290 results about "Neurostimulation" patented technology

The invention relates to the technical field of neural engineering and brain-computer interfaces, in particular to a closed-loop multi-modal nerve stimulation system and method based on time interference, and the system comprises a multi-modal stimulation module which is used for integrating electrical stimulation, magnetic stimulation and optical genetic stimulation, and generating a time interference field domain; the neural state sensing module is used for collecting real-time electroencephalogram signals, blood oxygen concentration and neural metabolite level data; the neural control center is used for fusing neural state data and stimulation parameters, and dynamically adjusting time interference frequency and stimulation intensity through an adaptive algorithm; the time sequence cooperation engine predicts a neural response time phase based on a deep learning model, and optimizes a stimulation time sequence and a mode switching strategy; and the visual interaction platform is used for rendering the nerve activation thermodynamic diagram and the stimulation parameter adjustment curve in real time. Therefore, the problems of adjustment strategy solidification, low adjustment precision, insufficient energy conversion efficiency and the like in the prior art are solved.

The invention discloses a brain deep nerve stimulation method and system based on adaptive adjustment, and relates to the technical field of brain deep nerve regulation, and the method comprises the steps: collecting a local field potential signal of a brain deep target region of a target patient, and extracting a beta frequency band power spectrum density and a gamma frequency band phase synchronization index as neural activity characteristic parameters; determining an individual baseline value and a preset threshold value based on historical data, and outputting a stimulation adjustment trigger signal when the beta frequency band power spectral density exceeds the individual baseline value and the gamma frequency band phase synchronization index is lower than the preset threshold value; in response to the trigger signal, calculating an optimal stimulation parameter combination through a gradient descent optimization algorithm and executing nerve regulation; and monitoring the signal change after regulation and control, calculating a relative change rate and updating a threshold value. Through a two-parameter joint judgment mechanism and a threshold updating strategy, individualized adaptive adjustment of stimulation parameters is realized, and the stimulation accuracy and the treatment effect are improved.

Systems, devices, and methods for neurostimulation using a combination of implantable and external devices to treat pain are disclosed.

The invention discloses a hidden multi-mode brain state real-time monitoring and closed-loop intervention system, and relates to the technical field of intelligent wearable equipment. The system comprises a cap body, and further comprises a multi-point electrode array used for collecting EEG (electroencephalogram) signals, EOG (eye movement) signals and EMG (electromyography) signals of a human body; the brain blood oxygen monitoring module is used for monitoring brain blood oxygen saturation; the signal receiving and processing module is used for preprocessing and analyzing data acquired by the multi-point electrode array and the brain blood oxygen monitoring module; the multi-mode stimulation module is used for implementing sensory and nerve stimulation on the user according to a judgment result of the state judgment module so as to intervene in a drowsiness or attention decline state; and the power supply module and the communication unit are used for providing a working power supply for the modules needing power supply in the system and carrying out data communication with external terminal equipment. The system can monitor the waking degree of the user with high precision and carry out closed-loop feedback intervention by various stimulation means.

The invention belongs to the field of big data, and provides a wearable nerve regulation and control method and system based on cloud AI control, and the method comprises the steps: collecting user data through a wearable nerve regulation and control device worn on the limb part of a user, the user data being physiological data and / or motion data; uploading the user data to a cloud server, wherein the cloud server is provided with an artificial intelligence model; the artificial intelligence model receives the user data, and generates personalized nerve electrical stimulation parameters in combination with pre-stored user historical treatment data and / or medical history data; the cloud server issues the personalized nerve electrical stimulation parameters to the wearable nerve regulation and control device, and the wearable nerve regulation and control device executes transcutaneous nerve electrical stimulation operation based on the personalized nerve electrical stimulation parameters.

A combined neuromodulation and / or neurostimulation system for mitigating locomotor deficits of / or neuronal disorders, especially Parkinson's disease, said system comprises: at least one Deep Brain Stimulation System for providing Deep Brain Stimulation to brain tissue of a subject, at least one control unit, configured and adapted to provide stimulation data, at least one stimulation unit, operatively connected to the at least one control unit, the at least one stimulation unit being configured and adapted to deliver epidural electrical stimulation to the dorsal side of the spinal cord of said subject, and at least one implantable pulse generator, wherein the at least one stimulation unit includes one or more electrodes configured to be implanted epidurally, the one or more electrodes being operatively connected to the at least one IPG.

