181 results about "Neurostimulation" patented technology

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

The present disclosure provides systems and methods for providing neurostimulation therapy according to gait features. The gait features may be analyzed to develop a patient model between gait features and optimal settings for a neurostimulation therapy using machine learning operations. The model is used to control ongoing neurostimulation therapy for the patient.

The application provides a wireless and battery-free brain nerve stimulator and a preparation method. The brain nerve stimulator can be driven by a mobile phone loudspeaker, and a resonator designed can effectively amplify a piezoelectric signal. The brain nerve stimulator comprises two parts: a base provided with implantable nerve stimulation electrodes and a resonant cavity device connected through magnetic coupling. The design scheme of the brain nerve stimulator provides a general method for inhibiting epilepsy. The brain nerve stimulator can be extended to target brain deep layers or surface areas and peripheral nervous systems. A stimulation mode can be wirelessly transmitted and controlled. It is proved by electroencephalogram recording of free-moving mice that the wireless nerve stimulator can effectively relieve seizure events of the epileptic mice in vivo.

This invention discloses a neurostimulation system, comprising: a stimulator and a lead wire; the stimulator includes: a connection channel and a control module; the lead wire includes: an implantation end inserted into a target point and a connection end inserted into the connection channel; the connection end is provided with an identification circuit consisting of a positioning ring and multiple coding rings; the type of the lead wire corresponds to the shorting method between the positioning ring and the coding rings; the connection channel is provided with a cooperating circuit connected to the identification circuit; wherein, the control module is connected to the cooperating circuit and configured to: when the connection end of the lead wire is inserted into the connection channel, read the address bit combination of the identification circuit; and determine the lead wire type according to the address bit combination and a pre-stored address bit combination library corresponding to the lead wire type. The technical solution of this invention improves configuration efficiency and accuracy by forming an address code through shorting the positioning ring and the coding ring, allowing the stimulator to read and match the pre-stored library.

The present application relates to the technical field of neuromodulation, and discloses a neuromodulation system and method for dual-task gated taVNS. The present application collects kinematic data and cognitive performance data of a patient performing a motor-cognitive dual task; obtains an objective maximum load paradigm according to the kinematic data and the cognitive performance data, obtains a subjective maximum load paradigm according to a subjective work load score, and combines the two to obtain a maximum intensity dual-task load paradigm; applies multiple trial dual-task training to the patient under the maximum intensity dual-task load paradigm, and in each trial, determines in real time whether to trigger transcutaneous auricular vagus nerve stimulation according to a dual-dimension gating condition, triggers to generate a stimulation signal when the cognitive correctness condition and the motor safety condition are both satisfied, and suspends the presentation of a new task during the stimulation duration. The present application realizes precise coupling of dual-task training and neuromodulation in the time dimension, and improves the timing specificity and individualization of neuromodulation.

Embodiments described herein relate to systems, devices, and methods for monitoring brain activity and delivering electrical brain stimulation to a patient. In some embodiments, a system can deliver responsive electrical stimulation in a closed-loop manner and can offer real-time or near real-time monitoring of induced neurophysiological effects. After detecting a targeted brain pattern (i.e., an epileptic seizure), the system may deliver high-intensity ultra-short electrical stimulation impulses non-invasively or minimal-invasively to diminish or stop the neural oscillations underlying the epileptic seizure. The stimuli are delivered in time and space, relative to the emerging seizure rhythm patterns, such that they diminish or terminate the seizure. The system may include an implantable device including one or more electrodes electrically coupled to one or more processors. The processor(s) may be operatively coupled to a memory, one or more communication modules, and may optionally be coupled to a battery and one or more additional sensor(s).

Disclosed herein is a neurostimulation system comprising: a stimulation device comprising a stimulator configured to provide electrical stimulation to one or more branches of a nerve of a user or one or more muscles of the user; a memory storing machine readable instructions; and a control system including one or more processors configured to execute the machine-readable instructions to implement an adaptive process. The adaptation procedure is configured to adapt the user to a neurostimulation treatment for assisting the user in breathing prior to the start of a treatment session by setting a stimulation pattern of the system to a starting stimulation pattern, the initial stimulation pattern is configured such that a level of electrical stimulation applied in the initial stimulation pattern is weaker than a level required to provide the neurostimulation therapy; causing the stimulation device to provide the electrical stimulation to the one or more branches or the one or more muscles of the nerve in the initial stimulation mode; receiving response data from the user or obtained by measuring a physiological output of the user; processing the response data to determine a stimulus response; altering the stimulation pattern to increase the level of electrical stimulation applied in the pattern when the stimulation response is within a tolerable threshold range; and stopping stimulation when the stimulation response is not within the tolerable threshold range or the stimulation pattern is at a predefined limit.

