172 results about "Vagus nerve" patented technology

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

The invention discloses a cranial nerve double-path stimulation intelligent regulation and control method and system for Parkinson's disease, and relates to the technical field of medical treatment and neural engineering, and the method comprises the steps: obtaining an electroneurographic signal of a target patient based on a stimulation electrode, and determining neural activity features according to the electroneurographic signal; the stimulating electrodes comprise a first stimulating electrode and a second stimulating electrode; determining a nerve evaluation value according to the nerve activity characteristics, and generating a co-stimulation parameter based on the nerve evaluation value; initial stimulation parameters of the stimulation electrode are adjusted based on the co-stimulation parameters, the target patient is stimulated through the stimulation electrode, and cranial nerve two-way stimulation intelligent regulation and control for the Parkinson's disease are completed. According to the invention, by introducing the abnormal oscillation mode and evaluating the synchronism characteristics of the neural network in real time, the neural activities of the deep brain and the vagus nerve area are comprehensively quantified, and the accuracy of nerve regulation and control is improved; by generating collaborative stimulation parameters and comprehensively considering the mutual influence of the two stimulation pathways, intelligent collaborative regulation and control are realized.

A system for treating chronic inflammation may include an implantable microstimulator, a wearable charger, and optionally an external controller. The implantable microstimulator may be implemented as a leadless neurostimulator implantable in communication with a cervical region of a vagus nerve. The microstimulator can address several types of stimulation including regular dose delivery. The wearable charger may be worn around the subject's neck to rapidly (<10 minutes per week) charge an implanted microstimulator. The external controller may be configured as a prescription pad that controls the dosing and activity of the microstimulator.

Methods and systems for stimulation of the vagus nerve of a patient using a stimulation system is described herein. The stimulation system including a control module and at least one stimulation lead coupleable to the control module, the at least one stimulation lead including a plurality of electrodes. The method includes implanting the at least one stimulation lead percutaneously or through an opening in the carotid sheath with placement of the electrodes proximate to the vagus nerve for stimulation of the vagus nerve; implanting the control module remote from the vagus nerve; generating stimulation signals using the control module; and delivering the stimulation signals from the control module through at least one of the electrodes of the at least one stimulation lead to stimulate the vagus nerve of the patient.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The invention provides a nerve electrical stimulation method, device and system based on electroencephalogram signals, and the method comprises the steps: obtaining pain related features in real time, the pain related features comprising electroencephalogram index features and heart rate variability features; generating a comprehensive pain score value in real time based on the pain related characteristics, and generating an electrical stimulation parameter in real time based on a target difference value between the comprehensive pain score value and the baseline score value; the vagus nerve of the patient is electrically stimulated based on the electrical stimulation parameters. The problem that in the prior art, due to immobilization of electrical stimulation parameters, dynamic adjustment cannot be conducted according to real-time neural activity of a patient, and therefore the treatment effect is affected is solved.

Method for reversing demyelination in a patient having a demyelinating disorder may include detecting one or more biomarkers for demyelination from the patient, receiving, in an implanted vagus nerve stimulator, a command to apply a remyelinating stimulation to the patient based on a level of the detected one or more biomarkers for demyelination; and applying electrical stimulation to the patient's vagus nerve from the implanted vagus nerve stimulator to reverse demyelination and increase remyelination of the patient's nerves. The electrical stimulation may be adjusted based on the level of the detected one or more biomarkers.

The utility model relates to the technical field of medical equipment, discloses a non-invasive ear vagus nerve stimulator, and solves the problems that a stimulator and a stimulating electrode of a conventional ear vagus nerve stimulator need to prop open an auricular concha area, so that a patient is prone to generating ear pressing pain, and subsequent normal treatment is affected. Through the elastic force of the C-shaped elastic column, clamping force is generated between the stimulator body and the flexible clamping block which are connected with the C-shaped elastic column, the stimulator body and the flexible clamping block are clamped on the front face and the back face of the ear respectively, the stimulator body is fixed to the position of the auricular conchae, a discharging head on the electrode mechanism can be attached to the auricular conchae conveniently, and the electrode column is elastically supported through the rubber column. According to the ear protection device for the auricular conchae, the rubber columns elastically support the electrode columns, so that when the ear protection device is used for coping with the ears of different patients, the rubber columns can adaptively deform, and the discharge heads on the surfaces of the electrode columns can be better attached to the auricular conchae.

Devices and methods for the non-invasive stimulation of nerves, such as the vagus nerve, include a housing and an electrode coupled to the housing. The electrode is configured to be positioned adjacent to, or in contact with, an outer skin surface of a patient. A source of energy is coupled to the housing and operably coupled to the electrode. The source of energy emits an electrical impulse to the electrode such that the electrical impulse passes through the outer skin surface of the patient to a nerve at a target region in the patient sufficient to modulate the nerve. The electrical impulse comprises burst periods and constant periods, wherein each burst period includes 2 to 20 pulses and has a duration of less than 20,000 microseconds.