The present application discloses and describes neurostimulation systems and methods that include, among other features, (i) neural stimulation through audio with dynamic modulation characteristics, (ii) audio content serving and creation based on modulation characteristics, (iii) extending audio tracks while avoiding audio discontinuities, and (iv) non-auditory neurostimulation and methods, including non-auditory neurostimulation for anesthesia recovery.

The utility model provides an expansion device with a nerve monitoring function. The expansion device comprises a base and a function switching circuit, the base is provided with a high-frequency connecting end used for being connected with high-frequency generator equipment, a nerve monitoring connecting end used for being connected with a nerve monitor and an equipment connecting end used for being connected with surgical equipment, and the high-frequency connecting end is matched with the interface type of the equipment connecting end; the function switching circuit comprises a first input end, a second input end and an output end; under the condition that the first input end is electrically connected with the output end, the function switching circuit outputs a high-frequency excitation signal output by the high-frequency generator equipment to the surgical equipment through the output end, so that the surgical equipment realizes an electrocoagulation and electroresection function; under the condition that the second input end is electrically connected with the output end, the function switching circuit transmits the nerve stimulation signal output by the nerve monitor to the surgical equipment so that the surgical equipment can achieve the nerve monitoring function, and therefore the nerve monitoring function can be expanded for the surgical equipment connected with the expansion device in an inserted mode.

A system and method for locating and guiding a peripheral nerve evaluation (PNE) lead. The system comprising an X-ray system to capture images of the patient. The images are processed by the system and are provided to a user to utilize an augmented reality (AR) system for inserting a needle for placing leads for the PNE procedure.

A closed-loop neuromodulation system includes at least one implantable neurostimulator configured to deliver electrical stimulation to a target nerve innervating a muscle; at least one biosignal sensor configured to detect a physiological signal associated with the target muscle, wherein the physiological signal may include an electromyographic (EMG) or electroneurographic (ENG) signal; and a controller operatively coupled to the neurostimulator and the sensor. The controller is configured to receive the physiological signal from the sensor, determine whether the signal satisfies a predefined condition indicative of weakness, strength, fatigue, muscle underactivity, or overstimulation, and, in response to detecting that the condition is satisfied, automatically adjust one or more stimulation parameters selected from amplitude, frequency, pulse width, train duration, or train count.

A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

The invention relates to the technical field of nerve regulation and control, and discloses a nerve stimulation signal output control method and device, equipment and a storage medium, which are used for improving the accuracy of anomaly detection and the flexibility of nerve stimulation signal output control. The nerve stimulation signal output control method comprises the following steps: inputting an original cortex electroencephalogram signal and an original deep electroencephalogram signal into an anomaly analysis model for analysis, and outputting a target anomaly type and a corresponding anomaly degree; selecting a plurality of pulse groups which are arranged in sequence from a preset dynamic stimulation group library according to the target anomaly type and the corresponding anomaly degree, sequentially controlling the cortex electrode or the deep electrode to output the pulse groups, performing recovery detection among the pulse groups, and if the anomaly of the current detection period is continuous, determining that the current detection period is abnormal. And if the abnormality is detected, executing the next pulse group until all the pulse groups are output, if the abnormality is not detected, not executing the remaining pulse groups, and when the abnormality is detected in the next detection period, re-outputting a plurality of pulse groups in sequence.

The invention discloses a programmable electrical nerve stimulation system based on ultrasonic energy supply. The programmable electrical nerve stimulation system comprises an ultrasonic transmitter, a piezoelectric receiver, a rectifier, a power management module, a data demodulation circuit, a control module, an H-bridge driving circuit, a current digital-to-analog converter and an H-bridge circuit, the external ultrasonic transmitter can transmit ultrasonic waves to supply power to the system and transmit data, and the piezoelectric receiver receives ultrasonic signals and converts the ultrasonic signals into alternating current signals. The rectifier and the power management module can convert alternating current signals into direct current signals to provide power for other circuits of the system, the data demodulation circuit processes the alternating current signals to recover data information in ultrasonic waves, the control module controls the H-bridge driving circuit and the current digital-to-analog converter according to the data information, and finally electrical stimulation is achieved through the H-bridge. The system provided by the invention has the characteristics of wireless energy supply, high safety and programmable stimulation parameters, and can realize accurate control of output current parameters.

