80 results about "Vagus nerve" patented technology

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

An auricular stimulation device having surface electrodes biased towards each other, and offset from one another, is provided. The stimulation device can be positioned about the ear of a patient with each of the electrodes overlaying auricular ear tissue containing innervation supplied by an auricular branch of the vagus nerve. The electrodes transcutaneously stimulate the auricular branch. Also provided is a method of treating a patient using the auricular stimulation device. The stimulation device can be used for treating patients with conditions such as high blood pressure, depression, high blood glucose level, and tinnitus. Also provided is a diagnostic and therapeutic system having the auricular stimulation device, a smart device and a monitoring device. The smart device controls the auricular stimulation device based on biomarker information received from the monitoring device; and on information related to the patient, such as age, musculoskeletal stability, etc.; and / or on user input.

In an illustrative embodiment, systems and methods for treating stress and / or for improving alertness in a subject using neurostimulation therapy include placing first electrode(s) on, over, or adjacent to an auricular branch of the vagus nerve, placing second electrode(s) on, over or adjacent to an auriculotemporal nerve, and delivering therapeutic stimulation pulses via the first electrode(s) and the second electrode(s) by delivering a first series of stimulation pulses to the first electrode(s), the first series configured to increase activity in neural medullary structure(s), and delivering a second series of stimulation pulses to the second electrode(s), the second series configured to increase activity in neural structures within the Trigeminocervical Complex.

1. Name of the product in this design: Body of a surface electrode. 2. Purpose of this design: The body surface electrode and its main body are used in conjunction with a nerve and muscle stimulator to stimulate the vagus nerve in the ear. 3. The key design features of this product are the shape of the main body of the surface electrode. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Other explanation: The dotted lines in the figure indicate the parts of this design that are not claimed.

The utility model discloses a kind of ear clip type electrodes for stimulating vagus nerve, including first clamping component, second clamping component and elastic piece, first clamping component is hinged with second clamping component, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, one end of elastic piece is clamped in the end of first clamping component away from first electrode end, the other end of elastic piece is clamped in the end of second clamping component away from second electrode end. First clamping component and second clamping component are elastically hinged by elastic piece, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, when ear clip type electrode for stimulating vagus nerve is clamped in user ear, first electrode end and second electrode end accurately contact with user ear, and by using clamping type fixing mode, it is not easy for ear clip type electrode for stimulating vagus nerve to slip, and effectively reduce the foreign body sensation of wearing.

Apparatus for stimulating a cervical vagus nerve including a neck band attachable to a human neck, a therapy module attached to said neck band wherein said neck band positions said therapy module over a cervical vagus nerve, an ultrasound transducer within said therapy module, and a driver circuit configured to excite said ultrasound transducer to apply ultrasonic energy to said cervical vagus nerve. A force-limiting mechanism including a spring-loaded subframe prevents damage to blood vessels adjacent to said cervical vagus nerve. The apparatus operates at low voltages of 5 volts or less suitable for portable battery-powered operation and provides pulsed ultrasonic energy for therapeutic stimulation.

The invention relates to the technical field of medical data processing and intelligent decision-making, in particular to an auxiliary decision-making data processing system for a pediatric hip joint surgery anesthesia scheme, which comprises a multi-dimensional state acquisition module for synchronously acquiring perioperative period physiological signs and environmental event data; the causal decoupling analysis module is used for decomposing the physiological signal fluctuation into nociceptive stimulation, drug inhibition and volume deficiency components; the compensatory reserve evaluation module is used for generating a quantized system compensatory reserve index based on the causal attribution vector; the risk game decision module is used for constructing a multi-target dynamic game model and generating a control strategy according to an interval where an index is located; the proportion optimization output module is used for calculating dynamic proportion parameters aiming at different regulation and control variables and generating a decision instruction; according to the method and the system, latent hemorrhage or vagus nerve reflex can be effectively identified, wrong medication during compensation depletion is avoided, and the safety of a high-risk operation is remarkably improved.

1. The name of the design product: neck stimulator. 2. The use of the design product: stimulator for stimulating the vagus nerve of the neck by ultrasound. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: perspective view 1.

The present application relates to the technical field of bioactive peptides, and in particular to an oat oligopeptide, preparation thereof and application thereof in preparing a product for regulating the expression of brain appetite suppressor factor. The oat oligopeptide can effectively stimulate the release of cholecystokinin (CCK) from intestinal endocrine cells, and stimulate the central nervous system through the vagus nerve pathway, thereby promoting the expression of the appetite suppressor factor pro-opiomelanocortin (POMC) in the hypothalamus. Compared with the prior art, the oat oligopeptide has the advantages of stable structure, high safety, simple preparation process (conventional enzymatic hydrolysis and chromatographic purification can achieve the preparation), easy scale production and the like. The oat oligopeptide is suitable for being used as a functional ingredient or a drug precursor to develop a related health product with the functions of regulating appetite and promoting satiety, and has a wide application prospect in the field of preparing functional products (food, medicine and the like).