Embodiments treat inflammation of a user by applying a first patch on a dermis of the user adjacent to an afferent nerve, the first patch comprising first electrodes, and applying a second patch on the dermis of the user adjacent to a vagus nerve or a vagus nerve connecting branch, the second patch comprising second electrodes. Embodiments generate a treatment protocol during a time period comprising simultaneously applying a first electrical stimuli to the afferent nerve via the first electrodes of the first patch and applying a second electrical stimuli to the vagus nerve or the vagus nerve connecting branch via the second electrodes of the second patch.

Disclosed herein is a noninvasive auricular neurostimulator comprising a stimulation device for activating an auricular branch of the Vagus nerve, said stimulation device comprising an active electrode facing a concha cavum of the ear, and a return electrode facing an Eminence of the concha, or the retro auricular sulcus.

A bilateral auricular nerve stimulation system of the vagus nerve, which comprises two adjustable stimulator devices (4) in each ear respectively where each one comprises a support piece (5) with a curved temple (6); three or more cathodal stimulation electrodes simultaneously, with a first and second electrode (1, 2) that fit into the cymba and cavum respectively and a third electrode (3) that fits into the external auditory canal (EAC), where all electrodes are connected to one or more anodes (32), and have means of adjustment to their area of action; a photoplethysmography biosensor (PPG) (7) located at the free end of the curved temple (6), and; control means inside the support piece (5); where the system comprises a connection and synchronization cable between both stimulator devices.

In an illustrative embodiment, an apparatus for controlling or reducing stress levels includes an ear-mounted device having an earpiece for positioning over a wearer's ear contacting tissue regions surrounding the ear, and electrodes for delivering non-piercing neurostimulation, with first electrode(s) arranged on a first surface of the earpiece to contact a first tissue region, and second electrode(s) are arranged on a second surface to contact a second tissue region. The auricular branch of the vagus nerve or the auriculotemporal nerve is situated beneath the first tissue region. The apparatus includes a controller to deliver therapeutic stimulation pulses via the stimulation device, where the pulses in combination with the positioning of the first electrode(s) and the second electrode(s) are configured to modulate the activity ratio between the sympathetic nervous system and the parasympathetic nervous system, thereby increasing vagal tone.

In an illustrative embodiment, methods and system for increasing coagulation potential and / or triggering a higher platelet activation rate in a subject via auricular neurostimulation include contacting skin of the subject with one or more therapeutic electrodes, each electrode positioned in a respective region of nerve structures of the auriculotemporal nerve (ATN), nerve structures connected to the ATN, nerve structures of the auricular branch of the vagus nerve (ABVN), or nerve structures connected to the ABVN, applying, to the electrodes, one or more stimulation patterns.

The invention relates to a left basal joint cerebral hemorrhage rat ear vagus nerve electrical stimulation fMRI brain region activation map construction method and an activation brain map. The method comprises the steps of adaptation, grouping, modeling, intervention and evaluation of rats; the brain of the rat is scanned, and image data are collected; carrying out data processing, statistics and analysis on the acquired image data based on an SPM12 algorithm architecture; based on the mixed effect model, analyzing the effectiveness of longitudinal remodeling and VNS regulation of spontaneous brain activity in the brain region of the rat, and establishing a VNS brain activity map database; and based on the mixed effect model, analyzing the effectiveness of longitudinal remodeling and VNS regulation of the core nodes in the rat brain region, and establishing a VNS brain core node database. According to the present invention, the current rat brain function change condition is detected, the VNS stimulation brain region activation map is established according to the active state of the current brain region of interest, the comparison reference data is provided for the VNS regulation brain function experiment, and the reference is provided for the experiment process of the optimization of other rat brain function pathological models.

The invention discloses a sympathetic cervical spondylosis autonomic nerve regulation enhancing method based on a brain-computer interface, and relates to the technical field of nerve regulation and repair. According to the method, by synchronously collecting electroencephalogram and skin conductance signals and conducting time-frequency domain conjoint analysis and Lempel-Ziv complexity evaluation, accurate quantitative evaluation on sympathetic nerve activity and nerve disorder degree is achieved, double-model collaborative decision-making of machine learning and deep reinforcement learning is utilized, personalized nerve regulation parameters are intelligently generated, and the method has the advantages of being high in accuracy and high in accuracy. High-targeting and safe intervention is implemented through double-target hierarchical regulation and control aiming at neck sympathetic nerves and vagus nerves, and stimulation parameters are dynamically optimized in a closed-loop manner by adopting a genetic algorithm on the basis of real-time feedback of heart rate variability, skin conductance and autonomic nerve balance indexes, so that the stimulation accuracy is improved. Therefore, the sympathetic cervical spondylosis autonomic nerve regulation efficiency and effect are enhanced.