A system may include a neurostimulator and a processing system configured to provide a stimulation effects map by testing stimulation parameter sets from a plurality of available stimulation parameter sets, acquiring clinical effect data indicative of a patient response to electrical energy delivered to the tissue using at least a first subset of the tested stimulation parameter sets, acquiring sensed data indicative of a sensed response to the electrical energy delivered to the tissue using at least a second subset of the tested stimulation parameter sets, and evaluating parameter sets from the plurality of untested stimulation parameter sets including for each of the evaluated parameter sets, determining an estimated response by estimating at least one of the patient response or the sensed response to the electrical energy using the acquired clinical effect data and the acquired sensed data. A stimulation parameter set may be chosen based on the map.

The present disclosure provides systems and methods for providing neurostimulation therapy according to gait features. The gait features may be analyzed to develop a patient model between gait features and optimal settings for a neurostimulation therapy using machine learning operations. The model is used to control ongoing neurostimulation therapy for the patient.

In an illustrative embodiment, methods and systems include delivering neurostimulation therapy, including delivering a first pulse series including a) delivering a suprathreshold cathodic pulse to a first electrode to stimulate a first neural structure, thereby producing a corresponding anodic pulse on a second electrode, and b) delivering a charge-balancing subthreshold anodic pulse with reversed polarity of the suprathreshold cathodic pulse to the first electrode, thereby producing a corresponding cathodic pulse on the second electrode, and delivering a second pulse series including c) delivering a suprathreshold cathodic pulse to the second electrode to stimulate a second neural structure, thereby producing a corresponding anodic pulse on the first electrode, and d) delivering a charge-balancing subthreshold anodic pulse with reversed polarity of the suprathreshold cathodic pulse to the second electrode, thereby producing a corresponding cathodic pulse on the first electrode.

Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for optimizing neurostimulation therapy for treatment of neurological and neurodegenerative diseases. Joint dynamic causal modeling and biophysics modeling are used for optimization of the stimulation targets and parameters. In particular, methods of performing neuromodulation to suppress b-band oscillations in the brain of a subject are provided.

The present disclosure relates to a neurostimulation system, in particular for Cortical and / or Deep Brain Stimulation and / or Central Nervous System (CNS) neurostimulation / neuromodulation and / or Peripheral Nervous System (PNS) neurostimulation / neuromodulation and / or Vagus Nerve Stimulation, comprising:at least one implant unit comprising:at least one first antenna, andat least one lead having at least one electrode array with at least one electrode; andat least one wearable device comprising at least one second antenna,wherein the at least one wearable device is configured to wirelessly control and wirelessly communicate with the at least one implant unit, and wherein the at least one electrode is made of reduced graphene oxide, such as hydrothermally reduced graphene oxide.

The application provides a wireless and battery-free brain nerve stimulator and a preparation method. The brain nerve stimulator can be driven by a mobile phone loudspeaker, and a resonator designed can effectively amplify a piezoelectric signal. The brain nerve stimulator comprises two parts: a base provided with implantable nerve stimulation electrodes and a resonant cavity device connected through magnetic coupling. The design scheme of the brain nerve stimulator provides a general method for inhibiting epilepsy. The brain nerve stimulator can be extended to target brain deep layers or surface areas and peripheral nervous systems. A stimulation mode can be wirelessly transmitted and controlled. It is proved by electroencephalogram recording of free-moving mice that the wireless nerve stimulator can effectively relieve seizure events of the epileptic mice in vivo.

