18 results about "Bypass surgery" patented technology

The invention relates to the field of medical instruments and public health, in particular to an artificial blood vessel with anticoagulation, endothelium promotion and bending resistance functions and a preparation method of the artificial blood vessel, and the artificial blood vessel is used for various blood vessel replacement and blood vessel bypass operations and has the characteristics of anticoagulation, endothelium promotion and bending resistance. The copper-containing material and the degradable magnesium-based metal material are respectively integrated on the inner surface of the artificial blood vessel and in the interlayer of the vessel wall, so that the functions of anticoagulation, endothelium promotion and bending resistance of the artificial blood vessel are realized. According to the artificial blood vessel with the anticoagulation, endothelium promotion and bending resistance functions, in the initial stage of use, due to the spiral structure of the magnesium alloy wire, the blood vessel cannot collapse after being bent, the blood flow is kept smooth, copper ions, magnesium ions and a small amount of hydrogen can be released to surrounding tissues in the use process, the microenvironment of the surrounding tissues is adjusted to be alkalescent, and the blood circulation is kept smooth. Through the synergistic effect of the copper ions and the magnesium alloy, the effects of promoting endothelialization, resisting blood coagulation and adjusting the acid-base property of the microenvironment are achieved at the same time, and therefore the functions of resisting blood coagulation, promoting endothelium and resisting bending are achieved.

The invention discloses a proximal anastomosis auxiliary device in coronary artery bypass grafting, and relates to the technical field of medical instruments. Comprising a puncture needle, a puncture cannula and an annular compressor. The puncture needle is sleeved with the puncture cannula, and a bulged ball is arranged at the head end of the puncture cannula; the annular compressor is arranged outside the puncture cannula in a sleeving mode and can slide in the axial direction, a compression ring with a notch is arranged at the head end of the annular compressor, and the inner diameter of the compression ring is smaller than the outer diameter of the bulging ball. During puncture, the annular compressor is pressed down after puncture enters the aorta, and the compression ring and the bulging ball cooperate to clamp and close a puncture point to achieve blood-free operation; after the aorta wall in the compression ring is cut off, the bridge vessel is matched with the aorta, and the suture passes through the compression ring together; after suturing is completed, the annular compressor is rotated, the suture retreats from the notch, the suture is tightened and knotted after the whole device is withdrawn, and anastomosis is completed. The aorta forceps clip operation is avoided, the plaque falling risk is eliminated, anastomosis can be completed only through a single hole, operation is easy and convenient, hemostasis is reliable, and cost is low.

The present invention involves a novel method of reducing the risk of developing atrial fibrillation (AF) and / or atrial flutter (AFL) post coronary bypass surgery (CABS) by administering, to patients who have undergone CABS, loading and maintenance doses of dofetilide intravenously followed by oral doses.

The present article relates to an artificial graft (artificial blood vessel) used in surgical procedures such as bypass surgery (such as implantation of an artificial blood vessel).

The application belongs to the technical field of biological medicine, and particularly relates to a pharmaceutical use of a Hedgehog pathway inhibitor in preventing and treating vascular remodeling and restenosis after an arterial bypass operation and improving the survival rate of a coronary heart disease patient after the arterial bypass operation. The abnormal proliferation of smooth muscle cells driven by endothelial cell activation can be obviously inhibited by the Hedgehog pathway inhibitor GDC-0449 intervention, and the inflammatory reaction can be effectively reduced. In the in-vivo experiment, the local application of GDC-0449 to the bypass artery can significantly relieve the remodeling and stenosis of the bypass artery, and provide a theoretical basis and strong support for the molecular targeted treatment strategy of the vascular remodeling and failure after the arterial bypass operation.

A powder formulation for preserving tissue and organ function, and more particularly to shelf stable powder formulations that can be reconstituted at point of use, including during a fat grafting process, coronary artery bypass graft surgery, and peripheral bypass surgery, or other grafting / transplant surgery prior to or during the medical procedure to preserve the tissues / organs used in these procedures. The powder formulation includes a reducing agent; an antioxidant; a sugar; a nitric oxide substrate; a buffering agent; and physically acceptable salt. Also provided are a method of preparing an organ or tissue preservation solution by reconstituting the powder formulation, and a method of preserving tissue or an organ using same.

