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13141results about How to "Effective treatment" patented technology

Method and apparatus for identifying and treating myocardial infarction

A method and apparatus for analyzing and treating internal tissues and, in particular, tissues affected by myocardial infarct. The apparatus includes a catheterized device integrating an optical probe and treatment delivery system. The probe component includes fiber optic lines that can be used in conjunction with infrared spectroscopy to analyze various characteristics of tissues, including chemical, blood, and oxygen content, in order to locate those tissues associated with myocardial infarct, to determine the best location for applying treatment, and to monitor treatment and its effects. Physically integrated with the probe component is a treatment component for delivering treatments including stem cell and gene therapy, known for having beneficial effects on tissues associated with myocardial infarct. A control system coordinates operation of the catheter, including performing chemometric analysis with the use of model data, and for providing control and visual feedback to an operator.
Owner:CORNOVA

Methods and apparatus for treating spinal stenosis

Surgical implants are configured for placement posteriorly to a spinal canal between vertebral bodies to distract the spine and enlarge the spinal canal. In the preferred embodiments the device permits spinal flexion while limiting spinal extension, thereby providing an effective treatment for treating spinal stenosis without the need for laminectomy. The invention may be used in the cervical, thoracic, or lumbar spine. Numerous embodiments are disclosed, including elongated, length-adjustable components coupled to adjacent vertebral bodies using pedicle screws. The preferred embodiments, however, teach a device configured for placement between adjacent vertebral bodies and adapted to fuse to the lamina, facet, spinous process or other posterior elements of a single vertebra. Various mechanisms, including shape, porosity, tethers, and bone-growth promoting substances may be used to enhance fusion. The tether may be a wire, cable, suture, or other single or multi-filament member. Preferably, the device forms a pseudo-joint in conjunction with the non-fused vertebra. Alternatively, the device could be fused to the caudal vertebra or both the cranial and caudal vertebrae.
Owner:NUVASIVE

Modified binding molecules comprising connecting peptides

The instant invention describes methods of separating or preferentially synthesizing dimers which are linked via at least one interchain disulfide linkage from dimers which are not linked via at least one interchain disulfide linkage from a mixture comprising the two types of polypeptide dimers. These forms can be separated from each other using hydrophobic interaction chromatography. In addition, the invention pertains to connecting peptides that result in the preferential biosynthesis of dimers that are linked via at least one interchain disulfide linkage or that are not linked via at least one interchain disulfide linkage. The invention also pertains to compositions in which a majority of the dimers are linked via at least one interchain disulfide linkage or are not linked via at least one interchain disulfide linkage. The invention still further pertains to novel binding molecules, e.g., comprising connecting peptides of the invention.
Owner:BIOGEN MA INC

Treatment of conditions through modulation of the autonomic nervous system

ActiveUS20050240241A1Decreasing and increasing parasympathetic and activityIncreasing parasympathetic activity/sympathetic activity ratioSpinal electrodesAngle modulation detailsNervous systemAnatomy
Methods are provided for treating a subject for a condition by modulating at least a portion of the subject's autonomic nervous system. In accordance with certain embodiments of the subject methods, at least a portion of a subject's autonomic nervous system is electrically or pharmacologically modulated in a manner that is effective to treat the subject for the condition. The subject methods find use in the treatment of a variety of different conditions, where such conditions include various disease conditions. Also provided are systems and kits for use in practicing the subject methods.
Owner:PALO ALTO INVESTORS

Compression device with compression measuring system

InactiveUS6338723B1Prediction is accurate and reliableAccurately and reliably and measure compression levelFeet bandagesAbsorbent padsCompression deviceEngineering
A device is provided for compression of objects such as parts of the body. The device has the form of a band that can be shaped like a sleeve, wrap or garment that is sized to encircle the body part or other compressible object and having a component or components made of an elastic material. Indicia such as tick marks or scales are printed on the device. The stretch of the elastic material as the device is tensioned around the body part causes increased separation of the indicia or movement of a free end of the band with respect to the indicia. A system measures the separation of the indicia and converts it to compression as a function of the circumference of the body part. The system may be a card having edges with measurement scales or the scales may be printed on the device and the displacement of a free end of a band or sub-band of the device with respect to the scales indicates the compression for particular circumferences of the body part. The device may have additional scales printed on it for measuring the circumference of the body part.
Owner:MEDI MFG INC

