89results about How to "Effective treatment" patented technology

The invention relates to a traditional Chinese medicine composition with functions of tonifying qi and nourishing blood for livestock. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-30 parts of astragalus membranaceus, 10-40 parts of spina gleditsiae, 10-20 parts of angelica sinensis, 10-20 parts of codonopsis pilosula, 10-30 parts of uniflower swisscentaury root, 10-30 parts of ligusticum wallichii, 10-20 parts of cowherb seed, 10-20 parts of fruit of liquidambar formosana hance and 1-10 parts of iron sucrose. The traditional Chinese medicine composition is scientific and reasonable in component, free of toxic and side effects and medicine residue, convenient to take and low in cost, has the functions of tonifying qi and nourishing blood, stimulating the menstrual flow and prompting lactation, and is capable of effectively treating diseases of postpartum hypogalactia, breast milk stoppage and the like which are normal in livestock.

The invention belongs to the field of biological medicine, and discloses a chicoric acid (CA)-loaded tetrahedral framework nucleic acid (tFNA) nano preparation for treating acute gouty arthritis. According to the preparation, tFNA formed by self-assembly is taken as a carrier, and a natural active ingredient CA is loaded to form a CA-tFNA compound. The compound overcomes the defects that CA is poor in water solubility and low in bioavailability, and existing drugs are weak in targeting and large in side effect. Through the targeted delivery and synergistic effect of tFNA, the preparation can be effectively enriched in inflammatory joints, significantly inhibit NF-kappa B signal pathways, and down-regulate the expression of key proinflammatory factors such as TNF-alpha and IL-1beta, so that joint swelling and synovial tissue damage are relieved, and repair is promoted. Experiments show that the traditional Chinese medicine composition is remarkable in curative effect and good in safety, and a novel efficient treatment strategy is provided for acute gouty arthritis.

The present invention relates to novel multispecific binding proteins for cancer therapy, i.e. B7H6 / CD3 binding proteins. The invention further relates to nucleic acids encoding said proteins; methods for the production of said proteins; host cells expressing or capable of expressing said proteins; compositions comprising said proteins; and uses of said proteins or said compositions, in particular in the field of cancer diseases for therapeutic purposes.

The present invention provides a pharmaceutical composition that suppresses cell proliferation and has an anti-cancer effect with respect to pancreatic cancer and bile duct cancer. The present invention relates to a pharmaceutical composition containing, as an active ingredient, a substance that reduces an intracellular content of a ZIC5 protein, where the composition is used for treatment of pancreatic cancer or bile duct cancer; the pharmaceutical composition further containing an anti-cancer agent other than the substance that reduces the intracellular content of the ZIC5 protein; and the pharmaceutical composition further containing an anti-cancer agent other than the substance that reduces the intracellular content of the ZIC5 protein.

Therapeutic compositions and methods for treatment of attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD) include dosage forms that deliver a therapeutic amount of active drug in a delayed and controlled release formulation. The dosage form can be administered at night and drug release is delayed for from 3 to 8 hours, followed by an ascending release rate.

This invention discloses a near-infrared light-exciteable composite nanosheet, its preparation method, and its applications, belonging to the field of biomedical technology. The method includes the following steps: mixing epigallocatechin gallate with a Ti3C2 nanosheet dispersion, ultrasonically reacting, adding silver salt, and continuing stirring in the dark; after the reaction is complete, washing and separating to obtain MXene-EGCG@Ag composite nanosheets. The composite nanosheets provided by this invention possess near-infrared light-exciteable properties and can be used to prepare medically acceptable dosage forms such as hydrogels for the treatment of periodontitis. The preparation method provided by this invention is simple, the raw materials are readily available, and it exhibits significant antibacterial and anti-inflammatory effects, enabling further widespread application.

The invention provides lipid nanoparticles taking zinc phosphate as an inner core, a preparation method of the lipid nanoparticles and a medicine for treating aortic aneurysm, and relates to the technical field of biological medicines. The lipid nanoparticles provided by the invention comprise zinc phosphate nanoparticles, DOPA (Dioctyl-Phthalate Polyamide), ionizable cationic lipid, cholesterol and PEG (Polyethylene Glycol) lipid, the zinc phosphate nano-particles are inner cores of the lipid nano-particles. The lipid nanoparticles have excellent biocompatibility and safety and stable structure, and can improve the stability and delivery efficiency of nucleic acid (such as FBN1mRNA) as a carrier, thereby realizing effective treatment of diseases. According to the medicine for treating the aortic aneurysm, provided by the invention, accurate delivery of FBN1mRNA and expression in FBN1 cells can be realized, and angiogenesis and repair are promoted, so that accurate treatment of the aortic aneurysm is realized.