The utility model relates to the field of design of medical equipment, in particular to an electrical stimulation device for ear vagus nerves, which comprises a winding part. A winding part is arranged outside the wire, the winding part comprises a wire spool, a wire winding wheel and an adjusting part, the wire spool sleeves the wire, the wire winding wheel is rotatably arranged in the wire spool, an extension part of the wire is wound on the wire winding wheel, the adjusting part is rotatably arranged on one side of the outer part of the wire spool, and the end part of the adjusting part penetrates through the wire spool and is connected with the wire winding wheel. According to the utility model, through the cooperation of the wire spool, the reel, the vortex spring and the adjusting piece, automatic winding and neat storage of wires are realized, and the problem of disorder of the wires is avoided; the ear support and the torsion spring are matched to ensure that the electrode is in close contact with the skin of the ear, so that the electrical stimulation effect is improved.

The application discloses a closed-loop charging regulation system based on a vagus nerve stimulator. The implantable vagus nerve stimulator comprises a motion sensing module for collecting user body motion signals in real time, a temperature sensing module for collecting user temperature signals, an electrocardiogram sensing module for collecting user electrocardiogram signals, and a first communication module for transmitting various signals; a wireless charging positioner performs wireless charging on the implantable vagus nerve stimulator; and an external program-controlled charger comprises a charging management module, which identifies the current conscious state and somatic perception state of the user, generates differentiated charging regulation instructions, and transmits the charging regulation instructions to the wireless charging positioner, so that the wireless charging positioner performs wireless charging on the implantable vagus nerve stimulator according to the charging regulation instructions. The closed-loop charging regulation system based on the vagus nerve stimulator has the advantages of timely responding to discomfort caused by charging, avoiding overcharging, ensuring charging safety, improving charging efficiency and user experience, and the like.

To regulate the number of peripheral regulatory T cells in the intestinal tract and to provide a new means for treating diseases associated with the cells.SOLUTION: A therapeutic agent for a disease, comprising a substance having an effect of regulating the amount of peripheral regulatory T cells in the intestinal tract, wherein the substance is a substance that activates or suppresses the hepatic vagal afferent pathway, a substance that activates or suppresses the left vagal efferent pathway, or an agonist or antagonist of a muscarinic acetylcholine receptor.SELECTED DRAWING: None

The present application relates to a kind of based on motor imagination trigger's electric stimulation synchronous closed loop multimodal neuroregulation system, belong to medical rehabilitation engineering and neural engineering technical field.The system includes: electroencephalogram signal acquisition and processing module, for real-time acquisition user sensory motor cortex electroencephalogram signal, and extract the event-related desynchronization features of motor imagination task in the electroencephalogram signal by time-frequency analysis model;Motor intention recognition and trigger module generates synchronous trigger signal;Functional electric stimulation module, through multi-channel electrode device drive surface electrode output electric stimulation pulse to target area, drive target action;Transcutaneous auricular vagus nerve electric stimulation module, output and motor intention duration synchronous stimulation pulse;Central control and synchronization module, for coordination control timing.Formed " intention recognition-synchronous control-assisted movement" complete closed loop, provides a kind of efficient, accurate, individualized neural engineering solution.

Methods for activating a person's autonomic nervous system may include: electrically coupling a first electrode to a vagus nerve via a transdermal coupling at a location rostral to the human's thoracic spine; electrically coupling a second electrode to a nerve in communication with the same vagus nerve or a different vagus nerve via a transdermal coupling at a site caudal to the human's cervical spine; and applying a therapeutic current waveform to cause current flow between the first and second electrodes and along at least a portion of the vagus nerve or nerves between the first and second electrodes. Apparatuses are disclosed for performing the methods.

The invention discloses an ear clip type ultrasonic vagus nerve regulation and control device and a control method thereof, and belongs to the technical field of biomedical engineering and wearable equipment. The device adopts a shell assembly imitating a TWS earphone, and an ultrasonic transducer, a driving circuit module, an optical auxiliary positioning module, a monitoring module, a control module and the like are highly integrated in the shell assembly. The method is characterized in that a system unlocks ultrasonic stimulation only when an optical positioning result is confirmed to be valid by a user, so that the accuracy of a target spot is ensured; in the stimulation process, automatic safety protection is executed by monitoring the temperature and the contact state in real time. According to the control method, subjective feedback and objective monitoring data of a user are fused, and personalized self-adaptive adjustment of stimulation parameters is achieved. The problems that traditional equipment is heavy, inaccurate in positioning and lack of intelligent safety control are solved, and an accurate, safe and comfortable ultrasonic nerve regulation and control solution capable of being worn daily is provided.