The invention relates to an ejaculation control nerve regulation and control method and device based on electric pulse dynamic adjustment, and belongs to the field of medical instrument electronic products, and the method comprises the steps: S1, judging whether the positions of two electrodes are effective stimulation positions or not according to the collected contact resistance of the two electrodes at the dorsal root of the penis for stimulating the dorsal root of the penis; if so, entering the next step; otherwise, adjusting the positions of the two electrodes until the effective positions are judged, and then entering the next step; s2, selecting at least one working mode of a high-frequency mode, a low-frequency mode, a frequency mixing mode, a frequency mixing group mode and a modulation frequency mixing mode, and outputting electric pulse signals corresponding to the frequency modes to the dorsal root nerves of the penis through the two electrodes for electrical stimulation; s3, in the electrical stimulation process, according to the collected contact resistance values of the two electrodes, the output energy of the electric pulse signal is dynamically adjusted, and the dynamic balance of the charging and discharging process is controlled; therefore, the effectiveness and safety of electrical stimulation are ensured. The ejaculation control nerve regulation is safer and more effective.

This invention discloses a neurostimulation system, comprising: a stimulator and a lead wire; the stimulator includes: a connection channel and a control module; the lead wire includes: an implantation end inserted into a target point and a connection end inserted into the connection channel; the connection end is provided with an identification circuit consisting of a positioning ring and multiple coding rings; the type of the lead wire corresponds to the shorting method between the positioning ring and the coding rings; the connection channel is provided with a cooperating circuit connected to the identification circuit; wherein, the control module is connected to the cooperating circuit and configured to: when the connection end of the lead wire is inserted into the connection channel, read the address bit combination of the identification circuit; and determine the lead wire type according to the address bit combination and a pre-stored address bit combination library corresponding to the lead wire type. The technical solution of this invention improves configuration efficiency and accuracy by forming an address code through shorting the positioning ring and the coding ring, allowing the stimulator to read and match the pre-stored library.

The present application relates to the technical field of neuromodulation, and discloses a neuromodulation system and method for dual-task gated taVNS. The present application collects kinematic data and cognitive performance data of a patient performing a motor-cognitive dual task; obtains an objective maximum load paradigm according to the kinematic data and the cognitive performance data, obtains a subjective maximum load paradigm according to a subjective work load score, and combines the two to obtain a maximum intensity dual-task load paradigm; applies multiple trial dual-task training to the patient under the maximum intensity dual-task load paradigm, and in each trial, determines in real time whether to trigger transcutaneous auricular vagus nerve stimulation according to a dual-dimension gating condition, triggers to generate a stimulation signal when the cognitive correctness condition and the motor safety condition are both satisfied, and suspends the presentation of a new task during the stimulation duration. The present application realizes precise coupling of dual-task training and neuromodulation in the time dimension, and improves the timing specificity and individualization of neuromodulation.

Embodiments include implantable neurostimulation leads configured to reduce current leakage following implantation in a patient's body, and methods of manufacturing such leads. A lead includes a lead body with proximal apertures and distal apertures; a lumen extending through the lead body; electrodes at a distal portion of the lead body and connector interfaces at a proximal portion of the lead body; conductors extending through the lead body, with their proximal ends exiting via respective proximal apertures to couple with a respective connector interfaces, and their distal ends exiting the interior of the lead body via respective distal apertures to couple with a respective electrodes; and an electrically nonconductive filler element for occupying gaps in the interior of the lead body resulting from the exit of conductors from the lead body.

A system and method of neurostimulation that is coupled with spinal fixation or the spine, implanted at the time of spine surgery, and allowing for a delayed minimally invasive connection to a stimulation source. The components of the system include the conduit anchor that secures to the instrumentation or spine; conduit housing through which leads enter and channels are isolated; the conduit cap to protect the implant; the lead adaptor entry port, wherein leads enter and channels are isolated; the lead adaptor pin housing, which contains contact pins; the keyed MIS tube, through which the lead adaptor is implanted in a second surgery; a grooved applicator to assist with lead placement; and an encircling clip to assist in securing a lead. The method of generating a signal in the frequency domain is described. The method of minimally invasive stimulation trial placement is described.

Neurostimulation therapy can be efficiently controlled based on information from an acceleration signal, such as can be obtained from an accelerometer. In an example, the accelerometer can be implanted in a cervical region or submandibular region of a patient. Circuitry can be configured to identify a first series of respiration phase transition events in the acceleration signal and, in response, provide the neurostimulation therapy synchronously with an inspiration phase of a patient's respirator cycle. In an example, m absence of identifying the first series of respiration phase transition events in the acceleration signal, the neurostimulation therapy can be provided asynchronously with the patient's respiratory cycle.

