stimulation device. The stimulation device can be used for treating patients with conditions such as high blood pressure, depression, high blood glucose level, and tinnitus. Also provided is a diagnostic and therapeutic system having the auricular stimulation device, a smart device and a monitoring device. The smart device controls the auricular stimulation device based on biomarker information received from the monitoring device; and on information related to the patient, such as age, musculoskeletal stability, etc.; and / or on user input.

In an illustrative embodiment, systems and methods for treating stress and / or for improving alertness in a subject using neurostimulation therapy include placing first electrode(s) on, over, or adjacent to an auricular branch of the vagus nerve, placing second electrode(s) on, over or adjacent to an auriculotemporal nerve, and delivering therapeutic stimulation pulses via the first electrode(s) and the second electrode(s) by delivering a first series of stimulation pulses to the first electrode(s), the first series configured to increase activity in neural medullary structure(s), and delivering a second series of stimulation pulses to the second electrode(s), the second series configured to increase activity in neural structures within the Trigeminocervical Complex.

1. Name of the product in this design: Body of a surface electrode. 2. Purpose of this design: The body surface electrode and its main body are used in conjunction with a nerve and muscle stimulator to stimulate the vagus nerve in the ear. 3. The key design features of this product are the shape of the main body of the surface electrode. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Other explanation: The dotted lines in the figure indicate the parts of this design that are not claimed.

The utility model discloses a kind of ear clip type electrodes for stimulating vagus nerve, including first clamping component, second clamping component and elastic piece, first clamping component is hinged with second clamping component, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, one end of elastic piece is clamped in the end of first clamping component away from first electrode end, the other end of elastic piece is clamped in the end of second clamping component away from second electrode end. First clamping component and second clamping component are elastically hinged by elastic piece, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, when ear clip type electrode for stimulating vagus nerve is clamped in user ear, first electrode end and second electrode end accurately contact with user ear, and by using clamping type fixing mode, it is not easy for ear clip type electrode for stimulating vagus nerve to slip, and effectively reduce the foreign body sensation of wearing.

Apparatus for stimulating a cervical vagus nerve including a neck band attachable to a human neck, a therapy module attached to said neck band wherein said neck band positions said therapy module over a cervical vagus nerve, an ultrasound transducer within said therapy module, and a driver circuit configured to excite said ultrasound transducer to apply ultrasonic energy to said cervical vagus nerve. A force-limiting mechanism including a spring-loaded subframe prevents damage to blood vessels adjacent to said cervical vagus nerve. The apparatus operates at low voltages of 5 volts or less suitable for portable battery-powered operation and provides pulsed ultrasonic energy for therapeutic stimulation.

The invention discloses a vagus nerve stimulator, and relates to the field of medical equipment, and the vagus nerve stimulator comprises a flexible substrate, and an energy collection module, a sensing module and a pulse transmitting module which are all disposed on the flexible substrate. The energy collecting module is connected with the sensing module and the pulse transmitting module. The energy collection module and the sensing module are both wrapped on the left carotid artery; the energy collection module is used for converting mechanical energy generated by relaxation and contraction of the left carotid artery, the temperature difference between the interior of the human body and the skin surface, the temperature difference between the interior of the human body and the environment or chemical energy in the human body into electric energy. The sensing module is used for collecting left carotid artery pressure; the pulse transmitting module is used for generating electric pulses according to the left carotid artery pressure collected by the sensing module and conducting electric pulse stimulation on the left vagus nerve. According to the application, self-power supply is achieved, epilepsy is actively prevented, only the neck needs to be cut open, and the situation that the infection risk of a patient is increased due to double-incision wounds is avoided.

The invention relates to the technical field of medical data processing and intelligent decision-making, in particular to an auxiliary decision-making data processing system for a pediatric hip joint surgery anesthesia scheme, which comprises a multi-dimensional state acquisition module for synchronously acquiring perioperative period physiological signs and environmental event data; the causal decoupling analysis module is used for decomposing the physiological signal fluctuation into nociceptive stimulation, drug inhibition and volume deficiency components; the compensatory reserve evaluation module is used for generating a quantized system compensatory reserve index based on the causal attribution vector; the risk game decision module is used for constructing a multi-target dynamic game model and generating a control strategy according to an interval where an index is located; the proportion optimization output module is used for calculating dynamic proportion parameters aiming at different regulation and control variables and generating a decision instruction; according to the method and the system, latent hemorrhage or vagus nerve reflex can be effectively identified, wrong medication during compensation depletion is avoided, and the safety of a high-risk operation is remarkably improved.

