146 results about "Vagus nerve" patented technology

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

Methods and systems for stimulation of the vagus nerve of a patient using a stimulation system is described herein. The stimulation system including a control module and at least one stimulation lead coupleable to the control module, the at least one stimulation lead including a plurality of electrodes. The method includes implanting the at least one stimulation lead percutaneously or through an opening in the carotid sheath with placement of the electrodes proximate to the vagus nerve for stimulation of the vagus nerve; implanting the control module remote from the vagus nerve; generating stimulation signals using the control module; and delivering the stimulation signals from the control module through at least one of the electrodes of the at least one stimulation lead to stimulate the vagus nerve of the patient.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The invention provides a nerve electrical stimulation method, device and system based on electroencephalogram signals, and the method comprises the steps: obtaining pain related features in real time, the pain related features comprising electroencephalogram index features and heart rate variability features; generating a comprehensive pain score value in real time based on the pain related characteristics, and generating an electrical stimulation parameter in real time based on a target difference value between the comprehensive pain score value and the baseline score value; the vagus nerve of the patient is electrically stimulated based on the electrical stimulation parameters. The problem that in the prior art, due to immobilization of electrical stimulation parameters, dynamic adjustment cannot be conducted according to real-time neural activity of a patient, and therefore the treatment effect is affected is solved.

Method for reversing demyelination in a patient having a demyelinating disorder may include detecting one or more biomarkers for demyelination from the patient, receiving, in an implanted vagus nerve stimulator, a command to apply a remyelinating stimulation to the patient based on a level of the detected one or more biomarkers for demyelination; and applying electrical stimulation to the patient's vagus nerve from the implanted vagus nerve stimulator to reverse demyelination and increase remyelination of the patient's nerves. The electrical stimulation may be adjusted based on the level of the detected one or more biomarkers.

The utility model relates to the technical field of medical equipment, discloses a non-invasive ear vagus nerve stimulator, and solves the problems that a stimulator and a stimulating electrode of a conventional ear vagus nerve stimulator need to prop open an auricular concha area, so that a patient is prone to generating ear pressing pain, and subsequent normal treatment is affected. Through the elastic force of the C-shaped elastic column, clamping force is generated between the stimulator body and the flexible clamping block which are connected with the C-shaped elastic column, the stimulator body and the flexible clamping block are clamped on the front face and the back face of the ear respectively, the stimulator body is fixed to the position of the auricular conchae, a discharging head on the electrode mechanism can be attached to the auricular conchae conveniently, and the electrode column is elastically supported through the rubber column. According to the ear protection device for the auricular conchae, the rubber columns elastically support the electrode columns, so that when the ear protection device is used for coping with the ears of different patients, the rubber columns can adaptively deform, and the discharge heads on the surfaces of the electrode columns can be better attached to the auricular conchae.

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

Embodiments treat inflammation of a user by applying a first patch on a dermis of the user adjacent to an afferent nerve, the first patch comprising first electrodes, and applying a second patch on the dermis of the user adjacent to a vagus nerve or a vagus nerve connecting branch, the second patch comprising second electrodes. Embodiments generate a treatment protocol during a time period comprising simultaneously applying a first electrical stimuli to the afferent nerve via the first electrodes of the first patch and applying a second electrical stimuli to the vagus nerve or the vagus nerve connecting branch via the second electrodes of the second patch.

A bilateral auricular nerve stimulation system of the vagus nerve, which comprises two adjustable stimulator devices (4) in each ear respectively where each one comprises a support piece (5) with a curved temple (6); three or more cathodal stimulation electrodes simultaneously, with a first and second electrode (1, 2) that fit into the cymba and cavum respectively and a third electrode (3) that fits into the external auditory canal (EAC), where all electrodes are connected to one or more anodes (32), and have means of adjustment to their area of action; a photoplethysmography biosensor (PPG) (7) located at the free end of the curved temple (6), and; control means inside the support piece (5); where the system comprises a connection and synchronization cable between both stimulator devices.