Disclosed is an implantable device for controllably delivering a neural stimulus. The device comprises: a plurality of electrodes including one or more stimulus electrodes and one or more sense electrodes; a stimulus source configured to provide a neural stimulus to be delivered via the one or more stimulus electrodes to a neural pathway of a patient in order to evoke a neural response on the neural pathway; measurement circuitry configured to process a signal window sensed at the one or more sense electrodes subsequent to the delivered neural stimulus, the sensed signal window including an evoked neural response; and a control unit. The control unit is configured to: control the stimulus source to provide the neural stimulus according to a stimulus parameter; estimate, using a detector, a location of the evoked neural response within the sensed signal window; determine, based on the location of the evoked neural response within the sensed signal window, whether truncation of the evoked neural response by the sensed signal window is occurring; and mitigate, based on the determination, the truncation of the evoked neural response.

Embodiments described herein relate to systems, devices, and methods for monitoring brain activity and delivering electrical brain stimulation to a patient. In some embodiments, a system can deliver responsive electrical stimulation in a closed-loop manner and can offer real-time or near real-time monitoring of induced neurophysiological effects. After detecting a targeted brain pattern (i.e., an epileptic seizure), the system may deliver high-intensity ultra-short electrical stimulation impulses non-invasively or minimal-invasively to diminish or stop the neural oscillations underlying the epileptic seizure. The stimuli are delivered in time and space, relative to the emerging seizure rhythm patterns, such that they diminish or terminate the seizure. The system may include an implantable device including one or more electrodes electrically coupled to one or more processors. The processor(s) may be operatively coupled to a memory, one or more communication modules, and may optionally be coupled to a battery and one or more additional sensor(s).

A system may include a neurostimulator and a processing system. The neurostimulator may be configured to deliver electrical energy according to a stimulation parameter set. The stimulation parameter set may include at least one adjustable parameter. The processing system may be configured to perform a testing process to test delivering electrical energy by automatically progressing through a sequence of values for the at least one adjustable parameter in the parameter set. A first value and a second value in the sequence of values are separated by an initial parameter change interval and a second to last value and the last value in the sequence of values are separated by a final parameter change interval. Progressing through the sequence of values includes reducing the parameter change interval from the initial parameter change interval to the final parameter change interval.

Disclosed herein is a neurostimulation system comprising: a stimulation device comprising a stimulator configured to provide electrical stimulation to one or more branches of a nerve of a user or one or more muscles of the user; a memory storing machine readable instructions; and a control system including one or more processors configured to execute the machine-readable instructions to implement an adaptive process. The adaptation procedure is configured to adapt the user to a neurostimulation treatment for assisting the user in breathing prior to the start of a treatment session by setting a stimulation pattern of the system to a starting stimulation pattern, the initial stimulation pattern is configured such that a level of electrical stimulation applied in the initial stimulation pattern is weaker than a level required to provide the neurostimulation therapy; causing the stimulation device to provide the electrical stimulation to the one or more branches or the one or more muscles of the nerve in the initial stimulation mode; receiving response data from the user or obtained by measuring a physiological output of the user; processing the response data to determine a stimulus response; altering the stimulation pattern to increase the level of electrical stimulation applied in the pattern when the stimulation response is within a tolerable threshold range; and stopping stimulation when the stimulation response is not within the tolerable threshold range or the stimulation pattern is at a predefined limit.

A system for providing neurostimulation to a patient includes a pulse generator having a housing. The implantable neurostimulation lead is configured to connect with a pulse generator, and the pulse generator is configured to generate a plurality of electrical pulses for delivering neurostimulation therapy through the lead to a patient when the lead is implanted at a target location. The lead includes one or more conductors extending from a proximal end of the lead to one or more neurostimulation electrodes disposed at or near a distal end of the lead. The lead comprises an energy absorber comprising a carbon nanotube material and extending substantially along the length of the one or more conductors.