The invention relates to the field of medical equipment, in particular to a nerve stimulator and an output control method thereof, and the nerve stimulator comprises a signal generation unit which is used for outputting an initial signal; the signal output unit is connected with the signal generation unit and used for outputting a stimulation signal according to the initial signal, and the stimulation signal acts on the neck vagus nerve; the frequency range of the stimulation signal is 5 KHz and 20 KHz. The nerve stimulator does not stimulate other nerves, and a better treatment effect is achieved.

The invention relates to the technical field of medicines, in particular to application of a GLP-1 receptor agonist in preparation of a medicine for treating obstructive sleep apnea. The medicine is used for treating obstructive sleep apnea by activating Glp1r < + > neurons in vagus ganglions, the hypopnea index of apnea can be remarkably reduced, the longest apnea duration is shortened, and a new treatment approach is provided for treating obstructive sleep apnea.

The application discloses a pre-meal nerve electric stimulation control method, device and system. The method comprises the following steps: detecting whether a pre-meal intervention condition is met; when the pre-meal intervention condition is met, generating a biphasic pulse electric stimulation by calling preset output parameters, wherein the preset output parameters comprise a constant stimulation frequency, a constant stimulation pulse width and a stimulation current; and controlling an electrode sheet to output the biphasic pulse electric stimulation to a target vagus nerve site. By outputting the biphasic pulse electric stimulation to the target vagus nerve site when the pre-meal intervention condition is met, the target vagus nerve can be quickly activated before a meal, the body is prepared for adjusting insulin secretion in advance, the postprandial blood glucose peak value can be more effectively flattened, the intervention effect is improved, and thus standard weight management is realized.

The invention discloses an ear vagus nerve acoustoelectric dual stimulation system and method, and relates to the technical field of nerve stimulation medical treatment. The objective of the invention is to solve the technical problems of limited autonomic nerve regulation effect, insufficient cardiovascular disease prevention and treatment efficiency, easy generation of nerve adaptation due to long-term stimulation, poor regulation and control precision and the like in the existing ear vagus nerve single electrical stimulation mode. The system comprises an electrical stimulation module, a sound stimulation module, a control module, an electrode, a sound stimulation probe, a power supply module and a parameter input module, the control module cooperatively regulates and controls all the modules, and the electrodes and the sound stimulation probe output electrical stimulation and sound stimulation respectively. According to the method, acoustic-electric dual synergistic stimulation of the ear vagus nerves is realized by cooperatively regulating and controlling stimulation parameters. The acousto-electric synergistic interaction is utilized, the autonomic nerve regulation and control ability is enhanced, the physiological index regulation precision is improved, related cardiovascular diseases are effectively prevented and treated, the advantages of being high in safety, wide in adaptability, stable in regulation, convenient and fast to operate and capable of being used for a long time are achieved, and the method can be applied to clinical prevention and treatment, rehabilitation treatment and family health management scenes.

In an illustrative embodiment, systems and methods for treating stress and / or for improving alertness in a subject using neurostimulation therapy include placing first electrode(s) on, over, or adjacent to an auricular branch of the vagus nerve, placing second electrode(s) on, over or adjacent to an auriculotemporal nerve, and delivering therapeutic stimulation pulses via the first electrode(s) and the second electrode(s) by delivering a first series of stimulation pulses to the first electrode(s), the first series configured to increase activity in neural medullary structure(s), and delivering a second series of stimulation pulses to the second electrode(s), the second series configured to increase activity in neural structures within the Trigeminocervical Complex.

Methods and uses of compositions (e.g. comprising one or more microbial strains, one or more components, one or more metabolites, or any combination thereof) for prevention, reduction of risk, treatment, and / or improvement of Vagus Nerve associated diseases, disorders, and conditions (e.g. including Vagus nerve and its components (e.g. Vagus nerve system components), including any diseases of organs that are connected to the Vagus Nerve, etc.) are disclosed.

The invention is a non-implantable device electro stimulator Vagus nerve synchronized by thoracic movements in humans to improve the body motor function of patients after suffering an ischemic stroke, consisting of an atrial mechanism with four Electrodes that stimulate the nerve branches located in an earpiece that electrically stimulate the endings of the Vagus nerve that are located in the area of the Cavum Conchae and the Cymba Conchae of the left ear and the right ear and which in turn connects wirelessly to a mobile application that configures the stimulation parameters, also has a breathing cycle sensing band to sense the breathing placed around the user's chest that measures the expansion and recoil of the chest during breathing.