The present invention involves novel safe dosage regimens comprising the administration of a loading and maintenance dose of dofetilide iv, followed by oral dosing of dofetilide. Methods include (a) reducing the risk of developing atrial fibrillation (AF) and / or atrial flutter (AFL) post coronary bypass surgery (CABS); (b) terminating arrhythmic storm in patients following implementation of an implantable defibrillator by administrating loading and maintenance infusions of dofetilide intravenously followed by oral dosing; and, (c) converting atrial fibrillation (AF) or atrial flutter (AFL) in a patient presenting with highly symptomatic AF or AFL.

A method for reducing a composite endpoint risk of myocardial infarction (MI), stroke, coronary revascularization, unstable angina requiring hospitalization, cardiac arrest, and cardiovascular death in a subject including administering, orally once per day to the subject, a composition comprising about 0.5 total mg of (i) colchicine, (ii) a pharmaceutically acceptable salt of (i), or any combination of (i) and (ii), wherein the patient has at least one history of diabetes, a past myocardial infarction, an unstable angina, a coronary bypass surgery, and a coronary angioplasty; wherein the patient is also administered a daily dose of statin therapy; and wherein the composite endpoint risk in the subject is reduced relative to a dosing regimen where the patient receives standard secondary prevention therapy of a statin.

The invention relates to the technical field of surgery planning, in particular to a minimally invasive bypass surgery planning method based on multi-modal image fusion, which comprises the following steps: acquiring heart dynamic parameters; generating a dynamic three-dimensional model; calculating a blockage risk score, and determining an initial anastomosis angle of the bridge blood vessel and the target blood vessel according to the blockage risk score; determining the fluctuation range of the matching angle; acquiring the variation range of the eddy current intensity value, judging whether the matching angle meets the requirement or not, and correcting the matching angle in response to the inconformity of the requirement; and determining the anastomosis position of the bridge blood vessel and outputting an operation planning scheme. According to the method, the blockage risk of the bridge blood vessel is quantified by combining the past medical history and blood routine parameters in the medical record of the patient to obtain the blockage risk score, the corresponding anastomosis angle is determined according to the blockage risk score, and the anastomosis angle is corrected according to the vortex intensity value; therefore, the accuracy of the minimally invasive surgery is improved, and the risk of blockage of the bridge blood vessel after the surgery is reduced.

The present article relates to an artificial graft (artificial blood vessel) used in surgical procedures such as bypass surgery (such as implantation of an artificial blood vessel).

A method for reducing a composite endpoint risk of myocardial infarction (MI), stroke, coronary revascularization, unstable angina requiring hospitalization, cardiac arrest, and cardiovascular death in a subject including administering, orally once per day to the subject, a composition comprising about 0.5 total mg of (i) colchicine, (ii) a pharmaceutically acceptable salt of (i), or any combination of (i) and (ii), wherein the patient has at least one history of diabetes, a past myocardial infarction, an unstable angina, a coronary bypass surgery, and a coronary angioplasty; wherein the patient is also administered a daily dose of statin therapy; and wherein the composite endpoint risk in the subject is reduced relative to a dosing regimen where the patient receives standard secondary prevention therapy of a statin.

The invention relates to the technical field of medical instruments, in particular to a coronary artery bypass postoperative rehabilitation training device which comprises a bottom frame, supporting rods, a top frame, a seat plate and a back plate, the supporting rods are arranged at the top end of the bottom frame, the top ends of the supporting rods are connected with the bottom end of the top frame, and the seat plate is fixedly installed at the top end of the top frame. The back plate is fixedly installed on the rear side of the top end of the seat plate, the lifting assemblies are fixedly connected with the supporting rod and the top frame, the training assemblies are installed on the lifting assemblies, the handrail assemblies are arranged on the left side and the right side of the top frame respectively, and the lifting assemblies are fixedly connected with the supporting rod and the top frame. The training assembly is used for actively and passively exercising quadriceps femoris muscles of a patient; through an active training mode and a passive training mode, rehabilitation training of a patient is achieved, and flexibility is improved.