The application relates to a balloon catheter, characterized in that the balloon catheter comprises a balloon, a catheter, a terminal tube, a developing ring, a catheter seat, a stress tube and a catheter sleeve, the catheter comprises an inner tube and an outer tube, the outer tube is sleeved outside the inner tube, the distal end of the inner tube is connected with the proximal end of the terminal tube, the distal end of the balloon is fixed on the outer surface of the terminal tube and / or the inner tube, the proximal end of the balloon is fixed on the outer surface of the distal end of the outer tube, the developing ring is arranged on the inner tube in the balloon, the stress tube is fixed on the distal end of the catheter seat, the proximal end of the inner tube is fixed inside the proximal end of the catheter seat through the stress tube and the catheter seat, the proximal end of the outer tube is fixed inside the distal end of the catheter seat through the stress tube and the catheter seat, and the catheter sleeve is sleeved outside the balloon. The balloon catheter can effectively treat arterial or venous stenosis and the like.

This utility model belongs to the field of postpartum care, specifically a postpartum hemorrhoid reduction and swelling-reducing device. Addressing the problem that postpartum hemorrhoids have an incidence rate as high as 70%-80%, and that the acute phase is characterized by unrelieved pain caused by incarcerated hemorrhoids due to contraindications to medications during lactation, the risk of perineal wound infection, and limitations of postpartum surgery, the proposed solution includes a support block with an air bladder covering its outer wall. One end of the support block has an integrally formed support spherical block, and another end has an integrally formed liquid bladder covering the support spherical block. The liquid bladder draws in lubricating fluid and applies it around the hemorrhoids, reducing friction and making it easier to push the hemorrhoids back into the body. Simultaneously, the massage effect of the air bladder promotes perianal blood circulation, accelerating the reduction of swelling and recovery of the hemorrhoids. This dual-action mechanism makes the treatment effect of this swelling-reducing device significantly superior to traditional methods, suitable for postpartum hemorrhoid patients of varying degrees.

The present application relates to a kind of FAPi, FAPi intermediate, FAPi modified HSP47siRNA loaded lipid nanoparticles and its application, belong to the field of biological medicine.The inventor constructs a kind of HSP47siRNA loaded lipid nanoparticles (FAPi-LNP / siHSP47) of Fibroblast activation protein inhibitor (FAPi) modification in view of the problems of high morbidity of existing technology liver fibrosis, so far no medicine, and ordinary LNP mainly target delivery to liver parenchymal cell after intravenous injection, and cannot enter the activated hepatic stellate cell (HSC) that plays a key role in the development of liver fibrosis.The expression of HSP47 can be effectively knocked down by the mediation of the high expression of Fibroblast activation protein on the surface of activated HSC, and the content of liver fibrosis marker protein a-SMA can be reduced.Compared with LNP without FAPi modification, FAPi-LNP / siHSP47 actively targets activated HSC after entering liver tissue, enters cell under the mediation of FAP, significantly knocks down the expression of HSP47, reduces collagen deposition, and significantly improves liver fibrosis.

A myoregulin inhibitor such as an antisense oligonucleotide against myoregulin or an anti-myoregulin antibody is used as an active ingredient of a prophylactic or therapeutic agent for a muscle disease such as muscular dystrophy, inclusion body myositis, amyotrophic lateral sclerosis, disused muscular atrophy, and sarcopenia.

An integrated eustachian tube sustained-release drainage device is provided with a drug-carryable, degradable and compressible elastic support, a drainage mechanism for draining liquid in the eustachian tube and a degradable connecting line, the drainage mechanism being fixed to the front end of the elastic support through the connecting line. The integrated eustachian tube drainage device can effectively drain the effusion and secretion in the eustachian tube, improve the ventilation and drainage conditions of the middle ear. The elastic support is composed of a degradable material and can carry drugs to continuously release the drugs, effectively treating diseases such as eustachian tube inflammation and reducing inflammatory reactions and promoting mucosal repair. Moreover, the degradable material of the elastic support reduces the long-term impact on the patient and reduces the risk of infection. The integrated eustachian tube drainage device can also be stably fixed in the eustachian tube, thereby improving the reliability of treatment.

