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Polymeric delivery devices have been developed which combine high loading / high density of molecules to be delivered with the option of targeting. As used herein, “high density” refers to microparticles having a high density of ligands or coupling agents, which is in the range of 1000-10,000,000, more preferably between 10,000 and 1,000,000 ligands per square micron of microparticle surface area. A general method for incorporating molecules into the surface of biocompatible polymers using materials with an HLB of less than 10, more preferably less than 5, such as fatty acids, has been developed. Because of its ease, generality and flexibility, this method has widespread utility in modifying the surface of polymeric materials for applications in drug delivery and tissue engineering, as well other other fields. Targeted polymeric microparticles have also been developed which encapsulate therapeutic compounds such as drugs, cellular materials or components, and antigens, and have targeting ligands directly bound to the microparticle surface. Preferred applications include use in tissue engineering matrices, wound dressings, bone repair or regeneration materials, and other applications where the microparticles are retained at the site of application or implantation. Another preferred application is in the use of microparticles to deliver anti-proliferative agents to the lining of blood vessels following angioplasty, transplantation or bypass surgery to prevent or decrease restenosis, and in cancer therapy. In still another application, the microparticles are used to treat or prevent macular degeneration when administered to the eye, where agents such as complement inhibitors are administered.

A portable cooler having one or more ice sheets including built-in refrigerant cubes. The cooler comprises an outer fabric shell and one or more sets of spaced apart refrigerant cubes encapsulated in plastic to form ice sheets that are attached to the interior walls of the cooler. The walls of the cooler may also include one or more layers of thermal insulation. The ice sheets provide a visually pleasing appearance to the inside of the cooler suggestive of cooling effects. The ice sheets may be retained along the walls of the cooler by seams sewn along the lanes passing between the refrigerant cubes, by being retained in pockets formed by sidewall liners or by being secured into chambers defined by the cooler's outer walls and a plastic insert fitted into the cooler. The cooler may include a hinged top and bottom that can be folded flat for allowing the cooler to assume a compact configuration during storage or freezing of the refrigerant cubes.

PCT No. PCT / US96 / 20932 Sec. 371 Date Jun. 30, 1998 Sec. 102(e) Date Jun. 30, 1998 PCT Filed Dec. 23, 1996 PCT Pub. No. WO97 / 25085 PCT Pub. Date Jul. 17, 1997The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

A composition in the form of a chewing gum composition or a confectionery composition containing a stain removing complex of a stain removing agent and a cyclodextrin compound and methods of preparing and using the same to remove stains from dental material including teeth.

A portable cooler having one or more ice sheets including built-in refrigerant cubes. The cooler comprises an outer fabric shell and one or more sets of spaced apart refrigerant cubes encapsulated in plastic to form ice sheets that are attached to the interior walls of the cooler. The walls of the cooler may also include one or more layers of thermal insulation. The ice sheets provide a visually pleasing appearance to the inside of the cooler suggestive of cooling effects. The ice sheets may be retained along the walls of the cooler by seams sewn along the lanes passing between the refrigerant cubes, by being retained in pockets formed by sidewall liners or by being secured into chambers defined by the cooler's outer walls and a plastic insert fitted into the cooler. The cooler may include a hinged top and bottom that can be folded flat for allowing the cooler to assume a compact configuration during storage or freezing of the refrigerant cubes.

A unit dose medication compliance monitoring and reporting apparatus and system that includes a dispenser shell formed with dose compartments. A retainer sheet affixed to the shell seals each compartment and partially bursts upon dispensing. A sensor network and monitoring and reporting circuitry records dispensing times and determines an average time interval, which can be reported with other data on an integral data display. The system can thereby monitor and report patient compliance with prescription regimens. Additional data can be recorded and displayed for augmented patient compliance assistance and analysis, which data can include customized informational messages, telephone and other patient support contact information, unit doses dispensed and remaining, reminder alarms, identification data, prescription regimens, among other data. In myriad variations and alternative preferred configurations, the devices and systems have demonstrated efficacy in minimalist to complex monitoring and reporting applications ranging from routine prescription monitoring to detailed clinical trial assessments.

The present invention comprises a golf club head comprising a body having a crown, a sole, a front wall and a hosel, wherein the body defines a hollow interior. The golf club head further comprises a center of gravity adjustment assembly wherein the center of gravity adjustment assembly is positioned within the hollow interior of the body, and allows the center of gravity of the golf club head to be adjusted by at least 0.050 inch, preferably along a vertical axis.

The present invention provides polypeptides having a nucleotide polymerase activity and method of enhancing polymerase activity. The polypeptides of the present invention may posses both a DNA-dependent DNA polymerase activity and an RNA-dependent DNA polymerase activity, i.e., a reverse transcriptase activity. The polypeptides of the present invention may be used in any application including, but not limited to, DNA sequencing reactions, amplification reactions, cDNA synthesis reactions, and combined cDNA synthesis and amplification reactions, e.g., RT-PCR.