According to the animal airway response induction real-time detection system and detection method provided by the invention, the photogenetic stimulation unit irradiates the photosensitive protein of the experimental subject by using the light source with the preset wavelength, and performs photostimulation on neurons in a specific brain region of the experimental subject; receiving an airway hyperresponse signal generated by the experimental subject after receiving the photostimulation in real time through a signal acquisition unit, and acquiring lung function data of the experimental subject; the collected data is subjected to fitting calculation through the processing unit, the lung function and capacity indexes are obtained, real-time detection of animal airway hyperresponse is achieved, activation of vagus nerves is allowed to be accurately controlled in time and space by adopting the photogenetic technology, real-time detection of animal airway response is achieved, and the accuracy of animal airway hyperresponse detection is improved. The accuracy and the reliability of an experiment result are improved; the repeatability of an experimental result is ensured by standardizing an experimental process and setting light source parameters; a local minimally invasive invasive photostimulation mode reduces trauma and stress response to an experimental subject.

A method and apparatus for treatment of hypertension and heart failure by increasing vagal tone and secretion of endogenous atrial hormones by excitory pacing of the heart atria. Atrial pacing is done during the ventricular refractory period resulting in atrial contraction against closed AV valves, and atrial contraction rate that is higher than the ventricular contraction rate. Pacing results in the increased atrial wall stress. An implantable device is used to monitor ECG and pace the atria in a nonphysiologic manner.

The utility model relates to the technical field of medical instruments, in particular to an ear and neck percutaneous stimulation device for the vagus nerve of a human body. The utility model provides an ear and neck percutaneous stimulation device for human vagus nerves, which comprises a mounting sleeve and the like, the mounting sleeve is slidably connected with a pair of neck stimulators, the mounting sleeve is fixedly connected with a pair of ear stimulators through wires, the neck stimulators are fixedly connected with a fixing sleeve, the fixing sleeve is slidably connected with the mounting sleeve, the fixing sleeve is slidably connected with a clamping block, and the clamping block is fixedly connected with the neck stimulators through wires. A spring is fixedly connected between the clamping block and the fixing sleeve, the mounting sleeve is fixedly connected with a limiting plate, the clamping block is in extrusion fit with the limiting plate, and an attaching assembly is arranged on the mounting sleeve. The ear and neck percutaneous stimulation device for the vagus nerve of the human body can be adaptively adjusted according to the shape and the size of the neck of the patient through the fixing sleeve, the limiting plate and other parts, so that it is ensured that the neck stimulator can stimulate the proper position of the neck of the patient, the percutaneous stimulation effect is ensured, and the universality of the ear and neck percutaneous stimulation device for the vagus nerve of the human body is improved.

An apparatus (100) for treating reflux disease in a human patient, the apparatus comprising an implantable movement restriction device (110) shaped and sized for placement against a fundus wall portion (14) of the patient's stomach (10), the movement restriction device being positioned for implantation between the patient's pleural diaphragm (30) and a portion of the gastric fundus wall, and configured to restrict movement of the patient's lower esophageal sphincter (26) of the stomach toward the thoracic diaphragm to prevent the lower esophageal sphincter from slipping through an opening (32) in the thoracic diaphragm and into the patient's thoracic cavity. A first electrode arrangement is configured to contact and electrically stimulate the lower esophageal sphincter (26) to cause contraction thereof, and an inhibitory electrode arrangement (150') is configured to transmit an electrical inhibitory signal to the vagus nerve.

An electrode array for peripheral nerve stimulation, in particular for auricular punctual stimulation of the vagus nerve, including a planar carrier and a plurality of needle-shaped electrodes protruding from the carrier and at least one electrical terminal, which is electrically conductively connected to the electrodes or to a subgroup of electrodes, for electrical connection to a stimulation device, the electrodes having a maximum length of 0.6 mm, preferably 0.4 mm

The application discloses a bilateral transaural vagus nerve regulation device, an electronic device and a storage medium. The nerve regulation device comprises an auditory stimulation module configured to apply multiple novel stimuli to a target object within an auditory stimulation period; a processing module configured to obtain an electroencephalogram signal corresponding to each electroencephalogram channel when each novel stimulus is applied to the target object; determine a target frequency when fitting the electroencephalogram signal with a target lag order based on the electroencephalogram signal corresponding to each electroencephalogram channel; determine a first proportion based on the information exchange intensity between different brain regions of the target object at each time point and the target frequency; determine a second stimulation frequency within a next electrical stimulation period adjacent to the auditory stimulation period based on the first proportion, the first stimulation frequency and the target frequency; and an electrical stimulation module configured to electrically stimulate the auricular vagus nerve of the binaural of the target object at the second stimulation frequency within the next electrical stimulation period.

This disclosure relates to a method, device, and system used for identifying and treating responders to external nerve stimulation via a combination of a skin electrode assembly and a functional near-infrared spectroscopy (fNIRS) device. More specifically, this specification discloses a method for cutaneous stimulation of the trigeminal nerve, occipital nerve, vagus nerve, facial nerve and / or any of their branches, and a method for measuring cerebral blood flow in a target brain region.