In an illustrative embodiment, an apparatus for controlling or reducing stress levels includes an ear-mounted device having an earpiece for positioning over a wearer's ear contacting tissue regions surrounding the ear, and electrodes for delivering non-piercing neurostimulation, with first electrode(s) arranged on a first surface of the earpiece to contact a first tissue region, and second electrode(s) are arranged on a second surface to contact a second tissue region. The auricular branch of the vagus nerve or the auriculotemporal nerve is situated beneath the first tissue region. The apparatus includes a controller to deliver therapeutic stimulation pulses via the stimulation device, where the pulses in combination with the positioning of the first electrode(s) and the second electrode(s) are configured to modulate the activity ratio between the sympathetic nervous system and the parasympathetic nervous system, thereby increasing vagal tone.

The invention discloses a sympathetic cervical spondylosis autonomic nerve regulation enhancing method based on a brain-computer interface, and relates to the technical field of nerve regulation and repair. According to the method, by synchronously collecting electroencephalogram and skin conductance signals and conducting time-frequency domain conjoint analysis and Lempel-Ziv complexity evaluation, accurate quantitative evaluation on sympathetic nerve activity and nerve disorder degree is achieved, double-model collaborative decision-making of machine learning and deep reinforcement learning is utilized, personalized nerve regulation parameters are intelligently generated, and the method has the advantages of being high in accuracy and high in accuracy. High-targeting and safe intervention is implemented through double-target hierarchical regulation and control aiming at neck sympathetic nerves and vagus nerves, and stimulation parameters are dynamically optimized in a closed-loop manner by adopting a genetic algorithm on the basis of real-time feedback of heart rate variability, skin conductance and autonomic nerve balance indexes, so that the stimulation accuracy is improved. Therefore, the sympathetic cervical spondylosis autonomic nerve regulation efficiency and effect are enhanced.

The invention belongs to the technical field of diagnostic data processing, and particularly relates to a percutaneous ear vagus nerve electrical stimulation and disturbance of consciousness correlation qualitative analysis method and system. The consciousness state of the patient can be reflected more comprehensively by constructing the feature information of the standard consciousness evaluation index data distribution data, in addition, influence factors of drug therapy and diseases and lesions can be identified and eliminated more accurately through corresponding verification of the electrical stimulation signal abnormal fluctuation value, and the accuracy of the diagnosis result is improved. Therefore, the accuracy and effectiveness of pathogenesis analysis of the patient are improved, and medical resources can be reasonably distributed and used; the invention further provides a percutaneous ear vagus nerve electrical stimulation and disturbance of consciousness correlation qualitative analysis system and electronic equipment.

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

An auricular stimulation device having surface electrodes biased towards each other, and offset from one another, is provided. The stimulation device can be positioned about the ear of a patient with each of the electrodes overlaying auricular ear tissue containing innervation supplied by an auricular branch of the vagus nerve. The electrodes transcutaneously stimulate the auricular branch. Also provided is a method of treating a patient using the auricular stimulation device. The stimulation device can be used for treating patients with conditions such as high blood pressure, depression, high blood glucose level, and tinnitus. Also provided is a diagnostic and therapeutic system having the auricular stimulation device, a smart device and a monitoring device. The smart device controls the auricular stimulation device based on biomarker information received from the monitoring device; and on information related to the patient, such as age, musculoskeletal stability, etc.; and / or on user input.

In an illustrative embodiment, systems and methods for treating stress and / or for improving alertness in a subject using neurostimulation therapy include placing first electrode(s) on, over, or adjacent to an auricular branch of the vagus nerve, placing second electrode(s) on, over or adjacent to an auriculotemporal nerve, and delivering therapeutic stimulation pulses via the first electrode(s) and the second electrode(s) by delivering a first series of stimulation pulses to the first electrode(s), the first series configured to increase activity in neural medullary structure(s), and delivering a second series of stimulation pulses to the second electrode(s), the second series configured to increase activity in neural structures within the Trigeminocervical Complex.