An optical and / or optoelectrical transceiver and system are disclosed that enable parallel transmission of data and management signals via an optical fiber without affecting data signal transmissions transmitted on the optical fiber. Furthermore, the present transceiver and system provide a fault diagnosis function for an optical fiber link. The transceiver and system generally comprise an interface, an intersecting transmission management unit, a driver, a management signal driving unit, an optical transmitter, an optical receiver, an amplifier, a management signal recovery unit, a management unit, and optionally, a power supply unit.

A distributed historian framework is provided where historical data is collected in accordance with an organizational model of a hierarchical system that is distributed across various elements of an enterprise. A directory service operates with the organizational model to enable configuration of historian components within the organization and to enable data to be located within the organization. In one aspect, an industrial automation system is provided. The system includes at least one historian component to archive data within an organization. A common data model then exposes functionality and data of the organization to the historian component.

A co-current contacting system is described herein. The co-current contacting system includes a co-current contactor located in-line within a pipe. The co-current contactor includes an annular support ring configured to maintain the co-current contactor within the pipe and a number of radial blades configured to allow a liquid stream to flow into the co-current contactor. The co-current contacts also includes a central gas entry cone configured to allow a gas stream to flow through a hollow section within the co-current contactor, wherein the co-current contactor provides for efficient incorporation of liquid droplets formed from the liquid stream into the gas stream. The co-current contacting system also includes a separation system configured to remove the liquid droplets from the gas stream.

A long, well tool which effectively performs as an integral part of a typical coiled tubing string and accordingly can be ran continuously into a pressurized wellbore with the same deployment equipment as used with known coiled tubing. The tool is comprised of a plurality of elements (e.g. perforating charges or logging sensors such as hydrophones, geophones, gamma ray sensors, gravity sensors, etc.) fixed at spaced, known distances from each other within a flexible housing, e.g. a length of coiled tubing.

A customizable golf club head is disclosed herein. The customizable golf club head includes a face component having a face and a flange, a crown-plate attached to the flange, a sole-plate attached to the flange, a skid-plate attached to the sole-plate, a swing-weight member, and a plurality of removable weight members with each of the plurality of weight members positioned within a pocket of the plurality of pockets.

A heat transfer system includes a power sub-system configured to receive a heat source stream, and one or more heat exchangers configured to transfer heat from the heat source stream to a working stream. The working stream is ultimately heated to a point where it can be passed through one or more turbines, to generate power, while the heat source stream is cooled to a low temperature tail. A distillation condensation sub-system cools the spent stream to generate an intermediate stream and a working stream. The working stream can be variably heated by the intermediate stream so that it is at a sufficient temperature to make efficient use of the low temperature tail. The working stream is then heated by the low temperature tail, and subsequently passed on for use in the power sub-system.

The invention discloses a PDF form extraction method. According to the technical scheme, the method comprises the steps of analyzing a PDF document by a page number to obtain all image data, first line data and character data, processing the image data in sequence according to the page number by adopting an image identification algorithm, and obtaining second line data corresponding to form data from the image data with the form data; processing the first line data and the second line data in sequence according to the page number by adopting a graphic algorithm, thereby obtaining form frame data with form row data and column data; performing clustering processing on the character data by adopting a clustering algorithm to obtain text data with a character string set; and obtaining all the form data in the PDF document through final all form frames and all text data. According to the method for extracting forms in the PDF document, the accuracy and efficiency of extracting the forms in the PDF document are improved, and more accurate form data can be obtained; and the method is suitable for the field with higher requirements on the accuracy and efficiency of extracting the form data.

A portable cooler having one or more ice sheets including built-in refrigerant cubes. The cooler comprises an outer fabric shell and one or more sets of spaced apart refrigerant cubes encapsulated in plastic to form ice sheets that are attached to the interior walls of the cooler. The walls of the cooler may also include one or more layers of thermal insulation. The ice sheets provide a visually pleasing appearance to the inside of the cooler suggestive of cooling effects. The ice sheets may be retained along the walls of the cooler by seams sewn along the lanes passing between the refrigerant cubes, by being retained in pockets formed by sidewall liners or be being secured into chambers defined by the cooler's outer walls and a plastic insert fitted into the cooler.

A controlled database system is designed for rapid access of data records with reduced memory storage requirements. The database system employs a set of obfuscated data records stored in data crystals that can only be accessed and read by an iterator, which is not directly accessible by the users of the database. The iterator accesses information responsive to a predefined query sent from a customer application. Rather than providing general tools to customers for constructing any possible queries, such as is done in structured query language database systems, database systems embodying the present invention allow only predefined types of queries to be used by customer applications. By restricting the types of queries customer applications can call, valuable data records remain secure from unauthorized reconstruction or duplication while still allowing limited access for specific purposes.