1. The name of the design product: neck stimulator. 2. The use of the design product: stimulator for stimulating the vagus nerve of the neck by ultrasound. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to a portable electrical stimulation device integrating vagus nerve-trigeminal nerve stimulation, and relates to the technical field of medical electrical stimulation equipment, the portable electrical stimulation device comprises a neck ring body, a heating electrical stimulation assembly and a main storage bag, the heating electrical stimulation assembly is arranged on the outer surface of the neck ring body, and the main storage bag is arranged at the bottom of the right side of the neck ring body. The auxiliary storage bag is arranged at the bottom of the left side of the neck ring body, the heating electrical stimulation assembly accurately corresponds to the three-fork two-type nerve branch area, the sleep state can be more comprehensively improved and sleep disorders can be relieved through cooperation of the heating electrical stimulation assembly and the three-fork two-type nerve branch area, blood circulation of a target area is promoted through synchronous heating, and the nerve excitation threshold value is reduced. According to the device, long-term nerve regulation and control can be better carried out by a user, a connecting cable is stored through the main storage bag and the auxiliary storage bag, the cable is prevented from being knotted or damaged due to extrusion, the arrangement time before use is shortened, and meanwhile, a magnetic attraction piece is utilized to attract a mounting piece of the heating electrical stimulation assembly, so that the whole device is more compact and regular when carried.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

The utility model relates to the field of design of medical equipment, in particular to an electrical stimulation device for ear vagus nerves, which comprises a winding part. A winding part is arranged outside the wire, the winding part comprises a wire spool, a wire winding wheel and an adjusting part, the wire spool sleeves the wire, the wire winding wheel is rotatably arranged in the wire spool, an extension part of the wire is wound on the wire winding wheel, the adjusting part is rotatably arranged on one side of the outer part of the wire spool, and the end part of the adjusting part penetrates through the wire spool and is connected with the wire winding wheel. According to the utility model, through the cooperation of the wire spool, the reel, the vortex spring and the adjusting piece, automatic winding and neat storage of wires are realized, and the problem of disorder of the wires is avoided; the ear support and the torsion spring are matched to ensure that the electrode is in close contact with the skin of the ear, so that the electrical stimulation effect is improved.

There is disclosed a system for providing transcutaneous electrical stimulation to the vagus nerve of an individual comprising: an electrode unit mountable within the auricle of the individual and having at least a first electrode and a second electrode for applying the transcutaneous electrical stimulation at the cymba conchae and the tragus of the individual's auricle, and a controller for controlling the transcutaneous electrical impulse delivered by each of the first electrode and second electrode.

The utility model relates to the field of ear vagus nerve stimulators, and discloses a firmly worn ear vagus nerve stimulator for atrial fibrillation, which comprises a main body, a connecting wire is fixedly arranged on the upper end face of the main body, a wearing module is clamped on the upper end face of the connecting wire, and a connecting module is sleeved on the rear end face of the main body in a threaded manner. The main body comprises a pulse generator, threaded openings are formed in the two sides of the rear end face of the pulse generator, the connecting module comprises a connecting plate, and sliding clamping plates are arranged on the two sides of the connecting plate in a sliding mode. During use, a connecting module is arranged on the rear end face of the main body and provided with a sliding clamping plate, the sliding clamping plate can fix a fixing belt to the rear end face of the main body, the equipment is convenient to carry, the connecting module is provided with a connecting plate, and a first fixing block connected in the connecting plate can be connected with a telescopic rod; damping rotating rods are arranged on the lower end faces of the telescopic rods.