Methods and devices are provided for the non-invasive treatment of diseases or disorders, such as Alzheimer's disease, Parkinson's disease, rheumatoid arthritis (RA), multiple sclerosis, postoperative cognitive dysfunction, or postoperative delirium. A device comprises a stimulator having an electrode configured for contacting an outer skin surface of a neck of the patient and an energy source configured to transmit, via the electrode, an electric current transcutaneously and non-invasively through the outer skin surface of the neck of the patient to generate an electrical impulse at or near a vagus nerve within the patient. The electrical impulse comprises bursts of 2 to 20 pulses with each of the bursts comprising a frequency from about 15 Hz to about 50 Hz and with each of the pulses comprising a duration from about 20 microseconds to about 1000 microseconds.

The invention belongs to the technical field of diagnostic data processing, and particularly relates to a percutaneous ear vagus nerve electrical stimulation and disturbance of consciousness correlation qualitative analysis method and system. The consciousness state of the patient can be reflected more comprehensively by constructing the feature information of the standard consciousness evaluation index data distribution data, in addition, influence factors of drug therapy and diseases and lesions can be identified and eliminated more accurately through corresponding verification of the electrical stimulation signal abnormal fluctuation value, and the accuracy of the diagnosis result is improved. Therefore, the accuracy and effectiveness of pathogenesis analysis of the patient are improved, and medical resources can be reasonably distributed and used; the invention further provides a percutaneous ear vagus nerve electrical stimulation and disturbance of consciousness correlation qualitative analysis system and electronic equipment.

Disclosed are apparatuses and methods for reducing or limiting blood loss and reducing bleed time in a subject by combined vagus and trigeminal stimulation. The apparatuses and methods may activate (e.g., electrically) one or more branches of the trigeminal nerve and may concurrently (at overlapping or near-overlapping time) independently activate the vagus nerve. This activation may be invasive or non-invasive.

The present disclosure relates to methods, devices and systems used for the identification and treatment of responders to external nerve stimulation via a combination of a cutaneous electrode assembly and a functional near-infrared spectroscopy (fNIRS) device. More specifically, cutaneous methods of stimulation of the trigeminal nerve, the occipital nerve, the vagus nerve, the facial nerve, and / or any branch thereof and measurement of cerebral blood flow at targeted brain areas are disclosed herein.

The invention, which belongs to the technical field of the medical equipment, discloses a wake-up therapy system for frequency response through auricular vagus nerve magnetoelectricity stimulation, and the system comprises an acquisition conversion module, an anomaly detection module, a spatial modeling module, an anomaly analysis module, a stimulation application module, a monitoring adjustment module, a dynamic adjustment module and an interactive display module. According to the method, accurate analysis from electroencephalogram signals to the space level can be achieved, quantitative evaluation and visual presentation of abnormal brain functions of the patient are achieved, doctors are assisted in judging the brain function state of the patient, and scientific and accurate decision support is provided for awakening therapy of coma or brain injury patients; meanwhile, the therapeutic effect can be evaluated, stimulation parameters can be dynamically adjusted, individualized awakening intervention of the patient is promoted, the nerve over-stimulation risk of the patient is reduced, the abnormal brain area of the patient is accurately positioned, and a basis is provided for precise stimulation.

The invention belongs to the field of medical instruments, and particularly discloses a magnetic control vibration capsule capable of being adsorbed for a long time and a system. The magnetic control component responds to polarity change of an external magnetic field, multiple times of starting and stopping of the vibration motor are achieved, the annular magnet magnetized in the radial direction responds to existence of the external magnetic field, the vibration capsule is attracted to the designated position in the digestive tract for a long time, attraction and vibration control are achieved at the same time through the external magnetic field, and the vibration effect is improved. The capsule can be retained for a long time, triggered for multiple times and stimulated to the gastric vagus nerve for multiple times, so that the purposes of repeatedly using the weight-losing vibration capsule and reducing the times of swallowing the capsule are achieved. The whole circuit is triggered by depending on a mechanical structure, an external magnetic field can be used for controlling the on-off of the circuit, the circuit can be closed when not used, and the theoretical endurance time is not less than 10 hours.

An auricular stimulation device having surface electrodes biased towards each other, and offset from one another, is provided. The stimulation device can be positioned about the ear of a patient with each of the electrodes overlaying auricular ear tissue containing innervation supplied by an auricular branch of the vagus nerve. The electrodes transcutaneously stimulate the auricular branch. Also provided is a method of treating a patient using the auricular stimulation device. The stimulation device can be used for treating patients with conditions such as high blood pressure, depression, high blood glucose level, and tinnitus. Also provided is a diagnostic and therapeutic system having the auricular stimulation device, a smart device and a monitoring device. The smart device controls the auricular stimulation device based on biomarker information received from the monitoring device; and on information related to the patient, such as age, musculoskeletal stability, etc.; and / or on user input.

