883 results about "General method" patented technology

A combinatorial method that uses statistics and DNA sequence analysis rapidly assesses the functional and structural importance of individual protein side chains to binding interactions. This general method, termed “shotgun scanning”, enables the rapid mapping of functional protein and peptide epitopes and is suitable for high throughput proteomics.

Polymeric delivery devices have been developed which combine high loading / high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more preferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.

A new general method for building hybrid processors achieves higher performance in applications by allowing more powerful, tightly-coupled instruction set extensions to be implemented in reconfigurable logic. New instructions set configurations can be discovered and designed by automatic and semi-automatic methods. Improved reconfigurable execution units support deep pipelining, addition of additional registers and register files, compound instructions with many source and destination registers and wide data paths. New interface methods allow lower latency, higher bandwidth connections between hybrid processors and other logic.

The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues to non-essential regions of the proteins or substituting cysteine residues for non-essential amino acids in the proteins using site-directed mutagenesis and then covalently coupling a cysteine-reactive polymer or other type of cysteine-reactive moiety to the proteins via the added cysteine residue. Disclosed herein are preferred sites for adding cysteine residues or introducing cysteine substitutions into the proteins, and the proteins and protein derivatives produced thereby.

The invention concerns with the molecular biology, molecular genetics and biotechnology and can be used in the gene-therapy in the medicine and the agriculture or in the industrial biotechnology for a gene-specific silencing of the disease-related genes or the genes interfering a buildup of a product, respectively. The approach is suggested for changing of genetic properties of an organism by RNA interference leading to gene-specific silencing of a selected gene by RNA molecules, that are complementary in a parallel orientation (pcRNA) to mRNA of the selected gene; pcRNA are synthesized in vivo or in vitro on the artificial DNA sequence possessing symmetrical nucleotide ordering (mirror inversion) in respect to the nucleotide sequence of the gene. The invention suggests the general approach for changing of genetic properties of an organism and is based on the biological properties of mirror inversions of nucleotide sequences that are realized in RNA interference and gene-specific silencing.

A general method is described for producing an inexpensive touchscreen system that provides accurate positional information and compensates for manufacturing variations without complicated sensor arrangements. Utilizing a set of sensed signals that are unique to each location on the touchscreen sensor, equations for X and Y are derived via curve fitting methods. The coefficients of the equations are stored with the sensor. During touchscreen operation the coefficients are used to calculate X and Y to the desired accuracy directly and independently.

A car navigation device using a forward real video and a control method thereof are disclosed. The car navigation device using a forward real video along the travel direction of a vehicle, comprises a camera that photographs the forward real video and outputs the photographed video on a screen, a GPS receiver that receives current position information of the vehicle from a satellite, and a navigation main module that receives the current position information of the vehicle from the GPS receiver, obtains more accurate current position information through calibration using a speed sensor and a gyro, extracts TBT information based on the obtained accurate current position information and user's set destination point information by a general method, and overlays the TBT information on the screen containing the forward real video along the direction of a destination point.

An improved gene sequence optimization method, the systematic optimization method, is described for boosting the recombinant expression of genes in bacteria, yeast, insect and mammalian cells. This general method takes into account of multiple, preferably most or all, of the parameters and factors affecting protein expression including codon usage, tRNA usage, GC-content, ribosome binding sequences, promoter, 5′-UTR, ORF and 3′-UTR sequences of the genes to improve and optimize the gene sequences to boost the protein expression of the genes in bacteria, yeast, insect and mammalian cells. In particular, the invention relates to a system and a method for sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm. The improved systematic optimization method can be incorporated into a software for more efficient optimization.

Methods and systems of creating and sharing structured reports. In one embodiment, a system for creating structured reports includes a business logic server and a structured object repository configured to hold at plurality of structured report templates. The structured report templates are based on a common schema. The system also includes at least one inbound message device configured to receive data from at least one source of patient data in a message-oriented protocol, to convert the data from the at least one source of patient data to a format recognized by the business logic server, and to send the converted data to the business logic server. The business logic server may be configured to obtain the at least one structured report template and to create a structured report by inserting the converted data into the at least one structured report template.

Wideband signal generation systems and methods are provided which employ frequency interleaving for generating wideband signals. A general method increases a digitally synthesized signal's bandwidth by frequency interleaving multiple digitally synthesized signal sources of narrower bandwidth. Frequency interleaving creates a continuous wideband signal by summing multiple narrower band signals that overlap in frequency. According to certain embodiments, digital signal processing (DSP) and analog mixing are used to create the multiple narrower band signals such that a high fidelity, continuous wideband signal is produced when the multiple narrower band signals are summed.