Hepatitis C virus inhibitors

Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description.Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
Owner:BRISTOL MYERS SQUIBB CO

RNA interference for the treatment of heart failure

InactiveUS8404658B2Reduce expressionDecreasing ventricular arrhythmiasOrganic active ingredientsTissue culturePhospholambanTransfection
The present invention relates to targeted RNAi for the treatment of heart failure by modulating defective cardiac Ca2+ homeostasis via decreasing expression or activity of phospholamban (PLB) using adeno-associated virus (AAV) transfection of cardiomyocytes. Methods for decreasing ventricular arrhythmias, as well as methods for overall improvement of survival from heart failure in subjects are also disclosed. Further, the present invention provides methods which can be used to diagnose susceptibility to treatment by RNAi, and includes pharmaceutical compositions, kits and vectors including an RNAi sequence.
Owner:NANOCOR THERAPEUTICS +1

Ventilation interface for sleep apnea therapy

The ventilation interface for sleep apnea therapy interfaces a ventilation device to the patient's airways. The ventilation interface includes a pair of nasal inserts made from flexible, resilient silicone which are oval shaped in cross-section and slightly tapered from a base proximal the ventilation supply to the distal tip end. A bead flange is disposed about the exterior of each insert at the distal end of the insert. In one embodiment, a valve is disposed between the nasal inserts and a source of positive airway pressure, the valve having a rim with a one-way diaphragm pivotally attached to the valve body with an inflatable bladder depending from the rim which seals against an exit port during inspiration and deflates to uncover the exit port on expiration. Another embodiment has nasal inserts without positive airway pressure but with a removable filter in the inserts for filtering inspired air.
Owner:SALTER LABS LLC

Intravascular devices and fibrosis-inducing agents

InactiveUS20050149173A1Reducing perigraft leakageFacilitate “anchoring”StentsPeptide/protein ingredientsFibrosisCoil embolization
Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.
Owner:ANGIOTECH INT AG (CH)

Integrated sleep diagnostic and therapeutic system and method

ActiveUS7942824B1Effective treatmentEasy to useMedical devicesCatheterSleep Disorder TherapyApnea
The present invention relates to an integrated sleep diagnosis and treatment device, and more particularly to an integrated apnea diagnosis and treatment device. The present invention additionally relates to methods of sleep diagnosis and treatment. The sleep disorder treatment system of the present invention can use a diagnosis device to perform various forms of analysis to determine or diagnose a subject's sleeping disorder or symptoms of a subject's sleep disorder, and using this analysis or diagnosis can with or in some embodiments without human intervention treat the subject either physically or chemically to improve the sleeping disorder or the symptoms of the sleeping disorder. The diagnostic part of the system can use many different types of sensors and methods for diagnosing the severity of the symptoms of or the sleep disorder itself. The treatment part of the system can use a device to physically or chemically treat the subject's symptoms or sleep disorder itself.
Owner:CLEVELAND MEDICAL DEVICES

Method and apparatus for treating vascular obstructions

Method and device for treating vascular obstruction using ultrasonic energy in combination with cryogenic energy and / or an expandable member is disclosed. Ultrasound energy is delivered from a specially designed ultrasound transducer that is inserted in a blood vessel. Ultrasound energy can be delivered in conjunction with cryogenic energy. Ultrasound energy can also be delivered in conjunction with an expandable member such as expandable tubing, a hinged transducer, or a balloon. Ultrasound energy can also be delivered in conjunction with both cryogenic energy and an expandable member. The use of ultrasound energy in combination with cryogenic energy and / or an expandable member can treat a vascular obstruction.
Owner:BABAEV EILAZ

Antibodies with altered effector functions

InactiveUS20050152894A1Good curative effectEffectively treating said mammalAntibacterial agentsSenses disorderDiseaseEffector functions
The invention provides antibodies with altered effector functions, and methods of using these antibodies in the treatment of various diseases. The invention further provides compositions, kits and articles of manufacture for practicing methods of the invention.
Owner:GENENTECH INC