An electrode-forming composition for providing an activated carbon electrode for an electric double layer capacitor is provide by blending activated carbon, a vinylidene fluoride polymer and a solvent including a plasticizer in addition to a good solvent for the vinylidene fluoride polymer. By applying the electrode-forming composition onto an electroconductive substrate, and selectively removing the solvent preferably by a combination of extraction of the plasticizer with a poor solvent for the vinylidene-fluoride polymer and evaporation of the solvent, it is possible to obtain an activated carbon electrode (polarizable electrode) that has an activated carbon electrode layer exhibiting good adhesion onto the electroconductive substrate and a good flexibility, and therefore has good processability. By using the activated carbon electrodes as polarizable electrodes, it is possible to provide an electric double layer capacitor having improved reliability.

The present invention provides mutant DNA polymerases, polynucleotides encoding the polymerases, cassettes and vectors including such polynucleotides, and cells containing the polymerases, polynucleotides, cassettes, and / or vectors of the invention. The present invention also provides methods for synthesizing polynucleotides and kits including a DNA polymerase of the invention.

A customizable golf club head is disclosed herein. The customizable golf club head includes a body comprising a crown and a sole and a removable skid plate attached to the sole, wherein the removable skid plate affects the face angle of the golf club head at address. The face angle of the golf club can be further altered by removing the first skid plate and replacing it with a second skid plate having a structure that, when the second skid plate is affixed to the golf club head, causes the golf club head to have a different face angle at address.

A unit dose medication compliance monitoring and reporting apparatus and system (100) that includes a dispenser shell (120) formed with dose compartments (130). A retainer sheet (150) affixed to the shell (120) seals each compartment (130) and partially bursts upon dispensing. A sensor network and monitoring and reporting circuitry (160, 170) records dispensing times and determines an average time interval, which can be reported with other data on an integral data display (190). The system (100) can thereby monitor and report patient compliance with prescription regimens. Additional data can be recorded and displayed for augmented patient compliance assistance and analysis, which data can include customized informational messages, telephone and other patient support contact information, unit doses dispensed and remaining, reminder alarms, identification data, prescription regimens, among other data. In myriad variations and alternative preferred configurations, the devices and systems have demonstrated efficacy in minimalist to complex monitoring and reporting applications ranging from routine prescription monitoring to detailed clinical trial assessments.

The invention provides an audio and video combined teaching and training system and a realization method. Belonging to the teaching instrument field, the invention relates to a training system applied to teaching and the using method of the system. The system mainly includes: a teacher's audio and video recording device consisting of a teacher camera and a teacher adapter; a student's audio and video recording device consisting of a student camera and a student adaptor; an ID identifier for identifying the ID of personnel; a host including a memorizer for storing data and operating programs, and a processor as well as a display. The invention has the advantages that by the invention, users can comprehensively record information in teaching, effectively combine various data flows, and display the process and details of teaching to improve the teaching effect.

The invention discloses a method for storing transmission line integrated data based on HBase. The method comprises the steps of collecting the transmission line integrated data, wherein the transmission line integrated data comprise structural data and unstructured data; classifying the transmission line integrated data; building an Hbase table according to the classifying result; converting the transmission line integrated data in the Hbase table as byte arrays; sequentially storing the byte arrays into an HBase distributed database according to the format of the Hbase table, wherein the HBase distributed database is built on an HDFS (Hadoop Distributed File System). By adopting the method, the transmission line integrated data can be integrated with the HDFS and HBase; the problems that the original data are poor in information sharing, the information is in isolated island, and the unstructured data are difficult to process can be solved.

A method for making a layered material can include providing a substrate having a surface with at least one region having a charge and forming layers by sequentially contacting the at least one region with a first solution and a second solution. The first solution comprises a first layering material in an ionic liquid and the second solution comprises a second layering material in a second ionic solution. The first and second layering materials can have a chemical affinity to each other. The first layering material and / or the second layering material can include polyelectrolytes, polymers, carbon nanotubes, or combinations thereof.

The present invention describes an intercalated clay intercalated with a polyether block polyamide copolymer. An article is included comprising a matrix polymer and an intercalated clay comprising clay intercalated with polyether block polyamide copolymer. The present invention also includes an article comprising polyether block polyamide copolymer and intercalated clay.

The present invention is drawn to a method for characterising nucleic acid molecules, which comprises the steps of: i) introducing a modified base which is a substrate for a DNA glycosylase into a DNA molecule; ii) excising the modified base with the DNA glycosylase to generate an abasic site; iii) cleaving the DNA at the abasic site to generate and release an extendible upstream DNA fragment having a 3′ hydroxyl terminus; and iv) incubating the released extendible upstream DNA fragment in the presence of an enzyme allowing for extension thereof and an additional template nucleic acid and analysing resultant fragment(s).