1. Name of the product in this design: Body of a surface electrode. 2. Purpose of this design: The body surface electrode and its main body are used in conjunction with a nerve and muscle stimulator to stimulate the vagus nerve in the ear. 3. The key design features of this product are the shape of the main body of the surface electrode. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Other explanation: The dotted lines in the figure indicate the parts of this design that are not claimed.

The utility model discloses a kind of ear clip type electrodes for stimulating vagus nerve, including first clamping component, second clamping component and elastic piece, first clamping component is hinged with second clamping component, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, one end of elastic piece is clamped in the end of first clamping component away from first electrode end, the other end of elastic piece is clamped in the end of second clamping component away from second electrode end. First clamping component and second clamping component are elastically hinged by elastic piece, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, when ear clip type electrode for stimulating vagus nerve is clamped in user ear, first electrode end and second electrode end accurately contact with user ear, and by using clamping type fixing mode, it is not easy for ear clip type electrode for stimulating vagus nerve to slip, and effectively reduce the foreign body sensation of wearing.

Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from the pancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.

Apparatus for stimulating a cervical vagus nerve including a neck band attachable to a human neck, a therapy module attached to said neck band wherein said neck band positions said therapy module over a cervical vagus nerve, an ultrasound transducer within said therapy module, and a driver circuit configured to excite said ultrasound transducer to apply ultrasonic energy to said cervical vagus nerve. A force-limiting mechanism including a spring-loaded subframe prevents damage to blood vessels adjacent to said cervical vagus nerve. The apparatus operates at low voltages of 5 volts or less suitable for portable battery-powered operation and provides pulsed ultrasonic energy for therapeutic stimulation.

The invention discloses a vagus nerve stimulator, and relates to the field of medical equipment, and the vagus nerve stimulator comprises a flexible substrate, and an energy collection module, a sensing module and a pulse transmitting module which are all disposed on the flexible substrate. The energy collecting module is connected with the sensing module and the pulse transmitting module. The energy collection module and the sensing module are both wrapped on the left carotid artery; the energy collection module is used for converting mechanical energy generated by relaxation and contraction of the left carotid artery, the temperature difference between the interior of the human body and the skin surface, the temperature difference between the interior of the human body and the environment or chemical energy in the human body into electric energy. The sensing module is used for collecting left carotid artery pressure; the pulse transmitting module is used for generating electric pulses according to the left carotid artery pressure collected by the sensing module and conducting electric pulse stimulation on the left vagus nerve. According to the application, self-power supply is achieved, epilepsy is actively prevented, only the neck needs to be cut open, and the situation that the infection risk of a patient is increased due to double-incision wounds is avoided.

The invention relates to the technical field of medical data processing and intelligent decision-making, in particular to an auxiliary decision-making data processing system for a pediatric hip joint surgery anesthesia scheme, which comprises a multi-dimensional state acquisition module for synchronously acquiring perioperative period physiological signs and environmental event data; the causal decoupling analysis module is used for decomposing the physiological signal fluctuation into nociceptive stimulation, drug inhibition and volume deficiency components; the compensatory reserve evaluation module is used for generating a quantized system compensatory reserve index based on the causal attribution vector; the risk game decision module is used for constructing a multi-target dynamic game model and generating a control strategy according to an interval where an index is located; the proportion optimization output module is used for calculating dynamic proportion parameters aiming at different regulation and control variables and generating a decision instruction; according to the method and the system, latent hemorrhage or vagus nerve reflex can be effectively identified, wrong medication during compensation depletion is avoided, and the safety of a high-risk operation is remarkably improved.