The invention discloses application of a reagent for detecting the expression quantity of BCKDK protein in preparation of a kit. The kit is used for at least one of detecting whether breast tissue to be detected is tumor tissue or not, evaluating stages of breast cancer, evaluating the prognosis effect of breast cancer patients and evaluating the treatment effect of breast cancer drugs or DNA damage drugs. Therefore, by detecting the expression quantity of the BCKDK protein in the to-be-detected breast tissue, whether the to-be-detected breast tissue is a tumor tissue or not can be determined, or the stages of the breast cancer of an individual from the to-be-detected breast tissue can be determined; if the breast cancer patient is in the treatment stage, the prognosis effect of the breast cancer patient or the treatment effect of the applied medicine can be determined by detecting the expression quantity of the BCKDK protein in the breast tissue to be detected.

An electro-acupuncture stimulation system comprises a first stimulation unit, a second stimulation unit and a control unit, the first stimulation unit is used for collecting a sensing signal of a first stimulation area and performing electro-acupuncture stimulation on the first stimulation area, the second stimulation unit is used for collecting a sensing signal of a second stimulation area and performing electro-acupuncture stimulation on the second stimulation area, and the control unit controls the first stimulation unit and the second stimulation unit to perform electro-acupuncture stimulation according to the sensing signals; the control unit comprises a hierarchical coordination module for distributing off-target stimulation parameters, which is divided into a perception layer, a decision layer and an execution layer; the perception layer uploads the sensing signals of the target points to the decision layer in real time; the decision layer distributes the stimulation parameters of the off-target points based on a target point position correlation method; and the execution layer adjusts the output stimulation parameters of the adjacent target points according to the instructions of the decision layer to maintain the total stimulation energy consistent with that before off-target. The present application utilizes the synergistic effect of multiple neural pathways to enhance the contraction function of the pelvic floor muscles and improve the stimulation efficiency.

This invention provides a traditional Chinese medicine composition for treating viral pneumonia in calves, its preparation method, and its application, belonging to the field of veterinary drug technology. The traditional Chinese medicine composition provided by this invention comprises the following raw materials in parts by weight: 15-20 parts of Gentiana scabra, 15-20 parts of Gardenia jasminoides, 15-20 parts of Scutellaria baicalensis, 10-15 parts of Bupleurum chinense, 25-35 parts of Rehmannia glutinosa, 25-35 parts of Plantago asiatica, 15-20 parts of Alisma plantago-aquatica, 25-35 parts of Akebia trifoliata, 10-15 parts of Angelica sinensis, 25-35 parts of Smilax glabra, 15-20 parts of Dioscorea hypoglauca, 25-35 parts of Dictamnus dasycarpus, and 10-15 parts of Glycyrrhiza uralensis (processed). The traditional Chinese medicine composition of this invention can effectively treat viral pneumonia in calves, and also has advantages that antibiotics cannot possess, such as being green and safe, residue-free, having few toxic side effects, low cost, convenient production, and being less likely to produce drug-resistant bacteria.

The present application belongs to the field of depression treatment, and particularly relates to the use of percussion instruments and music in the production of a device for treating depression, wherein the percussion instruments are selected from at least one of membrane-sounding instruments and body-sounding instruments, and the music is selected from at least one of fast rhythm music and slow rhythm music. The present application also relates to a device for treating depression. The steps and device of the present application can effectively treat depression, significantly relieve the symptoms of depression and anxiety of patients, and obviously improve the sleep quality of patients.

There are provided a linker compound, for which a glutathione concentration at which a disulfide bond dissociates can be designed by molecular design, and which can accurately identify a cancer cell, is stable outside a target cell, and can effectively release a drug compound in the target cell, and a complex compound containing the same. The linker compound is used for a complex compound containing a drug compound and has a structure represented by the following Formula (1). (In Formula (1), R is a compound containing hydrogen, carbon, oxygen, or a halogen element, or a derivative thereof.

The present application relates to a kind of copper-doped tricobalt tetraoxide (Cu-Co3O4) nanometer antibacterial agent and its application in the preparation of keratitis treatment product, belong to the field of biotechnology.The present application uses cobalt nitrate hexahydrate and copper nitrate trihydrate as raw material, uses isopropyl alcohol and glycerol as solvent, and successfully prepares copper-doped tricobalt tetraoxide nanometer antibacterial agent by solvothermal method.Experiment shows that under the near-infrared laser irradiation of wavelength 808nm, power density 0.5W / cm 2 , copper-doped tricobalt tetraoxide nanometer antibacterial agent has good photo-thermal, photodynamic performance and broad-spectrum antibacterial activity.In vitro experiment verifies that it can efficiently kill pathogenic bacteria, and is not prone to cause drug resistance;In vivo experiment verifies that it can effectively treat MRSA infected bacterial keratitis.The present application lays a theoretical foundation for the preparation of keratitis treatment, effective nanometer antibacterial agent and drug.