A system for providing neurostimulation to a patient includes a pulse generator having a housing. The implantable neurostimulation lead is configured to connect with a pulse generator, and the pulse generator is configured to generate a plurality of electrical pulses for delivering neurostimulation therapy through the lead to a patient when the lead is implanted at a target location. The lead includes one or more conductors extending from a proximal end of the lead to one or more neurostimulation electrodes disposed at or near a distal end of the lead. The lead comprises an energy absorber comprising a carbon nanotube material and extending substantially along the length of the one or more conductors.

An example method includes delivering one or more electrical stimulation signals to a patient, sensing a composite stimulation-evoked signal comprising a composite of signals generated by one or more signal sources in response to the one or more electrical stimulation signals, and controlling delivery of electrical stimulation therapy to the patient based on the composite stimulation-evoked signal.

A method of controlling a neural stimulus, the neural stimulus being defined by at least one stimulus intensity parameter. The method comprises, generating a stimulus intensity parameter to control a stimulator that generates a stimulus current for application to a tissue, measuring a response of the tissue, evoked by the stimulus current, determining a response parameter indicative of the measured response, in response to the response parameter being less than a first threshold, setting the stimulus intensity parameter to a desired stimulus intensity level; and in response to the response parameter being greater than a second threshold, adjust the stimulus intensity parameter according to a feedback variable derived from the measured response.

The method includes receiving one or more attributes of a patient and receiving a plurality of audio contents from a data source associated with the patient. Predictions of amplitudes of brain response signals at target frequencies and affinity scores are generated for at least some of the plurality of audio contents. First audio content is selected from the plurality of audio contents based on the predictions of amplitudes and affinity scores for the first audio content. A control signal is transmitted to an output device, causing the output device to render the first audio content and provide the audio stimulus to the patient.

This disclosure provides a system for preparing a patient for examination in a medical magnetic resonance imaging (MRI) environment. The system includes: a magnetic resonance imaging unit (20) applied to the MRI environment and including at least one magnetic coil controlled to provide magnetic stimulation to intentionally stimulate nerves and / or muscles of a peripheral body part of the patient during the examination phase; and a first device (10) applied during a patient preparation phase prior to the examination phase; wherein the MRI unit (20) and the first device (10) are configured to provide tactile communication with the patient by intentionally stimulating nerves and / or muscles of a peripheral body part of the patient, wherein the first device (10) includes: at least one stimulation unit (11) adapted to act as a proxy for the MRI unit (20) by simulating subsequent magnetic stimulation from the MRI unit (20) as proxy electrical stimulation and / or proxy magnetic stimulation, and to operate separately from the magnetic stimulation from the MRI unit, and by applying stimulation by a means different from the magnetic stimulation from the MRI unit. The system includes an electrical stimulation and / or magnetic stimulation to intentionally stimulate nerves and / or muscles in the peripheral body parts of the patient; and at least one data processing unit (12) adapted to control the at least one stimulation unit (11) to apply the electrical stimulation and / or the magnetic stimulation, wherein at least one patient stimulation threshold is assigned to the proxy electrical stimulation and / or the proxy magnetic stimulation, and the at least one data processing unit (12) is also adapted to correlate the at least one patient stimulation threshold associated with the proxy electrical stimulation and / or the proxy magnetic stimulation with a corresponding threshold assigned to the magnetic stimulation used in the medical magnetic resonance imaging environment, and to provide control parameters for applying the subsequent magnetic stimulation by the magnetic resonance imaging unit (20) based on the correlation; wherein the at least one data processing unit (12) is also adapted to provide tactile interaction information data and / or tactile interaction instruction data associated with the proxy intentional stimulation via a user interface to train the patient for tactile communication during a subsequent examination phase.

This invention provides a control device and system for a neurostimulator. The device includes: an operation instruction generation unit configured to acquire operations performed by a target object and generate corresponding operation signals based on the operations; a control unit configured to generate corresponding internal control commands or external stimulation state control commands based on the type of the operation signals and the operating state of the control device, and send the stimulation state control commands to the neurostimulator so that the neurostimulator can parse the operation type in the stimulation state control commands and adjust the stimulation output state in conjunction with the current stimulation output state; the control unit is further configured to acquire stimulation state control command response information fed back by the neurostimulator, the stimulation state control command response information including the adjusted stimulation output state. By implementing this invention, the state switching of the pulse output state of the neurostimulator can be realized through a single operation instruction generation unit, allowing users and patients to perform various operations on the control device by only learning a few simple operations, which is convenient and quick.