1. The name of the design product: neck stimulator. 2. The use of the design product: stimulator for stimulating the vagus nerve of the neck by ultrasound. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The invention relates to a portable electrical stimulation device integrating vagus nerve-trigeminal nerve stimulation, and relates to the technical field of medical electrical stimulation equipment, the portable electrical stimulation device comprises a neck ring body, a heating electrical stimulation assembly and a main storage bag, the heating electrical stimulation assembly is arranged on the outer surface of the neck ring body, and the main storage bag is arranged at the bottom of the right side of the neck ring body. The auxiliary storage bag is arranged at the bottom of the left side of the neck ring body, the heating electrical stimulation assembly accurately corresponds to the three-fork two-type nerve branch area, the sleep state can be more comprehensively improved and sleep disorders can be relieved through cooperation of the heating electrical stimulation assembly and the three-fork two-type nerve branch area, blood circulation of a target area is promoted through synchronous heating, and the nerve excitation threshold value is reduced. According to the device, long-term nerve regulation and control can be better carried out by a user, a connecting cable is stored through the main storage bag and the auxiliary storage bag, the cable is prevented from being knotted or damaged due to extrusion, the arrangement time before use is shortened, and meanwhile, a magnetic attraction piece is utilized to attract a mounting piece of the heating electrical stimulation assembly, so that the whole device is more compact and regular when carried.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

The utility model relates to the field of design of medical equipment, in particular to an electrical stimulation device for ear vagus nerves, which comprises a winding part. A winding part is arranged outside the wire, the winding part comprises a wire spool, a wire winding wheel and an adjusting part, the wire spool sleeves the wire, the wire winding wheel is rotatably arranged in the wire spool, an extension part of the wire is wound on the wire winding wheel, the adjusting part is rotatably arranged on one side of the outer part of the wire spool, and the end part of the adjusting part penetrates through the wire spool and is connected with the wire winding wheel. According to the utility model, through the cooperation of the wire spool, the reel, the vortex spring and the adjusting piece, automatic winding and neat storage of wires are realized, and the problem of disorder of the wires is avoided; the ear support and the torsion spring are matched to ensure that the electrode is in close contact with the skin of the ear, so that the electrical stimulation effect is improved.

The invention discloses an experimental method for relieving ferroptosis of cerebral apoplexy rats through tVNS, and relates to the technical field of nerve regulation and control. Comprising the following steps: S1, constructing a rat MCAO model, and constructing an SD rat right cerebral ischemia reperfusion model by adopting a suture method; s2, experiment grouping: randomly dividing experimental animals into (1) a false operation group: an SHAM group; (2) a cerebral ischemia reperfusion group: an MCAO group; (3) an ear vagus nerve electrical stimulation group after cerebral ischemia reperfusion: a tVNS group; and S3, performing ear vagus nerve electrical stimulation intervention. Ferroptosis related proteins such as GPX4, ACSL4 and FTH1 are detected through Western blot, it is proved that tVNS can improve stroke rat brain tissue ferroptosis, and clear molecular mechanism support is provided for intervention; the content of reduced glutathione and the content of malondialdehyde are respectively detected by using a GSH and MDA content detection kit, and the effectiveness of tVNS in the aspect of relieving ferroptosis is further verified.

There is disclosed a system for providing transcutaneous electrical stimulation to the vagus nerve of an individual comprising: an electrode unit mountable within the auricle of the individual and having at least a first electrode and a second electrode for applying the transcutaneous electrical stimulation at the cymba conchae and the tragus of the individual's auricle, and a controller for controlling the transcutaneous electrical impulse delivered by each of the first electrode and second electrode.

The utility model relates to the field of ear vagus nerve stimulators, and discloses a firmly worn ear vagus nerve stimulator for atrial fibrillation, which comprises a main body, a connecting wire is fixedly arranged on the upper end face of the main body, a wearing module is clamped on the upper end face of the connecting wire, and a connecting module is sleeved on the rear end face of the main body in a threaded manner. The main body comprises a pulse generator, threaded openings are formed in the two sides of the rear end face of the pulse generator, the connecting module comprises a connecting plate, and sliding clamping plates are arranged on the two sides of the connecting plate in a sliding mode. During use, a connecting module is arranged on the rear end face of the main body and provided with a sliding clamping plate, the sliding clamping plate can fix a fixing belt to the rear end face of the main body, the equipment is convenient to carry, the connecting module is provided with a connecting plate, and a first fixing block connected in the connecting plate can be connected with a telescopic rod; damping rotating rods are arranged on the lower end faces of the telescopic rods.

In an illustrative embodiment, methods and system for increasing coagulation potential and / or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.