This invention discloses the application of total small molecules of Polygonatum cyrtonema in the preparation of drugs for treating vascular dementia, belonging to the field of natural medicine technology. This invention obtains total small molecules of Polygonatum cyrtonema through a combination of water extraction and alcohol precipitation with macroporous adsorption resin purification. Experiments using a rat model of vascular dementia showed that these total small molecules of Polygonatum cyrtonema effectively improved the degree of neurological function impairment and learning and memory abilities in rats, indicating that the total small molecules of Polygonatum cyrtonema prepared by this invention can effectively treat vascular dementia, providing a new drug source and treatment method for clinical vascular dementia treatment.

The invention provides a dexmedetomidine transdermal patch which comprises a backing layer, a release film and a polymer matrix layer arranged between the backing layer and the release film, the polymer matrix layer comprises dexmedetomidine, povidone and a pressure-sensitive adhesive, based on the total mass of the polymer matrix layer, the dexmedetomidine accounts for 4-10%, the povidone accounts for 5-10%, and the pressure-sensitive adhesive accounts for 5-10%. The povidone accounts for 2-12%, and the pressure-sensitive adhesive accounts for 78-94%; the pressure-sensitive adhesive comprises at least one of polymers containing carboxyl or hydroxyl functionalization.

The utility model discloses an aneurysm embolism device which comprises a micro catheter, a micro guide wire and a spring ring, the micro guide wire is inserted into a catheter cavity of the micro catheter in a penetrating mode, and the micro guide wire conveys and guides the micro catheter so as to guide the micro catheter to be inserted into an aneurysm. The spring ring is pushed into the aneurysm from a tube cavity of the micro catheter, the embolism device further comprises a flow velocity sensor used for measuring the flow velocity of blood flow in the aneurysm, and the flow velocity sensor is arranged on the micro catheter or the micro guide wire and located at the end, close to the aneurysm, of the micro catheter or the micro guide wire. According to the aneurysm embolization device, in the process of embolizing the spring ring, the blood flow speed in the aneurysm can be monitored through the flow speed sensor, so that a doctor is assisted in judging whether the spring ring needs to be continuously embolized or not and evaluating the placing effect of the spring ring, it is guaranteed that the aneurysm is effectively treated, meanwhile, excessive treatment can be reduced, and the operation accuracy is improved.

This invention belongs to the field of biomedical technology, specifically relating to the application of phyllanthin (PHY) in the preparation of drugs for the treatment or prevention of colitis. The technical problem this invention aims to solve is to provide a new option for the treatment of colitis. The technical solution of this invention is the application of phyllanthin (PHY) in the preparation of drugs for the treatment or prevention of colitis, ulcerative colitis, or Crohn's disease. This invention is applicable to the treatment or prevention of colitis, providing a treatment solution with both "anti-inflammatory" and "barrier repair" functions.

Provided are an isolated recombinant oncolytic poxvirus capable of being regulated and controlled by microRNA and a use thereof. The isolated recombinant oncolytic poxvirus can be regulated and controlled by microRNA, and the expression level of the microRNA in tumor cells of a mammal is lower than that in normal cells of the same mammal. A target sequence of the microRNA is integrated in a 3'UTR region of an E10R gene in a recombinant oncolytic poxvirus genome.

This disclosure pertains to the field of biomedicine, specifically relating to double-stranded oligonucleotides targeting the APP gene and their applications. Specifically, it provides double-stranded oligonucleotide agents or their salts, conjugates, or compositions for inhibiting amyloid precursor protein (APP) expression, wherein the double-stranded oligonucleotide agent comprises a sense strand and an antisense strand forming a double-stranded region; wherein the antisense strand sequence comprises at least 15 consecutive nucleotides of any of the sequences shown in SEQ ID NO:1-154 with a difference of no more than 3 nucleotides, and / or the sense strand sequence comprises at least 15 consecutive nucleotides of any of the sequences shown in SEQ ID NO:155-308 with a difference of no more than 3 nucleotides. The double-stranded oligonucleotide agent or its salt for inhibiting APP expression disclosed in this application can significantly inhibit APP expression and can be used for the prevention and / or treatment of diseases or conditions mediated by the APP gene and / or associated with protein amyloidosis.