Topical formulations and methods of use

A topical composition comprising a lipoic acid, a carnitine, and a carnosine in a suitable vehicle for topical application and a method for treating skin is provided. The present compositions are useful in improving the appearance of aged skin characterized by wrinkles and loss of elasticity. Preferred components include R-lipoic acid or R-dihydrolipoic acid, acetyl-1-carnitine, and 1-carnosine.
Owner:TRACIE MARTYN INT

Treatment system for flat substrates

A reactor for the treatment of flat substrates includes a vacuum chamber with a process space arranged therein. A first electrode and a counterelectrode generate a plasma for the treatment of a surface to be treated and form two opposite walls of the process space. The reactor further includes means for introducing and means for removing gaseous material into and out from the process space. At least one substrate is accommodated by a front side of the counterelectrode. The vacuum chamber includes an opening having a closure device. The reactor includes a device for varying the relative distance between the first electrode and the counterelectrode and a device assigned to the counterelectrode for accommodating substrates. At least one substrate is arranged at an angle alpha in a range of between 0° and 90° relative to a perpendicular direction at least during the performance of the treatment.
Owner:LEYBOLD OPTICS

Devices and Methods for Treatment of Skin Conditions

Devices and methods for the treatment of skin conditions and lesions are disclosed herein. A compact hand held device that can be safely used by those suffering from skin conditions, such as acne, warts, cold blisters, blemished skin, or fine wrinkles. The devices employ the application of ultrasound energy and heat for the treatment of skin conditions and lesions. Typically, the peak temperatures employed are about 40° C. to about 70° C. by the devices, are achieved in less than about 20 second, and maintained for less than about 40 second. Ultrasound absorption and thermal conduction transfers heat from the device to the skin and causes a biological response that accelerates acne clearing, treats blemished skin, itching, or fine wrinkles. The total heat transferred is low enough to prevent burns.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Ethmoidotomy System and Implantable Spacer Devices Having Therapeutic Substance Delivery Capability for Treatment of Paranasal Sinusitis

Substance delivering spacer devices may comprise expandable reservoirs that are implantable in paranasal sinuses and other cavities, openings and passageways of the body to maintain patency and to provide sustained local delivery of a therapeutic or diagnostic substance. Also provided are sinus penetrator devices and systems for performing ethmoidotomy procedures or for creating other openings in the walls of paranasal sinuses or other anatomical structures.
Owner:ACCLARENT INC

SUBSTITUTED SPIROPYRIDO[1,2-a]PYRAZINE DERIVATIVE AND PHARMACEUTICAL USE OF SAME AS HIV INTEGRASE INHIBITOR

[Summary][Problem] Provided is a substituted spiropyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, which is useful as an anti-HIV agent.[Solving Means] The present invention relates to a compound represented by the following formula [I] or [II] or a pharmaceutically acceptable salt thereof:wherein each symbol is as defined in the specification.
Owner:JAPAN TOBACCO INC

Omega-3 fatty acids and dyslipidemic agent for lipid therapy

A method and composition for blood lipid therapy by administering to the subject an effective amount of a dyslipidemic agent and omega-3 fatty acids. The method utilizes a single administration or a unit dosage of a combination of dyslipidemic agent and omega-3 fatty acids for the treatment of patients with hypertriglyceridemia, hypercholesterolemia, mixed dyslipidemia, coronary heart disease (CHD), vascular disease, artherosclerotic disease and related conditions, and the prevention or reduction of cardiovascular and vascular events.
Owner:RELIANT PHARMACEUTICALS INC +1

Ventilation interface for sleep apnea therapy

The ventilation interface for sleep apnea therapy interfaces a ventilation device to the patient's airways. The ventilation interface includes a pair of nasal inserts made from flexible, resilient silicone which are oval shaped in cross-section and slightly tapered from a base proximal the ventilation supply to the distal tip end. A bead flange is disposed about the exterior of each insert at the distal end of the insert. A bleed port for release of exhaled air is defined through a conical vent projecting normally to the path of the incoming air flow, and continues through a nipple extending to the exterior of the air conduit. In one embodiment, a pair of nasal inserts are integral with a nasal cannula body, with bleed ports axially aligned with each insert. In another embodiment, each insert is independently connected to a separate, thin-walled, flexible supply line.
Owner:WOOD THOMAS J