In one aspect, the present disclosure is directed to an implantable medical device including a housing having a generally planar portion, and a piezoelectric transducer disposed within the housing, wherein at least a portion of the piezoelectric transducer is arranged at an oblique angle to the generally planar portion of the housing, and an electrode to deliver a neurostimulation therapy. The implantable medical device is configured to receive energy signals from an external device and transduce the received energy signals into electrical power.

2.1 A medical device comprising an invasive component with at least one electrode designed for positioning on a nerve and for emitting an electrical stimulation signal, and a signal generator connected to the electrode and designed to generate the stimulation signal, wherein the stimulation signal is designed to inhibit nerve excitation transmission, is known. 2.2 According to the invention, the at least one electrode is configured to emit an electrical control signal and the signal generator is configured to generate the control signal, wherein the control signal is configured to trigger a motor and / or sensory reaction, the expression of which depends on a distance between the electrode and the nerve. 2.3 Use in pain therapy using neurostimulation

The invention belongs to the technical field of biomedical signal processing and nerve regulation and control, and discloses a closed-loop time interference nerve regulation and control system and method based on synchronous electroencephalogram signals. The closed-loop nerve regulation and control system integrates multi-channel electroencephalogram collection, neural state real-time recognition, brain network function connection analysis, traceability positioning calculation and individualized time interference stimulation strategies, an upper computer module can obtain electroencephalogram signals and analyze brain function states in real time, abnormal network structures are automatically recognized, and the brain function states are analyzed in real time. A double-target stimulation path is formulated by combining a nerve source positioning result, so that the defects of inaccurate positioning, incapability of responding to brain state change in real time and unpredictable stimulation effect of a traditional nerve stimulation method are overcome; the closed-loop mechanism of'perception-decision-execution-evaluation 'of the system not only enhances the effectiveness of stimulation, but also remarkably improves the safety, controllability and individualization level of the regulation and control process.

Systems and methods involving implants positioned within implant pockets through minimally invasive entrance incisions, along with related neurostimulatory implants. In some implementations, implants may be folded, rolled, or otherwise compressed to fit within subcutaneous implant pockets, after which they may be decompressed to fit within an implant pocket having one or more dimensions substantially larger than the entrance incision. Such implants may be used for a variety of purposes, including generating electrical energy for various other implants, including neurostimulatory implants located throughout the body.

The present invention relates to a neuromodulation / neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: —at least one control unit (12) configured and arranged to provide stimulation data, and—at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to deliver epidural electrical stimulation to the spinal cord of said mammal, according to said stimulation data, wherein the at least one stimulation unit (14) includes a biocompatible implantable lead (18) configured and arranged to cover at least a portion of the spinal cord of said mammal to deliver epidural electrical stimulation to the dorsal roots innervating the spastic muscles to target neuronal circuitry responsible for spastic episodes.

Systems and methods for fabricating a metal core truss panel with seamlessly embedded features in accordance with embodiments of the invention are illustrated. One embodiment includes a method of treatment for major depressive disorder including obtaining functional imaging data of a patient's brain, identifying disordered lagged correlations between different brain regions using the functional imaging data, identifying a first region of a dorsolateral prefrontal cortex most strongly anti-correlated with an anterior cingulate cortex, identifying a second region of the dorsolateral prefrontal cortex abnormally receiving signals from the anterior cingulate cortex, generating a neurostimulation target as the overlap between the first region and the second region, and applying neurostimulation to the target using a neurostimulation device.

The present disclosure provides a device and a method for neuromodulation treatment. The neuromodulation device comprises a pulse generator to generate electrical pulses and at least one active electrode coupled to the pulse generator. The at least one active electrode has an electrically conductive surface configured to be attached to a leg of a patient. The at least one active electrode stimulates via the electrically conductive surface a nerve of the leg of the patient by the electrical pulses generated by the pulse generator. A control unit controls the pulse generator and sets at least one parameter of the generated electrical pulses. A response detector detects a response of the patient to the nerve stimulation and provides feedback on the detected response to the control unit. For the treatment the control unit determines a treatment setting by varying an initial setting of the at least one parameter of the generated electrical pulses until the detected response of the patient to the nerve stimulation is within a predetermined range.