The invention belongs to the technical field of cardiac surgery instruments, and particularly relates to a suction device applied to coronary artery bypass surgery, which comprises a nursing trolley, a first placing plate is fixedly mounted at the lower end of the nursing trolley, a second placing plate is fixedly mounted at the upper end of the nursing trolley, and the first placing plate and the second placing plate are arranged in parallel up and down; four groups of universal wheels are fixedly mounted at the lower end of the nursing trolley, protective side plates are fixedly mounted on the front side, the rear side, the left side and the right side of a first placement plate at the lower end of the nursing trolley, and a negative pressure pump is fixedly mounted on the upper side of the right end of the first placement plate; through mutual cooperation of a negative pressure pump, a main pipeline, a blood storage tank, a tank cover and a branch pipe, a bent pipe suction head, a straight pipe suction head and a thin pipe suction head in a storage box are connected with a connector for replacement, then blood at a wound surface is sucked in the operation process, and the blood is absorbed and stored through the blood storage tank; and an undefined operation field caused by blood flow is avoided.

A method for reducing a composite endpoint risk of myocardial infarction (MI), stroke, coronary revascularization, unstable angina requiring hospitalization, cardiac arrest, and cardiovascular death in a subject including administering, orally once per day to the subject, a composition comprising about 0.5 total mg of (i) colchicine, (ii) a pharmaceutically acceptable salt of (i), or any combination of (i) and (ii), wherein the patient has at least one history of diabetes, a past myocardial infarction, an unstable angina, a coronary bypass surgery, and a coronary angioplasty; wherein the patient is also administered a daily dose of statin therapy; and wherein the composite endpoint risk in the subject is reduced relative to a dosing regimen where the patient receives standard secondary prevention therapy of a statin.

The utility model relates to medical instrument technical field discloses heart bypass operation blood vessel fixing clamp, including the clamping plate, the inner wall sliding connection has rubber block in the clamping plate, the right side of clamping plate is provided with locking mechanism, locking mechanism is used for fixing clamping plate, avoids the loosening in clamping process, the front side of clamping plate is provided with replacement mechanism, replacement mechanism is used for replacement processing according to different size blood vessel, the locking mechanism includes the rack, the left end fixed connection in the inner wall left side of clamping plate of rack, the right side intercommunication of clamping plate has fixed box. In the utility model, through pressing clamping plate to blood vessel and clamping, at this time rubber block follows clamping plate and bends, simultaneously, the right end of rack passes through clamping plate and is connected in fixed box in sliding, through the pushing force of spring one under the top post, makes extrusion force act on rack, makes the close engagement of rack and tooth groove, realizes the locking processing of clamping plate.

The invention relates to the technical field of cardiac surgery, and particularly discloses a heart suspension mechanism and a using method thereof.The heart suspension mechanism comprises two connecting plates, and the opposite sides of the two connecting plates are connected with a plurality of first connecting belts; according to the heart suspension mechanism, through careful design and cooperative cooperation of all the components, in the fixing and suspension process of the heart and the cardiothoracic part, the end, away from the winding roller, of the suspension rope is connected to the heart stabilizer, and by means of the length adjusting effect of the suspension rope, a worker can adjust the suspension height and angle of the hearts of different patients, so that the heart suspension efficiency is improved. A more efficient, safer and more convenient fixing and hanging solution is provided for cardiac surgery and rehabilitation treatment, meanwhile, the device is suitable for bypass surgery with the requirement for the heart position, the surgery field is exposed, the risks of cardiac adventitia injury and cardiac rupture are reduced, the surgery difficulty of the bypass surgery of old patients is reduced, and the patient experience is improved. The risk of complications caused by the heart fixator in the operation is reduced, and the bypass operation is convenient to popularize.

The present invention relates to a novel bio-ink for preparing bioartificial vascular grafts which are highly useful for vascular and cardiovascular research and therapy, and in particular for surgical vascular and cardiovascular repair and bypass surgery. The bio-ink composition of the invention comprises a peptide-grafted alginate and smooth muscle cells, endothelial cells or cells which are capable of developing into endothelial cells. According to the invention, the peptides grafted onto the alginate are derived from an extracellular matrix protein or mimic such proteins. The invention also relates to a method for manufacturing a bioartificial vascular graft comprising the printing of the bio-ink composition of the invention. Bioartificial vascular grafts, which are obtainable by the method of the invention, are also encompassed by the invention. In yet another aspect, the invention relates to the use of the bio-ink for in vitro drug screening and as an in-vitro training model for endovascular or surgical training.