System and method for treating biological tissue with a plasma gas discharge

Devices and methods for treating biological tissue using a plasma gas-discharge are disclosed herein. An electrode for igniting a gas flow to form a plasma gas-discharge, wherein the electrode is configured within the device such that upon encountering a surface of the biological tissue by the electrode, a path of current from the electrode to the surface of the biological tissue is formed, thereby igniting the gas flow and forming the plasma gas-discharge. In some embodiments, electromagnetic interactions between the treated biological tissue and the plasma gas discharge traversing the electromagnetic interaction gap shape the profile of the plasma gas discharge. According to some embodiments, the device includes an electrode for igniting gas of the gas flow, and electromagnetic interactions between the electrode and the skin determine, at least in part, the electromagnetic interactions that shape the profile of the plasma gas discharge. In some embodiments, the device further includes a housing for providing support for the electrode, wherein the electrode is disposed relative to the housing such that the electrode is substantially electrically unshielded by the housing, and the electrode is positioned to electromagnetically interact with a surface of the biological tissue to shape, at least in part, the plasma profile. According to some embodiments, the presently disclosed device includes a dual-purpose nozzle-electrode for gas delivery and for igniting the gas flow. A method of transdermal ion delivery of a plasma flux to biological tissue as a means of treating the biological tissue is also provided.
Owner:ALMA LASERS LTD

Techniques to treat neurological disorders by attenuating the production of pro-inflammatory mediators

Methods and devices to attenuate tumor necrosis factor (TNF) and other pro-inflammatory mediators in the CNS to treat neurological, neurodegenerative, neuropsychiatric disorders, pain and brain injury are described. More particularly, TNF blocking agents that target intracellular signals and downstream effects associated with the production and secretion of TNF are described. Devices described include therapy delivery devices comprising a reservoir capable of housing a TNF blocking agent and a catheter operably coupled to the device and adapted to deliver the TNF blocking agent to a target site within a subject.
Owner:WARSAW ORTHOPEDIC INC +1

Intravascular devices and fibrosis-inducing agents

InactiveUS20050149175A1Reducing perigraft leakageFacilitate “anchoring”StentsPeptide/protein ingredientsFibrosisCoil embolization
Intravascular devices (e.g., stents, stent grafts, covered stents, aneurysm coils, embolic agents and drug delivery catheters and balloons) are used in combination with fibrosing agents in order to induce fibrosis that may otherwise not occur when the implant is placed within an animal or to promote fibrosis betweent the devices and the host tissues. Compositions and methods are described for use in the treatment of aneurysms and unstable arterial (vulnerable) plaque.
Owner:ANGIOTECH INT AG (CH)

System and method for electronically managing medical information

InactiveUS20020138306A1Reduce stepsReduces liability costOffice automationSpecial data processing applicationsMedical recordOccupational medicine
An online occupational medicine management system and method that allow authorized physicians, patients, employers, and insurance companies to capture, store, retrieve, and disseminate an employee's medical records from any computer having Internet access. The employee medical information can be shared between the aforementioned parties in real time, resulting in improved quality of care and greater efficiency in the field of work-related injuries, i.e., workers' compensation. The online occupational medicine management system also provides physicians with diagnosis appropriate treatment protocols that can be pre-approved by a patient's employer and / or the employer's insurance company, thus requiring monitoring only of medical treatments that fall outside of the pre-approved protocols. Accordingly, administrative costs to insurance companies and employers are lessened, and payment time to physicians is reduced.
Owner:SABOVICH JOHN

Topical nitric oxide donor compositions

InactiveUS6287601B1Reduced and failing organ functionPoor appetitePowder deliveryBiocideLipid formationEquine Species
Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID mixed in a lipid-based carrier are described. The application of such combinations to the affected areas, e.g., the hoofs and surrounding tissues, of an equine afflicted with laminitis provides relief from the debilitating effects of this painful, often life-threatening condition.
Owner:STREHKEHN INT LTD
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