A system for delivering neurostimulation to a patient may include personalization circuitry and pattern optimization circuitry. The personalization circuitry may include an evaluation input for receiving patient-specific information resulting from a patient survey, a calibration input configured to receive calibration information resulting from a calibration, and a personalization processing circuit. The patient-specific information may include a patient dimension of the neurostimulation. The calibration information may include a response of the patient to the neurostimulation. The personalization processing circuitry may be configured to determine a personalization objective function using the patient dimensions, and determine a personalization model having a model state personalized to the patient's response to the neural stimulation. The pattern optimization circuit may be configured to determine an optimal neurostimulation pattern using the personalization objective function and the personalization model to program the stimulation device to deliver neurostimulation according to the optimal neurostimulation pattern.

A system to analyze data for neurostimulation programming may include capabilities to collect and analyze relevant input data (training data) for training a neurostimulation programming model. In an example, the system may: determine usage of a particular neurostimulation treatment, for a neurostimulation treatment that is associated with a set of parameters used by a neurostimulation device to deliver neurostimulation to a patient; evaluate patient feedback data (e.g., obtained from the patient) associated with the usage of the neurostimulation treatment; calculate, based on the patient feedback data, an amount of training data required to perform training operations on a programming selection model, with such training data being provided at least in part from the patient feedback data and optionally device data. In a further example, the training operations on the programming selection model enable an updated set of parameters to be generated for the neurostimulation device, such as with closed-loop programming.

This application is generally related to systems and methods for providing a medical therapy to a patient by tracking patient activity and adjusting medical therapy based on occurrence of different types of activities performed by the patient while automatically rescheduling stimulation programs based on detected patient activity.

In an illustrative embodiment, methods and systems for treating uterine bleeding include applying, at least every other day in which a subject exhibits or is expected to exhibit menstrual bleeding, neurostimulation therapy in one or more sessions, each session having a duration of at least five minutes, the neurostimulation therapy including applying electrical neurostimulation or mechanical neurostimulation to directly and / or indirectly activate one or more neural targets, the one or more neural targets including a trigeminal cervical complex and / or vagal efferent fibers. The neurostimulation therapy may be configured to enhance platelet function of the subject, thereby reducing a total volume of blood loss over a course of the menstrual bleeding.

An example of a system for delivering neurostimulation and sensing one or more signals may include a programming control circuit and a parameter control circuit. The programming control circuit may be configured to control the delivery of the neurostimulation according to stimulation parameters and the sensing of a target neural signal including target neural responses according to sensing parameters. The parameter control circuit may be configured to determine the stimulation parameters and the sensing parameters and may include a recording analyzer. The recording analyzer may be configured to evaluate a sequence of test recording configurations each including a set of recording configuration parameters selected from the stimulation parameters and the sensing parameters and to determine one or more recording configurations suitable for detection of the target neural responses using an outcome of the evaluation.

This application is generally related to identifying or otherwise programming one or more cycling parameters for operation of an implantable pulse generator to provide a neurostimulation therapy to a patient using a non-paresthesia stimulation pattern. In some embodiments, the cycling parameter is selected by measuring physiological signals during trial stimulation. In other embodiments, multiple cycling parameters are identified for use by the patient using a patient controller device.

An implantable medical system includes a medical device connected to a medical lead with several neural interfaces. The system can selectively generate stimulation signals or sense neurological signals at a selected one of several neural interfaces, such as nerve cuffs. Each neural interface has at least one working electrode that is common to all the neural interfaces. Each neural interface has at least one reference electrode that is dedicated to that interface. A neural interface that has not been selected to stimulate tissue or to sense neurological signals has its dedicated reference electrode floating and not connected to power, ground or any electronic system. Any electrodes that were used for stimulation and are about to be used for neural sensing are grounded for a time interval to discharge any residual electrical charges that may remain due to neural stimulation signals.

Disclosed is an implantable device comprising a control unit and a regulator circuit. The control unit is configured to control, when the implantable device is in an active mode, a stimulus source, the stimulus source configured to deliver neural stimuli to a neural pathway of a patient via at least one stimulus electrode of a plurality of electrodes, the neural stimuli being configured to evoke neural responses from the neural pathway. The regulator circuit is connected via parasitic components to the plurality of electrodes at a connection point. The regulator circuit is configured to provide a high impedance to an AC voltage induced between a pair of the plurality of electrodes, the AC voltage resulting from application of an external oscillating electromagnetic field to the implantable device, wherein the high impedance is provided for a magnitude of the induced AC voltage that is below an activation voltage that is higher than a combined voltage drop across the parasitic components.