A car navigation device using a forward real video and a control method thereof are disclosed. The car navigation device using a forward real video along the travel direction of a vehicle, comprises a camera that photographs the forward real video and outputs the photographed video on a screen, a GPS receiver that receives current position information of the vehicle from a satellite, and a navigation main module that receives the current position information of the vehicle from the GPS receiver, obtains more accurate current position information through calibration using a speed sensor and a gyro, extracts TBT information based on the obtained accurate current position information and user's set destination point information by a general method, and overlays the TBT information on the screen containing the forward real video along the direction of a destination point.

The general method and apparatus of the invention comprises an adjustable strap system to secure one object to another, or one or more objects in a folded, rolled, or gathered position. In one embodiment, the invention comprises a single elongated strap of material having a first end and a second end, one end narrower than the other, a first side and a second side, four fastening surfaces or fasteners, three on one side and one on the opposite side, two positioned on each side of the narrow strap, and two positioned on the wide strap same side opposite the narrow strap. In the fastened state, the adjustable strap system secures the narrow strap by mating four opposing fastening surfaces thereby resulting in a dual locking adjustable strap system. In an alternative embodiment, two separate straps may be utilized with the dual locking mechanism of the present invention.

A system for device-aware content delivery includes a distributor and a database. The distributor includes modules for determining the type of portable computing device and delivering content that is operable on the specific type of portable computing device and uses the unique capabilities of the identified portable computing device. The database includes different profiles for different portable computing devices and gives information that allows those portable computing devices to be identified by type and distinguished from each other portable computing devices during a discovery or interrogation phase. The database also stores different versions of content adapted for operation on specific device types, such that once the device type has been identified, the matching content can be sent to the portable computing device, installed and executed. The matching content is programmatic action specific to the portable computing device. The present invention also includes a number of novel methods including: a method device-aware content delivery, a general method for automatically determining a device type, a method for determining device type using a Bluetooth® protocol and a method for determining a device type using an infrared device access protocol.

The invention discloses a multi-version parallel test method for web pages and a server. A web framework receives a page rendering request which is submitted by a web application for rendering a certain page of the web; before a page rendering engine renders the certain page of the web, a page processing logic is skipped from a page processing module of the web framework and / or a page rendering module of the rendering engine to the same test execution module for executing AB test on the certain page of the web, and a selected reversion scheme of the certain page of the web is returned to the web framework; the web page is rendered according to the selected reversion scheme of the certain page of the web. A high-efficiency and flexible general method for multi-version parallel test of the web page and a system are realized and are suitable for different web frameworks and different rendering engines; the problem of system invasion caused by multi-version parallel test is solved; the multi-version parallel test execution logic can be reused and is convenient to expand; a test strategy can be flexibly adjusted and can dynamically take effect instead of being issued.

Oxygenate feedstocks derived from biomass are converted to a variety of fuels including gas, jet, and diesel fuel range hydrocarbons. General methods are provided including hydrolysis, dehydration, hydrogenation, condensation, oligomerization, and / or a polishing hydrotreating.

The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound with a second compound thereby to form a third compound selected from the formulas: and stereoisomers thereof, and performing a macrolactonization of the third compound. The present invention also provides chemical compounds, and methods for producing such chemical compounds, that are useful in producing epothilones and analogs and derivatives thereof.

The invention discloses a falling-down detection device and method. A gyroscope, an accelerometer and a magnetometer are respectively used for measuring to obtain angular speed data, accelerated speed data and terrestrial magnetism data; the angular speed data are utilized to solve a basic posture angle, and the accelerated speed data and the terrestrial magnetism data are utilized to carry out noise self-adapted Kalman fusion filtering on the basic posture angle to obtain a final posture angle. The angular speed data and the accelerated speed data are used tor carrying out movable and static state judgment on a user; when the user is static, whether the user lies down or not is judged according to the posture angle; if the user lies down, conscious / unconscious screening and falling-down stress assessment of lying-down movement is carried out to judge whether the user falls down or not in a combined manner; when the user falls down, an alarm is sent out. According to the falling-down detection device and method disclosed by the invention, the obtained posture angle is more accurate than that obtained by using a common method; meanwhile, the conscious / unconscious screening and the falling-down stress assessment are used for carrying out combined judgment so that a falling-down judging result is accurate and the false alarm rate is reduced.

The invention relates to a method for constructing a full-coverage all-direction resource sharing family endowment service system, belonging to the field of the information processing and transmission technology. The invention is technically characterized by mainly comprising a system platform, an Internet website subsystem, a call platform subsystem, an Internet aged-people interaction subsystem, a 120 first-aid supplementary information service subsystem, a home delivery logistics subsystem, home service scheduling subsystem and a call termination subsystem, wherein the call termination subsystem mainly comprises a computer, dual tone multi-frequency signal receiving and transmitting equipment, a telephone terminal and computer software. The family endowment service system constructed with the method can be used as an integrated network service system in the community and further as a digital information platform. The method of the invention is not only a special method applied to a special object but also a general method for constructing an information processing and transmission system serving the public. For example, the method of the invention can be used for constructing the full-coverage all-direction resource sharing life insurance service system.