In an illustrative embodiment, methods and system for increasing coagulation potential and / or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

The utility model relates to the technical field of medical instruments, and discloses a vagus nerve stimulator suspension device which comprises a protection box, a box cover, a plate sleeve, a connecting plate and a fixing assembly. A long bandage is fixed to the top end of one side of the protection box through a bolt, and a hook-and-loop fastener sub-face is sewn to one side of the long bandage; the short bandage is fixed to the bottom end of one side of the protection box through bolts, the hook-and-loop fastener female face is sewn to one side of the short bandage, the plate sleeve is fixedly arranged on the side, away from the long bandage, of the protection box, the top end of the plate sleeve is sleeved with the connecting plate, the box cover is fixedly arranged on one side of the connecting plate, and the fixing assemblies are arranged on the two sides of the plate sleeve. The fixing assembly comprises sleeves arranged on the two sides of the plate sleeve at equal intervals. The ear nerve stimulator is arranged in the protection box and is fixed on the shoulder of a user through the long bandage and the short bandage, so that the ear nerve stimulator can be effectively protected, the movement and movement of the user cannot be influenced after the ear nerve stimulator is fixed, and the ear nerve stimulator is suitable for wide popularization and use.

The application discloses a closed-loop charging regulation system based on a vagus nerve stimulator. The implantable vagus nerve stimulator comprises a motion sensing module for collecting user body motion signals in real time, a temperature sensing module for collecting user temperature signals, an electrocardiogram sensing module for collecting user electrocardiogram signals, and a first communication module for transmitting various signals; a wireless charging positioner performs wireless charging on the implantable vagus nerve stimulator; and an external program-controlled charger comprises a charging management module, which identifies the current conscious state and somatic perception state of the user, generates differentiated charging regulation instructions, and transmits the charging regulation instructions to the wireless charging positioner, so that the wireless charging positioner performs wireless charging on the implantable vagus nerve stimulator according to the charging regulation instructions. The closed-loop charging regulation system based on the vagus nerve stimulator has the advantages of timely responding to discomfort caused by charging, avoiding overcharging, ensuring charging safety, improving charging efficiency and user experience, and the like.

To regulate the number of peripheral regulatory T cells in the intestinal tract and to provide a new means for treating diseases associated with the cells.SOLUTION: A therapeutic agent for a disease, comprising a substance having an effect of regulating the amount of peripheral regulatory T cells in the intestinal tract, wherein the substance is a substance that activates or suppresses the hepatic vagal afferent pathway, a substance that activates or suppresses the left vagal efferent pathway, or an agonist or antagonist of a muscarinic acetylcholine receptor.SELECTED DRAWING: None

The invention provides an ear mold for assisting an electric acupuncture apparatus, relates to the technical field of medical instruments, and solves the technical problems that in the prior art, an electric acupuncture apparatus cannot effectively stimulate a vagus nerve area of an external auditory canal, and a structure for assisting in treating the area of the external auditory canal is lacked. The device comprises an ear mold body and a conductive filament, the conductive filament is wound on the outer wall of the ear mold body, the ear mold body can stretch into an external auditory canal of a patient, and the conductive filament wound on the ear mold body can be close to or make contact with the external auditory canal; when the ear mold of the auxiliary electric acupuncture apparatus is used, the end of the conductive filament is connected to one metal clip on the electric acupuncture apparatus, the other metal clip on the electric acupuncture apparatus is connected with an acupuncture needle, and the conductive filament, the electric acupuncture apparatus, the acupuncture needle and the body of a patient form an electric acupuncture loop.

The present application relates to a kind of based on motor imagination trigger's electric stimulation synchronous closed loop multimodal neuroregulation system, belong to medical rehabilitation engineering and neural engineering technical field.The system includes: electroencephalogram signal acquisition and processing module, for real-time acquisition user sensory motor cortex electroencephalogram signal, and extract the event-related desynchronization features of motor imagination task in the electroencephalogram signal by time-frequency analysis model;Motor intention recognition and trigger module generates synchronous trigger signal;Functional electric stimulation module, through multi-channel electrode device drive surface electrode output electric stimulation pulse to target area, drive target action;Transcutaneous auricular vagus nerve electric stimulation module, output and motor intention duration synchronous stimulation pulse;Central control and synchronization module, for coordination control timing.Formed " intention recognition-synchronous control-assisted movement" complete closed loop, provides a kind of efficient, accurate, individualized neural engineering solution.