This invention provides a traditional Chinese medicine compound preparation for treating vaginitis and its preparation method. The raw materials of the traditional Chinese medicine compound preparation include: 8-12 parts of Callicarpa macrophylla, 8-12 parts of Cnidium monnieri, 3-6 parts of Astragalus membranaceus, 3-6 parts of Sophora flavescens, 3-6 parts of Stemona japonica, 3-6 parts of Kochia scoparia, 3-6 parts of Saposhnikovia divaricata, and 1-2 parts of Gleditsia sinensis. The preparation method is as follows: S1, the raw materials such as Cnidium monnieri are cut into small pieces, the small pieces are expanded under high pressure, and then pulverized to obtain expanded powder; S2, the expanded powder is enzymatically hydrolyzed to obtain enzymatic hydrolysate, then glucose and peptone are added and mixed, and mixed fermentation bacteria are inoculated and cultured by shaking to obtain mixed culture solution; S3, the mixed culture solution is percolated and extracted, the percolate is collected, filtered, and concentrated to obtain compound drug, which is then used to prepare a wash or suppository to obtain the target traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation of this invention mainly uses Callicarpa macrophylla and Cnidium monnieri, and works synergistically with Astragalus membranaceus, Sophora flavescens, Stemona japonica and other raw materials to effectively inhibit pathogenic bacteria such as Staphylococcus aureus that cause vaginitis, and can also regulate the vaginal environment to effectively treat vaginitis.

The application provides application of a carbazole derivative Y16 in preparation of a drug for treating cardiovascular diseases, and belongs to the technical field of medicines.The vasodilatation activity of Y16 is determined by using a rat isolated thoracic aorta tension measurement, and the change of the vasodilatation effect of Y16 under the intervention of various channel inhibitors is observed, and the influence of Y16 on blood pressure is determined by using a rat femoral artery cannulation experiment.The results show that the carbazole derivative Y16 has a good dose-dependent vasodilatation effect, and Y16 also shows a blood pressure lowering effect, so that the carbazole derivative Y16 can effectively treat cardiovascular diseases is disclosed for the first time, the application provides a theoretical basis for obtaining a candidate compound of a drug for treating cardiovascular diseases, and also provides a new selection for a drug for treating cardiovascular diseases in clinic.

The application discloses application of ginseng glycoprotein monomer in preparation of a medicine for treating intestinal inflammation, and belongs to the technical field of biological medicine. The ginseng glycoprotein monomer extracted by the application has a molecular weight of 27kDa, a total sugar content of 65.3±2.0%, and a total protein content of 29.9±0.2%. The ginseng glycoprotein monomer can effectively treat Caco-2 cell activity reduction, cell monolayer integrity reduction and inflammatory factor release caused by DSS, and restore tight junction protein ZO-1 and Occludin expression. Therefore, the ginseng glycoprotein monomer can be used for preparing an effective medicine for treating intestinal inflammation.

The present invention relates to pharmaceutical compositions for preventing or treating pulmonary metastasis of cancer. More specifically, the present invention relates to compositions that enhance anti-cancer immunity of the lung rather than induce death of advanced cancer, thus being effective in inhibiting, preventing or treating pulmonary metastasis of cancer.

This invention relates to a novel compound and its uses. The novel compound, its isomers, its pharmaceutically acceptable salts, or its solvates have excellent binding affinity to Cerebrolysin, and therefore can effectively degrade GSPT1 through the E3 ubiquitin ligase activity of the Cerebrolysin complex, thereby enabling effective treatment of diseases including proliferative disorders.

The invention relates to the technical field of biological medicine, and particularly discloses a preparation method of a collagen and anti-propionibacterium acnes gamma protein combined preparation, and the preparation method of the collagen and anti-propionibacterium acnes gamma protein combined preparation comprises the following steps: preparing anti-propionibacterium acnes gamma protein; adding water into the anti-propionibacterium acnes gamma protein and the recombinant III-type collagen, stirring and mixing, adding glycerol and a neutralizing agent, and mixing to obtain a uniform solution; the preparation method comprises the following steps: dispersing carbomer with water, adding a preservative and a humectant, mixing, finally adding the uniform solution, and mixing to obtain the required collagen and anti-propionibacterium acnes gamma protein combined preparation. The combined preparation prepared by the method can be used for effectively treating acnes, is remarkable in curative effect, does not generate drug resistance, is short in treatment cycle, can quickly eliminate skin damage, promote cell growth and adhesion and repair skin barriers, and does not generate new rash after healing.