The invention discloses a new Chinese medicinal composition for treating diseases of weakness of spleen and stomach and indigestion, and a preparation method thereof. The Chinese medicinal composition mainly comprises the following raw material medicaments: stir-fried medicated leaven, scorch-fried crataegus, stir-fried barley sprout, scorch-fried areca, chicken's gizzard-membrane, cassia bark, dried ginger, rhizoma corydalis, nutgrass galingale rhizome, costustoot, combined spicebush root, Indian buead, swordlike atractylodes rhizome, officinal magnolia bark, fortune eupatorium herb, fructus amomi, tsaoko amomum fruit, nutmeg, fresh membranous milkvetch root, pilose asiabell root, common yam rhizome, Chinese angelica, white paeony root, baical skullcap root, lightyellow sophora root, fresh rehmannia root, tree peony bark, combined spicebush root, anemarrhena asphodeloides bunge, Mongolian snakegourd root, common lophatherum herb, ash bark, bunge cherry seed, fructus cannabis and rhubarb. The Chinese medicinal composition can be prepared into any common oral preparation by a general method for preparing a Chinese medicinal preparation. The Chinese medicinal composition can obviously improve symptoms of the weakness of spleen and the indigestion, obviously improves stomach duct dull pain, glomus and fullness, and abdominal distension, obviously improves appetite, improves diet amount, and has exact clinical curative effect, obvious curative effect and quick response. The Chinese medicinal composition basically combines medicinal and edible medicaments specified in national pharmacopoeia, so the Chinese medicinal composition has the advantages of low cost, basically no toxic or side effects and the like.

This application discloses phosphoramidate and phosphonoamidate prodrugs of alcohol-based therapeutic agents, such as nucleosides, nucleotides, acyclonucleosides, C-nucleosides, and C-nucleotides, and use of these prodrugs for treatment of diseases or disorders, including infectious diseases and cancers. This application also discloses a general method for enhancing bioavailability and / or liver-targeting property of alcohol drugs through converting the alcohol drugs to phosphoramidate or phosphonoamidate prodrugs, and methods of preparation of these prodrugs.

Methods and compositions for agonizing a type-2 orexin receptor (OX2R) in a cell determined to be in need thereof, including the general method of (a) administering to a subject a cyclic guanidinyl OX2R agonist and (b) detecting a resultant enhanced wakefulness or increased resistance to diet-induced accumulation of body fat, or abbreviated recovery from general anesthesia or jet lag.

This invention describes a novel method of producing bioactive recombinant proteins from plants. General methods of designing and engineering plants for expression and production of such proteins are also disclosed. Methods for the expression of Transforming Growth Factor-β (TGF-β) proteins, such as Müllerian Inhibiting Substance (MIS), in plants, and methods of producing recombinant proteins from plants are specifically disclosed. Furthermore, the present invention provides methodology for the direct expression and production of a bioactive C-terminal fragment of a TGF-β protein, such as C-terminal MIS. The new method is more cost-effective than other large-scale expression systems, by eliminating the need for costly cell culture and fermentation manufacturing facilities.

A general method and apparatus for treating materials at high speed comprises the steps of dissolving a relatively high concentration ozone gas in a solvent at a relatively low predetermined temperature T1 to form an ozone-solvent solution with a relatively high dissolved ozone concentration, and heating either the ozone-water solution or the material to be treated or both, the ozone-solvent solution and the material to be oxidized with a point-of-use heater to quickly increase the temperature to a predetermined higher temperature T2>T1, and applying the ozone-solvent solution to said material(s) whereby the heated ozone-water solution will have a much higher dissolved ozone concentration at said higher temperature, than could be achieved if the ozone gas was initially dissolved in water at said higher temperature.

Precoding for multiple transmission streams in multiple antenna systems. Disclosed herein is a general method that transmits signal from multiple antennas using a one / two dimensional precoder. This precoder is fixed in a given resource block (RB) or slot, which is composed of P subcarriers and Q OFDM symbols (where the values for P and Q are greater than or equal to 1). The precoder in each resource block may take same or different values, which span the two dimensional time-frequency grid. The precoder is chosen as a function of either logical frequency index or physical frequency index of the RB.

The present invention discloses methods for enhancing the wear-resistance of polymers, the resulting polymers, and in vivo implants made from such polymers. One aspect of this invention presents a method whereby a polymer is irradiated, preferably with gamma radiation, then thermally treated, such as by remelting of annealing. The resulting polymeric composition preferably has its most oxidized surface layer removed. Another aspect of the invention presents a general method for optimizing the wear resistance and desirable physical and / or chemical properties of a polymer by crosslinking and thermally treating it. The resulting polymeric compositions is wear-resistant and may be fabricated into an in vivo implant.