The utility model relates to an electrical sheet subassembly and nerve electrical stimulation device, including electrical sheet, conducting wire, sheath tube and gasbag, the distal end of conducting wire is connected with the proximal end of electrical sheet, sheath tube and gasbag all sleeve the outside of conducting wire, the distal end of sheath tube is connected with the proximal end of gasbag, and the distal end of sheath tube is connected with the proximal end of gasbag. The far end of the air bag is connected with the near end of the electric sheet, an air channel is formed between the sheath tube and the wire, and the air channel is communicated with the air bag. The electric sheet is implanted into the vagus nerve in a mode of guiding a puncture needle through ultrasound, and an open operation is not needed to dissect the free vagus nerve, so that the trauma of a patient is reduced, a general anesthesia operation and a relatively large operative incision are avoided, rapid later rehabilitation is facilitated, and the opportunity of vagus nerve electrical stimulation treatment is provided for the patient who cannot bear the general anesthesia operation.

The invention discloses a vagus nerve electrical stimulation regulation method capable of relieving ARDS lung injury, and relates to the technical field of ARDS lung injury. In order to improve the therapeutic effect and prognosis of ARDS patients; comprising the following steps that 1, an ARDS animal model is established, and the animal model is constructed by instilling lipopolysaccharide (LPS) into the trachea; 2, after the ARDS model is established, separating and exposing the left vagus nerve of the animal; and 3, performing electrical stimulation on the left vagus nerve by using an electrical stimulation device, wherein the stimulation parameters comprise the voltage of 5V, the frequency of 5Hz and the pulse width of 2ms, and the stimulation lasts for 10 minutes. By implementing a vagus nerve electrical stimulation (VNS) regulation method, lung tissue pathological changes of an ARDS rat model can be remarkably improved, such as alveolar wall thickening, alveolar cavity stenosis and inflammatory cell infiltration, the lung injury score and the lung moisture-to-dry ratio are remarkably reduced, and the pulmonary edema condition is effectively relieved.

In an illustrative embodiment, systems and methods for treating stress and / or for improving alertness in a subject using neurostimulation therapy include placing first electrode(s) on, over, or adjacent to an auricular branch of the vagus nerve, placing second electrode(s) on, over or adjacent to an auriculotemporal nerve, and delivering therapeutic stimulation pulses via the first electrode(s) and the second electrode(s) by delivering a first series of stimulation pulses to the first electrode(s), the first series configured to increase activity in neural medullary structure(s), and delivering a second series of stimulation pulses to the second electrode(s), the second series configured to increase activity in neural structures within the Trigeminocervical Complex.

1. Name of the product in this design: Body of a surface electrode. 2. Purpose of this design: The body surface electrode and its main body are used in conjunction with a nerve and muscle stimulator to stimulate the vagus nerve in the ear. 3. The key design features of this product are the shape of the main body of the surface electrode. 4. The picture or photo that best illustrates the key design points: Design 1 3D diagram 1. 5. Design 1 is designated as the basic design. 6. Other situations requiring explanation: Other explanation: The dotted lines in the figure indicate the parts of this design that are not claimed.

The utility model discloses a kind of ear clip type electrodes for stimulating vagus nerve, including first clamping component, second clamping component and elastic piece, first clamping component is hinged with second clamping component, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, one end of elastic piece is clamped in the end of first clamping component away from first electrode end, the other end of elastic piece is clamped in the end of second clamping component away from second electrode end. First clamping component and second clamping component are elastically hinged by elastic piece, one end of first clamping component forms first electrode end, one end of second clamping component forms second electrode end, when ear clip type electrode for stimulating vagus nerve is clamped in user ear, first electrode end and second electrode end accurately contact with user ear, and by using clamping type fixing mode, it is not easy for ear clip type electrode for stimulating vagus nerve to slip, and effectively reduce the foreign body sensation of wearing.

Various methods and apparatus for treating a condition associated with impaired glucose regulation in a subject comprising in one embodiment, applying a neural conduction block to a target nerve at a blocking site with the neural conduction block selected to at least partially block nerve pulses. In another embodiment, combinations of down-regulating and or up-regulating with are used to treat impaired glucose regulation. In other embodiments, up-regulation or down-regulation of various nerves, such as the vagus and its branches, are used to modify the secretion of insulin and glucagon from the pancreas, thereby controlling glucose levels. In yet further embodiments, combinations of down-regulating and or up-regulating are used to control sensitivity of the liver to plasma insulin and glucagon to treat impaired glucose regulation.