A headset apparatus for a user comprising an ultrasound transducer mounted to the headset apparatus, wherein the ultrasound transducer is configured to press against the auricular vagus nerve, a coupling fluid on the surface of the transducer permitting ultrasonic energy to pass into human skin and, a cannabinoid extract in solution with the coupling fluid.

Methods for activating a person's autonomic nervous system may include: electrically coupling a first electrode to a vagus nerve via a transdermal coupling at a location rostral to the human's thoracic spine; electrically coupling a second electrode to a nerve in communication with the same vagus nerve or a different vagus nerve via a transdermal coupling at a site caudal to the human's cervical spine; and applying a therapeutic current waveform to cause current flow between the first and second electrodes and along at least a portion of the vagus nerve or nerves between the first and second electrodes. Apparatuses are disclosed for performing the methods.

The invention discloses an ear clip type ultrasonic vagus nerve regulation and control device and a control method thereof, and belongs to the technical field of biomedical engineering and wearable equipment. The device adopts a shell assembly imitating a TWS earphone, and an ultrasonic transducer, a driving circuit module, an optical auxiliary positioning module, a monitoring module, a control module and the like are highly integrated in the shell assembly. The method is characterized in that a system unlocks ultrasonic stimulation only when an optical positioning result is confirmed to be valid by a user, so that the accuracy of a target spot is ensured; in the stimulation process, automatic safety protection is executed by monitoring the temperature and the contact state in real time. According to the control method, subjective feedback and objective monitoring data of a user are fused, and personalized self-adaptive adjustment of stimulation parameters is achieved. The problems that traditional equipment is heavy, inaccurate in positioning and lack of intelligent safety control are solved, and an accurate, safe and comfortable ultrasonic nerve regulation and control solution capable of being worn daily is provided.

The present invention relates to a headset comprising a bilateral multimodal stimulator system for the non-invasive wireless stimulation of the trigeminocervical complex and the vagus nerve. In addition, the invention is controlled by a mobile application and / or compute, to enable the monitoring of the neurostimulation parameters as well as physiological data of the patients. The use of magnetic, electrical and mechanical stimulation of most of the nerves involved in pain processing and mood, may be used for the treatment, prevention or prophylaxis of neurological and psychiatric disorders like e.g., headache, migraine, chronic pain and depression.

The invention relates to the field of medical equipment, in particular to a nerve stimulator and an output control method thereof, and the nerve stimulator comprises a signal generation unit which is used for outputting an initial signal; the signal output unit is connected with the signal generation unit and used for outputting a stimulation signal according to the initial signal, and the stimulation signal acts on the neck vagus nerve; the frequency range of the stimulation signal is 5 KHz and 20 KHz. The nerve stimulator does not stimulate other nerves, and a better treatment effect is achieved.

The invention relates to the technical field of medicines, in particular to application of a GLP-1 receptor agonist in preparation of a medicine for treating obstructive sleep apnea. The medicine is used for treating obstructive sleep apnea by activating Glp1r < + > neurons in vagus ganglions, the hypopnea index of apnea can be remarkably reduced, the longest apnea duration is shortened, and a new treatment approach is provided for treating obstructive sleep apnea.

The application discloses a pre-meal nerve electric stimulation control method, device and system. The method comprises the following steps: detecting whether a pre-meal intervention condition is met; when the pre-meal intervention condition is met, generating a biphasic pulse electric stimulation by calling preset output parameters, wherein the preset output parameters comprise a constant stimulation frequency, a constant stimulation pulse width and a stimulation current; and controlling an electrode sheet to output the biphasic pulse electric stimulation to a target vagus nerve site. By outputting the biphasic pulse electric stimulation to the target vagus nerve site when the pre-meal intervention condition is met, the target vagus nerve can be quickly activated before a meal, the body is prepared for adjusting insulin secretion in advance, the postprandial blood glucose peak value can be more effectively flattened, the intervention effect is improved, and thus standard weight management is realized.